<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JW15</accession>
    <name>A0AAE0JW15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7877 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_136256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000029">
        <property type="protein sequence ID" value="KAK3365389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JW15"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="2">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3365389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="125" mass="13257" checksum="832F26604095C3D2" modified="2024-05-29" version="1" fragment="single">MAELAVAAPQVNGVAELSRPDSPSSVNSSTKRKRDASDDGDLDLNGADPTTPKVNGAHPHRDKKALIRDFFDVLQSLDPTGPVILKRPLADALSDGEPSAKRARSEDKPLTVADKTAQGAYRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JWL4</accession>
    <name>A0AAE0JWL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_491022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000030">
        <property type="protein sequence ID" value="KAK3365377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JWL4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042131167" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="33"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3365377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="350" mass="36883" checksum="F5CF9BAC9F2D2D84" modified="2024-05-29" version="1">MVGHGLFQPARILVYGLSALLALHPTPARAAGTTVEFDLISPVAGGRYRVTHEKGLPVVYMLQNVDEAAKNAWHFEWYIEYIDPPPPGPFPSEIFALGGVGVGEWSHAGYGEIIQGGDPLVGLAHPPDFPRPNTGFVKDMPPGLYRFRWAYSIEWNHDLNGLGICFDDATTASGYTLSLSYRIKHGNFTFTVDNDAPVVVQASLDPTLATVKPVETWYSPDYTITCAWARNVTEAANPCRATVNAAQAAKISSIMSWKSSSVTSSGSEPAITSSGASVTSFRAPYVVTSGALGSATTTGPSLSSTALSTMPASTSGPGGNSAAGLQPGVRGVVPAMITLLWAVSVSGFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K031</accession>
    <name>A0AAE0K031_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_489406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K031"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="310" mass="33917" checksum="1866937DE2C35B00" modified="2024-05-29" version="1">MPGNESTTATSFIPRDELKVGNADLTLIATSPLAYFDEASSDPWLNISTSLTDEQGLQWYAKSGLSILGCVEQYQFCTDPRTCSKLDALYQLRATPNYGLPSLTARQKAVAGLVWKSVWAAQLQYGLLFIDKQILVANELIMSSLNSYVRSSKIPSNQWVTEAWNFANISLAVLQRRPGDYASPAAVLQQNASRIIQPDTAEARALCKQIKTRSSKHTSFKVLSLALLPGIAALVTLLNGVLPNLLSKTSRHGGGGGGKNATTAWAGYGFCQLLRLMSEARGIGPWDRQEKTVPTLRDRDFKFPLFDNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1I9</accession>
    <name>A0AAE0K1I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="261" mass="27592" checksum="7A30F97345D09865" modified="2024-05-29" version="1">MVPGSSPAPLKHLPMTTQGLMQRERDGSKRKRSSPTLLLPPRPPTCRQISALIFSLRQRPTSVWRAFAAAVFPSSDGAVSSARDAAVLSATAAALLPASADAAVTLPVVFFPASATASPARRAAARAKPSARILSSRAIADDSQSIAPAPLHPRRSQTNIEPSNDPSQPPDAAASRSEPFDPVRDAAPVRRSTLMPFDPTHGDDHGDRTRKREPSSRSNEDEDDQGAQTGAAGPSTSSTKPPKSNRKMKKTGTKRGARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K506</accession>
    <name>A0AAE0K506_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spray</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_310638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K506"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="96498" checksum="211299B9E0A72E8B" modified="2024-05-29" version="1">MDYYNSQRPSRPPLHSSVSTGSFSRISTVSDITDLDSFPEGTTNIPLLGRPSLVSLQSDDGGRSRSDSEENGYSSPPSSGWSPHTGYSPSGYATVPPPASTPSPRQHGRPYAPNAAPSRRHHDVIPEEEDGVDLVLMQSAAPVGFDGPPSFTAQESPEPAFDLSSTLGPMTWADEQFIKGLQKQEAQGKLTGGLGLGIKTDSILTEKALLATSPVVEKSPRLSRAFSFSRAGGPASSLSLADAVKQLGQSEANKRGKVIEVVMETDPQDQSEVDLSVVAGPDKELSNKLTMRQNTFPVKGGQTQVFYPQPDWKPFSMRWPYLMFMILLSIALAGGQEVLYQKSTRDPLVKFRTPSDIPAGEYFAFKFLPTMIAVSYGVLWQLCDFEVRRLEAFYQLSKEGGALAAESINVDYITDFSFLRPIRAFSRKHYAVTISSITSLLANALVPTLGAACILLSPDRDTRLRHPGSEKSILIHYVWSRFLSVTFLVIACLGCVLFYQLQVRRSGLLADVKGIAGLASMATVSHILMDFKDMDVATHKDIHHKIRDHRYALRNSSLTPDDLNPPSKQERERYKKNHLSENPQPLMLRTKGAIPFIIGILLFLALIPVFLFTPATALTDKVPWVVTLLAVCIKLSWGALETDVRMMEPYYILSRRYAPPKTLTLDYTAMPIGWVAIQGMLNGHWLVFFVGFGTIMTEILTVLVTSLATVEGRVFIALTNKAPPPRNGDPPSSHADDVADINAGQETVFSFWISLALAIFVLMYMGIVALIVFVRRRRVFLPRQPNTIASVLAYIHQSKMLYDFVNTAKLSNKEMVDKLEALGKTYGLGWFQGRDGSSHCGVDEEELLSDYKFGYDYSRATNPWDENEVQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5F7</accession>
    <name>A0AAE0K5F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_403224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="58"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3369967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="47734" checksum="080596BAEFD34A21" modified="2024-05-29" version="1">MNGGNSNSNNNNNNNNTTTTEKNPNINTEVQSIPPPQPPSTPSAIGSIPGPPPNGGTLAWLQVLGAFFLNFNTWGLLNTFGIFQSEYSHGLLRESSASAISWIGSVQAFLMLVVCVLCGRLLDAGYFYVDITVGVLLAVLGMMMTSLATQYWHVLLSQGVVVGIGAGMCFIPSIQIVGTYFSTRRSTAMGIAATGSSIGGIIYPVTLKQLLITTSVGLPWAIRIMAFIMLATLAIPLAVMRPRLPPRKSGPLINAAALKDPAFAMWLLAVFFTFVGLYIPFFYVEKYALDIGVAPDLAFYMLIIMNAASVPGRIFPSIVADKVGNMAIMVPAVLLSGVITLAWIKADTQSGLIAVAFFLGLASGSIQAVLPANVAFLCPDLSMLGTNLGMTMFTSGLGLLIGSPVAGAIIDHQSSAGGVVYWGALTFAGGFVIVGSLLLVVVRTIKVGFALVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5H8</accession>
    <name>A0AAE0K5H8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_485894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5H8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3369992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="515" mass="55925" checksum="D79E1FE229AE980E" modified="2024-05-29" version="1">MANHNEGVNPLRPYYIPPTIGEPLDSLPTPGPNAFAQGNATGMYASKARDIFSDIDYKDYLSEPSPSVVQTIKDLVDELIWKYTSALMAQPFEVAKTILQVRIQDNLGGLAAAAATAAAAAEEKRQRPPAQQNISMYDETEASDSDSDADEMTYFSSAHRHHHPQPSTPTPSRQNASISRQPSATQSPRAPPKPIPAYQLAIRTPNSVLEVISQLWQKEGAWGVWKGSNATFVYHVLQSLVENWSRSLLSALFNVPDLGVKNDLDRLVDIASPYPWASLFVAAAASVVTGLILSPLDLVRTRLVITSTANGTRRTLSALRNLPSYFCPSGLVLPTILHSLVHPILMLSTPLVLRGYFMIEKENSPTTFSIAKFCTSTVALFIKLPLETVLRRGQVAVLSSPQYVQAFEAPTSAESGKGRRVGGDRLETIVPVGGYHGIFGTMYAIANEEGSRAVPAAVSRTRTPPSRRGKTTVAETVYRQGQGLDGLWRGWKVGWWGLVGLWTANVLGGGGDGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5U8</accession>
    <name>A0AAE0K5U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062442" evidence="1">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="11725" checksum="C1A5049482E7AEE0" modified="2024-05-29" version="1">MTPPFDNARSPTTIAPGLLHLVGSLSLVLQLQASLPTERRDLPPGKSHPLRLKSCSDVERVHGTMNVGIACWKLPLRRLTLKRVIIPMLHSLGISAKPSPPTGVILSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K607</accession>
    <name>A0AAE0K607_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mu homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_528417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K607"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3370701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="448" mass="50655" checksum="60CDF687718FC6DC" modified="2024-05-29" version="1">MASAVFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEESSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKALEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRTTRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIIVPVPDDADTPRFRTNVGSVHYAPEQSAIVWKIKQFGGSKEFLMRAELGLPSVRGDDEHGGGMTGGFGGSMGGVGAPGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6R2</accession>
    <name>A0AAE0K6R2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_318896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="146"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3370642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="36475" checksum="E810D1F6CDBA4426" modified="2024-05-29" version="1">MGRSERHTDSESHSGASVNGTSEKKHKSKNGRNKKRNHDDDNNDTFNTASHSLAVKPPNGNAERRSSVSKPARDFRDMPSPSPKKKKRKTSTAAIVAPIPEAAESPITRSPSPVIDFDGLSRPSLGTRERLEETDAQKEERMAKMKGAVRTLLECVGEDPDREGLLATPERYAKAMLFFTKGYQENVRDIVNGAIFQEGHNEMVIVKDIEVFSMCEHHLVPFTGKMHIGYIPSNAVIGISKLPRIAEMFARRMQIQERLTREVANAIMEILKPQGVAVVMESSHLCMVMRGVQKTSSSTITSCVLGCFERKEKTRNEFLSLIGVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8I5</accession>
    <name>A0AAE0K8I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_288176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8I5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF425">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="166"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" evidence="1 2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1 2">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="1 2">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="798" mass="88905" checksum="0D25B046BFFFF14F" modified="2024-05-29" version="1">MPAPQDLVGDFWQSFVTKKPGKVTAIFPSSLYETLLPHPQDADSGTSKRNFGQGYEAAAAECRTKVARIVRDCKRTNTKWTDPNFDIRGSQRDCLVGLLWQRPSPRANPWSVDDALSTLQENQVLGEAPLVLDIPTLRKILTRKPIYDEDSNNDETFDPDPGSVHRVNWIYEDPQFTINGMTDSDIMQGSNSEDCWWLSAVATICHREDLMDKICVARDEECGVYGFVFYRDGCWVSTIVDDNLLLKNPDFSAVGGNICDPSNSAMRTYRKAKQTGSEALYFASCRDPNETWLPLLEKAYAKAHGDYNAIWGGWIGEGVEDLTGGIYTEMVLEDVLYKESLWKELLNEEKCFVFGLDILDAGATDGKNGLANCHAYSLLEAREETGEDGKRVRLVKVRNPWGSRGQDGVGEWNGPWSDGSKEWSPYWLTKLNYRFENDGVFWMTYSDLLGTFTNLYRTRLFDESWTVTQEWTSVNVAWLTGYLQRKFIVEIKKAGTVVIVLQQLDTRYFRGLEGEYNFLLHFILQKQNSDPGDYICRVRPKAENFWQANRSVSCEADLEPGIYEVLPKITAMKDGDRPAVEKILQQAADVKPQKLRQVGLSFDLAHSKALRAPAVPAAAKEEEETPAKEEEEKATSPEDSGEKAEEEQEEEEEDAEESETEDEDEDEEEDGEEEGEKGNEEVAPEGEKEDGEDEGGKQEGDNAEAKPASEKASRAPSVNTGLEPPPPDGSRPPSQLGPEDAGDRGGNGGGEGGGDGDHPAPWNAVCVIGLRVYSQDDEVAIQLADPKDPQEASSLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9L4</accession>
    <name>A0AAE0K9L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_513466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="242" mass="27034" checksum="6A52C9CB6F88F8BB" modified="2024-05-29" version="1">MRTLDHCFPMGQPKDGAKPVRRDREYLAGTRPRWSPPEPGTSRKLASGNGRSQAQRAFYFELRDILLREKGRIPSTGIGWFTTGHITSGRLSRKQESLSPRKSGLVWDFCKQAWGLVSVTCVSYLSNSCFLEPAAWEDFGPGIWQALQRTTARASNPKARHSLLEGVYLYGTCDSDFAGDCHGAKSTSGWIFFMAGGAEVIENRIKLEDIPTHENAADDLTKPLDKTQFGRFIELTKMVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAF8</accession>
    <name>A0AAE0KAF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_298828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAF8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3372497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="517" mass="55617" checksum="63F3AEC17BC60C85" modified="2024-05-29" version="1">MGLKFSDLWAAPEVNPVNRKARAIPFFNPINVYGRVFFFAWFGFMIAFWAWYTFPPLLTVTIKADLHLSSAEVANSNIVSLCATLLVRLVAGPLCDQFGPRKVFGGLLLVGSIPLGLAPLVQSATGLYASRFFIGILGGSFVPCQVWSTGFFDKNVVGTANALTGGFGNAGGGITYFIMPAVYDAFIRGGHTPGQSWRMTFIIPLIMVVITGVALLLFCPDTPTGKWSERHLQAQKSLQSHGIKDVVVDVPGGITDKASSSTPSDTDNKPVDGVIEDKKPVVFDHEAQLSKAEMVETARGEIIQKPTFNEAMHVVFSPQTGFHVFTYMCSFGGELAINAILASYYAKNFKRLGQTDAANWAAMFGFLNFITRPLGGIVSDLLYKFCGRNLWLKKGWIIVCGIVTGVLLIIIGQLDPHGDAEGTMFGLVALMAIFLEAGNGANFSLVPHVHPFANGILSGLAGAGGNLGGVVFAVIFRFMDGGTNYAKAFWVIGIIHVAVNLAVCWIPPLPKNQIGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAP2</accession>
    <name>A0AAE0KAP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_295013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAP2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000037">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="500"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="558"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="808"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3372421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="99905" checksum="4158CBD3A792F1D5" modified="2024-05-29" version="1">MATESTMTELGSLSANTSFSATTPTLTNSSCTPDADADADASSNAASLSLSSTPPTTASPDSMSLSLDPVDIRLPKQECLIAPLLDAAIPLLKSAQLAIEEQQRDTILDSLDSRDDQEELFSGQQTPMGSAIVVELLPPAPTPTPTPSPSPTSAPPPTSTGRARRAPASMPVYNIAKLSGTDAHGKRRAKGDIVGVQKRRRTLHHSAFDIAPKSNNNTSSTDALPMDDQSMEDGIVAASPYDGPPPSPNAKTARPVKKYKTKAAAAAAAAMVPRATRLSGAPAESLATKLSALGKRARDQFEKGIKKMPRELRRLKDTDEFAHIDTRPIRHTVWSKGKYVDPDELEEAADAPPRKKAKREESVAAKSDHDHEEEKSIEAEPVAPASKRPHVKIWAEKGLYAGQEMPLDMIKAMKLTAPERKKLASHPELIPSDQPNRVLPMPWFGGLRALINGRGFKLPFDICNPLLPGQPKPPAYRTMTKNRFVGDAAAYWKKTPHVGDFASKCVCKPEDGCAEDCQNRIMLYECDEANCNVGKAYCQNRAFQNLSARTKQGGRYRVGVEVLKTSDRGYGVRSNRFFEPNEIIMEYTGEIITDEECERRMNEEYKDNECYYLMSFDQNMIIDATTGSIARFVNHSCSPNCRMIKWIVSGQPRMALFAGDRPIQTGDELTYDYNFDPFSAKNVQKCLCGSPNCRGVLGPKPKEAKPPKAPKEVKSVRGSVKAGKRKLKELLAGGDGSDGKATKKLKVVKKTKASFSAKGLKAAKGAATAIKRSASSISVSATTAIGAAKKTKRAYVRRSTTNVLTKTKTYSKKGSPKVSVSSRSSSLTTIVAAGSATDKSAKAKPAVTKRTPKKSAKNSTSKETPASSAVKASVSSSARKRTPSWKALHADDGDDDYSPVPWKKSRKGLELPRASKIRLVQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAW7</accession>
    <name>A0AAE0KAW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_302952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAW7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20892" checksum="E632906760C89D92" modified="2024-05-29" version="1">MVLKPSHSADDPIQCKLIPMDLDTPAKYTTLSCEEGTADPPAKITCEGKSLQATPNRELALKRMRHSRNVQLFWVDAICIDQTSIPERNHQVSMMGDIYRRAARVNLWLGPGDDLSAKEFSDFRRLQVLAWVISHCIPSWLSSSDLPNEMTIRPGSGGGLQKLIIDSFFLGVATKSHWTRAWTIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEV7</accession>
    <name>A0AAE0KEV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_399881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEV7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="390" mass="43372" checksum="7CE148780A65EE22" modified="2024-05-29" version="1">MTLETTPTTATGSDIPNLSEFLAAGGDSSYRFNFIGEGAANLVFEILPIDGSNASEDIKKMYNDKKKPGNLLRVPKSGTQAFNCQVLHAYWKTAVEPLFEPGDLAQLHLIRLGSSSQRVVSLLTAALEENETSRRGDFQGSKVSSASEYGMLIENMSMKQPSDLVLEFKPKWLAQSPNAPPSSTRCRNCAREAYRRNHHHPSNKKKQKSSIPIPLCQLDFLACSASRGDPAALNRVLERVSVIKHQQRPTVTTPTSAAAQQQQQYASLVNWLRTNTLLSRLRDMQVANDPHGSLAVTSAEDDDDASKLQLAMTLRDCSCYVRISAPTENCEIEIEAKLADLDKKNRDAKLGYWQATERELIEGGYYEGMEEPRQETHCQLGRLPKHTKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF64</accession>
    <name>A0AAE0KF64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_480894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF64"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3374795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="343" mass="37238" checksum="6CE897F2FE842797" modified="2024-05-29" version="1">MGALFSKNQFPVDGRVVLITGGSRGTGLEAGRQLAANGADVVVVARDAERLQQAVFYIQEGAIRPETQRFHFISADLTDPSEAQRIMGEVVAWNLGSPPDIVWCCAGATHPTLFIDTPVDQFRAIMDANYFTAVYMAQAALQAWLRPPLTPSSSKTGGTTAVQIAPPPLPRHLIFTASFLSFYSITGYSPYSPSKAALRSLSDSLSQEMNLYAGAYPDQPRVRIHTVFPATIYTESYAAEDLIKTDVTKKLEEADEGQTAEEVARLSIRGLEAGQELIATDLLTRLVMTTVMGGSVRGGIWRGLGTWIVGCFISVVMLYVRATHDSVARKWGKENGASGMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJC4</accession>
    <name>A0AAE0KJC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_477893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJC4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3377754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="18257" checksum="623B9D3F0CA0E7EE" modified="2024-05-29" version="1">MSASLLRAARGPSSSFFRANTIIARPQPLAARVGLVAPSLLAATNSNFSTTTRVRSEHQEETFEEFSARYEKEFNGVQDVFELQRNLNNAFAYDLVPSPSVLAAALKAARRVNDFPTAVRIFEGIKAKVENKGQYQQYLDELKPLREEFGVVLKEDLYPEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKA0</accession>
    <name>A0AAE0KKA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_436760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000010">
        <property type="entry name" value="Fungal transcriptional regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3378234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="871" mass="96033" checksum="1CACDAE55703870D" modified="2024-05-29" version="1">MTAPINTPVNPAKDAASARKRRRRAPAGGAADDCFTCAKRNVKCDRRRPYCSQCLEIGNECSGYKTQLTWGVGVASRGKLRGLSLPIAKAPPVNNGKVPVKSPIVRTRTSSTASTNQWMPDQDGRLPRDDMDMSGIRNPSLPATPYHPYGMSQMSPTEQQPPTGWTHISFSPVMSNDGSRYSGRGHQMGVSSPGEMMATSMDSMSDVDYMSPMSHSFPRDDLPPFLHSPSIIYEGFPSHSSPMPQSPVSAIMIEQPRAPPTSCPSLVYAPSEPASSLQSHMSHVDSLEAQLSRKMAQDCDVLVPETPDMETYSTSVQSHGGFWAPSNADEESANQQNIAEQNSVRWSSFPSQPPSPVLQVSSDLISKMPFFMDYYEKTMCPGMVFIDGPGNPFREHILQLATSSRSLQHAICALATCNLRMKRRLSLGQHGRDIGEKRIDTSLIDSGSDTQPEDQSLSEEYQHRNLAVRLLNEQLNDAEKSTHDSVLATILLLCHYRMAESGIAKFHTQFAGVKKILGMRRMSPFPASRDSTWMEALFTYFDAISASINDRETQLNTSFYGVLPDAQLLPPGAENFVGCDRELFKTIIKLGRLNLLSQHRPVQNLLSNNPHERNGTSSRSGSPLHATFNPSPHLSTEHHSIFGGPHHNSNNMRFDGNGFGSTLDDDVLLSPGALHSPSGYDDHRSTFWREWKDARIALQSWEFDASRVVSSLPPASSGSPPTGAQVRDLSSLSEAFRYAALLYTERLGSPNVPSAHTNFRNLVSQVVYYATSLEAGSSAEKFLLWPLFVAGSECVNELQQNIVRSKCREIMARSGYMNNLAALDVLERIWAGDWKEEASSGSKMRSVTQQGPFNWTNCIGGPGVEVEWIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKI2</accession>
    <name>A0AAE0KKI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_244534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20180" checksum="1116E851DB7389AC" modified="2024-05-29" version="1">MLKLATFASSWLTVFRPFICCGAPLGMRRWITLTAGHVGARIVCLSTAVITSNGVQVAVQAKPPAKLNLTSKVSIAEICSLSPECAERILLLQSRRLLSIQPLPPRTMSLRYIISSGFYISSITQVAFLANLCTSQDEQEGCPLTHTPRYRLGGWAGSVPSLSDPAGRVTTSLQHKLTRSRGRSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKI9</accession>
    <name>A0AAE0KKI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal L37ae protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_548516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKI9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090555" evidence="4">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="138" mass="15052" checksum="50692935ECF391E8" modified="2024-05-29" version="1">MAKRTISMSLFFFVFLPLQKRNLLTSQQKSVSPANTAYGASLRKQIKRLEITQSARYVCAFCGKKSVKRVATGIWECRRCKKTLAGGAYLLTCGSKPLDPSPAERDCGSLSFGTGLSFSSADGYFGVITYTPVALLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKU5</accession>
    <name>A0AAE0KKU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_478403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKU5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="248"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3377941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="44419" checksum="64AFAC23927F351B" modified="2024-05-29" version="1">MPLTLKRIFVGGRNLKRAFIGKRTFIRTSAATAMPSSTTIYVLGIGNLGKFVAHSLKRAHAETPVTLLFHRASLMSEWESAGRGIECVSLEGAEDVPDWATGFDVELLQPLSPSSSLSKEPIANLIVASKTYMTSAALGLIKHRLGNTSTVLFLQNGMGTTDEVSSSVFSDPDSRPSYWAGICSCGVYSTSPFSIVHAGRGPILLGPVVSKNEGVIGNNDSIKSNDAVIQQLLTTPTLEAAATTAMGIKKAQLQKLIVNAMINPLTAIFRCKNGELFSDPPRLALMRLLLREAGPIVRAILREHSTTTTTTTTTTTTTTPPPPSQDPADDESFTDEGLAASVLRVADNTARNTSSMLQDVLAGRKTEIDYINGYLVSEGQKLGLPHKNNATVVELVEGKVVIRVEDIQERFHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1R9</accession>
    <name>A0AAE0N1R9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_405142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1R9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="33218" checksum="0A8AB23326732D9A" modified="2024-05-29" version="1">MRLCRHEGRVAELENLLIMAIYGSNYIESAGNNYDITAQLCKAVFRDESPDPEITLTVQNLSEYYPQVRYLRRENRPSDHESVVKSRREIIQHAKAFAAVIRFIMDGNEWTEDAILQTHEILHDGLDDDVLAGTYRHYEVAVKYEEPGQRREKASICLRARAVPAYMRDMVGRLNKMGAEMASDMPPFDRVGFAVRFHHQFVNIHPFGDGNGRMARIITNALLLTYAGRILPIGMTSYERRAYLMLCAEASRIFREEDMEVDFAEQTGHLHLAEAVGIWSRQAPLPAGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N297</accession>
    <name>A0AAE0N297_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_535473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N297"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3367513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="427" mass="48308" checksum="837DFAC969C12518" modified="2024-05-29" version="1">MDSDGPLLELSQYQSVAFLFLANVVIFAAIYAPNNLRPGLLIPTWSFFGISFMTLHRLPLGRELLSNLGIYLTIASLLWPIGLFTAEPLMIQVVTTTSVVDDKSPPPMRYRYYFWKWNWNLRQAYRIYNNPRKLPDRFPPSSPPTTRALFWFAARRLAQTAGLLLLHTAVTLFCATIGGLGDVQADDFSPAHEPLLSSFFHCWQQGSRRHLRIRASVLLYWVTHLVIPLQAVHFLLSIVFVSLLRVDAPDEWPPLFSSPLQAYSLKRYWGVFWHRLFSPGAVIWARFVARKGLGLPPGGVLEKALVPFIVFSVSGVAHAAVGWRLGYVGLDRDIKFFLWNFAGIFGEVALLRGVRAVLGGRKITSIRQGYGGILLTIVTRIVGYFWVVVFLLWAMPPYLYPKLYDSLLQKEVVEQRVPAIDAGGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2C2</accession>
    <name>A0AAE0N2C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_489599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2C2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="8">
        <location>
            <begin position="361"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3367665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="136395" checksum="42E573B6B6E02C5D" modified="2024-05-29" version="1">MTLWRGIHRGQTAPPLIRSSTNEPFGLDVIFNGDNPIADIVAVHGLNGHREGTWTAEASQANWLRDLLPADIPNARILSYGYNSRTHNAENLSLQSIYEHAITLVQDLCTYRRNTKTENRPIIFLAHSLGGILVKNALIHSKLSKSSHHSIKRCTSGVAFFGTPHVGTSAANFASIVLSIGSIFTRTNSTVVRQLRENSESLHTQLQQFNPISCDFQIVVFYETYKTNIKFGKRIVIVPLHSASLPGNQGGLCIPLRKSHTELVRFSCPADPDYLVVSDQLKILVSDASRVLETNSVMSTATSLTAMSGSLTSLTVDCKQPVMKLPFSLPLQPNYFVGRTAELNTLHDSLFGTPKTKGSSEEQSRVVVVHGLGGAGKTQLSVAYAQSHRHDVDAVLWLDGSSENNTLLSFRSIAQRFLDAARQANGGEESINPLSSRLPIGEYLSATGQISTDEKTLPKISKIVMDFLRSENESFTWLMIMDNVDDLPRYPVASFLPQSARGKIIITTRRTEAIQFGQPLEIGQIEEESGIQILLNASSLRTKAPTDPENAKTIAISLGLLPLALEQAGAYISRTQMQLGKYPHLLERHRRELLSSPNTLGYNQVSVFATWELSFKQLVEEDNVAGNLLTLLAFFHHSSFWEGLLLAPFESNESSETSEPTVGSPEGYKWLHELSSSEFKLTNTLGKIFSVSLAKRNAPSGNIHLHPLVHAWGRERLTPVSRKGKLVEAVVAIGSALEWAYRPNRTSSKEVREFVSRVVPNADHCIGLVTQEGSKEMFSTILSDRQSAKALFYIGVLFENVSKLRQAEDIFAAIVAAYENDPSILSPLMAVNAQRRLAHVVNLFSRYKEGETLLLQAIPTLISLVGKAHPDTLAAQLELGNVHHRCFRYAEAEGLLREVIENDTDASTGGKMGRMGREATSILGLVYKHKGLHQEALALLKRVLDQASEENQDGAAHLLTLKYRHTLILQELGHWNLAMQAYEEAFDGFKATLGFNHPLTLRTANALGRIYCFLGKYAESRDILDLVWKGQSALGFSKENETAQLRTLFNIGVLNREEGRPNEAFEMLDRALRAEQALYGARAHSTLRCQVELGILQTVRGDLEEAARNLEEALSNQLAHYPDSPMEHAHTRTALAEAFTQLKSPSQADETLEPALRFVRATLEPDNPVRLKVELAHATSLLAGGRGGEAFAETKKLVPLLESTFGLKHPISVRGRVLFKDSREKINDIEGDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2R1</accession>
    <name>A0AAE0N2R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_535251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="488" mass="55353" checksum="B6B7C91D3DFBA092" modified="2024-05-29" version="1">MAGIYFEKLYKYREGGFCPIHIGDRIADRFTILHKLGKRHGMRYVALKVVAADWSEEYEKSGAVEILRKFESDNGSPGIFLVELKHFFHTSKNGQHLCQPRFVVEFAQQATKALEIMHSLGVCHGDFTLKNIAIELDASIDSLSEAELEDILGDPWKHPLEESEDEIALSRPKYGVQPVDLSLLPPRFLSTKLCVLDFDQSFLVDNPPKDLARISPPYLAPEATFSLRNGPPGDVWALGVPFQDGYPVHWPFEPGVEYDNFENINVRLARPLELRVREFSCYEEKFSLAIPEDGPARPRVKFYAENATMIKDKDAELFTGLLRKIFVFDPERRLAASQVLCHPWFHEIDWSSYESSSTYDLQRFPLHIKTTQEDNDDETTATREAECAQENHTQDHHPEQVANIEGDKQSEETDGKILPRSADDKTGNDEDAESERQNEETGEEILTNSVDEKTLGNDKDAAVGQEEQTRNLNAAREMHATTKAGKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3H2</accession>
    <name>A0AAE0N3H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3368039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="615" mass="68181" checksum="856AB764ABFD6FA3" modified="2024-05-29" version="1">MPRVEWMRHVRKAGGHYRALSYAWGDPDITAPITVNDCLHHVTLNLQSALRHLRHDSVSVVLWVDAVCINQSHSGEKGIQVRQMGRIYRDARDVVVWLGEEADDSNLLLERIAESVEVDDPDSLPPFKGDDEDEPVRLARAFLAFSRRAWWTRLWVIQELILAKEVSFHCGHRAVSETKLRVNNLTQSTFSHLANQGIGSAPELVDASLMKSLGDMFRLVALRGQAMGAPAKDTAKSTLDQLVVKFSESHVSRPEDKIYALFGLATDADAYGVPDYSKDAATVYVDFARTIITGSGGLRLLLVAGLGSNALAIPSWVPDWTSRRYHSWVCCALLNLQATAGLGLKADFAISPDSRTLRIRGVICDTVCTIAPAPVAGQGSWLHPDAYFSAAGHPLLYSTDTNRPVTRLEALFRTILNDQSLDREPLDKEPKALHRAGATFLYGLGDGIIDEETPEHTPATEPAKAAGEQQCPDYISRFLRWTRQARNGRSNKQILELFLGELDSQSDLHKPWLESENDIGGSNYLEYQGGRSLVNNDSGGHLLETGGGLFGMASDLVQKGDVICVLFGCEMPFVMRRSGSKWTMVQSCFVFDLMRGEANDMIRKGKYQEQEFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4L3</accession>
    <name>A0AAE0N4L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dimethylallyl tryptophan synthase GliD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_551993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4L3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3370050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="472" mass="51957" checksum="8EEE61BBD3096BA0" modified="2024-05-29" version="1">MATTNGHGTNGVTTKKATASSPGTTTAWRTLTQYLPSRDPDTDFWWKYSGLHLAILLEEAHYLPEKQVEALVFFYHWGAPYMGPAPRADGKALKWKSLVQPDGTPIEYSWKWPQAESGSIEVRYDFEPIGPHAGSQLDPLCQLAAKELMNLLASSIPDSKVDNTWFHHFMSTLFEHDNTKLAAAAARGEPMSSTVLMAAEFLPKGVAFKTYIQPRLLGYPGVTPIDVYEKSIAAIEASTPARASVHEFLSTSAEGKAMAPFSVGVDNRAGSRLKWYFNSPHTSFASVREILTLNGKVQTPHIEGQLRALDELIKAVLGLPDDFPEDQHPAEFLVAKSPYNFPAPPPSADVDAPTPSPVLPGYPYYFDVAPGQPLAGVKWSLPVRNYNRDDLAVAKAFTGWMEKQGRGGDHAKRYLSMLERLAALKGVRLEDSKGLQEFISIMLKPNGEIDVTTYFSAQAFNEVADRQVGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5I2</accession>
    <name>A0AAE0N5I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51459" checksum="E57AAD8C027DA64F" modified="2024-05-29" version="1">MATAPGSSPYLVRIVPEDSGLWKVPQTEVAAKLASDLLQEDLEKHHVYFNQNGFHNHIPHHILALYGTGAGPDILQKGYDDNANYQRPALKPHDRIVDDLMKTWSHAQKYLGKDQYYPDFLRFFQKEMDARSGGWSDVVAEYLLNDDDMLARLFAGFLHPLIQLMYGMEWKQPAIVAEALAQTAVHGNDLKGFLLESERLAAAAAEEDQKSEKMPAIVELLEAIGKDENLAKAARMEDGNKIRDGVLVRAREDMIRVASRVRVRPDELDERTAEMFDACVYMAAAAAVHPSKVPKFDFFLMHHVNSSPIFLTINAQPWISAETKARLLEWKIRMDLIQYTARGVPALSLDKIASYKPKKEEKTPSATISDIITRRLHPLSDDGHAIKLGRAALICHDLLSRKYGDRDWVKIRGDDPWNKVAHLIVDSVEAPGETWVRSCGFEEAWKDMPDAQDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6X8</accession>
    <name>A0AAE0N6X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_401128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58230" checksum="F946DDADC270B157" modified="2024-05-29" version="1">MNKLHPHGEEDDAARNQAQPAVHEYPPDEHTRLLPNRLDSTPYLSPDDPAVSPYNLWSVRLVRYATVLFTLLTFIWWILVFISAFITPPGLHSRGSPFFAFSYTTITLITLLATLIFFAVPSKSSRVISIVTAGLLLVDTIIILAVTKTRHEELWVGVASVIWATLMAAWAVTADRVVQWGKTEEEERLTGRPETRRTLLEWTEVLLSSIVLTLMAVAVLLMTCTLTMRAVDSRLAPPGQRYWVDEDKYQIHLYCYGNATDSKGEKTTTVLFEGGEDTVENGLWQLAENAVKNGSISRYCFADRPGMAWSDVAPSPLSVSMASDALGETLSRAGETGPWILASAGIGSLYSRVFSSRHNQDVRGIIMIDSMHEDLLGRVGSPGRGFLLWLQGIMSPIGIDRILGALIRGRNAEDRTWGRASYQSGGTIFAKLQESLVADSFTKKEVIASRQIQDPNTPVVVISSGDKIRRDSEWEDKQRDLTHLTNNLEDWDIVDEAPHQIWRTLKGRELIEKRLKKLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N944</accession>
    <name>A0AAE0N944_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_254484</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N944"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="80"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="424"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3374638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="640" mass="67872" checksum="304979DF6B36D4A7" modified="2024-05-29" version="1">MAPHADETPAEQSASNGSLNNSQVERNVPQDGDYIQFERVSGAPLNRWSTVLTRGHDFPGAQAMLYGAGVPNEDMMKNAPHVGIATVWWEGNPCNTHLLDFGRIVKKAVEKENMLAWQYNTIGVSDGITMGGEGMRFSLQTREIIADSIETVTCAQHHDANISIPGCDKNMPGVIMAAARHNRPFLMIYGGTIRKGHSKLLDEDINISTCYEAAGAYTYGKLHTKCTSGPGANATPSDIMTDIEAHACPSVGACGGMYTANTMATAIEAMGLSLPGSSSYPATSPEKARECERAAEAIRICMEKDIRPRDLLSRAAFENALVLTMVLGGSTNGILHFLAMANSADVPLTLDDVSRTSNRTPLLANLAPSGKFYMEDLYSVGGTPAVLKMLIAAGLLDGSIMTVTGKTLAENCAPWPSLDPNQTIIRPLSDPIKISGHLRVLHGNLSPGGAVAKITGKEGLSFTGRVRVFNKERELNDALARGVIRPDEGNLVLIVRYEGPKGGPGMPEQLRASAAIMGAGLNNVALVTDGRYSGASHGFIVGHVVPEAAVGGPIALVCDGDVVTIDAVSNRIDIVALVGSSSAETGGVDPVDVIDKELERRRSEWKPPKMKPVRGVLAKYARLVGDASHGAVTDQGESAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N978</accession>
    <name>A0AAE0N978_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_260251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N978"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="90" mass="10761" checksum="9AA9048BDCA848A7" modified="2024-05-29" version="1">MIWRCHPTFYVWGFLPGMRCGGQPLEWWEKMKTEGESERRVLIPRNCSLVRYAFCIKGSRSRTLLEDRGEKRHQLSNHSSFVFKPYFPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9S5</accession>
    <name>A0AAE0N9S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_276837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="341"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="845" mass="91670" checksum="67C75E337D3409E6" modified="2024-05-29" version="1">MNMPSATVRRLYEDQIPSFMSVFDLDTEILVQPSLVSGVDPKLVMEMEDTKISRDEQPQLRPCALPSDSAHKHNDSTSTQTTESEDSSPTTTVSCTDSSDLSDPSPSSSPDSPVNLAPLSSFAPALFAPPTFAPSSFAPPSFAGLSSMASLSVSNPSLERPMTSPAPRRPKNMKGLSIQPPFGSLTSSLVSEPSSPVFIKPAIPAMKRKPSQLSLKTNTSDLVTRGTLEIPSSPSVPPILQRRALKHSTSSPHMLSALKSATFGPAGGMTIPTVLERNESGLSSFLRPPKPLGLPTTMDTTITEEESPIKPQIANRVAYEVEPFHEVENNEDQKTPGYPDGPIRIYDDNVYLYLEPTAEEAARFDVVINVAREVTNPFKSLAISEEPPPEFKEKPADDSPIPDTAATNASFATAFEFFPEEPTADTPTTPRAQPLKEPEYIHMPWDHNTDIGEDLLGLCETIENRTKDGKSVLIHCQQGASRSASLIIAYGIYQNPDLSVNDAYYAAQAKSRWISPNMRLMYCLQDFQKELAKRKVLSAGFKPRSGRSPTKHRMTLSADNIEAPPKEPLTAPLPGEDTASKTDTPERSPTRPRGNSTPNRREPISPGPSSAPSSFSWTEKEDETDPGKFGRFNIDSMLKPSQPDSGFASACSLSKPPPSPGFAPLSFSRPPPSPGFAPISISRPPPSPGLPPLTLSRPPMSPGFGRMPSFSKPPPSPGFGAHRFGGSGGFLPLSLSATPSYSDNNEAPSERHITLLRGFDDDDALMSPRAETMTKNPLHEPFAGFAGMQFVEVPPTPNEGLFSPRETMFPRDPFFPFTRPLEIKDPRSPPTKGETPIVRSIDEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCD7</accession>
    <name>A0AAE0NCD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_479418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCD7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="149"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3378270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="223" mass="26512" checksum="120432DB5A3A8C23" modified="2024-05-29" version="1">MVQQNFWNSFINDGDISQHTYNPNHTRYLFAPRSRAENSKMVRKLKFHESKLLRKHDFVNYKQDNNHRDHDVARRYMIQKPEDYHKYNKICGSLRQFAHRLSLLPPENEVRRKHEELLLDKLYDMGILSTKSKLSQVEKNVTVSALARRRLPVVMTRLRMAETVQAATKLIEQGHVRVGVEEIRDPAFLVTRSMEDFVTWTVGSKIKQNIMKYRDKLDDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGS9</accession>
    <name>A0AAE0NGS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_197150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="239" mass="26223" checksum="F013572A217457C2" modified="2024-05-29" version="1">MLEHSCPKTPSWKEQRGHLASRFLCQCQSSTLFRSPFPCNNVIAEDGAGVAVRPPWILGRNGCHGLNGPMIPRQAGSIFDQHAPGACCQVQGPSPGLPVPTSLMELKRHATSEMFFNSRIRIHACLAVLYPHLNSDVVVAVDVVAVDAAKGSFSSLTISRGRPFHIRPSSTWGHFLIRKSSNITPWRSLGNKGEIAARGVGLRNNRTRRNPSLNELHPVASKPQRSRAETFLTDHTTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI87</accession>
    <name>A0AAE0NI87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_435556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI87"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Osh5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3382001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44989" checksum="9F5445D46D97B96F" modified="2024-05-29" version="1">MDSAQQQQANGGGGSWGSFLKSIASFNGDLASLTAPPFILSSTSLTEFSSYWAEHPSVFAAPAKEPDAAKRALLVLKWFLTTLKQQYASRSEQYGNEKKPLNPFLGELFLGKWEDEAGTTELISEQVSHHPPATAYTITNIPTGVRLEGYNAQKASFSKTINIKQLGHAVLIVPAPSSTEPDTYLITLPSLHIEGLIFGSPFIELDGASYITSSTGFTAKIDYSGKGWLSGKKNSFTASLFPTGKEKDVIFNVSGQWTKNFEIHSGAAKHNGKDSLVGSWDPAQQPTTKLIVAPIEAQHPLESRRAWAGVATGIAKGDMEAVGQEKAKIENAQREMRAKEKAEGRMWQRRYFGVQAGAPDPVLTRLGPAVGLAEHGDADKTGGLWRFDSAKADKVNAQPPLTEEEARSIAKELLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP12</accession>
    <name>A0AAE0NP12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_178195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP12"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="80" mass="8542" checksum="1175D8ABEC053AB4" modified="2024-05-29" version="1">MEGDATLTNPFTVALAVSYFSLLPRFALAISSLPSNNLELAQSTNSHRNRASLGYRLRAIGVLFLGGGLGGVRNTNSFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP78</accession>
    <name>A0AAE0NP78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_178569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP78"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="39522" checksum="7160E6A111917A06" modified="2024-05-29" version="1">MPAPKRQTHASGAPTSHNSITVASGRSSSNASSSAASSPVAADKVQVVDEGVGATTPAASSSSNNNNNNMAVSAANGNPFGPSAASSALSYENSNLDEITLRQLQEDIISYNHDMDFCKAQLEEPDLTPQEMRTLQLRTLDLGHQIRHCRHRIETLQIQLAKSGSRSTWQHYGATASSSNGVHGNARPRTLAMANGQAMVKRVADATPLVGKRSAEAEDEGSAKRVKTQSSPDHDTPVAFDGTANTSLQRLGLWRCRLCSAPKYLLAGNGRSPAAPCKWPLKDISKMITHFTEMHTEHTPVERCAELGAALSVNRGPFEYWLRRTRAQTGKTLQDGAKIDECIEDLINGEMPDLLRRLSRAAAGMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPK0</accession>
    <name>A0AAE0NPK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_449399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="36811" checksum="2A9EA9C4F776B6D9" modified="2024-05-29" version="1">MSAMWYEFPFLAKFSYAWHVYYGLGGTGRQVFSDIHNKYADGGPFVRIAPNYVITNDPEVLRRIASARTRYVRDEWYKAAQFHREFGNMASILENEPHEILKAKTASAYSGRENGADFEPAIDSQIAALVSLIQRKYLTSTAADGSSQPAELSLLMRFFTMDLISRLGYGESGARCQLLRNLMWERFGLMGLFGPSEADKADMGPILSCGFIRHGLTKQEVLEEATLQLVAGSETTATALLSTIMYLATSPLAYVRFKREIRHAIDSGLVAADSAITYEQAQKPPYLQAVIWEGFRMCLPVNYGHYKAVPPEGDTMHGIFRPERFLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQY1</accession>
    <name>A0AAE0NQY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_190866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQY1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="194" mass="21702" checksum="2DFFBFC4DB83A874" modified="2024-05-29" version="1">MLKVIRTVPGSIWACKLAIFALLRCRGTSKIYLHARKRRTGPQNREAAWTQPSTLPSAPPSRRTPRRMRFLGGCGGRGLRGDEASAHRSFVTLPIMQLPRQKRRGPGRGGCRRTSYRHESRPLTEVSWSRRSPEVAQSGFVEAVLTRVLLPRLPASVRMRPSPCFVSSTAHGKADSPDISTNQFLLGPDLPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS38</accession>
    <name>A0AAE0NS38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_467895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041927022" description="Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="300" mass="32354" checksum="7E86B50181C3F2C9" modified="2024-05-29" version="1">MDPLSISTACLTLLGAVGKTALAVTTFIRGCRDAGADLMSISGELTQLQQVLELLKDDTAVSDNRVLPESLQNQILSILENCTTVLECLNHVLHEHTGKTGAAKWVLFGKSKVAGLRMSLEAHRGSLNLVLALVSVSLSKAIKEDVTAIQTDVLDIQTGVLDIKQSTILLPQIMAELTRLRAIVSTGCAPSATSGQNFVLERYLDSLTLYAESVCSDVVVWDSDDDLPPPSRRFSTTSRAFSDNFKSVTEVFKLSMQLPSDKGRTMFFVALELMGSSTAVGLVQTYLSIMQMLDALKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS94</accession>
    <name>A0AAE0NS94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_430533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS94"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="411" mass="44152" checksum="4125988484CC1CBE" modified="2024-05-29" version="1">MLGALAQAGGGPGHGGGGPGHGGPPKPSATPTPPPLPSYNGTGPTMLRFGCHQLVVDRIDPLVNPGAIPSPHQHQIVGGDAFNASMPYSDISSLSGCTTCSYSDDFSNYWTSNLYFQARNGSYKRVKQLPSRVFFPGDNASVVTQGGLIAYYVSPGQNMVKAFQPGFRMFFGDPTLRSPPAGKWDLGNQTCFRCYTGPDFGGDEFAPCQDPRVDTMYLPNKKCYGIRSNILFPTCWDGVSLDSADHKSHVAYPLEGPHVFDAIGTAKYCPRSHPVKIPQVMLEIVWDTAEFNDPALWPEDGSQPFVLSTGDHTGYSQHADYVFGWKGDALQVGMEAGCLGAACPGMKTQSLEKGTECSVRELVGENYSGWLSTLPGNPKQPPVTTPTSSTKKPHPTKPPKGDYPSHGGHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD5</accession>
    <name>A0AAE0NSD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cofactor FMO1 FAD enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_430623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="599" mass="66185" checksum="737D17922235F750" modified="2024-05-29" version="1">MIDILIIGAGPSGLCAAKTFLQHNAAANIVLIDAHSTVGGVWAAEQLYPTLRTNNLFSSPDFTDFPMDPERFGIKPGQHITGEAMHAYLSAYADHFGVLKRIRFNTKAIKVYRRDDGSSGNHDNGGWDVEVQSSTGEGETSVLSCRKLVVATGVLSVPKMPKIKGMEDFGAPLLHSCDLGSRVNAVLEEPGVTRVAVLGGGKSAYDAVYLAATTGHKVEWIIRRSGHGPAWVFPTHTYLGPFRAWRERLVTRRVLSFMSPCVWPDYSGFGWLRDFLHVNSVGKFIAGKFWGAIHADTVRDCRYRTDQQFKVLEPELSPFWYGTVSGVLNYETDFLSLISSGQVRVHRADISHLSDNKIHLTSGNEDATEETALELDVDALIAATGYSAKPAINFSPSTSLSDLGVPTTSLDKTQAEFWADLDAKSDQLISQQFPQLLSPPSKAEPLNTNASVPETVTPWRLYRGIAPPGPTASGDRSLVFLGMFSNIANTIRLEMQCLWALAYLNNKIPNLENKDEDKDIYAETSLAQRWCQLRAPYGHGHAYPDLVFDQMPYWDLLLHDLGLATRRKPSAFRELFEAYTQADYCGVVDEWLAKNGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF2</accession>
    <name>A0AAE0NSF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_468471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="24955" checksum="EAE40171A1139E51" modified="2024-05-29" version="1">MEAVDPSAHAALQNPERQELLTVHKKPFQHIQPPDPSFTCTCLTCMLRWNCLCLVVDFAYWQKNLDTGEPISVIPRGTTPKWNRDLVARNASIVVKALRSPLWHARILEAHLASTIRSIRRHGLNKGNRRRRFRMADEDVHAETDVFLERSGPPTLDFPYHRDNYYMLEAFLPNRSWISERKKWVYLPAEQHDNDVEIAIRWEAWARHQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSN7</accession>
    <name>A0AAE0NSN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_141026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56300" checksum="02687BD8C2432900" modified="2024-05-29" version="1">MAELILAVIPLALKSIDRVSTFFGRLQNAPRRIQFFRSQISHLKENLQHLQDEVVYSPVSLNLNPEMVEQVSHFLERARRFFDGYKPTGSAVRAGALSAIWTLKHDEELEEYSKEIHHISHRVILVWLRLICSRQRGPPEQQMRIQNDTNALASEIENLSLTDLHRPGANNGSGDLVLAQVAAIHGVDPTLPITIEQKLKEIDNKIRKYMADLKIPVNDIMDNVTIADEAAFRNVDMTLKLERVPSYEILHLEQMQIISLDKDTVVLFSQRRDQSIRVKHLMSRHTTPFTPDITSRHTSFLSSHCITVIDRGTHHLYHVSEPRYSFQAPQKRKRFQSVLRERDLLAEFEASDITWGGKPVGPRAQVLQFWGPSKGSTEVTITVLVEGEEGVKHTEWFIGDFKDGVEVKVRKMSRFTKGRTKVVARLMPLYRQESPAGDEDVVIAFSGQAEAERFKHSFKKHYPLPIAGGKKPELRLDGWSFEDSPDILMELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSU4</accession>
    <name>A0AAE0NSU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_468971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSU4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="354"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="50320" checksum="E6688C38BDFB5E9E" modified="2024-05-29" version="1">MKIKALSRSTTAQQTPGSDVQRAPRNLAPEIHPFEKAREYQRALNSVKLERMFAKPFLGQLGTGHVQGVYSMCKDASSLSSVASGSGDGIVKVWDLTSREEKWRTSAHSNVVKGMTFTNDKKLLTCGTDGVKLWDPYNSANDSNPIASWQEGGPYTSLTCHRTGNVFASASGAGCISVWDLEHSTAPQKIQWPNHTDTITDVCFNQVETSIIGSTASDRSIILFDLRTNMPILKTVLKFASNRIVFNPMEAMNMAVASEDHNIYLFDARNFTKAQNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRIWKRDQGQSRDIYHTKRMQRVFRTLWTMDSKYLLTGSDDGNIRLWRANASERSGVKSSKQRIALEYNQALTQRYAHMPEIRRIARHRHLPKVIKKAGEIKREELGAIKRREENERKHSDRKFQARKSEREKAILAKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSW2</accession>
    <name>A0AAE0NSW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_541202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="164" mass="18031" checksum="3C735E962C961F32" modified="2024-05-29" version="1">MERASKRQRLPASAPLRKAADSITAYNDLKLNKKYKYIIYKLDDANKNIVVDSTSEDGDDYESFRDKLVNATTKSKTGAVGKGPRFAVYDFEYQLASGEGTRNKITFIAWSPDDAGIFAKMLYASSKEAVKSALPGLAAELQANDQDDIEYESIIKVVSKGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTR5</accession>
    <name>A0AAE0NTR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_559043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTR5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="267" mass="29433" checksum="D9D685B18A0660CB" modified="2024-05-29" version="1">MQPPDRFVDGFPSLAAFVASDRDGTAAIFKRFNRLAARNLLLLQSELADLQAKLDTYDSEDARMETLQSLRHWADYKARATSNPSRMALVHQIRATLKEYREAMLFESTLAAIPPPDRKTLKAFRFNFFHGRPQTPEAFPTLGGNSCSLYDDPDDLVALHASDHRDRLTVFVQDNFGYLFKDEPVHGNSSSSSAVDYASGRKIASFIAYLSTILAALLLLGATIVLYNVTSDTLKLGLVALFTILFSASVGLLTNAKRSEVFGSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU66</accession>
    <name>A0AAE0NU66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_164409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU66"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="350" mass="38247" checksum="B5AE00AB9527065B" modified="2024-05-29" version="1">MSHIYDSTSDDYSSRHHRRRDDDSPPPRSRPRRSPTPAAMPRDVSPDFHSGGSIPYASGALPVRSASPYGQQQHTPFYAPPPATGGDTLRVPRDRDSRRPRSVPPPDSALLVPHRGRRDSYSNSSVDEDHDDEKDRDRRRANSPMSKARHVLQTTFSQSTSGLGVGVLGAVIGGLAAREASEKARQSQQGHHGRGGGSSSSHSKKDDHAALISTILGAAVGGLGANAIEKRVEKSRKKTKGEQVDWEKRWGRDGKDGPRGGERGLGGGGGGGDRDRDRDRGLDARDRERERERRGSTRDRDAVAGSGHRSGGTADDYYATATAANNPSDDDYVYDARRERRRSDEGRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU67</accession>
    <name>A0AAE0NU67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Soluble NSF attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_470736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU67"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="33118" checksum="2C3B36DF5B0DAD03" modified="2024-05-29" version="1">MALDPRALLAKAEKTLQSASGGFSFFGGGREDKYTTAAELFVQAGNAYKLEKLNKEAGKCFERAADVHKNKLNEPDDAANLMVDAFKVYRKESPEDAVRCVELAINNYTAKGNFRRAASHKENQGEVLEVDIGDRKRALECYDLAAQWYEGDNATALANKLWLKVADIAALEGDYYRAIENYEKVADMSLNNHLMKYSVKEYFLKAGLCIMATKDIVSTRRNLQRYAEKDPSFAGQREYQLLSDLTEAFDAGNQEAFTDKLFAYDQMSRLDKWKTEILVRIKDQIGEADNEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUG4</accession>
    <name>A0AAE0NUG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_448686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUG4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="631" mass="68998" checksum="E1B78C38041BD925" modified="2024-05-29" version="1">MASAAEKMSPLERKSSEGNSPVGVIDQEKMSHTPPGDAHAPYLDPFTMDEDYDGKPTEEELHTLRRVPGTIPIMAYLICIVEFCERASYYGVQPLISNYVNRPLPEGGNGWGAPPPNTQKTGGALGMGTKIANAVTQSFSMLAYSLPLLFGYLADAKTGRFKLICWGVGVFGIAHVLMVVAGSKDLLANGQTQGPYFLSVYILAIGAAMFKPNVSPLLLDQITTTVPKVITLSSGERVIQDPESTTERVMLWFYLMINIGGFMGVATSYSEKYVGWWLAFLIPLILYLPLPLLLWFLYKRMILHPPAGSDLPNVFRILGICFKRGGIKKFGRHGFWDLAKPSNIAAANLEATYPTDWNDQFVEDVRRTFQATGIFCFFPIQYINDNGLGGAANFLSTMLETNGVPNDVIGNFNSLSIIAMAPVLNYGLYPLLRKFNIHYGPVARITTGLAMSTLGGVGYTILNYYAYKESPCGEYGSSDCSVGTGVAPISIWWLAIPFAIGGISELFVNVPAYGIAYSRAPVNMRGLVSALNLFNTAVAYAIGLACSSVVTDPYLTWVFGGPAIAGGVLTVIFWFMFRHIDKEEYVLSHNKDYHLKLTGTANVVGENELNKSTNRPAPIAENEEMMISPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUI7</accession>
    <name>A0AAE0NUI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUI7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="119" mass="13607" checksum="6FBF0233995B5187" modified="2024-05-29" version="1">MECVSLIGKRYLWVDRFCIVQHDHASKQVQIHDMAFVYGNAYFTIVAAGASNAREGLRGIEGVSEGFLSPDPVYHNRYNIEELDHDQLISSSPWNGRGWSLQELVFSQRCLFFHKSNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXR1</accession>
    <name>A0AAE0NXR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_102538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXR1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="766" mass="83070" checksum="DB8C04721C1AED41" modified="2024-05-29" version="1">MEQCGCALGHAHELYARSGVGGAEAAERPPVYKAIGIALAIGSGLFIGTSFVMKKVGLIKANEKYNEVAGEGYGYLKNLYWWSGMTLMILGEGLNFVAYAFTDAILVTPLGALSVVITAVLSAIFLKERLSMVGKVACFLCIVGSIVIVMNAPQESSVANIQQMQKFVIAPGFLSYTGVVILGSAATAFWAGPRWGKKNMLVYISICSWVGGLSVVATQGLGAAIIAQAGGTPQFNQWFIYVLLVFIICTLVTEIIFLNKALNLFNAALVTPTYYVYFTSTTIITSAVLFRGFKGTPSSIVTVVLGFLTICSGVVLLQLSKSAKDVPDAALFSGDLDQIQTIAEQEQPETEPKADAIRGAAAIVRRLSSARQKMEMEELRRLHEDRLRESLEPVSETGAAPEYEWDGLRRRRTMASLRGRSGTMQSTSPFPFLSPVQQHPPLGWSHFPTEEELAAADRPSSPALSSIVGTIRNRARSVLLPGHPDFRTNPGPSRMQSPLHPVQLTEITVHPQKAGEDTAYPSQTHLAPGARSGTPRIGTPIREGSAASGSSSGRRVQFGGERRHADSETALRAPTPPPHSAKRQFSFQNIFRRHGNDQGGDGAQESSQRGNNRPILTPRGYSSPQNKAATEEERLGLVKGDSRYSQSVPALPRFEGEVEDDDDLTDNLDEKDALEVYKDNQESRYGPSITHTPPRRGSDEKAHELDDDEIAAYQQKRDRWFKERSRSRSAEGDDQSPPPPPEHWRQHRGGGSSGGGKGGGSGEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXW2</accession>
    <name>A0AAE0NXW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_104605</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3389823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="479" mass="50410" checksum="037A3519C705B6F1" modified="2024-05-29" version="1">MTGKEDHTTAVSAPGKVLLAGGYLVLDRAYSGLVFGLSARINVIAQEIHTSEGVHLTEIVVESPQFLEAQWRYGYHLADQDGGIKVTQLQVGSRIVPNPFVETTLNYALTYIAQAGTHKHKKHSVKSARLTILADNDYYSHQASAAAAAAAASGGGGESVSSSASTSSSSATPPASSINALNVSRFARFPTTLGDAHKTGLGSSAALVTALSAALLTHYLPLQILDVSSPEGKQILHNLAQAAHCAAQGKVGSGFDVAAAVYGSSLYRRFSPSVLASVPEAGSPGFASKLLEVVQSEWDTEVQKDAVSLPAGIAMRMCDVDCGSQTVGMVKKVLAWRAKEPEAAKALWDELQRRNEAVASVLRDERTGEISAALKAVRELVREMGTASGVPIEPESQTELLDALEAEVPGVYGGVVPGAGGFDAVALLVQDDTETLAQIEEFVESWSKAKGSQVSLLGVKGEMEGVRKETLEAYHGWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYC1</accession>
    <name>A0AAE0NYC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_537879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYC1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="32304" checksum="BD2C356A6FDE93EF" modified="2024-05-29" version="1">MAQTKGPGQGIFPDVVEITERLDEQHIFTTKTLGFLIHPNIPHASSHAKIADVGTGTGIWLLDFAKTVPSTCQLTGFDATPSSFPPPDTLPPNVVFKLQDMHLPFSEEEVGTYDVVAVRFVSSATTRTEWASTVTNLMTLLKPGGWIQWIDSCNFGVYNSVPGTSRKACREIYDGLEPFRTGKEDLVIGLMMRDGGGSVKREEIWRGLGLVDVHEDVFSTDRLQEPDLKLREKGTRNMIVCFTGCLESLVGKEGSDWTMEKIRKLEEEAMREIDAGVYHTLDQVCIVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYP2</accession>
    <name>A0AAE0NYP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_464720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYP2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="350" mass="37374" checksum="01D94D7744FD0667" modified="2024-05-29" version="1">MSSKGLVLVTGANGYIAARTVEAFLKAGYSVRGTVRSKSSSGANDLVTALSSYSSNFSLVEVPDITTPGAFDNAVKGVDAIAHLAAPVALNFTDPEPVMKGAIDGILRILESANKEPSVKSFVFMSSIVAVIGGIGSSKEGDYTFTEKDWNTQAEAIVAEQGKNAPGPVIYSASKTAAEKTLWKFRDEHKPNFTITAINPTFVAGPPLVVPSSTKEINITNTLIPDVYAGKPLDEAGLGAHVSHAYVDIRDVARLTVFGVEHPEKADGERFILASFYSPAQAVADILRKQYPERADVIKEGTPGVGYLPGYAYPSKAVYDGTKATRTTGQDYIPWEQTVRDTVEKLKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYT7</accession>
    <name>A0AAE0NYT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_492760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYT7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3390236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="680" mass="74681" checksum="E164A9EE00C434D7" modified="2024-05-29" version="1">MTSEAAAVAAPPADKQTITYRDKRYTTVKEGLAHILVPEPSADDKKRSADGQGVQQVFYNPIQQFNRDLTVLAIKAFGRERVECKKASGRARNERYAEKKRKRKEENGKTDVDRPTKSPKLAEDGAAVAPTNGETAAPADVEIQNETDKDPAAPKDQDQETEPAAADGSGAAADAKAADEVAEKPKTPFTILDALSASGLRALRYAHELPFVTSVTSNDLLLSAVEAIGLNVRHNKLEDKIKVVHDDALAHMYDVVTKDLRGRGKERTEKYDVIDLDPYGSAAPFLDAGVQAVRDDGGLLCVTCTDSGVWASNGYPEKCFSLYGGVPVKAFYSHEVGLRLILHAIEMAAAKYGLAMEPLLSLSIDFYVRVFVRIKKSPATVKYQGAKNMMVYTCDQGCGAFTTQPLMMNKRAPNKNGNGFFYKHGFAKATSSKTCDHCGYVLHVAGPMYAGRIHSPDFIQSILDDLPNASPEVYGTKERIKGMITTALEEVLSSPEELKAAEAHEEAMKTADRAEKKKLEAAARDAELAALDPYPFFFVPAKLSGTIHCAAPGERAMRGALVGLGYRVTRSHCKPGSIKTDAPWSIIWHVMREWVRQKAPVTEANIKEGSVGYRILRLGEKKEADVANPDESRPEKDEQEKMPEVVFDEELGRDADKRKLVRYQMNPRENWGPLNRALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZH4</accession>
    <name>A0AAE0NZH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_466037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZH4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="257" mass="26783" checksum="4B3CED81A4939981" modified="2024-05-29" version="1">MVGTVGADSYGAQLRNNLSAHGVDVSGVDVRDGLKTGIALIVVDKPSGENRIILSPEANHALHAKDFKTGGLTQKLGKVDLLIMQLEIPLETVLAALAAARKEGVSVLLNPAPAQRLLDAAYDGLAHLVVNETEAAMLGGVDVSVLDTSSGCESVARWFVEKGVRNVIITLGGRGVYFMNGGSSGKRGLVPAEKAKVVDTTAAGDTFVGQYALDVVVDGEAFDIEAAVRKANKAAAKTVERVGAQDSIPWRDELVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZI9</accession>
    <name>A0AAE0NZI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_429227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZI9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="542" mass="61023" checksum="31A0546AD13942B5" modified="2024-05-29" version="1">MALLFSLYKLAALAVVGAFASLVVAWIKRDRRLDKMPGPKGKYPFIGIGIGLPRKSAEVLGQWAIQYGEVYKIRVGWFDWVVINSPEAMRDIFDKQSVSTSSRSPMPLAHDVAVGGMRMNTLPYGKKWRAYRTIVHGLLSTTLTDQFNPSQEFETKQLLHDFAFNNEDGKQFYWHVRRYFFSILMTSCYGSRVDSWEHEDVQSAIHSTGLLSKISKPGTFIVDEVPFLAKLPAWLQPGRKLAESVRLPILNAKLKLWNRLEKQMAAGEAPMCYGRQLRETAKSWRDQGLTDEDFAWIVGGIADAGSGTSTVTFNAAMLYMAANPEIQDKCYEELMRVIGPDRTPGIADIPNLPYINACIKETIRLKPVPLWCIKRYADADVRYKDYIIPKGTVLLGNTIFLGSDPNKYDSPEEFMPERYLGFPKSSFEYAAGDQTKRDHFSFGVGRRVCPGAKLAELTLDLALANILWALKVEPPAGMMSVDAGPDAWDDTEFKAPKPFAVRFEPRRPDALTFTKRQWETAKREGYVLGNGKRVNVNGVMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P060</accession>
    <name>A0AAE0P060_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_557790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P060"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="112"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="338"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="645" mass="69952" checksum="618319F36C0A3D41" modified="2024-05-29" version="1">MMKGSLLRHAGVCRVALGARRVQIVSRASASASAFAYAPRGLVASSRPLNLLNTLRAYSSEASASRPEDSAPSGNITQFADLDTLGVHEVLVDTITKGMKYSKMTDVQSMTIAPALAGKDVVAQARTGTGKTLAFLIPVIQRILAVSPDLAFRGRSSARSDDIRAIIVSPTRELAEQIGVEAKKVCYGTGLIVQTAVGGTMKNYMLQKTRREGCHILIATPGRLMDLLSDPSSGIDAPQLAALVLDEADRMLDVGFEAELSEIIKLLPDRHQSKRQTLLFSATIPKNVVGLARKYIDGTNFEFVQTVKGDEVPTHEKVPQFIVPCKGYGNVIPTMLELIQRESTKAKNDLELPPFKAIVFLPTTASVQMIASLFRRLQYHDRTLPKPLDIHSKLNQQQRSRAADDFRASKSAILFSSDVTARGMDFPGVTHVIQVHNPPNREQYIHRLGRTGRADKGGQGWLLCGDLELSAARATLPGLPIQRCTDLECASVDLSAGEQLPEQFAQVKEAAGRLPGELLRSTYQSFLGGSMKGLDRQSLVDTLNEMASVGWGLEETPGITASLARAMGRHVQGIRILGPHEQPEDERRGGRFNGGGGNFGGGGNFGDRRGGGGYGGGNRRGGDRFDSMRQPEERRSRRPAFNDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P159</accession>
    <name>A0AAE0P159_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_467407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P159"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042094679" description="Phosphate transporter" evidence="9">
        <location>
            <begin position="20"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3391170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="700" mass="74956" checksum="2D3D6EE1D6244F0A" modified="2024-05-29" version="1">MQWLTRHAISGRWLLGTFTTLPGSLVHSQNRVDPTKPTPHPQSTLDTNLQAADIKSSPCRTPSSLWRYPRHPSTLEGSSTERHAASASRSPAAKMLDDYTYIFVIGTFFAMLDAYNNGANDVANAWATSVSSRSISYRQAMIFGTIFEMLGAITVGARTAETIKNGIIPTSAFRDNAGVQMLAFTCALAAASTWVMWCTRHSAHVSSTYSLVSAVAGVGVAVAGASNVQWGWNNGKGLGAIFAGLGMAPVISGGFAATIFMLIKVVVHMRKNPVPWAVYTSPAFFLIAGTICTLSIVYKGSPNLGLNKKPAEYVAGVTMGTGAAVGLLACIFFVPYVHAKVIKKDHGVKWWMFVYGPLLFKRPVVEVADQANVPDYAVVQEDEDDTPVAASNASVGDEENLKGANTPPSNPSHEKERQLVAANPEPVALTYKQIQEDGERKLKAKLLKKRGPIGWAMRTLRDNPMGAGQIYETHNIKMLFKRLPAQLVCGALYGLHYDIHAAQSGIAGTPEGERMARVYANAEKYPNEVEHTYSFVQVLTACTASFAHGANDIGNSVGPWAVIYSAWTTGKASSSSAPVPIWQLAVLSATISLGLITYGYNIMKVMGNKITYHSPSRGCSMEMGAAITVLVFSQYSLPVSTSMCITGATVGVGLCNGTLKAVNFQRVGLLVLSWIATIPIAGTLGGVLMALVLNAPHFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3M0</accession>
    <name>A0AAE0P3M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_386012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000037">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF168">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="87"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3392686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="604" mass="64543" checksum="FAC20A7076792B17" modified="2024-05-29" version="1">MESRRPSSERPDTRDGGASDFHSITPSCSTRSLTNHDHDAVSLPPPPVSLSSSSTSLSDEKAYAAEEAQARLPEAEVWVRGVGFWRCFIAVCVPILLSAFEGSVVSTALPTISQALGLGPDSSWVATSFLLASIVCQPLYGQLADIWGRRHLMMTAVVLFGIGSAISGAAGSGVVLIFGRITQGLGSGGIDLFAELILCDIIPLKRRGHYVAIKAAVYALGTTVGPVLGGVFAEGNWRWCFGVNIPVCLVALFMMWLWLQVSNGPQYDENDVPKSAMKQLARVDFTGIGLLTAAVVLILFAMSSGGAAYSWTAPPVLASIIVGGLGVFGFALWERCRWCAHPIMAPHVFSNRTTVAAFIVTVIHGFVTYGFQFYLPPFFQAVLGASPTESGVFILPCTLTIVVIAAVGGPLLAKFGKYRLMHGAGFVLMAAGFALCTISDQSSSVVLWILYSFLVGIGSGIIVSTTLPTVLVELTDRENAAATGSWAFLRGLGSLLGVAVPNAAFNAHFSTLLPSIQDKNARDLLANGRAYEHAQATFINHYPKDVKDEIIAAFSSSLRVTWIIFLVLACVGVAVTFLERQVKLRKELASDYGLKQRVEGRQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4D2</accession>
    <name>A0AAE0P4D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_457087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="792"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3393002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="890" mass="97406" checksum="295BBC8014D0A3F7" modified="2024-05-29" version="1">MPRVAQQPRRSASRTVSGSISASPFKSPVKIPLNDDAEEKARRSHGRKVLHEAQFNQLKAAATGTPARKTSVALNDIDNGGSPSSNPRTPGRRMGGGKENAMLVDDDDNRFVVGGTAVTPMKRVPILANFEEWMKMATDNKINAANSWNFALIDYFHDMSLLKEGDGVNFQKASCTLDGCIKIYTSRVDSVATETGKLLSGLADSRDKKKGREGEDADEDEEEEVDEDGNVKKKPKKKSQRSSEATLAPSFASLQLKKFELEFTVDPLFKKASADFDEGGAKGLLLNHLMIDSQGRIVFDSSDDANDMSEADPRARQRGSQVNDPEEDADMDVSGADLGTIHEAEEDDDEDIEIDIASLGARFFPDLARLEELDVCPSLKTFDLGDPSGSLDIPFLRAPDDWREEKEKTPGPGGVGNKSGMFIDEENLLGFDDDDGLGAFDLGGDVDFGEGGEAWAREAALEPQMMRVFDAGLDLGGSAGAEGDGDGIDILGSGNGGDFVVAMTSNQKADKAHEDILSYFDQALQKNWTNAEHWRIRKIKDVNKPAEPARQRKEKQPYEIDFMSPLEPSIAEVVYTPAATTSAISLPKKDWKSKSRNLLPDDKYFSSRQLLTLFLKPKARMGQRQSLKGGSNRGGVFGMPTDAQNANEVPEGEMDEAFWASQKAPMQNGDGAAGSANDETSALPQGDYDANFFQDDGLPFAGADDDDDIDEFADARDHFSPGPLGDNANGMLTEVGMTGAFGGLTVTNPADLAFGTMLVTQSRRFRPEYVQYARVAKKVDVRRLKEEMWKGMDMERLDKQQSDPNRSRLPTPPADEPPSAENPTLKFTDVMNNLQRVYPKTTMDDISTSYCFICMLHLANEKGLTIEKTPELTELIIRKDWTAEITNGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4E4</accession>
    <name>A0AAE0P4E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_9664</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4E4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3393094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="537" mass="60287" checksum="3A920054E1AAB8E7" modified="2024-05-29" version="1">MAPALKPPAPSRSLLRFLRAQSEGLTSFGLSHSAACAAARRCQKTALLSRRNTVADGRSNPHISVKSLTTSAQRLEATLKASAFDIESVLPKSLRKQRLISPPTAGAPRYASSDDRPPRGGSGRSTWWELLFGSSRQDASHLKEEDIRLNLEEENSIFPRRPLTAKAALDPRLRCTEVDGNGAVIMVDGELKKSELIAKYGLLPRDLRKIDSSNLPHILVRPSAILLNLLHLKVLIKHDRVLLFDIYGSKTSYPQSAFMYDLQGKLEQKHAPGANGLPYEFRALEAVLMSVTSELEADFESVREPIIHILSELEDVIDREKLRILLVLSKRVSTFEQKAKLVRDAIEELLEADDDLAAMYLTEKTHDLIRGEDDHAEVELLLESYNKICDEVVQEASNLVSSIRNTEEIIRAILDANRNSLMLLDLKFSVGTLGLAMGTFLAGLYGMNVENFIEETNWGFGAVTAVSAFFSIIVCWYGLVKLRKVQRVKIGGNDTRSDRNHWFREDSTDVLLDASNRERLRRINMMKNAKQRPKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4H2</accession>
    <name>A0AAE0P4H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_9933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="376" mass="43971" checksum="0C0599ED08A02550" modified="2024-05-29" version="1">MKLTPIKLRGRGRKKSWAPPNPKRFKRAAREDEEGQDSAIQRDGDGQQRQRKRIKAKKPGPRIEQLPAEILERIFIASENLNFPRSSLRIGFMLSARSLLSELLVAAFTPTWDLWFGCPKQLVHSYAGWEQDAARFGGNPNFQSAVLACSWANLSLLLDAQQVWYRRHGAGRYYQHIPDSSRIVQSLRREHLRRSINEERQFHAREGGFDHGKDVKNCFNEDWEEFKMIHQLTRYDFRFFVKHIQCNSSFLEIHPLTRIPNLLLTGPFDWEKAKWLYWLIRAGARLSHEQTWELTIRGYESFMKLDDPALALHLLPMFFRLGVFGLHWPEQLIEEKLDEALHQTSDGSMLADSARVWTTAENMIVFSIRSRDRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4Z0</accession>
    <name>A0AAE0P4Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_505386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4Z0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="400" mass="45858" checksum="89262064ADB52EFA" modified="2024-05-29" version="1">MASSGNPPSIQLPGDTFLSPIDVLPTQNEPHAELINRLKGQMLHVPNMLSLFPSWPSGRRNKNYKRLKASLDRISEVVFPDEAMRMKASKSDFALFSSIWFPEADWDGLYTCALYIFWIFHCDDAMDDKNGSVSEDFAASCRYRQQVIEYTRYCLGLDDPVSPQTSSISSSGWTPPCPSLPNSVFKQFGQRIQLTSSKAFREMFHRDIQLYLEHCEIEQRERMTGQIPPDMDNYMRVRHYTSGFRTCGYLAQLATGIRLPVRIMTSPQMQTLWDEITIIMSIENDILSVRKELAGGCIHNAVPVMFQQGQRALDGVIRELVARLENSRDRFDQTARKVYMMMTTMSGSDDDDDLVHREEILRYINVLQTNATATIEFCTFAPRYQNEKYLNVDGTMDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5I3</accession>
    <name>A0AAE0P5I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_505527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5I3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="357"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="525" mass="57740" checksum="DFC4AF1FCA410969" modified="2024-05-29" version="1">MLQPSQLCSRPASLTLHLSFPTTGLNLRKVQIQDQLLTNAIFSTMDSWEMPLQAPCDPFSDEASTPNKDNDVKSEVLSSTPNSFEVESLTTPFPALTLPDNDTDTNTGTDAHGKNEEESLESIATTSVTSKDNGSETSVKNLAASVVASQESSAKTHNSSHGNNSLIPLRRPMPVDPKAKDACLVGFYGGEKVIHIISPIQTMTTAGISFLDQKPDKLVLKDILTKSESEPNRLTTPSESPNAEKKTVGEKPLATNEKKTSDDKSPDNNESEKKLVHDEIPNTNEQNMGHNKTPDKDGEKLGHSMAPNTKEKKLVDKNTSDANKENLADCSHQASPLPTPPPSPNLEGGDQRHRYEEHFEIRPSSRGGLGAFAVKDLKKWDIVLMETPVLRTTHFGFTDDFFALNEEDQKVIRSLHGAKYPGDIQGIKTVNQFYVPEGIAILGIGSRFNHACVPVRNLRYAFDNNRNVMTFTVCKDHVPKGEELLISYGSGPVDLYNTYGFRCRCGACATLTDRDLAQIRKARYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5T6</accession>
    <name>A0AAE0P5T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_28487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5T6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="128" mass="14439" checksum="028336DE26DFA644" modified="2024-05-29" version="1">MSDENITPLTTEAEQSEEKNLAALFLQSLLNKNLRVTTTDQRMFWGSFKCTDPDSNIVLQDTYEYRQPTFQTLRKQTSSSSSSSFLEDVSGGGTVKLDMTSRYLGLVVVPGEHIVKMEVEEFASQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5W0</accession>
    <name>A0AAE0P5W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_459407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5W0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="23596" checksum="E1F1E4C8FF29318B" modified="2024-05-29" version="1">MAARGPPGARGMGSRFAQFKLVLLGESAVGKSSIVLRFVKDQFDSYRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKAWVKELQRQANENIIIALAGNKLDLVTEQPDKRAISAADAEAYAKEAGLLFFETSAKTAENVRELFTAIAKKLPLDQVGPRSARPGQRPGVSLAPEGANTQAGGACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6U9</accession>
    <name>A0AAE0P6U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_444270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6U9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59266" checksum="6DD8526FC3A5AC65" modified="2024-05-29" version="1">MNGSFGHHPPSRFLVDGNGDGFHQHSENGGGHHLSMDFDMMPQHQSQHQHQQHQPSSDNGGGVARLPNGSASYESHDDLCIDQCSGVGLYNGSGFFNHRGAPAASAFPPRWPGRVAPAPAPGPSRDTLPPLYHYTMGLDDLSMQFRPSPDPYQPWFVQQLQSGLHASDDDCRSMGDMSCCDSQCTMTGKCTNMACANKEDACTDQSCPGRPESVPSEVVDGAAALISINHAPEQQQPHRFGFQPSSGSYSSSPAPGGALARVRGQVMDFGTDFLHDPNWRSLLGGLASHILVAHPIEDTANENCTRPCPLDDPRNYLNCHIPAVYNNPPPFSHYGSGNGAPMLMSRELPVCGAETDDPDAFLAHFNTQHRPFFTGDPQSLMARLGCGDEAILPSTEDRSPSSATPLDTTDSGISSNTPDPLTPLSNSMDMSDVKDSASSLSRSQSVSSSVGTPVGTGPDDEHKCLWQEEGSTTICGRIFEDSGELFVHAADAHIRVAGAVGFPQRSKIERHMQTHIGHKPHICPTCHKGFSAKQALNQHIILDTPVLSYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P707</accession>
    <name>A0AAE0P707_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_49083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P707"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="312" mass="33064" checksum="083BCCB2DCD317F7" modified="2024-05-29" version="1">MGDDAPERAAKGKGRATADKEDNVQQENASSSLSALSRLAQSASSLPTALFSGPAAAEGLSSLGSSSREKGGTPQTSSEGASRAGEGSAQMRSSLPGSGESLRPNQTQQHIAQEDASFAAFLDSTPVQIPTEAAWQSTSSQSTGLSSATSIAHQPPQTVTEQQAHDGSDVVALLLADGVLEADFSPEETISPEAMSKLRNALFGESVRSVAWDNVLNFIPPYLASTGDKREANERQAHLGTANGQDAWQMWTAQWSEVLASYQDEVWGDLGALVKDARLEVLQLEDTPQDRRPPEPTALLRLRAILNHLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7C1</accession>
    <name>A0AAE0P7C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_54289</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7C1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="428"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="182"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3394666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="487" mass="52362" checksum="82314A9DBFF7994D" modified="2024-05-29" version="1">MPRDDLSIDFVRRMPPVEALDPAMILDEWINRTQNLPEEIRFLQDEIADKDRQYDKCVKEIEDRDGRIQKWIKANGSHQQNPKEEEYRATIRKNFALAEKLANEKIALSTKLQQTMDKHVRQLDMQIKLLYDRAEPGFQDPDELPSLLRPSAANITTTPVMRPVNATNPVTSALNALVNNTSQPSVRTSNAQIRNAQSQQHASASAPATPAASMIMNRGVRESSAGPGSGVPKRGPRSNSGIGNQPATSSGLARHSSLGPGTPKGVQQTAAGVPRAGSAGPRTAKGAGAGGSRKAGTPSSTGGRNKKSTSATGNGSNKSKLSQIKRASKNSPSSAAESELSDADTGSADESDARTGGRGTPTATSRQGSNVANMGNNNNNNNREEGTQEREPGSGPGAAERPRKHKRGVEDDDENAMDVDDDDAGDDKKYCLCQNVSYGDMVACDNDNCPYEWFHWNCVGLKSEPNGTWYCPPCAETMKFKKGRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P829</accession>
    <name>A0AAE0P829_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_426949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P829"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="317" mass="35359" checksum="2B76DB94B8958F5F" modified="2024-05-29" version="1">MKSIGIFPASGGLGGSTYRHLLEKVPNEKVVLISRHPEKIPEKYLKAGVQTRQASYESSISDLETVFAGIETLFLISYPSHVREYRIKVQLPAIDAARRTGVTHIFYSSLAFGGDAQSNHSVAEVMQAHLATEAYLRKLASEDKSFTYTILRMGLYAESTPIYTAFFSPKAQPTVSEILIPHDGSGMGIAWIEREELGEATARLIARYAEEPDTFQFVNETVLLTGTKVWTLEDTVKVLAEIAGTDIKIREVSVDEYVKLKQVQEIFGSEEKARTWSTAWEAIRAGEAAVVTSQMEEILGRKPEEFEASVKRYWGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8E5</accession>
    <name>A0AAE0P8E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_492189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8E5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49227" checksum="CE7928F0684E2BD1" modified="2024-05-29" version="1">MANVYKFAWLNIAALSTGSDYEGFINEAREPRAIFGFRASFAAIIGTGSQDINRNLQGRPCVLLDGEVTLLWDKQSDLPGGGDWMAPLFTRAWVYQERSLARRTLAFATHGVFFSCDEAYYGRTSTFCAVAAALVDEALATGNAPSREQLQMEARDLLSRFDATWNGAVIDYTKCKLTKDTDRLVAISSTAHEVADSGIPREKRYLAGLWDINFISQLRWMTCEGRNTKPRKRIGTDGYVAPSWSWASIEAPVATCGAFYTDDKPIRFLADVTAADVKLATEFPFGAVRAGWVRLRGCLRAVSGSETHGTMGGTSLTDEATGENLWFASDTTEGYEMVASSAGLRKVVWVPHVLTALETMVECNVLVLSELSPDEETGDDDGTFIKPGEKVYRRLGMGNFGRIPSLFRQDKLLMAMGTYPEADEMEDIAREFVRNEVGFREFVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8G2</accession>
    <name>A0AAE0P8G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alginate lyase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_518039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8G2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042103387" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="183" mass="19382" checksum="55BF4CDE7081665B" modified="2024-05-29" version="1">MARTTIILVVSLYLNAYFKLTLAACPKDILDLRFLQLPTGRPGSPDSIQTSSLEGCFSNGNFFAGGDNSIVMKVPGTPANSGCVTTPNSLHCRTELHETSSWQPTSAVNSMTADLVVVNAGGSTCIGQIHIDESLSTKPALQIYYNSNGAITVGVERQRSGGGQVITPVGKVSPGVRFSYEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8Q1</accession>
    <name>A0AAE0P8Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_427127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042201761" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3395100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="274" mass="29239" checksum="716446B999D3539C" modified="2024-05-29" version="1">MATIMTTIAWAVALLATCVHAHVVITYPGWRGNNLIVNESFPFGMQWIYPCGGIGTTTNRTYWPLTGGAVAIQPGWFQGHSQALIYINLGLGEEPKNMSMPMTKFHITGPPGNLPYPDTVCLPQVPLPKGVVPKNGDLATIQVVEASIHGAGQFSCVDIIFTDDATKLPPLNETTCFNTTRLIADSYNVVPDRAQDSFCKYVGNKEAGNASATWDWDPNAPRTGSNGTGTRVTGGPLPATSSTVPAGNGVGKMGVERVELVLWGVMLGGLYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV82</accession>
    <name>A0AAE0TV82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint component mad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_194591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV82"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3380934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="238" mass="26127" checksum="8A1FD9F7F09DCB12" modified="2024-05-29" version="1">MASAAAATAAAPDKDKSKVHKLSLKGSAKLVAEFFQYSIHTILFQRGVYPAEDFSAVKKYGLNMLVSSDDQVRAYIKKIMGQLDRWMVGGKISKLVIVITNKDTGEHVERWQFDVQIFKPTKPSKSSKSKQPTPTDSSENASPAAAQPVPTAEKTEAEIQSEIAAIFRQITASVTFLPQLAGDCTFNVLVYADADSDVPVEWGDSDAKEIVNGERVQLRGFSTANHRVDTLVSYRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVI6</accession>
    <name>A0AAE0TVI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Necrosis inducing protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVI6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042239496" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="276" mass="30603" checksum="C4AF9538A3020F20" modified="2024-05-29" version="1">MHSLATILLIGGGLLSAKATPIATLQDFSEEIANITARDLRGSLPVSASTLEHRFQPVTDFDTDGCYYTSAIDPDGNLNLGLSAGKGSHPSCLAETCRDPNRLENNNVYSRSRCNNGWCAIMYEYYFEKDQVVCGSYSSGHIHDWENIVVFLRTSDQRVTRVAPSAHGNYKGATNSPRMLGERAKVVYHKDGGFTHAWRMAKSADDKIENYTGEWFLGRLVGWEYWPSNSLRDKAMSVDSWNVNKAHPKLSDAKFDENLKKAAGDQVPGFDPKVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVI8</accession>
    <name>A0AAE0TVI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_474897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVI8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="740" mass="83144" checksum="AC15AAFD81120AC4" modified="2024-05-29" version="1">MPRAARKPQGPPFESSKRLPVNPRRKKVEPDQRKRVQTACNRCNIKRIKCSGHDPCQQCLNAKGEGEVCQYPVSAPKKTVLEAEWIEVHEKVANLMERLARYESFTEEERAAYGRRLSHDEQDERVPNPYQEDQSVARQQHEHPNLVPLVPYPPAIDPALTAQSEMEVDDNLVRTEGQLLADEDGNMRYMGETSGATYLDKIRVFISASQILATGTSGSSLNKTGHYQTFDSRPMRLPKVDANVSPPRAQARGMLGELSTFIQDGSGHFASGGILFWPLGTSMPAARRSSRRDAAPYHVAFAFHTLLSLTEHGSQVDGQLGEEHFARARELLQNPLDGQLQTSNDIAALALSALYLVENNRRDAACIAISNAMHVSVVQGVHRGLLTDEKSRRTFWTVYILDRWLSCVLGRPPTIPDDSIHVDEPRYCPGLPSPVGLQAHVELSRISNKIVVNSYSRLQGNCDYVDTAIDLLHEWKAKLSPVLQMGEPTVPTLGDLEDLSSYEPLRTPGDDDRARYSLHMAYNQLVILALRPALLAAVKKVVLDGVWRREWNIQSHPFYARIDDCSKAARSNLKLACWIRVISPKQKLLLADLHHIFNAALVLLLHQIGFSNMRTMDSRLIDFAITVFEKEAGTGNGNSIECIRILKDMRVLVRRLRARLYRDDPDQTGPLEVEKYLIYPGQNNFEAGALMGDRVDELNKFLSQLKGFGSEQNGEGKLVKELRSWWTPDDEEGHYGIDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVL9</accession>
    <name>A0AAE0TVL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_545698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVL9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042069251" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="38"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="357" mass="38760" checksum="FC20CC0A54A1A585" modified="2024-05-29" version="1">MWKFLAIAAVAAQHVSAQGMSANMLRFGCSQLVIERADPIVNPGMSPSAHTHQIVGGNSFNFSMDPADFDPSKASTCTSCTYSEDFSNYWTASMYFKSPENGSYRLVPQKANFRRPNSPELLPQEGGLTVYYMQPFGGDPKTTSFKPGFRMTAGDPALRSKQGTYPGICHRCNGNGEGGAPCDSKDSSEFPAKICPGGIRATVIFPSCWDGKNLDSPDHRSHMAYSGRSALAGASCPSSHPVRVPQVMYEIMWDTTPFNDPKHFQNGKQPFVYSFGDGTGHGQHADYLFGWKDNALQRSMDELGKNGCTVDVCSSALKIQDGKDAIACTKAQQVNENVGTKGEWLSTLPGNPVVTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVU2</accession>
    <name>A0AAE0TVU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_560949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="417" mass="47430" checksum="505928592FD54E46" modified="2024-05-29" version="1">MSSLTRLNVILNEASYHHRDPGIDVTFGIQISTATHSSALLPLRSQPSQQFYDLLDEWHVTAAYLSSHVGIGRLELSLVCDRECGECECLSSPPKPDKTSSALTDLPRELRLHILEYTDLITPWKEVSWSRQGRGYMVFRPYCQLSHEQACPPDVHHGCKLYRCQGDGPSSPGCFCRCRHAAFSLACKCWAPPTNLFLLFHFLTRDAQFVFFSGNRFIVHDFHADPSWDMQSDSRLEPLVRGGGGSPGTTEQYYYYQYEGFAASEFLQDVVLTHCLADLCFLELIFLLYGYYAWPHNNHAPVLDWRATVGTWLQGKIDAPALTIRLVMVDDDDDDGRELTGEQVQDIMKGRACIVGPRDETPGAEGHGPEWLENAEQHLKKYNERCIWVDHPRPNPGHRAEPPKSVWQRIYEADLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVY6</accession>
    <name>A0AAE0TVY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_416347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1824"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1953"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2103"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2170"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2017"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1609"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1953"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1963"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1979"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2180"/>
            <end position="2192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2254" mass="245093" checksum="1A2CFE58F3A3D96E" modified="2024-05-29" version="1">MAVEGATQALVAAFTFGIVVNAASAALFLCIKGHGTSIFRDSPRLVLILFLLSSALWAQVDFITVLLDISKSSMPCQVGVIFSTIFDQLGRFSIEQYLIWAMNDGTKISPMQMIPQLLILGRFIAGAVFVGFTRPQTDTFCLATSSALPISILVIALDAVILLLLVVRAFSTGLVANIQKGGSGSARSKSFMLVMLGHAIWTATSVTLLLGIRTVDLIARTAVPAGGLVTLIIIITACVGSLSTPKGSSSRPPEAPSPRRLNISRDISTSDSDYPPSRYEDIKEAAIRSSTTFVNPRNVPIVKDEAGIGGLPIVARPITGVAGMGGVPIQGELFPPPRTETVVESGRASRKLETSGSQKWKKNLFDFGKGGPAAALSAGKITISHPILQDDDPQNPLKKIATIGLEEAARAEKERRTKAQVDSAAVINRPAPLPPSTNSEESLKRAVSFKRKEVASVSLQPSTFPMALQPDNGALSTSAQLSPGGDEVRRRSPRQSTQDQSLLIPAPQPSQVPQAVQVRPESPLRQEPARTLIALPQQALPRPDIRPSRALIPSPEAPPEPPKNPLQRRPTIGLPSNPRARGLKVAQEAGAQQQQTIMFVNNITYDDPTGVQTIIKGANDMAANDRALKAASAALPDSPGTARSVVNRPRPIPRKAPESPAQASPAVNHRRSKSGGSLVRKSILTSTPGSPTQLPPLPLPPPPRSAGVGLRPQPNDTKSMTFDEKMAMFFPAPPNGNTVKRRSSVPELPPIPATYLDMNSSPTESERRRSNRTTKTSIRTGSILDVDEIPKNPAGPPQLSPLAYTGVADEVGNSWLPGISMDDGNNKALGKQNSTGSEGKRASSPLIPPVRSSAWTESTETRTRYTRDDSTTNWGSVYSPELAVSVPVPQMAYPTAVQKGDRRVPAGSKANAPLTQNRDSDVLPIMFDVAPIVEAEPMVKPERVSQPSWHRRVGDDCPTFSEKARSRKMPPPSPLTLNTFTKKNTVIIHTEPSPFESPEQALQKIQAQLKELEKADRNSLESPTRRLALLENLEKEMGVQQDHWQEMKHDIGRDSLSSIQTTSPVNRNSRVEPVAVNLAQELSSVRASIGAERRASRRARVRNSGSAKPKETSVHSPEGSRTNNWQKRLTEAQAEYMDAAAELLRTRGVNFLSMSNAQLGSPTPPDSHSDTDEEVPRLPSRLGPVATQQSRKQPRRALLWEPAQKESSSSTSLLWAPTPKMSSEAELPPLGLPESIRRSAPRKEELAPLPIHSSQLWRKPHRNVASATTGLWRPPWASAAPPAETVRLSSQGMSQSQSQKAPRPLTQRPPRRNKRVTLLPDILESPQPLPDKRGTLGIFQFPWGEKSDTASMQPRPSRFMAMPGTMTSGGTSINAAAKQLESAEYSSSFFDDYDDDENDERNSDEGDGDDSDDGFDETTLWEIASLLKSDSVPSKNSMFPPPTSSSVVDDYLDDFPSDDERRSSREQSIMIGLAEEPQEVLFEQPRDSMMPDGLRRKERISVESTTLPSLENDEDDETGESIPLLAAAKTHPKPSMIPRPAAPAVVEVAPEPAQASAPVLKSSMIPRLAAGEIKKTRKARKQVSAGLWDLPAQPKESSSSSEGTLFEVDPSRSDYRTTSEEPAAKNLNRKQRPSEPKPLEDLSSKTLWAAKGDAASVGLWMGMSSPKQDGRLWMNRTLQPKKSQGGMFKVDPTRTDYRTTSSEPAAKVMGRKHRPAELKPLEKLSSTALWAAKRDAVSPGLWMENSSLNQDGKLWINGKPTSKKAQTQGGMFKVDPTRADYRTTSSEPAAKVMGRKPRPAELKALETVSSSTLWADADAPKEGGRHWISSVSRSSTEHKKPASRADWAAALKDAVSASYPITKPAPATPAEWDAALQEAISLSTRQLAAPFDSATRHPVFAAKSLVTRSEWFHPAATGYTYDVANVHPVFFGSLAITCPEEAVHPAMSAYAAKKLRRQRSRRSTHDRSESRSRSLSRTDSSRSRRSKKDEIIAQIRALEQEDSDVLPPVPRVPTEITAELMSRNAMIQAQVEALEQEREWVQRAAQEDYNRRASRGMFAQPLVSEPEPMPEASWQHRASMGVQTIQDLQRHLESQDHIRQSLMWTDPPSSSLSANTTIKSSPSSPSREPMAEGAKKQAAQMWSAPAKASPTNASTGLWPATGQGLAAVAAPSEDADASARRARGRKSKQKKERRAEILAQIAAIESGSNPNPFAHYQHQAMWSLGASVRSKGGGRKNWLADSKANRVSRVALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW29</accession>
    <name>A0AAE0TW29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_211954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW29"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="274" mass="28858" checksum="ED7EF7036DFECB39" modified="2024-05-29" version="1">MATTVYVKNIAAGTDDKEVKNFFSFCGKITSLELTPDGATKSATVTFEKETAAKTALLLNHTKLGDTEISVTGGSSDSSSSDDEHTSTQRDTDELTQEEKPRARILAEYLAHGYLVADTGLKSAIALDEKHGVSQRFLGTLQNLDTKLHATDRAAAADQSYGITNRANSLLTGLGSYFEKATHTTTGKKIVDFYTAGSRQVADIHNEAKRLAELKKQEAGGSSYKAAGLDKVFGAEKPAATTTEPVAPANAAAVESSQAPTAPANVGGTPSKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW52</accession>
    <name>A0AAE0TW52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_476663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW52"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39101" checksum="B91C9FED1DE1C659" modified="2024-05-29" version="1">MTGTRLLVVGAKMDNADFDFDFDLLFGADEYGDDTSPFTDSLDSSPENSFAPANPDPMRFEPTIHAPSGYEMPFSNAGTQLALSQDATPFGMPTFPPSGQCLFATESNPMPYFPNFNPLTLPAQDNAFQHADGLPMSPQFPAALPVFRPQEIITHPQSWPEADVAVVPDASVSPALTADFSLPFSPNAAVAFSSPPDMPPTNTTTMSSGGNGARASRLPPKPSVRGSGSTDSQMASSRKRSLSAITDDEDEASPESPSQSQSPLSQGEVRPKKGREWYNAAGKKYRDNLSQGYDRLNDVLGTPKGERDRPRAKVKTLHDAADRITNVKEQIRVLKIESEQVRSKNAMPTGLGLLPSVSDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZS2</accession>
    <name>A0AAE0TZS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZS2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290101" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17089" checksum="27AF8AE97CFB2A77" modified="2024-05-29" version="1">MEKVQIMLFCLLLLAPSELAVREHHTLTSLEASASLKPCARGCIAYGSNTGCWVNAIASLEGCDWTCDPATGGVKDECYCRKDLMPAINLHLSNCIKAASTMGDYRVDLAPALTLFNDYCAGSFTIAPLTTTTASTTTSSAIPTTTSSTAVSTTAATTVPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZT4</accession>
    <name>A0AAE0TZT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_186703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZT4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="538"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="851"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="875" mass="96712" checksum="BEB2794600C580A9" modified="2024-05-29" version="1">MASPAKKRKLNSGAKQTTIPARGLEYFFAKQNKNGSSSKPPSSSQASESNAEPSEGQLTDEELARKLQAEWNAEAKAATKDDGNKSSPKKEPSVSAEPEVSESTSSSKPVQRPSPLPKTQVANANPSLSLSSVAATEDQASALIPLDESPLTFDPSKHIPQLRESWASEGGDASYALLTRCFVLVNGTQSRIKIVDTLVNCIRVLIEGDPSSLLPAVWLATNAISPPYISMELGLGGSAISRALKQVCGLDSRSLKAIYDRLGDPGDVAFEAKKKQSFTLRKPKPLTIKGVFQSLIKIAKTQGQGSGDVKQRIVDKLLQDARGGEESRYIVRTLCSNLRIGAVKTTLLIALSRAFLLSKPSGADFPTRNPQELAKLKKEELAEVWSKSEEIVKACFARHPDYNDIVPVLLEIGVTEELLIRCGLTLHIPLRPMLGSITRDLAEMLTKLQGRDFACEYKYDGQRAQIHCDANGKVSIFSRHLELMTDKYPDLVALVPKIRGEGVESFIMEGEVVAVDQSSGELKTFQTLTNRARKDVVIGSITIDVCLFAFDLMYLNGQPLMDRSFRERRDMLRSLFVEIPYRFTWVKSLDATSQESEVVLDFFKSAVESKCEGIMVKILDNLPELEYGGENTEQTEAQVPTEKKAAKNGNKGKGKATTSNQEPEKKRSRRKPLLATYEPDKRLDSWLKVKKDYHASFDTLDLIPVAGWHGQGRKAKWWSPILLAVRNEETGSLEAVCKCMSGFTDAFYKANKEFYDNGEIGEPKNTHAQKPSFVEYDGGHPDVWFEPQEVWEMAFADITISPTYTAAIGLVQEDKGLSLRFPRFLKKREDKGIDEASTSEFLAALWRKQEAKGPAAGKEAANPEEEADEDDLMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1C2</accession>
    <name>A0AAE0U1C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1C2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="94193" checksum="1E10EFBF0F72472D" modified="2024-05-29" version="1">MPYSDNLYSMVDDESDFEDDLNQLEPRAQGSSQSQQPRNDTGASAHPGISGLDTSFGAADASNLEAAHLSPANGYFHSATGAASNAPVTATSSNVPHVPNVWVEDPSLQQRERSNAESKAREAEEERLANRDHPLTAPRHTYAGIDHSFRTAATSRSNPSSAYTTSAPSHRGSGLDLGSNSVLAAYPQPSSSSSAYAPSTTPSYTSYVPRRAAYNGRSSFMPREAPPAYTPSPTSPTSNQGASDASARNYSTFPHTPLSPSGNMGRREESQGLLAHDPESMGGPADNADDDAPLLRDRLRKRVSSIKWRSRRGILIGLFIFILAAGFFKKHNSDKLPFKDRPIKEPVMDYPGLDDEFQWRATHLCKGVQIPRRDEQFDISFDSSKQFILIQDIDNGRGDFDRNIYVQGTVILRRVGDGTPGPSIIVKTTVNDDRISVVTDWNVDQQALRVTVPRGMSWVEADTGPCVNIMVTVWVPEDASLTRLDVETIHLDIQLMDNLSLNLSQIARLSSVVGSITAASTGNDAQDDNIIDVGAPDSFKLNSRYIEVKTTSSPIKGSWPLYDYLGLQGTSGNIKVCIEPKEANKDAPKPAILYVKSLSGDVVLREPIEAASKAWALSSETNLRAETVLPPRDYRVDIHTTSGNVKGSLAFSSQCNIKTTSGKVTPNFLPVLDSSLANEGSKEVYLSTSTTSGNIDVTVLEPLWVNGSKGEYTNGPSPPQPPQPPQPPRPPTTGGEDHRSQPTPGKEHDGEYIPIGKIGNGDPYSSLPGPVQPQRRGIEKVENVAPALRCLYAQLTATSADMRLRLPSVWEGDLVLSTLSGNLRATGEGLHQIKPGSDWSGRKTLTSRKGDGGGNFVRAKTTSGDINVQVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3Y3</accession>
    <name>A0AAE0U3Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_538088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042202678" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="83" mass="8963" checksum="12A7DA4CD88EB29F" modified="2024-05-29" version="1">MRLFIQLGVLCLALMGVSADELEDKCPKNELACHDVMNSSQCIEQLVIENQAPLTKAAMVKCVEHEGTASNLPGATKVVIPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U460</accession>
    <name>A0AAE0U460_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U460"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="35650" checksum="A5F1E605DCCFF58B" modified="2024-05-29" version="1">MVGLFSSTRGASKPPSTSGHTYGRIPPTALTRHNLTTSSRWQANEATTSQDHPSLPIQLSKGGELPDDLWRCCDDIITVVGKADGTKERPDYSARAGLWNAVFTNGWNTDCPIHHPGPIRTHRVVEVMTHIGTSKCNLPPAAARETSSKKRRRGEEGPCSSVGIISKHRVAEAPAYIKPNIEYDEYFCFTVTFSVHDAKGASAGTGAAKSIALRRGWTKQQALAEAAMNWDEKEVERVVGYNHKLAVFWARSRLVARLRAAQQSDGNDDEDAEVGVAEGVEVNRRKFVKLETVADKMKNTASVVHDANIISRPIKKRRLEDIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4J3</accession>
    <name>A0AAE0U4J3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_122612</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4J3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="317"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="575"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3390758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="663" mass="73955" checksum="D6430E092D49C291" modified="2024-05-29" version="1">MSWKLTKKLKETHLGPLASTFSRTPSTSTITDKDDKLQSSISGTATPTNVSTIGRLFPTFVSREMFEMRNSSTTEASEALTQAPVVTTPKPGILVVTLHEGQGFSLPEQHRNSFNPSHGGNSLSTGNALSSVAGSVRPSSSSRVGTFMSGGRPQTSSGGFNGIPTNHGRISTKYMPYALLDFDKVQVFVNSVEGNPENPLWAGSNTQYKFDVSRVTELAVHLYIRNPNATPGSGRSQDIFLGVARINPRFEERQQYVEDPKASKKDREKAAAEFANRERALGQSGVEWVEVQYGTGKLKIGVEYVENRAGKLKIEDFELLKVVGKGSFGKVMQVRKKDTSRIYALKTIRKAHIISRSEVAHTLAERSVLAQINNPFIVPLKFTFQSPEKLYFVLAFVNGGELFHHLQKEQRFDVNRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYQGHIALCDFGLCKLDMKDEDRTNTFCGTPEYLAPELLMGNGYNKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILSEPLHFPGPEVVPPAAKDLLTKLLNRDPQQRLGANGSAEIKAHPFFHAIDWRKLLQRKYEPQFKPNVVDALDTANFDPEFTSEPPQDSYVEGPLLSQTMQNQFTGFSYNRPIAGLGDAGGSVKDPSFVGSIQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6I6</accession>
    <name>A0AAE0U6I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_456600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3392781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="353" mass="39085" checksum="2CBD0E271B9D03B0" modified="2024-05-29" version="1">MSDPVVATAYDPKGMKFRYLGNTGLQVSVFSYGGWLTIGGTQKGNVVKELLKAAWDNGIQTFDTAETYSNGASEVEMGQALKELGWPRDEYVLTTKVFFGTGRKEPNTRGLSRKHIVEGLKSSLARLQTPYVDVVFAHRPDPATPILEIVEAFTQTIRNLNLAYYWGTSEWSAAQITEATLLAEKHNLIAPVVEQPQYNAFHRERFEIEYAPLFQQWGLGTTIWSPLASGLLTGKYNDGIPEDSRFATNKAFFENTVKELQSEAGQAKIEKVRKLTAIAGKLDAKVGHLALAWAAKNPNVSTVILGATKIEQLLDNLKALPLIDKLTPEIMEEIEAVLDNKPKGPATFGRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6K2</accession>
    <name>A0AAE0U6K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_424631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6K2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="439"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3392826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="58455" checksum="39B8D6F8430D1779" modified="2024-05-29" version="1">MPVTDIVSFAFDRQRQYDEEKRLFISAEDPSQFLTANQTVALVRKLIAGLQTAGLQRGDAVLLHLANHYMYGALFFAIIGAGGICCGTNPAYQAFELNHLADLAAPRFIITSEDCLAVVLQVCKRKNIDHTDVFTIDSACRSAAGVPPSVPESTDLEGIRPLTDLLKYGEADWIVLDSTEDMKKTMACYYSTSGTTGLPKLAMFSHYALVAQQVALQPADVPFEVIRLACLPLFHVFGAAWALFSTIRMGQPVLIMSRFDLASFVGSIASHAVSETYVSPPIVHSLNRSGLPLHELLVTLRYVGVGGAPINAHALGNLKGRMHADATVSQVWGMTEFGVATLFPWGEKVDGNAIGRLLKNYDMRLVDSEGAVITSDGKSGELFIRTPGVMTGYRNMPAVAEGEWFRTGDLAHTKDGVLYVDGRAKEIIKVRGWQVAPAEIEAVLLQHPHIADCSVVGTTTDDGLTEVPRAYVVREKRPQSAVLTSAEDVFNFARQRLASYKRLDGGVVFVDGIPRTASGKTQRFKLFQMQAEAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6X3</accession>
    <name>A0AAE0U6X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_12668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6X3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3393186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="16865" checksum="D58C6FD11DAF2830" modified="2024-05-29" version="1">MGRLHSNGKGISASAIPYSRNPPAWLKTTPEQVVDQICKLAKKGVTPSQIGVVLRDSHGIAQVKVVTGNKILRILKSSGLAPELPEDLWFLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLARYYKTVGVLPPTWKYESSTASTIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U788</accession>
    <name>A0AAE0U788_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_491486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U788"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="56189" checksum="57B8E3272DAD478C" modified="2024-05-29" version="1">MGIADKRWWPLKALDLAPRRFWNTVKENWYLGFTAFGGPPVHFKIFRDKFVTKLEWIDEQVYQELFSVCQAFSGPGSTKMHYCVNLIHDGFLPAVLGFLIWSLPGALGMFGLAIGVSNIGESLPRIVYALLSGLNAATVGIIALAAVQLAQKAITDKLTRLLVFLGAAAGLLYNALWYFPLLMLAAGIITVVYDFRWLHGPVRMLQFRRKKTRSVEAAEAAEGQQGENDLEMSPQGGEALQTTSSSKAGNDNDNNNTNTRQRLPVTNQEAATTPNAGEEAEIHTVPPERRLNMSWKAGLSIIILFLVSFTIVMVIRGVLPNKPLLYSLFANMYLAGTVIFGGGPVVIPLLREYVVAEGWVSPRDFLIGLALIQGFPGPNFNFAVYLGALAAINFGHSAAAGAVLAYIGIFAPGLVTVHGTMGVWGAIRSRHGVKSALRGVNAAAVGLIYTAVYRLWQIGWIDGGFQRGTSLANDPWWVVVTTTSYVGGCWFGASPPVACLMGAVLGLVRYGVVVKGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7D6</accession>
    <name>A0AAE0U7D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_458605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7D6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041775201" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="36"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="339" mass="38963" checksum="3A183E6EE65E49B2" modified="2024-05-29" version="1">MLAFSWGRRALSQQHAAILLLSLLCCLLFPGPATASVGDRLPEFGECVQICERENCGPDAEHLTPIPLLHRLLLWTCPAECDYTCQHIITARRLAANPPQPVVQFHGKWPFRRVLGLQEPFSVVFSIGNFVAHYNGLRNKVLAHIPASYPLRRFYVILAWVNMATWFFSTVFHTRDFAFTEQLDYFAAGASVLYGLYYTTVRIFRLDRPSRYRALRTWTLVCAALYMAHVSYLRFWRWDYGYNMAANVAAGAVQNAMWSWFSFSKYRSSRRAWAVWPGIVVAWVLMSMSLELLDFPPIWGSIDAHSLWHLGTIAPTVLWYNFLVRDAHDDMAGIERLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Y5</accession>
    <name>A0AAE0U7Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_459524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7Y5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="59" mass="6451" checksum="51D4689B3BF13BF2" modified="2024-05-29" version="1">MAEAIKHAEETERHMAMLEQWSLYKQGSAQAMAMAKHLGSKADSSVLFEDIANTIDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U815</accession>
    <name>A0AAE0U815_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_444081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U815"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="37123" checksum="C265C658E19D535E" modified="2024-05-29" version="1">MPSDDHTSRNKRKPSDSDAELGSISRRHIEPPPPPVRAVNASAVHFSGLESGLDAALRGIPELESRAAYFHFRKNGADVRRSNNLENLVEAVKQAYQGGGPGSYVVVVKKVAEPQPVADDDLPGLRDYGIALPCNHKHRIEDADMPLHSPVGPINSNDVPRQTIERSTVSLVQAPPPRRLDSTRGANFIKREETDQIPPATPTYPLSPSSLSNHEPILPQLPNCHLAGHRLSDCIHASLDGEVWSAPPTVGPFSSPVYRFPHTRAFAKDLRMSQPMRYRMHDYTKELVNLPTDPATSSLVAVMQGDWSDQLWWSPGAEERAAETAAFGSDGVVQMEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8I1</accession>
    <name>A0AAE0U8I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_517536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8I1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23915" checksum="50EE0443C4880948" modified="2024-05-29" version="1">MSGGDSSGVIVDYSTASRLKKDVFQTLTLPQCLAEKHERPLYQITCGDMGTEPGVLEYQLQTGFLRAANWGAILLLEDVDMFFPELGFKDLKCNQLASIFLYHLGRSETLVLLTVRYVGQNLMGREPRIHLPLRLPDLSLVDQKRIWCSLIRGLRQFSLSESDENLLIKFIKDGLDAEREELEMMNGRQIQRAHDSNATLEWEGQGADVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8R5</accession>
    <name>A0AAE0U8R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_533819</name>
        <name evidence="1" type="ORF">B0H63DRAFT_542634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000030">
        <property type="protein sequence ID" value="KAK3365379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8R5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3365379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="18597" checksum="88DFAB0964F8A50B" modified="2024-05-29" version="1" fragment="single">VQIVALEEFLDTPSRVGEHEQIPADIQISKQGDELHVVDHANRSRLQVSFARTLRVPETEAPYPMPPLFGPFPLVSVGQLLYHTTPSLEKGGLLIPMFQREAMAMRFSGTTNKQGLYDWQPSREVSKPEFGVMVLPGSVNAVSGIPASLDRGNDELGVIDVSKFSRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U963</accession>
    <name>A0AAE0U963_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_518193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U963"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="75" mass="8938" checksum="FF01975737A7D603" modified="2024-05-29" version="1">MPDVFATLKHNLKDLHFVPMSRRRVVDGCIYRVHGWPDLERYRREDCLKAIYKTLRENFPGEEYEEDVELLGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXU1</accession>
    <name>A0AAE0JXU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_515835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000016">
        <property type="protein sequence ID" value="KAK3366333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3366333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="505" mass="56487" checksum="C46EF953CB706989" modified="2024-05-29" version="1">MDVTPLPSSPTMARRWARKLERTCCTCASYFPLVFVYGLTSWAVFVLVTLSSESTKVTWLGPSTAIVGTALYLLLNWSYTTAVFTSPGSTTNNNGYSTLPTQAPPQATSFTKCQARKPDRAHHCSTCGRCVLKMDHHCPWLATCIGLRNHKAFLLFLTYTTLFSLFAFICSGAWVWLEIMSNTTYVETLMPVNYIMLCVVAGIIAIVVGAFTAWHIYLASRGQTTIECLEKTRYLSPLRRTMQNAFNAQHTAGQGVALPKYGQQLLDIHRNVLPGITRPEEGEDMQRQSPGSSAPSWQYDENASQTTLLGPEYQAGSRRYTYDEMERMRARKRYEEYLDEQDSTKLPNAFDLGPRRNLLHLFGPSPWLWAFPICNTTGDGWSWEPNPKCTRAAQAYRPARLSSAPPIARRRTPSKADRILGRDPNMYEDDPFVSPGEQEAVSMRRLSPTGRALDNSGGDDLDDDDDDDVDDEAGDDYRPDVSAGVSGSRAEAERRAMNVVTNDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K145</accession>
    <name>A0AAE0K145_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_535641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K145"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="323" mass="36369" checksum="98B4FED3C7E32F7C" modified="2024-05-29" version="1">MTSTVMRLLGAKVVAPPLEPRSTLSAQNHIYEATESPTTPIYIDAENAIQIHQPGESQVHLRPSPSSHTQNIEDDANQMKSYPFSRAFYMKLAPYHVLGRVTIFMYSALLQVFTSMYWNAPFIISVQIFDHLYKSPKHSPDINAFVLFGLFTSCLSVIITLQSMFAMVVVITAKWILLGRRELGNYSWDESSYCQRWQVYLAIEGLRRHCFRGGGILGMLTGTHCLIFTEPDLLTLGDRVAVDDASLVGHINTIGKFDLNYLIVGDRCVLRSGTKAVTSWDQKVLLPHFQNESTSETNQTLVVNPDVCPVEQRMKKLKIAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2K5</accession>
    <name>A0AAE0K2K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin-like protein psy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_488445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2K5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3368425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="35768" checksum="2187A62FABA5E03E" modified="2024-05-29" version="1">MSYGNNEYAGHGYSGAPEPQTTVSYYSSPYVPQQGDQHEMQPFVQGQDSNVLSINDFLNRVRETRDEIRSLRNDAEQLAALHNRTLAVTSSLANSPEQQALDQLSATTKHKSNALRAQIRDLRADTEQTADQGSFKLKKSHVESLSNEFRDELRFVIAEDQRYKDLCREQISRQYRIANPDANEDEVRAAANQDWGNEGVFQAALRSERSAQADGVLRNIRSRHAELKHIEQSIVELLGLFQDLDTLIVQQGQLITNVASQADRAQDDLEKANGEINNAVKISLSTRRKKWWCVLIVVLIVLIIALAVGLAVGLKKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4N7</accession>
    <name>A0AAE0K4N7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_305131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4N7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="213" mass="23329" checksum="503810BE74DF8E6F" modified="2024-05-29" version="1">MFHTLVRLVCRFSRGEDGGEHDEALGGTLGGLGSYGTSPAPQPEGRKKWNSGVKHGEASTCSYPAQAVELPSIALVSSGLLSAQLPSCLRSEQQKRTRPRVAVHTYPRRRGSSRDKASGRPENAQPRERQTCRLLGAKRNLPVVGRRQLRACSGPSSRPHESAEHRSNEQSLCNCRSSCEWARCRAPSRQTALAACLEFLSRGIDAPDWIQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K523</accession>
    <name>A0AAE0K523_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_312510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K523"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="28087" checksum="E076B6BDE3894C46" modified="2024-05-29" version="1">MDVNSLFSVKGKVVLVTGGAKGLGRMISEGFVRNGAKVYISSRDGKACSQAAAELNQLPGSGCGSAVALPADLSVEKECRRVAHELTSTHGETKLHVLVNNSGANWGAAYGEYPDSAWSKVLTLNLQRVFTLTQALTPLLEAAGKSSPNNTDPGRIINIGSIDGIRVPVLSTYAYSASKAGLHHLSKALAQELGPRGITSNTLACGPFPSKMMAATLRDFGDEIKEANPLGRIGTPEDAAGACLFLASRAGAYVNGATLTLDGGVVLSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5V1</accession>
    <name>A0AAE0K5V1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_318596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5V1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="60003" checksum="FDF53E73F4595308" modified="2024-05-29" version="1">MEVPDAVNSPFSALPASWILGAAVVVTFAYCAICLVKRVAGTPGNPPLPPGPPGEFLLGHYRVVPLDAPFRKYAEWAKEYNTDVLYFETLGTKWIVLNTLKSAVELLEYRGSNYADRPRFVMFEEMGWSPTLTWLRWGPKYRLHRRILQPPFTKSRVAEYAAIQQREALICCKGIIDNPVVWVSSVRQFAVAIMLHISYGLDVDGPTSPWVKLAEDSANAIGKSGAPASSIMDRVPATRYLPSWLPFMERLRYAHTWRFAIESITNLPFEASLKQMASKPDRKFFTHNRIAVFNENAENGIPNEFRLEDIKGAAATILIAGNDTTAATTMLLVLYLMQNPRVQQKARAEIDHIVGPSRLPTLDDIPNLPYTNLVLQETYRMNPLSPLGIPHASVADDIYDGMFIPRGTIVYQNVWAMLHDESVYRDPFRFWPERYLPVAEGGNGEPLPVGNFGFGRRICIGRNLAESSLLIVLATMLATLNINWPPGPDGKPTPFEPEWSFRGQAIVLPFKAAIASRSKKAEEILDSGIRELRDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6H3</accession>
    <name>A0AAE0K6H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_402445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6H3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="508"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3370507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="909" mass="100658" checksum="6FDAF95C415D4D66" modified="2024-05-29" version="1">MAHALQHEQETEQPPKRPSLVGTVVLGGIEDLVQPLGSEADLQAYKDSLRETQCSKCGTDIKIDGASIVSRTKTALKQDVGTLHPWIRCPRCKYLSCVSCDASGRTNPARLRYQFRGKRSLLTWCCDEGRLFLIWSLLCGTEFRKQPNNEIPNTAVTDRLRPRKSKADLPSPTKPATPEKATEKRPTKPHKPPRPKESQLSKGVGYGGPLGPTHSLPGSKNKGQGLSKAAIKYDEALEQYFSALSLVLPGNPTRDGAGNPTQDGGKQLDFDLHRQPVVSALIPRSPLLLKACEVLRNDSVEEIGLHMDLVAAILDFLEAMNRHPDTIPFLYRAQILFPQAQQLIYYTFSPTETQTTGSTMSQETVQPVNAVLRRLTIPCQFYSQAALKIDDLGTPEDQQLIALTVRICAVAEEQEKNRLTHGSDQQQSELGDTSAKPLPDAPAKTRLQSRNAKISQETNRTDLDHVQKKASDFHREYCVAEVEDEKIFESFYFAEKARSISKESSAKGRMKKLVTQVTSLQTDLPEGIFVRHGASRLDVMKVLIVGPSDTPYEHGLFEFDLFCTNDFPRKAPEMQFRTTGGGRVGFNPNLYAVGKVCFSLLGTWSGQAWDPEHSTLLQLLVSIQAMIFNDQPWYNEPGRENRIDDKASGDYNMEIQRMTIQHAMTYWLKDRLGQPNKGKAPAVAQKPSLTADNKKGNPSSLHPLPVPPHVPSKKPPSLLPVPPSIPKGVSLPYSVFKSGQHWANSPALKAAMQSSKSAHPSKLSQVSQVSEGSQPSHVSQPSQSPQTPQAPQISSESAMTFFGAHPLLTTHFSAIMCLCPETPPVLHLRPPSRRSLSSTRIFSPAPFPYPPANDDYIWGKIIRNHFGLKADMIMATVKKWQRTANWGVSPTGSKLISELEESFRTHGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K892</accession>
    <name>A0AAE0K892_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_563448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K892"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3371933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="80" mass="8880" checksum="C3AE4CA422150050" modified="2024-05-29" version="1">MMSAVSAAIDAANEAEQADWYKHGCKPGTYACAKNPKTGGAGWKVCNTSKQWVYAGDCPWKSYCYFNKTNGSPYCIPWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K913</accession>
    <name>A0AAE0K913_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_484558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K913"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042031178" evidence="9">
        <location>
            <begin position="16"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="189"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3372393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="57614" checksum="D6650B300B962B6D" modified="2024-05-29" version="1">MRGLIALSLVACASAAPKFSHETIHGEAAPILSSSNAEVVPNSYIIKFKKHVSEASASDHHVWIQKIHSSREGEHRDLKKRGLVDDVFRGIKHTYKIGQGFLGYSGHFDEETIEQVRMHPDVEYIERDTIVHTMRIVEEKPKEEKCEGETEKSAPWGLARVSHRDSLKFATFNKYLFAAEGGEGVDAYVIDTGTNIEHVDFEGRAKWGKTIPQGDADIDGNGHGTHCSGTIAGKKYGVAKKANVYAVKVLRSNGSGTMADVVAGVEWAAKSHIEKVKAAKDGKKKGFKGSVANMSLGGGKTRALDDTVNAAVTVGIHFAVAAGNDNADACNYSPAAAEKAVTVGASAIDDTRAYFSNYGKCTDIFAPGLSILSTWIGSKYATNTISGTSMASPHIAGLLAYYLSLQPAEDSEYALAAITPAKLKENLLKIATSDVLTDIPKDTPNLLAWNGGGCSNYSAIVEAGGYKAKKTDKADKLSITTKVSELEKAIEHDFQVVSGEVVKGVSSFSDKAEKLSEKVHDLIDEELKEFFKEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K997</accession>
    <name>A0AAE0K997_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endothelin-converting enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_291212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K997"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="103"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="565"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="84888" checksum="F5751B29164E689C" modified="2024-05-29" version="1">MASASEKTGLFGAHPPQELPSAPHARAHVHVPDRSQCRRRFLRGAIILFGGLAILNACFRSTSAPNNPAPKPTEIDVCLTPACIHASSEILYNLAPNFKDLDPCTDFEELVCGGWRERHDLRPDQGDAFTGTIMSENSQLLLRHILEAPYPKSSEHSYFSPMQLGASSHSADEENFEKLTSAYKACLDEPTIKKLGISPLAKIVAQIKLSFPLSRTSSALSSNVLSDTILLLSDYGLSGLVASGTGPDDADPDVVVVSVSPPWSIGLPSKERYEDGALVEKYRGVVVEVLSQLSPEENKDVLAAVVDLEKKLAAASPSTEERQDVTKYYNPMSLQDASALAPQINLSHIISTLSSGNKVDRLIVASPKYLQELEKIINGTDAAVLQSYFVWKAVQAFYSYVDSPVVTPYKGFVNELAGKDPNSAPERWRTCVNHVDDGLGWILSRFFVEKAFSAEAKDFGDLIVSDIKDEFVKKLKATEWMDDETTSKAIEKVHNIVQKIGYPTKSPNIMDPDNLASYYQTLNISAETYFSNALSANAFAVAEEWSTLGKPVDRDQWGMTVPTVNAYYNPPGNEIVFPAGIMQFPVFDVQVPAYVSYGAFGSVAGHELSHAFDSTGRHYDQNGNYTDWWTNGTVKAFEKRAECFVEQYANYTVPGSDDKPLHVNGRLTLGENIADAGGLSASFQAWQRRAAEKPNLHLPGLESFSQDQLFFVAYSNWWCGKSRPDTAINRIYTDPHAPKWARILGTMANSREFRESFQCESKKPTCELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9A5</accession>
    <name>A0AAE0K9A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S5 domain 2-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_296292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9A5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="15692" checksum="C5070E287D8C43FF" modified="2024-05-29" version="1">MASQAVQVFGKKKNATAVARCVQGHGLIKVNGVPLKLFGTEILRAKLYEPILLLGVDKFASVDIRVRVTGGGHVSQVYATRQAISKAIIAYYAKYVDEHSKNLLKSALIQFDRSLLVADPRRCEPKKFGGKGARSRFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9K2</accession>
    <name>A0AAE0K9K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9K2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="240" mass="26356" checksum="7C7674D4FEC7A77E" modified="2024-05-29" version="1">MFDLEDGTEWFARSDPTGAGFQAIARHTLMQVALRIGQSAGRLEYAPCINQQRATWMRDQKGARVQLVRAFRRPGPEEQRREEPKWGSGRHANPCRKANVPKSWLEVEKAMRRRRHGSVHDPLPRPRDDIIARPYHGIGATGESQQQPFPPNWMSACPRGQDTGHKKDVNVNVDVKVDVDVVVAVVVAVAVVVDMDVCACEGVAECHLARSQAHAPAPARAVVARCDTSLGGPSPNAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9P0</accession>
    <name>A0AAE0K9P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9P0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="63619" checksum="3467EA10840DBF55" modified="2024-05-29" version="1">MADQGMNLGSDSSPEAAAFPPLDSEGKEPGQGDEPEPSGLARGLNPEVPAFTAQEGQDYQPTDTQGDYMPSYHNYGVEQTQYLPSQQYRTLGYHPSLPPRPPVAAYLGQAFSGAMQHYHPAQYLHPAPPPPPHYPPQYQYPGAQGTNFGPAAGGFISGAGPSTSSAPVASLAGSGYGAKRRHDSISRSTHNASSQPDEESASGNLLGDAPVPTEGPGGLPLFQPMRMVAKWSSSGGAGRELSSYEKKQRLDLGISQNYMGDPTAASNQSANIPDWESCSFYMTNLPPNINAHLLFKAFRNVGRIFSLHINGPNEIHKTAAGKLVLFSAADAREFFRRYRHHHGTDHLVIQGLKPAVVRDRIKVKESDFPPTHSRVIIISGPPSVVNYDWLLEYFQKRFYFYIDEVIHLVVGQVYNSIEWHFGSYYCQASAAFQAINKELHHLGVMVKYARDPCDHSLPSPPCGTFSGRPLSPAFDPTNPWATMHGGKSPAEGLGSPQPADEKSPSPVPEIAQGPLEEGEEREEATALGSYKANINYAGQDGHGGFGLLHKGRPKYGGGGAGRIYGRTYGGGDVENWEEESEDDGHSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAJ7</accession>
    <name>A0AAE0KAJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_297484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAJ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="14">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3372455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="223" mass="24171" checksum="C23E3A2BB6148B5D" modified="2024-05-29" version="1">MSNLASPPSSATYYDILGLSLSAIAAVAEEDDPKPIIKRGYRRALLHHHPDKNNNKSSSLSNLPKHSSHNNNSSSSSSTATTTFTVDQISSAYAVLSSSKLRAEYDAALRLSASSSILPSVEALSTRFQTGIENVDLDDLECDEYSSQDEKGGRWYRSCRCGNPRGYQFGEADLEEVADLGELMVGCADCSLWMRVHFAVVHDDSDEARSGDHIGGSTATEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KCZ2</accession>
    <name>A0AAE0KCZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BCS1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_253044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KCZ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="57"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="292"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="553"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3374558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="699" mass="78682" checksum="B31D62C13CDEF831" modified="2024-05-29" version="1">MNNLLAIASTTSLFGNSTTPLQEQFEQRIPGFGVLQGFFKKWLKLELTTVLTIAALMGAASSGVQSLQATGSKLYWWIVRFLTASISIAGNDRLNREVLNWLGSQVLGKEGNTRILTAHSETIQNDAWYYRRVAQERNDYHHEKRMPVEYLPTFGTTWFVHERNIFMVRRILTSSSRYHSSFSKGTPDEYAGAPEGNEPLVVMCLGRSVQPIKRFLNMCRDFSDKQREAFVTVRTSKRRHYEESWDTTILRPLRPLETVHFDEKIKAELVADIINYLDSNTRKFYNGRGIPYRRGYLLHGPPGTGKTSLSLALAGVFGLELYLLHIPSVREDENLEKLFTALPPRCIVLLEDIDAVGIKRRPAKKSDDTDDENDDDDDIEEDNDRSPRSRCTLSGLLNVLDGVASQEGRIVLMTSNFAEKLDKALVRPGRVDRMIYLGNISKRSAELMFLRMYNRDGDGPATAEKTVQMSEEELKVLAVEFSAQIPDNVFTPAQLQGYLLNHRDSPVEATKQMAAWAKEEQTLMEEAKERARKAAEHRRKKKKELRLKMLAKAAKEAKKEDTDADDEKETKALMEKIEKEEAEKKLKKDDSEKIQKETSGDVKSSVDVSDKEKAEDDKKLSNGDAVTEGEALTNGTTTAAEESDKSGNAETESTVAEPAEEDKTNSTIVVESPDTKTAESTENKTEKEVVDSAAEAKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDI4</accession>
    <name>A0AAE0KDI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_549013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDI4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041897746" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="490" mass="52392" checksum="0B2268DF18268978" modified="2024-05-29" version="1">MTRFSTSGLLLGAIPLVLRGVEATVVPNPVVTICRQIRDQISSVSDVIFPVQALSFISGTDHWFDTSNEVPTCLLQVGSPADLSTALQIVGSTRTPFAIMSGGHASNPGFSSTTGVHISIKRMDQVVLSQDKSTVEIGFGGTWADAFVALEGTGYNAVGGRVPGPGVGGFTLGGGFSWKTNQFGLTCDTVKRYNLVLPNGTITYASQTNNPDLFFALKGGMNRYGVVTSAVFATHVQPPKVWGGLRIYPGSSVNAVLAATAQFYAQNTDPKAVIISTIEAGATGTTALVLFFYDGPEKPAIFNLFDNVTSLLSLTQQQNFSALVKSFPAGLSEPRNVRGAFHTFSTSSLTPRFLAAIKNETDSISQVFSLHGGTEAGYDIEPFVPFGQYATDSAYPHANSPLPLNLYFAWAPSSQDEWWYARIRQSVATLKQVAIEEGIYSSSLASYPNYAITGTPVNEMYGSANAARLRQIRDQVDPTRIMDLAGGFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE60</accession>
    <name>A0AAE0KE60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein RBG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_482016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE60"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="367" mass="40538" checksum="7B56D6D7D813BD07" modified="2024-05-29" version="1">MSTTVEKIKEIETEMARTQKNKATSFHLGMLKAKLAKLKRELLTPSSSSGGGGTGFDVARTGVASIGFIGFPSVGKSTLMSKLTGQHSEAAAYEFTTLTSVPGQVVYNGAPLQMIDLPGIIEGAKDGRGRGRQVIAVAKTCHLIFIVLDVNKPLTDKRVIEAELEGFGIRINKQPPNITFKKKEKGGLNITNTVPLTHIDPDEIRAVMHEYKINSADIAIRCDATIDDLIDVLEAKSRSYIPVIYVLNKIDSISIEELDLLYRIPNSVPISSEHGWNMDELMEAMWDSLNLVRVYTKPKGKLPDYETPVVLRSTKCTVEDFCNAIHRTIVEHFKVAIVYGKSVKHQPQRVGLSHELADEDIVTIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEM2</accession>
    <name>A0AAE0KEM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_256108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEM2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3374770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="567" mass="64153" checksum="5BD4AD53EEA71162" modified="2024-05-29" version="1">MPSTEPIHLCAGAVALGVISHLGIFIRGEWHMQAPALVTVFSLLALVIFFAEHYYLGADIASSLKTTSLVASSYAAGLFTSIAIYRRCFHRLRHFPGPWAAGVTKFWHVWQCRTGQNHLVMEELRKKYGPIIRTGPEELTIIDPVVPPTVDGPGSTCTKAVWYDFLLPEIALNTTRSKPAHDARRRIWDRGFSTKALAVYQERVVEYAETLATRIEELDREDKPVNVSDWFYWFTFDVMGEFAFARSFGMLRDEKWHSAVKLLRKAMSLLGPFSPVPWLAQIAFYITPWMYIVKDWLSMMQWCKQRMGERINMKVSKPDVSHWLIDASIKKGSLEADREWLNGDAVTIIIAGSDTIAPTLVFAFYELARNPSHQTTLLSELHGLDIYNPTHLLRCTHLNALINETLRLHPPVPTGGYRQSPPSGLTIPISGDGVFIPGNTTIISPRYSLARLESSYQNADQFIPERWTTHPEMVKDARGFAPFSQGRFNCVGKALAMNEMRFVIALLVTKFEIAFWDNDGDGDKGERLFKDLRDQFTAAPGRLDLRFKKRTTTTTTTTMTVQSGEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF11</accession>
    <name>A0AAE0KF11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_275190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF11"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="653" mass="73284" checksum="371C7E9231A102BB" modified="2024-05-29" version="1">MDASSPTSSSAKTPHNKGPRACATCARAKSRCIAGPDGAAGNCERCHRLKKPCSSQTPAPPRKRKEPKPTRVAELERRLEDLSARIESAQSQPLTPPDTETTIPGSRTSQPKARLQPPNARTWQTFQHLFPFPEPDDISSASPNPPSSENNNSLEVATETLVPVLVAPRARPNPPPPQHKAYQQTLWPEGDEAEALLAEHTTHLAHLTPFAVVPPHLTSLQFRQLRPFFWKAVMMEAYHLDGARQVALGNELLREITEAAFVNSQKDLDLLHGIQVLVAWYHYNLKSNQITNLLFLARSICASLGIGEPQGAAKMATDYSSLETMRAFAGTYYLVTVSFTTNHKPDALMNTTPYLLTCCQVLESRMEYPTDEILVWLVRQEQLSQSISQTVAYRGSNFRDGDLPLAIVIKSFQQQLQSFKSLLPPHIAENPSLIGHMYAAEILLYEISLKDMPGVSDMERLELLWLCVHSTNAFLTNRFAEEVHEHPRFICMSSFDFIYAFITALKLITLKTPGWDLPRVRQALCFDHFVERQVKDMMFMAEKRRRRRIRASGDVEPSAAEERAAEEEDPFLKLAKKMRGLASTMRSELEAEFGTGDICAHVATNQMPMTMADATADIHDLMQDIETSLWQDISGTTGIEFDSMFYSNLFFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFF5</accession>
    <name>A0AAE0KFF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_270040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFF5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="36"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="761" mass="83424" checksum="DED92B1640B6258B" modified="2024-05-29" version="1">MTMRSYTEARSRWTETVKHGPGIVDLRRAVKFSAGPCQSGCRSVCWKAFLQFQDAPVDQWSILLRESRASYISLCEQHLNFIRHPERLAELSFDPLADSPDSPWNSVREDKGIRAEILQDVQRLPDEPFYHQETVQTMILDILFLYCKLHPDVGGYRQGMHELLAPIVYIVAQDAVQVGAASADETADTTMLEMLDSSFVEHDAYALFAKVMGRASAFYEVGTETKPAPSDKNTIVEKSKYIHEVALMRIDEELANHLRNIEVLPQIFLIRWIRLLFSREFPFEQLLVLWDTIFAFDPDLDLVDLACVAMLLRIRWTLLEADYSVALQLLLKYPAPQPPHGPHTFVEDAIYLRDHFNAAGGATLISKYTGRSPISSSTNSRPSTPATSSFQGFGSLRQRTLSARSPLSAPVRLLQQPGGVEALFQGAAKGVIERGEKLGINQAVRDAMGEIRRNVQGIQDGRVSSRASRASLGEIRPVPSDHLPAVRLVERRNRQLTTMLDESIATLKLLAASGFEGEKEKHIEAVELTAAKIQFVKACLEDTSLSLPDEEPPSVAALTISARSELKLPSVALDTTPVIMTSSAADAARSALSSPVSGEETNGLTTPPIEENPQAEQAAEEADKMDTDVLENSITSFTPESSLTNAPPLVSSPVSPPNAPPPERPKGPIPTRSTLAQSSFSWMLEPDTTVASLPHASSSPASRPISGGGSGTQKKRHNANASRERNAFLFGEVVSGGPGERKLSSEEIFGLEPLRKGASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KIT4</accession>
    <name>A0AAE0KIT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_384064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KIT4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="122" mass="14324" checksum="EE0AEBF12876682E" modified="2024-05-29" version="1" fragment="single">PHHRHQSSLEGIVYLSSEAPLEPGQRNQARRKFYDIISYFEATEPRSDEFSGHYNRPLLVRLTYEYSRSEKSQDIFLRAFFQSVALPIDGEDDVDLDDTELEAALVRFAEHLFDNFFLPRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ51</accession>
    <name>A0AAE0KJ51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_224015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972869" description="GPI-anchored cell wall organization protein Ecm33" evidence="7">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="41907" checksum="7B3939E761AE8EA6" modified="2024-05-29" version="1">MLAKILLPTLVAIGSVSAQSGVCTFTSTQTYHSQAEATALANCKSVKGSIVIASDAQPNIDITGPSEITGDLSLLSNNLIETFKSDNLAKIGGNFEIRNVTKLGALRFPKLTEVSALEWFTLNNLDTLEMALSKAVNITISDTFLQKLDGIDVTSINKFDINNNRRLTKFSTKLGNVSDTLTISSNGLLLQVDLPNLIWIKDMQIANVTKFSAPSLATVNNSAKFDFNYFTEFLAPNLTSSGVVSFIGNPSLTNLSFPLLQTVSRDLSIANNTALKKITGFPELEQVSGAVLLRGTFDEADFPAIQDVKGAFDVASSANITASCDKFKPLAPANQGGNGLIQGVFSCEGLKAEATDDTGSGGSGSGSNTGGGKKDSGAAGLAVNTVLFGVAALGVAQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJA7</accession>
    <name>A0AAE0KJA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_524842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJA7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042257420" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21151" checksum="BD913F41E5BDEFBF" modified="2024-05-29" version="1">MSSTLALATGMVLPQLVGAKAASERASVAWINPCIFLPHKPIEPITITWTMGSSDNDCLYQPPVDTSEMSITERGLTCKYLDIVSTSEGGDCRRRSSKWGLSYNTTSPGSEDISGSAVSAWSNGPKKSEISVTGSTSSPGTSICEGEYLCENRRMEWKRSRHGQVWIIFRPFAARPRYTNPPQTEPNILDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJH2</accession>
    <name>A0AAE0KJH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_502320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJH2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="79707" checksum="7BB943A9DFE1F4E7" modified="2024-05-29" version="1">MNHQFSHLLDASAYDTDGLCGGLLIRVHKHAELATAGALRAQRDWKELIGPLTSNFCGSLAPISLTAVAAPGCRPERLEIVSYVIELGFLCDDLMDNAQDTASRLAMHVTTLMDEMKNGVESGLAILDGPAAAAAGSFSSSTISPEQRRLAINFVQGLMAVDVPASMALFGRMMRHIPDITNNHTRTEFGDLDEYLEFRVINFATRLIIAALIFGMGLTISAEEEEICLELSRPAWQAAILVNDIQSWEVEYSVALEQKVPLTNAIWVLMKQHSLSLDEAKELCREKSKTLVAEYMSILGVASGRDDLSKDARALLESLQYMITGNVVWGFQSPRYDPRVERALPNEFAPQKVTNGEENDVNGVNDHHKDVETLPADCGTDTVEVGNGIISLDVPQLDTQVVDAPCQYLDSLPSKGVRDRAVDALNVWFDVSPEDIVVIKRVISLVHGGSLMLDDIQDGSKLRRGKPSTHEVFGEAQTFNSAGHRLVQAFYEIRQLGKEMQHLVVGQSYDLSWTCNMECPTEEEYLSMVDGKTASLFRMLARLMDAKSHAPSKPDLTSLTQLMTLLGRYFQIRDDYMNLTSADKGFCEDLDEGKYSLPLIHALNQKTKDITYKEHTTNGKATNRNSGTAAAGCKEGTEKRKALLILRNILTRRRLDGKMSLEQKHLVLEQLRESGSMEYTLAALRKLFGEIQERARQLGTRRNEPLEALMSLLKVSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL48</accession>
    <name>A0AAE0KL48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_480006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL48"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="122" mass="14145" checksum="0BCB4C98CDD666BB" modified="2024-05-29" version="1">MPMPFFHTLIRTHHITSRKKVAHLRKAADQLSCYALLRTGGSPGLMYCKGSEEAVREWVSTVQRLRYMDFRLLQRPVVIETMTTQPDEKSGLVEVETVKEFAAAMEQRKLTSWWKTAMEWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MZM1</accession>
    <name>A0AAE0MZM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_405593</name>
        <name evidence="2" type="ORF">B0H63DRAFT_405598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000019">
        <property type="protein sequence ID" value="KAK3365449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000018">
        <property type="protein sequence ID" value="KAK3365456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MZM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3365456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="74" mass="8462" checksum="081AB8D8C4F82227" modified="2024-05-29" version="1">MCLQMDYLFTCGHRGFAKFDNCANFGLTCYGAGGNHQDLLVQDVCNDCKRRVYDPNPNGRSNDPYRKKQSRHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2U1</accession>
    <name>A0AAE0N2U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_71267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2U1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="620" mass="65032" checksum="45AF2B2E90494B8D" modified="2024-05-29" version="1">MPPKKKQGTTLSLGEFLGGDSLGKGGSWADEVEENYGTQPLPAADRGRYGGGGGGQSSAYTTSNNQGYSSIRDNLPQELPTKPPYTAHLGNLSYDATSESVTDFFSGCKVVNVRIIEDREQNRPKGFAYAEFEDLEGLKEALTRDGVQFEGRSIRVKIADPPKERYGGGGESNRDFSDWSRKGPLPDLPGRSGGDRGGDRGGFGGDRGGDRRGPSDFGERRAPREFQQGSDDGKVRDFSTWERRGPLSPLPQAERRPESRDGSRPRTNDGTRGEFRGPRGASPAAWGPGEGRQGTSTSRPPRREIVDRPERAATAAEKDSQWRNNMRPDLAKSPGESREGSEAPPSPAGTHATLAGGARPKLNLAKRTVTESPAVTSPALSATESKDSKASPFGAARPIDTAAREREIEEKRIQALKEKKEADEKAKEEKRLAKEAALKEAAAKEAAAKDAEVEEAAAKEAAATETAAQEAAAKVATDKAATEAPAAEATAAEPAAEAKPAPQEGSEQKAPVRREPAAKAPPSRAETAGNWRTASGGAPTRGAHVPSGVRGGRGGSVPRGPRNDAGRPPRANGSGPAPAAQPQAPAAAATSGEKSPSAATPDDDGWTTVAPVAKGRRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4V1</accession>
    <name>A0AAE0N4V1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4V1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="745" mass="79999" checksum="0A1D4FAEBA032A52" modified="2024-05-29" version="1">MSRLSLSEVTDVQLKDVRPLTMNVGGEDIALPDRFVFDMEPVNLNRTSSSSSTGMPMGQLKHAKSRDNYLSRESLDILYDSDLPGEFRLRMLFGQRNSGQDDLSNHRAKVYRESEVSRRSSNDSGIGSMTYSGLASMTSFGNNSMNKHTVPTHDEEERYQRMLGRLRKAENPEDSSQPPGKPTPNITAPKPPTLNTAHMIKEKDMWPLGSEGYSHATVIRRHPLSASAPSPRTKLERSSDSGYASGSSSVPADSYQQMGDSSCSSVGSSAKRKHSSNESGGSLSVIEEKPALESPSKKLNPAAAEFKSTLGPVLMPVLSHKRISRIPITNLFPAAPGGLMTGILCTPQEPLTGPRGSTGPRPIHDTAEGADAFSLSYISPNTVETAWPYALPGHTPAAMVPGTFPASMMTNDTNDTTQVSNRPHSSVQQGQDGIHNLDGYNTFPSPGLAMTNPASLSAHQSSTSGANAILPPPGFHRGNSAPTTLSETAFPLSLAIGNMADTSRAYNTLPCAANAKMFSPGTIMSSMVPPPPGIPPGFNLGTTACNPDTPAFYPPSSATLAPSLTFPPPVQPLFGPDGKLNRPNFPVTTKPRDHDPIKQQQYEAYLEWRKANEPGYHVSCKMRQANRVVRKYHQQQQQQGAGSTGQGNKTVQQSETPTSWKAIIEKAKAAVGAAAAAARAERKCAQDSVKEELRVKVRERSETEASSGDVFGEKVAIAARLPEKLPTAARKIERSSAAGKENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5R6</accession>
    <name>A0AAE0N5R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_454624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5R6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041919273" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3370454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="146" mass="15432" checksum="3C0FEE143119A0A5" modified="2024-05-29" version="1">MVKFLSAVLALVSAVAVSAAAIPGDAVEVIRSAEVEVVDKRATCAYTCGTICYYSTTVTAAKNKGHQLRTSGSTINGYPHQYNNYEGFSFPTSAPWYEFPIMNTFTVYTGGSPGPDRVIFDASGNLDSVITHTGASGNNFVACKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7K1</accession>
    <name>A0AAE0N7K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_293155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7K1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="249"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="492" mass="56982" checksum="6053DAF1701DB6C2" modified="2024-05-29" version="1">MSDDDFMQASDEEYDFEYEDEEEDDSGNVDIENKYYNAKQTKTTDPEEAVDEFLGIPALEEEKGEWGFKGLKQAIKLEFKLKRFQKAIEHYKELLTYITAVTRNYSEKSIDNMLNFVEKGADSPAAVEFIEQFYSTTLRCFQSTNNERLWLKTNIKLAKLLLDRKDYYAVGKKLRELHRACRREDGSDDPTKGTYSMEIYALEIQMYSETGNNNQLKALYQRALKVRSAVPHPKIQGIIRECGGKMHMSEENWKSSQSDFFESFRNYDEAGDLRRIQVLKYLLLTTMLMKSDINPFDSQETKPYKNDPRIAAMTDLVDAYQRDDIYKYEDVLHKNTDLLADPFIAENIDEVTRNMRTKAVLKLIAPYTRMRLDWIAEHLRIDEPEVQDILSYLIVDGRVQGRIDEHNSTLEIESRADANRIKAIQVLTDSVGDLFKTVFKDSDGFRPVAPESSYSDQGEAGGFDTLRGGSRASRRLRHRGNNNNNFLNVAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8F5</accession>
    <name>A0AAE0N8F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_400999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8F5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37823" checksum="0A034CEC0B7FD204" modified="2024-05-29" version="1">MEVAAPVPARRQNANANRANSGNIIDLTGDPSDASDEILILPPNHTHNHNRASNRRSIPPPLSRNPRRQMSLNHRTPSLARSDGSLLGPAAPVIDLTMDDEDSDGPPRPLNLPNQQRHPARAQGRARSGPPPRAPPRSAAAAHNAQIIGGDPEFGALIGIVRNLGQNFQRFRDFGAIGNFPFFGGQGLEPVGNNARAPFMNNPLGENLPRFNYGANGYNSGGLAKPRHEPPKPAREGFSRATGAELDYVCPSCDEELKYDPDADDANAPPAKKARTRKDREEHHFWAVKECGHVYCRSCYENRKPSAKSPTKTTFRVSPQHPKKLLCAVDDCESDVTTKAAWVGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N957</accession>
    <name>A0AAE0N957_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GPI ethanolamine phosphate transferase 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_482774</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N957"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3375387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118248" checksum="A524B6872E3E06B7" modified="2024-05-29" version="1">MVSPPPPPPSKSKKTPSPSSPPDYKAISAQWAAAKRAKILDDEIREQDEERTSVLARQREALEAARKKSYETRWLWTVGVWVWMLCIHVVGIAYFTSGFLLTRLVLEDKSTCNAPPSLNSSSASIDILPVWEGKGTVDGGCWHPRTFDRAVVLVIDALRYDFTVPVEDNAKFHNAFPFMYDTALQSPHNAFLRPFIADPPTSTLQRIKGLTTGTLPTFVDLGSSFSGTAIEEDNLLMQFRDAGKRIVQLGDDTWQSLFPGYFELNMSKPYDSFNVWDLHTVDNGVIEHIFPLMEKKNDWDLLIGHCLGVDHAGHRYGPEHYKMTEKLRQMDTFIRDLAATVDDKTLLVVMGDHGMDGKGDHGGESDDEIEAALWMYSPSPVFGRTKPEFATPPATAKTRPVNQIDLVPTLALLLGIPIPYNNLGRPIEEAFSGIAGNAWDNLAAAVRTTTAGIERYQASYFTARGIAQPSTPGSPADLWSQAEALLASGVGGKKRDWATVYSAFAAYQEENLKRCKSLWASFDIRSMITGIAIMALGVATLLVYISMSSDDDELAVEDSELDRAEKNLQMHGVTAEGDRSASSGLHRRMVSAAIVGAVPVFLGGLLQSLVSGVGDWYRGAGFAALTSIAAVMVTMYDTRESPLLSAVPRTLWGWMAVVFTVSQSVGFASNSYTIWEDSILLFFITTFGFVTALSALRLPNLAERYLSIYHSVLFVLLGRLASFSKLCREEQMPYCTSTYYASATSSTSAPWQLVIPFLVFLILPSIVKAYLTPTRSYEGLAPNWIGYVFRTGLFLSAAYWLLDAANNGNWISGLPENMLKNISVYTAQMVLGLALVAGTTAFVWAPPCVSIVTSALKSGKGAQVVVLGHANAHGARYLLLPLNIMGACFLLSKPMGGGALGVMVWQILSLVEILDLNDLTTTAIGPVMLAVLGSFHFFKTGHQAVLSSIQWDSAFIPLFTLRYPWSPLVVALNTFAGQILATAAIPLVVLWKVNPARKGVLDRVARALGMYVAYFAVESLATMAWAGHLRRHLMLYRVFMPRFMTAAVVLVLVDVVGILVTLAGVRVNTLAISEVFGWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBY6</accession>
    <name>A0AAE0NBY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_245807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="700" mass="74298" checksum="08D679F444C605E1" modified="2024-05-29" version="1">MELSSRVSPTPVQIRNLPAASVFGADSSSPDFPPQYYPSPAQDRARSSATAAFAVATDMAAPSQPNGAASMAAPPNNVSVSPQSAATPKQVAFELIYSEYCARLPLRVSIYPHDTTDSIVTTVRNFYGLYSGKGVSFEDQQGNTLIARYENFRHNMVVNVRVIEEVLPASGAYGPRPFHSPPIGAQSYFSHDGYPLQAPQQYAHQISRPASGTSRVRSPSPNSGRGRRSTSAGTNPNASKKGRSRSSRTRAPGSQAIGDSHGDSVNGYSSGDGAPGSSSGKSKEQLGNTEISLENIVEGGRRKRAKFDSSELPLFAPPQMPAATSNPSVSPARPVEHHRHSLPFVQPGQNPFSNPRPLQSPQSYSNSYAHPGMYATPGVDSRRTRESFSYSHGGSVGPGMSMMPTPDPTVGSCMSEEDKDVAIQLMRLGEMSNMSHGRTSASTLDDTFSGRADAASSTGATSEAESDSEEDVPPARRQKLDTSGNHKKVFQTTESHFAGPQESIETSGDDADYEDGAEEGSMAAPRSKGSKPKPSSVNGTKPRSQSVNKVKTSKPSKPKAKKSTSTSGPMSPASLPASRKPSLTSNATFPLMNGEDDQPDLSTKPRCQRCRKSKKGCDRQRPCGRCRDAGIPAELCISEDEGNGRKGRYGRHMGVPVKTADDLGPPSTLLPSAPIAMAAPQATPSTLAAGALDKNKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH77</accession>
    <name>A0AAE0NH77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_203899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH77"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="389"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3381409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="71052" checksum="C2F26F45CD88BA12" modified="2024-05-29" version="1">MKLTNPGTVPVYTIAGPSNARPLPDWLARRRKRSSKYDAGSQNNFELLQEFEFEEASNCVRVSEDGNWIMSSGTYKPQFHVHSTQELSLSFSRHTKSENTTFLLLSSDYSKSLHLQNDRSLEFHTPMGCHYETRLPRFGRDLAYIRQSTEVLVPAVGLSSDGSGCGEVFRLDLERGQYLRPWQIDVGEDDASSGLQGSINAGSVNVAAVAEATHGLCAFGTSIGTVEFFDPRTKGRVAVLGGQEGEITALDFSQDGLALALGTSTGQISQFDLRNPRPIFKKDQGMGLPIKNLIHMKTPTSERKLLSADKRIIKIWDEQSGDLWTSIEPMVDINFVAHCPDSGMILTANEGKQMHSFFIPNLGLAPRWCHFVDNLVHEMENETAVNETYDNYKFLTVPELKALSLGHLVGKTNLLRPYMHGYFVAAKLYDQARLISNPYIWEEERAKRVREKVEKERASRIRGVKKVKVNQKLADKMIQRQENREKVDIEQGILGDSRFGKLFEDEEFKVDETSWEFRALNPSTKVGGNDDTQAAQRAVHSSDGSSDEGSDAEDTSDKVIMQVSSSRAKGGQAKDTAIGSRAQKQTRATTAKPGEVVGEKHITFVPASKKKGKPEPPSPAEKRSDARRSASSNTFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHB1</accession>
    <name>A0AAE0NHB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble quino protein glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_416274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHB1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042287526" evidence="2">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="39"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="494" mass="51965" checksum="3023620C29DE48E4" modified="2024-05-29" version="1">MLQHIRPVAVATSLLVLLGVGIEAQQPCASVLTPSYAAPVVAAGFSTQLVTQKLFKPRGIIFDKEGALLVVQAKSGITRLTFSDGGGTCLGVTKSTTLVQNSALNHGIEISEDGKTLYASSSNEVFSWAYDSANVSVSNQRTLIRNMTNSDHVTRTLLLSRKVPGMMLVSRGSGENIDMLATNEESGISQIRAFNLTALQDGQVYDYPSQGVRLGWGLRNSVGVAEHPVTGGIYSVENSADQIRRSEVDIHQDNPGEELNFHGYLNGTSGKGDNGNYGYPDCFALWSTKDFPDLGRTIQVGSQFSLNTRGSNVDDAGCANDYIAPRLTFQAHTAPLDIKFNANGSLAYVTFHGSWNRDQPAGYKLSVISFKDGEPTEPSNSTTAVIDILTNPNLSACPNGCFRPVGLALDSQGRIFMSSDSTGEIYVLQQQAGATLPASGTGTGGGGSATSSAAAAGLSVPWRSGDGYTLLVAGLLGVVSFVLGGGSLFAVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHT8</accession>
    <name>A0AAE0NHT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_213610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHT8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042127499" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="748" mass="80893" checksum="598B20D5F8BF68B5" modified="2024-05-29" version="1">MWLLPPRPLLLLVSLVASVLPAGAENVLRSSSLAACQDNSGFTASLFDVVYTPNNNTVAINMIATSSIEGHVLFDIAISAYGYEFIRTTLDPCKSNLPGLCPMTAGDMSNPFILPVADSAASQIPGIAYAFPDLDASVRIYINMTSGEQKGKRIACVEANISNGKTVDLVGVKWGTAAVAGLAIVASAIVSGLGFSNAASHVAANTLSLFGYFQAQAIIGLCGVPLPPVVASWTQDFQWSMGIIKVKFIQDILTWYQRATGGTPSTIFDSLHTVSVQVEKRSLVAPSLAVFGRAAVHHAASIVKRANITTFFGSYIVYGIQRVAFRAGIESTNLFMTGLTFFYIFFVLAAFCVTAFKGLCELAARLHWIKGDTFSDFRNGWLTVLKGVLFRVTLIGFPQMTILCLWELTQNDSPAEMVLAVFFLLGMIAVLGYAAFKVIRMARRSIALHRNPSYVLFSDPQALNKWGFLYVQFRASAYYFIIPVLGYTLVKSMFIALSQSNGTAQAVGLIIVEVAALITASVLRPWMDKSTNSFNIAICAMNFVNAIFLFVFTDVFGLPPLVIGVVGVVLWIANAAFSLILLIMLIVTTAIVLFTNNPDTRYQFMNDDRTSFMKSQTHFQTTNELEALGATARASGKFKPPMDLDDDDDGSEVSNPANMALPPSQTNSARTSMYSNPDHVPAMHAPSVRPRPSSSFRAPSPFMSSRAPSPYTASLSNSSQPNIHPAHPVGHKPSPSAPSAWQRGAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHV0</accession>
    <name>A0AAE0NHV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_451071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHV0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="17444" checksum="507BCDC77E8D4C2A" modified="2024-05-29" version="1">MAATIPRVTKPAMGILRAAALRPVACGGRRFFSATIPRAGIAVTGKPVDDIDVAFDYPSDAQGAYPHADSARPGMPSMAARLDKEKGWPDNSMLYLAVLTMGIGALYMSLKSISNPAEISSSSRERQADPGTDARRSTSYQHHDHPAHKPNNAPMEKWIGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPC0</accession>
    <name>A0AAE0NPC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPC0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="146" mass="17228" checksum="90356A605BDA0E39" modified="2024-05-29" version="1">MDPAHGQVKTGGAAESNDPASIVTSGLFQGMTHEAMNQQVAEIIRFTNLRCNSLLQILDRHNESLDDYYSKYYTDLPAIAPPANLWTHRLRSLQLPLKGDRDARIICGLFFFFFFFFFFFFFFFFFFFFFFYFFFFFCFSQSTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPC5</accession>
    <name>A0AAE0NPC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_522488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPC5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="128" mass="14422" checksum="90A3A54FE07E2C82" modified="2024-05-29" version="1">MPHSVLRHRPVLGNFQSLVLASPVFYQQYLLDRRALLGHALTATLGSLLLDAFAVHTSFSLYKPGRELTKDLIPLFMDNYTAMRTAPPDLVLQQCTEADLADASLEAGSLSVTEQRRLLRALYRFQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPC9</accession>
    <name>A0AAE0NPC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="280" mass="30500" checksum="766B32A28C07DF48" modified="2024-05-29" version="1">MGGLAALLERPPDDGPIIDEFLAEYGSSRYLAYARLTELSTAEVKATKVEKQRRRPRQDGRSSVVRRSEPWTPSALHAFTAVPLQKLTSLGAEADFRDNLLATVGGKTIEVQLMLLLMHALVKMHHELIYKPVVIAGEQLLRQIQINLDRKKELGNIPFRGKGKITCNYRERPPAASQFSVSRLGSSFVTFSAPTIASSARVTVAALPDIFLAVWTSSGSLACLPKAVELMFGLKIRVAPERSECSTTELVSRRRAPLGWGSAPYGTPYEAIGVGVGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPX4</accession>
    <name>A0AAE0NPX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_184089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPX4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="80343" checksum="0A2A60FE4BB48439" modified="2024-05-29" version="1">MTTSTAGGGGAALLVSAATATTISTRASRSKEKAVVITGSSLAAALQSPSGGGIGANDKGHERPRCSQCGRRRTPCHHHSGSGSGGAGAGSSQQSQQQQQPPSHSPSSPSSSSAAITSGSLSAAARPRRISKIKHRTLTAALAAFKNAEPLSSPSSAKKSAAMDPPVLSFYGTEPVPLPSRFAKIKRSLVAGHEKAIEASWARLLDELKGAVEHIESRGPNITPHIEYSDIDDPAKTETFARDLKRYGVGVIRGVVPRADAQAAIDETVKYLETKHDFKAPPPQDPTCFDFFWTPAQVRTRGHPRVLQAQRFAMSLWDNDADDRMAIRFPIAYADRLRIHGANVGGVGPDATGDQGNASGDAGGDTNAEAQRAVLELLGDFASSTVIAQVDNGSLERWEPDGYGRGGTYDAIFKGEWEKYDPWDPTNRVSSTPDLYNGYGACSIFRMYQGVVALSTIEPGLIRLLPSPKLATAYFLLRPFFTPKNKQPERREGPEWDAFLDASNWELESDPSTIIHGAVYGHAQRLTELWHPHLHLRRTLVTIPTLQTGDYIVWHPDLAYHITSSNPNVMASRAPTPPPMSEDDAPSARPVSILVYVPAAPLTQTNALYLARQRKTFLRGHPSPDFDSTGSGLGSEASHAGRPGETEIAEVSGPAGLQSMGLAPFDVAPTPPTDGVNEDGDVEMQGSESSSARPAVPPITRAEAEVARLANIILFPDRYDFYMAKRNGTKRARTRSDVQEEDIKEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPY9</accession>
    <name>A0AAE0NPY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_395338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="546" mass="58562" checksum="4CCF34001BDD36D3" modified="2024-05-29" version="1">MSDLEFGEKSSTAPESSSGQISDGTLYPDTLHKQPTHQSAARVGENDDLDRTHTTASSYTASSLSLGREFVFVAVVCCAQLTTQAGLGQSLSIIHVIGRNYGLTRPEDLTWFIAAYSLTVGTFILISGRLGDLYSHKKMLVIGYLWFGLWSIVAGLAVYSNVIMFDIARALQGIGPSILLPNGLAILGSTYPPGPRKHMVFSIFGAMAPIGAAIGAVFAALFSLKWWPWAFLSFGLVLCFLAGLAHLAVPSPPVRQSQVTSFQSALNHIDLPGAAVGITALLLINVAWNQAPIVGWHEPHVYVLFIIGLLLIPVFFYVELRVAAFPLLPLDALKSADIGFVLGCLACGWGCFGVWFYYLWQFHLVLRDASPLLATAYICPIAVSGAMAAIATGYLLGRIGPAWTMMAAMSAFFTGITLIATMPIDQTYWAQAFVCVLVITWGMDMSFPASTVILSNAVSKRHQGVAMSLVNTVVNYSISLALGFAGTAEVNINPGGTSKESILAGYRAALYVGMGLAGLGWLLSLVYLVYDHIRAGVTLVRLKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQL6</accession>
    <name>A0AAE0NQL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_523179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="230" mass="26210" checksum="DCF12DFE667CDE67" modified="2024-05-29" version="1">MASSLGISRREWTMTHGYFLGMGGFAVGYPLTDNSEVLSYINSGDHSNIYLPLDLDHLNLLLFKPSFSARKPVKQYGIDAGTSTSSGVTAAAIPSQQPNEQKQHHQSKTTPQFLKDSIPYFNISKEDILDKSKRDDIAKTIVCIQTIWFCLQCITRIGLPITLLEFNTFEHAVCTLLIYVLWWHKPMDIRRPTVLSLNSRDPQHRALWAFLNSRRQVRDRFSARSPLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQR8</accession>
    <name>A0AAE0NQR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_189656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQR8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="81"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="569" mass="64543" checksum="CB841AF8F58DCF6C" modified="2024-05-29" version="1">MVLSSTAITPLAKECLASCLANHESCRKRARLSTIWSSDNSHIIRDLAVTDLMPRRLLQILPNDAGLLLVDLGEKADEFPFVALSYCWGPGGGNLMTTRDKLASWKTEGLTLDILPATFVDAVAVTRGLGFQHLWIDALCIVQDDAEDWKKEAPHMAVIYGNAVCTLHAVDSASAGAGLFPRDLTTVVPGVLDTRAWTTQEMAISPRSLLFGKDGAKWECREAKATLSPAPTELTGLEKHVEGRGLKELFTFFRDWRSPGHIRDDEPSEQGYMDLDFGSAYDLDGYLPFHHAWWDFVSLYTERNLTVESDRFLAMNGIAAIAQRWARVRNTWGLWIDGLERELLWYVDNSLSGEVRAARTSKWLAPSWSWASLKGGARVRNSLYEHVRGKQASKIPTLMIKPEIRIPYGTSFDQSLPIPAWRSRESRCIELKGDLREGEVVASIGPNGRRQYEVKLNRVGRWSEDEKYDFRPDVESEFPVGQPVKVWCLLVERFDAEHCSLPESVLLSLVLRQRGPETEVKVYMDDVEAIDLWDERTFTRVGYLETTFSVMREWSGIYDDFWWKVVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQV3</accession>
    <name>A0AAE0NQV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_501600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQV3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="71"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="810" mass="90784" checksum="B41CDD88B770F00D" modified="2024-05-29" version="1">MQPTSFGSGNQGQQVGHNYGTINAEFHLPPERPETPPQPFATIPFSRDPDFVNRGDLLDRTDQRCSEPAARVALVGLGGVGKSQLAIEFAHRVAAGQPRTWVFWVHAGTQARVEEGFRAIADAAKLPGRNQPKADIPQLVYNWLSNERNGRWIMILDSADDRDVFYNANSAHGPTSGDARDRRPFATCLPQSRNGSIIVTTRNKDLAFRLTGHRQNMIDVGPMAQPDALTLLEKKLGSPSDLDVAANLVQALDYIPLAITQAAAYIQARAPRSSPEKYLAEFRESERKKSRLLQYDVGDLRREGGASNSIITTWQISFNHIRSERRSAADLLSLMSFFDRQGIPGWVLKPTRIAKDAIQGRGLDEAGGGESDDSDDDIDGGFEDDVVMLRDYCLIVVDDAGDEFEMHGLVQLSTKRWLEASGQQEVFTQQYIERIAASFPTGEYENWATCRGLFAHAQMAVGYRPSEDTIETWATLLHNGGWYARSQGIYEVAQQMLAKARKVREKRLGEEDVATLASITMFSLVLLDRGRWEEAEKLFLGADHPSTLTSMANLASTFWNQGRWEEAERLEVQVMETRKTKLGADHPSTLTSMANLASTFWNQGRWEEAERLEVQVMETSKTKLGADHPSTLTSMANLAATYRNQGRWEEAERLEVQVMETRKTKLGADHPDTLISMANLASTYRNQGRWEEAEKLDVQVMETRKTKLGADHPDTLTSMANLASTFWNQGRWEEAEKLFIQVMETRKTKLGADHPDTLTSMNNLAFTWKCQGRHADALALMEDCAQARRRVLGEQHPYTLSSLTTVSKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQY2</accession>
    <name>A0AAE0NQY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQY2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="238" mass="25837" checksum="AED496EA05149CA1" modified="2024-05-29" version="1">MAAVFLDNQIFYTPPVVLGATLTSHHASARYADVSAAISGAPPVPPPSQNAQDSRHGGPGNSPDDALLISAGFRTKSRTSQFRHPAVGLPVREFLVNRVPGAPDTPNPLLSTSIASSAPVRHRDTDDEEHYGPIEDSDAEQSQDVRPRLRKRRRVNVSNPSPGGTAAQQQTHQFGADRSQRVRRTSCAIRGAGIDPVLPARYPHKVQPQKRRQPKPMLPSLRNGPLETRSSNALHWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS08</accession>
    <name>A0AAE0NS08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_139505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS08"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="578" mass="66873" checksum="2270363EF7959AC5" modified="2024-05-29" version="1">MRLLNTLTWEMKDFISDDDLPQYAILSHTWGDEEVSFQQWENRAQSDISTMKGYQKIKQFGQLAESWRLEWVWVDTCCIDKRSSSELTEAINSMFRWYQNAAVCYAYLSDVTYCTERSEMTRRFESSRWFTRGWTLQELIAPKRIEFFDSDWRIVGTKVELLVSISGVTGIDQHVLYSRELGTVSVARRMSWAANRKTTRAEDLTYCLLGIFDINLPLIYGEGGPKAFRRLQEAIMVTTHDQSLFAWGRLVEHPSSIINHAQHRGLEPLPWKSPHQREPLLGLFAQSPGEFRDSGQISPVDHRLAHHLNRERPPTIVNGGALLSLVIYETRLSVQYWDDVQVAQPQEVDVAILLCRLGNQGSKLVGLILNPWGDEYYSRTGDLFSVDAFISGMWLERLVYPRHIVPPRPTRLKHGDILLQRWTECLEKDGMKMPVTDSGPAWRTIWGDKVLRLENDAVGDEEVIFFYRQTHSTGFAVSLRRLPITLKEDGLGRLMVQVSQTKSIHGKTATATHWVPLREKEIPLNPGKSYFMSSPPDKWYTYIDHLLHISVKVHRRMIDINYGRYGWVDILEFEMTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS32</accession>
    <name>A0AAE0NS32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_520584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS32"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="758" mass="84386" checksum="5E3538CF9D45C6ED" modified="2024-05-29" version="1">MEIAIGAISVTRIAVSANSKLWELSHEWRDAPADLYKLRDDVTRAERFFSEIREQINGSRLMTGPRQRRSSNQTALPLQGQIPPAPPPMHSELAHLLESGAVILRNIEDIVDILAADKDANQKSAGKSKLDSEVTTSNDNKEKSLGKTNVIEMGKRRKLRWLRHSAKAIRLRKELAHTRANICALLISQNISVSADLSFSMESSQKEIMSHITRLSTSIEASSSSVESAQEAVMSQISALSTSIGTLSSSLESSQKEVMSHISTLSRSIETSRDMILVRVEDRIQAMEERMLLVGIQDQHAAIEQDSRPATTLGGLRHLITSYSWTMTLQRSMVGVMAVAYTSWNSSPCTDPQCRDMQWQRGRTRRDFCLAYQLPDWLARTSVSAFFSTNLNGSPQMNIRVYNRRGWELNGPQDLITRGDSLRKVAPSYPRAFERMLVDEKRNKGFASIFPVHKYIEESDFTPLHQAVLGVTHVDLEKMLQDPIHASRVDAKSSDGFTALHLAALRGDSQAAKLLIRAGAHLDAKTADKQTPPLFYAARYNHVKAAQALLDAGADVHIRDHEGGQPIHVATLFDKDESKDMLALLLKHGASVHSRDIGGNTPIQYIQHRGSIGAARYLLQNGADPNGASPNTSPPIHIAIEASRRGMVELLLEHGADISILDDEWETVLHKLALYGDAQMMHIFTGLPFRGITSSQKDKFEKTPLNYLNERNPSPEIRRAFNSLLESVERQNNNDLSVGIDDLTSDNEFFDAVEDFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS61</accession>
    <name>A0AAE0NS61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_139805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS61"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33524" checksum="AD5806DD0E8F5A35" modified="2024-05-29" version="1">MACLPFHSSCKRTLWDFLEFAGEFAGELAGPSYMHLRLEYDKDLVDTIMQELHEPEVGATLSKVNYSRGLSSHGGEWICIPGQEFLAADPFWCRGMEAVEAIVESSPFRRSFLAGDLGSKVAHDPLVALPDNVLYQMSYFLPDNSLFDLCSASWGVHSKLRNGNQFWRLRMKMSYPWLWELHWLTIMVDEDPFGGKDAKAIFLALDFFTVPREDAKGEYCASSIAVAFGEYASRLLISTSRVISREGRTRRWSWIVWTKVNATVLNENARRFSICLVSFIVYFWAGIGTSVKSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS80</accession>
    <name>A0AAE0NS80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_140376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS80"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="313"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="591" mass="62647" checksum="816F4CBDC248E5F7" modified="2024-05-29" version="1">MANPQDINSLLRLLDATNRPPAGQAPPQHQQGMPGPPPGPPMPVQYAPPPYATQQPPYQQQPSYPYPQPSGGGSIDLSAIRPVNSGTVPLAPHLADAIAKAKAFATEQGFKPYDRPAGGYPPQDSRPSDSRQYQRSRSKSPRGRDAFRDNFNPYRDERRGEHPGHGGPPPRGDFGRERSFSPGRGRQGFSPRGSNGGGRDRSPLRGKDDNTETMEIESSLVGLIIGRQGENLRRVEGETKCRVQFVPPTGQNEPYRYCKISGSRAQREEAKGMINRIIQDSGMRGPAPSGGPERGGRDSGRGGGSVPPVLKEGEDSLQIMVPDRTVGLIIGRGGETIRDLQERSGCHINIVAENKSINGLRPVNLIGSPSAARHAKELILEIVESDSRNGNNPGGPPGGGMPGGMQGPPRGGRNDNMGGGIDKINDSIYVPSDAVGMIIGKGGETIREMQNTTGCKINVSQSSGPGEVEREIGLVGSRDAISRAKQAIEEKVDAARMKSAGGGGGRGRGPPQQHQQHRDYDNPGYGQPSNHSSAPQQSMPPGNAAPAGTAGTEADPYAMYGGYENYVALWWQSQVAAQQAQGQGGPPPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSW5</accession>
    <name>A0AAE0NSW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_150097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSW5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3387123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="468" mass="51436" checksum="4A368EC957F27A88" modified="2024-05-29" version="1">MSVTRPATRSLLSGRLAVVVPIPPAPTCHRSFHSSAPLAVRSRPRFRNILAKDMGLDTPKKVESFAQKKFPKYSPAELAQLRTLYSPEQIAALQAGEAAIDPKDLTIQGRLRVDPYVLPYIDDFSDIQPIIDKRPRKNAPPDPNARFMNLDEFTLDLIQWADSDAARKGDVTGQLKKLTDFVADEYKNVAEGKWPGKVRDQAREAFMAYLQAQSGKPEKLGDGASVGGPTDADILEYILERSSMTDNGLKSNSSMAPALPNKVPGVAGLYKNAIDPEDEGLDDSGIYRELKKSTGMTVKQILGLTVKVLHVRSVVNQTRLGKIRSASVQVIAGNKDGWLGLGQSKAIELPIARQKATMMAIRNMKPIPRYEKRTVFGNLEAKVGGTIVRLNARPPGFGLRVSHRIFEMCRAAGIHDLSATMPRSRNPMNSIKATYEALLNQPNPDEIARGRGKKLVDVRKVYYGGATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT34</accession>
    <name>A0AAE0NT34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT34"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042196319" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="9785" checksum="87E50C76C92D4CF0" modified="2024-05-29" version="1">MTTSTILSISAYVALAMAAPSAAPDVAPAPAELGIAQSAASLGAIDVDLSGLAAQPGGGLVAADTCGALSPCVGHQCVRIVCCPQRTTIYCVTYRYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTD7</accession>
    <name>A0AAE0NTD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_521336</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTD7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="313"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="431"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="538"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3387275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="631" mass="68717" checksum="298F6065310549CC" modified="2024-05-29" version="1">MKISDVVSELEVEMEQSQNERDKRVEELWRKLDPAGHGELDVKGLKKGLKKIDHPMKNADHMLKEIIKTVDSNGDGKIQYEEFRSFVANAERQLLQLFKSIDRDRDGRLNKEELQAAFKRAGLSVPMRRMSGFFDEIDMNRDGYISFDEWRDFLLFMPTNHDHDSALEAALSFYSSIVTVNAEGDSLVSEDTLEGLGTTGFLLHALFGSLLKLANPGSTSYPRTTPTSAPLSPSDSPQSLPASDQDTATVNAASISPAYRSASAASSQIFTDVVGKRHVQIIEGAEQSDTWDISRLQEEVLEDEDTQILTNLLPETGYFLAGAVSGGVSRTVTAPLDRLKVFLLVNTKAGSTDAIATAKSGQPVAAIRKAGGPIKEAMVTLWRAGGLRTFFAGNGLNVVKIMPESAIRFGSYEASKRFLAVYEGHGDPLQISTVSKFVAGGMGGMTAQFCVYPIDTIKFRLQCETVQGGLKGNALLLKTAKTMWADGGLRAAYRGLGLGLIGMFPYSAIDIGTFEFLKKSYTRSMAKYCGIHEEDAAPGNIATAILGASSGALGATVVYPLNVLRTRLQTQGTAMHPPTYTGIADVARKTIKNEGFRGLYKGLTPNLLKVAPALSITWVCYENMKRLLELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTM8</accession>
    <name>A0AAE0NTM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_155437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1294" mass="141907" checksum="B6DF64E6EDAA48B7" modified="2024-05-29" version="1">MPRKTSEEEFDFSIFVDPSCLSAPMDDITEPTQQPPATEEAPILEPESTSAVETAAEGHPEAEGGVEEEHDTSSSSIEPFPTLDVDTTFEQDPIIEPASYEHEQEVFAEEQEDTLVDQAEEEPEDQEAEADVSATADDSILVEQNVVGETHVQQDAPVVEQEVDTVEQEAHAIDQEGVESSEDRLTEIQLDEDAHVQDETCEVDLDADADTPKPPNVDSDAEDDEGQLSQQPSFTERKTSLRTEALIQAAARAVIATIEGRSSNRNSTSADSIKQDDEEEADRSLLSVGTQDTYGNDETQSSHSASHNARRRESSQSAQSSDSQIHHTSTSRSLSGDDGGDSSSHHEADDDDVFSDRSARSSIGSFEGVTSNDDNPEEAKTPQAAGAQSHRESFDFKERSPRLSGVSTISGLSQYDKDDFVPTSRDTRMPFRTPSAVRAMQMTSPTPSVFHGGGSPRSSKRHTGGSTGILPTVSRLGSPVVSAQYSPKGRSTPTRFKSRKEAPLVLLHVTLLPLRWMWGDILNGMDAVNGKAFDVETGETFYASEQLKTLRDAWRELQDRVGDTVLERGILLPHPQNDYEVLEERLLEALELPVRRRARILECGHYLGPANEEDEDEQSDDEYASQSGQMKDKRHWCNTCRGEIRLEDLGPGKRVFRVKVYASNGLMKAGAWDACWKEMERVDSEVEPVVEPAVQGELERLAAIQIELEEQRHQAMERERFDEQKPKETAVADVHDEEDLVGDETLPVAADPELPYMDEPLQSQTSNMSSPPTSSMQITMHASPAQPPPSTIVRVQSPTLVRAHSSRSGRSEPIDTSEERRRRDEERLREIYGETPAPVVEHMDMLSPSTSMHVEPTSSSPRHPDSYIPPPTPRSPSEEAYERRQHREAGHTQTPKSYDNSSFSELLLEAFKVLLRDPKNVAIIVLLVLVWGFVVRPAPDHHLPYRYDPKQEVVMMQSGPDARVEVAVAAVQVQQPHMADLVGLNTPAVELLATSVTETPTEIYVSEIAAPSTVSEPLDEVPSVSFEYIEAVESVSAPVEDVGDLAPEAHVEASIDEQEPLTGVQASDKATEVHSDIIREISSHQGDEDSPLKSQLEAVSDGLETALLIEDGDTSANFVPVELNDTLEDLSGEDTATTPVPNAFESKDSNEPDPSVEFGPKQQAMVASDPLSASLIDEADLTNSATSTPDAPFKSLDNSEPTTSSHPCESYAKLHASPPAVLTERKTVRIYETITETVKVQITAAETASSVETAVPSTVEEVVYETETVRITVSVPMDDCDRPVPTALAGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU19</accession>
    <name>A0AAE0NU19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_162416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU19"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="35057" checksum="BC96C13D4D107BF4" modified="2024-05-29" version="1">MVLRTTPSSTASNPDLPLTQKDNPPAARLRCAADGEFKPRDNFSDKNLADYDYRARRGMATPGNSGIKCREHSGTPDDMLCRGPCNKRQAIKFFSRSTRRNGKMWCNDCTSWQLALDASESHKLLPPPGAVKRDDFIAPLPYVGHLKDDQVFDHEVDGARSVSGSVSASITASVSNFGSQPSRTPAPHWFLPPMDDTLTGSLGSRSSAAPSVSDIEAVTVSQPDQQRGTVTFNAWGPNGEQQRMTKCPTVVSEITTTAYTERTVQTAKEPVKVGKSGWAKPDTRRILPDMPDYLRFDLGNDDDDEMAPPSDYDGESEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU46</accession>
    <name>A0AAE0NU46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_521697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31907" checksum="5EC7E73A902E83D6" modified="2024-05-29" version="1">MAIIYPRRNEALEINRPGSDQALTVEGSDWLFAVTAVFAVSLLALYALTFTARAGERFFHYVFIVANFVGVIAYFAMASDLGWSQILQANNRDNGYTRQIFFPKYVLWVVTFPAAILALGVLSSVAWTTIFFNIALSWIWVICYLVGAYTMTNYKWGFFAFGTAAYLFLAFHTLVEGRRSAFRVGVSGHYTALAGWLNLLWLLYPIAWGLSDGGNKIGITPSFIFFGILDVLMIPVLSFATVYLSRRWDYGRLNIAFTQYGRVHAAPGTFPEKETAPATATPAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWR6</accession>
    <name>A0AAE0NWR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 17">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_463230</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 17"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWR6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3389238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="44567" checksum="C7997C78F347381E" modified="2024-05-29" version="1">MSLANKLSIEDVDLKGKRVLIRVDFNVPLDADKNVTNPQRIQGAIPTIKYAIDHGAKSVILMSHLGRPNGLVNPKYSLKPVVPELEKLLGKSVTFAPDSVGPEVEEIVSNASDGAVILLENLRFHVEEEGKGTDKDGNKVKADKAKVEEFRKGLTKLGDVFVNDAFGTAHRAHSSMVGVDLPQKAAGFLMKKELDYFAKALESPKRPFLAILGGAKVSDKIQLIDNLLDKVDTLIVCGGMAFTFKKTLYNIPIGTSLFDEAGAKTVGDLVKKAEKNKVKLVLPVDYITADKFAPDAKVGHATDKDGIPDGWMGLDCGDESIKLYKEAIDNSETILWNGPAGVFEFDAFAKGTKATLDAAVAAAEAGKIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKELPGVTALSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXV8</accession>
    <name>A0AAE0NXV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_463973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042134650" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="71156" checksum="EDC78FD4E0660711" modified="2024-05-29" version="1">MVLSSSLVALVGAAGLGLVSASPMVPVLETRHAQHSTPLDAIQNLARSLNALRLHGRDSVFSTNKTTLDTSWNGAILFSSTGANTTETNKDKNGKAQGTLSTSAGVEIRCDTCYIKGTASASLTVKGNATEIFKSYVGNIKDAVDNVTDQAFAEVKAAGNQILANLADGINRKDFDIPPPKINFDLDLPPLPSVIVNFGFEPGFELFLKLGIKLNAAATYTLNLFSSNTPIGIAVGNDVLCGVAVVVDLILDVKGAIDVTSGFHLKIDKPLAFELAMFSKNASSLQFPGGQFEFLPVTLESANIVLKGVLRVNLKAGLEYNQPKPIVTIPEIDVPDFFIPDDPDGKLDAIDIKFGAGIVVSAFANIAEFTTNITVGTFSTDVNAPKPRCALEITNEYKFALGAAAGASIAVGPHTWGPTPNKSVDLFHTTFASACATVGKPTPQTAAFPTKRDLLARAANALAQVTGFLLPRQALTPVTLSSATTFTGIACASTGFVNCPASLQVTSRFSSILTHVTSVAAGVTPTFPAAQISGVANSIPFGDAAKAIAEAAPPAPTQPPKFDLPNVGDIGDKIGNKTNEALNDAKAWLEQSSSNKIVLGLAVGLGLPLLIIFIHSLITCCRRPRYDSVPSKVPPPPPPGQTVINVGAPPQVPPAMPYKQPLMAVSDHGSGNSRPGSNYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXZ9</accession>
    <name>A0AAE0NXZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_492626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="30899" checksum="1990E5FBB7C64F01" modified="2024-05-29" version="1">MSSVPSTSGAGQVPVEWHPSALVQVHDGAGPEAAAAERAEFALIVLNQPLAKHMALSKRLWQNANVCIAADGGANCLHEAAGQWGDKCFDNLHAIVGDLDSLDDNVRAYYEIRNTKIVLRPSQDATDFTKSVDYVRTEFHTGNSPSAPLDIVAIGGLGGRVDQGLSQIHHLYMFQKHPQYKDGRMYIFSGESLTFLLKSGTHHIRVRDCPGDNDVFDKHVGILPVREPSRITTKGLEWDVTDWETHFGGQVSTSNHVLPETEVVEVHTTKDVLFTIALRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY03</accession>
    <name>A0AAE0NY03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_537746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982953" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="108" mass="11412" checksum="D6ACCB1CCCF6366F" modified="2024-05-29" version="1">MTKIFKILLVAAAAAMSVTALPGLFNRNTAADMLQVRNSAALPMRDDIREYPAPLARSVAQELAELEAREPAKKNCDGKCNCGSGCSCSGCAAATKEVDGKQGMRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY05</accession>
    <name>A0AAE0NY05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_464213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY05"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="281"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="406"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="624" mass="67481" checksum="AD38E93C3464195D" modified="2024-05-29" version="1">MAPYLNVDSQMNYINQTSDFARADAINTLKAVQQVVNGFFAQGSLRDKGFIPTPEPSPIPRPEELAQAITNDIVGQNETGVLSISVPMPPSGDQDMKDGPDARSVVVSESGTSIASGYTTNAEPGINVPASAVRQTSNVTQAFSGGADRTASSDAIDGGANELLNRANISDASGPSSEAVAAADISPRQQQDEPPASQPPSGTEPKAPTPPHPVGPGATGSLSPERLRFLANQISCSVDEMSSPETSELARLRTVTAAMELVGAVRPPPDTIMSLFVNMSMVSAVKVFQSWRVFDIMPAGKGESISYAELAEKVNAEEALLIRMAWMLSSTGILRHEEPDRVAHTPTSMMLREDQPMGSMFKIMYTNVVEASAILPAYFETYGRREPVGPAHIPTSFLAGKSELEYFELLNQDPERVKMFMRAMAISNRRVPTLGMYEMDSVLTQAAEEPDRLAWVDVGGGNGHTLKLFRQAFPALRAEQCAVQDLPEVVEAAKELAENDELLRGVQWHPFNFHKQSPVKGALIYYLRHIARDYSDSVLTNILRNIAQSMRPDSRLLIAEQLTVTPPPVYSAFKDYAMLTIGGKERTLEQFNAVGAAAGLRVSGVFRDSGTPHAVVEFALANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYJ0</accession>
    <name>A0AAE0NYJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="22342" checksum="BB6D7312ED05114D" modified="2024-05-29" version="1">MASSPAYSPGSPRHRGFRDVEWTAEDAPTPVYHAGSPKPSRDQGYTRTKAKHGTPISFPKQLIPAARDMVASMDKVAISNTALASTRFGLSKEDQKDLIIQINALKMNEKHEREVESQKRKNDYTHLCDEEKSILCRLDHQSDIDIGLVKAKATEEVNLLAEGKAAAEAKLVKFKATVDSEAKDKDMKNSINFERFRSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYV6</accession>
    <name>A0AAE0NYV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase F0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33592" checksum="48DEF24C8D2BB012" modified="2024-05-29" version="1">MERLGHINPFAKRDSHSENSVITYKVLTLLTWLLSVIVTIYYTYEVPHDGHLRHGRIWDQNYWYFSGFAQNYLITSLFWLFLFILQLVYITHLFSTNVETVNAACSVGSHFIFNNLLHFAFVMLFVRSHFVWAEIVLIINFFNLTILYFRHNTYPRFIHMPAVSGPLAWTFVAIYWNGAIMVHHPDHTVARIFANIFVWSILVYGMFFIIIYKDYTMGFSLSVLSASLGVAQFFNKFIAFQWIFAFTIMAMLFVFTVLVAVPAWTGKEVGWGRRQTADTERAPLLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYV9</accession>
    <name>A0AAE0NYV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_110140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYV9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="650" mass="73283" checksum="6B4A46C7E600BC34" modified="2024-05-29" version="1">MSQLHNIWPWPDGSRQTQSEVVQDITLTSPSSNMQSAPRQIKIIQMAGSTGPHAPRIAEEVWERWKPIIVENYGTNRMTQMQLKEYMEREHGFIATKRQYVHRLGTIWGIGKYKKKNSNNNSNNKRSRKRRNSDNPPDSDQSLEQPTFRPGNLRRHQDGPVYNAPMDSEEVRRLYRHAGDLCLAAFGDGHSAFQIYHKLYRDQSTPVHDVAACNRHVVDCNRAQQTGEHADLVEEMLQANINILYPKGSPPSWRAVLFHLIMAHRYDREPTDGDATSQIERVIDNQLLKTYNLAVIPQRGFLLDVEAYIYLSYSLARYNEATVDPDERININQILGEFIAQQPALINGTSPSCLLMCTNWCIGVLEGNPKMPAKFPSSNGNLLVGTYKVLCTLWCAWVHGAFPRSPQGNHRTPTIPPHPATWADQTVSQLAISPGELLTNVVCMIMTAGPQQQGRNSTIRDALEGAKSLQKLAVEDGQIFIHRFLGQVRKNNDRRMTHQMIVDFDADLATENWELIKPFRSFIADEFKLVLPELSGEAFCLPVALNTGEDDDEEDYDDEDVYDEDEDDPYTTSQYPRQSSHSRQHAYPASPLGGGPNLRPCMGMDKLQIGSRPSSDDGRRGGRGPTTTPLRQHQGGNHASSEDAADVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYW6</accession>
    <name>A0AAE0NYW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_105815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYW6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042211502" evidence="2">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="27625" checksum="861E27E15D3E774F" modified="2024-05-29" version="1">MILAMLSIILLSILVAGCTSESLSGVYLLSLSYTNSVPPATVPMDQDPTIINPGLQTVFAAIATNNGSSSPAPLALEVRVGYMGMCLSRSSGGWFCSTTAASLASYVRDTGSSIVNRGGSGDPLNLIHVGDAFKGGVVFMALIIVSMVFALFCIALMATFPGWHQEEDDEGSEREVKPFPSESVSRLACASSMVSAALAFVSAFWQHLSSAAAGTMVGGLTYGAATAHTGVSAIVLGWMGTSLILLVVAGLVLMILSFKVLRQIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZI4</accession>
    <name>A0AAE0NZI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZI4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="42630" checksum="272E2AA6ABC9259D" modified="2024-05-29" version="1">MDLTVRAASAEKEQLQQRYEASSSSLQRPQLSGSHGRGSGSNGHLSIGSGSVPMSEEELESQFQPSPSPPVSHNNTTSPNNLRAPTPPPYSGPSTGGSTQPSASQEPKGPKKFPGLPLLDYQLYNPPLSNLSADHTTLKTSATYISANASALSSFIRSQSTIPPKPQIHITGKQHGFVDFAIKVNLMNLLVPENPRKRMDYIRCVATGEVALRGGTQPSAEPEVSDGGLDEWARRFVEDSASVKTFLLERVVINMDLNWIEGQIRSMIATTSYKGEVSVSFPVTHAKVVVQNPDKVNKFFTSVSTLFAGKKKYEVVKAVWPFATHKSGEPDRHCAVMSEHAWWREWQNPLRHAIVTRRQGWVSIEDKLEFLMEGTDQNSAVVSWGHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZS6</accession>
    <name>A0AAE0NZS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_122681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="46203" checksum="EBA36102A0F93A54" modified="2024-05-29" version="1">MNQTKALGSLKRIFPSLHQPLPLSETESQRLLNALTTSFRAQLDKEHGNTYDLRKSKIPSPPLTYLPSTPAPSHSKDVSFRPTESHLRAILSNPLFASSQAPTIQDVLPTLGYSGIVVGKQPKQVFEHAVSKGLMTVKRAHGFLLAVAREIRQSNFQTLSQGLSSSGAGLLVIQWLRASGLENNLSFLDDDNFTLNLMRFMVAEGLEPIAWTWMQRLVSEDTMGLKVGPRRARVHLADAIVAAKIQSGAELDDAMSVVLKLRDFMLHNKAPLRDMSRAWRHLAWRATVVSWEHTTPTPDVFEAFAAMERSIYSDWLPFHEHLDLLHPVAPNPAGAIKVLTDDKLQTDLRTSRARARRWGPEFVDVKFVEHITSLGLDTVRHLTRIGEFADAEKILQIIRTHFMPMDKPQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0I5</accession>
    <name>A0AAE0P0I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_131316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0I5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3391066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="510" mass="55865" checksum="D38166A21D0B3EC2" modified="2024-05-29" version="1">MDSQGFREAAISSIDEIISYYDNIGTREVVSTVEPGYLRKLLPSEAPDQGEPWADIQKDIEAKIMPGITHWQHPGFHAFFPCATSYPSILGELYSAALSGACFNWICSPAVTELETVVLDWLAKLLGLPECYLSPGPTRGGGVIQGSASEAVLTAMVAARDKYLRETIPAELDGHDREDTIAHKRSRMVALATSATHSSTKKAAIILGVRFITIPVRAADGYALTAPVLAAALADCRARKLEPFFLTATLGTTDTCAVDDFAGITSALADFSPAGSPGEVWVHVDAAYAGAALVCPEVQTATNIAQVASFHSFDMNMHKWLLTNFDASCLYVRDRSWFVQALTINQAVYNNTASDGGLVTDYREWQIPLGRRFRSLKIWFVLRSYGAEGLRAYIRRTTKLGEEFANWIRDRPDLFEILTGPSFALTVFRMVGKSGEGEASSSSSDEEERNALTRTLYETVNRSGKMWVTSTVLEGRFGIRMMTGVRTTEQEHVEAAFKALVDAAEEIHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0L5</accession>
    <name>A0AAE0P0L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I 3-dehydroquinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_557945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0L5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3391082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="819" mass="91304" checksum="B05A32806E5283D4" modified="2024-05-29" version="1">MLPTPPSRESRVAMPGIKNERAFEPNASIVLVGCRGAGKRTLGFMGALHLRWRLVTEDHYFEKVTSLSRGQYLLHHGKENFARQNIDVFKRMLDSNRTGCIIECGMSSFADEAQDALRAYSKSNPVVYVHREKEHILQLLDAADAEQLLKADEGHRSCSNLEYYNLYDSSNSTPVPASGTSTPMDRRQLGPSKLLGAREDFTKFLDFITGRGATRAWLESPFSVAAIPPELRSYSYALRLRLSYLVDMDLEWDDFEARGDCVELIIDHWPDDLLNVIATQVALIRRKLGVPIIYHVEENPRGERQRTPAEKDEMDSELLELGLRLGVDYVSIDLQRNEAFVNRIFQHRGRSKVIGNYWYLGFGALPWHDDKQIENYGRARALGCDVVRIVRFCAGDSDVEILQDFKKRIQNAFPDPRPPLVAYDFSVLGARTPLQSRILGPVKHPDMENERDHLATICTYNHTYELLFRQFLLDPLQFYVLGSNVSYSLSPAMHSAAYEFSGMPHTFQAVTCSTLDSLNQICSSDSFGGACLTAPFKVAIMPHLKVKSHHATAIGAVNVLLPLRGQTNVILDHANSRNKAGPARDFFGDNTDWSAILTCLRRAISPRNYVQPSKTTGLVIGAGGMARSAIYALIQLGCRNIFIYNRSIHRAAEVATHFNKWAATPQGVTAAASGTLAANGVISVVPEICRVLPSLSEPWPRNFQLPTMVVSCVPATSVDGNPPADFEMPLDWLRSPTGGVVVELAYEPLVTPLVAQMQAFRDNVSPSWVVVDGLEVVGEMAIEAFELMTGRMAPKRLMKEVGRRTWEQQQQRGGASSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0N5</accession>
    <name>A0AAE0P0N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_539733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0N5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="53120" checksum="96FB5B50E7EA6A03" modified="2024-05-29" version="1">MAPSMSVPALPEIVSRPLYRGTAYLRSKLGSLTWGPGLSVARPAIQSLFAAIEIGTLLLVDEPAGQRFVYGQNLETLTNGVKGSRKATAIPRVELVVKSDAFWIRLFLFADMGFAESYMLGEVECADLTSFFQLFIVNRDKLNNATTLSSTISNAATYLARSTNTLSNALLNISAHYDISNDMFAAFLSPDMTYSCPIWKVPSSQDHREESLYEAQMTKLHRFIDGGKIKSTDHVLEIGTGWGSFAIEAVRTTGCRVTSLTLSKEQKVLAEQRIAAAGYSDRIQIKLQDYRDLPVPETPYDKIVSIEMLEAVGEDFLSTYFACINCLLKKEGGIAVFQCITMPEGRHKQYSKSEDFINHYIFPGGYLPSISQLINHISAESHGTLIVENVENIGGHYAKALRLWKEDFLANFESKIRPALRIEHPNLSDEEMNVFRNKWEYYFTYCEAGFMTKTLGDVIITVGREGALELMEGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3M5</accession>
    <name>A0AAE0P3M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3M5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="198" mass="20420" checksum="B8B6BD8F53B5B9D5" modified="2024-05-29" version="1">MFSFRKKYSGPAEAEFKCIIEGGQIETGEDIEFDATPPGKTTLDDFCDWAASFYTLPGRVSLHLPNGDELRDLKAHIGDIVQKLPQDPESKCLRVRYDEKVPVARGGYASGAVVTSSNSGRAIAQGGYAQGGTFESAHDNLHPSSATGGNATGGSGWGDSVQAGSARGGHSSNPGGTAEGGSSAAGKATGSMPDKVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3R3</accession>
    <name>A0AAE0P3R3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ice-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_516020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042041490" description="Ice-binding protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3392801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31315" checksum="3A0CB2686FDE8F69" modified="2024-05-29" version="1">MAPSPFRLLRAALAFSALANAQVFVDLGTAVKFAVLAGAAITNTGPSVIKGDIGVSPGSSITGFGSPAVVNDQQYPPGNPAVPLQAQNDITTAYNAITNQPTTMVLTGVDLGGLELIPGVYFFASSAQLTGTLILDGQNNPDSVWIFKITSTLTTASASAVLLTNGGLPCRVFWQVGSAATLGTTTRFAGNILAMKAITSNLGASNIGGFYARTAMVTLDTTVIDAAPSSIYNPFDNTINHSIDNTNDDTINHFIHNPVDNPVNHLFHHLFHHLFRHLFRHLFHHPVDNLLNNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3W4</accession>
    <name>A0AAE0P3W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3W4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="125"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="565" mass="63154" checksum="B21B5BDAA3A1E3A6" modified="2024-05-29" version="1">MNDRHIFVRLEDDSAYMKPGALVVCRLSLSWITNEKRQSRKRISPLSFYASEDDPCASFVPIRPVHSDFATPRVISTARAFIDECRGGHPECEPRTPTRLPTRVLDVTGSQVKLHTPGCHELGEYVTLSYCWGGPQPLLLTQHTVDEFRSGLDESRLPPTIRDAVTATRLLGFRYLWVDALCIIQDSEQDKLFEIGNMGEVYRNSIVTLSASRSSSVNQGFSPGIKGQDNGIKVSGSSEGVAVELSLAGGHKGRLNLAKKIYDQFEALPLNQRGWALQEYLLSGRILAFGNEAVWMCGKHKHRPLVPSIMYIAPFPSLARTTLSAVRQLKADERASIWADVVNDFTGRDLTVADDRVWALAGVINVFQVAWADKCMWGLWRSNFVVDAWWRRSRHAKPALSNTRSKRAPSWSWMSLNSQVQQRDMAVRSTTASLVSVADDSGWAINLHARLLPTPHQPDVELPNTEAAQSVVVQAQDSLSLLTSVLRHTQQQQRLILHMDLLEDEVDGKPKLLLQLGEHASGFSEGLIVVQEMAGDITFRRVGFFESCDDSHLWASAQYQTVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P549</accession>
    <name>A0AAE0P549_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_457463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P549"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="34458" checksum="D5DCC3D5E48BD0C7" modified="2024-05-29" version="1">MGASSVRTESYSGSSSPRMADAKMDDNASVDSGFGSNSTISLPTVSFTTSHLRHLNKQLENMQPMDILRFCKILFPNLYQTTAFGLTGLATIDMLSKIQEQVPSSSPVDLIFLDTLYHFQETYDLVDRVKARYPNINLHIFKPSGADTVSEFEETYGEKLYEMSADLYDWIAKVEPQQRAYTDLKVAAVLTGRRRSQGGQRGDIDVIEIDEERGIVKINPLVNWSFQQVNSYIKENNVPYNALLDQGYKSVGDWHSTSPVKEGEDERAGRWKGQDKTECGIHNKKSRYAQYLETIAAQEAQQVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P589</accession>
    <name>A0AAE0P589_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_387858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P589"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="124" mass="14127" checksum="64088C75A094CC2B" modified="2024-05-29" version="1">MSSKAKQPTGQTKRSAIADVVAREYTIHLHKRMHGVTFKKRAPRAIKEIKAFATLSMGTTDVRLDPQLNKKVWEQGVKGVPYRLRVRISRRRNDEEGAKEKLYSYVQAVNVKNPKGLPTVIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5H9</accession>
    <name>A0AAE0P5H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-amino-3-carboxypropyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_458755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="95392" checksum="4E2B7E2586E09C78" modified="2024-05-29" version="1">MASLGGNISPPDIDSKLLYVGIAGVAFFTLGLFQLSSRPTKEGTYEPSFLKSIVVFVYSCFLKPHSASSKGTQQDALESFYSSQAGVYDVTRSALLKGREDMLALVAAQLLVKALKDGGAGAQPKRTWVDVGGGTGWNIEAMSQYVDVPSFFSSVYLVDFSPSLCEVARKRFARLGWENVKVICEDARKFRLEDYENPSGDRTPTRSIPSFFDQKRPEHGGADLVTLSYSLSMIPDFFSAIDSLSLLLAPNGIIGVADFYIQSKADFAFRNYTGGFTGRHVSFLGRTFWRAWFDLDRVGLEPARRDYLEYRFGTLLTANLRNYKLGCIPYYVWVGCQKKPFSSTSLPHEIVERIDALATESPYLLPANKQSVTNVLFRAVEKTAPEIRSKAFDAAVQNLSANLPLPSFFYQNHHWRIYYDDQLKKHTQFNDEYIYAFTWEDSRVDDRLLKLDPDDVVLAITSAGDNILSYATHSPARIHAVDLNPAQNHLLELKVASYSALPYEDFWKIFGDGKHAQFRSLLVSKLSPHLSSRAFQYWLRNSDIFTKARGRGLYDTGGSKHAIRIFRWISYVFGCRNAVKEILAAKTLNEQREIWHSRIRPALFSRLISNTVVSSETFLWSALGVPKNQLAMIESDHSSSEAVNGSSPTAKNTRAHAVWHYMVNTLDPVIDQTHIAGDNPYYHVCLEGSFTRRCHPEYLSAEAHARLSRPGAFDGLRIHTDEIDEVIARFMPGTLTVAVIMDSMDWFDSGSTAAARQITKLNRALKVGGRVLLRSSALTPWYIREFEALGFVGTKVGNRVPGECIDRVNMYASCWICTKRGNLPPPTPELEKVRACGEVNEPVWRPLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5R6</accession>
    <name>A0AAE0P5R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_459287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5R6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="22622" checksum="7229D370A4DC9E08" modified="2024-05-29" version="1">MDKFLGKVLGGDNDELQQHSSNLYQGGGNIPQGGAYPAGGGHSYEEDDDLRGAAGHASKHADEDTSFFSEIIGQLDQKREQVATEDLDEEDAVAQHKSFFDNSTPNPENATSSGMGAAAAMEALKLFTSSSSSSSQQPQSQSAFIGLAMSQASKLFDQQASAGKVSSGADKQSAVMKAGEMALKMYLKSHGSQGGATGAGGAGAGNNLSGLLGMASKFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6A2</accession>
    <name>A0AAE0P6A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6A2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="123" mass="13766" checksum="531EE650FCF03020" modified="2024-05-29" version="1">MPNSDTTSLLARYASQLIAQIFVLLSVSGLMKQAVGFWGRTNIKRTARLPAFIWLCPFPHHATSYLSTLFLTNADKKGLAINNKSSQLVVSYNILSPFLFLPVSAAFNHAYKKSPRWVRLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P701</accession>
    <name>A0AAE0P701_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_461058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P701"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="210" mass="23438" checksum="B8689BF5025F8217" modified="2024-05-29" version="1">MSRFSMSRLLARGLAQTTSRPQCPTLSAPLWSRAFSQSAPRRNDRPQTPNSNSELLARTALQDSIGINPFGEADLFRSELSPLPDVAEPYHFHIYSHKHNTHITVTNPNRDALISLSCGNIGFKKSQRKHYDSAYQLGAYVVDKMHQMGIVKDIHKLEIVLRGFGNGREAVTKVLLGTQGLSLRDKIVRVSDATRLKFGGTRSKAKRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P861</accession>
    <name>A0AAE0P861_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_533609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P861"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37672" checksum="846187166CD8A6D6" modified="2024-05-29" version="1">MDDTFRNIASELFKAAEEKRRASRHDAYLEGFIAGYKKAMADADTFKLESLNALHQFAQAAAADRHRVSGTWTQPVTPDRKGMLGTWKESEDDNIDVLPANVKQTSAIASEKAADAPTTSGISDKVSDTMSQADVSPVGVDSDNASDAPTSPEIDHDIKNMHTKTAKLKSGRESKFPRIDIDDPSKANTPTKPTNDDVLYGIPPASAVKPVNPFEAQASNLVVRPLYPVFNYFESSRRCPVRLDADNKIVTRVSAFAILVGPVTEELFQDWIKMDWGARSYFKTKTRGMRDSSWTTDTAGKRYTILTYETPQAAKDALEVLQNWPCGGIRLWSWPYQSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV42</accession>
    <name>A0AAE0TV42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_560687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041920862" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="196" mass="21333" checksum="660FFBF0EB7B338B" modified="2024-05-29" version="1">MKPFLLLSLGLTSALASPVINTPTAKRDIAADVSDDIFTLVSANLLPELFAQATFANGTLPSTTNNANATDLDDAANNLNKRADFCYQVGYYLAQSDVNNWGNAFQNTAGTFWMPATSWASWNWDSANIKVCAVNRYIAVWDGSSVPYWEIGWAMKAISGDCPDSWYHTRGGRITGHGTNGRGIHIYLTDTSASCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVA0</accession>
    <name>A0AAE0TVA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_194916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3380964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="43593" checksum="A003AAA45313E601" modified="2024-05-29" version="1">MPSNQTMSTPSPSQPRVSQPAGGNDSTLATTAVSGLVIGLAVVSVALRFYTRIFTRQGLRWDDWMIFIAVLTTLLTAALLLYGNDVSPNGLWVSENTDPNYVYSEADHLYLKLSFISSVLYFTIASTTKLGILLMYNRIFFVSDAFRVQLWITSALIVVFWIGCTVATLTNCIPLEWSWINSLADPRYCFNYNIFWMAAGACEMFLDVLVLTMPISVVIRMRLSLRDKLTAAGIFLLGGFVIITGLVKVILGYPPGSRVPSYHNTEVWTTVHTGMAIVCASLPIFKPLLWRIRSSSFAAKIFSGSKSSSHGSSSWSTSRKTNTQTDNGIITSTQPEPEVTKVEVSIGCMQLPPPETPRDDQFSTIMQLALLERGYTLDEGEGPRPDSHGESHVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWE1</accession>
    <name>A0AAE0TWE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rtf2 RING-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_217675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWE1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="284" mass="30655" checksum="86E8677E7A634900" modified="2024-05-29" version="1">MGNDGGSIPTRRELVKSAARAPTVSELKATALESLGHAWSHDPVTSDPLDLENAVSDWRGRLYNLESILKALIPNPDDTTSTPNDESPHLDIASAGIKSLRDVVRLKLKRYAPPGSKGQEIWACPVSLKELGASTKAVYIVPCGHVFADTAMKQIQGDACPECSEPFVPRDVIPIFPTDKSDIEKLTARADELKAKGLTHSLKKDKSGSKKKRKAEEANGSDAVAVDLAEAEARRKDKALKPPPNSDTPSRVGGINNALTASLTARVLAEQDERNKRRRLAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC7</accession>
    <name>A0AAE0TZC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_178318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="551"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="700" mass="74104" checksum="0222E518456B97D8" modified="2024-05-29" version="1">MSVSGGRGTEMQHYSSSPSLSSPPSALSEPSSPTRFLNAGRANIEMDEIIVDPGAAPRFTLMQQQQQQHQHPAPPPDVPLTIAGLPKKRPGRKPGSTVKPKVPGDGSSTNADQPKQRRPRKPRDPNAPPVQRKRKAAATEGIDAPLDPERSFTGPPATRRPRVTALMLMRPSIPQEVRPAPSDPVFPQVLPKRESLVSMQSILNDDPPPKAPPPVPAPTPGRQMFDPIRGNYDPIRESMASRDPYGTGPLGSPRAPSHSQAVNRPSASPSIASLVDPQPAPNVMSPLPSHTYNPIPPVRFQETASLPPSPSHPPVRIPPQHTKPQIVEANRPPPPPAPPAPSSKPEPVKTTSSFTSMSIIPASAAAAISAAIPAPMQSKKVTAVVQQEREAHKKASSNSSSPKVNGLKDKDALPTIPASSERSILDFGKVNPGEETNAPSIVLHIPLNGETNKYVNFLRMAEERYGWDALHPRLAANRERKARIAAASAALEKSGSGRESGDEMEEENIESDAEVSNVEMSGVANGTTAAAAGATSGPEGAEGVPTKPARKKRNFKEDEYDKDDDFVDDSEMLWEEQAAASRDGFFVYSGPLIPEVEKPVAPVAPKRGRGGGRGSRGGGRGGAARGEGTGRGRGGGPGSRGGVTRKPRITKLEKEQRDREKTEREKLAQMSSKAGSSAYNLLPLSAAPAPGASAAPGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0X2</accession>
    <name>A0AAE0U0X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="32538" checksum="3521A4D476374A06" modified="2024-05-29" version="1">MCARRICGGERGTMYSAPSPPPAAGMSLREATLADLDAMTWVLVAASPLDPVYPYRFPDRLSYPAEFAQLCRQKCREYLATSTVMVCEMEAWPSFPSASECGQKARRVVAFSAWDAPVAQSTPPHVAEPLSKPVHNPVSPVTIGNQDRMNAFRKACQENKASFFDARYPRGHMFLKILLCHPDYQRKGAGQALTTWGINRAKALGLNTTVFASPMGHRLYKKLGFQPIGSFRVQLVGDEDFLEIPALIFKPQDDGQHEVRPVKRAATRETMVLRVQSTFHHTREIQVRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U103</accession>
    <name>A0AAE0U103_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic apparatus protein p62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_146599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U103"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41234" checksum="27A47954C15E9684" modified="2024-05-29" version="1">MAAFQIIRIPRTDTSEEEGAYILGQVTPSSSSAGSKLLNLRFVATEGEEPYVVKLRHDRIGELKVSNSPCSPDEWEAILKSVLLNIKPDGDGIDGIEAGAEAHVGKTVTITIRRRVAGINQRLGTITLNHKPDEGIQLFDWCGAAALGRQKAEEAAADETAKVAILESRATELKNQIEELLESKKARETEILQKVCALLNEKKVKIRKQQRLLSMANVNPYALAGAAASQATSPASQSVVGRIPKASRAGKRKAGGKDVADGDGSMSDDSEQFEKMDVDVKDEQATQPPPPPKEVDSDDRETSDDDDDDDATGSGPDDEDEPLPPPKPEPIKAAKGRPPKGGAAAKGKETLTMHPKRSTRTTRATASPPPPQPVDGSETESDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1P1</accession>
    <name>A0AAE0U1P1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_470548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1P1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="42360" checksum="3160E654A392499D" modified="2024-05-29" version="1" fragment="single">MNCSCRTAALKVFVRSIAHIHVPSAAAAARALPRAQPFPGCLPVVPNLTGAAGSLPLVASRGIHTTTTRNGELETALAGGRHVEPKHGNTPSNSSAWKDSAGGEVASRSKRPADKNPSPRSSGARRTKPQYRPSRAPQAGGRDSQTGGRRPDNKREVAPKETGGLEYKGLEALSKPPPDWREAQAGRRKQRRAPFKYKEDAFLRAEEVIKESKEEKEDDDEPPTKTNWRAQKEALKKKFPEGWNPRKKLSPDALAGIRALHAQFPEVYSTEVLAKNFEMSPEAIRRILRSKWTPSSEEEIDRQERWFNRGKKVWARWAELGKKPPRKWRAEGIVRDPIWNEKGWPKPKKVHPVEAEEEPTTEEKKRMRAQQKLSENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U206</accession>
    <name>A0AAE0U206_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_448724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U206"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="505" mass="56769" checksum="E3D7E175586C4822" modified="2024-05-29" version="1">MALHSDLLPWYFPSTGLLLVMGVAFTAFVCHTCWVYAQLRHFPGPPLAGWSRLPLIVWTMSGRAHLKYQEISETYGPIARIAPTVLLSSDVEFMRKIAAARSKYRRNEWYMAFRFNPDRDTIISHRDDEEHARLKMKLAPGYSGKEIDGLEAKIDANVKAFVKLIETSYLSGPSDTKPFDLAEKTQFFTLDTIADISFGSPIGCLANDSDMYGYLKQAAASFPFFMVLGLFPRIMHILALDSVKRFLPSAKDSLGMGRIMRLASETAGKRFPLKDDEGVHRDMLGSFIRHGLTRAEAEAESLVQILAGGETTATTIRMTIFHVSTNPRVLNKLRAEIFRVRPSSPLTDAEAKNMPYLQAVVKEGLRIFPPITGLLFKDTPIGGDTYDGKFIPGGTAIGFSFLAAVMDKKAWGEDSHVFRPERFLEGSDEELRNRDAMVELVFGFGRWRCLGRNIAVSELTKVISELLRTFDFSVVNPMNPFKTRNAGIHLQSDMWMRAEKVAQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U327</accession>
    <name>A0AAE0U327_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_95271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U327"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="256" mass="29472" checksum="2E6305FD5D6BDBCF" modified="2024-05-29" version="1">MIPLRTPFAACPLSHSLPAGGRPYPRCLAAKESRKRKRSSSPCPATMKKRKSKSSPSCREPHPTPSLSSAKRCDWSRLCDLECLDRRIAAQPPAHVNIASPDASCSTARCPRLLLRFQIAPSHPYHQLYKMLTLDLAGTSQMRTKRERAMMMATMISMTRKMPVPKRKRRMVSQVSSPILMPWVREILPGCGRFMYQRSCKALTAILAWLFFFFSRHLTNILFRCRSSQKEGEDNRLRLRRRSAEERQGREERRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U493</accession>
    <name>A0AAE0U493_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U493"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="38765" checksum="BB4459090FCC6EA3" modified="2024-05-29" version="1">MGSLQLSKQRGLPPTSALWHYHHALNELGKDFADPGRRATPSLVAALTLLSYFDMWYGSVEQSRKHLESAMPILGNMRKDLDSTLIQHQDRLHGVYPTKPRQARPDQFKYPLWLLCKADLQLAGHEHLRDLLWSFCKVDVTLSVISGKPLIMTYSADVPDGFMDNDSSSILRAPRHDVIPLLSQAVLAEFLPQQPRSDARVQLEDTSNLRTEISYQLSWLELYDEPKTAAHPLNLHMYREQRERNRVVRRLNDIARITGCELATHARNRCQDIWERLARSKVAADYYPVLGGFLPASTLEKREDSESQTTRDHAEETTRSDKKGKRKMVSLLDDKLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4G8</accession>
    <name>A0AAE0U4G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_446440</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000640">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="672"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3390310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="735" mass="81237" checksum="22FF6584EDE2B6E0" modified="2024-05-29" version="1">MDDWEPPLPAGYNDANRAFLQAFMARGSLTLVEAQKLLAEIKSAATGEPVDSRSVTTADFENHVRTAREAVSGLDFDILNMKHQARGGERVWALVNAHSDPATQMATTRTPEEVAYIKRLLDAMFEEHNTPRMEVMAVDEAQAIKASRPSRQQRESAAHAHVNGEDGESAAGPVDRGLKHSEVLALLSSLVAEGWLEKSRDGFYSLSPRSLMELMSWLMATYNDPDSEDEWQHIKFCEACKEIITYGQRCTERDCTVRIHDICAEAYFRARRETKCPRCQTAWDGNHFASKMHAADGVGEEGGASEWWRRRRGRTMMMRNSFPLDFTSVRQADRQAQITAAMLEYFAYKKYKKNKAEKEEKGKETGDVTSTSAGTSTPRPVLADDDERFLERLTSTAVVAHDENDDDRPALPPRVKTPDLTWDSDSESFVRSDAAPKDKDKKSTANRLSLLLRNVRRKSSSSSPSDATTNNNKNSSSLTVPVPEADRERDDLTRVLDDLNLAARNNKAFALSTESSELVGKFTLVLKDLVNGVPTAAHDLTHLLDDTDGTLAKNYEKLPKSLKKLVTQLPDKIKSNLGPELLAVAAEAQGLGAADAAAKGGMKGAAKRMLTPSNLKDLVTRPGAVVSMLKAIMNALKLRWPAFIGTNVLWSLALFLLLFVLWYCHKRGRETRLEKEKTDAEADGKDTIDGSSRIEELPDDPTLPAAGTPVVVEPPRDEVAFAPAPRRSGSGRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4N1</accession>
    <name>A0AAE0U4N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_121685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4N1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042019819" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="126"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="420" mass="45773" checksum="CC25CB227CBA4DB4" modified="2024-05-29" version="1">MRVISLLSLASCAGAIRHQVSLQSSSSPDSCLWRPPPPRLACGIDEIEVSSKARVKSASKSPPPSKWEGPRGCVEQYCIFSNQGFEGGRGIVAVTTNANIQNLKALEKKGSAASTAQPASSSGNRPAYYIAKVPGKGLGLISNTTLHRGDVLMKHTPAVLIHRTFFETIHPATQAPLLKTAISHLPSALRKAFFSQMGHFGDQAHKINDILATNSFQMNLGGHDGHHYGNFPEVSRFNHDCRPNVAFYLGGGGADDLTHTTTVVRDVQPGEELSISYLDSFAPCEERQQRTFEAWGFSCSCSQCALSKGQVKKSDKRLKEIKEIEVKLSDFSGRVTGAILKKLAKLYDEERLDANRAGGLTLIALNYNMLGDEKNAKRYARLAREALVIENGPGAGDVSAMEELERDPRGHFTWRGRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4R7</accession>
    <name>A0AAE0U4R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_123303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="297" mass="31358" checksum="8F2423362ABC64B8" modified="2024-05-29" version="1">MASSSRRGPTTEDLDEQSPLLKHNASGSGFSSINPVAPRPASIKTDIPASEPTSQPEPAPSVVSDAAPVPAAATTPTPPAALVKSDTDATWGDAAGLHVRQANDENLVIFRRAVGINMGLSAGIDSRSLEEGRQHAMGMYASTLRAQSRKNIMYLILTTLIYTSHFSQIIVGAAMTALGPTAGEHTFLITVLGAVNTIVAGLLALVKGQGLPERLRKDQAEFRKLQDWIEQTEALLAVGVIGRDRKEVGYLVQVAFKKYNAAKASEENNVPENYVRAPGDVGNGDPPQRSSSPGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6R4</accession>
    <name>A0AAE0U6R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_5493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6R4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3392962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="307" mass="33930" checksum="DF8B240B02EAFB3B" modified="2024-05-29" version="1">MASPVVTSIELTSLPKVASGKVRDLYEVDDKTLLFLTTDRISAYDVIMGNGVPSKGAVLTQMSAHWFRVLSERVPGLKTHLLTLAPPTSLSPAEKDLVRGRSMQVRKLKVFPIEVIVRGYITGSAWNEYKKSGTVHGLPQPTGLQQCSPFPKAIYTPSTKAPLGQHDENITPAQAAKIVGERYADRIEALALQVYNTGAAYARERGIIIADTKFEFGLDQETDQIVLIDEVLTPDSSRFWPADEYEVGRDQNSFDKQFLRNWLIQEGLKYKEGVAMPADIAEATAARYKDAFQRLSGKTLEEALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6Z0</accession>
    <name>A0AAE0U6Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6Z0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="33444" checksum="38EEF3373F576354" modified="2024-05-29" version="1">MDSGTKRATSVKPENVKVKKGGGFRVKGEFDYNFSLSSIPLAPGANPVKKDEKKVNPFSVSEAPKYQDFGSSATACNRAARHRRHYGNSIVFDNKKVRVKAHYDRNRSQVDFTALDNAVPVAGRTLTVIKNVHHGSSVTGEIDMSFSVDVRKFRGVTSSLSLLSNDPTPSMKTGLGSNMPTFKVDKADDFFVFGGSARNDENKVSNCESKPAISATPAPVPAPVTAAPTPENGTKQNHFAASSIRRIPGNLELRDHAPNLWEGDLSPRDHSLELCDHGPDLRERDLKLQPILCQVRHRPDSRSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7A6</accession>
    <name>A0AAE0U7A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_9194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7A6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="76" mass="8460" checksum="2A312703655835AD" modified="2024-05-29" version="1">MALGPLWLAAMRFCRGSILQMNDATGFFFLGSIDSPTLPNCRPRAGLHLHTIEEFKITQSGRSFPLSPFDPQFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7B6</accession>
    <name>A0AAE0U7B6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_10414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7B6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="262" mass="29671" checksum="536AC1C9FDE3E7F8" modified="2024-05-29" version="1">MGKGPKKHQKRLSAPSHWLLDKLSGVYAPRPSAGPHKLRECMPLIVFIRNRLKYALNYRETKAILMQRLVKVDGKVRTDMTYPAGFMDVITIEKTGEHFRLVYDTKGRFTVHRIQDEEAKYKLGKVKRVQLGKGGIPFLVTHDARTIRYPDPSIKVNDTVKIDIETGKIQDFIKFDTGAIAMVTGGRNMGRVGVITHRERHDGGFNIVHLKDAIDNSFATRESNVFVIGSEKPWVSLPKGKGVKLTISEERDRRRATTIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Q1</accession>
    <name>A0AAE0U7Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_19188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041924154" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="12572" checksum="38F4ADF8D1D2884D" modified="2024-05-29" version="1">MLSVLYALALLGLTRSEKKFLQTRFIRHSARQAIVHPPSQLHLPLTAVFPFTNISPTLATVSLPPNCLLVDSRFVTITPPLTSTSLAKASACSCSRPLTLHAQSKPILFDGRHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7S4</accession>
    <name>A0AAE0U7S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_460174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="205" mass="22532" checksum="409081BFCDBFAE6E" modified="2024-05-29" version="1">MSSPFSINGGACVAMVGKDCVAIACDLRLGLQALTVSNNFPKIFQYGDVFLGLTGLATDLATVSDLFRYKVNMYRLREERNIAPTTFANLVSSTLYEKRFGPYFVSPVVAGLDPKTGKPFICGFDSIGCIDFAQDFIVSGTATDQLFGMCESLWEPNLEPEDLFETISQSLLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7T8</accession>
    <name>A0AAE0U7T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_458694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7T8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3393639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="345" mass="38229" checksum="276FE6DC8C494D99" modified="2024-05-29" version="1">MVRYSKLAFRQTVFEYGTDLCWTPMILAKEFNRNNFARDSDFTLSTHGTQPPTIVQFGASLPLELARASSLAAPFCSGVDLNCGCPQSWACAETLGAALMEKRELVRDMVVETRERLRQDGWDVGKEKDMNSPKGRSVSVKIRVHKDLRKTMDFITTVLGPDQDRHIDFLTIHPRTKSTPSSTPINIEALEILTSTFGDRVPILVSGDVFTLNALPFTSPLFPPTFTSSSTETEQPPPTPLVNIPKLAGLMSARAILANPALYAGFDACPWEAVETFMNKVARAPLPFKLVQHHLSEMCSPGLGPNKRALLTRSERSAMMSCQNMVDLIDFLDEKGNISRRTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JWQ2</accession>
    <name>A0AAE0JWQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-glycosylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_490899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000022">
        <property type="protein sequence ID" value="KAK3365422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JWQ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3365422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="47774" checksum="CD7FCF891DECED87" modified="2024-05-29" version="1">MSNRARATAPRRVADNSSSNDNNGLLDHSPYPNNSSNLKSTSTSSTLASRRASNHHNSHTPTKQQLDGNHAATQGGHVSSHDGATDASSFTNGPGGGGADSDDDPSAATAHSSMLQPRVAVVLGVAKTWHPLLFACRLLSIVPAIWWGLPIALRLLAMIRMIFFGWGVEGSPASSCTSNNKGFLLATAINCHELPFEARLRLTETLLATIWCGASGYLSFFFTDCLMSRWYASPPPAPKLHPQATLVRLLTTSALNGYLSSWVLFITGGSEDPRLLLPAWIGISTTLTVMYHVTQRKINIRKETSIMVALLAQLHSNRSDYPNIPLVTFTRRAIHEAGKLALSIWIEATWSSVTWRHKASWAQKPWTYANASVFGYAVDTSHQRHRAYLNGLLIEGKTFGLVGEEFLDLGALIALELDHLAHALRVFVANDGAIASCEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZK5</accession>
    <name>A0AAE0JZK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_405418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZK5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="21003" checksum="5ACAD9AF070DEFBA" modified="2024-05-29" version="1">MTSTTSLSPSIINYRERHGRTYSNYEDVEDWYPNDEKQQGSLEIMHQMMLIYDKGKLFQAPVENPQRLLDVGTGTGIWAVDFASRFHSASVTGTDLSPIQPEWVPPNCSFELDNANLRWNFPDNEFDFVHVRGLTGSITDWEEFYRAAYRCIKPGGWIDVGHEKLFLRKVMEVVSEENRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0N4</accession>
    <name>A0AAE0K0N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase Family 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_423905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0N4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35670" checksum="AACA5BE6958DE055" modified="2024-05-29" version="1">MLFPHRPLVASNASRSIAFVSALLAILFFFVVLYRSWGAGRNLSSFGGRLGLGKPEPPTTIPKKLWYKLGPKGLSDEARAWTDTCIRNNTDYRVEFMTEEAADVYVQAAFGMRHPKLVEVYLGLSIPILKADLLRYLLLFAEGGVYNDLDVTCDAPIDDWIPAQYKDSTAVVVGWEFDVGWGDNFIREFATWTIMAKPGSPHIWQVIEDTVEFFEKKVKENNVPLGKLTLDMTGDVVDATGPRRFTNGLFKSMEKIYGARASIEHVMELMEPKLLGDVLVLPGFSFAAGSNTYDEGVVLPPPLVTHHYAGTWKNKNGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0P3</accession>
    <name>A0AAE0K0P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_529251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0P3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="708" mass="76946" checksum="D1C25C6C0536EB98" modified="2024-05-29" version="1">MPSTTTKASAAVAAAADNSNGTNSNTNANGTPAPAKRPRQSSGPACQQCRLRKLRCDRQMPCGACVDTGVACHVDPTTPQRGPKRGHLKVLRSRIAALERHIGKSDPGGVDGLDLDNISSSGGHESDSPRGVSPVAFSGVTAVSIPATAALDLSLPDAVPPTSLQQHLVHLEHHRPSIGGVVVPQVAPPPPATLQTINPAQLPLIDDGGIRGSGGASYHHHQIDHQALGWPATTTTGEDAQLIPSLTRADLDQLYFDRVHVFMPVLQQCRYYNRSSKPSSPTSSHRNSFSSTHYASSTSFSTASHECLQYAMWAMAASLSSQFQHLRCMLYREVLERLKALELASHSLSAEDEATSRLEQAQAWILVAIYELMQVGFHRAWASAGRAIRLVQLLRLNEVDYYSSHADGSEDAPDVFVEKEVKRRTFWMALCLDRFSCVLGGLPLTLSEQGISTRLPCPEDAFQSGTPMVMPFLPEVMVLDNQCKLSPFAECVVFTMLWGQVLVHKQQAAAATEYAYSGSSNTTNSHPTPADFCKRQLWLDSILSRRMLHLQQNYRAASIRVDSMLLLTSMVAQSALLLLCKAVESVPPTAAEYGELIDRFAGREAAGVKEIARLSKFLTHFSIFKVHPFTPISLFLCQQSILSLRDRDASLEDDLGTITDALRELKAVNGLCQEGLDMSSCGFSDFDPPGLLGTPDSLMAFLDSEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1M3</accession>
    <name>A0AAE0K1M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_88100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1M3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042093834" evidence="2">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="162" mass="17580" checksum="7303E30842593190" modified="2024-05-29" version="1">MSLLVFHIFIAIVINQGNIVVMIVGQPGFNRNFSLRHPARHITPELVKSRHYDASFLSPRGRLHGGQDSRGRSPPVAEMPLPPKHPALPIPFQLGMKSVLAPPCPSGDKKEETNPGRHNSEYTGAQFSHSCGVVSACVEPRVQAPAGRDPRSPGSASRCHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K291</accession>
    <name>A0AAE0K291_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_73652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K291"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="329"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3368242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="710" mass="80181" checksum="D99BC4C07812D51F" modified="2024-05-29" version="1">MSTPTTATATLPHYNHPHHFAYSHHQYPASNTSPYRTNNPILPTASRLAFPSSVGYPAGSNGIGLISSEASSRPLPQEPVNLPARSDTTYTAMPPLLQAQIQPTPPSQSQSQSQSTRKRRRSRDKVDWETFYKNGLPSEIIVIDDTPEPERPGAASVSSQPLTNGHANGATNDVSARHLAKKRKRDDETAHYDPVHNNVAGSLAHTPRHHGSPSKSTVSTDRTNSAIHTTAATSLGSLSSNSQYDYSTQPGQKRKRTTRQQIANEAARQREQGALMDAFSYHRPPQPPKKASEVHVKVITDNSHNKTARCDDEDGHYIVVPDNDLTDRYQMIRLLGQGTFGKVVQARDKRRNKFVAIKIIRSVQKYRDASKIELRVLATLKANDEENRNRCIHLRDCFDYKGHICIVMDLLGQSVFDFLKSNSFVPFPNSQIQNFARQLFTSVAFLHDLNLIHTDLKPENILLCHNDYQTFTYNRKIPSSSSTISRQATQRKVLLDTEIRLIDFGSATFQDEYHSSVVSTRHYRAPEIILGLGWSYPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEMVVASKVDPNLITQVNRNPRNGGNPAAKYFKRLKLDYPTNETTRASRRFVKAMKRLDEIIPTTNKFLQLFLDLLKKIFVYDPSQRITAHQALKHDWFKECAHQDDGTEAARIRAEKNRQQELEGSVSSHATVLEERGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2A5</accession>
    <name>A0AAE0K2A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2A5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="85" mass="9496" checksum="570A3B474742099D" modified="2024-05-29" version="1">MSVHSASAMDTTPSRAPRYVQPEVGGDAYLLSQDLPGPRIRLDKLSAKLRTKFGPGTYKIYLIHDVYSIKVPARLSLTEIAECFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2K0</accession>
    <name>A0AAE0K2K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_488002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2K0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="322" mass="36306" checksum="FA201BB6F594200D" modified="2024-05-29" version="1">MLASLVARPSHLLDVELIDKDLDGVALNSSPIELARSISKNQTFGQHTQDMNSPRLLRPLRPLLHAQLTVSTPRTAQIPFLRPTTTQLRTNASIASEPPSSAPSPTPVSKASTPMRKAAKKVVQKKKTAVAKKEENENDGPRMPRSLEALYLKPLRRVAQYGVPSCDLQLRSYSVRNLEFFADFALRAAYYLGLPAYGPVPLPRMTERWTVPKSSFIFKKSQENFERITLRRLIQIRDGHPESVQAWLAFLQKHQYYGVGMKANMWEFSKLDVAKTMDESVAEVSTLLEDKWNHLGHDKDMKGVKDIEEFLATERLKASGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2L4</accession>
    <name>A0AAE0K2L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20565" checksum="3F19627A807CCFBE" modified="2024-05-29" version="1">MTVTEEDGDDVDSSLSDAKKAKKERKERRKERRERKEKRREKGWKEKASSDSESEADDSISREKKRRKSKGDKSAASTPLESSTFTPGGSGTSTPVPTSIRFLSRQKYIAQKRMAFADPAALNELCLTDHGVNAANALLRQSSGPASQVFEVGKKHGVGLLDDFYMTLGHGPRPSEVLVGFNWHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2M3</accession>
    <name>A0AAE0K2M3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_534362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2M3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="410" mass="44334" checksum="E7950403F39290EF" modified="2024-05-29" version="1">MSVDTHDPTKDESEDSMESSPEGEEAPPTTTTQENQQPKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEEAIRTHEQNLANLQAAHRHAADECLMLRYKNSLLERILLEKGIDVQAELRAKTGSPNLGPTHMPQNMVQPPTIQRALLNRHHSRRSNSSIAPKLEPGAVSPLPPPISSHHSSAASPKSRPTPSSHSASPTATASFGSQHGASPVGSDHMTSMRQPLPPTNTMKAPPHPQGIAGMAGPRQMHMAALQQQAAAQARAGVGRTPASFYPTPSFQNHIEQLGKLTRSSRVSEQEYDAAADMMDDDAPDTPSGPGPYPGAPYCGEQQSMALASPVSTGPPGSQQLSGHSPMGNIPNPQHAGYPSMTQLLDPGFEFDPFGLSASMAFPTQFSFDTSNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K332</accession>
    <name>A0AAE0K332_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_534826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K332"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="441"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="784" mass="85786" checksum="C64E61B4FECAB85E" modified="2024-05-29" version="1" fragment="single">RVAGFSFGRGTLLLQISLLLQSFRRRRRCSNMRTILDIVVLGSCRTNAILILSDSESEGDLTMADLVQVCERLDTISNNNDVSEPPVNSGPGPDDEFADEQQQRGSRKPSPEPLSSSPKTLHARWTQPIPSNYYNTLRDTAVTDATSLVEHKATCHGHEMQHGPRPSENPCGKTSNHDGSICLDNEEWDMRFPFSSEALRRKNTAKSASQGPRLAASGLGFESQRQSDSHCLSQHYDREEQDGMCPAALPQVVESQGRTPTLPDVESTSELGPADAEPRLRPQSLCDAASGRGVNPQLRSGSCRLSQYRDHHDNSDMANDGEERHPLVPDGREQDKDETPAPQDRRAAYNSISEKTTQQQGNPALAAEASPVKPAGIPLTPGTGITLKLPDKEEVSLQQNIGHRNDDTAEKEGCLPIVGNDAKQGKDEDVVQPPQGKRRKTCEVKCSAAAFDTADRQNAHSMTLAVRGIVELFRAVKREDDVNGKILAFSVSHDHHRSVRIYGHYPVITRKDIKYYRHPIHTFDFTALDGKDKWTAYRFTNISPDSQLAATTAALAFSTWHVCENDVVAADGTGGVGVGIARGFVVRWAVIVPVMVEESFDSVGLDSEYTDDGNLEVAILRNGLGCYDDQVAAREVARSKWLDTTIAFKGHPYILIPPALCIDGFQNRGTVLVNGMLWIAKVLVYDTHSVPGAVRDADMENMPNIPALEEDDDIVRRPFGVIPVLLESIFNGVLDGLEEDVWVAVAEDLCSVLGMTVLEAACRCGDSKRLTIQPGDGDSANGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K565</accession>
    <name>A0AAE0K565_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Marvel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_314394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K565"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3370314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="18287" checksum="BB430F25DDFA4293" modified="2024-05-29" version="1">MDPMQLLLRGLQLLWIVLLTALIGNVIVLNINGAMAAINFSMFVIVVSWLACLFGLFVALVQRFDIPGKALFIADIVASLFTFIGAVVLAAKLRAVNCADTADWGEGWIAYGSLNDTKRCREIQASAVFMWFLFGTFVAGLVLSWLGFRRSGGSVMSAGPSMSQFRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K650</accession>
    <name>A0AAE0K650_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_503899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K650"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3370156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="524" mass="59796" checksum="DB2FE92FB870319A" modified="2024-05-29" version="1">MRLIPLFSALVPLGEQFPVDSYYKLPAYVPKKVSIPRIQKHPAPVEDEAARHIRETRQAAVRESFLHSWNGYKKNAWLSYEVLPLTGKRKDTYNGWAATLIDALDTLWILDLKGEFMQAVRAVAPIDFTTPTHDEINVFETTTRYLGGLLSAYEISGKEHRILLEKAVELAEMLLGAFDTLNRVPISRWNWKDLSFEFTKLSQLTKNMNFYDAVQRIANELELSQNSTLLPGLWPVAVNYFPKQYLLLGGAFQQPKQMYERFIDVAKRHLFRRVLNPANFPVIVSGDVYVSTQHLICFVGGMVGLSARIFDRPQDLDVAMQLTDSCVWAYNATASGIGPEGYTLAPCASIDDQWANKKCTYTDWKWRKALQAHWGDSGPRPEDQRGPPPNEQETASGQKITAIIRGERLPPGFIEISARGYKLRPEAIKSVFCMYRLTDDPAWMGKAWQMFVNVGKHTRTETAAAQLLDATLLELIKEDRMESFWFAETLKYSYLAFSDWDTVNLDEWVLNTEAHPLRRADAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8X8</accession>
    <name>A0AAE0K8X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_563745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002468">
        <property type="entry name" value="Suppressor of ascus dominance 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="120"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="314"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="631"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="707"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145452" checksum="CF087684D14ECA37" modified="2024-05-29" version="1">MLIICIRTAATNLVDTGTMRDSSAVGVKPLEIVKKHVFFDPGKNKGWQSRPELPESSEILAAQAATEELPENPVDKAWESKAAYLEAHYKILRREGYEGLRYSVTEYKKSVKQGKEMIDDDHTCVYTHVHVKTYLFTQLGPIVRVEFSTRQSRYQIKWQQSKRLTPGTIVAITTKADNFGKICKIATVAQRPYRDGLDQDPPLVDLMWANPEDAVFDPDLELVMIESRNGYFESARHALVGLQHAAQTESPLDKYLIGAYTRDTPPSFVLEQPEMDFRSIAHHVVEGDLDSLRPLRSHNVLTEGITYLKDMTTLDESQLEGLRQIVASELAIVQGPPGTGKTFTSVQAIKVILATRQKFGGPPLIVAAQTNHALDQLLTHCLDAGANILRVGGRTESPRVEACTVYETRQRYKETADPQHKAFSNTRRTIINAIQELVSSIFGDRLLSPAALLDAGIVSQAQHDSLFDDTMDTNQEDLERGPLSLWLGNNLIEAHLLRNKHKSWPQREEAEAKMVLGEFEFDGDLDNIADDEEDQDRIYGTLVGLAHKWSGKEPADSSSWGRAVARQLAENDDLFEIDHDLRGVVYQYFQAELLAALTPKFTTLLARYVEICKQIKANKWDRDTQLVKMGRIEVVGCTTTGLTKYRGFLAALKPRSLLIEEAAETREANITSAIYPSLQQLILVGDHQQLAPQCDIRWLGDEPFNLNISLFQRMVNLKMPFVMLKQQRRMKPELRYILSPFYPELEDHPVVLSYENRPDVPGMGGRNCFFFDHAWPEKIDSDQSKKNEQEAQMITHFFAYLVANDVPASKITVLTFYNGQRKLVLSNLKRYPTLIGYQFKVCTVDSYQGEENDMVLLSLVRSPQPERGFDVGFLEDQRRAVVAISRARRGFYMFGNVENMLRAHMGSYKLWGRIWNGFAEQGRVQRKKGLPIVCQKHQKELWIREVDDWGDNAGGCDMLCKEMRSCGHLCTLKCHHLPHDQLLCSQACHKILGCGHGCEGFCNQQCSCSCPEFRRIRIQSDAASARLSEAIAGNKMTFEEKLLKSGASKSLIQANMSSRGLSSIMRNTSDPQDRGSQMGGKPLDVQSFEAWQHFTSNVQAHDESLRQQRLTLSSTLTSPDGTNSGSSTPVIKDIYQPTTLVQGRRTGNGAKSMQLQSSRPQTPNKSGQSAQDPGTNIGMSALTTLLPIRPAANPAGERRGTTNPSSGVSALPTMLPIRPVVSPTVKSHGTTNPNTGLSAMTTLRPIRLAATPAVESYGTYNPNSGVSAQTQSPNPHKSVQGRSPAKPPTIPQDDDEEWLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8Z9</accession>
    <name>A0AAE0K8Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_496859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="111"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="541"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="714" mass="75510" checksum="31800E83A2429C9F" modified="2024-05-29" version="1">MVAEDDTNNDGEEDNEEEEDQDEQEEPEPEPEPEPEPEPEPDQDAKAQRDGESQVPRPDGDGDGDGDGDQPGDQDPTTANRPSTTPSTPHPLTASQWRPRLRQEYITAPLYDIVPTMAAPQATNVNCIAMTPDLRYWLTGGSDCYIRKYDGMGTINGKQQLTVAQRHPFVDSVVKAGILMGYWGNEEPPPASARTGQLSPVYSLAVESKALWLLSGLESGGIRLQSVRHDEGKMIACLHDGGHTNAVSVLQLAPDERSVLSGSWDKSVLDWDLDTGHVIRRFDGSGGQISAIELRPANGAPIPAEASDPEIVKTDTFESNNQKPPLSTLFGSGPAEVASAVSGQDTGGVDAAAAGADAASPEHESLFGSPARSLFGDNDTMGGGGGGGGAFGNDEDDEFSRGLDMGTLNDESTHHGLDNPGEFPMGDMDLSGGPGDLGSAPSGAPLPATEAESSGNPDDSNTLSEGTMHNGGTTQDTVMEFSQLPSETQQPPSSAEPQPAPGLEAPNAPVVNAFQPAIAQPAIIYASTAPNAHHDPTQASTSTFLSAGIDGTIRIWDRRVPDPVARIGNRHGVPPWCMGACWSPDGNWIYVGRRNGTVDEFNIHNASSGWQPERVLKFPNGSGAVSAVRAMVNGRHLVCASHDIIRLYDLRENAAFRHSKVPFVIIPGPPRAGVISSLYIDPTSRIMISAAGTRGWDGTSTECIIGYEINVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K986</accession>
    <name>A0AAE0K986_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_294506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K986"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="298" mass="32165" checksum="434C7F99BF185540" modified="2024-05-29" version="1">MLSDECEKAQDIGRLVQTTPACCLVPGVGPEGSQRDFSQPPGFFLQPSGTSFTQKTWPTRSFQTPDAPGRKGGLQTENHNTLNKNKQQPHPKSVLAAHRYLPQKTGQKWPHTPPKRGWTFWRLVELTEPRDPFCWAATRTPLPRLASLSLPVAPCRVQGSRRISALLGSHVRDVSCTPPYFLSARFPWEKNSVPSIGKGAGGSGIWLAGWLLAGIAGAPWAAGLTGGGGATPAWKMWSASSFPLDGLLTSRGSRDGFMDDGCSGADVPCTLYLPPFNSFRSPTPSGPLKNTLPTEVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAM2</accession>
    <name>A0AAE0KAM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily transporter monocarboxylate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_564109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAM2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="49520" checksum="FE489A4A11632E51" modified="2024-05-29" version="1">MATVAPRTANGVANDPPDFSDAPTATTLTDTDDTTRPTDHTGIKTTDDADVPTSEKPAAPPQKLPAPNGGVLAWIQVAASFCIFFNTWGVLNTFGVFQTYYESGALFQESSSNISWIGAMQAYCVLVVGLASGPIYDRGYFRALLVTGSFLIVFGFMMLSICTTYWQALLAQGFCVGIGAGLIFVPSLAVLPAYFSTRLGLAIGLAASGSSLGGIIYPFVFYRLLGQVGFPWAVRAVAFIALGTLLIPSALMRMGFRPPKPRAVLDWDAFTDWPFALFTVIATIGFIGLYVMLFYVSYFAFATGIAGADMAFYLVPILNAASMFGRTLPNALADKTGPFNLLAPGAIICGALTYSLIGVRSLGGVVVVTFLYGFFSGVFIALPPLCFFQLTADKSKMGTRMGMGFACLGFGVLIGGPGGGRILGTDLDDLHWTKLWAFGGSASMASGLLLCALRLYLSKGKLWVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KB81</accession>
    <name>A0AAE0KB81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_302852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KB81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042208409" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26872" checksum="8EB7AE2780D99164" modified="2024-05-29" version="1">MPRRSHDFSSWHLCIFCTMCALFAPFCTPFCTGNTSKPHLGPPPLANRLGTSTPLDRTCVAPDSRRHSRPITIRVLHHSVFCVENAVLQRQPCEGTPSRRPKWRRLLTNTRIGLMEGREGGTETDDCMWASRRTSKYRHELPGSFIPKESITPTFLRSNPLHECSPFTILSPIVSFRGDVQTWRLDWTRSHPHVMIGGRTSSRFIHPQVSAHKVTACTASLSWQTPNLDGNFNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDQ6</accession>
    <name>A0AAE0KDQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_549020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDQ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041936975" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="14"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="287" mass="31603" checksum="E43BCDC0C0629E5C" modified="2024-05-29" version="1">MVQVTVLTSFAVLAATAWASIPALSGYSVVWSEDFNGASGDPVSNANWDQMVRSRFKNDNNEEQEYVGTSDVAHLSGDGQLYIIPKKQAAGYFTSARLSSKATFHCPIGKALVIQAEIRVPDFTNAPAQYAGLWPAFWTLGQSIRVAGGNGWPKCGEFDILEVATTLTNKNQGTLHYEWTNGQHRSSSNQIIYSGGDYHTWAIKIDRRNSDWTQQTLTWYRDGTAFHTVTGGQINDFSVWELLAYKSHFVILNMAVGGNFSGPPTSNTLGGFDSSMRVRYVAAYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDT1</accession>
    <name>A0AAE0KDT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rdx family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_562985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDT1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="295" mass="32651" checksum="98F6770AAECFD084" modified="2024-05-29" version="1">MTHIRLHPPHIGVHLRRLVLESKSPIPSLERLLAYLPTYCRTSIHPSTTNDIPLSVKIWGGVRSINPFPCGSFESTAIDLSMTEPATATAVAAAEPPRLPRVTIQYCTQCKWLLRAAYFAQELLSTFSTALGEVALQPMTGGVFIVEIAYAATITQPQTSSSDEPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQRHSAVLWDRKTDGGFPETKELKRRVRDAIQPGRDLGHVDHDYNRNNNNNTNTTSSNKAPPADAASTTTAAATTTNSSTTATTAKVGLEEGIKCEDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KED8</accession>
    <name>A0AAE0KED8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KED8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="316" mass="35033" checksum="E8F3B411CCBE5D63" modified="2024-05-29" version="1">MPGIRQNLTFQTLALLKRDDKLLRRIKLMDVGLEIKKRHDAQRVDSLGAAGFAFFPERRNDGNEKDSDSNMPSAITLSDVSNLSALTIPISPKELADSSCHYKPDTVAVTTTTEAPKIHVERSKTQDTPTVLVIRTSPTTTTFGSGSGEKTTVLPPNPRGLPDLSSSCDAVFQLPQVTESVMAEFFRRAVSVSKARFAKLFSDRMAAEAAAESGHGTDATGRRTNNTEKLRQLSLGQLKELCVDVYDELVRRNKVDSYGQTSVPVALLPVKELAEQRNQARTRLSRLNDGYFFNLIWDCYRELEQRGKGILDPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEI1</accession>
    <name>A0AAE0KEI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_452870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEI1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="486" mass="54445" checksum="60D34BA09B705EF5" modified="2024-05-29" version="1">MVLFFSPAAICLVLSIGLLVGDVVVRRALLSPLNKIPGPRHARFTSLVLVWHEFRAGRTAYIHRLHQRYGPAVRVGPNEVVFASAAAVKEIYCSGGSGYDKTPFYDIFKVYGRRTMFTTLNKDDHAKKKRVLADRYANTNVVRQPSLDGIAQRATNFVKRCFGSVGGSLDLYIYLHSYAFDCVTHHLFHPHGTDSLNSQHDEEIMREVTFDDSLQNRLVGYYSPTLHKMFGKILYWFAKPRETPLADGFVLGTSAKTDAASFTLLNRLQEPGSKHDSLDIAAECLDHMAAGIDTTGDALCFLMWELSQPASFQYQTKLREELLANPGAPFDKLPYLDAVVMEGLRCFPPIPMSLPRYVPRGGRVIDGYSVPEGTIVSCQAYSVQKTDHNVFPNPDDFSPDRWLEPTGDAERKRLFFAFANGGRGCVGKHLALAEMKLLLQAVYSKFTTRPDDKMTAESMEMSDQLISSRPRGQRCLLRFDPLSPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KIX9</accession>
    <name>A0AAE0KIX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_220111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KIX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169385" description="cellulase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="57"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3377529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="42234" checksum="47EEE8907380E85E" modified="2024-05-29" version="1">MKISLSTTAAAALALMLSSHHVSATIYYAGVAESSGEFGAWSPTAQVGTGLPGRFGVDYAFISNSGVDVMADQHKVNLFRVAFLLERMCPLAWGLGARFNETHFDHFKQAIDYITKTKGAYAILDPHNYMRYNNPSSQPFSGSVIGNASDPTAATTAQFGAFWGELAKRFASNEKVIFGLMNEPHDMPSALLLANLQAAVDGIRGPTANAKNLIITPGNSWSGGHAWTQGGDEASSNWIHKLVDPLNNTAVDIHEYLDQDYSGGHLACTQDAASNLAGVTAWLKEHKLKAFITEFGGSNTTECKTMLSGMLDYMAQNEEYIGWTAWAAGPFWGPNSPCCTDQAQFGSLEPGSKAADGGPGLYDTVWVPVIQKKVPAKLQWSGPASVNGGPLTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ52</accession>
    <name>A0AAE0KJ52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_221614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ52"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="842" mass="94685" checksum="D7982F6DB6FE5FC7" modified="2024-05-29" version="1">MSAPPPAIPYGRKIPSSEERHERRRKAAQNFGNFVVEPIDDVPAIGKKATKAREHAWRAFGDYSKLMDIGNPDEIWIGLCYDSEAAQAHCRAFLTDYVEYSTTRQPCLGPKEHELVRTVNSTRTVLSLWKALILKADLVVLQKKREDARSSRIVPAFRADGSRVTWKLRWDRGDQGRGSGPVYNISNWICTDLTDKFGLSRFQMFVKQATRAEDVIVLLGGLWGRPQDIPCDPRTRLAFHSLVLLATIGGFRPDTLVNLPYSQVQLVLVRDPNYPQKTRLVATFTIHQNKQRTKHVHTNQTETISFAITFIPGQIICLLSLTVGQALIDEAFLDAFGLGFDLSSLTDALNRPIEDGVNCVELPWKPDMENKPIFPLSYARFWELWNLTVLVVGNRGKLLLYSLRVGAATTLNGALEPAARNYIMSQSTKIHESNYQARYLKENLQEIAFGDEAGENSALFNTLRFVTLKRDENAPLYPTQDELNGFEERGDMRAFRAHYEEVKAMYSSCCVEAKRIAARIFHLRRVLSGLVVQARRIEYFKQVDMRRARGLPTTDLRADASGKPYKKVFFATQLPAALRIAEFLSQRDLREGRMLFYIELLVNYTQYLSGTTDLPTTDLPTTDFPTTDFPTTDFPTTGLSTTGTKGTEEIRCLLCGSPSSHRGNLTKHNLNAHISKGAFDKPFSCPECRRLGREDFIVSGGASAWSNHVERCHGGKAHAPNVPHPAETVLQNTKTPCFLCDGSYMSGSGFSRHFRTTHATSSIFDIPFPCPECRGGNKEDIMIDNLSIWHLHESEVHGRNGNTGVLLLRDRAGSKRKRSSSRDEKRPKKIKEGASDVDDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKR2</accession>
    <name>A0AAE0KKR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_228845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKR2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000466">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="456" mass="48525" checksum="BBF67E787B5FFC8B" modified="2024-05-29" version="1">MRDGATGRSRGFGFLTFKDPKTVNIVMVKEHYLDGKIIDPKRAIPRDEQEKTSKIFVGGVSQDTTDHEFREYFAQFGRVVDATLMMDKDTGRPRGFGFVTFESEAGVEACLSTDLEIHGKPIEVKKAQPRGNMREEEEAARRGGSAGGKFGRKGQAGGNGTGADDGSGGGQNAMGAMGGAAAGMTPQLMAQYMQRMQQAFVVMQQQMAMNRNMNPAMMQMMQMQQMQQMQQAMMAAQQGRGGGPQAANAMGAMGNMNPAMMQQMMNQGGGSMSPVGMGGQGAQGAAGQASGANRPAYNAFEQQQFEQQKYDRRGNRDPQQQQQQQQQQQQQQNYNQQAAYNMSGGAASGGAPTSWEGMYDDVPQPIMTGGGGSNYGGGSQGGSQSGGNGQRGFQKQRGAHHQQHQLSPSPVDPANAPPANAPTGPKNAGKPYANYRGGGRGGSGNSNRGFHPYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL17</accession>
    <name>A0AAE0KL17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_479022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042160834" evidence="4">
        <location>
            <begin position="35"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="41049" checksum="38C7EA01D698F389" modified="2024-05-29" version="1">MDNTATHNSPRTWFLTSSLSPLCIRLIRLLLAHGDYVVACLPPHELEHDERSAEFRELVNECKSNRKDREGWKDRIRGIRCDGRVMGQCGAAIAEAVQVFGRIDILLCCKFEAVVGTVEELGASPKTRNLVRDQFETIFFSQVNFIKAALPQFRAQHTGHIIILTSIGGHIGTPGMSVYTAATWALEGYCDSLAYEIAPFNIKVTIVQPNKEIQSLTNKVILAPQLPAAYYYSDDGGDGGSSSGNQPPAAPSMRDMMTNVLNSNPETAVEPSEDEIQSRYPRLPAAALDKLVMETVHALTAIGGHENPPARHIVGFEGSIAVREKLKTVTEEMEDFVEASLAVDIFESELKAEAREGRYLMDTHMGGMGSVSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N280</accession>
    <name>A0AAE0N280_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_514862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N280"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="40384" checksum="63426E62E4F500B6" modified="2024-05-29" version="1">MLWKFRCFSKNMATLGNLQRYKEATRLVYGPVDDLSEEAARAWTPPDNPGAGGHRGRYLWTDAFGVVNFITLSKETKSPVYLTLAKRLASTVHDVLGTTRDGTARLHRATDLEPLGGGLRIGKIDEHGSDGDGQYHHYLTLWMFALNRLSLATGEKEYNQLAVQLAKAIHPHFVIRKEGHEPRMCTCRLKDISMRQLGVLSVEIADYRLLMNREGKLRSSSDPLDLGMGLWMCHFFRDEDWARFLGSQSLEVARIILDDKHGLPARDFSRRLSFREFGVCLGLQCFGIDEELTARVAAVIDFWQSYINDSAEEDLRPISLVMYAAALVPGAFRDGCCLASSWKLRPTVPTLMMDPMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Z5</accession>
    <name>A0AAE0N2Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">B0H63DRAFT_73182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Z5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3368233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="167" mass="18549" checksum="C2B6701B8A18CDFB" modified="2024-05-29" version="1">MAPVNTDHQVLLEKINRILADIFQILAQIQNYDQGGRPSREALVHDLQTLDASLLAVYTTASATLDTSARIPDELIRYVENGRNPDIYTREFVELVRRLNQTSRGKSNAFRSFRDVLAHEMEVAMPELRDDIRRVINETGGPTPAAPQTGHAGVMTGPAGAPEQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N349</accession>
    <name>A0AAE0N349_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_489620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N349"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056073">
        <property type="entry name" value="DUF7656"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24676">
        <property type="entry name" value="DUF7656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7656" evidence="2">
        <location>
            <begin position="384"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8206" evidence="3">
        <location>
            <begin position="932"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138783" checksum="6F4CF19E4972F560" modified="2024-05-29" version="1">MLKRPALGQGASLGRLYDARKDDFVPLSLLKAAPPDGAIAATDIPSSDIKYTRSDSFKEKFHQLDVGPGLSASFLAGFFNVDGSGSYLNEKRDTNLAVHASLIYNVTTVNEVINFLAPGMEDCLALDVLESDLATHVVAEIAWGSRNVVTIKQSLSQRQSARKVSARLNAQISLLGSKLSGGGQGDKISGSQDLDNSFEVVMCADVMATDGCLPTDLSGAAHFLKSVPKYVANANGGKGKPLSYTLLPVAEVAARLKFQISRAFTLKQLSLDCSENFVRIFDEMAIVRRDLNDYRATLLEHREYISQAHIRTIGDRVVEARTAETQLKAKYAGALIDVRSGKSDESLLWKILEDFTKGETATRRLAETNSRPQKEKIALIQGLIAKGAMYIGFNGESFDLAMGSSPNLDIYVLYLSDEARRNSSVWQQNTSLIHQLLDDQTRQSQVIVKDCDALDEPLPKPRIALFRNAEEIIDDVLEDRKASSSKCGARYIKAHLDRSGAPKPPSRIPIKMPCPGPNCSISTSHEWICAKCNCPIEYGHVDEYIYCDCGRCDYRHWTFRCSNQRHGLDYHVFADARLKGILSALEPFEELNILILGRTGVGKSTWINAFVNYLMFPSLDDALNDNQKLQWIIPFAFRTYNLNAQDEFEDVKIKVGFEDPRSPNGGSDATKVGVDEHDGTAGGSATQKTAVHRVQIGKMLIRLIDTPGIGDTRGASQDSKNMADILSVLRSYQNIHGILILLKPNDQRLDLMFKFCIQELLTHLHRDAAKNIAFGFTNTRGTNYRPGDTFDPLRELLQRFEDVEITLRKHNVYCFDSESFRYLAARKQQNQMLGELEENKASWNYSVKESRRLIDYFQSLPPHKVTSTVNLYETRHRIVRMTEPMAAIAETIRATIMVNKDEINDLSQSETKKKDLEKILRIEVKTLTAVRVSMPKTTCSDESCIERSSTGIEGLDGREILKTVYKSMCHSPCYLNNVQLDNIGDRGLRGCWAMNGTEYCRICGHPWNSHLHINWEIQHGTKEINDPEVEAALRLNADFRTKKQAAISGKKRLIADLESELKKIGDAAAQFSIFLKRNAIMPYNDATIDYLERCMEEEKGKVAVGGSRDKLDSLTQYRRQYEQQVAILVEYMKKGEDHMLLNQAGIEILLQELHDLKHYGQTLRDMGRVIHSSQTVVHREKPFVMRARSHWTGGEEEPEYATVSRSTTAAKMAEESARARGRTKSWKERLWQAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3N4</accession>
    <name>A0AAE0N3N4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_488024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3N4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="82" mass="8768" checksum="08956340FBA84EA6" modified="2024-05-29" version="1">MPRGLLCYLACPWLSEGAPADRRACSVIDEVAEHVAAHVAYDGRQVACINVGLRPPSFTLLTLSNLLSSPPLAPAWLSHITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3Y8</accession>
    <name>A0AAE0N3Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3Y8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005710" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="155" mass="16399" checksum="E53A1F99DDBD1661" modified="2024-05-29" version="1">MKLSIIAILASIALTHGFKFETKPADGDYVIEKDASGKEVATFVGALNTTEAANVGPMDTKSTIRGRGNLVARDQVGCTERIMNSGDTNAAVNSLKNYCGNGRSYYNAKMAFVSGGILAYTCDYRGGQLCYASEAAFAYQLITNSCGGYKSGCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N400</accession>
    <name>A0AAE0N400_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_564240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N400"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="261" mass="29099" checksum="CB13F304FDBEA29A" modified="2024-05-29" version="1">MGPKYSPKHPRIDTELEPIYERSREATRTASEITQNLSDEESASKAEVGKTELRTSTVQPLIRSRFLSTPTSRKTILDRSAKQLAALYELGRIVKDELVPTASVLAENFELQHARELELILDKTATILDMLDTTIDNLSDDSVHHSLDEVVDDIAIYIDCLMDLSPALENPVIDFQPTNPPPKEKEAVDVCEVSPTVPTQDEEDRLDDSGSESEDQVDFSDTNDDGKTGFSHQSEEWDNSPKVLAIESCYELGLVYCGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N433</accession>
    <name>A0AAE0N433_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_486012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N433"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="93" mass="10459" checksum="7D183B33C88D0A6C" modified="2024-05-29" version="1">MYVSGNNEGEPWPSSSAHASLAGPVDLDTFRIKEDVWPEALSKTSMFIKLGNYLLPENDRPPHKGVHPWAEGAAGEHRIPNTWHYQVFTSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4G5</accession>
    <name>A0AAE0N4G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_440169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4G5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3369885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="34921" checksum="B793BD4DFFDD66A8" modified="2024-05-29" version="1">MFGTFGYHLPRIASLLARHGADIDFHRAGSGMTPLRYAAQRGNLIMVKTLTGMGANLTIEGPLGIQAIHAAVQFGHSEVVRFFLDEAGLDSQVEASHFDERALKRDNSCNLLHFAAMGDGGVGMIDLLAGRGLDPLSTSANSKSPLYYAISNQNLALVQHLHSKGANIVPALLDTAETESLGDLLAGEGNSIDLDSQGPDGRTAASIYAEEGRVTALKSLISAGASATFVDGSGRSPLLWAAFLGNISAVKYFALKRAIVSFDDMAVALEHHISSPAASQIFVHDLILAFAQPFDEEIALKLLELGIERGWEHVVAAALRAPSPLSPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4U3</accession>
    <name>A0AAE0N4U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4U3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="124" mass="13745" checksum="1A8B0A16C310C84C" modified="2024-05-29" version="1">MSPSPPQHFTTYSFALSLSRARTRIWGGPKDRNAELVTRANPFMLALCALCVFLSHSSSRIYANAACLIMNLTPCTFTLTNPTLLTSYLLSAYSFSFLSALFPLSCFFSMRVIITQWGGIFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N561</accession>
    <name>A0AAE0N561_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_319480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N561"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000165">
        <property type="entry name" value="Glucan 1,4-alpha-glucosidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042245854" evidence="15">
        <location>
            <begin position="19"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="119"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3370680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="46294" checksum="A73D85217D28BE20" modified="2024-05-29" version="1">MKWSIAAIAGLLAPSAFGAAVADKKITYNGYKAYRISTHHDDAVIKAKLAPLSPVTFNLDTSEHLDVAIPPSEVAKFKALGLDATVLHEDLGADIAKEAAFGTYDLTAQAVPSLTWFNTYHAYADHVTFFSDLRAAYPNNSELINAGTSVQGRSLFGIHLWGSGGKGSKPAVYFHGSVHAREWITSKVVEYITYQLLVQYSTDTVVKTILDKYDFYIIPFVNPDGFVYTQTTNRLWRKNRQTRSGSSCVGTDINRNWPYKWELTNGASTNPCDETYKGVAAGDTPENQGLVAFTQSLKNSKGIKLYIDWHSYGQYILLPYGYNCAARAANHARQTTLAQGTAARIKLSYGTTFTYGPSCSTLYATTGSSVDYITDVALAEFAWTIELRPSGSQGTSGFVLPAAQILPSAIEQWEGIKYLLTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6C4</accession>
    <name>A0AAE0N6C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_484489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="11">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="10">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="9">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3372371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="612" mass="65258" checksum="DC72C61062255A06" modified="2024-05-29" version="1">MASLTPLPPSPAYHTSLLTALDCRCHIHLILGSNPLAASRAANSLAAGAKPILISPVPEAELHYGVAAHISSGTVTHLARAFTEDDLFTLGRPEVDGVVDAVFVTSNARDAFAQTVSALCKKNRIPVNVLDAPALCSFSLLSSHVDGPLQIGVTTNGRGCKLASRIRREIAASLPSGLGSACARLGDMRRRVVQGDGHENEGVDDSVDQTASFNKLVTDADADAAKTRRMRWLSQVCEYWPLKRLAAITDTDVQDILKTYQSPDGPSLSSTNDSGMKPGHNVPRGAPTGRIILAGSGPGHPDLLTRATYKAIQSADLVLADKLVPSGVLDLIPRRTPVSIARKFPGNADRAQEELLEQALDGVRAGRTVLRLKQGDPFVYGRGGEEVAFFRAHGLGERVVVLPGITSSLSAPLFAGIPATQRDVSDQILICTGTGKKGKPPTPPEYVETCTVVFLMALHRISGLVNELTAHTAEEQGLGQQEAGEPPLADRNGEKVEQTPDQPSQQVQNRRHIRELWPLNTPCAVVERASCPDQRVIRTTLRYVAEAIEQEGSRPPGLLVVGRACEALYSPKRGRSWVVEDGGFKGLDLDSLDDFVPPPGAGSVAVSSKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6Q0</accession>
    <name>A0AAE0N6Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_496849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6Q0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="432" mass="47446" checksum="45709ECC4C059098" modified="2024-05-29" version="1">MHQHDGAGPSLPAQVLHHLTMRRPSRFAVTCMAAFFFLAAVWLYGETAMDSFGTTRERLPPAPLPTTVSLGSGGSKIPTTGDHTKVPATAGNKDTPKVDATKDTPKTEDIKVAPTPAGETKAEKDKSKEAGKEKGTEKAKPAAAPLDWPKTDIPPGDISHPGHISPKIWQILLQKNPSAKKVYPDPKSLQDTASWLAMNADYKYTLVSDQGGKDFVERRFAHEPRIVDAYNHMPNVGMKSDLLRYLLLDAEGGVYTDTDTVAIRPIEDWIPKGIERDKVKLIVGIEFDRRDGGAWADISHWLQFCQWTIAAAPGHPVFRKMTERILTSLDDIAHAHNLPIDQVKPTSFEVMNSTGPAAWTDAVFEQLQLHDSTLTSTKDLSFMEEPRLYGDILVLTIDGFGMGQAHSASTNDGTTPKAALVKHLFRGSWRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N738</accession>
    <name>A0AAE0N738_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_514019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N738"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="58126" checksum="7247D767809B9EBB" modified="2024-05-29" version="1">MAEPISIVSSAAGFISLSLDLCKGLKSYVSAYLVYEEDAKNVVEKLEGLQYSLALLGNALQTIEPSIPTDNHEIRQQLENQCRVGLSRLQQYLKRCGAKTNEASTSTASTPTPATKSTSALHKRRDRAIKRFIYPLRKPTLTEIGDTVDKIRERVQFLLDILNLVLQNVSLQRHTSTKTLVRSQNSDLQQVRSDIGEMNRRMERIVSKSRMLRDIGEQNQLETQTLIEAQNNKLQKLQVDIQRMDRRLGRAQPLARSPKTDGNAVEMSLIIAGFSRVCEYLLLQYSMARHWNVFEAYLRTVFGQRPGERFVKVKQYQLLRSRQNAFDLNLPKNEVGWYKELPPGAKFVMSLQTAADDTQSVGLTTCPRCQRYLDSKGRDGSIELVECTRDADEQKPLDDLLYLESSEVRLFKRMHLSERTTTAEADGPLGSISDEINETCQCELETNRTTIHINKLLKVREKNYDARVIDEDLKERFGIEGRCQSRKLKVICMVVRVLRRGHYIDVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8F0</accession>
    <name>A0AAE0N8F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="25825" checksum="AE665AF32615967A" modified="2024-05-29" version="1">MVNDTIPQESEQRNIFLGLIQEASANIPLAPPVPPSTSQPVTSAPSTRNVNSGVNATSETRGCTVTQSSTGDTAVVGSLTGTSIPLTVAPRIAPVKQRKEIPHYRRHAMRACGPPRRDWNLSRSSRGGKEEITSSMQQRQQRQQPYPHETAPTDDPAPIGNRKRKGSTSLEEDQPPASRPKSDREDSESGSAVRPVPAIRDQRWKLSSVEERRMDGQREGESIYDFGNGVKHIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG39</accession>
    <name>A0AAE0NG39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_474440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG39"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="42589" checksum="75D709A42A684FBD" modified="2024-05-29" version="1">MTPTELSDLIQNSTFPSPNNDTTPQDQDWDPYTLTSSFYGPGAFLCWYLVSISYTIKWATAWRASNTRPAHFPLTSDFIAMLAYPTIAAGDTIIRATTQFPPSEKHLLMSTMTLFRVFSNASEFATTRGINITTDLAADMDTLQHVVSVAAPLRICEDFFWPSLMMAMLAVLNDGPYGGPFIRSKIPLVDMTFVAVSVVNLSAIFVVAGVGWPGRMGYYEGLAFVSQYLGYVIIAAPIGMPVWLAVQLVKYWSEDLWDIFTDCSPMAVFLSSLFVVFGLTTVATFFIPFVVIGMWPREILWLLATSLVPDVGASMGELDQAAAACAGVITLGLTLYEASKVIPEVKAVVERWKVLVGISSAVREEDEVALTEGLLLEEGRNSESNNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG58</accession>
    <name>A0AAE0NG58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_434262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG58"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3380897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="179" mass="20236" checksum="295A4CF908098C1A" modified="2024-05-29" version="1">MAFLDTIISAVSNIAPYHLWIYSTLLGTELYQTFVMTKVSYQALPRSAFTTLQKRVFPLYFQGQTFLLGLAAITVPPYGLASLVHHKVDWVPFTVAGVTAILNLVIYEPQTRKAMVDRIHQETRDRKSGSSDDKPSAEMQKLNRVFSKNHAMSIHLNLISVGAMLFYGWRLASRFVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHH1</accession>
    <name>A0AAE0NHH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_208873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHH1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="487" mass="53167" checksum="69BFBFFD9B4E01C3" modified="2024-05-29" version="1">MSAFSVLTDDQIRELLENLTVDELEEFRAELKAALHQYSTGTQAPDESSVNQPERTSIHSAETGATTLFMPSCSPAGHGVKVVTLSSAESHDTAAAETDGAPAVIRPTGAITLFSPQGQPVGILHASTLTAFRTALASMCLVQKRETVRTISVFGSGEQAYWHVRLTLMLRGSTIKQVHIINRRFSPYLKDFMRRLYAVPAATKIREGWGECTFGVLTPTYGEYHRLLENQLQSSDIIFCCTPSTKPLFDASILTGHDGRPKGRLIVAIGSYTPNMHELPVEILHQATKVHSHHHFFHRHALEGGVVVVDTLDGALKEAGELIEAELQPKQLVELGELVMLQNASMTKDPDTLASDISSNLSSTASLPTSELEKLQLGSFNGSGSAMSSVFSSSGEQRSSSRSRAESPRRKSGSGSSSPHRRHSFDRRASDDRHKKQKQKDDHLAQWLCAGNVIYKSVGLGLMDLTVGMHVIRFAREKGVGTHVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHP0</accession>
    <name>A0AAE0NHP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_451026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHP0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="107" mass="11034" checksum="D9F0AA9475A3A964" modified="2024-05-29" version="1">MTASTCCGKSAECVCAKQATCSCGKQSALHCTCDKASSENAVEGARCSCRARPAGECTCDRASTENDKPAGNTCSCGSRPADACTCEKAADGKYNPAENEIDFTTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI29</accession>
    <name>A0AAE0NI29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_451172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI29"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="17922" checksum="604C841439948176" modified="2024-05-29" version="1">MASTQQAARVLHTSLDPTISRLLVVPEFPSKWPFIKAYLEGIFQDVEFTQIVQNDSYQMFLPRDLSAVEVTNLNMCSLTASLDPAELIANQQAWLDAPEPEQPEEEEDEDDEDDDDDSDYISDDYSDDEDDEGDDYITGPNVEGWEGEKSNCITDGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNS3</accession>
    <name>A0AAE0NNS3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_394527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNS3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3384931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="229" mass="24812" checksum="BD29E3CEDA4CA18C" modified="2024-05-29" version="1">MEFGNSGSLSEDGIHVDMDRLKKGEVNLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDTIWCCRSGSAADTQAVADIVQYQLSLFAMTNGKPPTTQTAASIFQEICYSNKDRLSAGLIIAGWDERYGGQVYSIPLGGSLHKQSYAIGGSGSTYIYGFCDSNWKEGMEEADAVNFVKEALKEAIKWDGSSGGVIRMVVLTGKGADRHLYLPDTDYKVRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQF7</accession>
    <name>A0AAE0NQF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B6 photo-protection and homoeostasis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_494623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="49881" checksum="492D01B956D5ABBF" modified="2024-05-29" version="1">MSKAVYDIDPAGNVLITYTQTGPEKETLRQEKTEVPLAKAILYAFLPAGYPHTVTDDYLAYQTYDSLQAFASSITSLLANRAVLEGLGVGDSSSSPTGALILKITGDTISRIATIMFAHRMGQAIEPECKFYRFLADIFNDSAQFLDLLTPALPYLPKLGVIVSAGVLRSLCGVAANASKASLSAHFALTGNLAELNAKEASQETVVSLLGMLVGSLVVRMVEDKQVVWMLMMVLSGVHLLMNYRAVRCVEMRTLNRQRATLVFRAWLDHSAVLTPVQVARRESILRKGRGNLASKSGDYTGFCDFGTYGDIKTWNPRGYHRYDFETPAYFLGIWHRGGNFHMRIALKEEGAAGASSPLSAWFDAVNHAYHFDSALKDGLQSHYENEMAPLGYVSEEQKTSLFAALTSAGWDLESNQLETRLPIRVRVGDGKKAPIVSEKDPAHHAGHQETKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQH2</accession>
    <name>A0AAE0NQH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_473617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQH2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="862" mass="96627" checksum="494BDFCB18F29DC3" modified="2024-05-29" version="1">MTTSNILSLPFRKSTQISLSGSIKQYILHKYDQHPDMFRHDLDTIDSLRRDAINVHEAHPSGIKKLQIYAGQLVWMGGKFPIDIGAEFTWYPALGYHTEHPLVHNNLKYELMNILYNLAAMYSQLAIASNRGSTEGLKTAASWFSQAAGVLTHMKNEVLPELRIANPPDDMDEATLESLIQLFLAQSQECFWQKAVMDGYKDGSIAKLAARVSDLYNLAGEAAMKSEAISSAWIHHTSAKHHHFAAAAQFRASRDCLEKRKYGEEIARLTDAVACVNEGLRECKGGYLNKVVIEDLTGLKKRVEEELKRAEKDNDMLFLQLVPPKSELKILERANMAIARIPPQVANPYEFFGDHAEFGPALFTKLVPFAVHVAVSIYEERRDRLVNNNIVAELETLTGKLHQILSSLNLPGSLQALEKPLGLPGTLVQHAEEIRQGDALNRLQRGFGDIEKLCASDRAVFEEGKTLLAAEEEEDRNLRLEFGKQRWTRPESRADPSRDGGAKLWNQAAEIEGYFASSTSSDAVVRDKYAAVKETLAILAGPDRGIMDFIPNSRRAEIPESLKPALGRLRGAYNDLLRLESRRRKRVEGLTARSRADDIKGDILAETARLERTYPSTPIATAHFEDFFEKRLDSLYESDVAAVEKELADQEKLMADLQRANQEFEAQKRSIGDKGNHDREKALQKLDNAYYKYKEIVSNVEVGRKFYNDLSRIVEQFRTQVRQWVNARRKEARMLEEELSMPPLSSLQIQQQQAPPQQSYQAPGPTSYFMNPPQPQSIRQAVHSPPAEAHIQSWADNVPQQQPKPMPPIAPVASMQGTWMPDMGIKFAPSPAGGANPQGGQVDNPSAKGKNTWEAASGIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQT7</accession>
    <name>A0AAE0NQT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_190033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQT7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="403"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123383" checksum="0F9D7C34D56AFBB4" modified="2024-05-29" version="1">MSSWINEAAVQNHNGNGFPHINDPSAVTGAMMDHSGYMGSPAQFNPQFANPQQMVMPNGPMRNASPSFPNPMYQTNQVIPSKRPRAREDSLGQSPRQAPGHLPTSRAETPQSQFSAFQQPGMPPQQQQQQQQPTGQPSPYPHLQPNGSANATPSPVISNQMRPGSVPQRVATTSPHPFSPAAQQFPQASPVPSEHGGTPQPYLQQQSNFQQQQNFNPQFTPTQSPARPSPTPNAMSGQMLPQQMGQLPQMQQLTGQMPGQLPSQMAGQIQNQMPGQIPNQMFPQMPQPRNTAMDQRMMYQMQMQQQHQAQQRSNMQMQHPGPQNMMHQQPGPNQGQMQAAHTAQAQAQRNMMAARQAMQNGQMPPGAMRPQQGMPQQGIPQQGMPQPGMPQPGMPQPQGMGRMQGPDSFMKNLAAFMSQKNMPLDPNPNVDGRPVHLMNLFQIVFHKFGGYRSITQSNGWPGAAQLLGFPPQHQSAPLQLRSLYERNLVKFEEYWSQQQKVRMQHQGMPNTPKMQHGTPTKAMPSAQIQQSHMMQPGQQQPQLQQGPIPSPIKPPGSQQTSVNGFPGPQPHHGPQPINAAHGQRNSMSRSIQPTPTAEEFPLPSPAQSKAGSMSLPGSAHPEPHAMHEEPMAQFPAPFATDPEEYMPCSREFTTYGGVDLMAVGKLADDLVRYKPDIPSALELGNVDIHALTRSIQSGIHGEVRLALDTLATISSGELYNGIPIPQIDLRYCDDLVETLVECAEEQADLLAENSEEASNEITISLYEDVIRACRTERLALRSVPLFGSPAYELDRAVDRLICITTILRNLSCREENHAPLAEDSVIKFLCVVIRYLGTREMLLRTQANTLDLMKDLVTLLSNIAGSVEIPGREQAFCLLQFLLAFAPSPTPTLSNAQIFFTSYDPALHPYLPHAVDSLAKLLARDEPNRTFYKAIFAADFAANSSPPGELLTRAFALAISPIPDHSRDARQSHLPSLVEARKPFLMQGLLAADIMAALAPSYETGVTRAWLASGNGFAQNLFLLVRQLSAQFEGQPMRPGGGQMRNHSKRDSELVYIVGLAVSMLKRLSEKARDPNNPTGENSIPPNVLPGRDSLLGALQMMAQEWSKAGMLQDLVAYAALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQZ5</accession>
    <name>A0AAE0NQZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_560560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQZ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3386102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="336" mass="37887" checksum="24106CF604F68CE4" modified="2024-05-29" version="1">MTLLKPTAAPSAETRASSTARHEEHQYLDLVREILDDGELRRDRTGTGTYSVFAPRPLKFSLNKSGTPILPLLTTKRVFTRAVIAELLWFVEGNTSSAPLSAQGVKIWDGNGSREFLDNLGLTHREVGDLGPVYGFQWRHFGAEYVDSQTDYTGQGVDQLARIIHTLRTNPYDRRLILSAWNPKDLPQMVLPPCHMFAQFYVSYPRSRETEDQETEDGEIEEKEKPKGHLHCQLYQRSCDMGLGVPFNIASYALLTHMLAHVCDLVPGSLTHVMGDAHVYLNHVDALRTQLDREPREFPELAIAREKGGGIDGWKAEDFVIKGYNPHKIIAMEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR85</accession>
    <name>A0AAE0NR85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_190581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="365" mass="40836" checksum="6C462E6E23938184" modified="2024-05-29" version="1">MATNETQLEPPECSFKGNPDLYGLGLRLAFYITCATGSIASIFLDKQFKYLIDSSVAFCLATLFVLVRETVAGTLYASEASLFFWLVIIQVLAVLNFKRAIIASPLGYMINLLLMVGFLVYASWFWNTGIDRLPRVGDGCTEYGFYFFKFDVRSFWWRLVNRIVFTILTVFLGFFAVLIAGFIGFIFVIFLFKAIRPKKTRPPRRDRPSQAEDQTPLDPMDDAHTAEFRDMVKGTALEKLLLSNKADKWSPLARGIGTGFLIVLTSFWMAFFIHAVELQIQWNNIRGVQRLDSVGQLIPFLLSVGMLGHVLYSIIWRKDIAAGAEQTTSSVAEVSESCPYKTAANTVGQHELLPVAAQVPASPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRA2</accession>
    <name>A0AAE0NRA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_523393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRA2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="99" mass="10852" checksum="4EA7D4ADB83D996A" modified="2024-05-29" version="1">MSSKNPIRLPPLKRLRVRNPNKSESNPCIAIMSTVLSCWASAGYNTAGCQHIENTLRACMDAPKAPPKPNNTINYHLRRLSDHVITVGPKGGKKTKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT12</accession>
    <name>A0AAE0NT12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_152583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT12"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042004229" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12724" checksum="B8524B57FA2C95E8" modified="2024-05-29" version="1">MHALTWLLASRPFHAVLINCPLQVLGLRHMSILPKRPWILTVIAPIGPIHGSCRVPGRAPPSPSVPGHRTQNGYARLGRLLIGQVPATQQDGKGSPGVKGLFVRDAVHRPTVQVLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTR9</accession>
    <name>A0AAE0NTR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_469896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261820" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="62454" checksum="E72F944FD930BD8C" modified="2024-05-29" version="1">MLGSRLVHALWAAGLAAASALSPLDIHVQTRSLPGSSDADTILAVRRGLAKVAAIHGRDTIATNTTTIDRTWNNANLFDFLGVKVSCITCYIKGKTRAELTINGGFNASDALDNVTKQVGAKIKNITEEAANEIDDYFDHLQSEFLSGKLSRDDFEFDNFSINTDFNIDIPSIPECLLSFQFEGLELYMHLDTTLQINGTFSIPLFKSQSPVGVSSGDDFEIGIFLTLDLILSAETQINFLSGFHIKLDDKVAINLALFSKEVSKVDLKGGKFEFLPVQVQSGDTVLKAVLRVGAHAGFKLGTPSISILGVDVPGASAGVEAGVFAHIAEFVTNVQARPNDVACKLRVVEEYTMALGAMAGATVGLGPGTWGPNPATTTAIYTTTFTDACAVKASAITTTTAPPNIPRDVVEARQGSTTRRLTTTSTTTKYKVTAVFCEAAGLVNCPASLQKTSVNEITSTLFTAVPSGVRATFSFPTTTTVGVANATPFGAQAKDLSATSGVPTPYASSFSEGTTGGVSNKVIIGVAVGVGLPVLVGLVVGACIFFRRRRSKAGKHDGAFGSVTTNTQTGYNSQGPWAAQKGPAVGVQEYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU54</accession>
    <name>A0AAE0NU54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_521799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="4">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="1982"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2637" mass="292119" checksum="3A2F0717E60E2CA9" modified="2024-05-29" version="1">MDYSWRGTACEEEPVTVNTRALIENVLARYPGEWTTLRELIQNASDAQSTTVKVKWETLPPKAAQGQPLPITRAASDGAAGGSEQLKYTVTHHTMRCLRVENTGQPFTAMDWGRLKRIAEGNPDETKIGAFGVGFYSVFGDCEEPVVISGSEAMHFYWKGNSLFTQKHSLEPAQSLRGTRVILYYRDTKMAVPDLLSISRFLVTSLLTAAKLDQIELWVDEQQVLTLKKRSLAVVNTVRPTDLEAVGKGDFMEISAVQQADIQIDATAMGIVGWKPKAFESGEKDEDLTLMLTSSTRLRQNTASIATSPPQALANELERATKKNAPRSTSLMVLTSPQKEDPPGKVEDTTTPNNSSTQLNANIFSSALPLGRLGGRLFIGFPTRQTTGAGMHISAPAIIPTVEREAIDLNAHQIQAWNVEMLRVAGTMTMLSFIDAMLDLRNKLQGHSQSPEGTSTEVEVDPETDDEAEALRVLKTFTFIDSTPDKRVASTIEEAFWKAYERSTTKLVYSSRGVLPTTKVRIGREELSKFVDGIPVIPPSMRQESFVTKLRDRGFIKQISVEDVRNELETKPLGNRGPIQAFLVWAGGLAASRALTSLDKKSLLNAARVHIAAVGEGEGDGDAISLRDIKNYAHTDPPIPEGLPLPPTCLPSNFTASVHVLHLQALGWKPLKIIPWLEFLVAAPKDDENMTKSLKVAQLALGFLGQQWDKLEPTSKPAVVAVLKNVPSIPTKHGMRKPAESYFESVTLFKDLPVIEYGSANSDAVSPVLLDLGVRKTVELETIFTRLFAEGGQEQWSYMDLITYLSSVKDDIPPDDIKKLKEAALFPAEAAPSMPTNSSPVLLAISALFEPVKRLRELRLPVLHWQLSTPYSPDSAEGSFLLFLGLRRHPSVPELVGMMADRDPALRSSAMSYFIEYHQINKCPVLSKLDVSEAILPVQGNIALLVPPSECCTNMAAAVLGYNILRADLHQHAHKFGVPRDPLISSCVDRLISVRRPLDHGTAVVVFEYFTSRLGELRNNDIAKLRDAPIVPVILWKALEAQTNSIRHISPRACYLGTVSEYATVFDYVDFGAAANLFLDKCGAKRQPTTTDIAHLICDKPRHALEVLQSPERYLNLLLRPLARDTKILADRSIMRKLQSSQCLLGWTEKEPLPQARTETSDGLDQNKAPVKKYVFGTSEEIVVIDDWITYSIFKDSLLCAPDEDSLETLYRSLGSQNLSSLVDEDVIVGLHVQDQTPAEQLRDLILERSLFLFFDFRKERNAMRHDEEWLKKCLKVELVESATLHRSLRGGNEVQHRTENQAAAIAVRDGVCHLYIAGEDRRDRTYQISKTLCDLLLIRPNYQAYVYFEWLLRSKRSDLEHRYNIKRILRVKDPEPEIIPIVEEEEQPQNNSEEFSGTSGDQLESSSEKAPSGSAETKKRSYIFQYLLTANLKAVVLTVFAIGFCLVLWANNSRNLATPHGILSIPPTSPPMMVVGGHTRYLFVTDAVKKKHPAPIPEHSTSTNPKTATRNRSIELAMAVLVIFAVVLIAGDLIQYLKPKAKADSSGSKIEDNGIQNQAASFTEGGNSDPKDWESEGTSTVTSISTPRLKVKGASKLEEVQKLLQGVISPNLSSPKSPRTDDISTPDSELSTSEATLTQKLAEALINSDNTAQPAQNMRHGQVGSEWATSHESGPEIDIPRDSEEDVSLVMNKPNNQSPLNTRASDRLVSSALSAISAQLPSQDITADQDERLAKLFKEIQRSAVDIEVQINSQLEKLAINTNGGGSEAEYQAQNHWTSTLRSGSGILRYVAKDGDEYTCTFTITNNKGKLRDAILGSQHISPEALAECVTVHIEVCSTDGDLDSTFVLPIEQHEKLQKMRLKNKKKQNHVYVLARVYRVRDSLGIAMFADPWQLEQDGHITLEKVAGYTSTVTSSAPAILKEKFASDRKQDLGSIYDGDGTLGPNKIRLLTLDLTDDSAPLTGSLEVVDVNQLKRGGGFWAISYYWGPPPQGDNPSKFRTSKGEMAITESLASCLSCLRHQRVEAPIWADALCINQANETEKMMQVRRMGSLYAEAAQVVIWLGTNGCAVDQESPEVRFLTDIHSPFCSSTGRCQKTGQLETSPAKNRAASPAPDDAQWAAVNRFLKHPWFTRVWVVQELALGGANVFIMSGESKMGWDCFMESLFVQSRVFLPSLSGAMALHKTRKIHRAEKRKFELLELLEMFAYTESTWPRDKMFALLNLAGDRYLGEADFDPDYVSTDEAVMESYARGFVRHRPRLALELLYHAGHAKSASFCSWIPDFMGLRFLRPRNFRPLSTAERRLRTYPPTISMWKTRRGSGFFAGPSGQPGAQVKPSLKVDFTLDAWGAVSHAQHPPPVLAVRGYLIDQVRECHELGLQRPGARIAFARALGNMRDYISCLNGYPDTDDDGDDDSGELGAGMGWQDKLLLRLLVGDARGPHVDPDSDWAAHFKLDSEDNEIEDENQDNNRPWKTTAALLLSPSPPPRWPPETGAEVLSLDLSQDAHGYQDKPPDTQTRMMQYWQTAWTFANRIPGAVFCMTRGNGTTAAAKDSLTLPNIKDSSNTNNKRYAGIAPGAARPGDHIFVVNGGKVPLVLRKVTGKPYYRLIGECYIHGIMYRASDAVCAEKDVEICII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUV1</accession>
    <name>A0AAE0NUV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_431940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042296080" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="350"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="452" mass="48914" checksum="676C0130DB8A2DEF" modified="2024-05-29" version="1">MKTQSLAVLSAFVSSSDAFLLMGQHIAHERVDPIVQPGVVSGHLHDVVGASTFGVNFDPAVWAKSNCSSMQVQENKSNYWMPSLMARNDNGTFSAIPLLETRVYYLNNHPDGTKVKAFPQGFRMLAGNPSATAPTGHMDLMSSSGFQCQNGRNDGRENIQPHLPYFECLDFTRLTLAFPDCWDGINLDSPDHKAHVTYRLGNGTCPLSHPVSMMEIDLELGYWTRGYRWDQLLLSTGDQAGYGLHADYLSFWDVDLLQRALDDPTCQHRENIFGDNAQCQALLPYRNDAAMQSCKLEAKIPQEETGITKPIPSLPGCNLPWNATKGEAKPSCPAAPATPAIGPAATPQSSWANLGCYTDSTTNRGLPIQLKSIPSGTMTIDKCVAACASKGYTFAGVEYSIECFCGNAIGGDSKKANQADCDMKCSGDASQLCGGGNRVNVYAKAIGVVDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX05</accession>
    <name>A0AAE0NX05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_445419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX05"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="58732" checksum="456153F7815C7726" modified="2024-05-29" version="1">MSKHVPTSTHWVTFPSEPKSKVLIDWTDDGHHHNVYYVTKCYWGTLPPTVRLSDPAPEPVAKYTSSSKTASEKNSSEIEILEQALKAKGVNVDHLSKEIVQQEQPRPRVLVDQALHIIGETRIFIAAEFVEDQYRGGPMLPYHIKDLTQRSPDSKPGSWVTAQLDECFHYGQYSSGDTLNRWLAYHPSISKGIPSPRMFQHRFTGLPALELTKTVAGELPGLAPDSTIKAGAKLTVKLAEVGTNVMKRVAGHYLHPFLNAQKRAVALYLQRLIEVDPPKDSTNKTTTNTPEVETAKIIAMQVIETLVAGRVNKKTEEGQAQRLKAELEYCKKLNTGINSSGIKKESWLDEITKILKSEQPPPSTEQANKILTDSNLSAGDGDRAMFADVSSNVTGGSVHLPPIDNKKAGNTGEQTEHKRPSFRIGQMENKAVVDAQNNAHLDAHKDVTTQTHTSSKSSSFPRLKQNLGIQKPQHMENTSLARNTLGGRLKSPNATTGNPLVNLVQGKTNNNNLMQTPRTKENPLLRNLKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXF3</accession>
    <name>A0AAE0NXF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXF3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="21029" checksum="7108E5E000DDCF7C" modified="2024-05-29" version="1">MRRLAGLQLGAIVNSATDVQMNGLVGALRGQQLKPLLVNGPRQPRFKSGKRVRMARRGGRSFVRRNWALFAAPTGSNGGSKSNPQIGLSSQPFHAMPRISVSRILAARRSKQILNAKNRGPEQHSMAQLLAVFSAPRSHWLLWTCWYQDGIKQAYVPLLWYHWARLANDFTDRSGGSCESQPLAPGCQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXI3</accession>
    <name>A0AAE0NXI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_507015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1295"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1333"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1363"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="170"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="881"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3389429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1516" mass="167923" checksum="34FF10C8C21BF955" modified="2024-05-29" version="1">MVLYRTTETRFGARGGVFVGMIPNIHSAYSCSDSSGSSISSNDQSTPSDYSGDAITPVGDGQPPADLEPLQNGHIQRHLSMIDESDAAELQKIATALSRHQSHATAGRSHQEALGGDPGGDPSLDPASPDFDLTKWLQNVVSQLTDRGIERTHSGVVFQDLSVFGSGAALQLQDTVDSMLLAPFRPSKLFSHGNGAPKKKQILHGFNGLMRPGELLAVLGRPGSGCTTLLKSMCGELHGLNLGDKSVIHYNGVSQHHMMKEFKGEVMYNQEVDKHFPHLTVGQTLEFAASVRTPATRLHDMPRNEYCQYIARVVMAICGLSHVYTTKVGNDYIRGVSGGERKRVSIAEMMVAGSPINAWDNSTRGLDSTSALKFVQSLRLASTIGNSAHAVAMYQASQAIYDLFDKATVLYEGRQIYFGPASAAKAFFERQGWACPSRQTTGDFLTSITNAMERIPREGMEKRVPRSPEEFERYWLESPEFKALQAEIQEYNAEFQGQESIARFREQKTMRQAKHHRPKSPYMISIAMQIKLNTKRAYQRTWNDIAATGSNTLANLVLALIIGSIFYGTPDATSGFAAKGSVLFMAILLNALTAISEIASQYSQRPIVEKHASYAFYHPATEAAAGIVADLPVKFVIAVIFNLLVYFMAGLRREPAQFFIFFLISYISTFVMTAVFRTLAAITKTVSQAMALAGVLVLAIVMYTGYVIAVPDMHPWFSWIRWLNPIFYSFEILVANEFHGQDFTCSAIVPPYSPPHGKSWICASTGSVAGQWTVNGDAYIQTTYGYTYDHVWRNFGILIAFLVFFMGLYFTATELNSSTTSTAETLVFQQGRVPAHLAPKSQHSGTTDMESLAVKGADDHGAVAESNPPTATGIEPQRDVFTWQDVVYEIDVKGGERRRLLDNVSGWVKPGTLTALMGASGAGKTTLLDTLAQRTTVGVVTGDMLVNGRPFGADFQRQTGYVQQQDLHLDTATVRESLQFSATLRRPKSVSTKEKYEFVEEVIKMLGMEDYADAVVGIPGEGLNVEQRKLLTIGVELVAKPKLLLFLDEPTSGLDSQSAWAICVFLRKLADAGQAVLCTIHQPNAMLFQQFDRLLFLAKGGRTVYFGDIGDNSRLLLNYFESHGARHCDEMENPAEFMLEIVANGHNASGEDWHSVWKSSSECQEVQAEIARLRDHDSAQEHEETGPGEDSHTEFAMPLTSQIWAVTRRIFQQYWRMPSYVLAKIMLGAASGLFIGFTFYHANGTQSGMRNVMFAVFMLTTIFTTLVQQIQPLFITQRSLYEVRERPSKAYSWKAFLFANIFVEMPYQILTGIVTFACFYYPVVSVQSSTQQGLVLLFVIQIFIYASAFANMTIAALPDAESAAAVVILLTMMSTIFSGVLQTRAALPGFWIFMYRVSPFTYWIAGIVSTLLHDRPVECSAVETLIFDPPSGMTCAQYLQPMLSAAPGTLQNPAAVEQCRYCTLSVADQFLGSVDIFYSERWRNFGIIWAYIIFDVIMAVSLYYVFRVKKWSFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXQ2</accession>
    <name>A0AAE0NXQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_428170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="124"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="675"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3389642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1414" mass="155859" checksum="6F61640A2336D19F" modified="2024-05-29" version="1">MNPQTPMRPVPGAYFNTPAPGGATVPRRNLNFGPGAASGIGGTSTSGAVGGGIAPLSMRGGGGGGGGGPLASRSGATNPPPPVKQAADCINETLQLDESFPDLDSYCRPGASSDYDLQSYDSSWAPFHKVQMYPIPDEVFRRVDQGTVQTRLGLFANLNYAWASIDSSLFLWDYTHPNPELIGYEDATHPITAVALVPPKPGVFVKTITHILVVATTADIILLGLSATSAPSGSKTVTLYQTKMAVNRGSAEVSIIVGTQSGRIFFGGANDTDIYELFYQQEERWFSSRCGKINHTHPGWTSVVPILPGPIDFFGSRETEHLVNIVVDDTRNLVYSLSNKSTIRTYHMETPEKLTKVIDKSKVDCLRDVTHMVLQRSDLLNDNIQIVSLSPIAATEASKLHLMALTNTGCRLFLSATSSAQYITGASSSLAPQSMQVQFVKFPPKEAGARARAPVPGSDVLDVASRALTTSTSGLRFAPGYFFDIVNKPGSPSVDYLFVSTPDTGRIKATGPASALKYFEQGNWIELGGRACDIGLTTSSFAAAKQPLGFGNELAVQFDQLPSEFTVLTNSGVHVIRRRRLVDIFATTVRSAIGDEGLEKELRKFINQYGRVETISAALAVACGQGNDLRTGTSRAVDQATEDRARAAFIDYGGQPRLAETDGSQLTTTTPVKLSSRHDALALYLTRLVRKLWKSKVISAKTDAKKGILSVTSTINTENLVTVQENVERLRRFLEANKGMIQGLAGPSDRMASKQEELALQKEHQALHSLRKLMESVSEGISFVLMLFDERVTDIYIRLDDTTKRQLDDLTYENLFSQAPGKELAKVLVKAIVNRNIASGANVETVADALRRRCGSFCSPDDVVIFKAQEQLQRASEQAHNANVLRTLLAESLRLFEQVAGSLTSANLRSAVEQYLDLKYYAGAIKLCLTVASQRDRGNTAFQWLQEGKPANDDRKRAFDKRKECYDLIHEVLDRLEATSGAEPDYVDGRLTLTATKRLEAYDVVNKSNDEVFHHNLYDWYISKSWTDRILSIESPHVITYLQSLAATKFTHAELLYRYFTHRQRFLEAAQVQAELAKSNFQLSIKDRITLLSRAKANAQVNSGGISNQDRTRLLHEVSELLEIAHIQDDLLERLSSDPRLDEAKLAEIADDLNGPVQGLTELFNNYADQAGYFDICLVIYYAGDYQNMRTIVETWSNLIDNIHNEITDRRLLWEQNQAGMLPPGSTAPDEELPRPYEVIATNIQNIAHRTSTDANVFPIDQLLPLICAYAINESQDESIGADPCWPVLVFLGLGFNPSLIVRTLENMLDSQEAPFQGRRRQVVVQWIKEAIDVWVRDVERRGTVSKGGDNTINVWVSELLNRADEALQQIAAGRNVPNVADLQRLSQATRSLKRKVDNILLAEHQGGLRFNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXY7</accession>
    <name>A0AAE0NXY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_102925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="297" mass="34091" checksum="A51D4E9F39B35112" modified="2024-05-29" version="1">MGTHDLSLGDIRNHCREKVRIVDHTLDDAQLDARCPLDNGRHAVRPKTSVGQLDLLPAELINQLLGILDIPTLTTFRRVNQRAMFLVDSLPPYRRLWMSCPSILRAVVSINAASFSCETLFRTLTKEKCESCSLFGGYYLYLITCKRVCYFCFTGRKEYFPVSLTLATRQAKLPKMALRHLPQVLTLPGRYAPTAKLSTYRITLVDCQALLQLSEEAEMMLNKRVDYKSTEPRRYMSIVAAPRLHLHDQTADWWGLYCSLCRDNTEPSSHFRIQYSRQDILQHFKDHHASQIASPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY21</accession>
    <name>A0AAE0NY21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_103277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21189">
        <property type="entry name" value="PHA02142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="611" mass="68795" checksum="C512418F9FF91F79" modified="2024-05-29" version="1" fragment="single">MSHLYGRNKQQTASLRITIVKMAAQSGNANWRQFVLAAISQQNADLTVSREQQAATTPESTNGSHSHAHPSPTRESSESTTTKPDTYTRKLATVRRIESLRPFSREQQIATFKGGWTVVVKTGKFMEGENVLFCEVDSFLPIIGPHGSVFAEVWNMKSFEGKNGYLVTTKFSINSEKTKVISQGHIFKLAAFPGIWPARQPFDTLHEDTPNSVGEDVHVDRDEKIDYAPQLGIVKYDPYPERTDQAPAIGPVPKFIIKADMERVQNCPNLFTKLKYKRFTFQESVKMDGRTMTCYFVPRTSRNYQLLARLPEGNHMMRSVHPNGRFGVCSRNQDLNSRSKSIYWDSAMNANLHVKLAKLGRSIAVQGELVGWDLQGNPHNYEKNQYEFFVFAVFDIDACNRWDPARVEVFARNHGLKHVPVLGYHKIPDIARNHEDLITRADMTSYEGLVFKNCADGRWFKVHSPRYLLRRGNEGNWSNPAPARVASPALVDYQAVSSPSTPSASVASPANLPVASTTDSSVVAVLGGWQANPQDMNPLFQAYRQADEMLATYPMFQAYMRDWHHAGASGASGFVSDPEQARIDQPNMWTWRNWLPPHEGGWNGGTIRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY94</accession>
    <name>A0AAE0NY94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_388533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY94"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="468" mass="49651" checksum="5D3C295CEF5F1F08" modified="2024-05-29" version="1">MSSGNSQDTSSTNDADLVFTPPASEGGMSPGNGSGRDSSQESQLLQLSQIAAAQERIPDSQGDAAGNAAASRKRMADGVVKHTRDNSSASPVRMGGHSRNTSTVSMASNASSRIGELSAELKARLTYAMVKVNHGWQSHTIDQVETLASQAASPTSSTSTIHLRNGASASPQLSNASHRGSNNTTPGTAPQHQFPTRLDPIWRETSHVGSRGSSASPIKPSHTLAPPVSIQPARHLSHPRRNSNPRHAPTFLSNSHQASPNAGPHTPGQPSPYLGSAFQRTPNADPIIFSPHQNVREQDAIESLLFMSSPGNSANLKHAFSSQPAHSNHAAPQRTALPSSQPPRKSLPSGRPTHARSQSHTQKRVGFEKSPRDMDIDESFGTPLSRGTQRRKVNGIAGHGDVHSMPRLKHFPLSTGLTVPTRPRPVLGDAEIDRLLDRAAAEGDSDSDEEIRIPAGRARRDGAHVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYK5</accession>
    <name>A0AAE0NYK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUR7 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_445967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYK5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="40078" checksum="4BE81B5D548465A2" modified="2024-05-29" version="1">MAGAGRMCIGILPSIFMSLSFIMILILVLPGVNNSITQIYFLKTETSGLSAPPKLGNSDFLRDLSTVSGTDFVGQKTTAADLGLADSYTVHLLTVCGHFSGGSVSCSTPRINFAFDPSLDLKLDRTSLQGTYSQSYLDALSNYSRINHFLPGGYIAAAVFIWLAPLAACFSAVGATILSSLAAILLLSSSIAAGLTFKNMNNAFNDNFNASGLSSSIGTIPIALSVIPLVFCLIATGFYVAQARSSSAKARRRGGVVARSVGGKEAEAYGPYGPYGPYAAGAHGGDGVWNRGQHKYAKVEAGQDATDQREAMLAQSSSPSPDMRPKRLDDDWAAPDDYAQSKGTAAAPGPSDPAAVPFISLGGNKPTKDLNTAYEPYSGTGTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZI2</accession>
    <name>A0AAE0NZI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_116026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="106" mass="12635" checksum="B33D93074085B725" modified="2024-05-29" version="1">MPTRRAFLPFFLFHWLNEQFSLRYRQLKSKTGHQAHRQNKTRTEPKQKERDKNNVHNMPLERDVQVNMVVDIPLRNVRTSSPTACQIEANMTEHVKCKSALFLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0X2</accession>
    <name>A0AAE0P0X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_540041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="127"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3391303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="669" mass="72304" checksum="CADA11FC3C2D3103" modified="2024-05-29" version="1">MAYVQRLGALAAAAALLAPYGTQALFIGGGLTILSRNSLDADFKAALNASLSYQTYLGLAPEDQIYWIAKSSDDDDSCRGIDAAGREYDLDCLNEVPILCTQSAPVSTSKFADNARAWQVTQYVGNKRVTGYRDYHTWKFRGLRYADMPARFGYSAATAKFEDEGEVDATNAGADCSQPIGEVKNGSSEDCLFANVWTTHLPRMGDKDHPKKPELKPVMLYLYGGGLTSGSGKNPNTDGTNLASRGDVVVVSVNYRVGSIGFLNLNDGIHRGNYGISDMVSALEWVNKYIAYFGGDPDRVTLFGESAGALGTHVVLGVPKAKGLFHRAIMQSGPDGYPSNGKILQYPYYDSLKHNYATTTKTVLREAGCTNATDVVACLGKLSGFDLVNLTTNANGIVVDGIYLTYHELVVNSSSASVATNVSVMVGFNRDEAGVNIDNYPSNTTTLAEYFNTEVGNHFSMPSNASSILRLVNSTSFPGTAALSTPAGVFDLAVRIATDAVFTCFGLAKAYSGAKHSAFKSTYVYQFNRTYQTSGYTRPWCIPPKTAARPNGDPDGEYKKCHAGEQMVVFGTERRGGAPDRDGLDVPFMGLVVDYWAAFARTGEPDPDREALKIRGHWSTLKQLEKTGKWEKVDPRNPTLRLLQWNGGQVPFVDGDICKALGAGLDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3X2</accession>
    <name>A0AAE0P3X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_443228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3392938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="398" mass="42831" checksum="1ED4BA0D1502A3B4" modified="2024-05-29" version="1">MASSLSPNQSHSSFGGGGPSGQDKSPLSSLNLGFLKGLTEKRTTTRDGQPTKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEDEVLRLKEIYSNVSQDKNKLAEENRQLKALLSQNGMGVGTVTGGGSMLDDTMSNPSVGYTSSASVSGGYAPASSNTSAFTPPPLSATTNMGHRGGGDGLSPHALTIPHDQHHHHSSQSHMAGSGAGGRPNQNPTLDYDQAGIDFVLTLEKPCMDHLPWLLERGSEVGGNEPCGHALMASCPPEPFPELTPDIPFGYANVRANDSPGSGSNAVEAGQRTWELSKGDLTTLLDLSKRLNLDGEITPVMAWGMVLGHPRLAELKEDDFVRLAEELGGKIRCYGFGAVMEEFEVRDALENVLSTKPDFSMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3Y6</accession>
    <name>A0AAE0P3Y6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_3006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3Y6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="42177" checksum="904A68C86AE6EE05" modified="2024-05-29" version="1">MPALSSLWRRSPTTTGTSPPSKIDLPSELNDQLTVVTAASGSKSRKLLQSKDVNKPYLPGQPRIRLNGTSQNVVDPGLDEVLAYLRKNHLTEALDELLPYMRYFFVQTPAFNHIFPLHHQKAHAREIMVNEKPGLHLVWYYERIFVKPIPAYFLSQAFWDYIQEAEADVYRAGVGFMRSYYCLIQYELDFDLAVKLRLIPKLSSTNEFPTYEEWCAFIEPFRHVDEATVNRRYHYGELRLTRINRTAMFFKFSLAYFHIFPQWGSFLAHMLTPIVTIFAMCSIILNSMQVTLAAIDMGEYDDSKGWPSFVNVSIYFPIAVILLIGTVLGAALIGIVFMGYKDFTKGNKVRDAKKKGDWSVGEKSHGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4K1</accession>
    <name>A0AAE0P4K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_2792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4K1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20330" checksum="BD1083109AC5C40B" modified="2024-05-29" version="1">MALNPWQDGGNRRATWKCFSDLVSLFLGCRVTASCQAGKRGQKLMRRLRAYALEVANGKANCVRLPIQLQARKEQAKQSPSRSQKCTPSMLNGKRTLRSPFLSPSLSLSNTDVGNRSAVYAPIPETGDHAICVWCAGSELSRCDSYCVSRLASCMGDGTNPRYLPAPPIPIHTSPPRYGILAGAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5A2</accession>
    <name>A0AAE0P5A2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_21240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5A2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="13621" checksum="854B397A67F6B1D4" modified="2024-05-29" version="1">MADRQPPNVVEGATTGADVEDEMEPVAKSAEDRKAAAALSKLDTHGDDDAAAPARGVDQEAVLNAMNALGGGAKGADDKKKQEALKKVKVDAADVALLVDELELSKAKATEMLKAHDGDAVKALRAFVAPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Y7</accession>
    <name>A0AAE0P5Y7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_31844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Y7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3394003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="36562" checksum="D3108DD037DF6028" modified="2024-05-29" version="1">MSDGSRKAPTKSYFHFAAGLGSGVLSAVLLQPIDLLKTRVQQSGSHTLSGAIAEIRASSTSLIPALWRGAVPSALRTGFGSAIYFTSLNAIRENVARRAHAIPILGTSTQQQHQQQHQQTSSSLPKLSNIGNLLAGGAARSLAGFILMPLTVLKVRYESSLYAYTSLASAGRDIAAREGLRGFFSGFGATALRDAPYAGLYVLFYEQSKKRLSALFPPPTATEKHHQKMGVSRAAGINFLSGVASGVVCSVISNPFDAVKTRIQLQPGAYRHMVHAVRRMVGEEGFRALWDGLALRMSRKALSSALAWTVYEELIRRAEVTWSSSNNSNNNGGDRAVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6D8</accession>
    <name>A0AAE0P6D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_36264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6D8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128916" checksum="D9897794A3F9C90C" modified="2024-05-29" version="1">MGNAQSSIEAPPRQSHRLSKPKTGNHATAGLLSPNGFSNTSRHFSSARLSTLLPPLPSQSPDLSSVSTPTTSTPEASTSLEQRSPIERSTSVAVPAQKKESLDWKRSLFRSKSSQGTSDPKRRNSIVESASRVADKLGRANSMTYESAVSYYGQPAPENWPGPPRTRSSWNYNPTSYEAKRLLNLEEEPALEHATTMSENRMTVVTESTWKSSNPANPESAPISRVNSDMSLYVPVRRRSVIQKPGIATRSNSMQNSPALSRSNFRYSHPPTPNLSRQQSFESYRGGVISMPPRMPESDQFPRVVTPCEDEYQSIGAFKLGSLRITNGAASPEIEKTRRRVQMGQRDPDALGDGYFAGAQPGNSDDTNGAAPSDVLPPTVEAPQPRAVQLSPIPTSFLSLEEVASAVSGPPMSEDLDSTVIDAPPQFLAEIDFSPFSFHGSQPGSPQLLTTSKTTALEDDLFDDEAQPEYSSVEVLDVRLDPSAKSPHGQVSTNVDKTFGRSDSGFLSTSSPSLDVIHKPLTKADSGYSSNVSLRSFQLKAQLSEGDLASSLEKQPSQSSQKSLTVPSEDRSLPRQSEESYPMPPQREAPPPPVPPKDLPQPLSPIKVLANVIPKKSRTTSVRLPESSFSTANISKTARHIPSPISLPYIDTRLKSPEPTPRTPASARSVKSDNSASALSIGSGPHKPGKLQRLLSSARRSAAGPLTVHATHVVEKTGIPSIPRDVEHKLHEHSGQFPMTTKRLALKPRSSKDTLKTIFSVGSMDVSVEAVNAIPMVPRVAEADDEDAAETKEPLWRQTLHSVPTSIAHVASHVIPRKPIARKPVPVRHESLKEKGQRLEKSATTRPNLPNVARPTSNTVQPLHHITRTMSLTMGAEQNWEMRLQALGSNVVYSTPDLPSSSLPSPFLARAVAMEKKARMSPPVSMMNRKPMSLRVPPPLRSQSSTASLSRKGSRESIQSYPSAQRLTRTASRDSIHSYPSHQEDHTASNIPNPATSPPPMDPRRIMSFRHSQTAQPSLHRAPSWDVQTDHDITRRSSQSSLNGVSRHNSLSSVPGQDGPGIQRPSSAQNWQVRTNQPPLRHRASYDGYNHQQHRLQQGNAPSMSNGYTAPSKPTLDPWINKQLAAPTGHRAQDGPYPPHVPRNHRRNHSVGSRNGHSTNPPYRILHSYNSPAYRGVPIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P776</accession>
    <name>A0AAE0P776_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_54442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P776"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="556" mass="61612" checksum="97BA8E3F445009F0" modified="2024-05-29" version="1">MSLNRVSSLETFAILHTDQRSRRSSDASARARKLSFNPLPQSWDPPALEQIHAVGAFEVPKWKRVLQVTVTVIYCLFSAGVVFGYAAIKPVLKHEGAYQHICREQTAVSEDTCIEIHLNLMFTVAAVATNVAALPIGAILDRYGPRVCGLLGAFFLAAGALIMAFEGQLPFDGLLFGYLFLALGGPFTYISSFQLSNAFPRNSGLILALLTGAFDASSALFLVYRIIYQKTEGSFGHRRFFLAYLVVPVAIVIIQLTLMPAQSYKTVGELVEEIEEPLPDDEPYDQIDEHTALLHEEERQHREEVVSGIQDLLGSAKADKQAKREERKNEISGVWGVMHPYTSWEQIKSPWFILICAFTVIQMTRINYFVATIFSQYEAIFGSPEKALEINEFFDLALPLGGILSIPFIGIILDHTSTVTVLSVLVACATTIGVLGIVEQTWAAYANICLFVLYRPFYYTAVSDYSAKVFGFRTFGKVYGTIICLSGLFNFSQSGLDYLFHETFHGDPVPVNVLLLSLGLLIGVALVVFVAVKSRSIRRKLLEEEAQSAFGTMTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7C5</accession>
    <name>A0AAE0P7C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_532927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7C5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="671" mass="74867" checksum="8B22DAAB7B75EBD4" modified="2024-05-29" version="1">MATATTTKTKPASKAGANPTSKQKTQMHRRSRTGCYTCRLRRKKCDEGTPMCTACKHLGLQCEYKRPMWWSNNDARRQHKDDIKMIIKRKKLSEKSSHSIQTSMNSPPGLSHSLPTSATFSDPMDRTRSASIDSQFAFSFNSPQSTHSTHSGHSAHEFTPFATPQIPTDFMFSPFAPYEIDVKTERQMFVNDIPTLRESTTSTFSTYQTPPPPGSILPSFPLEGEWTEQVYSERRESLTEETLNVNFFDFSHGPAMSSTRQVAIELDEGDQRLLDHFVQFVLPTIFPILESNQHGSVSSDLVLPALQNNKGYLHCCLSIAAQHYKAAMGLQGEEIDGDIMRHRYATISSLCDALNRDENHQQILEAALGLIFFQCGVGRFDDSLPDIPWHQHFQAAISLVQKLDLPRTVSDPNEPLPQSPFNMTLTAWIDILGATMQGRAPAFAHTYREKHLSPTNPSLGLRELMGCEDRVMYLISEIACLEALKKDGMDDITLCQHVHVLGDQIGLTELGEGTPILPFNSNGSLSPKQLSKNMTAAFRLAARIYLCSLVPGFYPAQESCVGLVEKLTTVLQQIPSGPTGFDRSLSWVYLVGGSVSVPGSTFRVFFEDRIAQLGELANFGSFGRAACLLREVWLQADQQALSPISAASEAPQQYIHWRDVMQMKGWDYLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7F8</accession>
    <name>A0AAE0P7F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptide-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_57790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7F8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041956544" description="Signal peptide-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53188" checksum="7E37F5D8AAA7F7A0" modified="2024-05-29" version="1">MSFCVATQSFIFYLLACTPCSNIRHRQKARNNAKKERQEKMRIVLEQPHLYQHPDPFHTNPYWSEEIRMGPTLPTKRRGGGGDGANKSTVQRGLVIPSRDGVVSEGSGSSGVISSTEVNGTLPSKPPPTAAGLNPEPRNRPTTTAPDEDAMSPTLSKTVSMSTNDDWNLKPYQREDEELWGNELSRTGQKFMDALKQASTTAGRFVESKLGIEKQVTEDDRHNFYFAPKNPPVNEYHPPVVRSKPAHKDALRWMLQPPPSAKVMEGKVPVSRSSSMISSASRRTVATSDRQSLGRLVGEKSFEAKRRKGETPNEGDFHSQVSLNRTRSRRAPTTSTVRTRSRRTARSNSLSTDSEDSYEGFSQRRRRPSRRTVKTPEILSDEDEDEYISRSLESLSNSSVPTYIAQRPRLSTIFSSEGNDKQVEKGNSISPLQEVTNASNISAVNNSLNEQQQEQQQPVEPSEDTNNSASQQVLAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7M7</accession>
    <name>A0AAE0P7M7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_57630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7M7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="91" mass="10022" checksum="E97AD377ABF5276C" modified="2024-05-29" version="1">MPIYLRLLVWGFCQAMSSLVAISCQWLALLQLPSGTTQQEPLGRAQFRTDRKSSFLLGLTEGLVEHEGLSLISDGQTQNKACQESLAINDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7R6</accession>
    <name>A0AAE0P7R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7R6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="77" mass="8746" checksum="3A932E0F713A57FC" modified="2024-05-29" version="1">MKRGLIWTLYSMTCSCYPTPPCPGNKYTISWSFNFVLLRQLPTTRLPKPYSEPERSQTKSSSLQDTETIAPEGNVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P874</accession>
    <name>A0AAE0P874_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P874"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="129" mass="14119" checksum="EF3953D80261430B" modified="2024-05-29" version="1">MLYSKLMRAGITSTRLPAFWAAKTTTRTSRPLVATQQSRRVGTILGRDPKEDMGGPGGQEALPMSNGIRRHFAIVTAAGVATACAVMYIAKLMEWNADPEAVYVLVHDNSKGELADVFQMKKQDIQQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P881</accession>
    <name>A0AAE0P881_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_462096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P881"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="136" mass="15268" checksum="BBDE740B0A9AA546" modified="2024-05-29" version="1">MTSMVPPPTFHTGFPSLAVAIAPLSMSCLASPLTGRLSLAVVVEMKKRQSNLCRMCTAELVARLLCLGSHHVKRYDRHLDTRHSSLDHASPWSPPSAVMLSDILKEAKLWRLSVAFKSLKVIAHTFLKAVKWWRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P888</accession>
    <name>A0AAE0P888_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_492093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P888"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="197" mass="21361" checksum="FBA4819A05F99A44" modified="2024-05-29" version="1">MTITVAPAIPSTAPQFVSDDAFTSAVLNSTNLFRTQHNATSVTYNETLAQYASDYLNTGDSDNDDDDACPPFEHSGGPYGENLALGCSDVQGCVDMWGNERSMYNFDDPQFGMDTGHFTQLVWKNTTDVGCGRKLCGGNRGWYLVCEYWPRGNVIGQFPEEVGRQVTGVQSAGHPTLAVGLTLQALLCLGVMLLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8U2</accession>
    <name>A0AAE0P8U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_385428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8U2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="14796" checksum="436F593C3FA4298E" modified="2024-05-29" version="1" fragment="single">MQFVRSLFLWVVPQKNVACPSVGEFYCSMRLGGCWEAVGPAGDMFKSLSRDIQELLADWEAPEDGIVGWSIYMIGPTQRSARPTLLIYGQSTVSRKSVRNLIEASKILQHYPRVGLDDCCHAPDRSHVLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVB4</accession>
    <name>A0AAE0TVB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_560785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVB4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="11953" checksum="A7E825344AF835C7" modified="2024-05-29" version="1">MAIIHTVLFQVKADTKAEDVKAACDGFLALKDKCVHPTTQSPYIKSVTGGKDNSPEGFQNGITHGFVVEFSSAEDRDYYVSTDPAHRAFVQSIGGLVEKLIVVDYTPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVD2</accession>
    <name>A0AAE0TVD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tpr repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_545264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="212"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="820" mass="93077" checksum="A35135B547F1C642" modified="2024-05-29" version="1">MVSHPVDRRSSPKKERQSPTSPIWQATIDKYYSELARSCNIQSSDELVAAINEIISQIEVLHPESVRPNTWTELLPILLGINDLVTIVIWRMGMNFKVAAVLWASFPRALPRMHIYERELRMTEALEKAMFDMYNELISPNSSRNWHTWSQFSRDFAKVIIIVQRYSRRVDKAADIIRHVQGFKHTQLRLQVVKLPYFMIPFGFKLVFVGPIGIHGLGGVGKSKLAIHYANTSMHQYKIIAWIPAKSHIEIVQAMSGLVNKLGLVEESEDDCQNVQRVRDWLNSAKNPFLLIFDDVDNIELLDQIWPSSNKGSIIITTRSPSQAFQRATITLGVESFSAETRTDISDFIRHRGYSYSEFLNVYDKSAERVFAKFERPVEYDHTPLTTFEIFLQMLSEKATSLAKLLACCHPDLIPERLLTETKAEMDGTDFLSDDFDFGDVVAELTQTSMVNRLSSSKALSMHRVVQFAVFYFDLAVKILYFDFPIPWKVRGSHQNHGWESWETCCAILPRVSWLMVLSEKHKVKSGNTTVWAKLKLPSQARSFFEFGLRIDDGHSGCIAAQAHRLLGHVHLDLTQPQAGFAAYLERAMAIHNAHDPSKMSRTLTIRAMTCLRAGEAEQALDAIRACWGLQKMTKEQNEASRYPDRSGDIMLLVYIYWLQGKKVETRKLASRTITMRRGVYGVKGGPRLADSLFTVALMLHEEGKSTRAARLLREVVEISGDAPGMRTHLARALWFLAGIEDDITKASKESRESSGTTQNSTEEKLTGPEDMRERAKAVRKSIEDREWADEDSDEGAWGLLSRSQPAKNSTRKRGLTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVK7</accession>
    <name>A0AAE0TVK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylanase</fullName>
            <ecNumber evidence="8">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_434598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090586" description="Beta-xylanase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="10">
        <location>
            <begin position="27"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="35278" checksum="D6E0CE7F2CA7273F" modified="2024-05-29" version="1">MRASLMLLLAPLGVLAAPAANEPRQATQSIDKLIKAKGKLYYGSCTDQGRLNAGKNAAILDANFGQVTPENSMKWESLQNQKGTYTWTQADFLVNWATTHNKTIRGHTFVWHSQLAGWVSQIKDKSTLTTVIQNHITTVMTRYKGKIYGWDVINEMFNEDGSLRSSVFSNVLGEDFVGIAFKAARAADPDAKLYINDYNLDNPTAAKLTKGMVDHVKKWLGQGIPIDGIGSQGHISAGGGNNLANAIKAIAAAGVTEVAVTELDIQGNNANDYVAVTKGCLAEPKCVGITVWGVRDSDSWRPSGNPLLFDSSYNPKAAYNAIVTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ16</accession>
    <name>A0AAE0TZ16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_393450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ16"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="383" mass="43640" checksum="2FBB096B0B856E94" modified="2024-05-29" version="1">MDYRPHYERRGPQIYVHVEFGVSWSRKNVPKNHEMTYKSRNLRERPFPRQVPAPNTNYLAAIRAFEERQKRAQQGRHLHPNTHNHAHHNHHNHPNGHHQMQEYYQAGYLARGRDQRPVGHEQTRQTRAETGPSYERGRSAPPPIGENPWDVSVQQRQEVIQQSSRAAEYQQQPDQMKALPAEPSQYRLGEDGLPWSAWAYPEGYNPDSYPQDDEQEDEEEERMSAHAVPGTHRHETYATSPTMVSVFSPGPSLMEPHFDEPTPIPATTSAQATTKGRDLGALSAAMMTVDNGFENQWWYQGGRETVSASEPPQSPTQNRFSIGSLPEPADEDEVEDLNSFAVAVSHVSPLTGSPRSTFLSLTRTMSTRSEELWLSERGRMGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC4</accession>
    <name>A0AAE0TZC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_180505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="38242" checksum="2DA51CDFA21DBB41" modified="2024-05-29" version="1">MADAPEPTPSAVPGPAAAQNTAIEADPHNELEEGDDDVSEYGASDTSSLGSSIYKYRVENGRTYQRDGTYFMPSDPHEKARLDLQHNLCILMQDNRLYISPAGKNKPLGRVLDAGCGTGIWAIDFADEHPETTIIGVDQDAALPTYVPPNVEFLVDDLEAEWTYGRPFDFIYMRMLCGSIKDWPKLFNQAFTHLTPGGYIEVLDPINPMQSDDGTLPDDCAVIRWNRLLLDASTQLGSPLDSARLYKTQLAEAGFVGIVQTEYKWPMNSWPREKKYKDLGAWTYENITAGLQALSLMLFTHVLGWTPNAVEALLVEVRKDMKNRNIHSYWPVYTIYAQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZJ0</accession>
    <name>A0AAE0TZJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_472892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="86" mass="9083" checksum="3D80215ED4A91826" modified="2024-05-29" version="1">MAGEVVEAAMAVLGLLIMVLLGWVVVLVLLLLLLLLLGHGGWLVESSMLLLLLLGHGGWLVESSMLRLLLTIAATAIVAVLFLICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0I5</accession>
    <name>A0AAE0U0I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0I5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042097364" evidence="1">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="30058" checksum="0F4E060F53BF26D0" modified="2024-05-29" version="1">MHARLLTPSWLALLITGSLLVATARAAGCAADNCARAVTGTRRGAAAQASAKADCNSFMAKTITAPAITITSIVTATVAPAASAPVKRDSLATPAYASACSGASRYSSACSCWGITGTTVTVIPTSTAAITITAIPSPATTYTPDIPPSYTNCVFNPDAGTSFDVLAPANAGGLPIVKNGTLAVVSSATPAPVRYKAIKPLATPRGVYDIVLDTPSTFPTQFLAIFDDGAVGFTTVSSKSQQFITSEQGRFITSVFSFTCDGRITAGIVGAEEFRFAVAGDGKVLATGTETLRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U171</accession>
    <name>A0AAE0U171_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAPA-1-like conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_521310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U171"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="3">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="443" mass="47689" checksum="E24617D68DCC312F" modified="2024-05-29" version="1">MSSRPRRSAAQRATVAITDMADRDNERSMSSRSRRSGAGAVASVSRGPPSSPASSPAGASHIHLTVKMPSSKLRQATNGSSKRKAPSTPAPATSRGPYGRPSAAAAARTRGEEEDDDEDDDAEEEEEEEEEKDEIEVGDRAGLVDVEDEEEDEEDTHMDLAVDDAEGEVGEMDVDAEGEEDDDADADGDIEMATAPPLPPPSIKVSKPSRGIATLIKGKSTPSKPSSKGAAGTKAAPVVDDDDEEEEDDDDDDDELSELESEPEEINDTAAVGEEDAEGEEDDDDAEGEEIEVADEDAEGEEDEELDSDEEGGSRAETPDLTKLTARQQVQAKKVFTAEELSMRRAEMARRRRNLSEKRNEEVKMETINKLLKKQAPKTNKRNIGGDTPDGEHARADPLFVRWISTKDGNRVAVPDEMLVSPAGRIFIKGGGLMAGKMVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U198</accession>
    <name>A0AAE0U198_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_493614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U198"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="308"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="50436" checksum="67FC986025EC525D" modified="2024-05-29" version="1">MSWRKSDKLMDMIRHYASFPATGVSLRQMVQFGEKPSTGTLFRASQFLAEELPIRLAHRVQELDTLPDGLNEMPSVKKVRDWYAQSFEEITELPRPDLGREVKERLLKPSKASGKGLAWLSEATPNPSIEEGQYNSWTGVSQQNGVGNGWGKKFPATRRYFAMVDDNGDWPPDLQLYNQRFAQTLHKIKRRHDSVVTTMAQGVLEYKRKRQRMQIDTNIQAFLDRFYMSRIGIRMLIGQHIALTDQSHFRDPSYVGIICTKTYVKDLAQEAIENARFVCEDHYGLFEAPKIQLVCNPNLNFMYVPGHLSHMLFETLKNSLRAVVETHGQDKEEFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDRTPNLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1T2</accession>
    <name>A0AAE0U1T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_470028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1873"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1983"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2048"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2065"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2082"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2132" mass="236415" checksum="82A41398D32106BB" modified="2024-05-29" version="1">MSQLSRRSRDNATDLLSLKEATNARDEDIRKSLRELITDAKHAKSSTRDSYGGPLLLEGRHHPTSPTSTFSKTARPFALPRIPSPNSFAASLDRESIMSTPSLYGPESPAIVALLEKIIREMGTREGQDSLLSRLTEVAEKLSGLAAADKVEELVRLVKSNPQHAVIPAAGGSGGGGGVRDRNWSFTEDDDGARGRDLDYDQTRAMANHVGRLLQEKESRRSSAPASNASDVLNDDVLKAIRTVKDSVAAGGGITAEVKALVRELRGEVLGMGRELGRRLNEVVAENGNKEETPSKAEMIRVVQEGLAEMQQQMSNVLREHRRQSAATVASRESSIDYKEIYNSMRAALKDSQANKPRQPELRREDVVQAVKDAWEKYKPEIEIQQIGLERDEILECLQEGLRAYAPQDDREPGATRDEVFQAIVEGLKHFVPPQVETPVTLSRDEILDAVRECLEEFEFPVAPTAPGAKEDMVEAVKEGLHSFNFPTPEPPSDLTKEDVLDAVHHGLHSFDFTAAHSSALVPQSLSKGDMSDAVNQGLRSLDLSADMLDAVREGLDSVNLPRNMEKAVQAGLQSFDFSVLSSAIVPRSDLNRVDVADAVKEGIDSLDLPSNVTHAVEEGLRTFDFSSAYSSALVPRPDISRTDVVEAVREGLESLDVSRDVAHVVKEELRSFDFSAANSSALVPRSDLSRVDVVDAVKEGLESLSIAHGVEDAVKRGLQSFDFPSAESSALVPQTSNGEEIVQRLYEIKDFLQAEFKAVSEEAKQNIAASGRDTEQVLDATKDGFEKLRSDIETYVDRATGESGQEEFMVNLVRTLDGFRDEVADLITRSSDGSKGILTEDIESLRDIVNSSMVPAMPQTGSHKEVLEALQEGLSGLRSEISTRPIAGLTEILDALQEGLGDIRGSIDRLHDKPADLTANDEILDALRNGLDSVRSDIDGLREESKNDRALAPISDNAVVPLEDMAKHDDIKNLEVLITQLRIKLEAIESTPPPAVDSLTKDDLAEMEQALRNVAESVAGIPTREPLEALDDRLRSVQETIVEMAAREQNPPPPAERPMTDPASREDVQAIETILRNTKACLDDLIDGEQAVRKDHIDILETLILETRESLTGISARMEVISQKEDVTMVESLVTQVISSFDDMKERHEKAFEDPEKVTKTDLDAIEAVCLDMKSDIDQMVKADLAALPSKDDILALETLLREYKDRIDVHADTNAKAFEERQVELVGVGERVTEVKSFLEEFQGVMKVRLEDGAKGIDAINGLLDSMNSTIQKNSEIRDDLKEMFDTMKLEFEESKAGVVGAKLEADDKFQITTEIISAKLDERISELLAKYDEIQLSHEERAAKGEARDLEMEAAAVGTKAVAEELKSLVDTLGTAVTDSLEKMEEASKVVFERVEDLVSKSDENHSDVKVEHQLTRDQVQEAIGKVEGLQGHVAEYQPKILETLQDVLLVVGQHYEHSKSSTVTIQEKIEEAKPPEQPLLPPPEKYDDSVVIQKLDQLVDHTHHADKALAQLDTLDKVHAQVKQTATELAVFIAAQTQRIADVHEDKERTLQETIVALERRLEEKGHVEAHVANLREEESYLRETINVTLREEQEQMKEQFLSNLRDEELRLREMVNGLKEEQDQLKETFVANLKEEQARLMDTNVALKEEQNQLKETFISNLREEESRLRGMNGILREEQQVLKDTFLANLREEESIIKEVNASLRVEEARLRENLLANFQDEEARLREANAVLRQEQEQLRVSLKEEHDRLKAELLASLIEEEARLKQANAALREEQEQMKAGFMATLKEDEGRLKQGLIELRDEQDNLTRQKIRLSAELSSLDTALRLRREDLRDMEERAEGLERRILEGVMDHSRVLLMAKTNRVNGRESMSRKRVSSHHQKPAETTIPTTSIPTVEITKPRTAINMAMSAKSKVNAPSPLGASRRILSLSQITSNVPTGGISRSQSVRTAVGPKLRKSSWAGGPTRVPAAKGYGDLDRDTDKENIVLKEDDEENDNSFNDALESTPAPVDIFAQAPESIVDSEPSNEVRHIEDAHHDAEENEVSDAETETLRRSSRGTTVISRTNSYTGSEDYSYDEDDDDAASDWTESAAGGPRSSYDGSESNLGSSVAASESGDGQVVLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1W7</accession>
    <name>A0AAE0U1W7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_413117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1W7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF10">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="311" mass="33993" checksum="140C4E0A54E8D931" modified="2024-05-29" version="1">MSSTPFKKIVLVGAGGDIGRVVLQALLSEPSFEVTILQRASSHSKLADHLNVVTVPDSYPFDELKAAFQGQDAVINCTTTFSVAVQYRIIDAAIAAGVRRYSPSEYGLNNARLEAQALSEVFAEKGAVQAYLKQKAAEGKIEWMSIACGTWVDWSINHDFMGINMKERRVQLIDGGETRHSVATQKNTARAIVVALTTKTEETKNRVVYIQDFTVSQKELLAELEKQTGETWNGDVVDGKKLTEQMKAEAKEGKIEAKVALINIGLMSGDYGSFFEKEGEVLNGTLGLPKANLAEEVAAGLRQYREANNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U210</accession>
    <name>A0AAE0U210_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone chaperone domain CHZ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_521701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U210"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="12661" checksum="7C92A78456E9D35F" modified="2024-05-29" version="1">MTENGATTTSAAQELAAENSKGKGKAPAQEDVVKDTEMGDDDDEDDEEEDNDEEAEVADEEDGLEEIDLDNVIGRRTRGKVIDFAKAAEENPAEADEDEEDDDDFEVEDEKMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U343</accession>
    <name>A0AAE0U343_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_463240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U343"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="222" mass="23687" checksum="B43E4044C0B42BE4" modified="2024-05-29" version="1">MVSSKANDPNTSSEPPAPNNPRSTSPKSNEPNSFAASSITGTTIYGGGDGVAEPKPGQQQAQLAESLKDFRFPEDKNTGNGGGNPDDPTHILITAPSNSTLQSTNNLKRNVTIENATGGAGRGPGTETLLKKGQTKTIKLNSAPSSNKSKNSKLKKLRLLPRRIVGRLRRLSSRIKTRAQKRKDKMKPSGALKLKMQLEEPMQKVGEVSEMAGVPKPPKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3B4</accession>
    <name>A0AAE0U3B4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_97085</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042290103" description="Mannan endo-1,4-beta-mannosidase A" evidence="12">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="13">
        <location>
            <begin position="62"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3389317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="371" mass="40710" checksum="5E02E42AB8D35360" modified="2024-05-29" version="1">MMKFVFALGLGLLSLAVALPTVTLADAKPPSVNGTRFTIDGETRYFAGTNSYWIGFLTNNKDVDTVLSNIASSGLKVLRVWGFNDVTRKPNAGTVWYQMVSASGSQINTGSDGLQRLDYVVQSAEKRGVKLIINFVNYWNDYGGIAAYVSAFGGTKENWFTNEKAQAQYKKYIAALVSRYINSPAIFAWELSNEIRCKGCNTDVVFKWATSTSAYIRSLDPNHLITLGDEGFGLPGGTSYPYQTSEGVDFVKNLGIKDLDFGTYHMYPSSWGVQNSFGPGWIRDHAAACKKAGKPCVFEEYGSTTDHCSVEKPWQAASRDADGNAGDMFWQWGDKLSSGQSANDGHTIYYGSSDATCLITDHIKAIRAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4D7</accession>
    <name>A0AAE0U4D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_446344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="369" mass="42176" checksum="905A37B9823B4FE8" modified="2024-05-29" version="1">MQQGPQGPMGQPTPEQLKAFHEQLEADAKKHGMTKEQFIEQLKAQQMARMQAMQQQQMQQQQQHQHQHDHDEQQQGQQQPIVPGPPNPVALLLANFLRSQKLKPRTCILNGERKDMFKVKRALRALQSPEYAKARKKNPSLPEITDRASLENTFKLLPMSMLALRVVKSDPHEGHDHGPTPKKGKRVKGLWTVKIEPQQEAKEEMYYVWLWEGSQLMRKVYAGLALLVIFAVVLYPLWPMKLRQGVYHLSWAFLIFLGLFFAMAIFRVILFCITYFVLSPGFWLFPNLWEDVSVVESFKPVWAWHDPNPKKKKKSKVSSSANANATFSATTGQPAPATATTTATATQVAVEPRQRQYTAPRVEELSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4Q0</accession>
    <name>A0AAE0U4Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_113030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4Q0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="225" mass="26413" checksum="3BAD329D508FE447" modified="2024-05-29" version="1">MATKDETKEEEPVDTRDALDVLETEAKEFEKDAEISRILGAFRLDAYAVLGLKPGVPESDIKNIYRKKSLLIHPDKTKNPLAPDAFDRLKKAQTELMDEKHRITLDEAIADARMLVMRENKWTVDSPEIKTADFDKKWLEKTKVVLIDNEQRRRRQMKAQLQEEGREQRRVDEETEVRKRKRQHEEDWEKTRDQRIDSWRTFQKGKTGGGEGSDKKKKKKLKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6W9</accession>
    <name>A0AAE0U6W9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_14022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6W9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="112" mass="12306" checksum="9D53F81295059755" modified="2024-05-29" version="1">MPTVLGGCSITTLLLLTSMTCVSVSLQLLLIISPSATLLKHGVLIAETLNPILLILFPHWFSITRSRLFLGRVRFGTFRYLFKIRRAGRKGLAKWGTPPHRLSPPPPAAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7G1</accession>
    <name>A0AAE0U7G1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_29068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7G1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="245" mass="26460" checksum="A70012206A4D9590" modified="2024-05-29" version="1">MQQKGVIRKKVLIWKGGGMKKLLSVSLAHRLPVGSSVAVTSGRGRRVWEGSLSRNMPLSRREMPRMRIIQIVRVCRKSLPGSPCHALPLEPPSESPFGHGLGSITATVACLVLPDGCFHGLAAVTDPHFANQLARSVHRPQATGPSDRLPRAEAPVDGSLTSLAAVDENAEEVLSGLTACCCLLHRHRHCVQKKKEKAGNHCRALQREGGIMSAWAFSYPPIMILLVGRGFGQSSSSCMYAVCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7K3</accession>
    <name>A0AAE0U7K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_16499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7K3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="244" mass="27227" checksum="B289D878A5B51F6B" modified="2024-05-29" version="1">MSRECRPVPKPLHAPYVLASGSFVPLSLSCLPLALSLLTDGLVQTKSKFRSKVPNAECRSLTRRWHLSSPLSSLLFPSFDYTDLRPRTDTNLPSRLLLEWHLCLLAGPARLFSTTPERVVPSLPLGRKRRQKHLPHRAEGTTPQEKAAFAPHERVTPPPPPPQLSFHLSFTFRTASLAPDHAACSYPAAYKYGQVTLPRPRPPRQRATQPWTTPSGPFPQPQTSTFLLATTQTTASTNSCRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXX9</accession>
    <name>A0AAE0JXX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="24285" checksum="0A7865537AE7AB39" modified="2024-05-29" version="1">MEMEEELAKAQAEHEAKAQAEHEAKIAHIRAKLADLEKEKEKLDKAQRKLDKAQRNLDKKQKMRDNWRARRNCRALRATSNVTDSHVRVADIDAKVWPEYFCRYEKWNDERGASDYVVFFVPCGDIWALWVGNDIPFEQSVHLQDGTQDGTHTIPNIAGAKGWWDEEWEFYQGLVVQKPYPTRAANTAFMCAAIAEQVGKGEGFYENITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZZ9</accession>
    <name>A0AAE0JZZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_82829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3367491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="323" mass="34618" checksum="EDEB9DB4D82530AA" modified="2024-05-29" version="1">MAQQLDPTAEKAIGQTTATAPGVNGANAAHHREYDFHNPMAHIHSNVNETRLPAFGGEFQPGLWKSVEARKFANPAPLGLCAFALTTFVLSAINMNARGMQTPNIVVPLALGYGGVVQLLAGMWEMAVGNTFGATALSSYGGFWIAYGILLTPNWNILGAGGPYATDAVKAIDPKMGESAVGLFLTGWFIFTTILLLCTLRSTVMFFLLFFTLDIAFLMLACGAFANDNGAMESAKKLTQAGGGFGMLAAFLAWYNAFAGIADSRYVFFLFSCSCYGILLKCTLPPKSGGSHLIAKQAMARHLRHTHCGSPRCRSFALTLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K001</accession>
    <name>A0AAE0K001_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_535491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K001"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042042575" evidence="2">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="322" mass="35762" checksum="4A3B026CD829482A" modified="2024-05-29" version="1">MSGLVAAVDLIHFAIGLGLDLSGDVLMFHGVCDTLFTSSDPNSLASKLHEISPDTEPPDQEQDTMIRISLFHIDLPVSRTSFSALAPQWLEDDPAESYQLDSYELAFDRKGRINLVKVAQCDSYQAKQLSDVGYRLAKTIEPLVEVVKVSFPAGDEYDEAKAKFTALEPVLRAFCREIVDRHERISNDLNDHPKFLELAKDSRFKDLGVLLYDFFGVVVLLGAIVAILVLVLLLAVFVKDKENRFRENSFYEDYTKKKVPGFLVPAILIYGGLVLSSFIVSMFVDVDGSRILGYGTAVALVPVVAVLLLLLISIRFVRGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K048</accession>
    <name>A0AAE0K048_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_455655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K048"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="272" mass="30466" checksum="444F711610B19212" modified="2024-05-29" version="1">MKLQPLPTSLLVIGTFGSANGTVPGASRANEAPTAGKKYLALGDSFAEAIGAGRFIDPNLLPDGENHNRCARMDGSYPMQFLPMMKDLVADPIDFFACSGDKLDNIDNQLNKLTGNTVDIVSLSISGNDFFFNDVIHVSTFTRGGAKPAQEVCDKKIEFSDWAIKQEETWEKYRAKVKDMRNHNPGGKIYITGYARFWSIDMPPSNDDECSRKKLFHTSSLFPDWFPNLLKNRIGTLMMAARNRRLMNFRVLDINDRIGRQSFEARYPIVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K296</accession>
    <name>A0AAE0K296_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_488938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K296"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="82"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="517" mass="56684" checksum="FA2821CB5D945A01" modified="2024-05-29" version="1">MAGPPSLLPSTEKKVVTEDDSADYDRSAPTAAPSGFSAWVFGGKGVTIGPRIGPVLPNIPVDIVEVDKQIAIEDGHTIQYRTCSWQKTAALLFSEYICLAIMSFPWSYSVLGLVPGLILTVAQAGIVLYTSLVLWEFCLRHPEVRDVCDIGQMLFWNKKWAWYATAVMFLLNNTFIQALHVLVGAKYINTMVSGDDSVHCRTVSFSIIVTIICWLCSLPRTFNMLSKIGTASAVFTFISVVLAAVFAGVQMHPAGYDLATTGEPIVTAIPIAGTTFVAGLNAFLNIAYTFIGQITLPSFIAEMKDPRDFPKALWACTIAEVIVFSIVGGVVYAYTGNQYMTAPAFGSLENVYKKVAFSFMIPTLIFLGVLYASVSARFIFFRIFGQDSRHKNEHTLLGWASWTGILLVTWILAFIIAEVIPFFSSLLSLMSSLFDSFFGFIFWGVAYFRMRYADKRGITLVKQRTLSGYLMAGINIIIILIGLFFLTAGTYASVEGIIEQFESGSVGSVFTCASNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2U5</accession>
    <name>A0AAE0K2U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_497767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="302" mass="34347" checksum="3CA75C928002464F" modified="2024-05-29" version="1">MKHITRTKGTKAALSMWAGQERLAIASYYFWSAGATLQKSLYGLLCSLLHDILDQVLDAIQKVCSQDFFRQRGYPHSVMKWSLSGLQKCLHNLSIETKLRTRFSLFIDGLDKYQGDHPEICKILEDLCKSPDIKICTSSRPWNVFENSFGNNDRLKFYMQCCTQDDIMGYATDRLHGHPRWSESCLGSPTGAGDATLVDEIINRAQGVFLWVFLVAHQLREGLTNDVTADDLWKRLESIPTDLELFFKQILESVDHFYHEKMAQTLLVAVQHVATGIPILIGILAFHDMESGNPNYALDQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K393</accession>
    <name>A0AAE0K393_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_488782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K393"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3368596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="486" mass="54337" checksum="BEF2AFBEF2CDAB79" modified="2024-05-29" version="1">MAPKTKQTAVAEPAHGYEFFGPPGAFGISFGLPILLYLFNFACNDVSGCPAPSLLHPKSIDFEVLKKEVGWPEDGVRGLLSWDVLGWTLAYYLFSAVLYRVLPATEIEGTKLANGGRLKYRFNAFASTVFTLVVCAAGTFQQGAEFPVWTFMSDNYVQILTANILISYALATFVYVRSFSVKDGNPEFRALAAGGHSGNMLYDWFIGRELNPRVTLPLIGEVDIKEWMELRPGMLGWILLNCAFVAKQYRLYGHITDGIVFLTIIQAIYVLDGQYMEPAILTTMDITTDGFGTMLAFGDLCWVPFLYTQQTRYLAVHPQSLGFVGMAVVGSLLAVGFSIFRLSNSQKNAFRNNPNDPKVAHLKYIETKAGTRLLVSGWWGIARHINYFGDWLQAWPYCLPTGLAGYTILSAGSNAVGAHKMLDGREVIAGEAQGWGMLFTYFYILYFGVLLIHRDGRDDEKCSKKYGDDWETYKKIVRSRIVPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K588</accession>
    <name>A0AAE0K588_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_486826</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000090">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1356"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1387"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1418"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1463"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1242"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1590"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1618"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="865"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1021"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3370344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1659" mass="184963" checksum="1F55C53C2EA55B76" modified="2024-05-29" version="1">MAGRRNRDALDEDLDPAEFQGHSQQVLQDPRAPSSSPRPGSASHDISSAPTAGVNLTGFPRAPLPRFSLSPAAARSRPPRTSLYTIESHTGFESPALEEPPQVPDDSASRDHRHGVRARRDDQSPFSLNPPRKTFDDLHGSVKSAMATAEETNATLSHYREWVDRQKKNQSRWGGLSWGAFPDRAKAAYSRVILKGLLRRKAIPPSKDGRRIPIEPGLARRKPLRDERTGRPYVSNLIRSSRYTVWDFLPKQLFFQFSKLANFYFLIIGILQMIPGLSTTGTFTTIAPLIAFVALSMAKEAYDDYRRYKLDKQENRSVAWVLDPDNAHTTERRGLPEFLKREKSGGTNVDVQMTELEDGARTRSGQQTRWAKLEWQDIRVGDIIQLRRDDNMPADIVLLHATGPNGVAYIETMALDGETNLKSKRACPLLAKHCDSIAAMASCDAEIVTEDPNLDLYNFEGRATMNGETMPLTMNEVVYRGSTLRNTTKAIGLVINTGEECKIRMNGNKNVKAKAPEMQYRVNRIVILLVGFVVLLALGCTMGYIMWRRNYEHRAWYLYRSTVPLTNIFVAFVIAFNTLIPLSLYVSLEIVKLGQAYLLNDIEMYDPVSDTPMVANTTTILENLGQVSYVFSDKTGTLTENLMRFRKMSVAGTAWLHDMDLQKEAAEIERKRKPSVYQDVGTKAGKGHKTSSPTSTTRFAGAGAMDEHGAEEDHHHGNAHPTRIGSISHWKSTARPGHAQPEMKTEDLIRFLRLKPNSPFSRKARQFILCLALCHTCLPETSEDGEVTFQSASPDELALVEAARDLGYLLVDRAAQSIKLQICDADGSTVTETYDILDVIEFSSDRKRMSIVVRMPDGKLCLFSKGADSVILPRLKQSKLTTQAVSAVSRRASVRKSLELEKALRRQSLNSVKRESMNIIRAAGSSIDRRDPRVTRKSAVFTGEVASWLEQRENDGLGDELQDDDIYQTPRASMARGRSMDLALADDSYDAVVDEAIAMNDAAVFERCFQHVHDFASEGLRTLIFAYRYLEEDDYRNWKTVYHEATTSLVNRQERIEAAAEIIEQNFDLAGATAIEDKLQQGVPETIDKFRRANIKVWMLTGDKRETAINIAHSTRICKPFSEIYVLDSALAGWEEHMADALVAVGRGMAPHSVIVIDGHTLGLVEADEVLRALFFDLAVRVDSVICCRASPSQKATLVRYIRHQVPSAVTLAIGDGANDIAMIQASHVGIGISGREGLQAARISDYSIAQFRFLQRLLFVHGRWNYIRTGKYIVGTFWKEVVFYLVQAQFQRFNGYTGTSLFEPTSLTVFNTLFTSLPVILLGILEKDLSADTLIAVPELYTFGQKNKGFNFKQWLGWMFMAVSSSVIIFFSVYCLYGTSHYPVDTSLYAMGTLAFSLAVIFINIKMLVLELHDRTVITFSGLAISVSGWFLWNVGLSLIMPHSPGPYVVRGSFTRRFGRNGLWWLVHFITLSALIVFDVAVSSVRKSLWPTDQDLMQEMEHIDGIMDVMREHALEHGDTSSTYPLDDRVAAGLASKKGGDDAASIKSMGASSAASFTSPEHMAGFHFGPSRSTSVVSKRGSRYMTEEVYIPPPFTPPAEERENPMDSGAGGGGCNKPTTIPTITEPLATQSGQPFHLTQSPIELQTSPARRKPWPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8L4</accession>
    <name>A0AAE0K8L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mating-type protein MAT alpha 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_282683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3371914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="35552" checksum="96E7FF0A520BDC8C" modified="2024-05-29" version="1">MSVVNQIVQTFAGLGYDDREATMKVLSGMMRDGSQHQPKKKVNGFMGYRAYYSVLFSQLPQKERSPFMTMLWQRDPFHNEWDFMCDVYSTIRAFLAEENIPLQVWILHAVDHLGIVARHTYLDTFGWRLVQLQDETHSLQRTTTSEVRHRLQPINGLDLFLACLANGLPVSNPQPIITKLSDPRNDILCMNHGSLISSNPSRLMNLDSLGRRNTDPAMKPHFEGLTTEPVIPQRATVYENHNSHRDIVQSTQTDVQMSSVDSFSMDDSSSGAMVHTILEGDDNTEVETETGPDFFNMAMVPGAGAHLEEFSDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K940</accession>
    <name>A0AAE0K940_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_293069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K940"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="14298" checksum="5FDA497F7E01B92F" modified="2024-05-29" version="1">MPPPPSHGAPGQSNVDKLKMGAMMGGTVGVIIGFIFGTATWTDGEQAVSNRLTRAVGTVNIFRYGAGPNGIMRTLGQYMLGSGATFGFFMSIGSVIRSDSSPIIQEAYLRAQRRPIVMAAGAFRPYSPHSRSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K967</accession>
    <name>A0AAE0K967_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein rim2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_294048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K967"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000079">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="168"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="284"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="41425" checksum="176E831290B8679D" modified="2024-05-29" version="1">MASVPATRTLPGSHTDKNGPRDDLPLLQSRETGELIPGTLSDVKEKVPFAKSWAHFVAGGIGGMTAAALTAPLDVLKTRLQSDFYQAQLAASRAAHGNVHMNPLRTAMYHFNETGQILATVYRQEGTRALFKGLGPNLIGVVPARAITFFTYGNSKRLIAEKLNGGKDTAWVHLCAGITAGIVTSTATNPIWMVKTRLQLDKNVAAEAGSIASRRYKNSWDCIRQILRDEGLRGLYKGMSASYLGVAESTLQWMLYEQMKRSLLQREERITLSGRPKTWWDHTVDWTGKIGAAGSAKLVAAILTYPHEVARTRLRQAPMADGRPKYTGLLQCFKLVLKEEGMVGLYGGMTPHLLRTVPSAAIMFGMYEGILRLLDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA51</accession>
    <name>A0AAE0KA51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_289401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="363"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="70536" checksum="075CFE5BBDAAC343" modified="2024-05-29" version="1">MNLWSIFPRDIKLQILDLVAQDHYKLEPSKRVDDRTAGYATVCKEWQEFFEKKNFELIDISRGSRLLKFKDIVQGPRRRYVKHIWLRIVLPLSGCRNWSGEPGWPNVDNWSRDRIYIYHPMVHMLFKELSTWNRATDLNVEGDLTLEFSIYSSRDSERLAKHKDFGHDPYRPPGRDDKPFITWPLSGYEPGQTCASTRDSDNFWKDGVRWDTRAYDPQTRAMACRRAETLISELLDKPKAYSLESLRSLAYEYSVACGDSDSWFPKSDILPTVDVVTRFLVRRQYYRSLTQDELKVIFASLVGLKRVDYEFWRKPGHEDQMEEMGRIFISGRHSLSDTPLQPEEYCKLVLSEYLKDSPFTSALPRRTESLSLFEEFSEEFAILTGYPYDRRMDLMLGLALAVRSLDLKHCAISGWIDATHFFTPFWPSPSEFPWARDYLEKLVVRDRLSYKAVQSWIWDKLETLALTSQFLHSAIEERELNKLLEATALAARHMPKLQVLEIWNHKVDEASIFRYKKRADRVGIVSWQSTYEFSMSEETKKAWSELVDHVPDLHTVHVTPSETLGGSFSLSAVLSCLELRDRIVHPVSAHQIRVEHETMTWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KB19</accession>
    <name>A0AAE0KB19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_301826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KB19"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="653" mass="72629" checksum="E0AB9219BC794EEB" modified="2024-05-29" version="1">MGASQSTSFGAQFVGEGLPVFRSYQPCHVFGDSSLYSVGTRLGFYLQYFAVLLSILFFRGQDVKTWFLCFLPLAAANFTVLLVSANAGDGLIVLDWAIVFGLVVWSIVFLAWSVFSRHNLRSSPGLATDTIQLQQDLARESGRMVSGQEAEWDRQYIAVLMVLGSREEEERGRRDSWRGDPVDKQDALTAALQQYVDAFLPARGSPDSADAAYLISTYYDSDRIQDTVASMMMDNRQVGIFRDTHTEALRQANIPFNQAQATTQILARMAKEELKPRDPNQPARSTWQAVKEFEEWAGTAGTLGCGLGLVLYGGYSIFMIWLLFRGIGNGAKSGCDIRIILFVAPVSVYNPGAVTALRVLACILFVVVGMPALLLGIGLFVVGINDWWSDVPQRRRRSSNNEKRDRTGFISIAYDAEQGRGAAARSSGMPRHAHSVSIPRVSRTSDILSDASLYRQPSASLATERRGSDFYFDPALKETSVSDPVLGMRGGLATGGTSVLQWARGWIPAKRKWWAPFFLGLAIVHTVVVVELTIRINKLDMRQRPMTSMGELIAFFLGLFLFVRVVARCLLAAEKRLRRRRAAGWFDERWRILAAPAERWQDQYGVGAVPGRSATGESRQRESTVLRQSRIYLQPEGKSRSSMGKFKEIMDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDS3</accession>
    <name>A0AAE0KDS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sh3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_496305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDS3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="934" mass="103961" checksum="972A5AED9E9D0BCB" modified="2024-05-29" version="1">MTRPEIIRADTIDLQARDGPTAQAHHKPVPDALGLLAPHQAETLREVAAETAEDQLHSPRPAWNGESSDPQQLQQKQQTGPNTMQAGSQQDALAIAQNGGIEADDDLDGETEVDMDDDMMDKISSSPSIEDGEKSSSMNPKLGDDHNHFANDGNDDNTSAISTTPLHRTEPRAIEEWPPGRALNGTNDHEVETDADVEDMFEDRLPGINEHVTNDKCREDEIYQVYEYDEDYDDGDDFPIEDPRFRDSGWGDECLQDTEDIDFEFVYALHTFVATVEGQANATKGDNMVLLDDSNSYWWLVRIVKDSSIGYLPAEHIETPTERLARLNKHRNIDLSQTMLGDQAEKSRNPLKSAIKRRKAKTVQFAPPTFVDYSDNDFSSEEEDAEAEYFAQQQQQLATQAAGDAEIEDETAKVEPLKPRLQLKEAAPETVRQEAGVETDGMTTGKVGIRNSEEIFETKAGDGPKKTSDGTVRDSFFKDDTVETRKITLTPNLLRDDNAPRTSADSRDLKQRVSLDKLDKDSPPGKDDKKKRDKKEKEKKPSAFRSLFSRKDKKAKGEEDDDSFGKPSMDVDYQDREMEEEEVQASPEKSQGPQRNPSKLQKQQPRIEPSPTRKSTITSPKDSGMDIVTILSEGKVNNVANVPPASMRIVNPGMKESPEGSPRDQRVNRDQSPEATRTDDKFGAPRIAMSRAPAEDVQPQKTMQAKSRVELDDFDSDEDITPQPARQAPIPEAVLRQQQQQQQYYQQQSQQQRSAQSNFSDSYQLSQSAPVGPTAELGRSVPVNTTPPQQHVERLSESPIEVSPISNPPPLMGDTSSQEEDRSSTRSSPSPDLIEHDDGDTLANQDSMTTSTSTATASTWNDVNLRAFFDSGSDIRDLLVVVYDKSDVTPVGPEHPIAGTLFKEQNAKLAEITTQLDNMLGDWLARKQRLRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDU3</accession>
    <name>A0AAE0KDU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_255643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="29943" checksum="9CD0BD059F3C247A" modified="2024-05-29" version="1">MVKHARQAVAKDAAPAVANEADSTTAVLRTKKSTTRSPSTARADDSIPPAIDADMGDMIDPYDSTMSTRNLQTIMPIRSPHDAQRDLVTPILEAVLTRVENFESVAQHEVRETLGHILLLKENLDSREAELGPNDVANRVMLGVCQVQVKNLRLGLENITKMGTPTTELQGMLYILNNHKPAPAVVGGPYQACRCCADLLADAILIGDRFFTIDEIAKLRKFREFIHARFQRIFQILTSKDWEHSLPYVSAMLRKLSYTFSNSAKLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE77</accession>
    <name>A0AAE0KE77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_267026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE77"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042236640" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="8878" checksum="DA8A2E01E423AAE1" modified="2024-05-29" version="1">MGSPVMAPFALLYLLPFCAPAIAIARREFSKAGAGCQVTDRCLCFTYPGPLAQPSPSYPSFLSSTASKPASFAQSQTPFQLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEJ7</accession>
    <name>A0AAE0KEJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEJ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="640" mass="72030" checksum="D276B6EC0AD6FB4A" modified="2024-05-29" version="1">MCSETSISTGSTDETCTEKSTTRQSWSPTWITELPREVMADLRAVRWRRACLWALFSIWTSGLFLVTVALPLHAPNSRSACQPDGSFNLRPFDYQPWSSAGFFQITIAFGELTFTQAKVIDVIWDVVFGRVGQAILAFFSWKAFSMYSKAFMGTGSLTYDTFWAIIMQNGPSLRSTVHVIRDFATRKALQSKLAMAFIVSSMLFILGFPTLASSMSGYASNTGAFVADMEGTLVPFARFIPVAYVIHDGWRVNLTGDYIVPYVDSPVSRSGPIFGYNNRFYNNPYAYDSAFICNPTNMYPADLYSNDTNGKLAACNLSLGVSDYVRTYGFLSLNAEGKVNDIETSWMHQTIGPPALNISGHYFHEDNDLRNWFTERFGFFGHTWTDPRTGTRPYSNVSNLAFVEVGKNYTFTMDSILRSGSCQALLTYSWGFSYVQLWMMILALLAWTLGTYTLWLKAHLTLATRVDHDVPYRYKAALNLVSAMRGQLDASGETAAPGSWSSQQLTRYVDTHLRGGKITEESVLALGGNFSFRKGLWTWIKQHRKTSLMMAVLIPYDLLFWILILDRGPASEFLIAPMSAINLRAYHLVLVPLYLALLCWSIGFPLSMMVGSSKRTRWFFLFCTVVVVAGVPWIAVLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KET0</accession>
    <name>A0AAE0KET0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_400437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KET0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="522" mass="58743" checksum="4E990E2D0AC443B9" modified="2024-05-29" version="1">MFLQLAVAALALLGPYLYAKLRYKRFKQFAIFPQMPPSLLWGHLQKLDVFIKAGPPNGHPDLAFVAMHEALGRPPIVFADMRPFMRPMIVVRSHEVAEQVAKAYPDKLLPYGMPKMPEIYGHMIHLTGPKSVLNVHGEEWKTLRKRFNTGFAHQHLITFLPVILEKAAMFIGHVEKFAQTGQDFSFGFHSANLTFDIICSVVMNSDFGAQSLDSPSEFIRVYHDLFETYAEEQMDLPWFFTPLTEWKRIRLSKRIRNILRGVVRNEFDRRQIETVKSRSVLSLSLQDVNTLTPEVIGEACDQLNTFLFAGHDTTSVLLSWLFYELSRTPRALKAVRDELDDVFGADPSPSAVREKLLSNGGKDLVSRMTYTNAAIKEALRLWPPAATARVTGTEGSGITIKTPAGDVYPLDGVYVYNCQILIQRDPEVFGETANEFVPERWLGEAGEKIPPSAFRAFERGPRNCIGQELATIEARVVVALLARRYDFVKVGTGELSLDEAGMPILNANGQYKVVSEMYSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF75</accession>
    <name>A0AAE0KF75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">B0H63DRAFT_265929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF75"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="41"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="125"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3375077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="46904" checksum="C8ACCA5DF3B6C47C" modified="2024-05-29" version="1">MAQDVCPARSEPALSFTQGLILGQLSVVLLLVAFIKFFIFGEAPSPDVTAALRATERRSQTLAHKKSLLSLRRTSNAATLSARPSLQQPPPTLNKKKSSILRPSPPTLTIGSILDKTYYKVDSHQPESLDWFNVLVAQTIAQFRSDAQHDDAILTSLTKALNGTSRPDFIDEIRVTELTLGEDFPIFSNCRVIPVDEDGLSFDPGKAFNANTATREGARLQARMDVDLSDMITLAVETKMLLNFPKRLSAVLPVALAVSVVRFSGTLSISFVPSNPSENTPTKMTFTFLDDYRLDFSIRSLLGSRSRLQDVPKIAQLVESRLHRWFDERCVEPRFQEIALPSMWPRKRNTRGGDDAIADVERSMSMSKGKGVDIAKELREEARKEVAAEADRVQDSLRFRRRPRAEDAFAMPGSMPGVGLDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJR3</accession>
    <name>A0AAE0KJR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_398395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJR3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="36"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3377567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="574" mass="65293" checksum="D4D89FC778F51BEC" modified="2024-05-29" version="1">MALPHAADMSFTAHVSSQFATYETDRRMKSKDAIYTTSNGVPMPHPYETQRLSEKGPLLLQDFHLIDLLSHFDRERIPERVVHAKGSGAHGLFECTNPIPELCQADIFSTKGKKCPVTVRFSTVGGEAGSHDLARDPRGFAVKFRTEEGNWDLVANNTPVFFLRDPAKFPHFIHTQKRDPTTHLGSGDDSTMFWDYLCNNPESIHQVMILFGDRGIPDGFRFMHGYSGHTLKLVNKNDEWVYCQIHMKSMQGTAFITQEESVKLSPDYSHKDLFEAIEREDFPRWSVEIQTMTPQQGEDAWKQHRINVFDLTHVWPQSMYPRRKVGEFCLNENAVNYFAEIEQAAFNPAHMPPGIEPTPDPVLQSRLFSYPDTHRHRIGPNYQQLPVNAPRTAYWPANFQRDGGMAFFNQGTRSNYLSSIDPIHFKERSHDSRKIHGPFVGDAIAYLSEIRPEDFNGPRALWQKVWDEPARQRFIGNVAGKMAVCREKEFIRRQIAIFREVDPDIAVRLEKATGIQGYDGIAEMRFNGTHNGMTRDPKLRFANGMDASRSSLPLHNGAPVKTPMKGTDGVNGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJV5</accession>
    <name>A0AAE0KJV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_435720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJV5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3377542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="50523" checksum="2F3A6630383137FF" modified="2024-05-29" version="1">MPPSVPRRRSRRLVRDAGKFPHPNAPSVDQGPQSGIVTIPSKNSNDVALLRIEDLMETILDAIMEGNELFIPYRSVRSAQAEGDSQKTSFVRFPGRNIQEVKKFEALFRILELSHEALLSGNIITKRNIYYQNIELFKSQSTVDDMIDNLAFTLGVGRGDLNIAATAKGLIAGLVDLIMKGGSIIKCDHSHDGGTLLPSIDSIDKVDFRDAKWLLVIEKEATFRTLAESQYANNSKAGHGIIVTAKGFPDLATRRFLSILHSVRPTLTVFALVDFDPHGIAILRTYKTGSQRFEHEENVTVPDLKWLGIRSRDILSCGSGISSQDSQSSDFQHLGSQRSQDISSQESLTFSYDGSQEERHNKRRRVRKTRDPSETVASLTQADRKKAVSIMKEICAAEGLGGGVAAEMEQKSELQRMMMLNIKAEIQAVDNYGDITDWLNERLCNQQQWNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKT4</accession>
    <name>A0AAE0KKT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_223433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKT4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3377735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="402" mass="45957" checksum="DD2AE7EFEF8B84AB" modified="2024-05-29" version="1">MLLPKGGVSWKAARSSLPPTRAIWTVVTRPRFLLFAAVAGIILLLWRGVRSQANDLQSFYCWGPKKSPMEMTLNEQVSWNKHLNTPVIFNHHAPIEVNSSTIQHVDLNPIKSTPKALVNQERVLILTPLKDAAPYLNKYFELIAELTYPHDLIDLAFLVGDTTDETLAVLATELERIQKRPDKFRSAMIVEKDFNFKLSQDVKDRHSFEAQGPRRKAMGKARNYLLSTALKPDHSWVYWRDVDIVDSKPKIIEDLLSHDRDIIVPNIWFHRYKDGVDIEGRFDYNSWVESDQGRKLASKLPKDVVLAEGYKQYKTGRTYMARMGDWREDNHMEIELDGIGGVNILVKADVHRSGINFPCYAFENQAETEGFAKMAKRAGYGVYGLPNYVVWHIDTEEKGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKW3</accession>
    <name>A0AAE0KKW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_237098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="435" mass="48641" checksum="0D5510B14559AF7F" modified="2024-05-29" version="1">MNFPAPPSFHDPLLYPPTPIATSSPNSFSTTASSSAPTTLPRQQQQPHLPSREQQQHQQQQPTGPSPNPQQQLQLQYHIQQQQQQQQQLQQAPQQQQQQVLVMNGMNGGNLPAGMVGLPTPAGHQAELNYIYSMVEDLSRQLAQNQRQLEDVVVGVGRVRGRARAQSLGNEELINAAADDVRAQEPNMDALISLLSEALEKAKFSRDANAALLSQYATVVSTMLKQFHDYKARHVADVAAWHRSYRAQLAEARAENSRLREQIWEMKAHAGHANETVRKFRARYDEDSERWERRVDARAARQELRFWKRMAMPHLPDDDPYWSDDDDLIDPQEKLRLEDIKRTMAEQQLAAAAAAAAELADQGIDGESPMDYQLQHQQQYQQQHPPPPLQPAPPVPQAFSGGVPMQREDSGNMIMPIPPPRPSSAASSTGSTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLR9</accession>
    <name>A0AAE0KLR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_247768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000006">
        <property type="entry name" value="Heat shock factor binding 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="75" mass="8110" checksum="591D26CE0A539A0E" modified="2024-05-29" version="1">MESNPDSSAASQATSPSDDARAELTAQLEELLNTLSNKFAGVSSEIFAKMDEMSRRLDNLEAQLIAHKDKPSGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLY7</accession>
    <name>A0AAE0KLY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_252352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="51661" checksum="AA8966C71F504135" modified="2024-05-29" version="1">MNSLLFERSLGNLGPNVFATLQTTTLLRSFAPAPRFCFDGGYRSPGPSEGSSTPLVGDAVEQPFLLWAHQAGVSSLALERFDGRILVSGGSDATIKLWDLEQCSNSSSPHLYRPIASIPRAGDQQASASGHRFGITHLSFYPFDSAAFLSSSYDHTLKLWSTQQARVSGSFNLGAKVYTHAVSPIASHLLVACGTQHPAVRLVDLRSSSAVQSLVSPGQAGGSAGATLATAWSPVHEHVLATGAVDGAVRIWDVRQSSGLVALLDQEDSFGIQGGAELGDRVIRFSARAHAGPVNGLTWTDDGAFIVSAGHDRRIRVWDAATGANTLASFGPTIRNSQLGSLTMFTSPLGLTASQQELLFFPNETEILVMDLHEGSIVTRLRGMGPSVSAIRAQRGGERAVKNQLTSIVWRGAGGGGSSSGAVMGGTNAPGGIYSGHLDGQIRAWLPQLGGLDEEDKDISQEVTVAHAKKRKALDDTFRSLMGKQITFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1A6</accession>
    <name>A0AAE0N1A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1A6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="237" mass="26545" checksum="8B5E97F5305EF849" modified="2024-05-29" version="1">MDENGVQEGETQQGRVVGTSLTRRSPKKASGHSAWATILYTNALQPLDVAAFSALKSFYHQLAMDWVSYDIMALVAQQHFLSFTTTGLVPPERNKVLEKEGLFIEVDEEKGDEEGPYTPPPTRPSRQDYIVATPNTSRYIKLAMRRHHQNLTQADHARVQLLSKAGKALDQKNVTIATLQAQNHRHHLKLKARRATKRRTVKFDANETFASIQEIRSSQMEARGVVEAEEGNIVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1C4</accession>
    <name>A0AAE0N1C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_405333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3366538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14429" checksum="1B9625F7795D1E34" modified="2024-05-29" version="1" fragment="single">AGLSSLEATFLASGFFAIVIVAVTIPATLCADRWGQRLSTILGGIGMAATMFVMGALYAAEIQRQRTRASATSIAHGSNWLMNFLVALVTPTLLDKSSNGAYLLFVGCTFLTAVVCWLFMPEARGRSLDEIDEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4B9</accession>
    <name>A0AAE0N4B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_405671</name>
        <name evidence="3" type="ORF">B0H63DRAFT_497322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000026">
        <property type="protein sequence ID" value="KAK3365400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4B9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="85" mass="9618" checksum="99115C6D7E39B70C" modified="2024-05-29" version="1">MCYQLVELYSACRCLYYQHAVDRCAAYGQPGHGIQRRTILVGYACSDHSSHRSSGYDYSSYGGQYSDSGYQSSSRSHKSSHGRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5U1</accession>
    <name>A0AAE0N5U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_526779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5U1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="302" mass="33925" checksum="B5A08DC60AD6466F" modified="2024-05-29" version="1">MPSIQKEFSRTFALVTGVLEHKADARDVSMASLTRRAFAIFDESRHAVKVVLVVRTDEARNEALVVKWTEVEELEFDGNSCSFVTRYGRVCQSAIIAGPDKLHGCFSKEPSLVHPDGFSVRGDNIRLSIGEMFARNISVMKKEAQSRENPGKAESPPRKADQGRQSGGRARRSSRHGRGPRVELWGSSLRVGTLVRYHECLGVRAISSERWDSLRYLWFFSMKTLLDLFMDVVSEGEGEGKPWAASGRTIQEMCGERRIPDPCRELRLAFQGVDVSHGSEERAKWPVFPDSQVHSLADRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5Y6</accession>
    <name>A0AAE0N5Y6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5Y6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="780" mass="84484" checksum="C90BA87281EEDF5F" modified="2024-05-29" version="1">MVTLQNEEYFRWAREQSSLLDDDHASDGSYSPIRPTSSSPGKRPQSGSPRKKVVLSSENVRSLKSLMNFQQRQSLSIRSKSSRHKTGRKSQSTKTMQKLMPSPFEPASLSTVTVTSPPMKDTAQEPNEDAYPFDLTKNSWEFDIESKEEWHQSNLARNDLGHSGSDDIGSEARPLLKSGDRLYSDWVGEWGHFYGVIRKIPGVWLSSLMGWADISAQAIKHALSMIMVMEPFVSRIPIDPATAPPKAQPRRPSRKRKASPILEEIKKKVKKSDGTIYDATNLAVRANGTLEVRLPSRKSYTPSPPTNSTQQPTDKKLAGFQLWSYLKFMLYNTFETKSPHVLELLPLKRLRDLPETWQTRLASGLPSTKTLCALLVYLTGIKAASACGDCVIIQAYSVRGGATLEEANTAASAFSECITLPATASAALREYFGANTCCNRFYRSASHQSVTDIRGLFLASSCSSSSATSSEYPSPSTTLWNAESSSLLSEETVTGTAHTTIRLTKTMMLEHSTLNLRAGSSSTSSEESESSISNSNASSDSISARPVMQNEPTDAAKARSAQKKAAEAKMITAARSQSSSTSLTSATSRSSNPADASDTYITTPDTPTRPTPSKRKKSPATTAVGANKRKASGSAATAAAAAAKATSSPAVYFSSSAVPMMAEWERAPGRISVRTEDGASENIAFSSAYLSKGAVTVTDGVEFRKVELQPGGVEVFRPNDSTRVYSVLQGIVEIDLRGMNFPMGPGGLWVFKTSEACTLTNPFYQGALVHVVSMDCGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6U9</accession>
    <name>A0AAE0N6U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_484327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6U9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="264" mass="29200" checksum="A32ECD387E828FDC" modified="2024-05-29" version="1">MAAQEGEWNQVSRKRGRLRHIPTTAQKPTTGGTESYSLLGLRPNPSPEFTVSDIQRHHETACQDWQASQCWQVLQEILLAAAAAETRPTITKAICLGPGPFDPSNGSFAARRTAHIQTAAFRSIVKTIAGSQSCQEIKCIIQEPGFTQTDKDFCAELGLEVAETPGAFPMVDASTLVFGIHMELRTYHQALANLPAIFIGAGLDEWKKVIDFEPGIQDLLRSISEMDATYNKYSFPDLNYMFSSTTVYWRKSEEVEVPKSSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N996</accession>
    <name>A0AAE0N996_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_452780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N996"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="472" mass="54414" checksum="E676395328ED642F" modified="2024-05-29" version="1">MPMEEIHLSTPHPYPLPDMFDAMLEPHREGPDWEWIREKEIMRRMRRYTMRDEARYCTTGLQLMEMAGVRLNDEQKKTRPFANSVFDFSPARMWYEVELLARTRYNALIRDHDRDRLEKGPMLPCLPCLVKKMPCSLELVKDQRALRCRRCERNGEPWCVMYATTAFGMQDAWRCSPYVIIPRRPKTTWVEVEDLLLGWCDAEFVGGCRREVRGSIWAFVREPGLSCEELEALTRDILRDGEERSFGAVTSVPICSFDNSDVFALPGFHRNDAPEYKADPDYQDKTWQSFFEWRRQKIELAKVEVLGAAVDVDDNRETANLNEKEESSSQVSPNNNQPEQAANPNSENQASFLEKVVELEKYIDRVTAMASYEYEHTEKVISEALEKLRRPTPSYLEDMGEENSNSSEIGNPNQKEEAGVLAILNKHGFQAEAVPDVLRVGEKFVNHRQSQAKGSATSKDALPQIPEGDETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9F0</accession>
    <name>A0AAE0N9F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_400102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3374983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="31725" checksum="CF4B976383024071" modified="2024-05-29" version="1">MTFSTKATIASFGGKLVKLSHASSSTGTDMAVNVYLPPQALAGAKVPVLIYLSGLTCSPENCSEKGFFQHAASARGLAIVYADTSPRGLSIPGANDHWDFGEAASFYVNATRPPFADNYRMETYITSELPSSLVADAEYGKYLDGSRVSITGHSMGGHGALSLYLKHPELYKSVSAFAPIANPTQCPWGVKAFSGYLGDEDKEAWKQHDATELIKGWKDKTESLKMLVDVGTGDKFYIEKQLLPENLEKAVKDAGLTGFELRYQPDYDHSYYFMASFSDDHVNHAAKYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9M6</accession>
    <name>A0AAE0N9M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_252923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9M6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="300" mass="33114" checksum="4C24C44CC4F0B3C2" modified="2024-05-29" version="1">MLRKMAPLALTTRIKLPSGFEIPQLGFGLWQTPAKDAENIVNEAFAVGYTHIDSAAAYKNEAGCGKAIRTSSALPREQIFYTSKVPPGPKGLSYEVAKKQVDKSLAEAGLEYIDLMLLHAPYGGSAGRKGAWKALVEAVEAGKVRSIGVSNYGVHHLDELEKHIKELEEERGGPGKGGVLSVGQWEIHPWCARNDIAQWCAKRGVAVEAYSPLVRGERWGEPTLKKLAEKHGKSEAQILIRWSLQKGYIPLPKSVTPKRIRENVDVYDFKLSPEEVAELETDEYAPVCWDPNTSPLDNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBG6</accession>
    <name>A0AAE0NBG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_229975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBG6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="333" mass="37525" checksum="960AD77B2607FEB8" modified="2024-05-29" version="1">MSYNNNPYQQAPAAEQGYGSRQPHEMQPVYGQPYNSQPYSNEPYNSPSQQDYNTPNPQQPQSPNVLSTGDFLQRVSAIREDIQSLNASVEEIASLHQRALTSSDGQARSQLDALVAQTQIKNTSIQGQIKTLKSDAERTTDGSFGMKKRQFESLNNEYKEQIQRFLREEQEYRERYREQIARQYRIVNPAASEDEVRQAADADWGNEGVFQTALKSNRSGHASEVLRNVQARHTELLGIERSIRELLDLLNYLNQQILEQGQVIEAVAQKADETETHLDNANVQITKGVEHARRRRRLKWWCALVVFLIIVAIAVGVGVGVVVSKNAAKAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBR9</accession>
    <name>A0AAE0NBR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_221031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041956918" evidence="3">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="196" mass="19892" checksum="89DD575C54496EEA" modified="2024-05-29" version="1">MRVSLLYSFLTVLVAVTAQGTLEFDDYASLLKRQAPGTPQYDCHAACGRVVAARKETGYCTNTSWTDAYAACLKCALQYSIWSIYGPGVTSVSQACSLTPTPSPSGAVAASTTSVSSLTTEPSFISTTVALTSVPTSSPSIRPAAGLNTTTTTSTSAAGSAATTSPTPTAGARRLASGYLLGVGTLAAIFAGLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC02</accession>
    <name>A0AAE0NC02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_477902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC02"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="49332" checksum="0D964800CF4E08AC" modified="2024-05-29" version="1">MAPAEAVDDVDVNMEDLDDADQAQRIINEEYKTWKKNSPFLYDMILSTALEWPTLTTQWFPDVKDVKDKNYRIHRLLIGTHTSEGKPNYLQIAEVEIPKMIEPNPHDYDEERGEIGGHGSKAAAGEPQVIKFNITQKIDHPGEVNKARYQPQNPDIIATLSVDGKVLIFDRTKHSMTPTGTPSPQIELIGHKEEGFGLDWNPHVAGCLASGSEDKTVLLWDLNTIQGNGKTLKPARKYTHHTNIVNDVQYHPTVKHWIGSVSDDLTLQLIDIRRPQTDSAAVVGRDGHSDAINALAFNPRSEFLIATASADKTIGVWDIRNLRQKIHTLEGHSDAVTSLSWHPTEPSILGSGGYDRRILFWDLSRIGEEQMPDDLEDGPPELLFMHGGHTNHLADFSWNMNDPWLVCSAAEDNLLQIWRVADSIVNQDDVEMPMGELDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC05</accession>
    <name>A0AAE0NC05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_478293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC05"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="801" mass="86034" checksum="B7876250B0E86E10" modified="2024-05-29" version="1">MDFLKSAVASAIAKGPPFPYTFGDKVEGLDPSIWTLYNGTKRDDGSNCSIFSFDITANRSAFPLARNALKKLRTMRHPGVVKVLDAVESDTYIYIATERLVPLRWHVKRKSLSPETIKWGLYSIARTIKFINDDATSIHGSLKVASVFTSESGEWKLGGFEVLSNVKDDEAVVYTYGSLVPDSGRYTPPELARSGWDAIKRSPHSAVDSYDFGLLIFEVFNGSFSGPDQAGQTKNIPPSMQSSYKRLTNPNPKSRLSVGHFLEQGQRGGSFFDNPLIKLTDGVENLGVKSESEREEFLDDLGQLSDDFPEDFFKMKVLPELLKSVEFGGGGPKAFAVIMKISTKLSNDDFEAKVTPVIVRLFGNPDRAIRVCLLDNLPLMIDRLSQKVVNDKIFPQIVSGFTDVAPVVREQTLKSVLTLITKLSDRIINGELLRYLAKTANDEQPGIRTNTTICLGKIAKNLGASSRAKVLLAAFGRSLRDPFVHARNASLMALAVTGDYFSDEDCAARVLPAICPLLIDKEKLIRDQAIKTIEIYMQKVKKSAAAMPDSALPPETSITGGPRMSMPQPTESSSASAGWAGWAISSFTNKLSAAAGEIQSSSSTTNGQVAALNSKRPTPASTTSQSASALHRQALKSPPPTTASAPLSRTSSSGGFGGESFFQDPDSIDDDGDAWGDMDDGTGDDFFDAVDESTASPQPTSMSSSTTLPAKKTSSSATASAVPFDDGSEPDFAGWLAAQAQKKSGGLAGKGLPKGLAKPAAAPAKKPASSTVSKLKPLPAKKKIDLKPKLAEDDEGWGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCI2</accession>
    <name>A0AAE0NCI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_245861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="123" mass="13215" checksum="028ED38009A323A3" modified="2024-05-29" version="1">MCRGILVTWIVLESSSWSSSRPLRLGQGGDGRSNRPSILTSKMAGANRDEASCFVLMFWTRDGGRMPSGRMILDPLDAALAFMPKGSRNTNRPLKGIGQFALRACGGSPECASQQSPPTSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCM1</accession>
    <name>A0AAE0NCM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial PGP phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_248960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="24067" checksum="1B935B8BACF2656B" modified="2024-05-29" version="1">MNMNLNLSASLNIFKLLTKPSLCLPHATVATFSDLPVPMDKAFAREKGHPAATSIKAIVLDKDDCFAYPEASEIYDAYKTRFEALRAAYPGRRLLIVSNTAGARSYDVDGKLALEVEKTTGVAVLSHQVKKPGCGDEIMRYFQKHPETGVTSPRDIAVVGDRLATDMMLANMMGSWGIWVKDGVVPLQQKSIFSRIERKLGPYLMSRGFAAPQPASPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG50</accession>
    <name>A0AAE0NG50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_560712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG50"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="145" mass="15733" checksum="04239C5BD3AABACB" modified="2024-05-29" version="1">MESAFEMLKVRISKPPTIQPAAPHIWKKVEQKAGEESLLGNTVSPLPLHMRIGLHGATYLTQMKQPIDTIATLPTEAFTHFINSILDPLPPSLSSTLVNAHGFYDDIPLLAAITRHLYQVALSLLRYGAKVDELAHSTGALAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGW3</accession>
    <name>A0AAE0NGW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_545815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042058572" evidence="2">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="275" mass="29470" checksum="0F942E7F82CE1446" modified="2024-05-29" version="1">MVPYSLRWCKARILLRSLSLLLALTVTAISVVNAAGGITKESRLEFNRGWKATLPAAATLILYDMIELVAFRVRRHVRRGLHPGASVGADLFAWMVACTLGIAFNTTLSDGQLAYDILGAEYNVYNLGYPGWLPLEYITASPIDIAASVLLAVLLILHFVLFVRACVETKQRNGAKSLSRVLAAAFDYTCQGEDRYMYTPSSGAAPFSVTSNTSELSMKLGDGDAASSTYASGGGGDCASEGVVIQPPASVGMLARPLSRSNAGSVRSVRDIKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHX7</accession>
    <name>A0AAE0NHX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_546427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHX7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="499" mass="55552" checksum="93CC5F82CF7AF9C6" modified="2024-05-29" version="1">MEEKKVIPSSTEEATSASESINIPDQEAQGWDEKATKRLLSKLDWHILPIMSIIYLLCFLDRTNIGNARLDNLETNLGLHDLQYNDCLAILFPFYIAAEIPSNMMMKRVRPSIWLTFIMVCWSAVMIGQGFVKDYSGLMACRVLLGVFEGGLFPGVNYYITQWYCKHETGFRMALFFSAATLAGAFGGILARGIAEMSGVGNLPAWAWIFILEGLLSILVSFSAYWLIHDYPATAKFLTKDERTEVQRRLLEDHGHLLDDFNLKYVWQAITDWKIYIFMLTCMAAFCPIYSFSLFLPTIIRGMGYTANNAQLMSVPPYVCACFFTIVASWLADKWRTRGVFLLGFQVVAIAGFAMLAGTANASVQYAGTVLAAIGIFPQVPLGIAWNSSNVGGSSLKRGTAIAMQVMGGNTGGIIASYVYLTRDGPRYIKGHSILIGFVGMAFFLTLLMTVWCRRENTRRDALADGGSTGAGVPQSLTDEQKLLERDLADRVLWFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI08</accession>
    <name>A0AAE0NI08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinoxylan hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_561476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI08"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042280527" evidence="5">
        <location>
            <begin position="23"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="359"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="571" mass="61687" checksum="407B05D5C781390D" modified="2024-05-29" version="1">MHFQSFQHVFFTIFPLVGLVSATPSPLPATAAAAAAPSTFTNPVLWEDYPDLDVFRVGDVFYYSSSTFAYSPGAPVLKSYDLINWEPVTHSVLELNFGARYNLNTSSSAYVKGIWASSLRYRASNDKFYWIGCIESSKTYIWTASGTRAGQNNGEVAPDGWNWTASSAGPINACYYDCGILIDESADGKDDTMYVVYGNTKLSVAQLSADGLRQVKTTQVFAAPSGMTIEGARMYKIKGTYYIFVTRPADAEYVLKASNPLGPYEMRPFVVRVPGPLASAGFSHQGGIVSTPGDKAWYYVAFMDAYPGGRIPVVAPLVWSAEGWPSLVTDSGTKSWGASYPIAVQTNKTVSVPSSLGLDDFKGGKLGQAWEWNHNPDNAKWQLVGASGGLVLRTATVTGDLFAAMNTLTRRILGPKSSGTFRLDVSGMREGDRAGAVLFRDRAAYIGVWKDKTGIKVVMVTGLNLAEGTWTTSGTGTVAATGPILADVAATKNIWLRIEADITPAFGSSTERKAVFSYSLDGKTFTTLGSPFSLSNSWRYFTGYRFGVFNHATSALGGEVTVKSFEMQRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI68</accession>
    <name>A0AAE0NI68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_216863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI68"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30992" checksum="2229406E575E0B9D" modified="2024-05-29" version="1">MAEDQRQEPVSSAAARVRENQRRSRARHREFVEGLQIRIKEYERRGVEATLEMQRTARAVALENSRLRALLVSRGVSPNEIENFLSSFDDQLAHIMGDAPTTTTTVALPAQARCGPKPRRLSRNGNGSVDIRATRSRRSIDAAATMCHGMTDADHTEDDRFQSDDTIPMSDEPALFSDRNQEQTSSSGPFSSYSSSDTKDGLMTFTPQRHSRWQTERSTSPSLSPTASGSPMEMSCTIAASIIVSMQRGQTETRAREALGCKGTRDCLVKNTAVFQFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP01</accession>
    <name>A0AAE0NP01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_472237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP01"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="103" mass="11067" checksum="289D19589154EAD5" modified="2024-05-29" version="1">MHSSHSEVQCDGSAATPKDPISTYCSFFLLSFLPILYKGDRGSISITSCSHMLIVFLSYVSSLVTRKAGALNKGLQISSWKFGVLHLKVFGGGLNMGGSLVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP17</accession>
    <name>A0AAE0NP17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_559774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000007">
        <property type="entry name" value="Regulatory protein SUAPRGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="298" mass="32895" checksum="F460A3E8C59860B8" modified="2024-05-29" version="1">MMMSLRAVARSAPRATLARAAMVGRCQAVSRTNSLLKASATLRPQQQQLSTFSTSVFRRNAPSETDEELSTKLTSEIEFEHDVKEHEPLPASVKDFLENGPFEIVDIPGKEEVILTRTHNNEKITVSFSIADLHNYENDPYSEEDPALADEEMDGDVNGQQGSRGASDMEGEDDMGAGADEAAVPCRLNIVVEKPNKGALTIEAIAQDGTIVVENMFYYKDAKLAHGESADATHAAQDLYPGPPFGSLDEDLQVLMERYLEDRGITQALAVFVPDYMDMKEQREYLAWLSNVKSFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP49</accession>
    <name>A0AAE0NP49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_177087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP49"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="289"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3385025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="760" mass="83054" checksum="409F1DF61742DE7E" modified="2024-05-29" version="1">MATNKRRRLDTPGQPILSAFAARQGPWGAFPGREDIEKADLETSAQQREAAEATSAKTALDRKGRGKGNGNSKRQATYSQVPQTLDARPIQTQRRETGTSVPSTPVLTPILVPTWPETQKWASIHYSSFKPTKQNCQRRKDGCVLLTVPEGERLVILGSYGIRILEGEATIAGAFLMASSSVHMVHAPHCHAIPVLRTTKDSSIMLHPHPTAQGLRQLARLNPVFGKLWNEAPHKAGKPIPTYQIIFTSDDGPKRAFLQDLISPAEWNKKLAGLMAAKQKALPIVFLCGPKSSGKSTFGRLLANRLVTGHGGESRKRPLSTVVILDLDPGQPEYTPPGLISLNILSTPNISPPFCHPYPVTPPTTRSGQLRAHAIASVSPSVDPAHFVECALDLFSHYQRSAETNKHPLVINTPGWVQGTGLDILVELVRHICPTEVIYMSQDGPEETVEGLKSVCRSSGENIPFHTLPSQSSEGPSSRTSLHLRTMQTMSYFHLNNSKPHPSEQDQAPLPAWNPAPLTELRPWRVRYKGAERGLVGVLCYDHQPAPELLLDAINGLVLALVHVEHKAAYRDLINTATTEYTSTESSTERVQGVVPAIVSAAAGIPLITNPHGRTLDPRYSRALSLVLVRGIDAYRGELQLLTPLPSTELLRTSGKNLVLVAGKFDTPSWAYSEDLHARAFGSSAAVAAPAPGQGVDGEDDESDTSSEEEDDEENEQQQDNKARSLGSHTEFPWVEMLHGSQKRSVGSRVWRVRRDLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPH9</accession>
    <name>A0AAE0NPH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_510158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPH9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="242"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="856" mass="97092" checksum="065CA226DCF9A445" modified="2024-05-29" version="1">MELQDDLLCAACKQLGLASIFDPRRFDDLPGLDTPEGASAKWTRYIQHVGHWSFPESSDNPVAASCPFCVFVRDAVTRGLPAWSKKSRELLVFPSYLLYDFVNFASASSASQASIKVPTTTYLLIVNHQYVEAFDMFNNAESWVDWLRRVCHTPFVAASLSCCVMPHLDGESSGTPPLSASPKTLRDDRPDYQAIRQWLDICVARHGALCSPPSGPPVPRLKLIDCRTRRIINAEPGKKYDYVALSYVWGKKPPDSYDYPQLPESLPLVILDAMTVVLRLGLQYIWIDRYCIWQEDQVHKMSQVNKMDQVYGDAYLAIVACAGDDPSHGLPGHHTMITHRSFQDQREAVAKSVWKSRAWTYQEECLAPRKLYFTDYETSFECHGMMCFEHLALPLAYSSNVGLETQPFWNNKHIHNKPEIIWALVGEYSERQLTYQSDRINAIFGMFNAWSRLHPECSHYWGVPIVAAPSCWKMVDDSEFAIDMNKYIWQGGVSTLTRALLAGLYMWSEDAETQAGERPRHFPSWSWAGQGSKVKVGTLYHRGPTALARRTFEYDAPVWAERPDGTTEAWDKFCQYSATGRLQLPPATQWTPYLHIEGWVFKVGPFCRLTIKDEPATSNIFHVPATVAASSGDQPTPPHYREFKADYCQHPGPDALLTTQYEAITFEPPASARFALVLRGCIDQDSGGAFFERIGVLELAVWEIEGDRKRGEWKIMSVDDDQVGSHLANHVKNVSEVQSFHQCLHTIVITFFGQLRECRRGRRISGPRCIVRVVIDQGAVNVQREQLGCIELRLLYRLPLCFCMLQRAEKVECHFLLSGEGCFGVLASVAEGASLASDEIERFNCNVRYFIQHWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPL8</accession>
    <name>A0AAE0NPL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_472807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPL8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="36856" checksum="8F3436D23458596F" modified="2024-05-29" version="1">MQIPHPPSSEPTAVAQVVNTQIRTSRTVETATRKEITSITTTTHHQDHHHSTNTDNGRKITLPLSPTSACSGSIENLLEHPHTISKPTTNPSSNVTVSSSQPTPPSSPPTPEVSQFKRLSPAKRMNSDSEEISPRTSKRRGPSFAITQSSYNSDENMSFNAEDEDEDDSDSNCGFEEEALGGFACPLQAFDPQKYSHCYHEQQHQGGFRNLKEVRQHIQNAHRRKPFCPICRATFPTAWESDQHIRSRTCSLRTAPEIEGVHEDRMDELARWRFTREESHDKQWRAIADIILPSNVGKEARQKLQPRISSTVVQEADSDWVDLGKADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPQ8</accession>
    <name>A0AAE0NPQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_560043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="188" mass="22393" checksum="5F9BB9EC97E630D3" modified="2024-05-29" version="1">MAKQREEELRDTQGFWGLMHARGFRMMQFHGTEPSALEILDHLVRTQQERGNLVLTIQRELVDEKKELDSTSTGKELRREIDKATEQYQQKLEDLKEEHDDALNRRDAEMAKILEGQRQDFEEKLNEANKAQDELRINMERLNRKRTPSMRSCSPRSQNWWKQVEGLRVDKDKAQQQASQMEEVYNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQF2</accession>
    <name>A0AAE0NQF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_186345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQF2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="310" mass="34983" checksum="84CA1B9A61DCFB96" modified="2024-05-29" version="1">MATYTPDQLARYFEHIGWDASSWPPTGTLTAAFLQELIHRQLARVPFESVSLHYSPTHLLSLDPEDLFHKIVGRNMGGYCMENNTFFGTILRSLGFNVTNTGGRVSHATAGRPGPGYMGWNHMVNLVTIDNDKFLVDVGFGYNGPSQPLALESGVIVPGIGTALRFKLTYTALPQHTDKSQRMWVYSYREGSKAAWTDAYAFTEMEFFPDDFAVMNVATMTLRRSFFLQTLFCVKMTLDAETGEPSGWLLLNHDQVKRKDRDGATVLVAELKTEEERVAALEKWFDIQLTEKEKTGIRDLSTELRGWSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQF5</accession>
    <name>A0AAE0NQF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_449778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQF5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="149" mass="16619" checksum="E5417B8681563489" modified="2024-05-29" version="1">MVMKLRRLCNHGTMALPDTDRPVEMELSDNIAVLPHAHVEVLLISIQTGSVGLNLTAAEHVHVIEPQWNHSVEDQAAARALRMGQTKTVRVFRYVMKDTVEENILTRQKRKRKTAKFTMDGGSWDGISGSLDVSMIAENALTASKLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQH8</accession>
    <name>A0AAE0NQH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_187843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQH8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56422" checksum="B34C64E3F9148DD7" modified="2024-05-29" version="1">MGPANLQKAPSETLLHHLPAHHVLICTQCRYAIQPLAVSRHLKEIHHIYRSHRQGLVDYAKGLHLVDPADAVLPLPHEAPIPLLPTENGLACARDDCTHLCVTVKRMKSHWASCHKDLVGNWSPQWRPVALQTFFRGNQLKYFIVTPQDTSPEFPTDFLSLKLEFPPDWTPDHVALFKHFTQTTYLGMSASPMSRQLWQAAIPRLAFSHTFLKDGILACSALHLAHLHPSHKQRYRIIAARHQALALPKFRELVAAPTDETCNAILAFSQLLIVHSFAAGEEDESLLLVKEDPNGGALESDGLPDWLRLIRGSCTILGHVWANMKSGLLKPLVEESYGVPVNRPPPSDNTVPENPTAVVAQAQLKQLVNLPILNEPNHEKRTAYFSALMLLSRAFRCASVAKESGAFSMWTVVQVWPSRVSLEYLELLLRAREPAALVLLAHYCVLLGPLASAWYMDGFQKRLLDRIYWQLDADWRRWLDWPYAEAGLMPPYRAGFVFPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQX5</accession>
    <name>A0AAE0NQX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_510519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQX5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="260" mass="30725" checksum="208DDA7B15DA12A5" modified="2024-05-29" version="1">MSSERILLVKPPAKVVRGVLQRQEDFRFEHERSNPSRRESRTWAAENILDPETNIFDTRDFVLSMHRRAGGSPDVLIDEAFGLYVQFINAHPIFLLEPNEPEVVTFFPCWGDDLHQSNRRVAHYRMRQFLHAMRHGNVDYAKDWINFSHDDVVAHRFDYYKWAREHRLDFDELVRYQHSSPDDWEPVFGPEDTSLAIRNPNNGELIPGYNPYMNWNTSQNVLALASETDTDEDQELREVDRRQNDDPFALNNLSRHVMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRT7</accession>
    <name>A0AAE0NRT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_493317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRT7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="197" mass="22244" checksum="6B709FEAD44E78D4" modified="2024-05-29" version="1">MAEAIALIGSVIAVVQLADRVAKACKFFIDTAQDYPKDLRLIYVEIGSLKLIYEGLKMLDPNDPSESATLTALQEPVRRSWAVLARSLNADALKKLLGEIMQYKSTISLALQRQLLGLYESGTRDWVISTPEWDDWINFRQRAIWLHGIPGAGKTVLAPYVFDRICGICMKNDKETADESIPFLRWLVGRLPFYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRW8</accession>
    <name>A0AAE0NRW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_447536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRW8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="882"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122922" checksum="B96E810CA0B30170" modified="2024-05-29" version="1">MPLTKTLILRRQPSGVSRSGCRSWRRFIFYRGVTVPSTHLLFAGIETHGVDPPAFVDIAKSLQSNPLVRNGPTYDAARLRPERLQELFLHLLREELRLGSDIASRPDAALSPASRKRRLQPPPLLTLKDALKHIDKIESIHLKLQDSYLRQTVNEVKQLERQYDQVQAEIEELERVNEAKRIEAEQPAKSPNGVQGLTVQRDQRVENGTGPSPRASPKPVSPIPPPLPPHVAPRQDIRNGPPPPLPRQVSPEKPELATAPSPAPATPTTPAVPAVIQPQVAPVPRQAPEINARKPVARPPEVPKHPSIIPPVLQPPQGVPVFPPSQAPLSPAVSEGLQRPEGVVRLTQSPVPQASLPQLGAQGQGQGQGQLKWEPLYQPNASMSRPGVQPQLHPNMIQASQSFPPRTPQPQQTQQEQLHQHQMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQMQHQQMQQPQHLPPQQQQQIPQQQQQIPQKLQQQIHQQQQIHQQQQIAQQQQRHMQIPQQQLQHQQVHQPQQIQQQQQIQQPRHQPQIQQQPIQTQKQQLPPAQHPPQQPQQVPHTVPHPAPRPLQPQPGKASPQQVLVPPHAPGNAGGQQVPPLQPAIARPAPETPSGAIRNSPLAPNPMAGDSITPHINNHGLEFRTTFSNLNPQPPERLLSHQGFRLLQFMLPKLPRQDSFRDCARKVNEAVESASSNTCAYPSTTAGASTLATAVVTAPVAPPVVQPILEPAVIPPQPTPATKSPTKEASESIDEPESATVKDEVMTPRPPIEPEDILLDDSIVGRRPQGAGKRKREEDSPTPVQPSVEGNLSRDEAIKKERAGRRHEVLWTRSFNKVSGSAMEQIIHHRSANMFAAPIREKDAPGYHKVILQPQDLKSIRAAINHGNRAATQAAAALPHVDPALSNVWVPKTEELSPPKGIVNSSQLDRELAHMFANAIMYNQDPGHGPGPTFLRDHDEVQGEGEDGAGDHVLGYKVDEFGVVNDTRIMFVEVEKLLSELRSAEIQREHARGVLGGPATGTSTRQASVAGGGGGDVSMSEAGFVKEEIADDHHTPTEAESVGNAVKRRRTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSV8</accession>
    <name>A0AAE0NSV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_469130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="539" mass="60356" checksum="8585F1951A5C651D" modified="2024-05-29" version="1">MADINVDVLVIGAGPTGLGAAKRLDHINGPSWLILDANEKAGGLASTDVTPEGFLYDVGGHVIFSHYKYFDDCIDEALPNDDDWYTHQRISYVRYKNLWVPYPFQNNISMLPKEDQVKCIDGLIDAALDFRVANTKPKDFDEWIMRMCGEGVADIFMRPYNFKVWAVPTTKMQCQWLGERVAAPDVKLVTKNVILNKTAGNWGPNATFRFPARDGTGGIWIAVSNTLPEEKKLYGPQAEVTEVDAEKHTVTLKDGRTIGYGKLINTMAVDHLVEKMGNQELITLSKGLYYSSTHVIGVGVRGERPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPQADVKLPTLYLADGSKASSAEAKEGPYWSIMLEVSQSTMKPVDEENLLKDCIQGLINTDMIKPEDEIVSTYHRKFDHGYPTPALEREGVLKELLPKLQNMDIYSRGRFGSWRYEVGNQDHSFMLGVEAADNIVNGAVELTLNYPDFVNSRQNTERRLAQTFNFASTSAPAPAAKEIPTRDRAASKVSVNGGHSRKPSKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU25</accession>
    <name>A0AAE0NU25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_163522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="820"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1485" mass="159635" checksum="78021CD2BDD8A85A" modified="2024-05-29" version="1">MDDEDDEMSRATLEYNSGLDPTFLEFDSRHEYIIDSDGTSPEGYQDFDGSLIEGDIKLPPSPSVTFNLVNQDETSPRNSSRGSLSETSSKRTQSTVSTNATFNSDDLSMDQSIGDSIDAKPDFNFKDFIDDEVYPSDGTIDPHAIDAVPAISSSGMFSFGAPGNNALYSFSDVGSPMSSPVPFSLRGVGPSPPAAHSQSTGENRGLSSNVAYPFRGYEKFPVDLKLYPHPQSMPGFKGGVSREGSPFSTGIMASQDSSPSAASPTVNFDFPHGLPASGPPSQWSKGLGAVSLQQQQQQQQQQQQRQHFSMGNPMAAHMPPKYAMAHAPRYTLSIMPIPAKSRVETQIPVKLVLSSLPPGVKRLHLPTHTISKPKLLQKPPLEPSPDTLELHTTLVCTSAMAKPELKEMALQRARTAAQQLGKVDTPPKQETDDEDIKVQDGGDVKICSGCVQRERKRAARKKVKKIEDENAWTQNETRRVIVFNTQEVKEWQAPNLMEPEPTDGFSVDAPMRIACYCRHHSEKMGFKVIFTIVDHIGNLVAQVMSQSIMITDDHKTHTLPDPSGQLSAACGVVLGQNSAQDTSPSPPAPSFRGSHSSVDLLSLKRAMPPTTGVPPSGGLSPRQQVQQASTVFSIPRNLSRPASPLGMSGPSAKKRKSSGCSKVPSGLTMTRLETGHMPGSQPPSQATAVAVSSAASPFPPTAAPFTPASEPPAYGSGVITPGSTTMSVPHGNNSPLASGAMDQSMFSSGKGTGLSDNMGFDAMYSAPASAHPSRAPSPNGLQTSADAQQSNQLSNNQISQMLAGSMFGAVADRSNASPSPAVIYKVIPCEGPKMGGIEVTVLGSGFYQGIEVFFGTNKATTTTFWGQTSLVCLLPPSHAAGSVPMFLKHQHMPMPQTTQATFKYVDDEEANLLRCALTVLGNKMTGGYEDAVMIARRIMSQQATWGPSSSGVGSDGPYNSMAADPNKFEDHMLKVLELIHLANSPHKAKLDSRLRSSKQTMLHLASSLGLCRFVSSLLQLGANPDLRDRGGYTALHMASLNNHPEIIRCLISHGADSTLRTLSGLTAADVARSKAAIYTLRRVEQLSRSQSSGSLHTRASSANSLKSFRQPSTEVVVKEEDISNDELQPEEESLEYSSLSGSADEGSDEVDDPWLDMRRTSIHHDSMPLEESTPAGLSGAYRQPGAADGAGGLGSPTATVTAIKEQVSAQLQHLQQAALLHFQNFPQQLSQIPYFPQMPNLPLNDYQVIQRLAAMVPAIGGPRPGSPGNQQPSNPATTRDLDGRWWDWSSLMAGAVFAGAGVGANSPPPAYEEIYPHRDGDADTKQASAAQAAAEAEADFKCAALYDNQQQQEQEDETEEAYCADTEEPEASSSRSSLPVLLQIGRKNAITKEQQENLRRAHAKKLKRLSRDRKLFVVWIPLLVVVICLMLYHNFATVRIIVSSLTSAYSSSTQKAFDSLQPQLQQQQRQDAFAVGPGRVMGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYH0</accession>
    <name>A0AAE0NYH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_376459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYH0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="299" mass="34228" checksum="348A00B5B52050DE" modified="2024-05-29" version="1" fragment="single">MWLLDTSKYTLTQTLYPEKYAILSHTWEDGEVTFQDIKDPAVASQKAGWVKIVQTCRLAKGQGFDRVWIDTCCIDKSSSAELSEAINSMFQWYKNADVCYVWLSDLPRAPDGPNSQASQNQLERDLPRCRWFTRGWTLQELIAPRNIKFYDRGWVMRGTKLTLVAQLADITNIAFLLLYNMSELYEYPVARRMSWAAKRQTTRLEDAAYCLLGIFEVNMPMIYGEGERAFQRLQEAIALSSNDMSLFAWSGGPGAAMPFHGIIARSPSQFAQCTKIVNNYEPLHYDSRSFAITNRGVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYN0</accession>
    <name>A0AAE0NYN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="17822" checksum="71561951185E0F76" modified="2024-05-29" version="1">MGCLSALHFWKRRKTEAIDEKNGYETRPLHDSIISENSAISDFEKPLLASGRLGGGGARTAPVPASIRTNVNPAYSAYAGPAPCYGSQPRYRDAQPAESRAWTGSLVSTQVSSTDSTDLLGPEGKEGDVDESNENAVRRREAAAARRKAEQEEQDRLDFFQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYW3</accession>
    <name>A0AAE0NYW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1141" mass="124034" checksum="2A9449F08D551BE5" modified="2024-05-29" version="1">MQVLVFGDSDDDQDQGDEEELDEDEEYDGDNESLRDPNERLIVSFFDISRQRNANANAPKNLREQKGSLVSKNPTTGARRELSHDGDTDMALGTGNGPTRPRLRASSIRRPKILAIHALQGAQESSSLSMDVLRQARTVSLSRKTVPQPPPAVPPLDGPIEGPSDLSPLSLSPWAFGRLPISPDPEDEVDKSKSLELRELGHSSPDWAELTDGIKYIIMFELTRTDNSSMANPMSFTQAAKYLSLTYEETAAMIKLIQLENAKVKSFNDDIAKFNDRLDMDWLDSFLEQDRPARVTEMITDKEIKRGKAFLNFMGLNLIADQLGYYMGMAGNGPLEIPLTHLEADGYKHLIPHFNIACGDRLAEMQKEEWHRQKQRPPVMSTSELLVRLDPPPGTVNPRRIDPTHQPYNPATWGHSVPPEDLAKGLHQSNFEVAVAASIVIDMFDQAAWVRGLATGGFQSGSVNPELQDLNLLRSQPSFVNPHNLALGLSTNQPRSSNTPALGSGPSGTSKGNGKPELRIDTSTAGGDPMGVDLPPNSKQPLPPQTTQAVPSTQSRKGKEVDRSIPQVATPQSTLPVRGIPESSRSLGEAASAQISSREEPGGSVPRCESLQTNEVAPIVDSSLLAALETPTIQQRDPDTQSIVDEYRKKFAGYLQDSDKGRIALRRTSNIRKKKAVNDDYIGSGDRDGSWEPDQPVKKKMVGRKLQTTAVATPGRKKKTALAQTPANNFSSPHDVTSTDVPKTTRPRGRPRRTILASSPDDSEVDAPSSSSLQSPTAGPSRTLPTLNRAAFQEPPSVGGVNTQLTSGQQCLVPPAPGQNPFQGPVSRGIDNLYRTNQQQFVVDPSPNRISAQGPSGFGNENLHQSHDPRYDIGGNQTKFPPITGQAAFQGLSGPRNKVLKETVQEFMARQGLSDMHPSVARMIQERLRPGETVQSAMVRHGLASTPEEPVNKKRKTSENQPQQLNIITAPSLFPEKSKARSNRNRSRDAKKLNSGVVTTEQQQQHVQNSLSTGETPPVHSTPTGGKPPLGGLGATTKTRTPKKSGGKDPALLQLHLTTPPQQTGAKPAIGNYGATTGGSTPRSSGGKDPELLARELARHRSLTPSKNSRSASHYENDGYSEDADGEFGDDENDEVDMLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ39</accession>
    <name>A0AAE0NZ39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ39"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042153314" evidence="1">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="18832" checksum="AA8E4E522C3B6DFF" modified="2024-05-29" version="1">MVQASSFGALALALAGLAAAIPAPDGSGAGAIPTPTGPSNIVNLILPNITERPLFASFVTANAAAATYNLACPKELEQLACEAGKFIGIAQGPSTWGFTMKTGTLTQTLDCALSAGNGQCTGWALRGSETTTFTTALPTYATMEAPVTVTAGLEKLQASSTSSGGGVPRMTQNAALFGVAAVVGGAMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZZ1</accession>
    <name>A0AAE0NZZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_466709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZZ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042143313" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12731" checksum="17F9363CE9484AF5" modified="2024-05-29" version="1">MLILAFWLLGAGSDRGARLYYFRRSSLWPGPSGPSSGEEGTNISNANDDVDSFAFRRGATASNLAWRGLSYAVKRGAMGRPLCVRSRLEITGCAVAEQPDRLTMLDVSEQPRNSSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P012</accession>
    <name>A0AAE0P012_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_125993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P012"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24657" checksum="FEFB63BEAAE51021" modified="2024-05-29" version="1">MGGKKGGVEVGSKKAAGQARKADAALQKKAAEEAKVREAEAADWQKGEKSSAKKDAEKAKKDELARKKAEKDALIAAEDASLPSRAAPKKAKTAVKKTRGLDLSQLDKDGGSGGGSLPALNATGIENALDALLLAGPAADAKIDRHPERRFKAALAQFEERRLKEMETDGSGAGLRNNQKLMRIRKEFEKHPDNPFNQASARYDASKEEVAELKNQERNKIETLLSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P045</accession>
    <name>A0AAE0P045_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_128634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P045"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3390963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="41250" checksum="B61585E2D56BD52B" modified="2024-05-29" version="1">MVTMGTCMSTSGVETEQKKRSQKIDKDLEEDSKRLRRECKILLLGSGESGKSTIVKQMKIIHLKGYSDDELYNYRPTVFKNLIECAKAVINAMRQFDIEPAIEEHKNYCDFLLDYTVESGPQAQIDPKVGVAVQAIWSDPAKEQLMERQTEFYLMDSAEYFFQEATRIVAPDYLPNEMDVLRARTKTTGIYETRFKMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSVVNSRWFMRTSIILFLNKVDIFKQKLGRSPLGNYFPDYSGGNDVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P051</accession>
    <name>A0AAE0P051_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_466126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P051"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="469" mass="52080" checksum="CBE18AFA19719370" modified="2024-05-29" version="1">MSVASISGGLQDMTNLVQSGNYIKGEKYMITKHWNRLAIQLGHWNSGQVIVIDATTFMLMTQGVRDGLANEMARKIGRDAIWVRDYANDQVWVLGPKATISPDISFVNGVQIWDPHHFFAPKPAAKEKIARPPNAFIIYRSEKAKALKSENQELHNNEISVLVGEMWRAETLEVRQAFQKKSELLKAAILKNHPDYRYNPRRPSQIRRRNRQGVTAVSPIVMDANTRAQDFLPPHQPSGWSPVSDPTKNNNNNSDPIPAGLQIPIMPILANGNQMAGPVMVNATAHIPGGILHPDVDPVNFPEGVGIEDLLFDDGNAFDDHPIFAAHLNQTRVYLRNLSNNGGHSETDIADEDDDIQALMAANSSGPNGKLLTLFLSPHPLSFSLPSFSSPSFFFLALFLSPHSLSFSSPSFFLLALFLSPYPLPFSYPLPPFSYLLPTHCITYPLPYATPDIFFPVAPELEVSKMQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0Q1</accession>
    <name>A0AAE0P0Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_467373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261606" evidence="2">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="27350" checksum="98A5198365C49D2A" modified="2024-05-29" version="1">MRSAILSLGALALGLVQAHEYPNCESDGCYRNLIDERFAAEAVSWCPEFLASTTTEASAIPTDFNNCDGNIKAVSSACSCITYTATHTSTPVVSSTSVPESSTPPPASSTPASSTPEVSSTSAPVASSSTPAASSSEIVSSKAPVSSTTNPGSSIPPASSTGYTGPWTTSTILSTTTYTVTKCPVTVTNCPAHSTTVTTEIITIGTTVCPVSVPVSSTLTKYSSLYSSVGTVTAPPKTSSTSTSSVPVTAGAGRIAHGVEMAAAAAGIFAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P107</accession>
    <name>A0AAE0P107_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_467635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P107"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3391279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="711" mass="77101" checksum="D5410DE4862A850B" modified="2024-05-29" version="1">MTSLGQTFVSKGIQASADNLAIPEFWFAIICQGPDRSWLLLRDYCFFPTHAAMASLLRQIVAGPRAKHQETGLDLCYVTSQIIATSGPSQTYPQRAYRNPLDRLVTFLDEKHGDGWAIWEFRAEGTGYPDEAVYNRIRHYPWPDHHPPPFRLVPMIMAGMRNWLAGGELEGGKVTAGEGHEMKKLSAEEQKKINRVVVVHCKAGKGRSGSMACSYLISECGWTPEDALARFTERRMRPNFGAGVSIPSQLRWISYVDRWTKGGKKYVDREIEILEIHVWGLRHGVKVSVEGFVEEGKKIRVIHTFKRDERIVVEGDAPGGAGIMDLVSDMTGYGAESSESDEAEDPDFNEIKDGTSSKNDDINSEDTPVAVAPPARSASKKLKASKTTHLMKKLSVRKKTGSSQSLSKMGASGKSKTIAMPDPSSQTAASASSLIPPPDPESKSTTSLQNSFSFADSSEPGGQAVIFKPKTPVCLFNSDVNIAVERRNRAPASMGLTMVTAVAHVWFNTFFEGNGPEQDGRADDSGVFEIEWDKMDGIKGSSRKGTRACDRLSVVWRVVGTTGVDEEAEGHVVSGVTINEPGEDSPVPQMQAADWKGGNEEDPTADKHLGLRVQDPDSASVSKASSIKSLEIGGNGKEVGEKTRGDRDKNGDQADDESLAGVKISGPAGEEVLDELAPSTSTKKGDKKLSSDQLPGGEKADATAKNGFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P156</accession>
    <name>A0AAE0P156_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_508451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P156"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="14762" checksum="A408E431E5FA47CD" modified="2024-05-29" version="1">MRYSDMSSLKRASSVCLSIICQRRSREAEVPNRGPPALPAPLRSSNYKFSAEQARTVPPEEDHIRPLPGAFAKTTPDGYNVSELQGRAPGVVGVGSRRKDCGVRGPEHLEDPARVLEMPGSSVIGGPPLIETALSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P415</accession>
    <name>A0AAE0P415_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_457273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P415"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="705"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="938" mass="105163" checksum="1D5F43451437F623" modified="2024-05-29" version="1">MSAATASAPQPVKLSLPLVYQQKLFEELRNEDELVILARGLGLIRLATNLLHSYDAAGNNLIVIVGAEDRENAWIGEALAEHAAISMTPKARGLTVVNTDFTSVSQREKMYAAGGIFSITSRILVVDLLTNLIIPESITGMILLHADRCVATSLEAFILRIYRQKNKAGFLKAFSDNPDPFTIGFSPLATMMRNLFLRKASLWPRFHMHVAQALEGKKKAEVIELEVPMTDAMKEIQTAIMECVEVSIHELKKGNTGLEMDDWNLDSALLKNFDVMVRRQLDPNWHRVSWKTKQIVGDLTVLRGMLQSIVSLDAVSFLQQLDTIHAAHSPPPGSTRQTQSPWLFLDAAQTIFDTAKKRVYSSNQKAGPDSNIDSLRPVLEEQPKWALLAEVLGEIDRDLYFEPAVRDDSNGTILIMCSDTNTCRQLRDYLQTMHVRPRTEKRIEEFHDPEGDKPSGAFMMRRKLRNYLRWKGEFAHVSATLFSENQKALSGAVDPRLAQSKSRAPANKRRRVRGGGNAGAAPGRLENGSIGQFFEKPSEVAELMAEIQITEEEAKQKDDVIADPLEDMDDYYQMYEMQDLVVIHAYEGDQDEHVLEEVKPKYIIMYEPDASFIRRVEVYRSSHNDRNVRVYFLYYGGSVEEQRYLSTVRREKDAFTRLIKERASMSLVMTTDAQGVEDPQEAFLRTVNTRIAGGGRLAATAEPPRVVVDVREFRSSLPSLLHGRSMVVVPCMLTVGDYILSPEICVERKSISDLISSFKDGRLYSQAESMFQHYKSPMLLIEFDQNKSFTLEPFADLSGSMASVSAANAGANDLQSKIVLLTLAFPKLRIIWSSSPYETAEIFERLKTKSPEPDPIAAVRAGLDNDTLAEEQAFNTEPREMLAVVPGVTPKNISNLTLATESIKEVANMTTEELAPLVGKEAARKMHGFFNKDLIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Q5</accession>
    <name>A0AAE0P5Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_555185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44074" checksum="026BACC142DAE418" modified="2024-05-29" version="1">MDSLKVVVVASPFANMSPLYEVDPEADVLLIVPPNNKPFAPWNDASSGPGQVNGLGINSKASPPPSPGLRIKVSSKHLTLASRVFKNKLQHGSTRSSTQSDGRVHLTLTDSIYDPKAVTAVVNAVHGRGSKLKTVRVDLATLAQIALFTDTFQLFDTVEVYADRWIDKLLQDEGLPDLYGRDLVLWIFISHVFRRADVFKSVTKLAAVHSTGPIPDLGLPIREKLIKHIDAQRQELAGQAITSLHGAMDTLTSGAATCPKFQCDSFLLGELIKTLHKSKLVWPRPAKPLTGVSFGMIVAAVSSSTQYSESQRRIIPAAAELWNDAARSHPAAVLPSRKRKSPVQQPITPPDSSPEPVARSVPGSGAGGNSFESHDCAARKLMGDLDGLEALEDGVKGLELESSLGYQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P673</accession>
    <name>A0AAE0P673_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_34192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P673"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="187" mass="21471" checksum="9C041FF4A1D6D103" modified="2024-05-29" version="1">MSLVLIDEECFFLEGLDHHRQQTRLQHPVLRNYFSSFFDISSVNGPSSWLGRLLVCSVVSVILTLGKKSHLTCCSDWSLTNGTSGTPRLLVYCLGRRSPSTCSGLLGAVWLEQWPRQSATRLWPFVQSDWFKIGSRSLRGHAQHYSSKQHYFSRTVPLFFTMHLFFTISFHSLPHLHLSHQYSLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6I7</accession>
    <name>A0AAE0P6I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_38773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6I7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="162" mass="18515" checksum="D3D4B98CC0B628B1" modified="2024-05-29" version="1">MRSPLRYLCSRSHTRLPRQAHPKRRRSVWTCFFQSQVLKKQDGPCLQEPNQLAAWSGLVPISHPFAVRPFCCVAGFVTSVSGKMLTDEGQLGALLRGWGTLVLLTLCCWRFRSSLLPPYEWMSPRLVCGSATLFDLDLLRRRTILRRNTATMGWTAWYSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6K5</accession>
    <name>A0AAE0P6K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RWD, RING finger and WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_426202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1541" mass="170012" checksum="73013CD201AC797C" modified="2024-05-29" version="1">MPSALDRLSDHPKKGKSIKSAFDSESFDADGTIHVDGLVGSATISPSGRDVALASPEGLTIIDLDSPWSPPRRLSSHGLPWLVVDVQWSPFAARDYWVASTANHRCLVWNLNLRDDSSSGAIEHSLQAHTRAITDINFSAHHPDSLATCAVDGYVHCWDLRRPRQPVLTFCDWFAGATQVKYNRQDPHILASSHDRWLHIWDDRKTVEPLRTISAHTSKIYGVDWNRTRSTGIVTCSLDKSIKFWDYGKGDELPERVIRTDFPVWRARHTPFGWGLLAMPQNEPGNLYLYDRRSAPDVPIDGTVEPVAVFPGHGNHKVKEFLWRNRGGVSSDGMDNREFQLVSWGEDNLLRLQKAEPKFLESVGYVRGAPVRKNLNITRKGAIYKTFRTVDDSVHRDRRSPTMSDPRPGSGGQYRPSALSLGLHTRLRRVGPMWKTTSMKAKNNSGKDVDKSQLQIGWMKGITMSKRKPGSDTPGQFGSKDGGLFSPSFDDGWGEPETIQDEFLRISNRLPNVKWENIDMDALTLNASLKGPWGENGETIFIKVKVDIPTSYPKVKAPKFLIEKTSFMSDDVHKKIEHELQELANRFLKRKQNCLDVAFTYLLGEVDLENSTSFFKNVRDLDDELDVLADESSSEDDENDIPTGGSASMSQELTASTELDPTTSLAPTQRPAVAPLPRYCGARFSNDGRLVCFFPTKEEKAKGLFAVPAVDTYRERPKGEPTFAGFGRLSHDSPPPKHRFLDDTSATDDQSEESDDSESTSSTDSEPTTVHKISLWYQPGRHFKKTWSADDSMRSSGGGTGAGTGTGTGTSRKKPGKPKNSITIYDLRSELPSKKEFAQEYAIFGDGADVCTHNAIVAGKYGYHDLVHIWNYAAMLLRNDIPLELHEQQHRNESILVIAKEVAGRTRDGGSQSGSDINLSGRVRWGHHPLAQKLIDDLFDYFEGMGDVQMLAMLSCIFGDSTAEDSVAYAESHLTQPETPLPMKAPSFSLDYFPTDPALWNIHYRSHASSAVTTPRTAHTPVLYADSQGSDEVIGMIEHGSNSYSCGETPPRFGRDHLRDVDHTQSLSTSPNNRFFHRSNSTMAAAFAASLPRTLAGIVSGSPPEPPRKRPSPADTILSNLAPSSITWGASTVFGAAPEPPGTARTSLSDDDFRRDELLCMVPVAVSCVPENQFLFDDDGWLSTPLLHPNRSQLYSNYRYAYAEMLQMWGLPLSRLEIMKFNVLKDDRHSASSTFGTADGSLYEGHPADKNHSHTTNTVTSSPSVPFGGRKEQLQSLLDSGRGLDVTGICRIHETQLDPVEYSRPTNGQVGGAVGICHRCQSHSKTPQTLLRCVYCCEPIDALYPPCLCCGCASHEACLAEWHAMGETECPAGDECQCIDEASNGQVESWDALWARLRSSGNVARTIVERGSPPSKQYSNLKSTERARRRSVPSDLAKAAGLVIVDEEDSGRGSSAERRQRRGANGDNDNTIDREDWESVASSQGIPTITLGGKPPPRGDEPISAARLSLGNRLKKSLGESGRPSALRRKSGGVPMWKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6T0</accession>
    <name>A0AAE0P6T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_460746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12184" checksum="E39C1F0211BC62A6" modified="2024-05-29" version="1">MPTPESAAFLAKKPTVPASFDGVDYDDTKRLKQAQDAIIREQWVKVMMGRLVREELSKCYYREGVNHLEKCGALRERYLQLFKENRVKGYIFEQQNFYSKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6X7</accession>
    <name>A0AAE0P6X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_426453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6X7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="501"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="691" mass="75794" checksum="DDE6D8EDBA7A9FB3" modified="2024-05-29" version="1">MQQRRDEILAKKAKLAELKRQRELRASQATATRQSIGTTSDLISPTPGRAENRREIESLINSLVGESRPVSVSTGANSPARRGSRPNSVFSTGELSNETSEFAAPANSQVATSQPQILTTTPLTTVYECPPSPVKEVFSYSKGVQTTEEWTTPPSRPRAFSESDNEEPAATPSKRLSRRERDREEELRENLRREIEEELRATKELVTDGVLKPSAAPNFPARALTAEELKAVTQSDDFMGFIDRSTKVIEKALDQEYDILTDYTLQVYDIDDDDEQNGNTGGKGRRKIKELAQFYDERWSKKRMISSIDFSPKFPELMLASYTKNPTAPHDPDGIVQVWNIHLHDRPEFVFHAQSDILTAKFSPFHPNLIIGGAYSGQVLLWDTRSRAAPVQKTTLTGSGHTHPVYCVDIVGTQNANNIISCSTDGAVCGWSVDMLAQPQESLTLLAPLPTKHEDLAPTCMAFPEADPTFFLVGSEEGTIYPCHRYDRAGAKAGVDSRVSYKGHAAPVMSVDFHPARGPLDLGDLVLSASLDWSVKLWKVRAPAATSAVGTALTGNPEAHVAPLLDFVREDVVYDAAWSPIKPGVFSLVDGAGWLEIWDITVETEEPVARISPSLRKDGRTMLSKSLNKVTWEKSEGKRLATGGIDGTLTLFEVGPDLGGKEGLKIDDWQNVKKLVNRIEAAGGVNGATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P771</accession>
    <name>A0AAE0P771_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_51310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P771"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042204132" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="38359" checksum="68D198337975FE21" modified="2024-05-29" version="1">MRRPQSPSSLFLAQLLLLAGSARNATAHPYPRVVEVIRVRDWQSFTTTWTVTQTFTSTGSTFIPAATGGAGGGGNCIAPAGSGQIECGPICCTNQQYCAYLGQCYPNVPGGGGGAVFPTTITTGGQVITTQFSAPYRVTSGTATGTGTAASQTTTDGVTPGGTAGSSLSGGAIAGIVIGTLAGVALLILLCICCVFRGLWHGLMALLGLGGKKKKETTVIEEERYTRRGSTHSRRDAHGGWFAGAGGRPSTVASRKEKKKSSGTGLMGLGAAIGTILLLLGLRKDSKKKKASHKTRSDVSSSYWSDSYTADSPSSLSSDRRTRRSRQSRTSRVTRTTRVSRGPSVGPPPRSRSRRSRSRSRSPLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Y3</accession>
    <name>A0AAE0P7Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_385975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="264"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="600"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="709"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3395026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="881" mass="100333" checksum="68E3808E75252D07" modified="2024-05-29" version="1">MHDADKICYGMLYRQDVKLISQSMLALVTKLQENAGTNTNHVQKFKLTPKAVHVLLSLPDGSEFGYLRPAMTKALVPLLEKGPAIEVEAVAVTSHLCQQISHATKPEEALVQVNINIYGPQNCDKEIGDMLSDQKLWLQRPDHMRAKVIYKNPHALSFPEIEGYLQEEQVAKEVAAASKPRAEEERLKILVKSVENALSRASELDNETGDQRLTTELLKHQQRALSYMLQRESGEIPEKYRLWEPCTFRGQDMYIHRITKTRSIIRPEEKGGGVLADEMGMGKSLSTLALILRTLEAGIEWAEHKRTEEHVSAKARRPSHSTLVIVPSASRLILIYSRHCGDVLKTVKYHGHSRKKDLDVLEKSDIVITTYNTLAIEYALKKSVLHKIHWYRVVLDEAHIIRRPATTFHRTCADLDARSRWCLTGTPIQNRLDDIGALFSFLRAEQFKSLAQFRRFISTPFDNGDPVVKDRLVLLYDSLCLRRTKDILDLPGHVERIRELDLNESERLQYDKTLNILNRYMRTQVGRYHDETGHTITGDGQSWKGSKFGLFQAHLQLRILCNHGTFQKPFSWKKRDLKDEQSAEREAVVGEFGLKSEVMCDGCQQPRPILGSTHAQNNFVENCAHSLCSDCLEDCSELTGMQDMRHCPLCQRFQVTLTNASAQIQDTLTQTEDGDVQMQDVPDNDVARDEANKNTHHKHYFNPNGYSTKMAKLMEDVKKNITDTKSIIFSCWTKTLDLIVRHLEQEKIDYLRIDGDCLLSKRQPIIDRFENDKGVQVLLMTTGTGAFGLNLTAANRIFLIEPQWNPSVENQAIARAIRLRQLQEVQVTRYVIKNTVEQEMRSQQILKRLAADVGFKREADNAGANADHDMVTTTLVPGNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Z5</accession>
    <name>A0AAE0P7Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_533368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Z5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="113" mass="11910" checksum="8F69E87FC27654C0" modified="2024-05-29" version="1">MSQSGMSYHHSAADYSLSDSWQTSASASTHNPTAMMYNIRQVAGQSIALNNTSQQFSQQQPASLQMTSAEVAAPYFSSEPTNTAAASVMQAQTASSSTQPSYLQNYSASGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P858</accession>
    <name>A0AAE0P858_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_556175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P858"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041967362" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="623"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3395084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="75406" checksum="AEE65BAAB54CE5FA" modified="2024-05-29" version="1">MFFFKALLIIGGFVLHAKLASAAISVSNTILVLARDAAAATSATSGLQGYGIPYKVAIVPESGITLPSLSASVTQGNYGGIIIMSEVAYPYPAGWGSALTAAQWQTLYDYQTSFGVRMVRLDSFPSTEFGVTTAVGGSGCCNTGVEQLVSISDDSSFATANIKTGASVSTLGLWHYPATIINATVARSIATFASDSVGAFTGNSVAAIINTFGARQQMVWFMGWATDWSQTSNFLQHAFIHWMTRGLFVGGRRLYLNTQVDDMHLETDMYLPRGTTFRVRTSDLNTHQAWQANINTRLPSGSNYFIEIGHNGNGAIEAATSLASSAGVCIPPYGVEYDSPPDTPLEFQKPLGTGTDLWPAEFTKSAIPWTVACSKLDSIANWFSNNPNVFAAVSHTFTHEELNNATYRDADLEIWFNIQWLHQIGLWDASMFSPQGLIPPAITGLHNGDAIRAFLDNGILYVVGDNTRPVLRNPTNSFWPRITNSADNGRAGLVIIPRWATTIYYNCAFQNCTLQEWIDTSGGSGTFTTLLNDARTVNTRYLLGLHPDPFMFHQANLRSGDVDPITVGSQSGRLSLLQIWVETITQEMVRLTNWPITSLKHDSIGRLFTSRMARDACNPNLTYNYSDDGKTITSVTLTATGNTCDVPIPVTVPDRATPSGNGQTTFEQLGSDPAIYWTSLAGSPFSFYLSSPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW54</accession>
    <name>A0AAE0TW54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="71" mass="7499" checksum="BB367CC947AEFC43" modified="2024-05-29" version="1">MPGESPPPERVADKQMHATPASGKGTDDASNKEQTNKDALSKLTSNPKGPLDDIVTQKFAKTASESDSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWB5</accession>
    <name>A0AAE0TWB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_218690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWB5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3382029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="165" mass="18236" checksum="B0DD40D25004A147" modified="2024-05-29" version="1">MLREVGGQCPLGRCSKGAQSPDHPRRTTALTPSGTPLKLPVTPSTYRGQPSLVSLRRHSQACLLMPSLVVAATLSLSEHLPVHTSTIPPSHRLAHQTHQPTTSHFHGDRLATVLFATHSWLHMSLMHRILHTPAHLPLTYTNLSHIKHTHQHVCCLLATYAARQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZG6</accession>
    <name>A0AAE0TZG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_522535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZG6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="85"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="215" mass="23259" checksum="8CA0836E61B3F30B" modified="2024-05-29" version="1">MTRRSFFSSASNASSETMISDRLDEKTLPFRSKDGTPSTAKPPAASIGPSPAVEVHPLESLDGMIVKIQPPQHPLDPQLEHVPCDIVLVIDISKSMATEVSVPAQPGETEERTGLSVLDLTKHAARTILETLNKNDRLGIVTFSYTARCMQNLIPMTKRNKKSTSKKLDSIKPDGMTNLWGGIQEGLRVFNEAAASSNGSVPALIVLTDGEPNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0V4</accession>
    <name>A0AAE0U0V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin variable region used by the itc63b heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0V4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66702" checksum="C9F4CA3824A34E5A" modified="2024-05-29" version="1">MEDAVCPSRDALLAAFGGSFRAWSTTVPGDAQRDCERAFRALEKLASPATFPNLPSFPNPLTPTEKSGDYFASGESLWDAGDCPSCDLGVTRRRLRIRVSATRPVPIDITTNTTKTSAFPDWFGSADNHVSVLVLAWAYILSARWQEIVTGPPALRYTPKVAPPASQTDKPQVVHVHIGNVTAQAQRWWEAVLAPDNGWAALICPGSLSPWAICLPSSPRFAIVSSPPTTHSSTLPKVASFAEASRYLLDYCILHGIVHKSWAALSAALFLPLANWERSRIRLPVSGLPSRTIPKVMQRPPNAGQPCPTSQLDKLLLLSCHVRGLSAVLSSIFFNPDIPCNLASPWLQGAFAVIDNVSHDRHRLATTLIDRNPEIGFLWIGAMITGQDKRIIDCARGSGTDLHSAIWTGTVQNFIQLPPPSSAVSNGRINRADECRLLFLASDAHSPYLPMSPWKPFGSTDLEDTDLEVRLHVKCRGHRLRYRGWSWSGTKGTIGATSNSHTPGIPSLRQSTNVTIPYDVLDLEDNDASANATYNAFRWLRMEGFSAAEQHIRRHEWVCDYFDDDEAEGYESHWTSDEDKKRAKSAGPNKPKLAQWLTIGNSVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0X7</accession>
    <name>A0AAE0U0X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF2828 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_468476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0X7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="2">
        <location>
            <begin position="139"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="3">
        <location>
            <begin position="569"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="92043" checksum="80106A82A711EBA5" modified="2024-05-29" version="1">MDAKEEKTDTKWFLKAQCPVFWPKTDALTLPDDRFAAYLTQTVNSTRQQDDGPAKTDVDSDDGTFTMVSEQPSTTADARAELEKMAIGSPKATATANPTADANNKEDAAPAHPFMQGLLSHAAADAGPKETDLENKMLTDNGDVAFRSTKEALVDLFFELEEAVSAPRLLELLKLAWKDDALATLKIIFNARSIHLGKSSRLVFYRCAGWLAENHPLTLVANLGWLSRPVIQKKVEKKDEDLDDMVLIELEKDDSDAARFDVRNGVAHGYWKDLLNILALSVNEKLSVRANPREILNIEREVDPETGRKVKKTISQDAAKEMRRELRDMRHDAALDAFKNKPVHHALHLAVARLFAEQLKADIAVLRGDGAKAKRTISLCAKWAPSTARFHDKHTFIVSSIAEILYPESHFNPADLVAGDEKEKRTIYLRHAREAYRKDVAALRKHLDVVERSLSANTVGQVKYERVPSQAMNNYSGIFATKDTDRFEQYLDKVASGQAQISGATLMPSTLIKAVRTGSQSSAVVSSGCKKRSHKQMIADRMASIDAKKIDGQWNALVKRIKDSGTLQSSIAVCDVSGSMLSPTLADGTTPMDSSIGLSLLLAEVTAPPFGGAFITFSEKPAVEQVDLKGTLEEKYRSLASADWGMNTDFDAVFKKLILPMAKANKLAPEDMVKRVFVFSDMQFDEAIVDNSSRWAPKLGATGSSKWATSYERLQKEFKEAGYEMPELVFWNLAGGRAGNQGGGSWGGDPVAPKPVTADQEGVSLVSGYSQGMLKVFLEKGLFDEEEEREGVAMGEDAEDDLVAVEKTANKPRANPLQTVKKAISHKAYDMLKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1B4</accession>
    <name>A0AAE0U1B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_468715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129974" checksum="4697DAC4C1B13B59" modified="2024-05-29" version="1">MDARPGAAVVENQYARDASRSSDSLPEPPSKRLRIDGGQTHPTIWSSKAVLTECLKTQVFPHIEEHISRELPGLPDDVRKELGKQVVALVSGPEFSAEYKRGNGRISPQYEQHVSARALAEVRALARHHNLRVNTPGAVTHVPVPAPPARLSETPIHPPPLPAGIRLPSLPSPSVQQRRPAAPIRQSVEAPRFSHSPIPVPVIPNRKPAIPNGVARDQDGGRNHNPDVRANRFKNSPVVIVIDDDNDDDSKHLQLLPLKKPPTALPPNLSTPIKSEYPPEPHRIPPPANLPPVTPPRANVKGKLRGHVPTSPANFRSRAHAAVWRGQHDQAVDDGKAHTRSSWFPQGKQPYICSEMRRGIINGAHQFIRLNHGDLFQPVTFHVDFTLEEVRCLQVLTRQILGLPTEKKKKDLKKDLQRLLKKNTPHIERVLKAAVRENRLPRRSKSDIAHFFKDVMNQKTASEPMLLRLQRDDYDRQGDFVRSSRIHSLLFAREISGHRGYGSMRRPENFSNEFRKCREDSLELRSEWTDCAGDISTIVWVSDHSFICGTTEHSDSHNQQYNKPGNLVLGSSSLGTLRAYPDHRIVRPIVEKGENSTDAMIQSQDPWLYSSVVSSDYDSVHDRAFTSGFDRTVKVWRVEQSGSAMHLLGEWRHGGNVNFVATSRHESGMVATAADVAQDAVRIYDISENAVSGSPFRSYSCSRITDAEGNSVSTEKWAYFPATMQWGRHPAVRHMLLVGYSPRSRTNNELDIPEDRKDSGELCLWDGLTGERWKITSATTQNVFEVLWHPTQPWFIAATSPLGLEIEDGVRTQIRVFRETDNPDLGGKAYSPIKTLDCAALDINELTIMPNSLVFCYITAGCTDGNTYVWDTALGDKPIHVLRHGAPIEEYRGDRECEDVGVKFTAWGTTPDRFYTGSSDGVVKVWNVRSLRKPLVRDLLEVPGPVSCGMFSPDQSKLVIGDATGRVFLLSFDQDGQGAKQPSFMRVQPPGARTSRTVRRPMPVMQHKEPPAPAYDAAGRPIEPESGPLRAKTYLAQQYLRIHPNPTIGAVQGPKYAETGLFLPEAHLNNDPSQPLLARWEVTQQEAKGGHEARRDMFRKLRAVKEAPDLASLHSKNANLDLKWEGISDETKLELQREGVKEQYITNPDYALHYEESSSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1I7</accession>
    <name>A0AAE0U1I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_448027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1I7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="571"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="669"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="742"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="814"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="850"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111563" checksum="C11BE69718852855" modified="2024-05-29" version="1">MDDFFRTQQSPRGGETQNQMNAAAFVTTPRNGPMLPRRFTTDSGRVPTLSSITTAQRGNESQDFAPTNAMHKVQLLEKKRLDYERLREHKRRFEAEIHKLDAQQRQEERELQQMQEDLQSARFAGHQSEPTTPPEYRESSSGFPTMFSRPNRYSTSSLTSPPGLFNRPGRSGSQLQSPQAGLVQSRFAFDDQLPSRSVPGSRRNSDEDEKEEAVRQDPTSHRSTNALNRYSMPVTRSRTYLDIGLEDSNNTTGFLFGDEDSNSGETRTTPTAQASNPNAFPALYQQQGYSNLIPASSSALDLTQAQSSGPEATTTNGWNSINKHRSQQSMSTISSTPLNGAGPVSSPSEVSTIGSRPSNVRHSLDGMKFFENASNNADSSPSVVSPPTNHIMATPPKLQQSYSANDVKSSNGTPGLGSNANNHAQQHFHNHNASLGRIPAGAMPHRHSRELSSDASMANGRENGAYGSITSTLHANATPFGPPVPLQSSAPGTPGMTSPTAGVPYGYFNGATYGAMNGGPAGYNNLPMLMQSLSVGSTAPPSALYSPQNYTGYGPLYNQNNNTTPTRSQDSQARVIQNRRQMDSEAMARFQGLSLESVGGTIYTLCKDQHGCRYLQKQLENRNPEQVHMIWLETNQHVVELMTDPFGNYLCQKLLEYCSDDERTVLIQNAASDMVRIALNQHGTRALQKMIEHVTLPVQINTIIEALRYQVVELIQDLNGNHVIQKCLNKLSSKDAAFIFEAVGNNCIDVGTHRHGCCVLQRCIDHADGLQKVWLIECITTHAVTLVQDPFGNYVVQYIIDLNESTFTEPLVRQFKGRIAMLSRHKFSSNVVEKCLRCASDVSKDMIVQELLSPSEIDRLLRDSFANYVIQTALEYATPMMKHHLVETIRPSLPGIRATPYGRRIQTKIQTYDSRSGPNSTGQVTPVDPASGQIGLRPTHGRAMSNSTSILATGAFPVAGNGTSGNGNGRPAGPTYPGSANITIPPPQPQAPPQPPRTQYPAQFAPLGAPTGSEEPQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1V0</accession>
    <name>A0AAE0U1V0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate oxidase from Microdochium Nivale in complex with substrate analogue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_509494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1V0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042079279" evidence="6">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="497" mass="53890" checksum="E2A86029762B8EB6" modified="2024-05-29" version="1">MRTVIPFAVGLLAPLAQGRAVVTRADIESCLTSAGVPIDVKGSAEWARDSAPFNIRVPYTPVAISVPTTAAQIQKSVLCGKKLGVKVSAKSGGHSYASLGFGGEDGHLVVELDRMNNVTLGKDNIATVQPGTRLGHLATELFKSGRAIAHGTCPGVGISGHFLHGGFGFSSHRHGLALDSVVGATVVLADGSIVEASEKKNSDLFWALRGAGSNFGIVASWRLKTFEAPATLTWFGVSLGWTQSTAVAGLEALEKYARNVMPKEINFRVSDYNRGSPGIEGLYYGTDAEMRAAIAPLLATAAPLANITDSHTVNWLEAAVHYSFSDTGIDWVLPSPQEIFFAKSVTLKGLSGKSAQNFVDYWFNNATQLTSRNWWFQLDMHGGKNSAIAQVDNDETAYAHRDKLYIIQFYDRIDSGIYPTGGEKFLNGWVDAVTAPLAPSDWGMYINYADTTLDRETAQRVYYGKNLPRLQALKAKYDPKELFYYPQSIKPSTKKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U497</accession>
    <name>A0AAE0U497_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_538204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U497"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="35506" checksum="8977BD8E36296E16" modified="2024-05-29" version="1">MSRASPIRLASPPHFLDARNCAPTIIAEPHAILRENWPCSPDPAPESETNGSVWTACSSPSAACTRTSWKPVFAAFPSISTAMAVIIPSEAGYFLHTYSWSYFDADPASRTNHAEAKHRLASDLGGGTPLSRHASFEKAGPLPGKPQTLSKHIRSLLGIRASLDGKKEHLWRAGNPVYLRVLYQGSLSSSPLVIQDAIQLPTEEKILPHEDRPKYMKKVAYKQEQDGSRTYRLIAVVRLRSSPQKMDRIQTYTRFGDCVRPENMGVGVGSVAGEVVGNSGTPTSSSRRKHLIGGGGSSSSGTPLDGDNNPYDDEKVVSERDCLALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4K4</accession>
    <name>A0AAE0U4K4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_122386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4K4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="27393" checksum="14935F84128E952B" modified="2024-05-29" version="1">MTTITIGVLALQGGVAEHLSLLRKAAATIATSEFQFTFIEVRTTDQLAQCDALIIPGGESTTMAIVARRLGLLDPLRQFVKIDCKPVWGTCAGLVMLAEEASATKQGGQELVGGLDVRVLRNRYGTQIQSFVADLKLPFLGGDAEPPFRGVFIRAPVVEEIMTSSSARTSKQAVGEGQVDGEGKKSTPVEVLGVFQNTEASTGGADEDIVAVRQHNVFGTSFHPELTDDVRIHVWWLKQVLDAVRHKNLVVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4X3</accession>
    <name>A0AAE0U4X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_539858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4X3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="460"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3391193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="696" mass="77341" checksum="DF76DD4159142C67" modified="2024-05-29" version="1">MDAIAETAESNVDVLIIGAGPAGLMAAAWMAHCGVKARIIDKRNTKIMCGQADGLQCRSLEIFDSLGFADRAWKEAHHMIEICMWNPGTDGVIRRGDRVPDTIVGLSRFQQIVLHQGRIERFFLDNIKKYSGDSIQVERCVLPESLEIDESKVDDEAAYPVTVKLRMLKEEEATPQQQISGSTVTDGLFRSNLIQEDDEDDLIRKSKARAGASEIVHAKYVIGCDGARSWTRRALGFELKGEATDFIWGVMDIFPITDFPDIRMRCVVHSANSGSLMIIPRENGLVRLYIQLKEVTPDASGRADKSKITPDVIFSAAKTILSPYKIDHEYCDWWTGYQIGQRTGTHFDAHGRVFLAGDAVHTHSPKAGQGMNVSMQDAYNLGWKVALVAKGVCRREILNTYQSERRRVAQELIEFDHKISRLFSGRPAKDVTDAEGVNMEEFKKDMFLKGNLFASGLSINYGPSSLVVKPGDAAELGDGSAKSASLAVPSPITVDEFSKKQALATGLPVGMRFNSFKVLNQSDARPWHFQERLKADGRFRVVLFAGAILSVAQKHRVDAFCAALDAPGSFLRRATPPGQQVDSVVEVLTIHSSKRTDTELLRDFPDMLHPFDKYKGWDYDKVFVDDVSYHEGFGDAYTNYGVDKEHGCVVAVRPDQYVGWVGDLEDFEGLQRYFEGCLVLRDGTVPENGAKAEMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6N8</accession>
    <name>A0AAE0U6N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_516101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6N8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3392887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="26916" checksum="55B32F3FC8FDC080" modified="2024-05-29" version="1">MNRLDMWVWLHFLIADRSIYENVLHFEVVRKKMVAKNDIDGLAAEARRKLNLRVAAEHGSTALATKEAVDCLYRADSALRESMRTSDVAVVNLYHDVVSGHDDIGNGVRLPAGVRFAFPTQNIHLDADNYPEPLRYDAFRFSRLFENIDAEDKEQDDEEQLLVTKLTPTFLPFGYGRYACPGRWFATQTMKQALAYLVTYYDVELVGKPVKRRVLLHAMVLLVDAINANSAQILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6V6</accession>
    <name>A0AAE0U6V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_13277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="413" mass="45480" checksum="0252E2D52D6A9BD8" modified="2024-05-29" version="1">MAPWVPSLRSQTTTGSCILMGVFGISIGLALRSLIRHKRPSKKGLHIKSPRETQLPKLSQDEIAALSYPPNVLPGGRDVETPYGCIKVFEWGPEEGEKVLLMHGISTPCLSLANLAEELVNEGYRVIIFDFFGRGYSDAPSDLPYDMRLYTSQILLVLASSNLSWTGDNKFHLIGYSLGGGIAVPFAKYFPHMVQSVVLIAGGGLIRQDHVSWRSRLLYSTGVFPEWMLRSLVRQRIMPARTTDMTESKMASEVVDVKPSTTHRNSDASGGDSYDNAMLLMRRPGHTVSSVMDWQVHQHQGFLTAFMSSIRHAPIYDQREDWLALGQLLSQRRGSSDSQIIGTTKLPGLRGGRVLLVLGSADPVIVKEELIHDATAVLGEDGFEAVFLECGHEIVMTRGKEITALAVGFWGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6W1</accession>
    <name>A0AAE0U6W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_386431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="751" mass="81969" checksum="8E7B4CF24DCA0E9A" modified="2024-05-29" version="1">MSSMNSRLKGFGFGKRKSTAITQNQNQNFHPDLSQPRTPPLGGAPQIPPLFPSGPAPSIASTSSQQSLQMNHPGSGPRPPSYSANYPPGPPGPVGRTSPLANQGPARTPPSQMVGGPPPINTGAPPVSGYPPPVMGGGPPPIPGGPPGYAGGAGYPPPPPQQQGPVAPYTRNAAAEVEGNSRSKAQLIVGIDFGTTFSGVAFAFATNNEAKEDIITEWPGAGSYTKQKIPTVLYYDQYQKVVGWGPDIADALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRAALQKTLGEVFNREERNIRYYLTVPAIWNDAGKAATRAAAIQAGFLRDENDNRLTLVSEPEAAALFCSKTGLLNLKVHDAVLIVDCGGGTVDLIAYEVEDENPFTVAECTAGSGDSCGSTALNRNFSNILRTKIRKMKLPDGSKTAGRVYAKCIMDFENRIKADFRNNGQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRTLQNILVVGGFGASEYLFQQIKLHVPPQFQSKVVRPMDSVAAIVKGAVTAGITERVITHRVARRHYLMATLQPFKEGYHPEAYRVPSLDGKDRCKFTRQIFVQKGQKVKIGEPVKVSFFRQVAPGATLMYEDILYACDDDVCPEYTKDPRIKEVVTLTSDLSRKNLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFSAELVCQGEVMGRCRARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U753</accession>
    <name>A0AAE0U753_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_16814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U753"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169863" description="Zonadhesin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63247" checksum="0B7199B77146F88D" modified="2024-05-29" version="1">MHFSSSLSLALAAFAHVAIATPPPQVVTETVVSTVHVPTTIKETVKETIKETVHVTIPTTIVHTMTQTEVKTVHVTVPVEKLVTKTEQVHVTVPVEKLVTKTEERMVHVTVPVEKLVTKTELKTELKTVHVTVPVEKLVTKVEVSHVTVPVTRTEIKEKLVVSTSVITKVDVKEKLVTKTEVRHVTIPVTKTEVKEKLVVSTALVTKVDIKEKLVTKTEVSHVTIPVTKTELKEKLVVSTSVITKVDVKEKLVTKTEVSHVTIPVTRTEIKEKVVSVSVPVTRTEFKEKIVTAVVTKVDVKESVVSVTVPVTRTEIKEKIVSVSVPVEKIVTAVVTKVEEKFVTKVDVKNSVVTVPVTKIEEKIVTKVDVKNSVVTVPVTKVEEKIVTKVDVQNSAVTVAVTVTKTENKENVVTRTEFKDRVVEKTVTYFQTAVHESVVVKTETLQHVVTETVNGAVYGAAYGTGYLASAQTSTVTVHVTLSPSECLAAAATTQHVMPPPHTQAAPPMVHTQAAPMAHARPVVVVSEVVSEAHVALKPLPVVVPPAHLASPPLPVVSPPHAPMPPHVPVSPPAHSMRAVKFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7S6</accession>
    <name>A0AAE0U7S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">B0H63DRAFT_505572</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7S6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="434" mass="49631" checksum="AF3DCADFC47FD798" modified="2024-05-29" version="1">MTSSVKTGPTTKGLQRFAIPFVCVLIGFLGYYSQYLFYTSLDLAPGPLTTQQAAIFNILLACLWWTYYKACTVSPGCYPSTTTPPPYARHCKKCDAPKPPRAHHCRHCGRCIPKMDHHCPWTGNCVSLQTFPYFIRFLLYTNLSLWVLGYHIYERLANIWAERHLPAYLGPTLPHLITLTVMSMVCLGTALALFLLLFTTARGWVLNATMIEEWEMERHEAVLSRDEDKYWNNDAHLKMEKVEFPYDIGLFANLAQGMGTRNVLAWFSPLAGGPTINPTGKGTGWEWEENGFNERVGMWPPIDPEKQRRAAKTWPGAAIKASAREYEMTPAETKAAFMKRQQADFRQRSGIMAELEEVEDDHQQFTEEEDDDDSAYEDQGVPLWTNSSDNTLWDFGVDEDLEEPPIPLQEEDEDDVPLAELIRRRRVLTKELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U865</accession>
    <name>A0AAE0U865_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U865"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042008643" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7877" checksum="FDECE511E3299307" modified="2024-05-29" version="1">MVIAHITAMSKSINCACLLLLNLLNIKSARDTRYSDVKHDGVAASHSNLSNSLTSLASIGMKQNCDDRTRMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U871</accession>
    <name>A0AAE0U871_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_388006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="62"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="366"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="639"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1710" mass="187005" checksum="78F0C4B1CF1F6735" modified="2024-05-29" version="1" fragment="single">QPLKQPFAGLLSRATNKSLLGESVRTTTNSSLSLSSLELSEYEKGPLGLTTLHESSSPVADVVFIHGLGGGSRKSWSYSPSPDHFWPLAWLPTDPDFTQVRIHTFGYKADWGERRQSILNIHDFAQSLLNALRNDPAIRRTSTRIILIGHSLGGNVAKKAYILARQDPAASGLAARVHSIFFLGTPHRGSDMAAILENMLAASGGRKPFVSDLRPNSAALEGINDAFRHYASDLNLWSFYETLPVRTARFVSRIVVERHSAVLGFPKEEIAAMDADHRHICKFSTPLDPNYKMLRNSLLTAVDMIKAAAASLSQSSSIINQNTVVARLMPGPASAAGVISRLRTFLAVHGSVEGNLETLQILREPGSCQWFTEKSCFASWVAGTAPGILWLMGRPAAGKSVLSTHVIEQLKETPGVLCSYFMFKTGESTLSDCFRSLAFQMALQDDQVRETLLCCENDGIVWDKTNDASVWCHLFVGTIFKLPSISHHCWILDGVDECGDFSAFFTKKFLIAIPEDLRLFATSRSLDEITRGLAAIGPNRVDVQLLSDADTLEDMRLFVNTRLTDLGRLDSVADREDMCEKIIKKSSGSFLWTRLVLQEFEDAWTREAMETILQSVSTNLHKLYSRMLRPIELDDRKMPLAKSILTIILLAARPLTVEELRCIVKLELNQTLQNAAKAIPDLCGQLVFVDQDNKVHVIHETVREFLLAENLGLGMAIIQSEGHTRLGSLLLKYLSSGVLKAQRLQLLQSSGRAKGFTKPISASQPSDLSLVGYASIFFSEHLHQAVLTDHDLMGNLCKFITAENIFSWIEHIAKGGELAHMTRSAVNSRRYLRGRLTQVSPADQSGQLVDGWISDLIHVAAKFSSQLLACPSSIHCLIPPLCPSSSVIGRSVSEGKRRSPISSPLVVKGLTPGTWDDCLARIDFPSSLTTAVSHGDHLFAIGLSSGDISIYHAVSFELLLGMAHPERVMILQFSLNDIRLASCGKKFIAIWDTRSSTMLHSFSLQSPPLAVSFYGANELLCASRSSELIKWTLDKGEHESISWKEDHYSYFSLHGITPTQPPSRVALLATAEDMIIAVGYRGLPVLIWNALESHVLGTCGADIEDNGIDAMVFNPNPETPLLVVSYQSGRLCVFDYITMELMFSEPSMCAASLACSLDGRTLVTGSNQGVMEVYDFESGKDGASVLMLIYRTNHSTDEISRGVSLSPDGLRFVDIRARQARVWAPAALETSMLDNVGHSEISTQLVASADGRFIIAGKDNGEVALFSTDDGNQVHVLAQHGRGTSIECVALGEPRNLIISADRSARVLVADLDMPLLEVAKTSDFQRARIILDSRFDGAVLRMLVNPKASRLLVIGLHDVELWEIPSEMGFSDKSPQGSSAEPLASPGVSWSIKRSEKFVSIFQHPSNPAWFVATSIDVARVYSWIDFAEVTPGEGIPLMRGVPVPEGINFDHQPLYYSWKTKPLYMCQVWQGFVVELFQMTAYSRPRVYVWPATTFDPHSNGTTSAVRQPAVESDLDAISQAVSAVLGMTGTSTLVFLDIDLWVCSVELQSVAAAAPPKAPNPQLITGFGSLVSSPSSSRQNSGPSLLQPETGHAKRHFFALSEWRTSGRLWCTLAQVPTLALENLGGRGVNRLGSSSPDVVFTDGTGGGIVVIKGGLDFSESVKANSSSTSSPPAASDIQSNRDTPGLRRNHVWNVVSGSMHRRSSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8T2</accession>
    <name>A0AAE0U8T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_461767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8T2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053136">
        <property type="entry name" value="UTP_pyrophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YGJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399:SF1">
        <property type="entry name" value="UTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="53170" checksum="2872987DB63BBCE7" modified="2024-05-29" version="1">MPIGIQRINEKKSQPNDRIVFIKPLKGPDEAIAQDFLERIAAQCLPIMRENHLSVMSLEEYEPNAEFVGRNFNAGEVIQLVLKARFTSHWLPFNYTTRLAHCKQMNHSKAFWAVRNQYAEQMRGLWLRKFTGEGLWGRGALLATGQWETNSVQPGEMLPEYLCGGTYRSRGRKRKAKKVLTYQEQKERRILKKFGANGVVLGDDAETKRKLEKGRTIAAKPRVAASARGRELRAAAALARFDQQKEEPDGEKRIKGEDDDEESGSGEDDYEDEELNSGQLDALDLDGKRMLDAKGRGMVKVCEDENLEDQDAKQELLELQNFSSQRSEPASRSKPPATSKGLKSEPSSLLHPDAPPRAPRQDQSVPREFKTIKSEPSTQSELTAPPLRTTQQAALKLPKREDHQPQEPKEPIPSSCPVCSFANDQLSATCAMCANVLYPGRIPDSWACNSRACQGTKYRNAGDCGVCGLCGGRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYQ9</accession>
    <name>A0AAE0JYQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_490359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYQ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042133360" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="30795" checksum="D62493879C02D451" modified="2024-05-29" version="1">MGFKVFKNSTVALVAFVCIQLATAHMTLSFPPPFRSSGQNKDYDMNAPLNPDGSNYPCKGHHSDLGTPAGKSTATFALGSAYSFTIAGGAPHGGGSCQASLSYDQGKTFTVIQSIIGGCPLSSSYPFSIPADAQTGEAIFAWTWFNRIGNREMYMNCAPVTIAATNNSKNKRAEVGPRASSFSSRPEILLANIDNGCHTVEGADVTYPNPGPDVVNNGGTQLGPAGTCGGTAAALASNSTSAAGSSSRPSAPALTAAALAPTTLQRVIQATTVNERAGGSKSGLSNVGNDLGNLCVNKGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0Q3</accession>
    <name>A0AAE0K0Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_489819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0Q3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3367819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="176" mass="18820" checksum="ED6C6E5484042532" modified="2024-05-29" version="1">MPMPRTQDPWPSNTQATAPPSPTAVDQTTPLLPRRRRNGSPTNPPQTQTRAEKMSTLFWKVGAISGAVAVAFGAFGAHGLKKRIADPAKIANWGTAAHYQLIHSVAILIAHNNPLAAGLFTAGSVFFSGSIYALTLDTERFRFLGPVTPLGGLLLIAGWLALAFSKGGPPPRWPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K176</accession>
    <name>A0AAE0K176_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_70067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K176"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="41820" checksum="C79B807B31AD182A" modified="2024-05-29" version="1">MKKTLLLCFIHGFKGGESTFGDNYAFTEHLRGLVAGALPKVEVKAIVYPKLMNKVIDLEVAAGTPSPTIDPSVRVILIGHSMGGIVAAETAITLASEKPIHGSTNPATDDDPKPSATTGAMPEPPPRPPTPSLLMFPYIQGVLAFDTPFLGISPGVVAHGAESKYATASTAISQIAGITGLWGGAKAAGSDASAMRNKPPPAPALPAAETNEKRGNGAAAAADNNNGWGKWGKIAMVAGAVGAVAASGAAAYINRDQITQGWSWATSHMEFIGCLARKEELRRRVAYMVRLNKELGVGFGNLYTQLGKAPSSKSTIAGTVVGNQRTFCVVPLREQAGDWRVAINDKMTDEVEAHMAMFEPKDNPAYDKLANNAKDMISGWLRNDWYESSSDAIGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1L9</accession>
    <name>A0AAE0K1L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B0H63DRAFT_86425</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1L9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAK3367805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118199" checksum="E904A881D0D485C1" modified="2024-05-29" version="1">MAKSGDPLVTHISGQSNRPLSRPAHALTHQQLAEEIGADTLTGLYKEEAKRRLDDYGRNELGEAEGVQPFKIVIAQIANAMTMVLILAMAVSFGIGSWIEGGVVAAVILLNVVVGFFQEYSAEMTMDSLRSLSSPTASVVRGGEAIVVPSGEIVPGDLVEVKMGDTIPADLRLIEAKNFETDEALLTGESLPVRKSENSTFDDTTGPGDRLNVVYSSSNVTKGRAKGIVFATGAFTEIGAIASALNKKDSRVRPVKRGPNGHAGPHRYLEAYTLTLGDVAGRFLGVSVGTPLQRKLSKLAMLLFGIAVVFALVVLGTNRFHTSQEVIIYAVATGLSMIPASLVVVLTITMAAGTKRMVERNVIVRNLKSLEALGAVTDICSDKTGTLTQGKMVARGAWVPGIGTYIVEHAGEPVNPTVGDIRFSPQMPNTISLASKSENTNSDTGTIVQPAQLLVDSKSRLQEFLAVASLANLATVYEKDSAWHARGDPTEIALQVFASRFGWNRLSFIGGESPKWSEVAEFPFDSDVKRMSVIMRHNEIGDHFTFTKGAVERVIGVCTRYCTGDAPGDEIDITEEFRDQILRNMEVFAGLGLRVLALASRKLDAGAKTSDDTNRDEIERGLIFRGLIGLYDPPRPESAAAVRECHQAGISVHMLTGDHPETAKAIAIEVGILPKRMERVSADVARAMVMTAGEFDALRDDEIDQLPVLPLVIARCAPSTKVRMIEALHRRGRFCAMTGDGVNDSPSLRRADVGIAMGMSGSDVAKDASDIVLTDDNFASIVAAIEEGRRIFDNVQKFVLHVLAENIAQAGTLLIGLAFKDHEKLSVFPLAPVEIIWIIMITSGLPDMGLGFERAVPDIMRRPPQSLKTGIFTPEFLIDMVVYGVWIAVLCLASFVLRVYGFDDGSLGINCNDAYSKECDTVFRARATTFACLTWFALFLAWELVDLRRSFFSVREQPAGSSAINYLKQWMADVFRNKFLFWSIVGGFVTLFPTIYIPVINRAVFKHTAITWEWGIVFIAAGLFFVGIETWKGAKRVYFRRVARTTTGRQWKDMDIEERVFGDYLSGGSGFESSSSTVGHVQVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K213</accession>
    <name>A0AAE0K213_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_79877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K213"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="39969" checksum="88459878222431F5" modified="2024-05-29" version="1">MDTDDQGPRILSTVWSLTGLSGLFLTVRIFCKLQTKRRLWWDDYVLALSWFMLLISVILVTISASLGLGKHFYAVPVENYSKLGLIGNFTGTFSILAAVWSKTSFAITMLRLMQGRMKAFIWFIIVTVNTAMGLNAVFMWTRCSPAAKTWNPYMDGTCWQPDVYPTFGMFAAGYSAATDFILALLPWKIIWGLQMKRKEKVGVALGMSMGIFAGATAVVKTIEIPTLSSSDFTYVSAPLILWGSAESSVTIMAASIPVLRTLFRDLQSLSRGLYVSGSRNENTNNNLNQTPRRVHARGATMVMISGGNGLPSPPLTTTLTNSSDKAPLRESAGRIMQSTEIMIAVERWRKGDSSDGKEMEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2I5</accession>
    <name>A0AAE0K2I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_488389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2I5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="339" mass="37629" checksum="FBC7F92A439D96BE" modified="2024-05-29" version="1">MAQTPLDDPSQRPAMHYEQCTANDGCPLAFQTSLPLTQGTLAAGPKYNTCILLMHGFSGSSEYFTRNFDALSKHYWVVAPDMRGHGRSGRTKGGYHVARLASDLNDLVTHLVFERPRVSPPAADDKPLTVVPVGCSIGAAVLWTYVEIFGSAAFQFSGFVFVDQAPVQDRSRFDGWDASKAHRGCYDEATLLAAQEAWISRPAETHLSLVAECLGYRHAPDNEDNVSSEQRARDEAFFTAISAQCDGTWLARLLADHTRYDHREALEEIAVPTLVMAGWRSGCFPFAGMREIIDRIKHSGKVDETRVTVSVYGSGHWLFYEQPEQFNRDVLEFVGRCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2T0</accession>
    <name>A0AAE0K2T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_515115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042240349" evidence="2">
        <location>
            <begin position="17"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="668" mass="74200" checksum="610E44B5ADDE9C85" modified="2024-05-29" version="1">MHHFVFAALGWAIVLATPLPAADGTQELNIEYQTSLSFEVDENAKGSVIINSKSSVVHHDLDVSGGINCTSMYSEVESRQPSAGMIIKSLTSNTVTWLTEDKYVPVLAGPPISTEISAKNVSRLRKRHAGIGSCGAYHMYTERVGDGDPHQNPLNVQLSGCEVRYQQLTSFTISWSASAEAYSCISAGFAVEQSVETGPVSIAMESPARGAKALTKPEHLVEEYTFASISLKCTEISIFADLFKDARRRALLRYLELDVEFPNSRDHGSREGFAREEFASHKAQLGIAVKSLFNLLSDWKTDYGDLKFSLLLSTEGDHLDFDRCGRLLHPIAIGRLIDQIPLLHSLTLVVKSPANKQRKMRKQHRKALAKSLTLPLLRPDGLRNLLYLKISNNDARTPEYHCYKRGNLQDNNGVDPLNDAIRKLGQQTPLQELTLQDTLHQKSGRNGLAIVGVAFLQRFYILAHIVAPSGEWYFTGDKAACKRKIRRICAVNWGDESPVEDSSTDDDKSDIPSEEGAEPDDHGWHDGEEDRVGPRLLWRDMPDSDTLGPLLVAMARGLGQDMPRLRHGTLYVRCESLSSYDPDYNVEVQCAAAGWPFALDLFQSENGLANPHQAVSSVRTCRISLGRSVHSWVVPDEMKSAWRDWLGDDGVLEIGTGRWKDFVPSMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2W0</accession>
    <name>A0AAE0K2W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_497821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2W0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="250" mass="28290" checksum="A5E4FF6E64BEB7A1" modified="2024-05-29" version="1">MRLINLGTLQLEEFFDRDVPPHCILSHTWGTEEVTLRAMGTMPIRGFCKIASQLGSTSLRYGWVDTCCIDKTSSAELSEAINSMFRWYSNAARCIVFLADVEIMPYKGDDRIVSEKLWADLQASRWLTRGWTLQELLAPRHVEFFDKNGGRIGDPDSLNFSISAATRISHDELHPDGWQKANIARKMSWAARRQTTRVGDIAYYLLSLFNAKMPPLYGEGERAFLRLQEEILKESNDLPILAPSAKGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K3G9</accession>
    <name>A0AAE0K3G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_489128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K3G9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="91" mass="10184" checksum="B0CD0A788D675600" modified="2024-05-29" version="1">MDFLSSSICLCCFQHDQQATGLQVNMLGVSVLSGIRFCMGGYMGWVNCKDGCFRKEKLGDKHRLWLSSLHSVCFIPLGFAVISMSLICHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5A8</accession>
    <name>A0AAE0K5A8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_551803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5A8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042103502" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22503" checksum="391AECAAA656BC71" modified="2024-05-29" version="1">MKFTTALALLPAAALANPLATRQVERAKFTGNFRSQGTGCPPGSVTVTFSGEGTFANEFATAFLSANTVQVGPGIPDSQREKDCSIFLEVRLPLNRCTRINYGSTLNGPFRLDPGVTGNLHRAYVLERATQVTGNNPPDLTFSSATPGPDFIQEDHPAGSYNIRNANEQNSSFSLQERMFLQKPNNSVSGSLTNDVWAVSITDQVQCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5P9</accession>
    <name>A0AAE0K5P9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_318345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5P9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="525" mass="56453" checksum="A4FAAFE2D2C871B7" modified="2024-05-29" version="1">MTASIEDDIGAGRHENGRPSRSSDRSPREDQPLLPAPEEASWKPPRGFLWIQVAIMSNVFLYGFDGTITAATYAVISSEFDAANTASWLTTSYLVTSTAFQPLYGRVSDIFGRRLCFFISTVTFAIGCLGCGIAQDVVSLNCMRALTGFGGGGLMTMATIVNSDMIPFRKRGMYQALQNGMFGFGAVCGASFGGSIADGIGWRWCFLLQVPISAFALLVGALVIKNPSGGFDLGRGVRDVWARVDFSGALLLVVAISIQLVGLSLGGNELPWSSPWVIGSLVGSFGLLGLFLLVEAKTTAIPVIPLRMLRGRLPVFTQLANICVGLSAYAVSQDRDVHMRSQLTSPQYLFNLPLLFQVVLLDSATTAGMRLAIPSLATPIGGLVAGVVMSRFGKLSGLVRTGALLMVFGNLLVTSIGFEDSTWKYFVYIFPANLGQGIVYPAILFTSLSTFEHADHAVSASTVYLIRSLGTVYGVAITSAIVQTTLSLRLPDALGDIPDKREVYHSCHRVRKKWREDAYEGLDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X2</accession>
    <name>A0AAE0K5X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_514703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF184">
        <property type="entry name" value="GTP-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="697" mass="78061" checksum="8E3F131511518AA6" modified="2024-05-29" version="1">MTTYEVNIINNYGSVHARNYCVYAEAPLIEGGGVQQRDILRIVSKVVGPIENGAHKTFSYTTRYFGFIGRRIPAGDGNDKGTVVKLEMEREVDLGDNRDNATCLLAHVSKDGGLGLAISTQEHSAEGSFKIRCMDPKDAPHDVVIGLAYQSSHALSPLVPVAAVPYAYDVDYKITPRGSSIYIVRDDMVLGQVIPTTTLSSGLHVVFRGSQTEARIAENSVGQFSVDMTGFGTTPETPRNPNNDNPSSPSNPPKKEEDRQAQEKESQKQTAAAAAAPIAIIVMGITGAGKSTFLKEVTGQDVPVSDGIDSATTEVHPYTAIVDNQKIMFLDTPGFDDSAQGEAEILGKITTALAQLYSDSVPTKGVIYVHDITGERLTGKARRYLEMFKKIVGENAVRNVTLLMSKWDRNTAAFRARKESDLKNGPWKLLIEGGASVRKIGADEGHEAYLALVREMLANVSTKLKIQEELVDEKLPLNKTGAGQMVDERIREETEAIRAELETLRADRAKERAELANELADWQRKGDLLEAKFGESKLKGDQMALELQRAREELQALRRQQDEQRRLDEQRRLDEKRRLDEQRRLDEQRRLDEQRRLDEDRRRQQQEEEEYGRRQRQIEEQQRQQRESRTAEYNALIERAGNAFEDCYMAEALQLFSQAYAIAVAEFGPGDPRTNETQRNINIIRTEYLGSSIDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K684</accession>
    <name>A0AAE0K684_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_564715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K684"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="15476" checksum="17CC58AAB09EE2A6" modified="2024-05-29" version="1">MATFRKPQRNCALPVLLGNRKIRNKLRIWDKSKNYLDKPPKDASYIYAALYKAGGLDNDVNAVALFLLTCPHVGWVITLLAPCFGGALTDTATDVLFQECVLALLALPSASQFLSIVVVGNHQRVSRADTIMGLEALTTGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6C3</accession>
    <name>A0AAE0K6C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_317164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6C3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="18077" checksum="8F7BDACAC7B8F30D" modified="2024-05-29" version="1">MACHGYRPHAPYRLQVVKATRHVSRNLLPLVKQFWIYKRLERASGHGISFKSLVIFSSASAIFAFATLYAFVALYTHDMYKAMAMVMPDLRREKVKPSLFNSTNTDRQYLRYRLPGDWCLGRCGHSAGPYYPRSRNRSTSRSGILICLGDEVGANDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6V6</accession>
    <name>A0AAE0K6V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_564584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041967345" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="162" mass="16795" checksum="F584F7AB796A4737" modified="2024-05-29" version="1">MLSAALLALATVLGTAVVGPAIGFFRPMECNQGESAKRLCYTAPENTPQDVSLADVKYAANYLRSYGRQTKASRLFTMKIVETPGCGEWSLYTRGSVLITAKHVGMAFNSSQQAAALLGCATDGGSLGTIVNATNPAYTPAAYKALNAVSSGLVIKVVAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9E5</accession>
    <name>A0AAE0K9E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_513909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="542"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="763"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2212" mass="250062" checksum="E7E2FFE522E1BCF0" modified="2024-05-29" version="1">MTDHHRDVSQYKYSAMSNLVLQADRRFVTRRTDEATGDPESLAGRLSINDMGSRVARESAPKPKKTSAMPDVERGSLREGAEILDRMRGRPDTVARGGGILSGAEAAIEGIRYRPRTQPTRNAFNLILTIAAEHLGDVSHEIVRSAADAVLEYLKDDDLKDYDKKKEIDDILGESTTPKQFNELVNLGKKITDYDAQDDDDEDVADANEDGEDEIDGRQGVAVNFENDEDDDGMVDVVREESSEDEGEGDEEDRPDLAEVAEGGEAGQDRDEEQVGLVDGDAMVIDSAADTKSKAQEKNQIPARDIDAFWLQRQIGKVYPDAHTQHDKTLSALKTLSGEPDEPGGEEKQLRDIENDLMELFDYEHNEIVQKLIKNREKVVWLTRLAKAENTEERGTIEREMVSEGLRWILDELHGKTKDEQKKPKMEIKMDIDSSAFANGELQKPARPEGQLVGGLKPKKLINLENLIFDQGNHLLTNPKFRAPEGTTKRTFKGYEEVHVPPPKKRNDPSDASIPISDMPEWAQIPFSTAKSLNKIQSKCYPTAFEDDGNMLICAPTGSGKTNVAMLTILREIGKNRNANGDIDLDAFKIVYIAPLKALVQEQVGNFGKRLEPFGIKVSELTGDRQLTKQQISETQIIVTTPEKWDVITRKATDISYTNLVRLIIIDEIHLLHDDRGPVLESIVARTIRRTEQTGEPVRLVGLSATLPNYRDVASFLRVDPKHGLFHFDGSFRPCPLRQEFIGVSDKKAIKQLKIMNDVCYTKVMEHVGTNRNQMLIFVHSRKETAKTAKYIRDKALEEEQMDMILKRDAGTREVLSETANGVNNADLKDILPYGFGIHHAGMSRADRTDVEDLFAAGHIQVLVCTATLAWGVNLPAHTVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQFDTYGEGIIITTQTEMLFYLSLLNQQLPIESQLVSKLVDNLNAEVVLGNVRTRDEGVEWLGYTYLFVRMLRSPGLYSVGAEYEDDEALEQKRVDLIHSAATVLKKSGLVKYDEKTAKLQSTELGRIASHYYITHGSMDTYNKLIQPSINDVELFRVFAQSAEFKYIPVRQEEKLELAKLLAKVPIPVKESIEEATAKINVLLQAYISRLRLDGLALMADMVYVTQSAGRILRAIFEITIKKGWASVAKLALNLCKMAEKRMWPTMSPLRQFPNCPVEIIRKAERIEVPFSSYLDLDPPRMGEMLGLPKAGKTVCALVAKFPRVEIHAQVQPMTRSMLRVELTITPNFEWDDEIHGLAESFWIIVEDCDGEDILFHDQFILRKDYAGSEANEHIVEFTVPITEPMPPNCFISVISDRWMHSETRLAVSFNKLILPERFQPHTELLDLQPLPVAALKAKDFAALYPNWQQFNKVQTQTFNSLYNTDNNVLVAAATGSGKTVCAEFAILRHWAKPDSGRAVYIAPFQELVDIRFDEWQKRLAPLRGRKDIVKLTGETTSDLKLLEQGDLILATPTQWDVLSRQWKRRKNVQTVELFIADELHMLGGQMGYIYEIIVSRMHYIRTQTEFPMRIVGLSVSLANARDIGEWIDAKKHDIYNFSPHVRPVPLELHIQSYTIPHFPSLMLAMAKPTYLAVTQMSADQPALIFVPSRKQTRATARDLLTACLADDDEDRFLNVNVDQIRKLLDRVQEEALAEALSHGVGYYHEALTLSDKRIVKHLYNNGAIQVLIASRDVCWELDVTAHLVIVMGTQYFEGREHRYVDYPLSEVLQMSGKAAQSSRDGRSRGVLMVPAVKREYYKKFLNEALPVESHLHNFLHDAFVTEISTKMIESGEDAINWATFTYFYRRLLANPSYYSLTDPTHEGLSQYLSDMVETTLKELAESKIIDFDDEDGAVTPQNAAMIAAYYNISYITMQTFLLSLTQKTKLKGILEIVTSATEFESIQIRRHEETILRRIYDSVPVKMAEPVYDSPHFKAFVLLQAHFSRMNLPIDLSKDQEIILTKVLSLLSATVDILSSDGHLNAMNAMEMSQMVVQAMWDRDSPLKQIPYFTPEVVKVANKFGIKDIFDFMEQMNPDENPNYGQLVKELGLSQAQLAQAANFTNSKYPDISLDFEVEDAENLRAGEPSYLKINIEREVEEDEEFDPTVNAPFYPGKKTENWWLVVGEESTRTLLAIKRVTVGRNLNLRLEYTVPTPGKHDLKLFLMSDSYVGVDQEPTFSVNVAEGMEVDDDSEEEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9H1</accession>
    <name>A0AAE0K9H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_401828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9H1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="30826" checksum="B28C32E24980B768" modified="2024-05-29" version="1">MEQNVDTELLKAERLFSVEGWVCLVTGGGTGIGLMCAQALAANGARVYITGRRKHVLDSAATAHSPSGGPGQIIPIGPCDVTSKSDLDALCTELSTKRGESHLNVLVCNAGISGPKAHPDTSDAIALRAKLWEKEDPASWADVFNTNVSSVYFTTVGFLPMLQAAARQTRQSMAGNVIVISSMSGIMSGAQGHFSYNAAKGGAVHLTRLMAIEFEKTGIRVNSIAPGCFPSEMTTGESDARGKSNLPDEMVQKKRHPVPAARAGSDEEMAQACLFLAKNRYVSGEIVAVDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9K8</accession>
    <name>A0AAE0K9K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9K8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="604" mass="65468" checksum="68F2BFC96F861BDC" modified="2024-05-29" version="1">MIASLSCQNVQTLISQYFPDFHSSSIFLDLNFKSITMPPPTPFEVAVTGTQRVQPFTPPRTKQITPLSLLDATTANFALTNAIWLFPSSSSPVSGLVDHLAQSLRQTLNAYPHFCGQCHSIASLDGGATDPETKAILPPHAQRFGRIYAHYGTTADPGVEFTVATCASTLDEIYPSTRTKTKPVWHGAELLKAFSPTSAIANTLDPPSPADDRDITKIQPLLAIQLTELACGGFILAAKAAHPIADIASLAHFVKNWAFISRSTLLAGCQTSHELQQDPGPVPEPVFDPSLLDNLAAGDINSPLPDSDILPRAKEMPFHRYDWWAASKNAPSWATAVPSAFQNQALEPAGDVMPWDEWDMKAPVASCIIHLTHSQIEYLYQKAAGGEGEEEKGASPRLSKHDAVLAHIWSCIVRARQLSSSTEPVHCDLVLGLRPALHLPESFIGSPTLMMKIELPASKIADGDLELVGRRIRETITAASSKPGLRAHLHGVAYEKSPQRIWQGFLGRKHIMVTTWARAGIYAVDFGLGAGSEAKYADGVVPPMDGCVLIKEAPPLGTEAGSEEREVGGRRVGWTDNGVDVSVHLRAEDMERLVKDPLFLPECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9M4</accession>
    <name>A0AAE0K9M4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_485382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9M4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="119" mass="13112" checksum="870C24BAB3A0E7ED" modified="2024-05-29" version="1">MVVKIRLARFGRLNKPFYNIVVAQARTARNSRPLEVIGTYDPVPKPDSYDASGKLHKDIKLDITRARYWVGVGAQPTDTVWRLLSMVGILEPKHQPHRTPAQQQSTTPPAAAPASTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAA5</accession>
    <name>A0AAE0KAA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_300864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAA5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="237" mass="25179" checksum="61F4AE325818ABD8" modified="2024-05-29" version="1">MAAAQEKITVYNAADLKNTSDDAIPNYLNSLKFKQSHRLTDVRLAMGYSAFTIAGACFLWDYKLGFESTKWLTAAAVAIYTLLNGALTLWIMMVEKGTVYEGTAPSGETLRITTATKKQAAKGQAPQYHVTVQVTPKGGNGSSKKLEISRPFAEWFDGTGAFVAAPFQSMLASAVPVIGKLDPKRAAAPAEIEGASIASSYTPELLDALAKDFGSNTEAATGVETASAKKGGKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAH9</accession>
    <name>A0AAE0KAH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase oxdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_496882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAH9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041978405" evidence="4">
        <location>
            <begin position="16"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="260"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="45248" checksum="38BC5F9743A83CF1" modified="2024-05-29" version="1">MKASLQLSITVLVQALFGTALPAVVEKRADSGPQFLKGQPIDGAGKGAPILGGTNKQIDLQNPDNLGQQSTDNGLVPNLKWAFSDSKTRLLKGGWVREQVITDLPSSHDIAAAQQHLTKGAIRELHWHRVAEWGFVYNGSVLISAVDEDGKYQVEKLNYGDIWYFPKGAAHTVQGLDDENEFLLVFDEADFDKVGTTFNVDDWIAHTPKDILAKNFGVNASVFKDVPSPNPYILNATVSTKNVTGGPAGTLSGNASFVYRTFDHPSESVPGQGGEFYKIDSTNFPASKTIAATFVRLEPKGLREMHWHPNAEEWLYFHSGTGRATVFIGGTNARTFDFSAGDTAAFPDNSGHYIENTSDTEDLVWIEIYKSDRVADIPLTQWLALTPSDIVAQTLKIPLSVAESLKKEKQVLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAL9</accession>
    <name>A0AAE0KAL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_564096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAL9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="9">
        <location>
            <begin position="556"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="740"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3372730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1164" mass="129290" checksum="65A311CA45709772" modified="2024-05-29" version="1">MTSQLFFLVGDSPSTARPVPVNVEGKFDDLRRAVALVLHVAVPQGLSFHKTEADTDKLESVQDVWSAAGPVAVRVDGLAVQDPQGPPGLPVVGSFYEIFPDHLGNHYRLFRKYGHVIKTVNMGKTNYLSDSPEVALVALSESAYFTKKISENHPLWGIKDNTAIFIGDTETENWRLAHKFIPPSMGPKAVRHYTPLMQECVRSSFPIFDELDSRGEAWNVYQFMVKLASQTIGKFAFGKNLGHFDSVEAPAHPLITNIVNMLSLNKKVTARGEWYRSLPWGDSAKLKAVQKTVYAQMKEAVDDAPSSGIANLPFGEAATRASCVADYLVNAVDETGSRFPEGLVLSNMIVITGAGYTTTSALMSWLVYCIVTYPDCQDKLLQELIDYGISPSTQWTPELAHGLPYMDKFVKETQRLHNASFQPGRTTKTEVILPGGYRLPANATVIPALYAVHTNPEHWHDPFRFDPERWDTNEVKNDRHRAAYIPFATGARGCIGFNFALLEVKVLLSELVYRYKFAREGLEAVEYDPEFQLIRPLNFIVSKMTWTPSTTGSRPVAVLGAGVLGRRIACCFVSGGYNVHIRDPSAEARRAAVQYIDENKEAYTKHLPATTLTKDHKFGSYVASELIDTAVKEAWLVIEAVPEKIELKIDTMAELDHKAPADCIFGSNSSSFKSRFMLDKVTSPERRKRICNVHFTMPPKIRTVELMTDGETEPGVFPFLTEVLERCGMLPATAQKESTGFIFNRLWAAVKREIMFILAEEVSTPAEIDKLWRHMFQAEIAPCRLMDQIGLDTVAFIEDNYIQERHLNGAQTVDFLRANYLAKGKLGLKSDKGGLYPSASAIPSPPLTIVGERTRANSPDHSQDHKEEPALYFLDVGFGGNCKSFSDVSTNGKILRRDPSTGLISTIVSSQPAPDGIDILGDRIFWTNMGRDVNARDGSVMSSKLDGSDIQTLIPEGLVTTPKQMVAVASQKKLYFCDREGMGLHRVSLDGKEHEVLIQRTSEARDLTKWCVGITVDVHNKKVYWTQKGASKSNQGRIFRAGMEIPPGQTAETRSDIELVFGDLPEPIDLEIEQETGMLYWTDRGEHPRGSSLNRGFVDGKKEEIEVLARHFHEPIGLKLDAERRQVFVTDLGGSVYSVDMDNGAKTVLHSDDGCYTGIATVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDK5</accession>
    <name>A0AAE0KDK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_256068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDK5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041962579" evidence="2">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="505" mass="48234" checksum="7EFB5BFD4ABE04AE" modified="2024-05-29" version="1">MTKASVLLYLVAYFAAIGSGAPLPKDVATVSVTVTASSTDKDALSAPEPAPGSAPVPVPVPVAGSALKAAGEPGPESAPASSAPAALASEVVPEPASSAADSGIGAPVPSSTAGEASALPSTASDSLFTTVTVSTTVTVDPPSSTAVPVPQDASVEPTAPAEAPTSSASEDPAATPVSSGGPGSETPSAIETPSAASSGSEGPSPSATESAAVPPESSASEAPSASATESAAVPSESSGSGSPSPLATESGATPSESSGSETPSPSSTAEPTPVPSEPSTSDGPSPSATESAATPSSDSGTPFPSATESAAGPSESSGSDAPSPSATESTPAPSESSGSDTPSPSATESTPAPSESSGSGTPSPSESSSPDTPSPSATPDSALAPSDSPSPDAPSPSELAPPSDPETEPTPASSPTPETGNSETDSSDSGAAPKTSEDGDKESAIEQRMINIQGQSGSNSNYQQQGKNNNPLCTCKRASAAHRRANNNQGQANNQGSNGNGCKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE64</accession>
    <name>A0AAE0KE64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_452403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE64"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042234726" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22053" checksum="8DC9FB9970771276" modified="2024-05-29" version="1">MKSTAVLAIASLMAGNAMAATGVLFTGQGCNVGTQLGVCYGISEGACCNSLSYAASARVWNDGSYTSFAWYNINGRCGQEADRGSGSACLETGFRDIFGVYYRTGASRRRDTRVNGTSIVSPAAEACESQQLADVYWLKFPNEKESTPYSASVVDVLHGAAAIDWKTQTFKVESVKTVRDILGAHGDGLTDEMKVQNADLLAKLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEJ4</accession>
    <name>A0AAE0KEJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7689 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_252940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEJ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056106">
        <property type="entry name" value="DUF7689"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24738">
        <property type="entry name" value="DUF7689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7689" evidence="2">
        <location>
            <begin position="64"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="481" mass="51629" checksum="A57599FFBD15B54B" modified="2024-05-29" version="1">MSIPRPSSRAGRPPSMPVPTPAVTALRDPTAGERAQNETGVDRFRHLATRGSFKCWDWRILPGATDKSFNCFAWSLGFTDRWVEGGSRAQMNRLYHHYMFVDCSTTPNEAEVELYDIPTAPAQLSRTIPASARNPQPRTISWANPRAVVLHAHRRDNPALDAPPGWGCSSKLAKEALIIHNRHALEDDIAWPGGNPAIRYGIIYQQWKRDPTRHPSFPGNEANDYPEAGHYPDDPVFEGGPGEFPAGHPGDTNGLNLSSGSGSNGASGSGTITGNQAGKTTTLASRTVTSSTRSSNGSSNSSSGSSTHSRSSSQTSVTSTASSKDKGKGKAATPSPFRAYSGKSYALANMPSYGKIPAPTTAAVKLAKAGYDATIKSQPTFEAAWAAWIKNWNATKSSNAAAATSIEGFEALRALGPKIVPLVVYKLASDPTAFVGTFLYNALETNKDYMVHPKDLLNYCVLQRQANLIVEMNGLRPAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KIV0</accession>
    <name>A0AAE0KIV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_220622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KIV0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47134" checksum="99BCD43AAF02C83B" modified="2024-05-29" version="1">MMSRPTRQGPLSPPPSPLLLSSPALGQPLPQLGFHVGIETELFLERRIPRSLTKDKAPETLPDFSIDLRDRYMQALRSKAGYPGLRSEFVEEQIEADPLFSKWCVINEISLTKREQEPWGLEIVSPKLPVSPSSHWREHVNALWAFLDQNYSITGDDTCGTHIHISVDGDYDLSMMKAIASAVIYFEPAIEALLPETRRGNHHTMSNWIDNPSLGHLGMSRAAAIQRIKSCKTHEEVIYIVSPGKPYGWNFKAWSRLKTIEFRRGAPSQSADDVFMWADFVMAFVKAALSKPLDYNRGGGVPYAPTIGGLFDFFADVAIPDGQFGGEVYGNSQSITRMFGGRQFLAPDFWLEPIPYAGEGLAELFEQEMHMNMWNAIDADDEAMPERILRARQMAEAKGARMMMLKEVEAMPRSRVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK42</accession>
    <name>A0AAE0KK42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="614" mass="64684" checksum="12B9922E89869C27" modified="2024-05-29" version="1">MDGEDDAKPDRDAAARSSASPPLVSLHPPQEQEQHSRSSYALLPPPSRSSRTSKSPPPPKSASHLAPDRLAKSRRGSLPVSFPPLFFQPNASSTSLAPSTAEGKPIPLDDTTTAHRTSALQKLNSTYPSAVRRHRYTKSSGAQSSTYSQPVLVRTYSGPSTSQASHSSAQPPRYRPSSGSRSVSRRVPLPSSSTSAAGFSGRPAQPSLGGVGSSNSSSGQRSGNNGSSFDRVAMPRHKATKASSKLSLPLPLPLPWQWQSASSQPEPDEPKLPPLEAFSFKSFMADIQAQGGDNDIGSDLDRIAEICARSRYSLSNQYEVHVAPHGSGLSFTSGGAPVPRKKGHSHSYSHSRGGPTLQAITSDDDDSNSRSHRKRRSGARRRSVAYGTLETIMSSSRSSEEDKTKKKPAAELAEEVRGRAAKKAWGNSTGSGSGSGSGSTANAKAGSRGTTTEDSQDPGQSSKAKLARKKSALFATAIMDSGRSTISHHTSSSVRRPAAALVSDLAMPQTSTTNLGVRTTPEAVADSGFSRPGPSRSTQAVERLEVHFADEPPHQGGPRSSTGSLLGWSTWVPWGKGDTGAAGHSRDTPSYAEGSLRQLLRSADATVDKGKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKA3</accession>
    <name>A0AAE0KKA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKA3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18652" checksum="CBAC3256618158BF" modified="2024-05-29" version="1">MTLTLLDDKQSSYDRFNISISLKPNHQSQSIHPSIIMTRSHKYNDKDHAGIAEGSVLPQENIPKFFAKNGFADVDPKKTKKNGGGKGNWGNAGEEVIDEPFNFVNARRRSNSSSFSTHPEQLKTKFEFNEPEPVFEESLHGPGEEDEHQTEGSSSTASDEDKVVKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKM1</accession>
    <name>A0AAE0KKM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_221419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3377630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="21187" checksum="619087A38DE7066C" modified="2024-05-29" version="1">MSRRPPRGEYIETDTGNKVARKATLVGTQNIMLGGKTVIQPEVMIRGDLVRSVQSSSSASSSTGAPANNTAVSIGRYCFLSRGCCLRPSGRLYKGAFTYMPLRMGDHVFVGAGSVVQAASIGNHVHIGAKVVVGELAIIKDYVRVLDGSVIAPNMVIPSFSIVAGQPARVIGEVPEGGHEDFELREMYKTVGNNVNPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLD5</accession>
    <name>A0AAE0KLD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_548347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="121"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="729" mass="81681" checksum="8DEFD849B87AFF7F" modified="2024-05-29" version="1">MLCGLEYTYKLLEFIKDEIRLIKLLPGSWDDDISFTMFHCRLKPPAPGPPTKRLPIKGLQNTLPPGWTVGEAMSGRYIFINQQNNPDVPTNSWHHPDASFDRSLYELPDQQLPQTTYEPSYEALSYVWGSPSNGVLTGHVVVDGTTPTTQVHLGANLAMALKNLRLPDRARTIWVDAICINQRDREEANREIRRMKRIFSLARRTIIWLGEEAHDSGHALSALASLGGQVEIYGNGFITTAPPGAHRTGYLPAYGERTRESLRGLLRRSWFSRVWVLQEALLANRWAVVQCGGHNDTAEWAVVRKALFVLTRREEVPLDVRKLVSPYRNALITTSHRSLPVLLNWAKYRRCTDPRDKIYGVLGLVSDAIADSVNVDYGLSVADVYKSAFLAYLKVTKSLYLLRYCHIGEKRTDGPSWVPNWENGDEKGSNTASLELLSMDLAAGYSSAVQTECLESDSVLQVMGRQCATISFVGAMASGSPDDVLQTMRQWEPQDLETMTNTEYLTGGTLLDAFLLTIFRGGTRERLPEYDGFLSMKDLRRAYLDARATPSSKEALLGYIARHSTADNLASMTTQEGYFCIAPPGAEAGDRVCVLLGCSLPLLLRPVRGTNCDFQVVGPCYIHGFMDGEALLGAFPSPSWRMEIWRGSAATYTSCFFDSSTGDRTPEDPRLPPLPEEWDEVTRARIQDDLPMFRTFRNNVSGERMDSDPRMLPESLAERGVQLDRFRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLJ0</accession>
    <name>A0AAE0KLJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_479019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="13">
        <location>
            <begin position="346"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="624"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3378155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="879" mass="97220" checksum="FB0FF2F3218FD76A" modified="2024-05-29" version="1">MEAQQQLRWRRPKILFLDAYDSFSNNITALLTTLLDVDVFVLPIDEVLPRLDGDDTSNDSEAFRRELSHYAAVVCGPGPGSPGNDADVGLMSRVWGLADGDLLPVLGICLGFQSLVASCGGQVRRLQRGLHGMVREIVHRQQPWRLKDSSEEKTKTTQDGEDIFCGVGAFKATLYHSLCGDIGQDTVPDTKWAEARWQPSLACPDLLPLAWVEEDRGGGGKPERILMAVKHRTRPFWGLQYHPESVCTESEGNQVILNWFRKALQWNEEHGRGATVDGSVEGGANHSARNATKPSLLSTSWLPPPRSENWWESLEVDPVLHSVTVPLPRGMQVPEVVELVDPEGSERIILDSANATASASARPDVRGRYSIIATGLEEALRIEYHTGDNYATAKLKSLGGLPADLVQRVPLGSHGSIWGLIAVFHEARHLEATELAEVPFIGGFMGYITYEQGLSDIGIQANPLRQHRRPDVCLVWVTKSLVIDHLAGLIHIQKLNAHGTDIDSWVDKTESRLLSSQPSQGRLRDCILPRKDAQQSATYRPLKTRRPSRSTTFQTPMTKEYERKVELCQELIAAGESYELCLTDQTRITRPRSDSDGERLAASGDTGIQQRKRRRSSLLALPQGSWQLFKTLRTRQPAPFASYIRLGAATLVSASPERFLQYDREGRCSMRPMKGTVRKSEAAATLCQAERILHVPKEEAENLMIVDLVRHDLHSICGAGNVSVPHLLKVEEYQSVFQMITVVEGQLPAAGKEAKARYTGLDVLAASLPPGSMTGAPKKRSCELLQQIEQHQERSLYSGVVGYMCASGRGDWSVTIRSLFRWDDEDHFVVPAEGGEPERQEVWHIGAGGAVTILSTPEGEREEMFTKLAGPLCVFAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2B0</accession>
    <name>A0AAE0N2B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_83425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2B0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="214" mass="23773" checksum="531A8B36A753CFEF" modified="2024-05-29" version="1">MPTFSWSSRQVASANYRTKTSSKIIPANPHPYSIKMCQALDYLVNKNIVHRDVKPENILYTPLPNGTYKYQLADFGLAHKDDTDGGCAGTSIYMAPEILKYRGKKQTTKADVWPLFITVAFVLDINNFRLKVQKSPLNILAAREAASLPEFVDIKDMAIEEPENRVSAGTCWTGSMAGNGRTTRRGRLARRITSSMDLDPPQVVAAQPPPSPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N363</accession>
    <name>A0AAE0N363_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N363"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="80894" checksum="53728DD9B91826AB" modified="2024-05-29" version="1">MSPDQTPDWSKAPEWEDLSAHTQWAAQLIRKVIADIENKASQDVLSTVKADEKHQLPVRGTLQQKGADGSVVDEIQEFKIGIIGAGAAGLFTAMILDHLNEKYQLNAKYEILEANTDDRLGGRLFTYYFKDKEGKSLGGHQYYDVGAMRFPHVSVMNRTFQLFEEVGIKEPVDCDNPKPGDLIRYYFTGTNTPTLYNGVQTNAPSKDFTANTFKITGLRPDIAAAHPDDLIEKKIRFWKKLYRFDPEMFWDGLTSEVDMLSVRQFLTNKGYDYDTIEYLETVETGNRWYDQAVSEMILESIDFDSDKPWSCIEGGTQEIAKRMLAKLNPGSFLNDNAPVLYKKPVKAISYVAQDDRKRVQVVVGGEEETPRTYHAVFNSAPLGAMQHMQLEGLNLGWEVKRAIRNLGYGASCKVGIRFKRLWWLEEPFNITEGGVGKTDLPIRNCVYPSYNIRDEKDKPGVLLASYTWSQEADRIGALIARSKSGAAADGSAPSADAIDAELQLKELLLHDLCRLHLPTRDCHQPDPDYEYRQMHKFLLDQYLDHFAWDWSADPYTVGAFAYFGPGQFQNMYPGLTKTDGKHIIIGEAASAHHAWVVGALESAVRGVYQFLFKHSKRSAAAARATEGYNCGKVRAPFGPLPSEYDRTSEVDLPDDVCGDRKLGEAKENKEHPPRGEWARAQVVFESARLRQGGDVLKPELLTEDDVLAIKQPLDRLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3B3</accession>
    <name>A0AAE0N3B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_515612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="32017" checksum="5DCE5749BF1FF5F3" modified="2024-05-29" version="1">MSPNFEASSLFSVKGMVAVVTGGGTGIGLTMAQALASNGAQKVYILGRRLEVLKTAAASSNPSILVPIQCDVTSKDSLQAAVDQITRETGFVNLLVANSGVLGSPNSYGKPGTVANVSELRKALFEEHSMEQFTDALHVNVTGAFFTMTAFLELLDAGNKNALKGGFGAPLNEEHAKAGAPGIQSQVIVTSSIAAYSKSPMSTPSYASSKAAVMHLTKTAAGNLARFGIRANALAPGLFPSELAGGMIGSRTPETESVDDPRYIPVRRFGTEEEMAGTLLYLASRAGAYCNGSAIVMDGGRLAVMPASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4N5</accession>
    <name>A0AAE0N4N5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_402487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4N5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46729" checksum="D5B7F3A437591DFC" modified="2024-05-29" version="1">MATIARQPFAPLDGARLQTLTSLKNRQNAISTPPIKRKASEVLDADDFENVDPSVFSKRSKGAGADSTFSKEFFKPSSFVLTKAASTPTLPAAKDVLSCAPGRIASARPRSVLQPKSPAARLNTSIAASSSMTAPAGRSPTRGSKRIGILSRRRTQRVDPPSFRLGSAAPFSLDAALKGTIPSYSGSVRSSNAELAPQAEMKSSWFFEIHEDTPEQEMTNLLQHSTCTLDISSDEESEQRARRENAEGRDKENIPPADDVSQTNSARAARAAAAASGFDDMVIEKQRGPLVEMNVADYYAEGCDGTSVIYVHDDEEAETVVDESEQPPLIAEAKAEAEAQERQEREKEEHRLFVEDTFEFAPRVELADVETVSVDLIMGKDDPSAKAAVLEPIEGTGESFELWESGSFRDEASVPASPAPVTTEEVPEIFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4Y3</accession>
    <name>A0AAE0N4Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_315916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="566" mass="61813" checksum="F30B5BE9A02B3DAD" modified="2024-05-29" version="1">MVTIAALLGTSVTQSGFATVPDPPTFLANNPDLAKALWSSGFMWTFFPTLYMTCYGMLWDSVVESLTQQQPYICMGTVAPPATASAATAGDSSTNDQERHRRQHQQDRAEKERQLGLKLDYASHNSWTSWWLAFRNHHFVLGTCMVLSLVWSVAGVPMTSFLFTDANVIFNTTEPVQLTKQFNGLAFSVETDMRQILEVVSAADIYGGSHPAWTTAEYAFPPFYPLNDNNDDDDSNNNMTIYTLGYSGLLDCHTYYTNLTVPLNETANRYDFPPIDDRNCPIAPDSLRAGSADSSYTLFVTTWATTSCGSGPASAEKNSRISLLAGSYPIPSASTTGHGRQLTNVTLISCIPSYWTTPGDLTVTFGLSSDDPNFIVVNNFQLAADDDASVSASSPASFETWQLFETALHLTTGFSPSDAVDAGLFGQLVYALYKRVVQQQQKQPPESNLELGLGADVLTYAMSRLFSSVFAVTAAHVLFQDRPSGAVALSEATRSTAKTRLVVVLQVAGAVLGILFVMLVIAVVLLVWYAEKPSILREEPVGLLGYDDVLKSDEVREIIKARERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5Y2</accession>
    <name>A0AAE0N5Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_563440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5Y2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3371921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="96" mass="10867" checksum="65080DC44605793A" modified="2024-05-29" version="1">MPPEELLNSVHASLDSEYCINKHIIPPLERILNLVGVNVRAWYDEMARRPSGSRSFKAMHTLAHVLAMAEIYANAKGIPIKDIPDWSLYEKLNPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6E6</accession>
    <name>A0AAE0N6E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_527272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6E6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="14847" checksum="8C0F053E56115299" modified="2024-05-29" version="1">MAGITADAPKGLGRESFSSMYGAGLRPNMKAEPNFASLNFRNHRQYVECNHFRWIAHAWCDDYKTNGKAAKCQPVIDKFEDKEAKCGDYKNIGTPIPFPVHPKQGKGVPKATCMASGATGEAAVTAQASSSPTRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6J1</accession>
    <name>A0AAE0N6J1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_401434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="260" mass="29045" checksum="C9FB39422888B31C" modified="2024-05-29" version="1">MAQVPVQTIHRDPQLFYWILFPITAVMILTGVLRHYATVLMASAAKKLDQKTMREQRSLLHGINVRGNSHALSKRSFTARRDALITAYESGAYLKDPERRGQAPPNPMSDPSSMEGMMGMMKNQMAMIIPNTLIMSWINAFFSGYVIMKLPFPLTIKFKSMLQAGVATKDMDPRWMSSISWYFLCIFGLQPVFNFLLGSDNAASQMAQQMGGMAPNAGQMFGPGVDPDKQFLAEAENLAVIEHYSVLDGVEQRLLEGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9W3</accession>
    <name>A0AAE0N9W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_549099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9W3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042015867" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="16993" checksum="A00DB9359EF11FBD" modified="2024-05-29" version="1">MIATVIAPFAMFLAGCLACPHPLTDSPSAHHMAHAHAHAHMHHVDWNNNNVTAAVKRAAAGQYDGDITYYDVGLGACGHDDSGKGSITNIVAVSAALMGSGSDSDLCNRKVHIKGDNGNEVVATVRDKCPSCPEGGLDVSEKVFKEVVGSLGVGRAKVTWTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBK7</accession>
    <name>A0AAE0NBK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRO41 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_495443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="15376" checksum="02547AB3A30DDB3C" modified="2024-05-29" version="1">MGRLTMSHWARLVTMSAAGYHILAAIQGFSWPKIFWDFSIKALDPLVRPVPVLQTVNLLAGLAMLALELPLRLVAGSSIHRSIGFRLAVLPLVALPGILLYHATNAVAYYSVAEVIYFSAYKRREVITPEPWTDISITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBL4</accession>
    <name>A0AAE0NBL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_477243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBL4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286636" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="42"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="438" mass="46652" checksum="FE85139643093149" modified="2024-05-29" version="1">MRFLETFVAAAALLVAGAQSAITKLPLPKSCTGVAAARHSNTVASGWSFVKIAGGLKQVRTVIWDTNGNMLVAQATRGISIHTFGADGCINSTSLLISGAQLNHGLALSPDGKTLYASSETTAYSWAYDVATMKVSGQKTIVKGMSTGVHSTRAIAVVPKDPNFILLQVGSNSNFDMASANKATGRAIIKIFDVSKAPAAGYNYNTDGEVYGYGLRNEIGFVADPNGVFWGVENSGDDFTRTENGNKKDIHTNNPAEKLNNLGDPLKTRDAWYGYPTCFTVWDPSSFSNGLKTGQHFVVAPNSSYTDATCNGKAVPPRLSFQAHSAPIWNTFDTDAKNMYVTFHGSWDRQPPTGFKVVQVPFTRLADGSYDPVAPADSMKGYNDIFSATNPGSCTANGLTQSNCFRLTASSWDPAGRGLFVGSDNSAEGEIFILSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC84</accession>
    <name>A0AAE0NC84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_562401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC84"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042109298" description="Translocon-associated protein subunit alpha" evidence="10">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3378386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27369" checksum="8BB91B039F309FE9" modified="2024-05-29" version="1">MVNFKWSALALVALRVAGVIAATEAPVSEAAPAAELKADIATTFPEADIFGVKLVNGRITKALIDITNNENGPIDVAFVGGALKTTQPLPEGAPESAATIRNLTAVKYDISIPAGEKASLPFQFVLDMNPQDIIVDLLAVITNPAGQIFQVQVHSGPATIVEAPTSILDPQIIFLYLFLTGLFGATLYFVYKTWIEALFPQARRTKPASTKKVVKKIEVEPLSGSESAGATTADFDRDLIELHKRPTTKRVKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCD6</accession>
    <name>A0AAE0NCD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_397716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCD6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="665" mass="74152" checksum="E371F894552C58A9" modified="2024-05-29" version="1">MGLSAKDALHLKEALQVAVVKCSERCLYQSAKWAAELLNALPDIAPGELDRTTSAAGSQLHPVFSPNDDPLEAALEAKELNKYLLAKTFFDCKEFDRCAAVFLPESLLSGLLSAKPSDVASPRGKGKASAALPSEQTLPTISQKSLFLALYAKIISGEKRKDEDSEMIMGPQDLGSVVNKQLLIVSRFLERWFAERKAEDSELAPSQGFLEYLYGMVLVKEKNDTVALDYLMQSIHLYPWNWGCWLEITNLIARVEQLSTVAPHLPQNIMSFIFHANTSVNLYQQGPDLAAAINDLLNIFPTSSFLLTCKALLNYHSKDLMAAEENFSSLLALHPHRLDSLDHYSNILYVLNMRPKLAFLAHLCTSIDKFRPESCVVIGNYYSLLSLHEKAVQYFRRALTLDRSCLSAWTLMGHEYVELKNTHAAIESYRRAVDVNRRDYRAWYGLGQTYEVLEMHAYALWYYKKAAGLRPWDGKMWQAVGSCLQKMGRDRDGIKALKRALLADSYYDSTASSFGSTGTIDRMAQMDPEVLLQIAIMYDRLDEEEEAKAYMELCVAQEDGGQDGADGGALSESVAIHRDSPGGVASDELADGRPEKGSGHEGTGVTVATSKARMWLAKQAMRAEDYPTANRLAMELCQDGVEVEEAKALIREARSRMELANMMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG26</accession>
    <name>A0AAE0NG26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_395896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG26"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042030626" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="38669" checksum="6BBD3133DB67DFF0" modified="2024-05-29" version="1">MIANTVLATGVAAVLLGAANGHMIMNTPTPYNYHKNPRLVQVDPLGAAHPFPCQGLSTPEFVTPITAGSTQLVNFTGGAQHGGGSCQFSLTYEYPPPKDKSKWKTIYTLIGGCPVSAAGNLPEGGLIDQDGRADAVHCGNDSGTECIRQFNVPIPKGLPSGNATFAWTWYNKIGNRELYMNCAPVSIQGGSTDANFFNSLPQMFVANVPGECTTGQGVLNIPNPGNFGKVLEQPAAGSEGSCPKANGIPTFDGVSNKVPAAAPAAATTSSLAGPSKSAGDMAVISLPPTVVTIVPTAPGSPMVIATAPNSPIATAIAEPGVGSTSTSSSAVPCSPDGVIVCMAPGFFGLCDHGKAVKQALAAGTTCSGGKIVRRIISSWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGZ0</accession>
    <name>A0AAE0NGZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042032633" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="15222" checksum="987693F28969D4F3" modified="2024-05-29" version="1">MLGLLAMLLAAAPMLLSTADAKPERIRSDQSPTFHYTLQTYPKNSNTIQSTNTSLFMNIAASESTSYKTVTFDKTATTTAWGLEGDTIITTRSSGFGRQLDFVVCRLDSQYWQVFFQTGSAVPSGACSNYQSLHLPCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA3</accession>
    <name>A0AAE0NHA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_204045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="803" mass="89049" checksum="D6C09BF584F902BF" modified="2024-05-29" version="1">MADTVAQSKEAPPQSAANPKPAKELYPMSAWKYDMVLWTMSILADLFFREVHPRGSWKVPRNGPVLFVAAPHANQFVDALILQRTLRHEAKRRVSLLIAQKSVHGFIGWMSRQVGAVPVGRAQDSATAGKGAIYLPDPTNDPTLIRGIGTNFEKDAEVGGMIFLPSIKGHTGLSVDIAEILGPEEIRIKRAFKGKISVSQLTGRDDIDEDGKFQNKDVKGSREGFAGTKYKIAPHIDQSKVYDAVFNRLRNGGCVGIFPEGGSHDRTELLPLKAGVAIMALGTLAESPDCGLKIVPVGMNYFHAHKFRSRAVVEFGQPFEVPAKIVELYKNNQRRDAIGQLLDMVHQALSAVIVSTPDYDTLMTIQAARRLYNPTGKKLPLPVVVELNRRLALGYEKFKDDERIVKLQQSVKEYNRQLRYLNIRDHQVQYAKMSWPKVVVSFFYRLSKLLVLSAGVLPGLVLFAPVFIATKVISRRKAKAALAGSAVKIEGRDVMATWKLLVSLAFAPILYNFYTVLLAYRVHLDRLWGHVPEWVPIWMVFLAGWIFFPSITYAALRFGEVGMDIIKSLRPLVMCINPSSSYNIHQLRERRAELSAQVTDVINTLGPELFEDFEHTRLVADPTAKAEVSPTQLSFPKPRRDSGMSSPGGSYPDGELESPTSSNGSVPPSSSLSLSLSRRNTTLSSRAIPRNESFSNIGQVALFATRPPSRNRSRSSSSGGGGSGFGSMAGFPVDQFTALDSKEHFDEASKKIREAMRERGEMRRRKSSKASRGSREGRDTWIDGAESDEEDGDEYEEARTKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHE3</accession>
    <name>A0AAE0NHE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrodipicolinate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_450863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHE3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40032" checksum="1059224CBEE8479A" modified="2024-05-29" version="1">MSPHNDAPSPTTGSFTAGFNLFRPQASSSLITGHLAPETHSPLSSSYSSSSLEAPGFHMARPLVPGVYVPTMCFFEEETEDVDTATIARHAVRLARAGVTGLATQGSNGEAVHLTHSERQLVTATTRKALNDAGFSRMPIIVGCGSQSTRETIQYCREAWEAGGDYALVLPPSYYAPLFAPASSTIIEFFNAVADASPIPIIIYNYPGAVNGMDMSSDTIIQLSAHPNIVGVKLTCGNTGKLNRVAAATRKLSSKKFDPSNPEFLVLAGSADFSIQSLVAGGHGILAGLANLAPKACIKTIELYKQGKYAEAQEMQEIVSEGDWTAIQGGVVGVKAGLESWMGYGGHARSPLPKPTADQAKKWKEGYRDLVLLEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHG7</accession>
    <name>A0AAE0NHG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_207934</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042074743" description="Crh-like protein" evidence="20">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="28"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3381540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="41100" checksum="C64C20BFCADCF3A6" modified="2024-05-29" version="1">MLPKFITTAAVALVATLASAQTFTDCDPTKKDCPNPKAVGSKIIDVDFRKGANSFFNVLEGTKLTYDDKQGAIFTINKETDAPTISSGNKYIFFGRVDVTVKVAPGAGVVTSFVLQSDDLDEIDWEWLGGDAAQVQTNYFSKGCTQVYDRGGFSPVGNPQDNFITYTINWTPEKLEWIINGAVVRTLLAANAKGCSGYPQTPMQIKLGTWVAGRKDAPQGTIDWAGGLTNFANAPFNAAYQEIKIQDYMGGQGATEATEYQYSDRSGTWQSIKVVNNGVEAPSNGGSTKGTSTTVAPTTSSKGSSAQITSSTVTSASSGSAATTLSTVTSATTAASATTTNAAANVPNNGANAPASGTATTSTSPAAPTSAAGKVTFTFGNVAAMGATLLFGSLAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNI0</accession>
    <name>A0AAE0NNI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_170871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNI0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041942458" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3384791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63081" checksum="7DCAF172C0500168" modified="2024-05-29" version="1">MKGLTTSLLPALATVAVLGLVPAALAHGDDEMKMGEADKPLPEDQYAPNYFAHPEHRGAIYAHIALMVLAWVFMLPVAVMMSLARSRLTLLAQFIFLATNAGGLLAGIFYNASTPDLYPNNAHHKLGWVVTWMVGAQVVVSLLGRVAGVLTRKPSGDRQGFIPVSTEAIAEHESRFPGTRRFSNDSGQGTEPISESIRVSSGVDSPSITLREAQKEYNEADGDDDIPLFPRAGKVYLLAHKVASKISSRFWKPFVFAYNVVDRTILMLGFVALCTGVIAFGRFFEGGQIFTGLAHWIKGGVFFWLGIFTLGRWAGSFGDLGWAWNVQPKREDQKWRPSAEFVESALILFYGSTNIFLEHLGGWGGEWGEQDFEHISITVLFIGGGLCGVLIESTRMRDLLNTTVEDAAHETSDDAYSDEERNELRQPETYPFSMNPIPALVILLLGIMMSSHTQDSMVSSMVHKQWGNLLTGSSVARGFSYVLTYLKPPKSIYPSRPPTELLTAFGLMAGGIIFMASSGDTVDGMVHYQLDAMFIYTVTMGLIGLLMAWILIVIALKGWAVQKERSHATSSCSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPB8</accession>
    <name>A0AAE0NPB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPB8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042059286" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19804" checksum="E8B1A805D9F8ECFB" modified="2024-05-29" version="1">MRTATPLALAPLLFSGGSLALALDGNNFAHYNSRAVVDNCTESSSPSSSPYWKIDDFVLKVYDWDNGGSMGTFGFKAYYSATNSTVECLVQDVDLAKLGGNVGGKWSKCSTAGAEFQFDFSAISLTMKETWTCSGSPGTIFNANATGRLMIHGCLDSDTDKGVESDCHLMEMEMPANVTSSTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPN6</accession>
    <name>A0AAE0NPN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_494432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPN6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="591" mass="65209" checksum="F9EA66FE577E299F" modified="2024-05-29" version="1">MSESVSGQPSHGSKTPSDCTEITYLYLTFDTYIPLANTTITPSARPPTPSPPPDLKKYDNPMSWPNSRKYLMLSLSCTATFLTAYTASAYTPALPLLQADLNAPSPLSVMAGITTFCTGFAFAPMVLAPLSEMNGRYPLFVVAGIVYVIFQAVCGLVRTLTGLLVARLLVGIGASVFSTMVGGVIADMWDKEERNTPMALFSGAVLVGTGAGPVVAAVMAHRWETDGDKWKWIYWHQVIMGGALMILLVVLFKESRGSVLLSRKARKLNEWYEQLEREGYFGIWSGSSSDEASPRGLSSMTAPTSFQRVRWLVKEDEERSSIYKMISISVYRPFHLLLTEPVIFFFSLWVAFAWGVLYLTFASIPIVFRRQYLWNIEQAGYMFVAMIVGAILATVVGIWQEQILHHPHWVNSPPPPPTDSSNEACPSRRRVGDDEARSSSAVWAFMRRHFPADAPESRLYFTCLTSTLLPIGLFVFGFTARPEIPWIAPAIGIALATMGILSIYLAVFNYFADTYHKYASSALAAQSFCRNILGGVFPLVTAMMYDNLGEAKAGGLLGAIATALTVVPWVLVFFGERIRARSPFAKQLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ22</accession>
    <name>A0AAE0NQ22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_543963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042096471" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1954"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1988"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2012"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2044"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2078"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2119"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2163"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2202"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2304"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2351"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="71"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1870"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2378" mass="266628" checksum="67B49DC45FE7B747" modified="2024-05-29" version="1">MTPLALLSTRVLFTFLTTTTLVTGLRYDAKEAEYNLNTNRTAINPLHYNGSRPDGFDYMPSPDNWRFPYYTLFLDRFVNGDPTNDNANDTLYETDMMSTQLRFGGDLAGLTESLDYIAGMGIRAIYIAGSPFINQPWGADQYSPIDLTLLDKHFGNIKMWQTAIDEIHARKMYVVIDNTMATMADLIGFEGYLNTSTPFLLEEHKVLWKSDRRYPDFDIGNTYNDTCKYPEFWLEKGERIVPDGLKGCYDSDFDQYGDIEAFGVFPDWQRQLAKFASVQDRLRDWEPSVAARLEHFSCMAIKTLDIDAFRIDKAVQVTVDAQASFSRAMRKCALEVNKKNFMVVGEITSGNTLGSIYLGRGREPTMADNLDVATAMKTETRDNTDLHIRDLGNSALDAGAFHYSIYRYMVRFLGMSGNLEAGYDLPQPLSWVTAWNHMIRTNDFFNANTGLFDPRHMWGVTNQDVFRWPTIEQGTERMLLGHFIMTLVLPGSPLVYYGEEQELYVLDSTASNYIFGRQSFAPSPAWQAHGCFSLENGLYKNWPLGKGANGCHDEKVGWDHRDPSAPVRNIFKRMYALRDKYPVLEGGWLLEELSKQTEPVLPPGTETATETGLWGIVRTMHWDSQKDEKDVEPVWLMFHNRGEAKTYTFDCSAEDSAFLAPFDHDYIVRDLFSEKPEIKLTESTKKNPYGDGKKNSGCLESVEMQPWEFRAYVRSKVYLDPAPMITKFSPGHDTPIDSTNANGKIQLSFEFNVEMNCASFKKGFGAKAIVDGVGNGTDLAFDVECPTSFNATGKTKIPYTGAIQSAWEIPVTLLNVPEGIVKITVNNTAAEPLSKNASTNAVDHFLLRFGRPNNPVIFPRTGNYSYDLLSVESGTLFVNHDAPGATQWRYTTNWGSTWSDWTTYSSNKKRSVVSELPWKGTALQAWAGKHLTVQYFSKPLGSSAFMQHSDSKDVPHRREFPHIKIHGPYNKWGYDAGLPGSMDIVDHHRWELHFMYEWPAQFQLNIWGINEDNQPDAGAIFGDIDNDGIIDRLPPSSLANNVINITGPPTMPALAWKLVYNDATWRIDKVAVGSVWIQIVVFALLAILPVFFAVLALWIYVRSFYQVKVNKSGFSAKGWRPLKLGALARLDMKNSRGVEMSAITPPPPPSATMGPFGGDGGRRTVLIATMEYNIDDFKIKIKIGGLGVMAQLMAQSLTHLNLIWVVPVVGDVEYPFERMEEAEPMFVDVMGQPYEIKVYYHVWKNITYVILDAPIFRKQTKADPYIARMDDIESAILYAAWNSCIADTIRRFPVDLYHINDYHGAAAPLYLLPQTIPVCLSLHNAEFQGMWPMRTPEESKEVCEVFGLPPDIVKDYVQYGSVFNLLHASASYLRLHQRGFGAVGVSRKYGDRSLARYPIFWSLKSIGQLPNPDPSDTADWDPSQDVSKQSKDIEINQSMEEKRGDLRRQAQEWAGLDVDPSAELFVFVGRWSLQKGVDLIADIFPSILEKYPKTQLICIGPVIDLYGRFAALKLEKLMHQYPRRVFSKPEFTQLPPYIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGARVGGLGQMPGFWYTVESMTPSHLLQQFRMAIVSALECKTSKRALMRAWSAKQRFPVAQWLKQLDELHSQSIRIHHKEAKKRKLEVVSNSLNLTRPSSRASNISYFDPGPGQVLSPGLDTGRMSPGPMAPPSRVGTPTLRGLTSPGLQTPTLPWAGGASRSNSPRASIASSINAPFYNHNGARDSTVSVDSFAIRAQKDGISSPTIGPDGGLGFPRPAFMAHRNSSLLSLPDVVGDRQDLKLQQVDQFFNDTSGEYYAEFDEMLDAMNAQNSISDMCIENFLKKSEKEWFARYRDAKLGRDSSRTRSPAPGSRPGSRAGSARDASVVSRGRQRHRSLTPSGLARSVFETSPPPMHNVDDEFLLGDGYKAPTGLKKLLSIRLGDWPLYSFFLAFAQIISVNSYQIVLLSGETNQKPEKLYMVAGTYIITSLLWWGMERNFKSVYALSIPWLFFGLAFLMLGVAPFLGDWRVAEAVTNTATCMYAAGASSGSLAFALNFGDEGGAPTKQWITRALVVSGIAQVYSLALWYWGSLVANADTTATIFLPGSKIPQALVVCVPVAIFLWVIGIILFVGLPDFYRQSPAKIPGFYVSLYRRKIVPWFFVMIIIQNYWLSAPYGRSWQFLFASQFIPGWGVFLMALGFFVVIWGLVLYGFSHFSDEHTWLLPIFAIGLLAPRWAQEFWATSGLGWYIPWAGSPMGSAILSRCLWLWLGLLDNIQGVGLGMMLLATLTRQHVLTVMIFAQVVGSVFTILARATSPNALSANTTFPDFSQGLMPGLASQWFWVCLIMQLIIPIGFFKFFRKEQVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQB1</accession>
    <name>A0AAE0NQB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_394988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQB1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="360" mass="39900" checksum="DF0D565061E776D1" modified="2024-05-29" version="1">MSTKARIQEAAGQNEDLLRVLAETERAAPALARHQQLMANLAAQIAESDARIQALDLARQKELKEHEKMQGSVVKRLAYRATGKTAEFQAKARQEEAEYFLALEAQHRETETNDQLRVQLLAQGKLETELTREAARHGEAQQALDELYEGIFAGPTPGFPDEDRKEEAATSAAKTHREVAARAEGENRAVGFLGEARQRAEKALPRMDRAMHYSKRHPLNNGVGADLCEGDALFRATMDVIAARSLVIDAQSAINESTKIPMGATSSTAEMPSVTSQFHSWTTDTAFQEEIKRATAEVRCFVDAVAQLLAQATERKSQIADEVGRCETEVKETRRALQEVREEAFERVVASKENLKKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQP9</accession>
    <name>A0AAE0NQP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_473788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQP9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="275"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="957" mass="104243" checksum="7D8F69D10EC398D1" modified="2024-05-29" version="1">MAEEEDFSALALTDRWVHKNWKVRKGAYEEAAAAFEKSTDEYDPAFRPFVQDSGLWKNATADSNVAAQQEGLAALCAFLKFGGREGAVRARQHAVTPIVEKGLSSTRAAIKASSIEALLLFIELDVAAPVIEEILPALSNKQPKVVAASLAALTQIFHNYGCKTVDPKPVLKVLPKAFGHADKNVRAEATNLAVEFYRWLREAMKPMFWNDLKPTQQTDLEAQFEKIKAEGAPKQERLLRSQQAAKERAPVGGAAEGDVDDGDEVDEPAEVDVFDLAEPQDVYSKIPKDFFDNIASSKWKERKEALEALHTVVNVPRIKDADFGELNRALAKCMKDANIAVVTQAAHCIELLAKGLRKSYAKHRSTVMQPIMERMKEKKQTVADALGSALDAVFLTTNLTDCLEDITTFLVNKNPQVKEGTMKFLLTCLRTTRDVPKKEEIQMIVESAKKLLSESSEALRAGGAEILGTIMKIIGDRAMNPHLEGLDDLRKTRIKEFCETAVVKAKEKPKAPPPPVARGPPPGGPKKMVKKAPGGAKKPAAAAPPPPSQYAQQAPALAPQPTSRAALGSKLGMPKPAGLGGLKAPQGRSLPGPGLASPRRPAAAPSPPLEEEEEYSPPPKPAAPRLGLGRGGLAGRSLVKPSAPSQPLPPRSPSPPSGLAHMERAELEELRDANERLLRQLEDARHDRSKLHSEIQELKNQNAGLIEDHTRDVLSIKAKETQLVRARSDAEAAEQTNERLRRELDRLKRALSKAEASGASARSGSPGSPSLGHRMMSPTHNDNDIYRDGDYPPSANRNRGSFASTRSEEKENGDNAPYPRSKLASNIRGGLYTETPGNNGRGSPARGYRQAAADDADHRNDQRNDQRNDNRNEYRNDYRNDGASLGFRDPPDRAGSRPDSRPDSRADSRAGSRRGDAPASAASAGNQESWKRAAEVTSQLKARIEQMKAKQGINNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT31</accession>
    <name>A0AAE0NT31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dicer-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_152862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="502"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="13">
        <location>
            <begin position="693"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3387208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1535" mass="171551" checksum="64376A585E62208B" modified="2024-05-29" version="1">MFKRREDINIYETLVTLNPTRLVLKPPRLRRGTPAYSSSSSTEPRKTTTISGVYARASCLSRATLSTYPGHHPKPPLPSAPGASQVTKMNGFDAAWPSSSDEDSFEEFLDEDIYPSEYSDEDGDVFHTPRDTFDDNIDPSEEPPPTALTMAARPYQLEMLEASLEGNTIVAMDTGSGKTQVAVLRIIAELERNDKRVWFLAPTVSLANQQLGVIRSQIPSVHTRLICGADNVKAWSTQRVWDTILFEIRVVVSTYQILFDAARHGFVPVESLSLIVVDEAHNCVRNDSVARFMREFYWPAKNRGQPIPHILGLTASPLMTSDLKDVELLEATLDATCRTPKIHRDELIAQVNRPAMIVVPFEDSPDPAYYGGPTPSMASLNQAYLGLDIKSDPRVLRLRAENTPRSREELRRVVMKNDTYAQRQMKTLCARARDVCKHLGPWAADYYIHKAISRFLVSSNGDDASLEGWTDDEKLYLATALRSVNAPSPPDEPTHLSKKVVALLDILERYSEDPVGIVFATERATVEVLSHILAVHPRTKLRYRVGSMVGTSDVPGRKRDFLDLSRGKDNLFSLHRFRTGRTNLIVATSVLEEGIDVPACNLVVCFDKPSGLKGFIQRRGRARKAVSQLYLLINDMTDQSVSEWQGLEQEMKRKYEDEMRERKVLDEIENSEVPDYPVLEVEATGARLTINDAKAHLEHFCSTLSSRKFVAWSPFYVIKHMDGHSKFPLLKATVNLPVSLAPELRVTESLQAWSSEANACKDAAFQAYAKLYAAGLVNENLLPINDSEMKGDIEARPGLATVREQLNPWPEVARAWKHDAQLFSRRLTISSQDKSVIAEFELMLPVPVPYMEPFTLYWDSHSSWLVSMEQGVQTAQSSTGEADHTSVLLSLAFCHRWDTIAKQYPFRLVALDRDLSVKDIGANEFNDGAVSGPEGTYLVRDALNRNHPYFYSERLSSKPPAALIQRLQEDFESLPEDGQYIAVKTWPKKAGYFRPTVPNPASSKPYRRILPVDQATVDNVPAVYPKIGTLIPAITRALEVHLVAADLLENRLKKIGITDLSLVATAISTSSSKGPTDYERIEFLGDSILKFCTTINCTAKNLKFPEGYLSLMKDGIVSNSRLFRAARDFGLDQYIIYKTFTLQKWRPKFVEDILENPPPANAMRKLASKTTADVIEALIGASFISGGLPKALACMSLFLPEVKWQSIESGRQVLYREAQENSPLPSTMRLVEPLIGYNFTKKALLAEALTHPSYNPPVLKSQNQPITIVSLDRAEFVGDAVLDYIVVTKLFAINNPAPLKNSELHLLRTALVNADILAFFVMEYSISVERDVSTTCDSDSDSDSDSDSDGDDEVAKPHAPSKVGYPLWSFMRHASGDMGVIQRATQERHLEMREEILAAISTGTHYPWALLARLQAHKFCSDMFESLLGAVWIDSGSLDEAERIVEAIGILPFMRRILKDEVHVLHPKEELGRLAGNEKVEYLMQEFKYEEDGEVSIGCKVMVGERCVADIKDGVTKEEARTKAAEQACRVLKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTJ6</accession>
    <name>A0AAE0NTJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial GTP GDP transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_157752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTJ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="303" mass="32952" checksum="CCA23BFCA4E634BD" modified="2024-05-29" version="1">MSPPSNTAHKESNLARLLGSGSAGIAELAIFHPVDTIAKRLMSNETKIAGLPQLNAVIFKDKAAASAGRKFVSLFPGLGYAAGYKVLQRVYKYGGQPVARDYLTLHCAQHFESAFGKKTGKAVLHSTAGSLIGIGEIVLLPLDVLKIKRQTNPESFRGRGVLKIIKDEGFGLYRGWQWTAARNAPGSFALFGGSAFAKEFLFKLNDYNKATWFQNFVASIAGASASLLVSAPLDVIKTRIQNRNFEDPQGGFKILTNMARNEGFSAFFKGLVPKLLMTGPKLVFSFWLAQTLIPAFDIAFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTL2</accession>
    <name>A0AAE0NTL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">rRNA-processing arch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_392089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTL2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="385"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3387491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120272" checksum="E098981F8B621C92" modified="2024-05-29" version="1">MDDLFGVFEEQPRAPKKRKAAPDVEMAGQDHAEPQVTSNNEEAPAADDDHDQAQGDTKRRKKEGEAEQPVLTDSFQTAESREVGAAQGFAATTNEVESIVLSHNIQHQVALPPDLDYEYIPLSEHVAPAEPARTYPFKLDPFQSLSVASIERDESILVSAHTSAGKTVVAEYAIAQCLKRNQRVIYTSPIKALSNQKYRDFQAEFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKIRGVVWEETIILLPDKVRYVFLSATIPNAFQFAEWIAKIHRQACHVVYTDFRPTPLQNYFFPAGGKGIFLIVDERGNFKENNFNTAMALIEDGKGADPSDINAKRKGKGKDKKTNKGGQAPNEGADISKIIRMIIKRNFQPVIVFNFSKRDCEQMALATSCMKFNAPDEENMVDNVFENALKQLSDDDRTLPQITHILPLLRKGIGVHHSGLLPILKETIEILFQEGLIKVLFATETFSIGLNMPARTVVFTQVTKWDGVQRRPLTSSEYIQMAGRAGRRGLDDRGIVIMMVDDKLEPETARAIVVGHQDRLNSAFHLGYNMVLNLLRIEAISPEFMLERCFFQFQNAASVPQLEKELMALQQERDNMSIPDESTVKDYHSIRQQLEGYNKDFLAVIQHPNYCLEFLQPGRLVNIVSPIGIDYGWGVVINFVPRQAPKNEEPAYSPQESYFIDVLLKISTRSKDFSADYKVDDAMPEGVLPQEDGENSKWNVVPCLLTCLKALSQIRVFLPQETVNRAQLDGVGKSVNEVNRRFPDGIPILDPMENMGITDDSFKRLLRKIEVLESRLVANPLHGSPLLPGLYQQYEAKVAIGDKIKEKKKAIAKAHSIAQLDELKSRKRVLRRLGFINEAEVVQMKARVACEISSTEGHELLLAELLFNRFFNELSPDVCAAILSCFIFDEKVETAALKEDLAKPFREIQAQARIIAKVSAESKLDVNEEDYVNSLKWQLMDTVMAWASGKPFSEICKMTNAYEGSLIRLFRRLEELLRQMAEAAKVMGSEDLKDKFELSLSKIRRDIVSFNSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTM0</accession>
    <name>A0AAE0NTM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_509127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTM0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="21820" checksum="5269082A56FF597A" modified="2024-05-29" version="1">MQRPLSICTWTYPSHVFGALRPVRMYLLCAARAREEEYGSVLHMNMQRPGSLVAVLYSAFWCPSGSSTGGLSEGPMRGLAVFYSEIKTDKVQANWPAGASFSAEGSIAAGARLASGLQRTEATDSRTVEVLFTKTSSPRKGWQGAPQEKADRFSKGLVNFLAGGLVLPLAVSSHQVFRQWYSSPQPAPASVVQGGKMDKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTS9</accession>
    <name>A0AAE0NTS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoribonuclease YSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_470473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="9">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="10">
        <location>
            <begin position="426"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3387596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="740" mass="81677" checksum="4E79A3AB1AF8D044" modified="2024-05-29" version="1">MTHPTKAIYKWLIQDSVRVGNTSSNPTTSLVYTEQDHLNTFPQIEAIDYHTTHTISSIRITPYPAGHVLGAAMFLIEIAGLNIFFTGDYSREQDRHLVSAEVPKGVKIDVLITESTYGIASHVPRVEREQALMKSITSVLNRGGRVLMPVFALGRAQELLLILDEYWGKHSEFQRFPIYYASNLARKCMLVYQTYVGAMNDNIRRLFRERMAEAEASGDSAGKGGPWDFKFIRSLKNIDRFEDVGGCVMLASPGMLQNGVSRELLERWAPSEKNGVIITGYSVEGTMAKQIMQEPEQIQAVMSRNVGGGRRNPGGESDKVMIPRRCTVQEFSFAAHVDGTENREFIEEVSAPVVILVHGEVHNMMRLKSKLLSLNASKTNKVKVYSPRNCEELRIPFKADKTAKVVGKLASIPPPTSGAKGSDAQEPQLLSGVLVQNDFKMSLMAPEDLREYAGLTTTTIVCKQRFRLSAAGIDLIKWALEGTFGSVEELTESKAEQHANGNGKAEDADTRMHDGDEVIATYLVMGCVTIRYHHNGEVALEWEGNMLNDGIADAVMAVLLSVESSPAAVKRSASKHPHSHGGGGDEALSLPTRNLHANLSPEERLERLMMFLEAQFGSDNLSPIAEPKLPPLPPSPPTSVPKKLTAAETGDDSDQGGASMDVSEDEDEKEEQELRERQQAELARLYRLGIPVPGIAIKVDKMEAVVWLEDLEVECKNRVFADRVRAVVERAVEVTAPLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU03</accession>
    <name>A0AAE0NU03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">B0H63DRAFT_470790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="51414" checksum="654756372D914DB1" modified="2024-05-29" version="1">MSAASLAFRIIYHFFYYFLYLVLLVFLLVTPADLINQAIKRKQSSNILVIAICYLVTVIIICFIYATRLYINRSVLASIPKSWIPIEKDDVNSDVRQMIVEGISRSAAIAFEARPRVPSVFPIQQLQQQQQQQQGSNIGREEKEAPTGTEKWSSWRPKLWKSVVSDDSVGINIPPRHRAVWGDIEHLGWAPPTSLDLPNLQYDTVVLELPNLIEAKALTLAPPDPESQADPPALDPEAVALLQRPDSMGLREYLTHLTEVGVLAPLPMNNEFIAKYEGARFSARPISNEQFRALMHLFAEILRNMYPLSPAVLAQYDDDDDSSSGLAPSESDIDNDAPRRGTSSSASSSTAQSVRGPRRSPDGGSLPRGVSSSTASSGLLRPAMQMRNSSANTWQYRTAPTTPKSRHTGLSRASSPDSFAQTRRPYPVSQTSTVSLRSSAGGSVIRLAGSEDDTDLPYVLMHPHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUL1</accession>
    <name>A0AAE0NUL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_166627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUL1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF5">
        <property type="entry name" value="PIMELOYL-[ACYL-CARRIER PROTEIN] METHYL ESTER ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="33664" checksum="5C7C1EA708FF76AE" modified="2024-05-29" version="1">MASVSATAPASASDAATWCLPSGRVIAYGFSYRNEPQRPTILLSNSLGAQYAFWDPVVACLHAAGYRVLRYDHPGHGASGVPRDISSTTFSSLADDVYALLTSADVSTAFAGHHSPNPGTFTPLLHAWIGVSMGAALGIVFASKYPAVVRRMVICDTIACSPVNAGVPDLFGPRAAAARELGSMEKNIAETMDRWFGQDWMSANPDETARIRQLMSKTTVAGFETCVAALRSKTFDLGPLYSGLGACVERVLLVVGENDANLPQTMDEMRREIEKGMQGGHRKVDLRVIPNAGHVCFIDGKEDWLNAVLPFLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX29</accession>
    <name>A0AAE0NX29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_536997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX29"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="550" mass="61851" checksum="8C8A17A8707AE73E" modified="2024-05-29" version="1">MLGVTVSGHQVAAAGVYNTEVLQLVLCFDGTGNTFSGSNADTNVVKLLSKLDRNDPNQFHYYQTGIGTYDTAATSVDKSWLETVRSSIDQTLDQGFGAGFDVHVLAGYRFLMRYYESGDKIYMFGFSRGAFTAKFLARMISTVGLLCKGNEEMVPFAYRLYQRYLAGDIQAFARGGRREQRTTSTANDGGDHNQMNEPLTNHSSNLDEVDEAHHHGRDELSAFSNTFCRKEQVQHHDHVEERNIKVFFLGMWDCVNSVAVLERKAPKPVQVNGTATFVRHAVAVDERRVKFKAALLAQDIRDSTNDNAEDIKEVWFPGCHGDVGGGWPASADNPLDTRGRMTAWQRFKNVWTTRKAKKASRYIDSGPFQMSDIPLAWMIREIELVGKQHPDAAVQWRLDTLKTFKARFQRKKNQALKGFIHDSLLFGYGTGFFKVLLWKFMEWLPFITRWELEGDKWVNVKFPLNKGSTRDIPPDAVLHESLLWRLRNDSTYHPTNNHGGKSAPCLKHNGKIPGLVRCGGGGGPAELQGDLEDVDPDHLTYTFDKADPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX83</accession>
    <name>A0AAE0NX83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_445470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX83"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3389264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="407" mass="43365" checksum="E10E5CD438899F49" modified="2024-05-29" version="1">MTKMQESVANRAWGTKLVPGDTNSSRNLHDGVSWGDATATGTAFDFRTDAITTPSINQLAAISRATLNDDVFGEDKTTTLFERHIADICGKEAAAFVISGTMANQLALRALLHQPPHGIIADVSSHVVNFEAGGLAHFGGAMVQAVQPSNGLYLTLDDIRKHAKVSDALEICPTRVISLENTAHGNVIPLQQLQRIRDWTSSHGTAVHIDGARIWDAVASSGATLKQIAACTDAMTLSFAKGLGAPIGAMIVGSKDLIHRAKRLRQSIGGGVRKAGVLTVAAREALLESFGPGDVDVKGVARAIHDMAAAVAGMWTSRGGYLLRPVETNMVWLDLPSAGISAASVDDLAMRRGLLTAAPRIVLHHQISAKALMSLEHVFDDLLAHKEMRIDEMTEVKIMRKGCVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY09</accession>
    <name>A0AAE0NY09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_556886</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3389786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="37472" checksum="3F742AC6731EA630" modified="2024-05-29" version="1">MTHQTSTRKERTLGALLGVHAGDSLGAKFEFMPWDAVHRQYPQGIRDMVGGGFFKWPAGHATDDTDLTRAILLAYKDAEVQRRSGNPKTNIVLLTAQQMVAWYDGNWPDRTYGRRPRDVGGATDTGIRNFKRTGDPYNSGAGEGSAGNGSLMRCIPTALFAADSVSREKESVALSAITHDDKTCTIACAAYNAMVHALVEGKTPLEAWQAGRDVASSIHARSQDSARKNAAKKVEDTLDQGKSLISVNDLAENGPTGAKNGTLVIPYGASGYVLESLAIAVAALLDPRPLEDVLIDVVRIGMDADTNGAIAGGLLGARDGVEGIPARWREKLQFGKEFAEVLDYMLEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ81</accession>
    <name>A0AAE0NZ81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_118425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="68884" checksum="9AB07674C9B1A416" modified="2024-05-29" version="1">MATASRSTTSFASGHSDHIVRADNLAEMNDAEKLAPAIPPPPPVENELFQPKSFRFWLTILCNFLALFLVALDRTIIATAVPRISDEFQSLGDIGWYGSAYMLTTSCAQLVYGRIYKFYDMKWVFLISMIVFEIGSAICGAAPNSTVFIIGRAIAGLASAGIFSGCMLIMIPMVPLHKRPAFQGLFGMVFGIASVMGPLIGGGFTNGITWRWCFYINLPIGAVSFIFMVFFWNPPKEKFEPASFSAHVKRLDPIGMVFLLPGVVCLLLALQWGGSTYAWDEWRTILLLVLFTAATAAFITVQILKPETAMVPPRVITQRSVAFGTAFTFFLAGSMLMMVYYVPIWFQTVKQVDPMKSGIDTLPLVLSLVVSSILSGIVTQKIGYYVPSMLLAPSIMSIGEGLMSTVSRDTPSSHWIAFQFLTGFGLGFGMQTSGLAIQTVLPKEDISSGIAINFFVQQMGGAVFTTVGQSILTNLLVSRLSHIPGLDPLTIVNEGATKLTAIAPQEFVDQIIDAYNYASQRIFLAAMGLAFASLLCAFGMEWRSIKKGRQGPTGESPPSASDSQNAVPGPLSGNPTAEIAGQDMERGDDKEVSKQTSTIDGRKPSVLTKKRLSGPGGGSVSSSSSLQTAEEGIRKPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZA5</accession>
    <name>A0AAE0NZA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_519580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZA5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="89" mass="10015" checksum="429638252A3DD05C" modified="2024-05-29" version="1">MAAPNHNHANYQARALIISNDCWEKFTASSEKEVSETKITTIQYETDFPFKYNNFVYRFSLPTNACISSGPHNGRPKSAGCVPIPTIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZF8</accession>
    <name>A0AAE0NZF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_108961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZF8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="154" mass="16865" checksum="306EFDF7C2789EF3" modified="2024-05-29" version="1">MTCMNQTRAWASRPQQAAKPFHLEDYTPLSLKPNPAYFLDRLPPACLCLSNHANCEPAERSGSQRQRLLQVWTGWLAGCLSVCLPDAGSRRQPLCTMSWGSSQEVAAAPRHGYKTKVGALALYLMEGGRWWAGVTLVWPIASLGSLAPPTINVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZJ6</accession>
    <name>A0AAE0NZJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_118766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZJ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36227" checksum="5920C0314BE22A13" modified="2024-05-29" version="1">MKLNSLLPLLGEEVSAPDEETFDLFSQNLPSQSLGFVDSKSTTLELTIGGRDLTIHQSPGVLSSNRAGGTTGAVVWNITPLFAEWISSANNLFFSHEILSTSSFVLELGCGISGLVGLLLAPRITQYVLSDQVYVARFVEQNIVENQPRQQLKQQRKTKGGSNKNRSSSNQQSSSSFDAGGAGKIRFAALDWETDQVTPSLTGVPEAKSFDVVVACDCVYNLGLIEPFVTTCADACRLRASSSFSSSSSSELEPGGRGEGEGEQEEPPCVCIVAQQLRDPIVFEAWLESFAKSFHVWRVPDELLLEGLRSNSGFVVHMGVLKASKLSVGLEGSNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0P6</accession>
    <name>A0AAE0P0P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_447185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0P6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042033565" evidence="8">
        <location>
            <begin position="24"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="570"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3391115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="776" mass="84127" checksum="CA9468F8C1CCDE2A" modified="2024-05-29" version="1">MLFDRQLVAGLAGGLWAASVASAATCTSNLVIDNFIKWTAGTNNLDWGNGDDGSMTSIAASAGQVVFIPKDKFSYFYESFECQQAVTNGYGGIQFTVQAPAGASFGFELQSTANCNVTDGHNSSWTVVENLTGQRQTVTLPLLGFDGTPNYDSITGLAWSVFSSYGSQWSIGNITLVCGTVDVPPPVTTTLPTTVSTRSTLPPSTTATPKPSACSNLLIDDWESQSRLTFLGYNSMGQASSDDGSMASIVVNSHRVMLTPSSTDSYFYSQFGCLDAKTQYGGISLRIRAARGTTFAVTLASVDKCGSSNLKTATQTTAQLKWTFDGTERLYWFPFSVFTGVDTTKLNMIYLSNFNAAVILGPMSFYCGTTATEYVAPTGVVPAQGGLQTATVPVSAAKNFVIDSFTNANTNALGEWHGGDDGMTATFGTNKMTILTNDSDASWNTQLANKCADMRAYSGAYLHIAYSGSNKFSVAMQQHNSLCDETISPFPETWDSLEAARYASTSDIYMPINHFNINLTRSLGFNLRGFYTKEPTVITKMEIVDKVPTGWIMPSKLPSGKFVFSCTRPNSFAFAIDDGDPALAKQVMDMVKAANIPVTFFTVGLPLLDKTTGLGDIYKDMAARGHQIALHSYTHPKMEGLPDEASIDWEINNDIGAVKQVFGSSGHSNYFRPPFGTEGARMRQRLAANLKDPNTYIVGWSIDVEDWLWAESATPEKQLEAFKRDLAKGGNLMVMHYLHNSTISYLPEFIKLAKASGKRLMRVDQCMEDPKAPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3Q8</accession>
    <name>A0AAE0P3Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_443147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3Q8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="243" mass="26564" checksum="5536B462C2175CEE" modified="2024-05-29" version="1">MSYSHELGAPYNAELFFTVPQPSQPLVRFPLPALDKDLLPMMKDRWALRPLLRLLRTYEASGRAPNQLKNGSMDPAPTVPDTICLDGGAVISIFQHKNAFTRMEKIPPSKSFYIFDGTCTGPGNVPLKVQGIGRVSLGLIARGPEMALTFVCIPALFVPTAKYSRVSLSSLEEDALMDGGNYLLANLQGKWEVGGVSIERNNEEVGYAELSKSGNYFRLENTLPSGSKSGSASPTDSEEEHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P473</accession>
    <name>A0AAE0P473_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_457086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P473"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="77" mass="8595" checksum="6723303F0C6AA0FC" modified="2024-05-29" version="1">MSVLSVSGRDVCLLLLQLISRFSFSHLYLSSPRRGVQEVCLPLEGASALFACSWQVQEIGPNKTPIAKTLFQRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Y3</accession>
    <name>A0AAE0P5Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_459474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042260388" evidence="5">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="530" mass="56150" checksum="31999533CFC6816D" modified="2024-05-29" version="1">MVSKLARGASALFTLYIGLTTATHSSSSSSTANLAGRGEVSSVVSVGGSKFNGCAALEQAGLGDLLYYAGEDEYSGTILSYYSKDVQDVKPSCILKPKTAQDVAKAIKVLNTKEGRNWPVAIRSGGHAPYPSNNAKDGVTIDLARLDSVKYKSCKGGTADGRVSIGSGARWGNVYSTLEPLGVMVGGGREGHVGVGGFLLGGGFSWYSGKRGMCADDVVGYQIVLADGSIKRATAKKNPELFKALKGGLNNLGIVTRFDISSFPAKTLFGGITAFPWTVAEPVVEKFVTMIDNNHKNQAETGFISLSWSTGYPSPSVAFITANVDGVADSPSFRGLEALGPPVVDYRFPQPLSGLVSMLSTTLGSYNVWYTLSVHNTMDMARKIISVFDSLIAEVSSVIDEPSVQIIFVLTPLPKTYGQHGANILGLDKMAANSFVIQPEVILPSQKFQPLLQQKLKAAVAAIESYAKRTAQDTPWRYINYANPEQNPLASYGAENARFLSKVAKDVDPLGYFQGSGVSGAFKVSAVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P656</accession>
    <name>A0AAE0P656_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_459664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P656"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="32235" checksum="9E20B91148A1C2A0" modified="2024-05-29" version="1">MNSIRRSAVSSALAASRTVATKASTTSLAAQLSRKTNIAKPVFAQAARLFSKSARALNESRSQEEGFESLEQKLESPGTGLEKRENKQTPYGVFVRNLIFDATEEHLNTSFEKFGQVAWVNVARDPRGLSKGYGFVYFTNADDQAAACEGLNGTFWHGRRITVMPRSGGRDGDRAQARQRTSEPSAQLYIGNIPYETTDVELNRLFKGLDNLKDVRVAVDRTTGWPRGFAHADFADVESAQAAYERLANMKIGDRTLSIDYAAGYIRGGNDRRKKPEARTRSHEDNSSNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6E5</accession>
    <name>A0AAE0P6E5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_426185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6E5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="192"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="47457" checksum="74A58EF98F1880DA" modified="2024-05-29" version="1">MDGDPAVESSLDSFSLTFPLPYRVAFTVVLAVWGWGLNLHFLHVRRIDVPSLIRYPGRTSTTQLPHHGSTYRLATFLSLTSTLSLVTFWLFTRRDAQRVIDYDWLPMTNLLVLAVLFAVPLHSLAVSHTGRSRVLQTLKRVSIGGLAEPKDGKFGDILLADVLTSYAKVIGDLFVCLCMFLTRNGSATDRPDRGCGGTVIVPLIMAVPSAIRLRQCLIEYMRVRRAPYKESVGWGGQHLANAAKYSTAFPVIVLTAVLRNIKVDPGHTVPTSYTSLYRAWVAACLLNSLYSFYWDVTKDWDLTLFAGTRERNAPGQSFGLRRRLLIHKPGVYYAVILLDLVLRCMWMTKMSSRLDHITDFESSLFVIELLEVFRRWVWVFFRVETEWIRSTATLEVDDILMGDFPDNNSNKYEDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7G7</accession>
    <name>A0AAE0P7G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_58184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7G7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="525" mass="56825" checksum="97A0CDAB71E36771" modified="2024-05-29" version="1">MSGYVQDPDQPLRHACDRCHSQKLRCPRSVDSNKANPDEPCSRCRKAGMACIVSLRGKAGRPSKVDKKKAARSSASSQAVRSPDREFPVDQSWGQEAEDHLISVLDGSRATMSSPGMADDVDMEQAPSQHPATHFSAAHGNYPHSIAASETACRAADELDHPGFDDPFLMDFDTGLDLPTFYISHNAITDGLEPTGNMLQPPIIPRMEGTIAIDPSLTDMLSKPSSLQQKQQQRKRHPSPVAEAPGPQFCSTTCYQKLSDLNARILVSFAKTESTHDSQIIKDVVGFCGELIDTARATTAYFAGSSAAGSRSRASTMSRAESFGEQPSSGASSRRNSEWQVMLNNGHSEPPPFSHNDQSVPGSAIIFLLLGCYTQILRLFEVTTNRLWARYHNAGSDSSSSSSSICGNNTNSSMQQDGGDLGTVSPLLEAALAVHTVAYLLSRLNRSFTVDSDQPQPAANKSSGNTNSIGTPVDDICDLQSWKRSFLGGSGKESDDGLLGQAFGEISERVQWLMMKTQHLQQRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Q1</accession>
    <name>A0AAE0P7Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_444945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="264" mass="28250" checksum="31963065B75527AD" modified="2024-05-29" version="1">MSAIKEIMSLDGWTQHVSSLPPSALLIVSFYAPWAAPCAQMATVLSTLASEYPVTEPLSTSWVSVNAEDLSDISEAYNVTAVPFLVLIRNGQVLELVSGNSAVKVRNAIESHATQPARSGSATGGQAANGDAATVEKSSTELTPEEAEKQKEDLFKRLSDLVKAAPVMLFMKGTPSEPKCGFSRQLVAILRENAVKYGFFNILADDEVRQGLKEFADWPTFPQLWVDGELVGGLDIVKEELASNADFFSAYSAKASGDNSAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7X2</accession>
    <name>A0AAE0P7X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_427002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="217"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="578" mass="64209" checksum="E7567EDB0BBDC3D2" modified="2024-05-29" version="1">MSGFEIAGVVLGALPVIIAAVDLLRDAKQKTLIPFRKRHHVARLANALLLQKQTIAETIRLLSVHSGCASHDDGDLSRLDDDPLGYLEDEDVKAQILDFLGDKNHAALTGALQESSRVVKRVAKQLAGLVPSRQNEPDDLLGIIEANRSAKQHQADLLPRFKLMIGSSDLKKSIEDLDAASNSLDRFSRLVLMNRSTSTTTDSSRKSRTVRLAKALRQVRGFANDLYTALCQCCQAGTCHSKHEANLFLEDRVDAADDILRSMRQQKTDQAAALIFRLIFAATLLAPPQQWWHELPIQVLKDTRDTTFEPASLTSRTRFVVPDNATTGDITSAMAALTLVDDFCSTIITARSRNPAVAFVVSRGRKMGTITADKCTILSQVEPKRISLKTILSDSGSVADGIGFSLRFRMLLALRLASSLLQLSQTRWLGHAWSKEMVYFLMQPMPNGGKESVDFSRVFVTAPIDTQAPPQGSSPEPKLMLLELGILLLEIWHQTTLEARFSLGKPPDGYYQRLARAVEWLEDNSNPPPCLYENAVSYCIRGMLGGQVRLTTWDANDFWNWACQDIIEPLSQNCKQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7X3</accession>
    <name>A0AAE0P7X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_492050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7X3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="263"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="545" mass="62818" checksum="29F1C2DBA5AC5813" modified="2024-05-29" version="1">MEKVMGGSNNDTAQYDTTKALDVVVRSRRGQYNNTILEHSSDKGTGGIENSEDYFAQRKEVLEREASLGFDYACQQKASEDELQANEILQTLRHNDDICVYKQEHARKGYGGQTHRRFCGDHFLSNVELIEETEIFKVAQKIPKGAHLHIHFNANLPPNVLLDIVKTQPRMFITSTHPLTAKNEFINYSECQIEFRIRSTADELPSNLFPADYKSGNTMRFNQFLEEFPNNYHRSSVDDWLESKLIFTWELFDKRTKMMKEYTKRCLQKFVRDNIQYAEIRVNFIQANQIWLDDGSGQINNEGIMYIIINEYEFRKTNAYFNGLKIIYCTPRSFPGDQVGAALDECASFKRNQKYSKYVAGVDLVDEEAAGKPLKHDERLSIPFLFHSGKTIDDTEGNLLDALLMNSRRIGQAFALQLHPYIMQQIKQKGICLKTCPISNEILGLTSRMSGHSIYLLLANNVYCTVSSDNPALFKSTLSHDFYQVLAGNSDITLHGWRQLIEWSLEHLCTSKDKSVGIYSQWENHWNEFLQWIIETYGGVKRMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8D7</accession>
    <name>A0AAE0P8D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="968" mass="106254" checksum="58F9444209D65E12" modified="2024-05-29" version="1">MAPRTRSRVQDLEGRIYHSSPALQQVEFPARRHIVKTYGKRPPSARSLRQQTLTQIDYVTQSASKEDPEMSPTKKEPPGKRRKTMGDTPNSSFHTQTLTQLLSEKGENDAGDDPMLIKDSDADTDDEQDMIDLPMLPPWSAPKRKASESDGKSKANAPSPVPETPSHKKIKVNLDEVPSSQPTPFTPMLDRYDQIPERSPLKEKSTNVDAAPITIESMSKRPRNMVIQDSYSPGSRLSSSIAAQSSPPQKATPTNQPKRQPLGEIPVPSLELSEDVSVLLGENQTPTQNRAGSGRKRAFVEIPDSDDELDAFSPSPLKNSSVRRTPQCPLITGLFGSIVRSGGSTATSGPGIFNDESNGILANDDTGITTPTVKEAVAVVTSNNTAAISAEPAEEREDDEEEENEEEEEKGDEEVEPEEEREVDEEEAEALPNTTNSEVVEPSSLTSAPVQDHEMTEQESTEVTSSEAGDPPTPTPAARRVHIELSSSSVRQTADLGTPTRAVRRVHIELPVSSALEDIEPKTPTPVGRRVQIELPRSSIGEVLEETPRPLRRKSPLTAQRHTQARSQRHTQARSQRQTQAKSQGRSQAKSQFYSQGLESQRVPLDVIRSLGPQTDRTDILISIHPEPTEAIVDGTKDHEFRNYKFPPNVLRCWIYVTKPVGEVRYMVVLGPAKEPGEIDSDSGVGNAEFNDGTSGYKFAHHLVQVYELNNPVPLADMKDNGLGDGPPNRHRYIPPAIVGQLMANLRCSLFTDGDEELEEGLDDGEEDEDVTISQELAEQIRSDILSSTQMVPPSSSQRGRHHDDVIPASPEIIPASHPTTTPTAPAKTSAVRSSTRIRSRQTQKQQQQLQKSPSSIRRRHAANYIRPSQATTASEPSSPSQDFMEDDDDVGTSLSIPRPLPDSSGPSLRSLIDTFDDEIEQGSPIRLPLGIVEGSSQSAAMMQDSLLVDDVRRPPEIWDSDEGDFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8E0</accession>
    <name>A0AAE0P8E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_492118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8E0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="22517" checksum="C42A02298C8B99A2" modified="2024-05-29" version="1">MPFDFKKYDAKCAALSAEELQREWEHYTRLISGAATSTTVSGLAIPFTLGVSMIGVGMAAPAIHNARKKREIIEKHLQKHGTTHHTRKRDVVSSMAISGTIGVVTLGVGSAGADAVATVGAEHGISAIVENETAIKIVTHAALDGAGMGIEHMYTHHKKERDAEKAFKKAGTFQAVADAKLPASSRPTSTVTTMLCPSDDNPRPELFLGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVW2</accession>
    <name>A0AAE0TVW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrase/ferredoxin-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_475977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="393" mass="42356" checksum="90FC377E877C762B" modified="2024-05-29" version="1">MDPSSSTDSPLPAAVAAAASTKNHSSNSRNKQAPLTRRTMASGFKSLINSAKKLAIGDSGSKASIDDLFPHVDKTVDGDDCDHDCDSCEVQYPKNFKIDEDDDLYGFIKGWSTHVLVATGKTDWVRDVADEKGSVMQAIGNSKGPTNGKLMLSASNIPTPHHTSDYSEPTTVLLLPAFLIVDNVTPATVPTLISELINKAPTNTSPLGPVSLPASLPAPLPEGTPAALKELTTRACPHRALILLCSQRTRDARCGQSAPLLRKELQRHLQPLGLYRDLDDERPGGVGIYFISHVGGHKYSANMMVYRRPDAFGLDAAERAKQQQAGGDEALVPKKADIEEGEDVGAAQCIWLARVKPEDCEGIVKFTVLQGKVIKPERQLRGGFDRSKGLLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW08</accession>
    <name>A0AAE0TW08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_476015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW08"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20434" checksum="1A474B78390F3E52" modified="2024-05-29" version="1">MNLSRDPASNPDSEKGLPVSIAASHLDGLVLALTPNSHSYNYRSAVLFGHAQLVTELDEKLYAMQLVTDGVVPGRWNGSRVPPNAAEMSSTSVLRVRIATGSAKIRSGPPGDDRGDLEDTALLGRVWTGVVPVYTTLGEPIPGPYNKVAAPPAYLEEYRTETNADVKGYAVEAALKDLHAAKKVASEEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZE1</accession>
    <name>A0AAE0TZE1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZE1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042101663" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="16952" checksum="1F10E1245569C4EC" modified="2024-05-29" version="1">MLHSAKILWHVFMIGLCQRIAYFAGHLASNTRRDPQRYLTIFESPPSLELMINLPVFNLQSMLEKSAAACSLNQVLSEIFQHPFGLAAYRVSWATQTCKFNLRAMSASRYDGELPRKIQDILDPSSSLPVGLSSLFGVTAFFASNNHLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0U8</accession>
    <name>A0AAE0U0U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_468445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="696" mass="75781" checksum="B9E9EA4812277749" modified="2024-05-29" version="1">MDPISIGASCLAVVSAAAKTTSLIRQFVRTYRNAHPDLARLNREISDLDLVLVSIQNVDSEGRLASAGVPKAMQDQLSALIRDCTRVLGEIQSVLTKSMALGRWDQAKWAMNGKEKIDEQVALLEGHRKALDLSMTTIDFSLSCNIKADTTALRVDAEENKDKLEEILNLLKLSPAAKTSPGGSDVARGKLDMMSRYLDSLSDYATSVYGGHTEVEEDKDEATVADSAARETQAAGKKKSGPPLENNDPKPGKADKKQGDKKQGDKRAPSQDPAPKPGSPDKKLTGKKLSARNQRHPDAHISLEAEEAHISGIAISKDGAKVACTMGNKLLTINASSGEILTKVHFTKHENTLRVALGILDKSELFPTKPSFVDRLGHRLAVEIPGLKEIEVWDVSGGQCWKERTYKKVHAKAAWTTSPYPPAPPGASLGNLRMAGMVLVEGFRDSRREVLGYQLTKSHRRPEAIWTAPLAITTNMYSELKRPPALLGTSGNGRRVFRALITTENPHDNLTAVVLLAEANARTQTWDTHTWPITKSWSLASRLYGESLVVNEEGTRVGVIWNDSGSQFKTEWHIWVNTFTGDLAQLYAGTVSSVLDMGNESVCALSPSCKLFASTPPSSAGNGDRLICITGITLGDGDSVSMDLLELDRLDFVGERGEGRVEHLEFSSCSRKLVAASKYALCIWDLSKKSWFKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1A3</accession>
    <name>A0AAE0U1A3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_153398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1A3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="253" mass="29327" checksum="CC4F6DF8D2D28869" modified="2024-05-29" version="1">MTSVFEPSLSTSRQPTGLSMADTLPSINFGFDDLRDRMAKFTAKFDVFIEQGRKRVLEERNQFRMNVTELQEDQRMKKKDIEILQLKTSTYQQTMAKEAAETREMQAAIATLSAQRDKQAATRDALREQIAATQKEIDARLAAQRAHAAQMEAQARFNVPELDFWVTNLCLRIDGAGAEDRLKFVYTHVDEKNWEREAWFELSTGSMDYDVRHCRPKLEKEKVERVLERVNETRELAVLLKGMRELFIEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U203</accession>
    <name>A0AAE0U203_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H63DRAFT_392893</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U203"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9 18" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042227816" description="Peptidase A1 domain-containing protein" evidence="21">
        <location>
            <begin position="19"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1075"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1130"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="22">
        <location>
            <begin position="140"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="557"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="171"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3387654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1165" mass="125539" checksum="6BC4FF30CBD14A9E" modified="2024-05-29" version="1">MLRVTLLLLTLWASTIHAFFPWKPQCDPSDTECVGNKWPTKETVHNAKREPLAAEGVTFELMQRRTPNVSARAARTAWEAARLSVKYAPAEAPHVSHSEEEQEHHLDLLKRENTFKFSTPAPPTGVHSTGIYQDGTDFSYFIQVNFGTPPKPLFMLLDSGASSTWVYESSCQTEACKNHNSFDPASSKTYKVENRNETIPYGKGSVQSHRGRDTVSVAGMSIDMSFGLVTNASDIFQYFAFDGIVGLSMVPSNASENFIQVLKAHQLLTSHMFSVSLNRNADGPNTGQISFGSIDPSKYTGEISYTPTVRNASGEWAIPLDAVTYGGKAANIPKTRLAYLDTGTTFIFGPPSDVRALHELIPGATTEDKGVNWKVPCNTTGTFALTFSGITYEIDPRDWMPGKGGKDAMCVSNIYGDEVIQNAWLFGDVFLKNVFTVFDADEYRIGLAKTPPPPQLVSSTATTVAGQQPATTGMIAPSPANASSGSSSVAAESSPSPSPTVISPAEQLESNKYVSILCIVGIIAMRRVGKYIYDTLMGGSRNEKKRRVELRANRYCSCPYDTTDPTSRQHAKSGERCSQAARMARARSHGAAAAAASTRNTTNNSTTDTTSPSQNEEDVGLLSGGAQDHNDDGDHEDDSGASGGGLIAPEPTPRTPRTPRTPNRVRFDLNPTIVGSGPERGGGGDYFAARESFDVDDEDPLNPGSTTATGRRRRREGQQRVPLLTDIEAPSVALANSPWDEGGEDGDDVHDWAARERARPKSGLRMAFMNMANSIIGAGIIGQPYAFRQAGLLAGVVLLVVLTVVVDWTICLIVVNSKLSGASSFQGTVEKCFGRPGLIAISIAQWAFAFGGMVAFGVIVGDSIPHVLMAIWPGLKDMTVLGLLANRRVVIVVFTLGISFPLTLYRDIAKLAKASTLALISMGIIVVTVIVQGALVPSEDRGSLNTFNLLVINDGIFQAIGVISFAFVCHHNSLLIYGSLETPTIDRFSKVTHYSTAISMVACLLMALSGFLTFGDKTLGNVLNNFPADNTMVNIARLCFGLNMLTTLPLEGFVCREVMMNYYFPGKPFNMKLHIIFSTALVVSAMTISLFTCDLGTVFELVGATSAAAMAYILPPLCYIKLTTRSWKTYVAWGVVVFGCAVMGISIVQAIAKMVRGDGGTAQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U248</accession>
    <name>A0AAE0U248_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_509534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U248"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="234" mass="26018" checksum="7ECDD4EBAC597844" modified="2024-05-29" version="1">MEHSDIAGQHELDQGQIQPGGGRSFITKAPIKPQVEARALIESNFCEKATGPNIKDKVTKEFQEKGRVIKPERAIALFTDAKLRGSVTVVDLRSGDEAGDKARWNLRIPGAKSHPIPEKAENMDDPRRLRAGMHPTLTDTDIKRNWAAQLGDQHSIWASVLEKPVVIFHCRQSANRTPGIANNYLNYVAGTRNPAPQLVLILDGGFDAYLTAVDDYLKVDKNKNNRPLILEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U253</accession>
    <name>A0AAE0U253_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_542289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U253"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="261" mass="29608" checksum="7A4EDD6A937BC6DE" modified="2024-05-29" version="1">MKVQLERPSFNDETYHVRCDLQTLREACGCLLDTTNAPNGSFIYENPDSPATILAHYTIREFLESDCISAENSYYKITPNDPAPKEEFGRLFILCATDLQRDVVSSWESEDKLLLLDLATRLLVSEKEWIELDVACGFFDVSKHAKRPNFAALVDASDIMCSWAYELYRPFQVVWSSVQTISDAAFRLLNLLEADLRGLAGRYIQSLRILDCINGVITLEARSHSHKDGLRSYGPLLELKTTKAHAGSFPKSTYHARLKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3P3</accession>
    <name>A0AAE0U3P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_518940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3P3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042014695" evidence="2">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="427" mass="44145" checksum="41FBE2A29CB26960" modified="2024-05-29" version="1">MTKITNIILLAAAAAMSATALPNPMQNADSGLVEARNPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRNVFDEQLVEARDPSQPNRPAPPIPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRNVAEDPALEAREPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRSVDTRAIKPELPRPQPKPRPVPPPGVPSRGKRSVQDETLEVRDPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRNVDDLIEARDPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRNVDDLVEARDPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRNVDARDPSQPQRPAPAPPGGPVKDIGGKQGDNGPGTPVSKKSRKGKRAVSYEEDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U406</accession>
    <name>A0AAE0U406_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_537833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U406"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="49711" checksum="7166BD7F6CB57C1B" modified="2024-05-29" version="1">MHRLHVVEEVEEEEGQASTGDSSPWIKLGRDERPFWALDRATSTPKWFHLPGRAKSLMVGLLSVGTCVGSLLGSDVAGYLGRKTALLIGCVVFTLGIVDQIASVNMDLLGRGRFETGLGMGTISTVIILYMSEISPAPIRGFVVAFYQFCMTLGLLIAACANYGTRAIWNMTSFRIPISLQLVWAVALVVGLVFLPESPRWYVKMGKLEMAQVALEKLRCRPKEDDMIHAELQNMVRNHEHEMEMVNHRKEVDSATDTYWASWADCFRGPWRERSSNFGRTLLGSSIQMFQQVTGVNFIFYFGTAFLKEQGFDNVFVILVAMNAVSVASTIASFYLVTKLRRRHSCVPARRRRRGQYWRATAGSKANNFGDMPPWHFWTIISGIGVYLFCYATTWGPGAWVLMGEIFPLQIRARGVGLSTATNWLWNTIICFITPVMVEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U451</accession>
    <name>A0AAE0U451_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_492734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U451"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="555" mass="61421" checksum="6D97FD5258E306D6" modified="2024-05-29" version="1">MAEKPSALSRFAEKIAVDAEPGLTTAQLMLTNHDLKPVEPARRQWGPWNFVGFWVADSFNINTWMISSSMIVSGLSWWQSWLCVWIGYSISACFICLTGRIGAQYHIGFPVVARSSFGIWGSLWPIFNRAAMACVWYGVQSYIGGHCVYLMIRSIWKSWDRGTIPNTFSADSGTTTADFVSFFLFWFCSLPAIWFPVHKIRHLFTVKAYFVPCAGVAFLIWAVVRAGGVGPIVRQPATAEGSDLAWKFVKGVMSSIANFATLIVNDPDFSRFAGKPKDALWSQLFTIPTGFAVTSFIGIIVSSSSTIIYGGDPIWDPLVLLERFIDDGGSGQRFGVFVIASAFALAQLGTNIAANSVSAGTDMTALMPRFLNIRRGGYICAAVGLAMCPYNLLTSTNQFTTYLSAYSVFLSSIAGVMISDYYFVRRGYLEVKELYDGRETGPYYYNFGIHWRAYVAYIAGILINIVGFVGAIGRDVPIGATYIYNVNFFAGFIVSSGTYWGLCKLSPIPACSDTWMEVGDEIDDLRVAYDNQSGSQEFEEDRGYNAYKHDDTKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U471</accession>
    <name>A0AAE0U471_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U471"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="218" mass="23105" checksum="7621A842C5D7B177" modified="2024-05-29" version="1">MNQSAPELKETIVSAAHGHAAVSDTANPVSISHYARGAVVKPPSLLPSPSDRPFSAGRLHFALPTLRSPREEAPGEGALSGHALVSSSLEIMVAPHSGQPDDDGDLQHGDQESTAASELPLHRPTKVVAVDLYAGRELLRSWGKGPDGQPPQPPLPADRNFRLHIMSDIYGEARGWLNDTIGGLGVTLTVEFRGETPAIMVSLVALIQTLRLARFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U494</accession>
    <name>A0AAE0U494_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_464693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U494"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31810" checksum="8093291BB6D43055" modified="2024-05-29" version="1">MTWELTRRRWIRTLNTKFIYGRVPLLHTIILLIEMALFARLTSRFNGYYDKRPVLTMMVTNAVLGGIADTVAQSITSIRQRALRKYPSGQSPNPRDDPLAYEIHELDRKNPLNERDLVPDSKVLPPPFDFERLTRFMAYGFLMAPIQFRWFKFLEKTFPITKASAFVPAMKRVAFDQLIFAPVGIAAFFTAMTLAEGGDRRAVANKLRDMYVPTIKANYMVWPAVQVINFRLMPVQFQLPFVSTVGIAWTAYLSLTNAAEDAMEHKRIDDRPVRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4F0</accession>
    <name>A0AAE0U4F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_446530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="204" mass="22623" checksum="7EF6947AA3BE8D5F" modified="2024-05-29" version="1">MSSNRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFANVEQHATEGVNKILIGNKCDWEEKRAVSKERGQELADELGIPFLEVSAKTNQNIEEAFYSLAADIKKRIIDTSKSEPAAGAAVNVGDQSGSGAGSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4Z6</accession>
    <name>A0AAE0U4Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_557894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3391027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="527" mass="57893" checksum="58AE0EC392C3B168" modified="2024-05-29" version="1">MAFVARLKPQACAFGRWPTIIRASTSCITFSQPQRGLSSSPVLRNEHTFRIAVVGSGPAGFYTAYRTMSRIQGAKVDMYESLPVPFGLVRFGVAPDHPEVKNCQEKFEEVASSPDFTFIGNVSVGSPSNHPDGATVSLASILRHYHAIVFAYGACMDRALGIPGESSLKGIYSAREFVGWYNGLPEHADLAPDLTQGDEAIVIGQGNVAMDVTRMLLEDVDALRKSDIAEHALEALAKSKVKRVHVVGRRGPMQAAFTIKEVRELMRLPDVAFHPVDQTLIPEDLKQLLRAPRRLMDILVRESSQPSPETYAKSWSLDFCLNPKKFGASLNDPSRVGHTEFERTSLSSPFDPNAYALGTGETVQIPSSLVFKSIGYKSAPLHEFSDIGIPFDERRGVISNDGHGRVSREQRTKDATMSYGHFPGLYCAGWVKRGPTGVIASTMEDAFATADAIAKDWASDGPFLRGKEGAASGWEGVQRETGVDKAHIVNWEDWRRIDGAEKEKGKLVGKEREKLTRTADMLAVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U566</accession>
    <name>A0AAE0U566_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 18kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_493130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U566"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3391015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="301" mass="34434" checksum="77C88D2AA00533CA" modified="2024-05-29" version="1">MYVSGETGEPSVETTGIIEDIVRQQVVEILRSSTELAARRGSRAITINDLIFQIRDDAPKVSRLRTFLSWKDVRKNVKDSDDKGGDADLGAGEDPVGGVVPGGPVEDTTKKNKKAKVGLLWDPTSFYGVEVPEREDEDDEEEEEMNYITLQRLRKADERTKVMTREEYVTWSEYRQASFTYRKGKRFREWAGFGQVTDSRPSDDIVDILGFLTFEMVQTLTEEALKIKDHEDLLKERTGESAGAKKRKLAQGLFDPPSEGRTPVEPRHIHEAFRRLQNRPKKLRAMLNHTRIQQHTPLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6X4</accession>
    <name>A0AAE0U6X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_516441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6X4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20674" checksum="86A2A670F299892F" modified="2024-05-29" version="1">MTEVELKEFGLGGNIELVVGRSGAQKKFRVHADILSAASPVFGRMLGPHFLEGRLLRRDGHVQIPLPDDRVEALEEAASVCHQIAVVADKWDFVAGIPEGIVRNWLAGVREMLEHHASFHRECFRLVLAADLSSMPKEFALAAKMLIFNAPSSFVQLGRDHARDNDPHDIVWPLTGIERTTATNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7I2</accession>
    <name>A0AAE0U7I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Necrosis inducing protein (NPP1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042211325" description="Necrosis inducing protein (NPP1)" evidence="1">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31197" checksum="52B6997BA61C46E9" modified="2024-05-29" version="1">MPSLRSAAGACLLLLGLTAMAVTPVSDSAMTDLLNAGGVDLAYAAAPMWFFGQAMNQPPCYPTNATNAQGAQTPSAALCNWPNTGCNCRNPGVPITNAGPPFPVYYSYNRCAQTEVRIAYNLFYEKDGFNPDQIFGHRYDWERVIVIWAQQPDATWIPSKIMLSQHSGYQTLNWGDIQNTFNTGDAGLPRGGDNGLQNRDHAKVYVAWSKHANYNTRNTGWNDALSQLTDNAFRSQDWWYFPKKNDYLRADRSTPLGATIASYNWGNADSYPAKVHDGLCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8V6</accession>
    <name>A0AAE0U8V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_408742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3395301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="351" mass="38699" checksum="7917CDA209ECBF48" modified="2024-05-29" version="1">MSESSREPSPMDAESRFTEILAILAVTGTLSSLVIAMRCYARISLLRFFGLDDGVMLAAQVLNLAATAVVGLEAHFGLGRHAWTMPEENYIPYMKSFYFSIIFYNLGMCLTKISILLQFRRIFSAVTMQTATLYGLYFLIAWGITLSCLLPLVCYPVRAFWDTSVSGRCLDQSAIWYVMAGVNLVSDFALVTMPLPAISSLKLPKQQKILLFFVFTIGIFPCAVSIYRIKTLRVAAVSQDPTWDNVNAATFSVLELSIGVIAACLPTLRPIIITYMPTLFGTTLRSTTPATGRGTIRIRNTVTVRHSMGDMPAKGHGRYLSIGYGTDKMEGKTTEKVLEAPMNLSRGGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JY79</accession>
    <name>A0AAE0JY79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JY79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="25210" checksum="76E97A727845D650" modified="2024-05-29" version="1">MDDCRRFQLPSCLRVVADKVIELKKTLYGLKQAGFNSQEKLVTKVILGSFVSDFLIFVPTEKGVDNFKLQTSQQRTIQDLGEAEWILRYFSGFTQPGIRVAYCKAVRQIAAKHPDTVKLVDLWKVFMDTAIAMMPGLRPQQRGRGPGRHRRRRARVHEGAAARRPAMVRETMSTYINRRPLGYDTTQQMPDLIHQRGQRRGQLLNVWEAMNSNVEPRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYS7</accession>
    <name>A0AAE0JYS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_90737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYS7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="759" mass="85724" checksum="8E834C1598412965" modified="2024-05-29" version="1">MSLSNRYAPLFLISLGNSGTIYGRYKELGLEIYELLDPDGKLKKVNLRVAEKTTKLLVEKLPAEDRTKASSKLEQAIALRKEWGERFKFAPRWKQNNHRKYIDFLTGILEQITAYTDYTAAVVDAKEPPREEDEAADDDGDDDDDESNLTPAQTDFLAFLDDVMAMARRAAELWDEVAKGTLPPWTASVLSGIILREIDILICRTELLSDRNSGPSPWAATEGGDHSSPQLAQDWVKALDEACGEGTTWHELAKVVPNIDPCFMSVIGLCVQYAPKLEMNSSWFPYAFKMLRPATKALMKYPNPSTAQVPLVTLIGVYFYCLVTKHKDATSNTVDLAAARKATCAAIDENLSLLVRMLHLKNIDKEQMDEIRQQAGEMKGWAMNCVEQVSLGAIHAYAEFRRVHWQTRITASDSLPLQIILYLYEKQRLQDPKNTTGGDDERLVGALLEDPRIALFMLQDGRPKSVSDCITALRNWCHVQTSNGETIDRNRSWSPVHKRPEYSFKVRQSDLWCEQIINNGYAITNTMYGDLKKWNNGPADGDTLRSYLIFEMNAPSCLELEGAFFRAVSSRPGWQELCRDAVLQKLSQEDQWRRKVRSLVVDVLDTTPALQENSNSCIVNITKLETAVTEAALKVSGYQNSFKEAFTSFGQTLVDWQDSVVDKLVRGAWELSNSSNIEGIVRSPTTRAVAAIRYMLPVDDDNNKDTRQKEEVSETRKRVIRQLLVDFMKEARPILEKIYGRKPGETTDGIETMVGRMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0D8</accession>
    <name>A0AAE0K0D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_423805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0D8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="560" mass="59196" checksum="CF198936741670A5" modified="2024-05-29" version="1">MATSLAAACVPATFGNLALFGAEILSLQTNLVTNFSASVPGVFRFTQPSTELKEATFCNVTVTYTHPGQNDNIIVEAWLPASEDDWNSRFLAVGGGGFVAGRFVLSYANMQGALADGYATITTDAGLGSTNEPSSWALLSPGNVNPFNLQNIAYVSLNDEAIIGKSLIKSYYGKPPSYSYWNGCSQGGRQGMMLAQRYPTAYDGISAAAPAIFWTELFTTVAWTQHVMKNVLGAFPHMCELDAITNAAIAACDALDGVVDSIVAETDACLATFDPFQLVGAAVPYCRDAVNGETVSVTRAAAAVANASWHGITSPDGTKQLWYGFNPGANLTNVISDPRTGATGLGPAATNCTSGSCVGLPNGLALPWWNLFIARGDPGLAFNAINTTAEFDSMMHLSKQLYSHINTDDADLTEFRDAGGKIVSFHGLADTTIPPNGTRHYFNSVAAKVSNIDTFYRHYEIPGMGHCFGGPTGQPSSLFEQLRAWVENGTAPGSTPIQVTNLDGKLEDRILCPYPQKARLLGSDSGVVGGAGYGNSTTCSQKKWVCVDSTDGLNASIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0Y7</accession>
    <name>A0AAE0K0Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_515655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0Y7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="22783" checksum="75F407C451212CD8" modified="2024-05-29" version="1">MDCWRVGPSLLRDSPKHTPSPFTVTVTVTVTVTVTVTGIRTIASVVSRMSTGTGTSTSTCTCTCTGTGSVSIGHHVRLRLVADKTSQWLIGIEAQTLLRPNYFGLHYQGYKKRGRSLAALLGSELTRASSNDERVDDLVTCPTSVASPVSFRPAPALQRPTSARYNLVPRPNHCSLGFVAFSPDGMTLASICGDNTVRVWDVKTGSLIQTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0Y8</accession>
    <name>A0AAE0K0Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_515384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0Y8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="283" mass="32049" checksum="30C7A4004C975072" modified="2024-05-29" version="1">MATNGTTPVATTDCLGEHTPRFSVLLRLKPGRLPQPEWTKADGYYRLLSWEDSTFKHLFYTLPHDENACSDFLASGGPCPADIPRVKLNRHYSTQNFMTDPQREGWDKYVFHTGYAMANYDPNRRGLGANREDRRRLDRQFDREENLRRFGAENAMIATNDGFCPRRPQTCSPSDERNGYLLREFEKARDVAEIYAAIHDRGNGITPRLLAYLVETNGFCDRIIGLAVEVVENTRFATPDDADACRAVIEKLHEYGIVYGPSMRCSSFLIVEDKAAAAAGQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K179</accession>
    <name>A0AAE0K179_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">B0H63DRAFT_534258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K179"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="113"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="51634" checksum="7A61B4FF55065339" modified="2024-05-29" version="1">MSTSLATDNAIGRAQELDKNDAIAFTRSEFNIPTTAQIASTRLPSESSEACPSSDKECVYLCGNSLGLQPKRTPARIGQYLATWATQGVQGHFKPLEDSPLPTWLDADAKAAQLMAPIVGAAESEVAVMQTLTANLHLLMSAFYHPDINGRHKIILESRAFPSDHFAVETQLRHHGLSPDTSMVTVKSPFSEDNVLSSYDIMSVISTHAADTALILLPGIQYYTGQLLDIPVINAFAHKHGIFVIWDLAHAVGNVPLSLHDWDVDAAAWCSYKYLNAGPGSIGGLFVHERNSLVTKAITDDCPEEGYSNRLAGWWGNDKRTRFAMANKFHPVGGAAGFQLSNPSILDITSLCASLEVFALAGGLSALRNKSLAITAFLEDLLLNSMTDQDKALFRIITPSDPDQRGAQLSLLLLQDGLLETVMKELEARAVIVDERKPDVIRVAPAPLYNTFEDCVKFVDAFSLALQAARAVKGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1H0</accession>
    <name>A0AAE0K1H0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside Hydrolase Family 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042055487" description="Glycoside Hydrolase Family 16" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23792" checksum="23145989E27170FD" modified="2024-05-29" version="1">MTPSWFVAVMATITMGTVARAAALPSKQMESSLTPRNSFTINEVELQGEPDYTKAQVTVNGTSKVLDLTTPDVRIEDGIIIKPLGPGAFVNASNTPLHLFPEEEIHARARLESRDPDYHCSMWFYCYNSYINIPRGYGLWSWYTIRQNQGESNDGWSGLMVTSPGSTYNAYGPEGQGFSFVDVAYGCRMNVYSYYCTFDIYGKLGSYNHFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5D5</accession>
    <name>A0AAE0K5D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5D5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="297"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="456" mass="51086" checksum="E2681FAE0334D81C" modified="2024-05-29" version="1">MEHDTGRKAEILDKSVWHSLEDLGDEKCQGTQEDRFMQLGDLLNARTCTSVLEDEPLCSKNTGNDDHDGGPRATIRSHDAPVVSQAKDHLVLKVSLFDTRAKARPPRTSRLSLLQQMFDSFVNRLLAYNYSTHIGLITFSTKARTAQPLTHVIENFRSTVQNIMVDSFCLGGTDNLDLRTLSAITNGFKFHPASLNQAFAICEMEPVLSLLERDVAVIKTSRSRRGGNSTSRISGVDAPFYMAQSHATPEVVTRDEFPKRKQHPLVESSFVELKAVSRQDLTRNRADGNTLTSASVLCTYRIMNEMQQIVANPHPHIDVYVSEAEMSFWKVVIQGPPDSVYESGTFVVYLDMGEEYPALAPKARFLTPVYHPNVNRHGRICHSLFDRNWSKDTTNSMVISTIYRLLLAPDYSDPINVLVTLDFHHDHIRGYGEGVHPKACHQDTGRVATRDSGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5Q9</accession>
    <name>A0AAE0K5Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_315385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5Q9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49656" checksum="BDC77614B57BEFB8" modified="2024-05-29" version="1">MEQGKPRGPGDNGDQRKDGEDNNNSNTNNSGKPPKRKAEVHQRWEQPLSCPFRKRNRQRFNYRLHKSCTNPFKDVQAVKAHVRNWHKLSVEQSSHQCPRCWETFSSKKGLTQHASHPVDQICEPREQPVNNNEPEDGITDKTSNSLVARKGKDKVSSWDDMWNLLFPDDINVPSPDHEPSGIAEVFEYSQVFDELLAHESVVTGLPENMRSVLKGIMDEKLGCLEQRVLLESAASASGRGRSGTATSGNVPERSQSQGPGNIGSFEPPSLQISYATPQRHRQTARHAKRQSISSPKAIAPKVNTSFRNQSSSFYHPGSGSLSAPMTPSPHSGSSMSSFQSIHSLPSLWGDHGVSPTVGDPSALQPPAMPSYSSQPTGFVTNQLQGGQPVMYPGDNPHFPSYYAAPHAAGAGSGGVMAAEAFPNQLGGYHSTLGSWEDLTSSHSLPGPMQPPDQGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5S0</accession>
    <name>A0AAE0K5S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_486319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5S0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="359" mass="39582" checksum="FD4E70FCF387FA2E" modified="2024-05-29" version="1">MRFKTDLKNIRTLSKLAAALNSLEKIAWVRLDDDSVRFTVIPDTGSQVWATLSVDLIFDGYHIQSAEPNNTINLELPLGPLQRALKSATGSNHANLRLTKRDGVPMLSMTIHTMTKDAQQDARGGGQFGGGGGGAGRSYHHGQDFGNDPDPFGDAGDVFQQESLELSLKREREKVITQDIPVRVLHPDTVETIMQPKVREPDVHIQLPPLLQLKAISDRFTKLALTTATSNRGTGSQNPKLELSANMHGSLRLRLVTETLDITSVWENLDNPLLDQSQLTVPLAEHPSTIFEAAGPNKWATVRVDGKDWSRVLSVGRLDGRVIACFADDHALILYVYVPNFDDISSEDVITYYVSSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K605</accession>
    <name>A0AAE0K605_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_313370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K605"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="16038" checksum="0F1A391914E212E7" modified="2024-05-29" version="1">MDDDTTFCMALRCVCSSFLFLFLVLVFLLLYRSYWCGWRGRGKGRGNVRTTTRIVVLFLASTKRTYDIITDNQTTYYYYHYLLLPITTIIHISFPLFFLFISHYICHFRASSASMYRWFSGQAFFTMTAHFSRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6Y2</accession>
    <name>A0AAE0K6Y2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6Y2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="204" mass="22574" checksum="FF5222E8EEC8AAF4" modified="2024-05-29" version="1">MAAMATDPLCPGRRVHRRTISFEYECVYGQLKIRTPDPSTRRAAAARVNICLCSEDLDSGNGPLTLARGFLDWHNIPPRPSPIPGDHTAVFVDMGNHNLRATTTNQLKIHVSYDPKKHSESIYRQRTLPEQLAPGLTRGWFTQISAIGHGCYGIQSHPEATPVVPAGWERMANEDPEAFMDATCEPGRNQDGVVVEDDARSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA64</accession>
    <name>A0AAE0KA64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_420775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA64"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF6">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042205710" evidence="5">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="30"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="313" mass="35040" checksum="1AA6F460CC355E2B" modified="2024-05-29" version="1">MYLSGGVVVSLLSGACLGVTPSKPLLWRRTPCSNLNVLPMNTGMRGNNGIYWGWNPDIEKGDNISAINMMTGRKASTVGIFSQINSPNGFDGHQLLRHLDEVKGSGAALIASVMPNGLSFNEVTPKIAEDIAKVVRQFTDQGVEVWLRFAHEMNYYVRPGTYRGNSTQFIKAWRTIHNATKDIDGCLLFWCPNNAKLIDLMAEWWPGAEHVDIVGMDQYPSSLSATFKSTYGAFYDAYAKKYNKHMAIPETATKPDNATLKQAWVRALASADVRAEFPCLQSVTWFELHKSWDYRVVMGQDKSVRDRTLSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDJ6</accession>
    <name>A0AAE0KDJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_480832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDJ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="140" mass="15532" checksum="6280EAA2FC8D5C61" modified="2024-05-29" version="1">METYPVTESQHLPPAALRHIALAGPLDEICNAPGSVRHHLFWHGWRDKETNKLGKSMLFFIYQTGRHGPQNGFRLCVVHQGYHVTSPTKDESDAGKEDDIDRVERPIAQGLMEVVVLGEVPAWAAEEDDAGGVEFVDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDM8</accession>
    <name>A0AAE0KDM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_260571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="481"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="580" mass="63588" checksum="2AF89319FB441A67" modified="2024-05-29" version="1">MSGAPSRLRNVLGHLLSRSATEQPPHHISQLSPTYFLERAAAIEPNAEAVYHVTANGKVLRRSYMELADRARGLAYYLRKKSLKRVGLLAPNTPAFLESVYGIVAAGAIIVPVNIRLKPEDISYIFDFGEVDSIIVDAEYVDLVDAYRKGHPHIPVIIDLDTDATEGALCGPFDEAVLEGLNEDRQTGSKGWADLVSQTVANEDDMIAIPFTSGTTSKPKGVVYTHRGAYLATLANIVESGLNLPSGRCKYLWTLPMFHAVGWTFPWAVCAVRGTHVCLRKIDYPLIWQLLKEEGITHFNAAPTVNTLLCAAKEAVALPHPVRVTVAASPPTAHLFEQMMGLNLIPVHVYGLTETYGPITRGYVLPEWDSLPKHDQYAKMARQGHGFLTSLPARVIKLDQPEDVLIDVARDGKEIGEIVFNGNICAKGYYKDPEATRKLFAGGALHSGDLAVVHPDGSIQIQDRAKDIIISGGENISSVALEAMLVEHPDVLEAGVVAVPDSHWGERPKAYLTVKADVKGALQPQDVIDWAKHQSSISKFMVPREVEIVHELPKTSTGKIKKNVLREWAKKGTPEGQWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEK9</accession>
    <name>A0AAE0KEK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_549033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEK9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="385" mass="39796" checksum="218829FF4B6A2D77" modified="2024-05-29" version="1">MGVPDHYSQLPEAVEHNPPEVVTPAFIRAPEVVPLQDMNKDTWTMAGGGHSAHSSPSPGWAIPYPQQYQQQQQQPHDGLQHHQHQQMQYAAGWGSNDRPPQTSNYAHHDNAFLTSSHMPKTPAGGTEAAGSRKLTIWILSILVGIFAAAVIALAVVTGEMSKRASAAENTAAQAQLGICTSLGASCSDANVNAKGDGGLVSGSSGARTAITTVTVKATVSGGTMPTKETGAADTCPSIAASVATAPAATFNTVVIQDQSNGCGEKDEKISGTNFVAKLFGKVKFEMYCNSALGTTNSNAFAGLMAQDFEACMNACAGWTFANSASGNSANGTCAGVNYVPAYSNKTLVLAKNARGNCYLKGGPENKGGIKAPDGGYNSHAAFVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KES0</accession>
    <name>A0AAE0KES0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle control protein cwf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_269419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KES0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="148" mass="16931" checksum="7F94FAA4B28658B4" modified="2024-05-29" version="1">MPAIRAASKRKPPPEGFSDIEEDLLVFSNKMKDAQNTPTDNIPKHQAQWPIFQISHQRSRYIYELYYKTEAISKTLYDWLLKNGYADAMLIAKWKKSGYEQLCCLRCVQTKETNFNSTCICRVPKADVKEGHEIQCISCGCRGCATGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEV9</accession>
    <name>A0AAE0KEV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_481295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEV9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="60366" checksum="1C8D0FC4E99FB844" modified="2024-05-29" version="1">MHHRLVAMTEFSSNPPAKLPSSPGAANSTSVDTESSAAPPGYHAFRRSFHADDAPSFAARRRPISGQFSVTDSPLDDLRRRSSTFSDYSFSETMNHLEDSIYPSGAMLEGNDKSLWQAYPVIVIVLPAVVGIMFKNGANTTTDIMLLGVIGVILFYSVTLPWSWYQSAQQVRLEEEIMAGFDEDVTHGNAHIHQAAEPLVSPSSPKPKIPILKDMPEEQAAASSSSQGPSGNGNACAQAQRESVRKAMRELYVYEVIALSSCFAVPMVVAWLLHWFRSSLTNESSQVWLSQTNVMIFTIAALMRPIKHSVALIMHRTLHLQRVVHSNPYRTEVVTPTQFLELLQRVEELEAARASVEDATPRQRQQQQNGPSADLQRKARQQQEAIMAQKVRNEIQPELDTLSRAMRRYEKKSVVQASQTRSQIGAINARVDDAIRLAAAVASTKSSPHWGLFFGRMVDRLVAWLLFPLRIFLNLVTFPVTTISGVLRGGGRKRKPVQEKTANGYCDRKGSVSPFNSGKGSPMRPAMPSPLGPDRVNQRFWMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEZ0</accession>
    <name>A0AAE0KEZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_548970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="308"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3374690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146085" checksum="3F4B10E23F996F8B" modified="2024-05-29" version="1">MATPPDPSVQVLQDALADFQAGLSAEDRTQLQSLKEKPDVDACIKWTASLDRMDRNRRGASIATRVYSFLQSVQQFSAIIDTFVQSDPIIAALVWGSVKFTMMVVMNYTSYFDHMSSALRDFDRWSPRIADYQLLFPTSSRLRMAVCRYYASIIAACKRIAIIARRPWQQQLAKAMFSSFHTEMKAIVAEMQVNARELKYDIALAKAQADAEEHNLQKKERRAAADQRQALVPFVASASTAIEEARTWRKNIDKQRTGQQRRDLLDVLSTFDCMSAFKQARRKRYQGTGSWLAETPAFQSWKESQANSVLWLSGKIGSGKTVLTASTIDHLFIQRQPDESVLFVLPNFSDACSLDAETILRSLARQSLDADNLSEQFASIILRAKDSMWSTDDLTQLLKVKLSTFRQTFVVLDALDEIDAPDRRTILGVFSKLVQSNGGLVKILLTSRSSMKTEITRAFPATLQLTMDVPVAHAELAAYTKAVVDERLETGDLCVSNHDLIHEIVAELSAGAQGMFLWVSLEIEDICSQTCDEDIKHALQNLPKTLADTFSRTLHRIISRGKADVCQKAFAWVLGSYRPLLLEELGEAIPIEIGQKYTRPEKAINAIDRLPSWCENLIQVDEDTSQVRFIHHTVRMYLLDTSHATLGYDIPARRFHGNLDEFQNMVGNLCITYLNFNDFKTTLSETSSQAVKLVKMPEPKHLAKHALASSLIPSMAVRLATSSPGHKSDTSGADVNTTARAINIAGAFTRASDSLDSLAESHPLLRYASKFWLQHTAPLRRSRHTYPLWMQMIEGSHGLAKTPWTAHEFASGDQKIIDWGLKHKNWALLRYVLVTRDIQQLSFARGFGHALSKGHPAFNSTWSRRSHTFSILMHTSRPLLMNEWILCQKRSRGLADLLLDAITQEFMPSQSSSLISAASRLTEKAVHRIADKSVFSAGLYQTLENICAKGVTEEREMHAIALHVYIVRGMKEEAERILTENRDLAVLQYGERFTMELAIQHQTPDMVKLLLRHGADPNQIFHGQITKSDKSKQDEMMGEELSLDFVRGPYNRMGGHDASSSVQPVDDTDEPAAATRGPTALHVILYNLFNDQESWPDSIGMLKILLDAGASPNAQDNYGRTPLHLVLKLHTRMEDLRHVLELMQIIAGQKGTTRGIDFSICDDRGYTVLVMAMEASRPGMVGILLKLGADVNSQCRPTGLTALHVAARKCFPASVKELLQHGADPFLRGSDQKDAIGLAIQSWCRGQPGALDTLKVLLKHIQPANYTLVDREGVLVASLERKMSTRKMEAALMRCRSAMITTDKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KG04</accession>
    <name>A0AAE0KG04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_483112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KG04"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042205109" evidence="1">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="15163" checksum="670BF3A400FFDFFF" modified="2024-05-29" version="1" fragment="single">MLSTIGILLFTIATTAFAHPLDEAGKIAAWVNHPLVRPWEISCSHCSGPQTEKSCRHCYGGLISAGFCSYSFNVPCNTVVKFKCYRYNVQECNGNFLLSVLSSVDGANQICRRSRSHCSPRDLDFPISEGVRLQLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KGC4</accession>
    <name>A0AAE0KGC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_482540</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KGC4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="362"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="578"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="762"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3375305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="841" mass="94280" checksum="218A433C589E8075" modified="2024-05-29" version="1">MPPKRKAAPAAGGSAKAGRASALSTPGPATPRSLDSSMMSEADEDLDEDVTEAQKEREELLGQEADEFVNNWAISSKRFQNQPEGKKHDAATPYFGKRDFSGLPLKPDHLNRPLWIDPDKGTIVLERFNALAEQATDFLITIAEPKSRPTFLHEYALTTHSLYAAVSVGLRPRDIINTLDRFLKTALPTSIRNFIQQCTNSYGKVKLVLKNNKYFVESVDAEMLQKLLKDEVIGKLRVQGSGDITTTYAPTMGGLVIPGTKNAAGVHQADLKQADKQEEPGKEADLYASLNEEDDDDDKEAVHAFEISDSAVETVQKRCLDIGFPILEEYDFRNDDVNPNLEIDLQPNTQIRPYQEKSLSKMFGNGRAKSGIIVLPCGAGKTLVGITAACTIKKGIIVLCTSSMSVVQWRQEFLKWSNINPDDIAVFTAESKNKFSGSTGIIVTTYSMVTNNRERSHDSKKMMDFLKGREWGLMLLDEVHVVPAEVFRRVISSIKSHSKLGLTATLLREDDKISHLNFLIGPKLYEANWMELSQQGHIAKVQCAEVWCPMPTEFYDEYLRANSRMKRTLYAMNPRKFQACQYLINYHEARGDKIIVFSDELYSLKKYAETLQKFYIYGGTSQQERMTVLENFQHNPNVNTLFLSKIGDTSLDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSSKRQAFLVDQGYAFKVITQLANIEKTPNLAFATAQERRELLQLTLVDNEKGTEDDIETDDLFGKPGAGAGGRGKKKPGPGVRRTAGTLGELSGGQDMAYIEQNKGGAHLKKNQKANQSSFFKKIAREKERSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ38</accession>
    <name>A0AAE0KJ38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_477194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3377433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="70453" checksum="65C67DF95AF43965" modified="2024-05-29" version="1">MSFLSSSAVKRDTKGYGNISSNTSTCDPGLVDSLAAVLPKGYTFGVYHLSTPPTKTEPLCSAPPGERPDKTYAENHFLAVTVDYPTHGAPPTASKRASPGADEFKDTETSKKTVLAFAIEIFVFTTAYQTTFFVSKADSTGYLQLLNLPKGTPSPIREVASTFLTYLLEHRRRKNIQSVVNLFARAQAQYLFPGSVENKGKHVLDDWGLVKWWCRVLNPLLEGQKKEPWGQTKGYLIVPGLEESEMRAFLPRTPASATNWSIGHPMECISHYTAEFDWVPPRCLIPHYPDDPKSRFRDELDDESSKWKQDMGSWKSVKSLDQFWEMMAFRQECSSGRLTGFIWLVFDPKEAPRMSQETAPSSTPQLTTPNTSFDSSLPAPVNPPATPPRRRVDMSARTPQSSPLKLGLGSATSTPSQPRILPDDQQKKKKKKLKGHIVPRLPKVKTQQRSYIANRPSTTAYYYWPTQGRGNKVVDESDFKRIVELLLHLDFATLDKATAATRRWISEAAMGAKWGQEVTGKRVSLQNYSLKAPSGHVNNLGSSGLVRRMNDPPGPANPDGGKPTSISAPLQNISNRGVNVLGAGLVRKKKKVEEDTENVASSTTVQDNAPVRGLEDGADIPKVNALEAGLVRKKAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJT5</accession>
    <name>A0AAE0KJT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_477333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJT5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="53"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3377512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="405" mass="44849" checksum="7816AD6F9E8859FB" modified="2024-05-29" version="1">MSMMALPFDINDIPAMQPPPGVIPNFDNPESMHPYVLGVAIGTIAVMVIAISIRVYTKAFIMRDMKWEEYFAILAVAGMILWDGIFIHVSASGFSRHFWDVRLVDVHNMSYMSYLAEISNAITMFAAKLSILFQLKRLFCTGQSRDAIYWAIHGLMFLNTTYYLSALFTFTFQCTPREKAWNALTVEGECINVAAATLVAGAMNLFLDVGILVVPFGAICHLQLPMKRKVGISAVFGVGVLTCAIAAMGVVFRIPLLSTDPDLTWLVSKVSIWMMLEYCGTILVGCMPTFPRFFLHIRGKDPLSASHISSKSKSKNSNNPHTAGTKNTTTRSTTQLRNNKKADAVGLAVTTSEVSPPYEGLEGHQKTAPHGVRPPSSVYTSRTRDWEEGYDSDSDSQWFRLSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJU1</accession>
    <name>A0AAE0KJU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_221221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="288" mass="31504" checksum="0B711BAF6BD44064" modified="2024-05-29" version="1">MAGNGRNRRSQHTRATAPNQGGQGGPAAPRRGEANQQPGPNTGAAAPRREGNTGTNTGAAPRRETKLSGPKVGDRAPGFRGRQPRNLLPVLRPRPPPPRRYPTSSFQGRRPFEGTTSTTTGASPPLALDRYIRSVDDELFGRFAFPVEGEDEDGNDGRNRELKWRVDETAGQIQWARPPPPPSRGGTPQNNSSDHHLGMMKILKRGSSSLQEELEKEDVPNKGDVNRASPPSASKTEGTYQGSTRNRMTTFQLLGVGAQFEGQIENYELEEKMRLMTLSKYQSLPEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK60</accession>
    <name>A0AAE0KK60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_477959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK60"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="377"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3377777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="779" mass="84337" checksum="79336356F88579B2" modified="2024-05-29" version="1">MSSPGRDSPAPAPRGVPMASSPSPGSVHGRAPSYSMSMPRADSLARLASPIPYHALGTPASLRQSNRHGAGAETEPDNLIPLPGAGSFVAGPGVSALAAALSNSIGTSPPRFGTPPIRPLSPAASSALLPTSATPTNYGSFDARSRHVSQTGLTGLGAYEDPEIVKRHLVQPGDATPDDSGWRKPSVGSRKGKQPAEGAQSQSDDEEFSSLKLLGGDMTRPIYKWTEEIDQRSKVQRSKSFSVPRPEPENETLDINTIKVPGGFRRNFLRRAAGDGSADSDEVERGVGSSSAAKQPRLFTNSFLEFLSIYGHFAGEELEEDDEVLKPGEYFTSGSDEGEYSSGYEGSDDDREPMEDSTLLTPSKRKRRRKGRGGSGQNSPMSAALLLLKSFVGTGVLFLPRAYLNGGMLFSNVVLLGVAALSYYCFVLLVTTRLKVEGSFGDIGGILYGKWMRGLILTSIVISQIGFVAAYIVFTAENLQAFILAVTDCKTLISITSLIILQMVIFLPFSLLRDIEKLGFTALIADAFIVIGLAYLFHYDIITLSSEGLADIIMFNKKDWTLFIGTAIFTFEGIGLIIPIQESMKQPQKFPKVMFVVMIIITTLFIVMGAVSYAAYGSKTETVVLLNLPQDNKLVNGVQFLYSLAILLSTPLQIFPAIRITENALFTKSGKYNPYIKWQKNGFRFFVVALCALIAWGGADNLDKFVALVGNFACIPLVYIYPPMLHYRGVAKSALRRWSDVFLCIFGFIAMAYTTSLTVMSWANGSGEGLPSYCDKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKG5</accession>
    <name>A0AAE0KKG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_246921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKG5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="557" mass="61366" checksum="EAD77429E67A3F52" modified="2024-05-29" version="1">MRRTSVSLPTKHVAHDPFEKPDRYDFDYRAPGLRSRMQSAWANQTQNRMRYIKSGAIIFVVFLLFYFFSPSGVDLYHGVSGGGNHGQVPSDDSYGTKMCTKSFSKTKPIVQYVLMIDAGSTGSRIHVYKFNNCGPAPELDDKGEILFHMTPKIEGQSSGLSAYADDPEAAAKSLDVLLEEAIKYVPDKLKACSPIAVKATAGLRMIGTEKSDKILAAVRKRLETKYPFPVVSEAENGVAIMEGSDEGVYAWITTNYLLGKIGGPDHSPTAAVFDLGGGSTQIVFEPTFEGLTSGGMPDKLAPGDHHYELDFGGRKFALYQYSHLGYGLMEARKSIFALLVDDVYQQNKDQGQAWLSQPIVNPCFSSGMQKTVSVTMPDFHPLASKKGLELNMTGPSVPAPAQCRHLAERILQKDKKCEIAPCSFNGIYQPSIAKTFAKEDVYFLSFFTDRTAPLGMPESFTLREMNDLAHTVCSGKPAWDVFTSVPGALEELSDRPEHCMDLNFMLALTHTGYEMPIDREVKIAKKIKDNELGWCLGASLPLLAQGSGWKCKVTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2U4</accession>
    <name>A0AAE0N2U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_535115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2U4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="57490" checksum="96E17C6C6EA25088" modified="2024-05-29" version="1">MDLQSLVSKLRGSPVTLFVSVSFTSLLLYLLTSYVRSPLRQYPGPALAKYTNLWRLYHTMQGSWHLVIDQAHKKYGPVVRIGPNVLDVDYPSMLKTIFNVKAEWRKTESVSSSSVLIGGKVVFNIFSELDPAVHAQTKKPIAKFYSAGAVPALEPHMDKTINLLCSELEKRFMGGGSSAGKAVDLGEWISYYTWDVIGAITFSQPYGYLSKGTDFDGTIAGAESMLAYFSLCFSIPALDYFLSKNPIYQLGPAPFESLTGTTVQRLVARLQGLDKDHHDASQPDYLDKFIEVKAEDPANVTDGHIIAWLMINTLAGADTTAVATRSALYYSLKNPSIWSRLQNELSSAGLTSSHCPVAYKAVRGLPYLDGIVREALRILPGVSLGLERYVPPGGHNLPDGFVPENAILSFNPYVICRNKGSFGDDADEFKPERWLKRKDETEEGYAARLLVMNNADLSFGGGSRSCVGKHLGLTQVYKVVATLALMYDIELTNPEREWVVKDYWFPVQKGLVVDIKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3E8</accession>
    <name>A0AAE0N3E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_489181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="404" mass="46073" checksum="3C27D0A34448675B" modified="2024-05-29" version="1">MLMSDFSTSTTSTDNPRRCRVLGCRRSHVYATIGSQRVYSQFCIDHTCFKILPDTKAYHCPHPKLKEQKYCLSHRECGARGCREEGENDDDVLPWFCKAHRCTSSGCLEGIDNFLQKRCAKHTHCAAPHCTSPPAAHLHSTFCARHTCSSGACPNQARENKKNTSKQFCGDHECAVGGCGSERDSYGDFCSMHRCTLDNCLKPIVDLDRADSLFCFDHACKVAKCLRCCKKPSDYCDDHRCRKPSCPNLGANGVGSLCTAHRCRVADCEREGNMDRGFCASKHACIVPLCPKPRITDRIPTTGEMAERCIEHHLAWERAMVRRAVSEELTAEFEQERTEWRKDKKRLSDDINELRKRDQEKKEKEQHLRVDRDADRKRRASNEGHPSPDRLYPEYRGGWYNRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4A1</accession>
    <name>A0AAE0N4A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_311964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4A1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="210" mass="23139" checksum="23449BF74C912563" modified="2024-05-29" version="1">MPSCQNDTASCFSRSLLASFHRSFLASFPFPPSPSDVSPRSSRACFIPLLGRFKKSSGIWAINYASSSATPGRLTQHCTILLVGCRRTFPASAATPVYGLTASPDFPPPWELCQETDRAEESSMPCVCGCTCWRLIAMIPSPRRAAMSFDLALYRSPSTLLAIHSKFSFRLHETRGNCSIVVSVSHGRRIAVCHDGMITFDRLRWHSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5M0</accession>
    <name>A0AAE0N5M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="39781" checksum="F0BF0EC0DDE4F807" modified="2024-05-29" version="1">MSYYPPPPGASGGRQNYPPPPMSAPPTQTKFSYPAPPSASQTKNYPPPPQAAQSSSPPPKTASPAYPLPPQQQPQQFSAPPSALPSHVRNQSAASSQDPPQFSAPPTYPQDEPDIQHTEEKGHANQPDTTAAASLIAGAPVAGQFVGASAVVDDVGTFNGGSYRISHRDCNTILTVQLAIGCPLDARSGAMIAMSPSIVVKGAYKFSMKKLVAGGEMTQSTFTGPGELLLAPPMLGDITSLRLTGQESWSVSHDGYLASTQNVQKDYKRQGIGKAMFSGEGLWVYKISGVGLLWLTSFGAIIRKDLAEGEKYIVDNGHLVAWNVKYILERVTSGGFISGFASGEGLVCKFTGPGTVFIQTRNAKAFGGYMTGQQTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6C0</accession>
    <name>A0AAE0N6C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_484422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6C0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="446" mass="50718" checksum="10C18E9FE15A1176" modified="2024-05-29" version="1">MATTLVSLPLPALPEGWAAEKDFKPVGKLTKDSAAQRAIEPVGPHFLAHARRARHKRTFSEDDRIQAQERATKVEVDNDSEISEPEDLMMLQRDAKDWKNQDHYKVLGLSKYRHKATEDQIKRAHRKKVLKHHPDKKAAAGRTEDDNFFKCIQKATEVLLDPVKRRQFDSVDEEADVEPPTKKQLAKGNFYKLWGSVFKAEGRFSKNHPVPQFGDDKSTKEDVENFYNFWYNFDSWRTFEYLDEDVPDDNENRDQKRHVERKNASARKKKKAEDNARLRKLLDDCSASDERIKRFRQEANAAKNKKRLDKEAAEKKAIEDAAAKKEAEAQAAKDAEEKAKQEREANKKAKEAAKTAVKKNKRVLRGSVKDANYFASGDASPATIDAVLSDVELVQAKVDPEEIAALAAKLNGLKVADEIKGVWVDEVKRLVDAGKIKETEVKAFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6D2</accession>
    <name>A0AAE0N6D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_283424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="377"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3371940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="54882" checksum="B0BA7059B379899F" modified="2024-05-29" version="1">MNGDHSPPAAGATTASSSFVPTSSSSSTRASPFPPATGAMAAPAFVSAQSFRLPASSQSTLTLAAAAAKSFEPREATKPLPNPYPATSAPQSAARIRCLPLNTSEESLRLMVVFSKDLASVEVLPVEQSPDHGFRSAILKFKTPSGAHEVKNMLDGKSNISNDAKMVVEVMSSSPTGFGNRFTADMVPGTGTSTGASSATSSTNSSRQASRFNGSFQSLDRISPPLGNGVFTSADLTSSEPGGLYHGVFSPQSPIGNHLDRTRVSGKSIINEGDDDETGELLKDPVGFAENGLQRRQTAPHISLSRMASLSLNTTPTTAAAPMSHYGHPGMVGLSHVNAMSPSNVTAMAYGQQQQASYRGHGNFPPANPADQNPPCNTLYVGNLPIDTSEEELKAMFSRQRGYKRLCFRTKPNGPMCFVEFEDVSFATKALNDLYGQPLHNSIKGGIRLSFSKNPLGVRSGPSSVQTIASPMSVMNGVHSGSGNGFTTAHGPPPGLSAPPGLGMNRSAWSRSPSLATGGSNVHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N993</accession>
    <name>A0AAE0N993_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">RAD5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_480955</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N993"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="519"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="913"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1004"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3374818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131341" checksum="8437EF348271E47D" modified="2024-05-29" version="1">MESPGSDEPPNKRRRFFSDADVEQLLKPSTVPHTSSPGLPQRRFFHDVDQDGEPEPVPTTPTPTPSVSSTARPPLLERNAQNSLNPNKIAQTDGDSSHPVASSMAFDQETLENFVGEKVSTDALETIRANCGNNIERAVNMYLDGTWKKLKKPSTPVPARSSPPNLTPRRQGDLATPLRTPNIRRTMPESRYIGAFGAEGWMTRSGTNLVKHGDVVKIERQKIQPLKPVVIKGQTRLTASQTVQRINPNAAKRVDVIVRFTDSTGRELGRLAKETANWVSTLIDQNICKFEGTCVYAPEKLRTNDTVFLQLRVSLLRSSFFSRRFSLSDNRTTRLYDEAETAEEKDLRLRQVALVKLFLEISLVPSRGNAAAARDQRQELLNAAEIAENKEKEKSKPLGKDNPGTSSPPEENEDGQELEQDQLDTLYKKAQSFDFNTPEAEPPDTFAMTLRPYQKQSLHWMMAKEKDERNKEREKSMHPLWEEYIWPTKDYDDQELPLIPDQSSFYVNPYSGDLSLDFPQQEQHCLGGILADEMGLGKTIQMLSLIHSHKSDAAVQARQSMTPATSVNSLPRLPSVSSRAGAVAAPCTTLVIAPMSLLAQWHSEAENASKEGTLKSMLYYGSDKNADLLALCCEANAASAPDLIITSYGTVLSEFTQVASKNGDRGSTRGIFSLNFFRVILDEGHNIKNRQSKTAKACYEIAAEHRWVLTGTPIVNKLEDLFSLVRFLRVEPWNNFSFWRTFITVPFESKNFMRALDVVQTVLEPLVMRRTKDMKTPDGTALVALPPKIIEMVDIELSKTERDIYDHIFTTAKRTLQANVEAGTVLKSFTSIFAQILRLRQSCCHPILVRNQDIVADEIEAGLAADAAAGLADDMDLSALVERFTATTDDAADSNAFGAHVLGQIRDEAIHECPICAEEPMIDQTVTGCWHSACKNCLLEYIKHQTDRHEVARCFHCREPINNRDLFEVVRHDDEVDTTPFGQVPRISLQRLGAGNNSSAKIVSLIKHLRDLRRENRTMKSVVFSQFTSFLSLIEPALTQANMHFLRLDGSMAQKARAAVLEEFKESKKFTVLLLSLKAGGVGLNLTSAKRVFMMDPWWSFAIEAQAIDRVHRMGQEDEVKVYRFIVKGSVEERMLRIQDRKKFIATSLGMMSDEEKKLQRIEDIKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NB68</accession>
    <name>A0AAE0NB68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_524835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NB68"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="955" mass="106265" checksum="BE69370C956E208A" modified="2024-05-29" version="1">MATQQQRPPPNGNGAGPHTETHQSHHQQDHTHAHTHAAHALAHAAHAHAQSQAQAAQAHSHAQAQAHAEAAQAQAQAAQAAADRYKRASRKGAPRRFTCDFPGCDKLYSRAEHLQRHQLNHEPKEIFRCDVSGCGQEFVRADLLNRHKKRHSSSYVPRNRMPSFSAPKDSSPPTTASPAASPTASLEPRQPFVSAPHDAAILLSPDTSTHPPSSLPHPEPPRMAHPSGWPAHQGTHHPHPHPHPHQHPHAQAHAQAHAQAHAHAQPPMPDMASCNIIRPKPGYYPRDGSRVIDQQTSVVAYNVDYPHDEVSRENFAVWLFNPQANYADFTSHLPFSDGGLESTLNNNIHYDYESLTSSRSQLETPPRFVESDELISEFRRVEIVRLFLQFHNKQPKSEPLFVQLVQDSSNGDIPGLSVEMMRDCLQEYWEHVSPRLPIVHQPTFSCNKCSVYLLIVMIALGATSLRSRDSSGNLSDYGSFADILISGVRWEIVTAEEASPPVALWVAQALLLLEFYEKMYSSRRLHERAHIYHSVALTLLRRGSPLIGRSGSESPPEVSSTEPHGVGLDSRTWWSRWAETEAMHRVVFAAFMLDIIHAAMFGHAADMAPHEIRLPLPCDDNLWTATNPDSVRHLDQNLRMYGIKTVSFLDGLKQALHGGEVKTHAFGRMIIMSGLLSVGWHLSHRETHLKWLDLTTPSTADAKDNWKKILLKSFDDWKGSFDVAQGTMGSPTLADASPQRSDSNGPIQSAAVLYHLAQISLHVDIVDCQVSVRDFANVVSRMKVWATLPSTRHAVLHAFKLLHRVLVDPRRSTSERMAQEAGGVKLPPIEVQSYSCRNEPDPHRPWVMYYAALSIWSFVRAVSRHDSLAEPTVHAHVLPRLSKPNPVNFRRVVAYLSNISSLNELTESAAMSLGDGLSDLLDALHSIFFEAHSELLQEAHVRMKVCKDTLVTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBF0</accession>
    <name>A0AAE0NBF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_227552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBF0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="357" mass="38779" checksum="702A4DAB43F36B3B" modified="2024-05-29" version="1">MPLENSYLLPAAADMHVHLRNAPGPISQLVTPTIRQAGVDCVFVMPNLAPRPVVTVAEAQEYQRHLQALDPEVTYLMSLYLHSSITPDEIRAAKKAGIAGVKAYPKGATTNSEWGVVSFEPFYEVLATMEEEGIVLNLHGEVPSNPADGVTVMNAEARFLPVLHDLVERFPRLKIVLEHCTSADAVEAVRSVGDQVVGTITAHHLSLLVDDWSANVNNYCKPSAKSPRDRQALLNAVVHSNGKFFLGTDSAPHDISAKKGKGNTAAGVFTQPYALGYVLTALEEGIIRGDIPDAAISSSKLAGFFSHYGRRFYGVPESKHKVLLTRNGQTIAESFKGEGAEIVPFRAGEKTWSVEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBN2</accession>
    <name>A0AAE0NBN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_477325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBN2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21699">
        <property type="entry name" value="JMTM_APP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="424" mass="44065" checksum="414C4FE17D1D7CF7" modified="2024-05-29" version="1">MTSTVTTFGGSDSLEYGVVQPLTTVWSPPAGCPSIIPERQDAISLSLAGSCFPPNYRQVVENWGYYSPGLCIKGYTVGCTAQQGETRDGMAIKSGETAAWCVPSQYTCTIDGASGSSVVLVTSSSAPDKFVPPMPIRWASSDLALLALATAPITSSRTLSLTSSTATTSATSSSAPSTSSSSPLGPSTQSPDAGTSNNLPTGAIAGIAVGTVVVLTALAIGIVLIMLRRRRGADTIKQNTGGPETGHTPALAGTPKPGLFPHGSSENHKPELDNTYLVTSTSSMAVEADSPDFIMNIPEELPGTPRPNITEMDANQVAVHRVPELPGPPISQRAELPTPTSAMRSPPGPETLLPPGPDSASPSQLQDSGAAIGSSMADQELARLEEKKVQLEQRRQRLLALEQLDAEAAAAIDHRMNQLRGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCA3</accession>
    <name>A0AAE0NCA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_479044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCA3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="196" mass="21092" checksum="53331A3B1F679D88" modified="2024-05-29" version="1">MDTIISEVGDATNQAISSGMVQSAGRMVLAGIAGLWTALVASSAFLFSKTAAVLYALWWTVWWSLSTLYSVFDAILSPIFLVAHYAFAPVRCVLDMLPDFQLLYIFFGIAAVIGILAGTIVQIMSSVTTAVVTGGSPGDQSLKDEQGSENGSWDDGMSWHEAELDWKANASLSSTSKRRAPGYLLSQIIHEEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCP3</accession>
    <name>A0AAE0NCP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_250891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCP3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041783016" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="208" mass="22754" checksum="4844899B15B37288" modified="2024-05-29" version="1">MFNVRRFLLAATLLVGVTLLCFSQPATATKGPKITHKVFFDIEHGDEPIGRIVIGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKQFMIQGGDFTKGDGTGGKSIYGEKFEDENFKLKHTKKGLLSMANAGKDTNGSQFFITTVITSWLDGRHVVFGEVLEGYEVVEKIENAETQPGDKPVKTVKIAKSGELEVPAEGIHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGX2</accession>
    <name>A0AAE0NGX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_200130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGX2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="264" mass="29082" checksum="9ACD8811C60E4ED2" modified="2024-05-29" version="1">MPTTYVTLVRHAQGFHNLTTINQQIPDPDLTPLGRQQCADLCAAFPHHEKITHLVSSPMRRTLYTCLLSFAPAAAAGKVITALPEIQEVSNLPCDIGSSPKRLAAEFEPEVVDLSRLTPDWTDKGPDSPWQPDMAKLEARSQAARRYLRDLGAKHAAETGGKEDAHIVAVTHGGILHFLAQDFDGMNFQYGTGWHNTEYRTYVFADPSGLDPEARLHETKASWRRRRSSSAAGLTETEQRELRAAVSSKIKEEFGGPTAKPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGX4</accession>
    <name>A0AAE0NGX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_450694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGX4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014843">
        <property type="entry name" value="Him1/Fmp52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08732">
        <property type="entry name" value="HIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24900" checksum="9B515EF41CB5E291" modified="2024-05-29" version="1">MASTTTTGASAALFGSTGLVGSHILSTLLVDTASFPIVQTISRRAPKSTGPSLSAIIEGDTSAWTTRLAALSPAPRTVISSVGTTRADAGGIANQWKIDHDLNVSLAQAAKSIPSVQTFVFISSAGTRFTSWAPYSKMKTGVENAIKEQNFEHAIILRPGLIIGDREGKHNSDLFVGAVRWFGNGVKDSLGAEAEVIARAAVHAVKLAEQGKAPSKYWILENKDILRLGRDEWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH00</accession>
    <name>A0AAE0NH00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_202721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH00"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3381391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="393" mass="44255" checksum="35C812E8311A012F" modified="2024-05-29" version="1">MPEIAEIARVVHFLRLHVVGKTIAAAQAVEDANVFGKVGTSGPEFVKAVTGRKVLSAGTQGKYFWLVLDQPPHPVMHFGMTGWIHIKGEQTAYTNYYKKMKADEMDVWPPKFWKFQLDLTAKGKTVNIAFTDPRRFGRVRLVDCPGESIRKYSPLVENGPDPVVDTDMFTEEYLKQKMRSRHVPIKALLLDQTVISGIGNWVGDEVLYHSKLHPEQYCNEFSDEQMHTLYESIRYVCRFAVDKLGDSDEFPQNWLFNYRWGKGTKGAAGQLSNGEKLAFLTVGGRTSCYAPNIQKKTGHIAPGVKEEPLESDHEVPKSKKATNPKTKMAKYKEDQPQDKKKRKMVEENKKPAKKSKLGSTKSSEHASIVKTAEKPAATTEIDAGRRRSGRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH98</accession>
    <name>A0AAE0NH98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH98"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="288" mass="31884" checksum="AE9C2CA1850A123D" modified="2024-05-29" version="1">MHRDPNRTARETSPKTSSRWSGKEPIRWAWGTSGLKPAVPHAKYGNSHEEPSRWKRYSLGQRASIQRRQQDVVLPSSTRSCADCVPTGASVRNAVVESGSTSSPWSKRGSRSSNTWPTLAILGGVDQSLRELHSDMRYWFALSDHTVKIVLLVKFDRARSHVTLESERKIAGGGGPDPTTPVLRQTISITKDTAITSNTGTSSCRGGGALLLPFNLLFLRKPAGPEETDFVFNIGISKYAAELDASPDKALTLYQQRCIDHPTVKPRRRRVGHMIDINVEGYIGEEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNF7</accession>
    <name>A0AAE0NNF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_501024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="626" mass="70127" checksum="8D9AF7821C7B435A" modified="2024-05-29" version="1">MPNTLRRRVPATHDEVETASESPTPRDESPVGDDEHVKVVHHRSKAKTKKRKTTFIFFLGSLFGIIAAGFFAKSNDLIGFPDIGELSMDSLFEVLPAGLVKDMRELVNGERDFLESSDAFSVGLKVRAEGLSAFHPMIMIPGVISTGLESWGTSNISRPYFRKRLWGSWSMMRALVMEKEVWKKHIMLDKQTGLDPPGIKLRAAQGFDATDFFITGYWIWNKILENLASLGYDPTNSYTAAYDWRLAYPNLEKRDHYFTRLKSYIETAVHLQNRKVVLTSHSMGGQVVFYFLHWVASQKGGKGGDDWVEKHIEAWINVSGCLLGAVKDVTAILSGEMRDTAQLNSFAVYGLEKFLSKEERAEIFRAMPGMSSMLPIGGSAIWGELDSAPDDRLGQEHSFGSFLNFRSGQNWTTPDKNFTVGDAMDYLLKTTDDWYRDQIKGSYSQGVAHTAKEVEANEDDPTKWINPLETRLPLAPSLKIYCFYGVGKPTERAYYYRSPEPGIVTNLNMTIDTAFIQGDVDHGVIMGEGDGTVNLMSTGYMCNRGWNIKRYNPAGVKIAVVEMPHEPERFNPRGGPNTADHVDILGRQNLNEFILKIAAGKGSTIRDSVVSNIVEYAAKAKVYDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNN8</accession>
    <name>A0AAE0NNN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNN8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="715" mass="78633" checksum="BE8AD15EBB1E8AF5" modified="2024-05-29" version="1">MQPTASSSARTGNASTVSSHRPGGGRISTARPPGGPVNLPASEYSGTLTHPPGTHVPAPAPSEASTTRPPAPPAGPFPGPAPSDISTNPSTIVPAQQTYELSPPPPPPSGFGVTPVGNKTAAGTTRPRPVSRLPRPVAASGSTTKPVRDPSIAEAKRPEGQGSGSARPRGRVETSSRHPPPPADFDGFNRPGDNYVTTNRFGQITITSMRPNGSVRSVWAGGGEVRDSEYDEATGEPINRERLEQLQKTLARPNLPKACYDWLKESVGLTQGEPEKTPPQSPDLNNRPPSPGRAPTFVPNPRQPEVSPARPGPYRFPAPTPGPHPCKPATVGFLIDTDILFKKEKVPGYHCVMTPRPGATQVISFLVDRKVPFLVFDESDEKNISPKDLSRNISKSLQLKQWIEPKHIVQTTSPFRVLLDDHRFTTVLVLGGDGEQACEVARSYGFKNVLRSLDISASNLQRYGQYLSLEERTQGVKRPFGGGKLPDIGCILVFWTPKNWELDAAVVMDVLLSKYGDLTETVDVAEAPTDLLAAPSWPKLYICDAEDGLHNDNPGEGWIELLRKKWYSKTRICKRGWIKLKETDCGRICDHMTLDFAEVQLKQQANWIEPDGIFWTRVRRDPAMDWEARKRESPDVELTEHSEAVENSLPWMSIRVTRDGRTIADFPEDKRPSLVVDSENMAQGFLDTFQHFHQKLRDEGWIPMLPEGRTFDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNS6</accession>
    <name>A0AAE0NNS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="7">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRT1</name>
        <name evidence="11" type="ORF">B0H63DRAFT_172899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3384898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="747" mass="85289" checksum="F71AD184E08EBC95" modified="2024-05-29" version="1">MAPSFDTLRDEDLDEDDFDEEEVDISDLREKYEVQLEQGYDTFVVVDGLPPVTEELKPKLIKFLLKKLNSVGRTKEENIFMPMGEDGTSQRFAFVEYSSAAEAAAAVRQLDGVPLDKKNTLRVNKMTDIDRYGREGRISDEYHPPQIPPFEPSKHLRSFMADPTGRGRDQFVLFRGENVGVFWNNEKDQPENIVDRPGWTETFVQWSPFGTYLTSVHAQGVQLWGGPDWERKKRFAHPFVNLVAFSPNEKYLVTWSNRPISIPDEGHPALTLDDDGKNYVIWDIETSKPLRSFAQLDTLGAPDENGVKKPIKAAWPAFKWSADDKYVARLNPGQSISVYELPRMNLLDKTVIKLDGVVDFDWAPATSQREGVKTYEQLFCFWTPEIGSNPARVGLMSIPSKEIVRSLNLFSVTDAKLHWQSDAAYLCVKVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTIKDTVINFAWEPKGDRFVTITTTEPVGPTAVPPKTSVAFFCPEKMKGNAIGNFKHLRTLDKKNSNAIYWSPKGRFVVVATVHNQQSSDLDFFDLDFEGEKPESDKDMTANLQLMSTADHYGVTDIEWDPSGRFVATWASAWKHSMENGYHIYDFKGEALREEPIEKFKQFAWRPRPATLLSKEEQKTIRKNLREYSRIFEVEDAERVNSADVAVVEDRRRILQEWLAWRESVEADVAEERAELGLPIDPIAELLKAKTAELGPDEEEKIIEEIMEEVLEETEEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPQ5</accession>
    <name>A0AAE0NPQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_182459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPQ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041916516" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="99"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3385411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="393" mass="41008" checksum="9B79887644ECBC4F" modified="2024-05-29" version="1">MVHLASALLIAGAALAIARPATEIFERQTCATSDKYPTVNVAKLPDPFTNAAGQKITTKADFQCRAAEINKILQQYELGTYPPPPDKLEASLSGSTLTVKVTVGSNSVSYTASIKKGSSPAPGPAIITVGGSSLPIPGTVGTIGFGNDDFAAQGGGSSRGKGKFYTLFGSGHSAGALTAWAWGIDRLIDALEQLGPDKTGIDTKRLGVTGCSRNGKGAFLAGALVQRIALTLPQESGSGGAACWRISDQQKSAGKNIQTAGQIIGENVWFSKNFDPYTKATSTIPADHHMLAALIVPRGLIPFENDIDWLGPVSTTGCMKAARLIYKAYGVPTNMGFSLTGGHSHCQFPSGQQAELTAYINYFLLNSGTVPAAVERSTATADGWAPWDVPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPV8</accession>
    <name>A0AAE0NPV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_183066</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="427"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3385445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="558" mass="61868" checksum="08535EE5EAD2A7DE" modified="2024-05-29" version="1">MTDNLAAKLQASTLNDGDDSESWKKSLKAPAKDTRPQTEDVRNRKGLEFGDLGLSREVLMGIFEAGFEEPSPIQEEAIPVALTGQDILARAKNGTGKTAAFVIPALQKINPKVSKIQCLILVPTRELAMQTSQVCKTLGKHLGINVMVTTGGTGLRDDIVRLQDPVHIIVGTPGRILDLAGKQVADLSECPMFIMDEADKLLSAEFTPVIEQLLQFHPKDRQVMLFSATFPLSVKDFSDKNMNSPYEINLMDELTLRGVTQYYAYVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMAQQARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLINWDDRFNLYNIERDLGTEIQPIPPSIDKSLYVYENPETIPRPISNFTPSAPQQQLQIQQQQQQQQQPRGPPAQQTQFPMPQSKTAQPDQGDWQPQNSRQNGSGPSNSQGRGGYQGQGHRGSSTGHRGGRGRGFQGQGQGQGQGRQQQSQYVPRGGRSQGSGQAPAPVQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ13</accession>
    <name>A0AAE0NQ13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_449596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ13"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041961779" evidence="2">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="11209" checksum="B92AAAE18EB1F0A6" modified="2024-05-29" version="1">MIFTSMGLDALGSRLLKVLLFVVFVFATFSQALPTGQSNDIISQPLAARASSASAEAISQGAIAAFSIGGTVGFIILVCVVVYAVHVCTKDDENKQTQTNSTQGVGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ89</accession>
    <name>A0AAE0NQ89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_560232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ89"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="761" mass="86544" checksum="89FB562C20F09ED9" modified="2024-05-29" version="1">MRLINVQTLQLVECLPISQPPYAILSHTWSDEELLFRDLVTSSPHREERAGWQKVVAACKLASRDGLRYLWIDTCCIDRSSSSELSEAINSMYSWYKEAAVCYVFLADFYPSSLRSIDQSETFTGLTAQSREDGDLLQRCRWFWRGWTLQELIAPIDVKFYSSDWRIIGTRSSLQHELFLITGVDPFVLAGGDFRAVSVARRMSWASRRNTTRVEDMAYCLMGLFDVNMPLIYGEGEKAFTRLQEEIVKTTEDLSIFAWKEGTSWKDYGWIFQEGLTTRNRSRANSAFATSPADFERCGTMFPPLGLENTDDDDSASDALWNTASTTSSVTLVETTASGLTNSGLKQAVSFLLDDAELSSLFRKAVERRGVGLDRFRRILVGILRCLAIELAPEATHHNETASAIFIRRYRLLIASAVAADVAQHLKPVQIEASEFPHEEVDEEVEVIGRDELPAESDDEEDESDRPMRAVKELEAEPNFSSVYTFIRSSAAFQNMIKRLDDLAHPSFTSRATAFVDRLLKAQAPHGSGNEYWAGMKERMLVVISELSISPPRHVFVTDQHISSIPDRVKLAVESMTNEEWEWWPLQRPSPGSKPGEVKLHWTCFEKYCRNGYAHRGYGLPDQHRNHYKYALTTLAPPVSPEEFKHVFKHSANSYSWTTILPFHTRRNPDLPSDTVDRIPQRLWNFDKHSGNREDFWGLYVRERRSALMTALYVLLCLAPFIVFVVLYLLGVVQGDVQNATTPLAISLTCLSLLFSSTIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQY5</accession>
    <name>A0AAE0NQY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_560546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQY5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="77743" checksum="7346E6E19082E92B" modified="2024-05-29" version="1">MASIGDAIRLEAMPALQRFADNPQLGRFDRDDPPPYTTYDSESGSDFDAPFHPSLGLGLGKDDSDSPGRRFQVEVEHETSLLGAFRGWGPSNYWAKEFLKASSGRQSLRYSPIVRCNIRRRWQKLGIWNPAWGIPGRQDRQPNDDTDTWKWKWEQDIPFDEKHPAMRAVRLRQGLRHAERNPPPPFSKLNEDAAPGQAESFIISRPWFTFSVEKAEQMPIDSKPMMKERDRRRFDALSEWAQQHGAKLHPSLEIYDDDITKFSIRAKETATDALEPGFAAFSCPLPITLSYLNALVGGPITPSAPPGQKEPAFPPRFISTLPPHVVGRFFLMQQYLEGDDSFWWPYLATLPQPEHVSSWALPAFWPEDDVDFLEGTNAQVAIEEIQANVKREFKQARKILKEDDFPNWQDYTRVLYNWAFCIFTSRSFRPSLILTQPGKEHVEKLLPQGCQVDGFSILQPLFDIGNHSITSSYSWDLVSDPNSCRLICQDAYRPGDQVYNNYGLKTNSELLLGYGFVLPETNELHNDYVHVRKRGRGGDDSTASDKPKDFLISLRPISHHSSVVIRAREIPSSAGSRLHLLSEFAHFEPALVYDLAAAVSTPEEIQIMEQSTEETPQGGLEALIKRVKEALTAKLQFDYQKLIDVDQVEEEDRIKPTNRNQQLAVNYRRQCEKVLLASLEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRD2</accession>
    <name>A0AAE0NRD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_191904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="157" mass="18045" checksum="5D1E02C2D223D0B5" modified="2024-05-29" version="1">MAWNCFCCWFWRCRWRVCRKSSFGAYPRLISSSTSWGALRDHTRHVRSGPIHRLPQTSRVRHVVVSAGIYGTSDLATRTVWSWCTRWKPRPRSPPPPSMTRKQAGLEWQVLASETPRNLFLKSRLFAPALREPAGAQDSPSSTGWGALRNRTNARKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRP8</accession>
    <name>A0AAE0NRP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_508500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042197451" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22144" checksum="84A692A51BEEDF69" modified="2024-05-29" version="1">MRSTTAIGFLSLLIPFVSGFHVSGNEVEGGLYKVSIDARGQQVHELLTPDLVSRDAGLAKASNALVLADREIPARFKSAAKELFAREPRLYCGCGIVLDRSDCDAAVDNMKVQIRNHGGRVFVPIGQAYYAVRGGVVSFICTRRGNNAITGVSEGDFTNLLGVVTQNCGLYVAGTYRHGDSNASEDVGYMNAGGDFCGAAEASNKERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRY1</accession>
    <name>A0AAE0NRY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_411527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRY1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="192"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="726" mass="79914" checksum="EAB469BDDED885E2" modified="2024-05-29" version="1">MAGASVHQPERCKLCSNLIIDEDEPRGTGLHGAPYVSYLEESHKNGCRFCGYLLQIEHLLGTFVRWNFIGDSYSGYCERPTFESLKISDPTCLTSRGERIVVRPFQVWHKSLEIYREHSGLPSPFSKPIAVGERADSPSTWTFLQDCLAWCATHASCAQEGLLRLPTRLLHLDSSAGTVSLVETKQGEAMPYVALSHCWGGDLPVKLTTANYELLRRGLPWGCLPNTFQDAAVVASRFDIAYIWIDALCIIQDDTADWAKEAAKMADVYSNAHFTISAASSKDGSISFLKQQRTMPLVLGLEDNMDIDGPPERLLARKRFETGIHSYGKVFDATLDPTDLRGWIMQEKVLSRRTMVFSSEEVQWECRKARVCECSGITPWDSNIDQRMHGTARQDPRKASRGPASLETWRSCSPEQRHESWNTLVMDYTLRSLTNETDKLVALSGMAKKFSSYDSSAYYAGIWHSSLPSGLCWYVYQHYRVQSLLPQSYIAPSFSWASVKGNVDFMPAAAGPGSVSACAIINSAIVSLATADPFGAVLSGSITLAGVLMAGEMCYDSSWAGIRVNRKSGNRGAYTVSFKGTVELMSDQELPQFFHDCELIPQGSSGVDAGGEQATGGVARSSEASPTSWGPCKVYLLPLYMATPTTSWGVKIGMYGLVLGRRPGGTGNFERLGLYPFGFDFGGLDSEDMSSREERIRGFFAAGTPQVVVIRIVGGLSRHDTIIINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSA7</accession>
    <name>A0AAE0NSA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_447670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSA7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041998500" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3386761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="118" mass="11385" checksum="342D5DF10C1D93B6" modified="2024-05-29" version="1">MLSAALFLTAFSLLAAAAPQVTTDIPSQITAPPALPCSVASAMPSCGVPCIMSAAISIGCTTPMDFACQCSHAAAMQAAVMPCVASACGAQAPVVGSVANAICTACVSSVALPTPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSI3</accession>
    <name>A0AAE0NSI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_520963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33200" checksum="7D442592D23C1EEF" modified="2024-05-29" version="1">MLEHDVAAVSRSNMRSDADHVAASNGNSSIDNDVENGTSKESPNNGIAEDLESHHFVASKSLVRRQDKRIVPLSAVIYFLCYLDQSNIGNGKIMNASTHKDLLTKTGMTTLFQHPAQKTPPLALDRVPHVLLGRYTHGPGRANGYAAITGVRFLLGVFEAGLFPGLVYYLTFWYRADERSVRVSFILASATLAGAFGGATAFAVGKRMNQVHSLSAWRWLFILEGVPSCLPAVAYGQKAGVWIYKADEAKKGYPTGHWVNDALLFVVAVGCSMLRLYYGGRNRATVKAAEGAAADVRLFKYSLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSI5</accession>
    <name>A0AAE0NSI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_521016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSI5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="297" mass="33158" checksum="33DD0293608F51B2" modified="2024-05-29" version="1">MADLKRYLPEKFKKPKKPISTKMLNLGGNSKIWGPGHLILNALRACTIITLGTVIVSSWAMIVLSGITGHFQFFDMISHFFTFMTSIFLVISELGLFKTYFEKHWPVLSPGHSLMWLGFSVLVIGCEMLADTVKPAYTEANLGQAMYRLVLSAGILAVIMGVFNLLCSVIFRDGEQGITARMIRSHGTLAAMNNRAFSAKAHSARSFSNGDSYSQRSEPYYRQTDEEKPSAMKRMTNYFMVRKSQISRPFISSPLEADVEHNARAGPLQPDIPRPPTRLHPAYTGASSHYSVAHMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSM7</accession>
    <name>A0AAE0NSM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_558501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSM7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3386900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="737" mass="77578" checksum="2DF776B12B07D8B1" modified="2024-05-29" version="1">MEGLPDHHCPCYVDAAALMSRVRQGDTRQCLQVCKSIFLQSVSTDWTETHGWKEGCQNLTSKAALYEFWQLYWCDSTFCGVAISPTGGLEQDPNVDLIINTCQNIGITSVLDPGPPTSGFSCQTDAKEASQCPNAHGLSGTLLANTKASEGNPFSQTQTETPKTLLSSKPKQLSSTLPTTVTAPLTTRHYIPSTLTPEPTTLITATSLLPQTLVVVESSTTPTVLGASATSAGNSTTSSSGLSGAAKAAMAVCSVVGLVALIFLSALCLRRRQRKRQQLHRHRRLRSPSRLARDGPRPNSPRSLLISPSSYAADNNSPPLTPPLRLRDRKFLPSILRSSSNRSPSPPLTPLTPAYSSTHNSAVFPASPLCSPTTSKLVPRAEGRTALRTYGDDVHPQISLAMPNGGTIGHGRHVSRGSLGSSSVAPSSTTGPSSLRNEVHATNFNYFTRSTPPPPPPPTASPTRPPRPQEAPLEIPDLVSPAPSPYTMAAASPVGPPPSRALPSPPVSPVTSVGGSSTVRSQTRAVLSHHEARDLEDLAEEYPRSSWGSWSGTGTGSGAGSTTTTTAGGSKVALVLPSSPTKKSRNSSARSDSTKIQTPPSRSSQFYTILECLPRERLAGEDDSTDAYPLDAQHDPNSSSVLAWNLTTHEGHCSLAKESLIFPSSPLSTGRSTYHAANAVAPDCHPPQTRPCGHGYTHRPAAACSPGKWTRQHGVAVSQEGRKCGLAGPGIAAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT44</accession>
    <name>A0AAE0NT44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT44"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10531" checksum="C61A72368147901B" modified="2024-05-29" version="1">MMYATRAALQAFRPTIRMMRPVPKEEQSAHTISQRLRRLKSIPPELIPLGVVVGFAVLAAGYSSIRHFFVDKTIRLKRQNRAAESHAPSGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT51</accession>
    <name>A0AAE0NT51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_147070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Lipid-anchor</topology>
            <topology evidence="1 6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781473" description="1,3-beta-glucanosyltransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="430" mass="46679" checksum="913876F09D16BA3D" modified="2024-05-29" version="1">MRLTLGLAAVVLGAATVEAIQTITAVGNKFFLKDGTQFFMKGIAYQLTPDDPLVNEEQCGLDAALMKSLGANAIRVYHVDAKKDHDKCMSLFADAGIYTLIDLDTFDTYILPNDPWWNATQYKRYAEVMDTFIKYDNVLGFFVGNEIIAQANQSNAAPYIKTSARDMKAYRDSKGYRKVPIGYSAADIAELRPMLQDYLTCGGNSSEIIDFFALNSYEWCDKTTYDVSGYATLQLQAKDFPVPVFFSETGCNVPGPRLFEDQGAIFGEKMVNDWSGALIYEWIEEENHYGLISYGPKVAPTVTGSNIQGGFTRGGTPTPVSPDFNNLKSEWAKVKPTGVALSNYNPSSVSTRACPTSTKDGWLVQGNVILPTLGETYTGGSSPTTAPTVSGSGSAAAAPTTTKNPAPANREIAGMSAALVGVMLFFTFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTL7</accession>
    <name>A0AAE0NTL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like cysteine/serine peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_376638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTL7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="229" mass="25007" checksum="99618C036E0C6E28" modified="2024-05-29" version="1" fragment="single">DLLAERNVLGVDNRVNWNQTVYPYNAIVKIEWVGKKLCSGVLVGPRQVATSRQCAPAIGQTGQTFKFMPNYYFGERYPSAGMINWYMPTMVGFGDCGVKDDWAIFILNARLGDTMGYFGAKNLDPATQLNGAQFFNYGWPQDRSAGGMQPTRQEAISVTALGTGCEPGGSLQTNADSGPGQLGGPLWAVESGSRYLYGVLQNEYRSDYTPFAGGDRLVAAVIKTRQDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU85</accession>
    <name>A0AAE0NU85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_165484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982184" evidence="1">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="20404" checksum="2F240AE3F1C060FE" modified="2024-05-29" version="1">MARLWYTYHTILLLLAIPFLAASSAAPSPLPPCSPLPDANTPLWNLSDWSTDYTLPDDGGTVSFRLVNALTGYGALCVRVGPYPEGYCVSGAGQGGTSTGVEEGDDDDTGTLFTYYEGVDGELSVYQEWSCGGVAGESGGTTKRIQVDGKVMVRNPSQCGPAGPGHDEMKKGEMCGLQGGQGVIYPTLVQATPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU87</accession>
    <name>A0AAE0NU87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_470587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU87"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="40594" checksum="406BC6DAE0A4E43D" modified="2024-05-29" version="1">MSCETGIPDWSNVTFATFNQTLLMFPRLCTACTCPLTIEGWFLGYMAYFPSLAGNAVFAAIFGVFLLVQLYFGVRFKTWGFLISMGGGLILEVLGYVGRILMRDNMFTNTYFIMYLVCLTIGPAFLSAAVYLTLSRLVVIYAPDRSRFRPQVYTYIFIAMDIVALILQAAGGGVASLAAPYSAALKAGVNTMVAGVAWQVFSLAVFALLSLEFWLRVRKAGEKGLNPAFADLRAERNFQPTFIVAVFGAGVFIFVRSVFRCAELSGGFTGPLANEEITFMVLEGTMIVLASGLLTFFHPGFVAGTERWAKASWKAARKPTIEEGVSERSASSGDADKTPSKTAIEGVSDSRSGSGIVVEKTADRTEAKTASEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWW3</accession>
    <name>A0AAE0NWW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_506858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43968" checksum="114EC3B0C613E53E" modified="2024-05-29" version="1">MYQSSTPHQLSSSLQSRFADLVMCYPLAPSLHPQSLYIVVSPPLSFYPPLASRHFGKASFPFSSIMAASGEHDSPIGATDLSTIFPNDETSQNVLATRRKQQQEAAAAALKAEQDANAREEQRVAREKAAEKEIAALKSRAEGLDDEVAALKRKTQDLSNDATTAKQQKTQAETQSVQDRARLETEMAKLKQEKSDADASWRNTCNNLESHINELRNERDRELAQKLDPSNNLDVNYDGQEVYIINIKARTTADHNPGTSTPIVRSWTWEYRNPNQRFVLDKVNRNDPRSPWYIRNHNTSRYWEFREAGSDKDLYAADRRGDYDGSLAQQWHICLSSGGSVLFKNVRFGTSVDLYSTENGKRGERLRSYDVRPEDPCQRFTIFHHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX35</accession>
    <name>A0AAE0NX35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_96044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX35"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="261"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="427" mass="46513" checksum="57F23E5F02F70120" modified="2024-05-29" version="1">MAPPPTARVSLKAFLATAKKALAAPPAQRPNPLTFVVGNESADLDSLCSALVLAYFRTHTPPHTLHIPLSNLPRGDLALRSELGAVLGPAGLKPEDLLTLSDLPLREHLKPEDTRWFLVDHNALTGDLAHRFADASSSSRSSNDNLVIGCIDHHDDEGAVPQNVAPRVFEKSGSCMSLVVDHFKDAWGKLEPSREVDAELAHVALGPILIDTTNLTAKNKTTDWDVRAVELVESRIMGAGVAAAGAGTTEPASSYDRTKFFDDVTHLKEDISRLSYRDIFRKDYKQWNDGDGSNGLTLGIAGVVQGLDFLVEESRGGKDKFLEALQDWAQEQKLDIAAVMTTSRPDGKFTRELLVWAFGEPAVKVVKSFANKNKDSLGLATWHNGALDKDDGGGAEWRAGWTQSRVEHSRKQVAPMLREAMKDSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXB4</accession>
    <name>A0AAE0NXB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_463328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXB4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="385" mass="42960" checksum="A3141EBB6656958F" modified="2024-05-29" version="1">MADDDGHDTTGIYDLRKDLRMSMIIAAFTGISWYIGAEINTSLFILFKRRRGLYFWSAALSSWGVVLQPLFIILADYGIWTDLKGSITVVYLTWAVMVIPQSWLLFSRLHLIAYHDELLRWLKVVLLVNSVVFGVTTVVFGIVAQSVNPVQLWHINLVWDRVQLTVFFVQETGLSLLYIWHTRKYLRDSSLLSSNPNTSRGGNSNALYSSTRPISETKQVLHHLVYINILVIALDIALLGVQYADMFYLQGAFKPCVYGIKLKVEFEILNRLIEMVRRRGKGQSSSYNQSAAGTGVLGPEGGSAGDLLKGKASSAVQTQQRSLTTIGGGENNNNNHDHDIGLEHLDGVPKPGSRSQSHDSHESQVPIWEGERGHATQVYQVGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXW4</accession>
    <name>A0AAE0NXW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXW4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="49325" checksum="DC1662A7662972F5" modified="2024-05-29" version="1">MGTLNLDRISRIGLEFRAGRLAPMELLWRTRDCQVSNARDKVVGLLGMLVPTRTEEKFEPDCTWPVETLFYHFAKYVLRNCTFSERTALLSFAGLSRRRGSPQQEENPEPPVAPLPSWVPDWLAHGSLSPAIFAILREKPFNASKGMFPVTYSLGEYGTAECFITQVEFSLGTIKSLSRTEPELKTDDYSDRAGPVQSTSQPANESPVLTSRDISTASLRHADLQWLRWHNDAVQVFHAARSMGKLSRYEDGVDTAFALTLLAGDDYKEANATATSILIENLSEVFAAVVEDISLDHPRLSTSFNNAAGMYRTQTVVAHRGRRFAVTEDGFIGLVPACSEEERKYVLVGGSSIQDVIEGEIAEGLSAGDRDPLFIYQWTVVELRVTAMGSICRFSEDKSRQGWNEAQNRMLQLLLERQASLAVRNHGTANRFYVGVSFLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY57</accession>
    <name>A0AAE0NY57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_104432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY57"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041777339" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="299" mass="31773" checksum="88859733382782BE" modified="2024-05-29" version="1">MHSPTFASLLTLAAISRFGVQAQQQKALTPITNFGDNPTKLELSVYVPAKLSPKPAIILALHFCGGTGALYSQTTKYNSLADTKGSFVVLYPTQKKDNNCWDVATTKSLTHNGGGDSNGLANMVQWAIAKYDADPSKIFVTGSSSGCMMSNVLAATYPDLFAAVSCYSGVAAGCLAGSPGSSPQSADPKCANGQNVKTGPQWAAQVRAMYPGYNGTYPRFQTWHGEADNFVNYPNLAEQLKEWSAVLGVTFTKNNTNTPQSGYTQLVYGDGTKLVGYSAKGVGHTVPAHEDADLKWFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ83</accession>
    <name>A0AAE0NZ83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_465559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ83"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="429" mass="47627" checksum="0C04725BAF7AAF0E" modified="2024-05-29" version="1">MPLPFIAAAFLEGLPAWVPDPWLMLKAGSSLGALAVAKRYMSGAMCIAERDMHGRVVLITGGTSGIGAVTAFELAQRGAQVVLLTHLPPSDPFLVEFVDDMRERTGNDLVYAEQVDLSSLHSVRQFATRWIDNAPPRRLDMVVLCAATLTPPGSKRTETPEGVETTWMVNYLANFHLLGILSPAIRAQPFDRDVRIILPTCSAYISSPPLDLVIQDKDWTPGKAYARSKLALMVFAKAYQKHLDAYKRPDELPMNARVFLVDPGFTRTPGSRRWLTRGSLWGLILYMVFYAFSWLLMKSAEMGAQSLLWAMLEESLIRDGGGKLVKECMVVDCARRDVDDEAVAKKLWEASDKLIERVEKEEALKRAKGKKEQEKREEDAKNAEQVEELESLLNTIKNGQQAKESQKSKSNTAGGGKKQKSSSSKPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZA7</accession>
    <name>A0AAE0NZA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_113950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZA7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="23929" checksum="F40CB160B5DEAB20" modified="2024-05-29" version="1">MYVRRCAPAPCGLPSRRAEQKCSNQTQTKNAASLPTLFAPCLASGKQAQAPCIPIHAVLSHWSATPRRAFANPSVRETARESYGYLQRHCSYRCCCWLRFQQPAATKPANLLRAVCCWVGFLLSSDWQAGHRLGLCHTPIPVYKCRRGRILACLSTRSLPRPLAHCSLLCPHSHSLPARHVSVPAPCSYTRLALKVQDCPHPILSLRPPSSNAALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZH0</accession>
    <name>A0AAE0NZH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_119764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZH0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="986" mass="108178" checksum="AE8655A04E9E07BF" modified="2024-05-29" version="1">MDSKRMILLEDDSLVSQSGPRPSLSASIRPLSPFRKGRYVVVGDRGHGHATPSHHVDLDPSQAHLSCVTQNTSQEDCARHRFIVWAAVKRNTSQRMKPEERLECPLLRCTQRFTDHESMLRHLAGCNHLPSGEYWCYDHMRVERFDDLKCKRCLGHPSKRKKMLSMAKTFFHSLGHKSKKGNGLGFDGDEAMLLPPPSYDSLGIPPANANATELSSTEIVEIDSVEVHTIHAHAPGLAATLPSSDGAIDPQALLVPSLPELDSTAMSNDSFMQWHPHPHPIVTSSSYPTGLSEDGESRSPSSSKPTLQVTTHGLPARRHAPRPVPRPVPVVSRSKGLSPSSSVRSNASTDTTASTETSASTTSNISSIVSPISSWSGEWSMGDGINTSMTSPIDGFLCDDAFDQAFNTACPDFLHDFYSELPADPPTSKIANDMASDPIFMLDLAPLPDSTYAMDMLSENPTSSTDVNGMETEKADVCCSEAKSIAGSAWDALQEHIVSSMVKIQSVQGNRLADKLRSMSGKTIAIAGFRAVRTLLNGGRPSSASDILCFVHLAYALSLVVHEQGASFRSKNFFLQSLSYTHSLPPSERDSYSQLAFAIWQPSELIQADIDRYFAMLPSKSLSRSSSLKGKSPEIDNGYLEDNDLDSLLIATQNFLDEFESSLILGQPQLSPEIFTSALYMKHHQEVNFAPFSESFYLAVPGVLHSLAKDFADAGDLQNQLGGVYKRVSDGAISTARRFEIELLSTGKACMTATRFFASFVPRTRDLCDKIYEEPGSNFPTRAVYHSLGISLFESLIPEFDNSTGDAAGSILEEHDLDEMFNQITVDNPFSNLATADSTDYNIGNPSCLYTLPIDLQGVEMLSTESTSSSQNPSPVRGQSVQVELSEQQPTGEEKVEADACCDLCGYRPKGDPKWFKGSMSKHKKLQHSEAPPKIYKCPYPGCSSQYKNRPDNLRQHQMEKSHWVQGDDGASRRPSKRKKLAVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZR2</accession>
    <name>A0AAE0NZR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_429390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZR2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="450" mass="47176" checksum="AC3989B3F886E86B" modified="2024-05-29" version="1">MSNSDAPRGASATASGDDDDDPIVASYNVFIKPALPANRKLVVLQYVNKTSQDPSNLRAPRISEVRVKPGTGMYEVDVPIDTSEAGYDRNKGVIWGTSLQKTMEIKKGGSLGLAGGFNVGAPSARGGGAGGRGGRRGGAGGGGDDDDSNVQLSWAEAARQGKVLQTQTLIGGSSAEDIINKMHMVGVFQGKNIHLTPVSSLVHLRPAAHHLDAAVEQERLNRASTATAPVGSAPDKSAGRAIHMTLKAAMDDDGVATETMADRLRSVQTEPWRQMEWVHDEAEAAWEAYNECLLLRSGKPSTTTNPTPAAKDDSEKDKSKGKEIEIIDNPAETNNDDSGAPDLAEKVPLLKTDWNEDQLLRAVSGIGPKDKKPGEEAVSAPGPVRSLPGPSKAKKPAAAVKVEKKPAAAEETKRGRPGRPARSTATAATRAGRAPLKPDTSGSTSGLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZY6</accession>
    <name>A0AAE0NZY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_122450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041918159" evidence="2">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="317" mass="31522" checksum="985B097E76025C4B" modified="2024-05-29" version="1">MRVSFLSLVGAAGLGVVNAWSQWPNCEPNNCYRNFLDDRFKELGKAWCPKFLAGTTTNGAAIPTEFNNCDSNVQAVSTACSCITSANPAPVVTQAPVVVAPAPTPKPVVVVTTPPAQVVVNQPVVNQPVVNQPAANTPAPNPPAAVDTPAAAANPPAAAAAESPVQAAQEVPKADSPSPQQITSPSSTPSELSPSESSSSSSSSGGLTPKSRVSEKGVLYSTSTILGSFTRTFSACPSSQTSCSSSHLVTTTEVFPISTKIFGVTTTTDNGTPGPSSSAPAGGPAGGNGNGGVSARGGVEVAAVVAAAGVLAAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0S1</accession>
    <name>A0AAE0P0S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_127029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0S1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="527" mass="57707" checksum="50347AFED7272BD7" modified="2024-05-29" version="1">MSLQSPAPGTLKRDSSDVEKLDLDNSQTADGERQSPKSWWASLFVVEDGEVYETHPEKNARWYQRLLDAGVEENGIKPVPVEHRTVTQYNNLFTVFFTCLLGIIAIPTGMLATLGFGMSLRDASLVILFFAMLTAIPPAFMCIGGMETGLRQLVQARYSFGRYLVTIPLLLNAATLTGFALVSSVVGGQTIASLNPDNVSINIGIIITCLVSFGISLLGFKAVHLFERWTWIPSLLAFIIAVACGGKQLRLQSEAEPATARQVLSYGSLVAGYLITFGGTVSDYSIYHKPEGTSRRCKVFFYVYMGLFLPTVLLLVLGAAIGGAVPNVESWNQAYAITGVGGVMYEMLTPAGGFGKFVVVMLAFSVIGNIAISMYSVSLNLQMLLPPFAKIHRFFFIFITMAIMIPFAIRAAEEWEESLINFLAIIGYWAGCFDAVLITELLVFRKMDYTTFEHAIWNVGKKLPPGFAALGASLVSMALVVPGMAEPWYTGPIAQTTGDIGFEMAFVVTAIVYLPFRWLEIKCRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P598</accession>
    <name>A0AAE0P598_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_457754</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P598"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="34"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="542"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3393210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="827" mass="94346" checksum="D218EA0536711BB3" modified="2024-05-29" version="1">MLIVKDLKARTTTWQSNRTSRHHSSKIPPGVVVMKFGEQLRSSVIREYQWYYIDYDGLKADIKRPTGSAPTADDSTTRSSKLSRREWTEEDESRFVSKLEAELDKVHTKQQVKAMEISRRIAVSEREVRDVVNRLNERGLNQEGPSEEEFMLLEEDLSDIIADVHDLAKFVQLNYTGFFKIIKKHDKMTGWHLKPVFDTRLKAKPFYKENYDASVVKLSKLYDLVRTRGNPVKGDSAAGGSQASFVRHTTKYWVHPDNVTELKLIILKHLPVLVFNASKEFDEQDTAITSIYYDNPETWDLYEGRLKKTEGAEAIRLRWYGGMQSETIFVERKTHREDWTGEKSVKARFALKEKNVNSYLHGELLPAAIFEKARKEGKKSEKAIAEDERLAAEIQWSVIKKGYKPVCRSFYHRTAFQLPADARVRISLDTELSMIREDNLDGVRRSGDNWRRMDIGVDYPFSQLPPGDIVRFPYAILEVKLQTQLGQEPPEWVRQLISSHLVEAVPKFSKFIHGVACLFPERIHLVPFWIPQMDVDIRKPATHDFGIQRPGHSATTTTSDDEDDEDDSDDEQPLATSHDGQNGHNGASTSSQAIVEGGLRNRRPHALASDIEDQTVERAGGDVTYLYDSDDEEDQDETNRLEEARRVGGWTYYHALISTTADAVGRGTLSFLKAITPRPRATEVPRNPRLETLFGSGEIQTKRFKAPKGKKIYVPVRVEPKVYFAAERTFLGWLEFSIYIGTIAITLLNFSTKQGSPASFIAAGAFTLVAILALLYAVGIYLYRSQAIRTRRAARYYDKWGPSVLCGCMFVAVALNFAYEGKDRKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5M6</accession>
    <name>A0AAE0P5M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">B0H63DRAFT_25317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5M6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3393707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="32101" checksum="0BC06447BC7FFF38" modified="2024-05-29" version="1">MASLNLSPEELKQLELVRNRTLQLTHSLVSLKTNVFNTHPLPSRESLQASAIILQQNVKSIQEIANENSELFQRIAVHPSTNFPGRTHEHLVYQLLRKKLEPAVEGWVEEARETAKAAGLDPNKLGTTRPNGGRVGGGYGSDDDDDDYGLGMDEDPPSDPFNDQWADIVAASDEKIGSHLSKQVAQAYTVAEQQMGIENVRTGLKRTLRAEDADSSDEEDDEEDEEDEDEEMAGTERDGADLPLSGPGQKIEPELVLWLAARGDPFLPPNIELEWQRKQREAAKKGGVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P670</accession>
    <name>A0AAE0P670_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_32593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P670"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="425" mass="45728" checksum="2C88A70AE8BE34DA" modified="2024-05-29" version="1">MDSVYSDQNVDETYSQSSPRSRTGSAVSTTEGLFQTLRLAESPAHPPSYDSGSYTSSRPPSSRGQASPAYISPRPSHSATFLPHPIPQHQPPFPRSSGGYLDTEWFDTDRNQAAQGTPLLRVQPAPEQSRASASSPPLVSNQHATMSAVALPYDAGFSMGSRSSYTWPVMESGGGLLGQDLSHYGSEASLTPPSGSRSVTASPPRGALTPEQRELKRQRDHARHNSKMHVRGRRAGSNSSSVYSPPVTLADLTTAASSMPIYTTAPPQISLLAEPSSSQYHPGFSPPLPDHSQSNMFAGHYPPPSYMTDYGYPTSTAPNLSSHYGRPIMPDPSLGMYSVPSVMGPGSQDATGQVRVVQSRPKPQCWEHGCNGRQFSTFSNLLRHQREKSGQAAKASCPNCGAEFTRTTARNGHLLHDKCKGRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P683</accession>
    <name>A0AAE0P683_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferases subunit 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_25543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P683"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="701" mass="77343" checksum="93F57D4D19DD2A77" modified="2024-05-29" version="1">MPPPSSQKGTGKKGGASVMRQQQQRSRNTTPSAIPAVASLPPIENVETETLDLRFEVFRNLTYEDMVEPSASNAIIPDSKSLDGLLTRLQRLGEVIEKRGTYCDRGMRLLAQTRKVRIDEMAVERGREEERRQKAEEDEERERKANKKKRKATENLAPQGSSIERSSPLRESNAAKPRKLSRDSTSSSLSPVAPRTPSNMDVDDKAKAEENEDESESDNEGRPPPPARPQANTFGDDPSIFPDPTVYEILSVKPGMTQDEIREIYSVATYPKSDLGDLIAGDPPDKDFSNAKPSNQINFSTFSTYIEPYFRPFTEEDLAFLRERGDRVTPFVMPKRGKKHYTDVWAEEDGAMAIDSTPAAGREKLPPNQSRGTIENMDDEVAESDKLSVGPLLSRLLAAMRPEHRAPAPEAAVPNGINGTDGDSMNGITSYDTHSGENAPSQLQDVPGVNGSAVNGVNGTLLGPNGEQVLPPATYMPESNNPEAWKKGTHPKLDYSHVDERIKQELRHIGFLPILPGHDPANPSAAPAAPDPATTADYDGHYDDEVAARMRLLQTRLREQVLLNGARKARLTELVKERMAYQEYQTILEDLDSQVQAAYLKRTRTMGKKPKKARPGASSSVAPTPGGGVAGMARPGIGDLTKTLMERRRRWIESIGTVFDDEGLARVPRVSDEGSTIFQPGEMASLIRREKDAWDEEVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6A8</accession>
    <name>A0AAE0P6A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_444378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6A8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="37741" checksum="CB27AC3823F5D81F" modified="2024-05-29" version="1">MSDLNLITAREAPGGPPPGLGDLSRMRWSAKHPPIDPKVSFAGKTVLVTGANTGLGFEAALKYSALGADKLILGVRSVEKGQAAKDRILARTGRASSTIVVLSVDLSDFASVQAFIPALESVTSHLDVALLNAGLCNPSYEATAAGWEIAVQVNVLATALMAILLLPLLRTAAATGGTKPPAAAHLTFVNSRGHMTIKDEWLAKSPDKKSLLAAANDAKTWNPEKSYCLVKLLAMAAMLAIAQASSGSASAGPEIIVNAVCPDMTKTDLGRKFGLGARLSMSIFHTIFARTAEQGARSLVSATALGPESNGRFWHHDILHPMGDLASDSTYMEKTWREIVDVLVKTQPNVQQILGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6N1</accession>
    <name>A0AAE0P6N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_517125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6N1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="166" mass="17974" checksum="E079112A827435FA" modified="2024-05-29" version="1">MASPAPSPLAALNAIRSVYLAAFLPSPMFPAHWGMWIPNALDQAVGTLINVRGDPCNGFVHEFERGYRAHDCESRPLLRPLGTAADFPDGPTVPGIDTNPCNDLERLALSIPPPALSLTPAGSSQRRFRVAIKNCQTWLRQLVDAMIEKGLIDPSAKDILDASPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S7</accession>
    <name>A0AAE0P6S7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_491783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3394339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="712" mass="79192" checksum="BBE94229205F8A16" modified="2024-05-29" version="1">MTRIGCPGSPVFLPHGARIFNRLVEFLRMQYVRYGFEEVITPTMYKKALWAKSGHLDNYADDMFTVTSGSPSAEMGEQAAESSEYGLKPMNCPGHCLVFASNKRTANNMPYRYADFSALHRNELSGALSGLTRVRRFHQDDGHIFCRPIQIEEEIGKTLDFIRVAYGALRLGTYRLTLSTRPAERYMGSLEEWEQAEGALKRALDATGQAWTVNDGDGAFYGPKIDIIVKDSDGKEHQTATIQLDFQLPKRFNLEYMAPAPEQERLGIATTDPELRSVEGLVRPVMIHRAVLGSVERLMALLIEQFDGKWPFWLNPRQATICTVNDTEEVMKFARHVHSVLMGTNGDPDKPLYSPSRFFVDVDDHARSVPLKVRAAKLKGYGLIVVVGPRDVQKGTVTVDATGIPQVDGKPGERSMQMTPEELLQFMQGRMHPPPDYITAAASHGMRLRQSAPVKRGPLPLQLPILDFLESKRVILASASPRRKALLAQFGLRNAEIVPSSQPEDLDKKTHTPEEYVQATARRKCLDVYESLLREQEEAETRKAEKAKTDPSFEVVVPADPALVIAADTVIVTRGGHVLEKPRTEAEHIRMLQHLRDTQVHRVLTAVCVVAPKQDASHPGYELGAHLEETRVHFAQADDGLPDDVIEAYVRTREGADKAGGYAVQGVGGLLLIDKLEGGVDNVVGLPVRKTMQLCEKVLFQQGEDEVGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7X8</accession>
    <name>A0AAE0P7X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_62770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="81"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="660" mass="74472" checksum="FE9CEBACA39343E0" modified="2024-05-29" version="1">MVASTKKTRSSQGRKRGQKQQRDAATRRPRQPRKGIPYKYQPLNPSRHEIRLLEIAPGRPGSRVSCRMFPVSLTSSPPAEFDALSYVWGPPRPSYTITLGDDKAFVVGRNLRKALDDLRLPDQPRVLWCDALCINQQDDYEKGFQIQLMRRIYTEARAVRAWIDIGLGLLTGVFEDLSQLAERGGMELADVHDHEYWYPVADIFRAPYWRRIWIQQELILARQVVVHCRRQVLDGEHLFEFQRQAFNSYNSFKDLEHSNATSAVLQYINRDTGSTGVVLYGGGIKRARKLREKANRLLAAAAAADKEDYKQKDDLPASTVNLWLVQLFIQSRYLGVTHPLDRVYGLLGLAADYSEGDIAVDYSLSSTQVYTSIFQHFIKTHDSLVFLCSGEKDSLENTFVGVSVPSWLPSTGINWVNAGRGISQACGAFRAAEGARIDPHTGTLHAQGIQVDRISMAEDATVMQSLPIPDAFSWIERFCRDLWPEATDQTLLHERDEVTDILFPWVGKEFYRRFLHGTTASNRPSPEERLEAIRAVQRAAKLVEDDGQHFSLRRIILGGYTPSDVLSQAERSQALQINGSLTQRMLVGTEKGRIGSMMLPKLAKPGDEIWVFLGCPMPIVMRKTSEKRYFHVGFVVIPCLMNGEAMEGVSDGDIVEVAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVT8</accession>
    <name>A0AAE0TVT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_511160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVT8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="264"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3381323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="617" mass="70652" checksum="4D2C7D009025AC19" modified="2024-05-29" version="1">MADSSAPAPPSEELNNLHLDEVTGERVSKTELKKRQKQRQKEASKAAKVAAAPEKPSSKPKTASGEEEQDLNPNQYHEIRTRHINELLKNPETNPYPHKFQVTYDDSKFEAEFGHLKSGETVENQELKIAGRIYNKRSSGSKLIFYDIRTSADTVSIGTHMQIVCQAQLVKDGGVSFEKQHENIRRGDVIGIVGYAGRTNPKNKLAEGKEGQLSIFATEVTLLSPCLHMLPSVRFPFADSEQRARMRYLDLLWNDKSREALWQRSRMVRFIRDFFHERRFIEVETPMMHAIAGGATALPFITHHNDLDMDMFMRVAPELFLKKMIVGQFGKVFELGKNFRNEGVDLTHNPEFTSCEFYWAYADVFDVMALTEELVSSLVKELTGSYKTQFTDQHGEVLDVNWEAPWRRVEMIPELERATGEKFPPYDELHTDETNKFLQSVCKKMNVECAPPLTNARMIDKLTGEFIENTCVNPTFIMEHPQMMSPLAKYHRTKKGLCERFEAFVCKKEIANAYTELNNPFDQRLRFEEQARQKDAGDDEAQLVDESFLNALEYGLPPTGGWGLGIDRLAMFITNNYSIREVLAFPFLREEKQNPKEKFAAEIVDVQPLPVEGIPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC6</accession>
    <name>A0AAE0TZC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_543349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="59754" checksum="6554D28CAD360093" modified="2024-05-29" version="1">MDIHGLFDANSSKSKPSEDKHKPSVVGFLQSTTFTTWLGLGLCFGLWLVWRVSRHRSFYDDKPKPPHSWWFGHLAIFRATRRSLPFKTHPHAIILAIKQKYKLPGVFFLDWYPIFAPMVIITDPSVATQLTNAENLERHSVVQDVMGELVGQHSVFWSQGQEWKHLRSTLTPGFSTTYLLGRVPRMLHHMLIFEEIAAQMAQSGEAFPILGKLISMTIDVIGDLMLDVRLAAQSEREFDPIVREFRAAMKYTWQGLNFWEKYMNLPGLRWHSHKLDGLLAKEIVKRYRSGTFKAPEFSAGIDLFLKKHDEDRGGKVDGKLDRYCLSELAKHPDILARVRAEHDELLDPSREATIKTLQDNPTKLHELPLTTAVVKEVLRLYSPASSIRTASDNHTITYKGRTYPTKGHANPQLWVVHTCFGRDPNLFEDPNSFIPDRFLARAGTIPPGAWRAFEKGPRSCIGQGLALIEVKLALVVLVRRFDFALAYPPDSPSLPLMGDQAYQVMDFVPVPAGGMPMTVREREHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZD5</accession>
    <name>A0AAE0TZD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore complex assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_472272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="297" mass="33242" checksum="EC0A59E58FA8C4D1" modified="2024-05-29" version="1">MLDYTQFQAAFPTDGLPPYETADLREIETFRKAFNGVLFIDRVLKALGIGEGRVYPPKGANGLRTLHHQVCESKATSFHKLSVLFYLLLDIDDVRGGQSHLADALAEESGLPQTYQILMRGLWHLDRKQFKFAVEHLAHPSLPPSEFADDIIVVLVRHAVANDYSLPLAYYHTTRPLIKRPETLDLLFGALARTSVTEALYFLRSYPEYVRQQLFEMLVASVLDHAEGAGPRGKELVSLPLSCPEEKWLHDYLTAGEGKKSKNAKPIVQMRQIVTGRSRGSVAIPGHSYADAAKVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZG7</accession>
    <name>A0AAE0TZG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_181798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="389" mass="43453" checksum="68961C4CF69906E6" modified="2024-05-29" version="1">MSSEGIIGAFPPPEGVTPNFTNPESIAYRLIIVAVVFPVLSLCFLIPRLYTANFILRRWHADDYWIIAAFIIAVANSIICCIQLTLGLGRHIWDVPARDFTAFMKLGMIGGAATYNLGALCTKISILSFYLRFSVDTAFRYAVYAVMIVAVGYTLPNAILFTYVCTPMQFYWDWSLQGKCIDIQMAFNAANSFNMITDFAILLLPIWMLWDLRAPLTKKMGVALILMTGGFVCAVSTMRMVTAVIGAYNPDITWHYITNLIWCLVEMYTGIICACLPCLKAFVKRYFPNSFLFSPEFEERLTSSIHISLHAMNPVAATRRRQAEERSWGAAAEEPVVDVPKRKQSFDIENIDAVEGEPSNPAPRRAEKQLSGDTLRDASQGAKEQTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZK6</accession>
    <name>A0AAE0TZK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_183200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="41000" checksum="E39669F87C2D2EB8" modified="2024-05-29" version="1">MSESSAPKLPAVPADLTPDWLGSKLGHKIKSLENTRSIWGTGSKLFYTITYDDDDDDKPTTEERPTHVCIKGVFDPNMIEAVPWTVSLAQREADFFSKIAPGLKNMIFPKGLWSATSDKQGLAVMEDLTKTGCTFAPEVAAYPYTTVMNGVEQLASLHADYWGQSQEDHPWIWNNYDPAVKYSSTAWDQVVRLPGRVELPAHIADNTRRNEAVDRFFAERNPRFRTLLHGDPHIGNIYFTADGSIGFLDWSAFHFASCFHDIVYHMTTMLSIKDRRAHEMEILDHYLAALHRLGGPKLDRHHDPEVMVEYRRSFMANLIWLILPDGLQSKERLAVLHERAVAAFDDHKVIDLILSQPKPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0D1</accession>
    <name>A0AAE0U0D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_544451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0D1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015069">
        <property type="entry name" value="2H-PEstase_DUF1868"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08975">
        <property type="entry name" value="2H-phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1868" evidence="1">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="279" mass="31340" checksum="C7CCE24521DAF66B" modified="2024-05-29" version="1">MAISRSTTIFFFLACVALLTLGIVRVTLGIGDFGTSTTTTPRLNRTAAIRYPSGIPFKFDPDGRAQLFRGNTIISRLSNESALYQSLVVLQEKLKRSHNLSRLIAHLPPSSWHMTVFEGVVGIERGKPGYWPSDLSTDATLDECTALFRTKLSTFDLQLSLPQHISVAGFTSTGLGLRLEHKDDKDLRRLRDRLADLLRIRHPKDHESYQLHLSLGYILRFFTADQKAELDKIVWDHVRDAAMPMTFELGAPEFCAFENMLAYEPLLQLKNITSTGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U142</accession>
    <name>A0AAE0U142_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_500607</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U142"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="43"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="193"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="456"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="687"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1062"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3387143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1157" mass="129941" checksum="48C38B2B2E82490F" modified="2024-05-29" version="1">MVAIDDGFEALLEPFYNGKKLTDPISTKEDKYQLLPAFLKVKGLVKQHIDSYNFFVNTELKEIVKANRFIKSDQEEKFWLEFTDIRVGTPTRNDYSDIKTRNDVTPMECRLRDMTYAAPVVVDIVYSRDRKKIIRKDIPLCRIPVMLKSAKCCLNSATNAEMEIMNECPLDPGGYFIIGGTEKVILIQEQLSKNRVIVEADEKTRGVSASVTSSTHERKSKTYVVLKKDRIIMQHNVLVEAIPIVIVLKALGGMSDYEIMELVAGGDARYQDDFLINFDEATKAGVYTQQQALEYIGTRVKMGGPKNRPFNMSSRRSPVEEGLDALANIIIAHVTIEGLDFYPKAIYIAMMVRRVLMASHNPKLVDDRDFVGNKRLELAGQLLSLLFEDLFKMFVSSLKGNMEHFFKKPNRTSTYDPVGPISGQGAYITMGLNRAIQSGNWTVKRFNMNRAGVTHVLSRLSYIAALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCTSDTPEGEACGLVKNLALMTHITTMVEEAAVKRWVFSVGAGVEILRNFSGTEMHKPGSYIIHVNGTPYALTRYPKRFAHNFRKMRRKGFINPFVSINLSEHFSSVHIATDEGRICRPYIIVKDGKSMLKPEHLRLLQLGKASFDSFLVNGVVEYLDVNEEQDTLVALYETDITQKTTHLEIEPFTILGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAYNQLNRIDTLLYTLVYPQRPMVITKTIQLVHYDKLPAGQNATVAVMSYSGYDIEDALVLNKASCDRGFGRCQVFRKYAAELQKYPNGRRDRIGGKEKNEDGTVIAKHAALDDDGLAIVGYQIHSGETMIKKETPIDQSSTGIGTDRGPDEFRDASTNYRIADPAYIDKVFVSNTEKDSAIIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVEQEDLPFSDAGVVPDIIMNPHGFPSRMTVGKLFECLTGKASVVHGRRDYGFGDAFRSHPVEEMGKVLIDHGFSWEGKDYLTSGITGEPHEAYIYNGPIYYQRLKHMVQDKMHSRSRGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMISSDGTEVDICQQCGLFGYKGYCQTCKSTSQVTQMTMPYAAKLLVQELISMNVGVRLQLEDEFPHPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U185</accession>
    <name>A0AAE0U185_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_393063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U185"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="432" mass="49707" checksum="F09AB0CDB2C63AFD" modified="2024-05-29" version="1">MQTPDNSAHYSYIFPIGYSYYAVATSLTPAFYQKLVDRCWRRSGTLLYRPNQKHSCCPHYTLRLDSAEFRPNKDQRQAVNRFNRYVIGESYSKEAARLYPPSREQARKRDNEFDLVARIHGPEAQNLRSPPLPAHQFTVTLEPDTFTEEKYHVFENYQRVVHQEPPDKISQNGFERFLCNSPLKRESTVGLDGTERQLGSFHQCYRLDGKLVAMGVLDLLPNCVSAVYFLYHESVHSFNPGKLGALREIALALEGGYRYWYSGFYIHNCAKMKYKIDYSPQYVLDPEALEWDLLDKEALKVFDQKHYVSLSRERATSDPIESLFPGLNKDQLDEQVAKSKGGDDHDSEEFLFHADMPGIPSLEQMEALDMDGLVLRSDYSDHFFSASDLVVWDTEQISHFGTLKSKIAELVAALGPDLMGDICIDFRKRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1S8</accession>
    <name>A0AAE0U1S8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_493701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1S8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="275" mass="30023" checksum="1FA2567F80C65806" modified="2024-05-29" version="1">MALPAPIKALRFEPYPEIDPNQAHFSTKGNHVVITGGGGGLGSATAEAFAKSGASNISILGRTQGTLTTTKEKVEAQHPGTKIHTFIANMTDKKSVDEVISAAVKASGLINMLVANAAYLYHVKPFMDIDPDEWFRCFEVNVKGNFNLLRAFIPHAAPGATVAEVSSVINFPEIPGYSSYLLSKLAQHKVFNYPDLHVVSLHLGAMKTAMIDKLPEEPPTALPANFIVWATSPEGKFLRGKYVWANWDVTELKAMAKEIESTGEFNFRKRNVQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1U8</accession>
    <name>A0AAE0U1U8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_448702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="92601" checksum="86303391CF6134A1" modified="2024-05-29" version="1">MDASSNTAARAGPKDRERPLPLRSQKDVVPSQSIDRTNSVDSVDSHRSMNFWGRTSTGFSTASMDTTITEPSSPDAATTTFAEPQHLEDTNAPSARPSGSQGFPKPSRASTFASVDLDNLSNPRRTFSSSDNNLIPRHRRLQDMMPSLSSKSRRSSFGKHSAPPSRRGSDHFITPLVSSHPHAKPGLAAGGNSSSDRSASPDLLALHIKDEALNSNILGDVPEESEPSSCIDEHPEAALVFGNLVPGKMAAGPELGPSSQTSHPDSTGEQDMPEPAAHKLDGKLKTDVCDKLLKHLFGVELEDLEVTGTASAAYDAVSYMLDELTHIVPTNSLPSSPFDYNELPTGDACPSNVPIQPHGGGNGGAGSSGGRGSGAPGKRRHNDDDSDPTNQEGSGDNNGGGDGGHNGRKKPKMPEPVDQNLSCPFRKRNPVKFNVRDHQSCAVMSFPDISQLKRHVKNFHKQRSISVFECPRCKRDMRAKEALDNHLAVPSDQICTPPSQEASSSVDPERGITSRIEDCLNGRKANSKIDTWESLWQILFPDDTDAPKSDFVPPIELEEVYVEFQTEVYRDQLSRLFQEEEESSRASDLSHKDPTERVAMLLEIVCDHNEHFFDICRSKTGSLSGRPRRKRNSLGSNKPNSPENGKKHLLTPPVQIPSRKRGGGGANASSSNASSTASSLETNSNGSWANIGQSMVNQSHMEQHNAATIGGYHGSQMVMTSNAGMASLGVAAPATSAIMRPGPLAGQGGVPITVMPPPHLNLDSSNIEQHRRGLQSADSGMGGFNDATGFMHERGSGAVYGPHPDFPPDLEYGQNFQNISAGNGEVDGQNVPPTKKVVIRECQPSGAIGTNALINFSIYLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1W5</accession>
    <name>A0AAE0U1W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7025 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_392246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="1">
        <location>
            <begin position="129"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="45242" checksum="4195749DB1E8155F" modified="2024-05-29" version="1" fragment="single">LEKPDKSWQRWEAITSTRKLAKIRHRLVFDVLGRKTADELVFANGGGDVSDFLESLYSLSSTNRNSLFNGDTIQAEKYKWLFWFKGSIVLHLDDMKNARRPDKDQINTLSTLVLFINHTFNDAERMQGEMRRSGQASYEHLWTLFRPQEIMYEKRLVPPNGATYEQCLRIKDVQDVTTVTDQRNALRLVIEEVVYKCGSRPGPRLAVSRRYIQEFTGTRAITVEGLGIAPLSMLPWEEQEAIRVRLIDRGRRYIELCSKPFSVMDYDGPLRIFHLSTDESLPLYETLNEDLYSICRGHVPAYLLSSVMNAIGVMVSGLRPTTWGRLGGEHLNNQVAAAVKPRIDLGLWKALIGDFLASDGSRSDLEAFQRHRVSGAGLVLLLQGRRKVTHEIARGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3L9</accession>
    <name>A0AAE0U3L9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muniscin C-terminal mu homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_463418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3L9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="589"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="880" mass="95682" checksum="9788357A1F2BE75B" modified="2024-05-29" version="1">MDDLSRSEYPAMLANLQPSQAVNALSERVKRIARVNQEIADWLQERRRVEEQYVAGLRKLLVFKVPNTASELGVFQTPWDKILQSTDAIAASHQLFSQRVEKDVEQALRGFQNKKEMQNIHTISANLQTMARELDDATEKSDKLSKKGGKANVQKVDQATARLESANQQWESQAPFIFETLQALDEQRINHLRDVLTQFGTHEVDQATRAQASAEEVLNTMLEVNTSQEIQNFAQRTVAGKPKLERKTVTRASSVVTGPNLAAPSVSGHEDDVSDHSGTRDGHPESRLRSRIGTMLGRRRQSIHGGFGPLSPPKSLGSFTRNIGSSHGQSLSPRASSHNLTDSQNRLSSLAERPTTAEQRDGLAEKENGKTSHEGTNGVNNEKPSTDIPSIKQSASSILNGTAEDIFDAPPPSGPPPPQQSKEEPTKDSEGFTIPAPMHDPISEAQKEAAAEEADQFFKVSIQKEPIAEEDQDAKKAALSNVANALTHMGIPSRKAGTVRGRRDVRNTMYMPTLPVPEDSSENPFPPSPSLAASSSFTPRPTHSATFASETSHTSDTQSIRSGTSFGGASSYGGITRLKHPEMQGPGYGPGLHSSMIETVSALFQDGILKSAKVAGEIALAYNNDPSSSHPTHETIRLNNFANLNSIGPNRVFVGDSSSPDEFTIDVSHLSVTSPAFTYSVHAENEATLASQCPLVIQPIWKPQADKLGLLLQYRLNPSSTLPRPVTLSNVVFVATYEGARASGVQTKPSGTHLKDKHIVYWRLGDITLTDDWAKIICRVIGEQNAEPQPGHIEVRWDYGPHTATVGDSGRVGEAVGSSISVSRLVESKGKEKAHLESIDDDPFADDKGGPLSPVLAKDTRTWADVPLVKRLVSGKYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3R2</accession>
    <name>A0AAE0U3R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042135949" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="127" mass="13501" checksum="0BD53A53EC905EB1" modified="2024-05-29" version="1">MNTVLGFVVSSLALQALLPGSQAILQVRPGHLIDHRLKAAGQFIVVIRHAAEEKFFCGSSSVTWALCPGEGQGYRPLSTLTAPCGPSTHSSDTPVIAPDIVSHALETMFFDADIGAGIIDYRRKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3Z2</accession>
    <name>A0AAE0U3Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_446175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3Z2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042220984" description="Ecp2 effector protein domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19991" checksum="D495F552CDF7B5E7" modified="2024-05-29" version="1">MGHINALKPFLAVSFCSVVLGAPTPAGLDRPQPDPHTPMDKPDTLPWTSPTHSHGQARHTPTDKPGKGFDPKYKTKPGQPESSDDSDSALSKRVVINGESCVLWLNTAYPYSAMGKLADSAGGVCTAVIVGSRFQPAYDNGERLDGSDVIAVFESSLYQGVDGSTWYDEAYDFAVFVTSGQVSDQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U484</accession>
    <name>A0AAE0U484_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_106267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U484"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="417" mass="47746" checksum="2CA6BF805877157F" modified="2024-05-29" version="1">MPTWKFDASVTDFQQAAGASLPPTPGLATLLEEPAAEQKPDSEPRPPLLTSMSTGEIVNQISKTYTYWEDLPPVKDKGGDRTIALFMPFLAFESHRGRNDMTMDRLKTEKEMENLIKDELRYTELWNPDHTRPLHYRRTLDQYSYYMLDSTERRDWDQVMYRWAKLKAVKARQTFEPDEAPILMVDQLWMWVLPDGTVVTSIPSTQKPAKYSLEKVLEAEFWSKSRHAIKGPESLFSLVLRQCVNVMKREGPCKLNLQESFQSAINNLAESEAVKMKELLKVVKKLKKEPDPFRLTADIDKFSQISEEMYQLVEIVDIQDELAIINSVLTAQKSVLRDLRDHVCCERKPSSTDPPNSIYVMKDQSPPTVAIRKTAVDDSIRIVDENIRAVKEMAESAKRVHTDVSGFVSVCHVLCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4L5</accession>
    <name>A0AAE0U4L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_123855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4L5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="582" mass="63662" checksum="444C05C154AAC6F4" modified="2024-05-29" version="1">MCGIHAVLSAASSHHDISPDLKRRLVNRGPDYLGEATRRVGVGGAWSLRFTSTVLALRGDHVAHQPLVDSSETGSVLCWNGEAWRLGGQPVDGNDGEAIFSRLTKASALSPTVACQERDDIILDVFRGVEGPFSFVYFDEPTETLYYGRDRLGRRSLMVAESDDGTLILSSIAKACDPRWKEVEADGIYVLRLCSQQPLLSDDPAVSSSPHSPVLKHDWLAGNDHADFVSSIGRFNNSLPSAAATAGFALKPSSPSVGMLKQQLVDSLRLRVLLIPQPPLCAAADVTSRARVAVLFSGGLDCTVLAKLTHELLESDQEIDLLNVAFENPRVIAQLEKEAKPGEVVDFYEACPDRMTGRKSFTELERSCPGRTFRFVAVNVPYSETLAHRHQVVSLLYPHNTEMDLSVGYALYFAARGKGFCANADPTSTSSSLVPYISPARVLLSGLGADELFGGYGRHQVAFTRAGYAGLADELLLDVGRLSKRNLGRDDRVMSHWGKEVRFPYLDERLVRWAIETPSWEKCDFENVDDAAGVKAGKRVLRLLALELGMENVAREKKRAIQFGARTAKMESGRVKGTTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7F3</accession>
    <name>A0AAE0U7F3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_27160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7F3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="24638" checksum="B827FD5D4F3D9000" modified="2024-05-29" version="1">MTLYYTLVFMLLMAEMALFMFLVIPLPFAARRKMFTFISENPFVAKLQYWLKITFVFILILFIDSVNRVYRVQVELAAATEANGNSGAAIMGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYIMILEVLRLEERVKQYEGTEKNTKQAEKLAVAGEPGEIARLRKQLAAKEQDVETLKKQAAGLHREYDDLSEKYAQTQVDDLPKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Z9</accession>
    <name>A0AAE0U7Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactosyl transferase gma12 mnn10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_31481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000237">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="517" mass="59162" checksum="1FE262959E4185E8" modified="2024-05-29" version="1">MIIPTIRRPARVASVLAVLFTVWLFLFAHSFPGYQLPTDLLQRTANHRPAFWSSTKKAGSGATSRIAKVTVAANKLDSDVIHRALLTHERHNALHGYQHHIAYQEAVSGLIENDRQRRPRGAWTKPAYLLSILVSELQKPEEERLEWVFWFDADTVIMNYETPLEIFLPPANATGVENVDLVITSNWDGLNSGVFALRVNHWSVSFLSAVLAYPIYRSDRLATDRFRDQSAFQFLLQNKTHSPLATAPMRSKDHWVEVPMRWFNSLPVNNAFYKNGTWLFGKNMTSAMFDNGTTKVFDDGHGGAARPWKIMQGDMVVHFAGTSHVRDSWMEPWVERSEAALPQWNNATHLIPLKEQISEFWAKTDEQMEAERKKYAAEEEKRKKEQKEKDKLEQEKKATEKAKKEKEEKDKKEKERVEKEKLKKEKKEKVLLDAKKKELQEKQQEHAKLDDEERSAGEVLLVDTSFAKTDAQPSEAKTPAAKEETEVAREEAAAAAPPVPRFALSNQTTPATPLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Q6</accession>
    <name>A0AAE0U8Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_52910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Q6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="280"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="558"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="930"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3394629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="979" mass="106942" checksum="5F3DF7B8C518650D" modified="2024-05-29" version="1">MSWTTLVLAYLLGGITFLPLVLVAALAHAHFTFPVRDDADRTASSAASDLVQPGDDLDALKAAQKDDAKPRQNHHDSDVAAGYFAVCREYTPMGINAKPIERSTPVGSTTVGAPSPSVYQTMYRSIFDRKPGPGPLDNKANTSQRPKKAGNVFYVVLRHGHLMLFDDDEQLEVRHVVSLAHHDISIYSGEDRTPEGELFIKRNAICLSRKTDSVEVAPDSQLSKPFYLFSENCSAKEDFYFALLRNQEQSFAPGNKAPSPMQFDVKNIISLVQKLHSSEEHMQTRWLNAMIGRMFLGVYKTKEMENLIREKLTKKISRVKRPAFLSNISINGIDTGVSAPYITNPRLKDLTVEGECTVEADVRYTGNFRIEVAATARIDLGSRFKAREVNIVLAVVLRKLEGHMLFKIKPPPSDRLWFSFQQAPKVEMAIEPIVSSRQITYTVILRQIENRIKEVIVETLVLPFWDDIPFFNTEHKKWRGGIFQDDTVDPSADLETTVAQEGDMDEVERMEGNGGIQGPELPSTMEKSHSTPMLQKKPSTGLFGRKLSNKIRAESASLYSASSTSLEVKNDARTESKSESRSVMSPALAQPSTPTIETDNTHADIFKPSTSPPNESPAVSAMTTLSARSQNSSPAQTPNLTPFKPYVTSKSSSHSSSSSREAIDTDKDIEQTPKPRRDTASSAESHEDNATKSPTTSGRGSIRSQAGSVRGFFARHDSALGSSPAGSPGPNDKRNTLAAVTNAAATAAKRWGLNALQRRNNEGGSGKDGLATSEEPPVDIHQPMGRGQPLPPPGMPLPMPSKKTQTAPIPVPKRRPVPPPPPTHHSEAPEPTTERRHLAPPPSHASHGNDAAGHKAERRPVPPPLPKRRQVQREQSGDEDSMLVVAAPADSEPTTPLSGSHSPSYMRPWVEDAEDTTGALGISDNKAVVAGHEDQENTAGKAELAASDDDDDEYSAWMDNPGPDELFEPAPIAKHETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JWK7</accession>
    <name>A0AAE0JWK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_530070</name>
        <name evidence="1" type="ORF">B0H63DRAFT_530075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000028">
        <property type="protein sequence ID" value="KAK3365390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000027">
        <property type="protein sequence ID" value="KAK3365394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JWK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3365390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="65" mass="7161" checksum="5138DA15CFCC5540" modified="2024-05-29" version="1">MTAPFRDAKSGMNTAWSQVRRAFDRGGFAKIRLKGVNYKIDVTGGWALDNGRAMDRLLTAIATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0D1</accession>
    <name>A0AAE0K0D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_85110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0D1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="233"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="792" mass="87714" checksum="51C6B9D98A399DCE" modified="2024-05-29" version="1">MESALAAGVPRTGSCCPRCSRMLREVFTDEALSLCELDNPMAIKDSSSDCAMCSQVWNVMQSDLVLVDQLRKYADSTFNPTSMYHDDGISDVEEYITRTKKVSFTLQLNLKHEEGRQGSVMILKLAAVFGTKGTSRSLKENDRSVQQVFMPFSDLSRLVSTHTISPDVRLNAHQKFALMDSWLRNDTQSPDSTGDAFMPSRILEICGNGVVKVVDTLSSVRAFEDQHQVPFVYIALSHRWGKSQHFTTTKFTLEDRRRGFKVEDLPGTYKDATFVARNLGFKFLWIDSLCIIQDDADDWRTESQQMGDIFRHAKFVIAAHCADADKEGFLARAMRSRDAVGIRIDSRAPFSLYRQGNLAMDVTGSPLSKRGWVLQERFMASRTIHFTDGQIFSETTDELLCEDGSLNTHDLGTSDMRQSSSTQGLTTFRSPGSVPQLRQIFGLGSSLSIAPKTSEGHLSVPLEWLDLVEMYTNCELTKQSDKLMAIAGMARKIQSRTGSVWCAGLWGDILAPSLLWMLGSTKREIRPLPSTAPSWSWAAWDGPVHHPETARKFTPVCSLVCVNTPRDYTQATRTTWLDGPGTLTLNAAMVSFPDGATIASYSTELGPGPARKGALTDGTGALGPVELNQFIRARAITTSYPENEVLGWICIDDVAATRLNFEQSYWNTNSMRQPPPNPLHPTARDGNGEPTQWGIKELRFIPVGRTRTMRPSLQTIPATCLGLFVVPSGGAVGSSSYRRVGVGQVSARHLKGTLVPRKGPLTAAELLRFTRRIGPLSLETFDPWPVEDIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0P6</accession>
    <name>A0AAE0K0P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_442549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0P6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="382" mass="43728" checksum="519B92679BB69784" modified="2024-05-29" version="1">METFCDRNGDPALKLSVLDPLPPSAKDALCNHLWANLHPATSQRLHSPNINLDAYWTYYHKECSNALHDGGRHVATRTHNDIIECAHQLQAGMLRDDIKTLLSSKLSTEHANKDEMLDNSVDLAASLLLMASFGTFSYGFSGKSRVCWNTPTSLRDFLATYFEPEPKSTFANNSNETVKLEKIFKASNLDRIAGLEIVWTDNLVDHLRLTDDDTRVHIFHHVSFLNIQRHNNTGLLPGGLAEESLQTLALLFPSADRETKRWFAKLPKSDNVLDAQLLHCGRLKTDDRQIDRFKFWRERLVMLKQVFDEAQPGTMGQWWYDRRNGVQWYTFWVAVLVLVLTIVFGLVQSIEGGLQVYYSHQALHTSELDRGLHARRWERMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K178</accession>
    <name>A0AAE0K178_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_83018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K178"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="67622" checksum="E0BB1C5852894F95" modified="2024-05-29" version="1">MTVPSNGSVMMFLDGDHSGDSSAPPLTIDTRLPRAERAQSIHEDEGQATVELASIMTTASNPVSPGPSSPPLDQVMPDFVPPTRPSSTPFPQPEPRNTDLRCISCPTGTMMNMDEPELAGQLGQVPPPREIMGMNLNGFPAEIHECILDHLFGFRVSTASKSSIMRWGTALRHPRRKELSELSLVSSAWRVLIQERLYRHIKLKATVESLRESFVYFSAHPHLRPYIKHIEIWFPVFQPKYGPLALSTANTLPTVTADGLTNASYILPVDNCSLEEAFYFVAEAFPEVCVMTLEGGERKKAPKVRHWIREADHDPRLRIMPKIDSIRTLICKGQWNLIRGEEDFETIASALPNLQEWHGSYSKPKSKSYFTMAEILARPMRLSTLNLCIEGDYRRELAFPPYFLKVSNRLHFCSKLAQAAASPSLEHISYTGRVCKQFFIDLMARQRDPRQARLKSIDLTVKNCCRQVTDWNESGSGITDMNFINSFEALVLAGIRALGKLKAVEYLRIRYVDLDSPVPPLNPYFILRNGWCSGVWSDAIISELNRVRPTTRFEDLAESFGEIGYNKDGRMTISPDFPKSKALSLKLSNYALLSGGISISQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1A7</accession>
    <name>A0AAE0K1A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1A7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="756" mass="83916" checksum="8E0E4CE0D879C722" modified="2024-05-29" version="1">MAVCALDDRAAAAVHYRKYVPVLNAIPVSSQSSGIRDLPEAEGPGYYLVIDYITEEIARFLAFGFKNPSTHLHVITITALAKVSAKMKVLSHRIEAFAKQSFDSSTDLDSEYRRQERRKRTRLDDSGQPLVINNKLYGYEEEESVVIKSYRRHHHCLSSHPDASDLELEYEDTQPDEGPILRDFELFADISDMCHATACIYRILWHILEDLSARNIPGRSPTSSTCAPSSTAPAPTSTPRSCTRAAFTNSRALLRASLSDWASTRLTNYSAIPVTLSINTDGLHQTAETVQVISIPDLVAAIVALSFLNPSVLSAVIQAYIATRRPAILQRIAPRFGSRAMYGTFASLQSTPTARQVRRQHEVSLEHTFSLVPSKSLSRSFLTNLNFLLDEAHRKTHMKVLRQSSTWATDETSITVPFGTRIEGVDPFNLTMFAWIIAGFSVVVAKGLRVRDWPWRDFIAGRVTCCSVGELANVTSIDPQGIITHLLALEDEMPLVTRGPYNSVLSHRGDGGDEGFSMDVQITIGTLARSGMLVVEVVTTDRGNGFGSGSALVCLDLRPDIERGADHGDWASTRHSREHTTHISHQQEDVQILACMNPPGECEPGSEIVLRWRETGWEKIVGVHDDVRNKLFAISRKNHLLRYEARAYAYTSQSPRKFLANCIISPTGRAASKQNDQGYWHKNLDMTRRCASWSRGRSTLRYRLGIDLLETLPPARRPPGHLTQGTSGGRPSILLLTYSGMVTLIPRLLAIPDADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X1</accession>
    <name>A0AAE0K5X1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_528389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5X1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="283" mass="31503" checksum="6BF68BB4109894DF" modified="2024-05-29" version="1">MRRSPDCCAVLHGYYNIVKVALMREVNPNHCVLIRTNTNWSHRPKGKAHRYLDVELNRLAKAKVLPQPKDMVIILDPTKATTADYDADSKNQSAKRIIVTCAIHLAVYQGHIELVKLLIEHGARLDTPCRLPMLASVAQSVDGFRQRGTHILVTPLYVAIARGHGEIAKLVLHHGSPLNLCLSSHIISPLHLAVTVKGREMTELVLAQISHTSRSLSQLDCDGFPPMWLAYISGNFAALQVLQKCGQNIDYDLAIGYTLLVDACSWATLLPPKFWSTLVPVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6H9</accession>
    <name>A0AAE0K6H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="118"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="575" mass="65079" checksum="2458C9B7F77188F2" modified="2024-05-29" version="1">MAAACSFLPIPEFKPLTPLLFFCQVSHGMELIDRHPQMRGVVLGWFGPPAGLNSCPADAIAQQAFEAAKTRIADELTEKERDAISNNNSFTSMHDFTTTLSSARSQYESKKNSKAYVWLEKLSSRVVYYGGVLDVLVQHNPEYVSLVWGTFKFLFTSVLHHEEMVKNLAKSCAYIADTLPRADLSLILYPTGAMREAVARLYAVILRFIVHSVRWYRQSRLKHILTSITKPWSLDYEPELREVEQHARSIDNLAQSGSQAELREAHFQIHHIRSDLQVARGEIRWLTEFVEDKFQRLIEFASANQSLQHRISEDVASSKQMISHVQLGQILSLSFMESLPTSGQCLAYCRSFWLRRRSMIQGGANISASGTIALQKITSNSQQQDLSFLVLENRSPTQIKDFLLGMINLLHRQRLPVLWALRSPNLHNSSITSIDVIRMLLYQALQINSSALSTSHPITIAHLREASSHEDWLTLLKRALDGLPTVYMIVDPDVVQHVTNQDKGVATGLLVEFVRVLGPNKARFVVSSHVFEVGQAERQLGRDAVVALNTEGPRPDTHAAIRRRLQASQRRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K786</accession>
    <name>A0AAE0K786_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_487326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K786"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="501"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="718" mass="82279" checksum="A3E55DCF3AFE9B19" modified="2024-05-29" version="1">MNTRRGPPHPPPPMMMRPRHHMHPPIGEPDDDEQKEMTGHLSDEAKARRAELEKAPMQAELKYLEKRYTKKGRLYVTEPKEDEDLPDQSINWHEKFVLCVTRLYDPQNRYVTQTSLQVNSPALRNLLRDVVGYYPGQSFHTSAITIDFPAHCLYFCRNKLRAVLDEQEPGSDLAAHLPILLEFINEQHKDAIKEGDNFRAEGLMSYEHLWTIFEPESLVYATRIGQPRIYKLNSFQYVDNQCAALELNVDYVDYDGTNFGKRSETLRIPKFKGTAPIAGLPVMPLSFHPDPERVSRRVIARGRRWEKLSGQTFCEYKGVAREYVGTHENGDRQENKFNIEGRVMVDTHTYHRIEADQAFFVERPFPAVGEDATPERPNSRKRRRSVDSEYESDSDSDSEAEDWNLVPEEDVPKRVLAPLTDDQCLLATSAVRGFSFTEKKFLEFSVDQLRDVEWNSESFEQLVLPNQQKELVQALVAEHTQRTTTTNAGKGLEDIVKGKGLGLVLVLHGPPGVGKTLTAECVAEFSKRPLYTVSSGDLGMTAHTLDEKLTRTLDLASTWNAVLLIDEADVFLERRSLHDMDRNALVSIFLRTLEYYSGILFMTTNRVRTFDDAFKSRIHVPLKYEDLPTESRLKVWKNFLGKLEGEDGGVDIDEAGYRSLAEGRLNGRQIKNIVRTAKSLANYKRRRLDHDQLKQVMDIQMTFEAEMNGDDDVDVVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K792</accession>
    <name>A0AAE0K792_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K792"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="15407" checksum="930C94678BD1C80E" modified="2024-05-29" version="1">MINSFGIMKITINEYNRLQKEYGGYFDSNLLDTLLLNSKPDSHGFTLARHPYIMEHMKKCGICLEVYPIPNKIPGLTPRVGGHAMYNLLANDVRYTVSSDNRTLFRLRHACMTEKEFRSVKEIWQGMWDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8M5</accession>
    <name>A0AAE0K8M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_290051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8M5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30293" checksum="2C011C5651A16471" modified="2024-05-29" version="1">MHNGHHVCTVDACNWAEIDSTKVEQLHKCKARSACTTYKFQADIVERAVWSGGSTAWSLDRSRTWTHGERYAAISRVRSDGTGVGVEWGDDKDKVNTCLYDYFASIVANEGCGGIWWDTISLPMEPDARKKAISNMHLNYASAEWTVVHDRYLLDVDWRNDSTHSLALVLSPWFTRGWTALELAKSKTVKVLFKGDHPNRPIVKDLDKDILAADPACSSRAHWIASSLIRRLRKPITGVSDVNNSRPTGYFMGAGPETHRRLSRGVGCGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8R2</accession>
    <name>A0AAE0K8R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_453369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="617"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1321"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3371989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151333" checksum="80F5F978CD1DC3E9" modified="2024-05-29" version="1">MADYQQDRVPPPRPTQYGHPNNHERDAAFSHIFGAAPPPGRSQTMTSSSAAPPPLMPYHDGRTQTMSSTSTAIPRQPPPRLPPQGYASPTSPPQRQNDGAPAGYYQGPRSASGGQQVPSPQYLQQQQQFHPQQPQPQQQARRPYPPAHPSAQEQEGSYYSNQPQGRPPGPPRGDSMRSPPPGQQRLGSPPGQQQRVPPFDPMRSPPSGQPRADSMRGGSPPQGYYNNAPRTPAQRFYEGGPAPALAADPYRSQSMASIPRQPVYNPPPQSYQPQAPANTFRHAQYNTHSARTTAQGRVVPERHPDDRSMSMTGYTSQDRDSHQTMSGRVIPNRRVPGASPTAPDYTSGAAGYGGPNGAYPAGYAPAPGSQTRTTSMASSTSTDNTRTMSMASTIAPSIAASDRTETQTLVHRPSAAGSSNSDRPPTAKIRPPIVYPALLSRVAECFRQKIVVGDRTKNELTYKNAFSGAEAVDVLSFIIRTTDRNLALLLGRALDAQKFFHDVTYEHRLRDSTYEMYQFRETMTEETEEKPAVNGVFVLLSECYSPTCTRDQLCYSIACPRRLEQVSRLNLKTGPGLKKEGDATMNDDDVDKTDEQKLWINSVPKEIADSIGDREKKRQEVISEICYTERDFVKDLEYLRDFWILPLRGKVTGTSVIPVQRRERVVRNIFSNIIDNPSIHAVSSRFAKSLTERQQKSPVVQCVGDIFKEFVPQFEPFILYGSKQLEAKFEFENERSINKEFMKFVDDVERRRESRKLELNGYLTKPTTRLARYPLLLENVLKYTEPGSPDIKDIPVVLGQIRDLLTRVNEESGKAENRFNLRRLHEQLRFRPNDKMDLKLTDEGRELVYKSQLKKTPGEQSDITGFLLDHAVVLVRIKQVGKTEEVKAYRRPIPLELLSIKEMEDLVIPGQGTVKRSSSSLLPLRASNDAKKAEGFPITFRHLGKNGYELTLFASNSLGRQKWLEFIDAAQQRLRARADFLNTTVLSAGFFMGQNKVNCVAPFDGGRKLAYGTDNGVHVSDRKFKDKDAAPRTPKRVIDLPNITQVDVLEEYQLLLVLSNRSLYSFPLSALDPNEPMSSKRGKKIQSHCSFFKTGICTGRHLVCCVKSSALSTTIKVYEPNDAMSRTKKQKGLSKMFNAGQDELKPFKEFYIPTESTSVHFLKSKLCVACARGFEVVSLETLETQSLLDQADTSLDFVARKEGVKPIHIERLYGEFLLNYSEFSFFVNRNGWRARPEWRLDWEGSPQAFALSYPWILAFEPNFIELRHIENLSVHIVPHKNIRMLHSSTHEIIYAYENERGDDVIEALDFWKNQRKSEVYHNNTSPRSDIHHASPPLPGSSNRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDP7</accession>
    <name>A0AAE0KDP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">B0H63DRAFT_261612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="48174" checksum="B25C5C93E7A22F5C" modified="2024-05-29" version="1">MTFRALNHAHIAMEETKPLARPCAKCRAQEATLDSRSQAVCSDCFAKFISTKCIKQIAILGKETRVPGHGPPPPNTAATGDTTSARRYLVGLSLGVSSSVLLQLLNENIEFQLARGRNAPFELTIVHVDASSSLSLGSQQQQSDNAAEEILSKYRQRYPRFDFRCIPLSAALSLQTIDWTALTPLTLPDSHPSKSPAGRLSELFDNLPSAASRTDTLRLFIRHILISTSRLERCQALLLGHSTTALAELTLSETAKGRGFSLPWQINDGALPVVNYSSSIKTNSPEVPAATAAAAAETVLIYHPLQDVLRKELTTYATLTSPPLTALISDLQDKTIATSSSAVVSHKDLSIEEVMFRYFAEVEENYPSVVANVARTTGKLLRLDGTAGGENTTTWCGMCSMPLDEQGDKRWRGELGEEEKTTTTANGTAATGGRLCYGCERTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJP6</accession>
    <name>A0AAE0KJP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_399082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJP6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="63" mass="7924" checksum="43C94DB6C9D2496E" modified="2024-05-29" version="1" fragment="single">QREYSCCHFRWIELQWCRLYETTHKRCQPNVTHFEYRADDVCGECQPKTYPPWENMIKRNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJS9</accession>
    <name>A0AAE0KJS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_231189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="672" mass="75699" checksum="8C4F42E8DF8387DB" modified="2024-05-29" version="1">MLQEPPCASLFVLCLMENLSSDALQWEQILSSPQASGYFAMNWTGGTIYRQSRTRLRKPDPSRQRQQEFLKARARAAKQKDSTDREYQPGTFCRSSSSLSRQSRASNKSGHSAGQHAAQATARPSSEQARKRPRVLASNPGDFPLPTPAQFMEHYNARERGELPPLSERGQKEYNRNVKKALAKEDPWGFRLKRPASPTPPKKSRARRPSGQVESQAKTGLPPHIIRDEKNILRCKLDPRTDGIRREDVVVRVGSQEKRPLVSSSAGRSHAASSVRMPPDNERHHASGKTSSKLQEHRRHYSGDKKGSKVEDNGRHRPADKPSSKKNPGRSRHFTAPREEKRLHEHHTFPAAQVYEESLGNEWSQTTRPTTSPTQPLVTRISFPQLHAPIPTRRVVSQSLHSFKSFDSENTNSVLAQAGRVVPPVPASQKGKNDRWRTWRRESSSPIDNDEAVEGSWQSVEGSVPSPGVSLRSRPVPEPDSEPRLPNLSHLTRTVRSKHGFDKSQNLPQVLTSSDSSEILSRYEEMVARLRHLQEQSKPYEQSGPYPGSDSPDQSESRESDEPHFLEHLPSPNDSMDFRDKKDNTSFRPSILPKLTGQTDADLYENDNPEQAWKLFVLGDDRTDDVEEAAYNEAKRDVARSLQPSDCSTCVGNNTSVSRNSWHRVHQSGWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK97</accession>
    <name>A0AAE0KK97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser/arg-related nuclear matrix protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_225330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK97"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="105325" checksum="4B2CD50B1990C897" modified="2024-05-29" version="1">MVETDDIQRLLQTGSWKTSRSRSPSFHNSPERAYQPSKPNVKVKRPPRPIVEDEVVSLAKEYGASVVSEESSEDPKHPGDVDQYPILLPVHEYNPERRFVILSDGEKSAGTTQPPTTEYEANTCRKYVIVSPEENAKDGEKRPTLSKPKSHSDLPRLRTDFEQPEAPIRRSNSRRNPRDKALVDQEPRDHTSRRENARPPEDAFLSPVYKQTTGGRDRPYREFDTAPPRSPARSPSTRGEAQIATSEDRRPRQPPPSQPTKPGPHRRVSSATGAPKRHARTPERPNHSVDAFPPPFVDSSEPAVRSLNDGRGEKSRSERPRSSIDPFPAGYSFNDPEDIMNFMMPGNVAPRGERRNISPPLGHQKSNSPPYPVSAASSKMPSRSASYRGRRPSSSSRERDGYSSDDGQRKQRSDRPDRARTRQRNTLEPDSSSYLMPDPGQPSNPGRSKANPSSPLPSPRLSQSGPFLDVSAQSIPKSPKTSKSSTFPTEKNRRYDDRSVSPAAHDSRSPPRPANTNSGRNGTASLPVPIPLPVDRGSSVELRAATPPYPTHGSLDTNSTSLQWQPSPFHPDEYKASLDRPIESFRRYSEDVRQGLVAKLPDCHWTTPSKVGNAVFSTLPRAPNFLICPGCYSGIFAESRFSRSFVPAPMRSTEQLVFCDFGSSFWYRIAYLMTIKYQYSDLLLLEHIASVAKRHQPCAGPQYATRTWYSMQGPNMRQPIASFSVCPSCVKMVETLFPNLSGVFVPLNAQADWDVCELHFTPDRKRFIQYFDLLENTSDEAHNRKSVPDVTRLADSIRDITLVDECRRNAPLRDCKWYVMESIPDFTVCEECFDAVIWPLLESRNCGDIPRNFYKGKQLKTVAACQLYSDRMRGIFKDACYRNDIGYLKAAVKDKFRLDIQIRNNLTELARDDPNDPWVRGEMARLVKQLKENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKU9</accession>
    <name>A0AAE0KKU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_480356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKU9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="108827" checksum="DD550567BA2DCB70" modified="2024-05-29" version="1">MSLGIHKLWEGLLLAARRPSLIPRGARGVTVLSSAVAISANPHPKSTQTSLPTLTSTSTEIETETNIKIKKIEIKKIEIKKIKNKKIKIETKGCQVYRHLKPDGTLTVPLEPWTDKPATKVFRGAHIAPIPRPPPTFRVLKPDGTIKVPIITRTINKPSTLLSGTTAGLQRPSYRASRPKIPGTLSSTVSPRTTVGREHQDYRVLRPGVSGTLSSLVTRPAYKLFKPKDTYRLLRPQGDKLVCVPNPKPSDVALVDVSRIIKPKQDSFDSSKTKSSLLDRLAKIPVRSHGELESVFVRPATEFTNEKETRRYVDRRRREVMGQLRMAARRVARHEKDADWRQVLTTLTLETPENLPSRIDSVKILFPRDSAKLLLSESGDGVWDIKSRTGVYMHFFPGSKLEDAYILLSGDATAVASAVQDIMKITKNVTVTTILGCTETDVHTASEEQAPDDSGDYSWSLMSVPSHRVPNPHTPFFSATPASEIARPEEWTKTSFESYVAALVLSRLPRGVHLAIYGAHERHQEAVARELLDAFKDPAAQHAVTVSAFKTALAFLVREAETTFKRGVRALMGRISELGLPTDSDVSNILLERAVKHKDLFEFRRGIRLMLRRGHHPTFRTWRLFLRMFEAEDVKRYILHAMQSKNLIDGQAAVIDVAKEMAKHDAYRAVQLDQSLEAFVASQDELYGSGWLNLWSGNFILEVWGCYGKFDHMLGLLETMLAQSITPSTVTLNILITHCKLHDEVDIAIRFLSILESHGVEPDDITYHLFFHIAWKFRKPHMISVLWRLGCLNTSLTYNMRRRIKWILNNTDGSLDKLALQLGINPAEDDVKAANQDFMQTFVENLFLGEYQEATGIKNTDMRKTTTFGDLLGVMRWYKQRHVPTTLLGESLRKALDRDREIQSMSREGKPPPSDAIDVPTRDRLQPGYAVPFADWLSRAMKSEVDEISVVEEGEEGSHELEKPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLZ0</accession>
    <name>A0AAE0KLZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_245634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="406" mass="44420" checksum="19BC8EF277C939DC" modified="2024-05-29" version="1">MVRNIVVLGGNSHPLFVDRVCEFLGVQPSKRVLNRFSSGETRCEIQDSVRGKDVYIIQSFGVGTGIDHVNDYFIELCIMISACKTGSAQRVTAVLPMFPYSRQPDLPYAKAGAPRDTFESVPATPASSIPRTDGLTNGVEITDVMMTRTSKNGGAQTPPPTTTHQYTTHDYENQNLAMQVQARTGYKHWVAQAGSLVADLLTCAGADRILTCDLHEGTYQGFFDIPVDNLYARPLLKRYIQQNIENWRDAVIVSPDAGGAKRATAIADSLGLAFALIHKERRPTRITDRQKATMMLVGDVANRVCILVDDLADTANTITRAAKLLKKEGAVRVIALLTHGVLSGDAIARINASALDAIIVTNTVAQDSHRRALCPKLEVLDISPFFAEAIRRVHHGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0A7</accession>
    <name>A0AAE0N0A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_405581</name>
        <name evidence="2" type="ORF">B0H63DRAFT_405582</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000017">
        <property type="protein sequence ID" value="KAK3365458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000016">
        <property type="protein sequence ID" value="KAK3366331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0A7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="72" mass="8018" checksum="CC8A6B3CBE7AA2F8" modified="2024-05-29" version="1" fragment="single">VTGMGSCLGVWSWAWDVGTTPYAPPEFEDDPTLPIVGYYPALIILTAIMAWVWVVVAWVGMKYFRHARVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1V4</accession>
    <name>A0AAE0N1V4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_84907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1V4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="185" mass="20369" checksum="1866C2E8E3E7FDFC" modified="2024-05-29" version="1">MAGGIAEPRGTMQVLNTPRQTNNTHPSTMTMSRENPILSWTRMISACKIHGCRPPRHPSQQQPTARRPCCSTTPAPVQMLLLEQPLRMDQYIVIRLAMRLTTYLSALRGAKGRRNSGRTKINGPPGLFSLRRRSRLLKSPRGLTRSASRTLRPSQRALDALEEIGLPSDLSAGNSGERGCGGMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2L0</accession>
    <name>A0AAE0N2L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="24268" checksum="9BBA9D6AEC39BCD6" modified="2024-05-29" version="1">MWLLTDPFPHKFVNKLGVSTLFLADSLNLTGFVSTAHVYSVVSPCKIANESYVATILTHVDGAMGFTPVYALHADQFEDVIGAPLMEAYNVQNHGAIPPADPPVNMTWTDGLNAITRARYPESQRRRAVFEKWFNHAILPTNDETRSEPPSTHLPHPPNTAKTDNAPARLTDGWHDEVYTKYAGHRQIVVPVGQVEYWSTYTRRIGVPACEGCAPGGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3L5</accession>
    <name>A0AAE0N3L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_487867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3L5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="24427" checksum="D04A6D9EDEF6B5A9" modified="2024-05-29" version="1">MPNNNSSRGENECQSRTAAPTLPTDDSSQQLATRRPILPPELMAVLVPSLKVGATVGGLGVFAGAALGIARSAPPALYGLATGGQWFVLSSSFYGARLVGLRVLRADEEIRPGDKTAASAMAGAFAGTVAGSLRGPKNIIPGAIVFTLLGAGGQGLANIFSRKGDPDAAPKKGFLESRWSPVTPLTDQAYERMLEEKLLRVEADLAILDDHIKAVQAEGKAASEKSSENQGSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4M9</accession>
    <name>A0AAE0N4M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_307240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4M9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="22743" checksum="718F151B8B157CDA" modified="2024-05-29" version="1">MGPEIHSTSQDAETKPDRKKVPASSVFAQCPDMGALCSHRRLRKMTLPVSGRPTATTIQSIPILSIFSYSHPRSPLLLGDKSRKLLPRHCTATFATRCYGQFSDHLSRAATEMLAQGHTRTIETRQRASLLLYCLRQNKIDSFRSAVTSFEPLEPPPLPPLLLFPCHVETSQWLVPTALVWRLLFLSFLSLRLQTLESQFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4V3</accession>
    <name>A0AAE0N4V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_313048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4V3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="35948" checksum="B7024CAE2076768F" modified="2024-05-29" version="1">MANVMKAVEIKGGKGHADALFISPATPKPQPGAGQALVRVKAFGLNRMDLIQREGFYPLPPQAPSTLGVEFSGTIESFGPGEHGGFQAGDEVFGLAYGGAYAEHIAVSSKMLLHKPSHLTFEQAAGVPETWITATQALHFVLGMTEGKSVLWHAGASGVSIAGIQLSRQAGAGAVFATAGTDDKCLFIEKELGATAAFNYKTQDWAAEILKATGGKGVDLIVDFVGASYFQKNLEVAARDGRIVLLGLMGGRVVENLDIGALLYKRVRVEGSTLRSRDEEYQGRLRDKLKEYLPKFESGELKIFIDTVLSWEEIQKAHGLLEKNITMGKIICTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N505</accession>
    <name>A0AAE0N505_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase T2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_317514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N505"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042117886" description="RNase T2-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="160" mass="17171" checksum="5B41D4CE431427CF" modified="2024-05-29" version="1">MVSFTSLLSLALAAGGLAAAKPTSFNGTGQIRTLWAYGDHSDLGCLTSAGLWTTDESLCGKFDAKRTNESPVMFTLASVEGPCQIYGKFSCAKGNEPYIFGLWPWGNSVPGVECLRWGQYGLMASSGPRNPPLPTDPPQELHLTSASEEQKYVWLTFGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N544</accession>
    <name>A0AAE0N544_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_564736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N544"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="758" mass="82218" checksum="19807296AB151B45" modified="2024-05-29" version="1">MKPNGTANGAPAFGPKPLKVVIVGAGIGGLTAALGLRQAGHEVTLLDSSKFSQEIGAGLAIAPYSNGALKRLGIDLETIGGNENTNTYIWPPFAPQKIAISFDEDKKRWQHRRVMVHRAHLHTALREKALSEDGAGKPCTLRLSSRVVSVDAENGEVVLESGEKVTGDMVLGADGVRSECRKALEGGRGYVPFESGISAFRFTVPMQAIRDDPVTAALLGPEGTLLAALAVGGIKRLICYPIVNNTLMNFVFTHASAESKADDQSPENLKSLVLQVGSAFTPAFQAILQKVQNDTIRLWPLFDLPALPTWVNGKMAVLGDAAHPFMPHRAEGASQAIEDAVSLATIFYLGTPADAVPERLALYDRCRRERASKIQEASRIFSQSMEYQAKKGFNPHVFDNYSFSHDEHHHSLQQLRLLLKSKHPKIRMRMPMSFGPAAGPCQPGNTIHGVFGSKPSDFSPSQVVHTIRFATSKTYLQNYFPTPAFSFTKADTMVQASLVCTSFRDLAWLGGEGYERVGLHIHGVQYKSPTTGDVIKGSFVPVLFENSLDSIVTGREERGAPVMGCEIDIAESSDKKEIALRWKDTVFAQMQFNNISTKKTVSIPKPEDDGLLMFRFIPAVGGGKPDAAYAVFEPHPETRTAKKPTDGPATNGTNGHGNGHSKPSLSEVARENGHSVTIGDSDSAFSSSSDSESDDDSKKAKYAAQASFEFTLPKWQALPTLHHVVKNLAGVPIYEVLEAKVEEVNGETDEFTLARRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N554</accession>
    <name>A0AAE0N554_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N554"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12602" checksum="DA202712B96B1EEA" modified="2024-05-29" version="1">MATTQGETQTPITQELKAAAAEGRPITVAEVSTIASAESEMTGRGPAKGGAGAVAQSIHDRQENFKAKADEVLQKPAGEVTKEDAADLMRKEARAIGDNPGKDSVSAKIQSIADKNVNANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6S1</accession>
    <name>A0AAE0N6S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fasciclin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_290371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6S1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042157592" evidence="2">
        <location>
            <begin position="31"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="43396" checksum="8552FD94FAD187AC" modified="2024-05-29" version="1">MMFGAFGSAAFGLPSSLVALLAVLPTSSLAWSIRATAPAKNLGTVLAENTNLTTYLSLVKAYPDILLQLPSDDGVTLVAPNNAAFSKYQNWDPNNKELVTSLLQYHILQGVVLTASVPKGASNFATTLLKDPKWTNVTTGQQIVFDKQPDDLVVFTSGLGTRSTVVESDIPFTGGLVQVVETIMVPPARLEPTARDAYKDLQSFLGALYLTGLVREFAESPNVTIFAPRDIAFQRVAGALTALSKEELTTIMRYHIVSGQVLPSKSFSNTSSLATSSGKLKITRSGNNLYFDRAQLLQPDILLANGALHIIDGVLNPNNTAAAPDPALGTQTPAYPQTGATATGTAVAHPFTSALPCTVDCPVPTATDGSGGGGGGSGAAATSGTGAGSKASKGGAAAGPRCTGMAAAVMVGVAGMGLVGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N798</accession>
    <name>A0AAE0N798_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_421407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N798"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3372718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="34939" checksum="FC74B2AFA63995AF" modified="2024-05-29" version="1">MRPPQFRFPSFASAAPAGNNSQQQTANNNGNKNTGNMLPMLTLPQTTRNNIVAALGEFIGTFLFLFFSFVGTQVANTPPPVVFDDGNTVAPPNASTLLFIALAFGASLTANVWAFYRVTGGLFNPVVTLSLVLVGGLPAVRALLVVPAQLLAGIAAAGVVSALLPGPMAVETTLGGGASTVQGLFIEMFLTVELVFVIIMVAAEKHKSTFLAPVAIGIAFFLAELTGVYYTGGSLNPARSLGPAVVNRSFPPYFWIYWVGPILGSLLASGFYTLLRYLRWKEVNPGQDWNDVEKMESEKQAIHSDHGSAVESTEGGLLDERQAVGRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8K7</accession>
    <name>A0AAE0N8K7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_257196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8K7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17830" checksum="8F4201DB91DF0912" modified="2024-05-29" version="1">MATSTPTSSMIENTIKEYFASKLEFFDTKSSAQSSRTQTEDCNFSLAPASFHRELGIPAGFALSNTAWDEHVLGQLPLLHTAQSERLETVIDAAARKAVVHVRNEMVLKDGNKATVENALFFYFIDDGTKIKKIVEFTDVVETKRYLGLVEEAKHAAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9B3</accession>
    <name>A0AAE0N9B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_526174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="856"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1418"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1500"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1516"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1550"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3374878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1574" mass="166406" checksum="79D123549513F14A" modified="2024-05-29" version="1">MTSTASQQPNPASTPSAPAATSYASAAGAKKVTPLIATGSHPPPVVGSSGSAPQNGKPTTASPVNGRPNIPPAVPAVARGSSSLNGGAAEHSRKSSVTISANAPSSHITNGGPVGGANKTIPQFGFNESPAVAHSTLAEPIAIPGNPRITSPAQSPLPIPQQSGGQRAPSNSQATPLTFGSFTGENDRHMKQPSVSHNPAAMGQSPHTRRDSQASAHGEATGHRGGYANRGRGGNFNNQYNNQPMGYPPNSGRPFNGGGGRGGYSQRGGGMPQQPYPNSPQPMRAVPSPNIAPAIPHGTPTMTAAALAGGQQYYSPNPNMNIYNQPQAHVKSPFISSEHPSGKALKKKNGLRRDAEKSHPRPQTSSLKQMGTEFTQRSRRHSKRWDSGPEAHRDMNGGPPAPDYPDGAPANYGYVPMRSVPMLQPPFAGPIDLSPESGHFESLLTGTQQQMHAGYQVPAMDQYGRPLAYPYPQQMQQMPQFYAQPPQAAPGQFQPSYNAPAYQPQPAATAMSRNPSQVSDRPASSTGQPQAPAIAQGTPQQRTSNAAPVVVSSNAFSRPKKSAITIKDPSGNLIDLSQKKAPASPSPSIQQSRTPPAIASTPTPPPKSNTPAQGHARSDSIVAAQKSAEQVKNEFRDAVLQSAVNDKAKEDEAAKAAADKAAAEKAAADKAAADKAAAEEKAKEEARLKEEERVAAEKKAAQETKAAEEAKAAEEAKKKAEAEAKAKAEAEASAAAAKKAEDEKKASVPAAAPAASGETEDEEFERMVREMEELDARREAEQAAISEKKKAEAAERKKLDDAKKAISAAENDKLLREQEREMERLEEEKERARAGGNTESVADLLAKKIDNLKLSDTKAAPADKPTSPGADAAGPKSATEKRSKPVPLNLAPLKTTQAIEAPQPSAALQSLRSSRFLQGVEYNIYPAGVASPNPALNAAVHKKGKVFKYDAQFLLQFQNVFTEQPSLEFHQQVKSLIGDSDGSRSASARTPGAGSARQARVGGPAVGGFPQPVAGSSAMGNFKGSGTTGSDRFALPTGGNLGRPNVPSFGNRSGTFPGPSNSFTRTPSNNRGEIPGSPRQQSRRGGGGGSKRTDYNHKSDAQAAKVMPLTAGMEVKPIAITATGWKPTSVFNKAAAAPTAVASQSGHLDPEMVQRKVKAALNKMTPEKFDKISDQILAIAGQSKNEQDGRTLRQVIQLTFEKATDEAHWASMYAKFCKRMLETMSPEIRDENILDKAGNVVSGGALFRKYLLNRCQEEFERGWKVDLPEPAVGDDGKPAGEAALLSDDYYIAAAAKRRGLGLVQFIGELYKLGMLTERIMHECVRKLLEFQGVPDEAEIESLTKLLRTIGGNLDSTEKGRPMMEAYFQRIQSITNLPELPSRLKFMLMDVIDLRRQRWNSKDTNKGPKTLEEVRAEAEAAAAQKAAENARSHQRGPPGRGPQGGRGGDARNFSYTQPVPNQVGMDDLRRLKGNVSRSASNNPSFGPTSMFMNSRSNSGRRLGGPGGAFGRGGEDSGASSRTGTPPTRDSVAHTNTFGLLADTGDNPASPPSTAASPAMSKVTLDTAASDTKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9B8</accession>
    <name>A0AAE0N9B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_526317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9B8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3375030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17398" checksum="EC0623713808AD7C" modified="2024-05-29" version="1">MENTLYGLRALPRDEPVPSPEPSPEYEYTTPPFPSLSFPIESPRWTLSTITDIWRFTLFWTLILYGLFHVGAVAIALLMQVGRKRSNWKYLWTVPLLYAFVAGVEALIAGSLVGLIVGASYRAGGFTMSTWIPFVWGWVNVLVLIVSSFRIQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBN7</accession>
    <name>A0AAE0NBN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_435692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="105"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="42381" checksum="036D2255CE1F2BC8" modified="2024-05-29" version="1">MAPHAQEEVAGEAPTSAPIVVPAGKLESVIANAKDGYGTLFNLSIDKDAELGKKGHAAARYPHYLPTWETRTSKDAPLEPIAHHDPGLDADPSYPTLLASPSTQITHLTPTIGSEIRGIQLSSLSTSQKSELAHLVATRKVVAFREQDFADLPIADALQFGSFFGKLHVHPTAGIAEGYPETLIVHRGAGDESVDRYFANRTSTVAWHSDVSYEAQPPAVTFLYALEKPSVGGDTVFVDAVEAYNRLSPAFQERLHGLKAVHSAFEQANGALARGGILRRDPVRNEHPLVRTHPVTGEKGLFINKGFTRDIVGYKKEESDALLGFLYDHLAYGADFHARVRWEPGTVVIWDNRVTQHSALVDWKNGERRHLARITPTGERPVETPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCC8</accession>
    <name>A0AAE0NCC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_495811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCC8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3378178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="20978" checksum="0C0ECCC05D5BC624" modified="2024-05-29" version="1">MPSPPTKQRKIAIVGSRSVGKSSLAVRYVDGHFVESYYPTIENTFSKEIRYKGQDFSTEIVDTAGQDEYSILNSKHFIGIHGYMLVYSVSSLPSFEMIQVIRDKILNHLGTDSIPICIVGNKSDLRPEQRQVTPEEGRALSESLKCAWTEASARYNENVGKAFELLIGQIEKSQNPGGEPTEGGKCTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFZ0</accession>
    <name>A0AAE0NFZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component PIG-T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_434176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042244949" evidence="2">
        <location>
            <begin position="20"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="602" mass="67526" checksum="2D67077BAB7D3EF5" modified="2024-05-29" version="1">MRQLFSLLLLSLLSFVCSASSDYHEQLVLRPLPLSALLASFDFRSNITLSAFETHNFRFFPRSLGQILQYANTRELHLRFSLGRWDAESWGARPWDGAREGGTGVELWAWLEAETDDEADHKWLTLTNALSGLFCASLNFIDGTRTTRPVMSFQPEGDHPNSTENMHLLYGVLPHEVVCTENLTPFLKLLPCKGKVGIATLLDGHKLFDASWQSMAIDVRPICPDDGECVLQIELTIDMVLDIERSKRPRDNPIPRPLPSHELMCDTSKPYHADDTCFPADYSANQDWTLSQVFGRNMKGICPLTDPAVPPVCLQVPHSRRVFVSSGVVEKKNADGTSRCFEISPKADFEMIFPRPEKTDGEEGNAAQAEIALADVVKPETPLLYAERSFTGHGQERGGVQTILRNPSPDTEVEFIYMESLPWFMRIYTHTIEAHVGGESKSNGSLIEEIYYRPALDRARGTQLEMRMRIPPAATVFLTYDFEKSILRYTEYPPDANRGFDVAAAVITILNRGEERKAAYTLRTTSLLCSLPTPDFSMPYNVIIFTSTAIALAFGGMFNILVRRFVAADEGPEAGLGKKLSAKLSKVLERFRKKKTAVEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG54</accession>
    <name>A0AAE0NG54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_494896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="284" mass="31137" checksum="3152B9E558AD1E41" modified="2024-05-29" version="1">MGSTFQPNGSNASAQGMQAYAALSLYQPHRARQAIRDAHEKKIPPLLGYNATLSSVPMTQFLAPMGYDAVWIDWEHSSCNMVHDTMFMSQGKTVPWVRVPGHDHAAIGYALDAGVSIVIPQVETVEQARHVVSSAKFGLRQNGTRSAPPFRLTQGLTDMPLSPARGDVWQNMNDQAAVMIQIETLQGIENLDKILREVPDIDCVWLGSLDCRISMGLPGKRRDGRDTLKKHDVPKAGFCFGSADAFTKTAGEMALMFISADVLQLVQMNKKLVETRELLGAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHJ5</accession>
    <name>A0AAE0NHJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_561304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHJ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="415" mass="46904" checksum="C5B1D7B2EAC8EEBC" modified="2024-05-29" version="1">MAPRGRPRKNPASAAAAKKESPPSVTPEAPEKSRRRSTRVSSSGKTSNYFLEEEQSESSAFVPDDEDETTNKKKRKPKAVAAVAKSDKKTKRAKTTPKGGKVVHDDDDDDDDDYDTEAGATVNAGQEDSDDEIDEDAPPKVTFTPLIKLRDTGCIAYADDRIHKNTLLFLKDLKANNKRPWLKSRDAEYRRSLEDWETYVMSLTEKITAVDETIPELPFKDVNFRIYRDVRFSNDQTPYKPHYSAAFSRTGRKGPYACYYVHMEPGKSFIGGGLWHPDGPAVAKVRASIDERPKRWRRVLIDPEFRRVFLPSVAGPGVKEDEVIEAFAASNAENALKRPPKGFIPEHRDVSLLKLRNYTVWKQLDDAIWSRPGGQEEVLKCIKAMVGYVTHLNRIVMPDPNDDDDDSEDEEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNN0</accession>
    <name>A0AAE0NNN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_395222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="60"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="628" mass="69686" checksum="FE5A5CC9FE17EA96" modified="2024-05-29" version="1">MGSTAFAAYAAQNSAANGTADGLKTVTALGRWSILNKQLPAVDKIKAIHVYDFDNTLFKTPLPNPKIWNGPTIGNLSNPDFFVNGGWWHDSRILAATGEGLAKEEPRAWNGWWNDKIVELIGLSMQQKDALCVLLTGRSESGFSDLIKRMVASKGLEFDLISLKPAVGPSNQRFSSTMNFKQVFLEALMETYKHAEEIRIYEDRPKHVKGFRDFLTDYNKQQSGIGGYKTRGPIVAEVVPVADLATTLDPVVEVAEIQQMINDHNAALSQRRRGARDDRLTIKKTVFYTGYMIDNTDTQRLLALAKIPQHLPEAELKYHGNNIMICPRPCPASIQEKVGGMGTKMTWQVTGTASFENSIWAACLKPVPATAKFHTDNPSPIVVLALRKGARPVDAGKIKNWQELPQDKTFIFETTVQEKVLLRIEAEDPTEGEYESLFPNKPSKRKHAGGEDDFRSRSGNQQQNQHTGGYRNERGHFHQPGLSGRGGNNQRFRGGANSAPNRGFKNQRGGGQRGRGGQGRGHHYKSLDDVAARDSQGGFAQQVSYEDDPQRNIQASQQPQSQGNQGYNSQPQYQPPYQQQQSHQQQYQPHLQQYGGGGSWPQQQQQQQGRPVGGPGYGAGGPELNNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNU8</accession>
    <name>A0AAE0NNU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_543130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285336" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="756"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3384977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="843" mass="89485" checksum="014EE0D1A5A3C2BE" modified="2024-05-29" version="1">MITLLVLAGLAAVVSAADTPSIGNAGFPSPWASGGTGWDDAYAKAKAFVRGLTLVEKVNLTTGTGWEADRCIGMTGSIPRLGFRAFCLQDGPLGIRYTDHNSAFPAGINVAATFSRGLMRRRGEAMGEEFRGKGIDIQLGPVAGPLGRVPEGGRNWEGFGPDPYLTGIAMAETIEGIQSRGVIACAKHYILNEQEHYRGRIDVRIDDKTMHELYLWPFADAVRAGVGSVMCSYNKINGTYACENEWTTNYLLKNELSFQGFVMSDWGAQHSTLGSALGGLDMAMPGDGGAAPYGALWGGALTEAVLKGDVPQWRVDDMAIRIMAAYFKVNTGNFSSRPEVTFSAWTKKSIGPLHPSSNKTFTVVNEFVDVQSNHGALIREIGAKSVVLLKNENRALPLKMPQSIAVIGEDAQDTPGGPNACAERGCIKGTVAMGYGSGTAEFPYLVSPATALKLQATSDNTVFINTTSNWDLDAAKAAAKGASVAIVFATANAGENFIVLDGNAGDRNNMSLWDNGDELIRAVASVNPNTVVVLHTAGPVIIDYAVQHPNITAILWAGFPGQESGNGLIDVLYGNTNPQGRTPFTWGKSEKDYGAELLFNSSNPVAPSQTFDEGIFIDYRAFDKASIEPTYPFGFGLSYTTFDYLDLHIQVQNVSASYKAMSGATAPAPLYGVVNKTAAANTAPEGFEKIIPYVYPWLIANSSTGGSGGFGPAAINGSAQPLLPAGGAPGGNSGLFDVVYTVSATIKNTGGVAGTEIPQLYVQLGGDENPFSVLRGFDEIVLKPGEAKTVTFGLTRRDVSNWNSTSQNWEISTKEKFVFIGSSVAAVRLHATLPPPQGMSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP42</accession>
    <name>A0AAE0NP42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">B0H63DRAFT_559632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3384915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="42625" checksum="E25D8CCD15103774" modified="2024-05-29" version="1">MATLQAIKYSRGKLLVLDQLRLPHEHHYDEVTTSEEAFDYIRSMRVRGAPAIAIVAALAHAVELHNGSCTATSPEDTLAHIDGRLDYLKESRPTAVDLSNAVTLLKLAVRAAQIEGLAHPEAKEAIMSAYIEAAENILAKDLLNNQSIGSFGAAWLQQQYNASPDRKISVLTHCNTGSLATSGHGTALGIIRTLYAEGLLEHAYCTETRPYNQGSRLTSFELVFEGIPATLITDSMAGALFSLRRESMHIGAVIVGADRVVRNGDTANKIGTYQLAVLARYHGVKFVVAAPTTSIDLETETGAGIKIEERKAEELTQISGVLVNPDGSIDATRTARVAIADQNINVWNPAFDVTPHSLIDAIVTEKGTVVKGADGKFDFSKVMPERWAAIVGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP74</accession>
    <name>A0AAE0NP74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_522531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.90">
        <property type="entry name" value="Immunodeficiency lentiviruses, gag gene matrix protein p17"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012344">
        <property type="entry name" value="Matrix_HIV/RSV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1720" mass="190073" checksum="7F29293F1B7D3FCA" modified="2024-05-29" version="1">MLEHMLKLAEPKIPILITARAIVSNRLQPAASHPRTSEPGPSNSPWRLATITAEMELFSIEAETASLLEDMSNDELCSFAELHDDPAIDGQIELYIYTCFLLFKKSVSMEHLERAVQRAEGWVAVTPTDHPDRIRRSRIFDMMSAWIHQHRSILEGITFTLPGVNQRMAQEPAVDEIGVEIRYLSNQATRLAESYEQTGHVEDLKEAVRIMEQALELGGAYIEPGILSNLGVMLGMQFDRTGSMDDLNRAVDIATMAVDATPQDHPDRAGYLNNLGNWLGRRFNRTGSMDDLNRTVDIATMAVDAIPQDHPNRAAILNSFGNWLGMRFDRTGSMDDLNRTVDVATMAVDATPQDHPDRAGYLNNLGNWLGTRFDRTSSMDDLNRAVDITIMAVDATPQDHPDRAGYLNNLGNWLSTRFDRASSMDDLNRAVDITTMAVDATPQDHPDRAAILNNLGNRLGTRFQRTSSIDDLNRAVDVATMAVDTTPQDHPDRAATLSNLRAMLGMRFDRTGSMDDLNRAVDVATMAVDATPQDHPDQAVTLSNLRAMLSMRFDRTGSMDDLNRAVDVATIAVNATPQDHPDRAGRLNNLGHRLGRRFDRTGSMDDLNRAVDAATMAVDATPQDHPDRAGRLNNLGNWLGRRFDRTGSMDDLNRAVDVTTMAVDAIPQDHPNQAAVLNSLGNWLGMRFDRTGSMDDLNRAVDVTTMAVDATPQDHPDRAGYLTNLGNWLSTRFDRTGSMDDLNRAVNVASTAVNTTPQDHPNRAAILNNLGNCLGTQFNRTGSMDDLNRAVDIATMAVDATPQDHPDRASRLNNLGHRLGTRFRWTGSMDDLNRAVDVTTMAVDATPQDHPDRAATLSNLGAMLGIRFDRTGLMDDLNRAVDVTTMAVDATPQDHPDRAGRLNNLGNWLGRRFDRTGSMDDLNRAVDVATMAVDATPQDHPNRAIYLTNLGHRLGTRFDRTGSMDDLSLAVNVTSMAVDTTPQDHPNQAAILNNLGNKLGTRFDRTGSMDDLNRAVDVATMAVDATPQDHPNRAGYLNNLGNKLGRRFDRTGSMDDLNRAVDVATMAVDTTPQDRPDRAATLSNLGNWLGRRFDRTGLMNDLNRAVDVATMAVDATPQDHPDRAGYLTNLGNWLSTRFDRTGSMDDLNRRLSSYKEGWSCHTAPPSIRIRLARAAADILASQRKWDESSQLLEEAVKLVPAVSPRSLNHTDKQHMLADSAGLASMAAAVALNAGTPASHALQLLELGRGVIASLLMDMRGDISDLKRKHPGLADEFISLRDELDSPANRATPTISNDSTSLWESQAKRRRQADQKFSELITRIRDQPGFDRFLLPPAEDEIMAAADPDPIIVVNLSSYRCDAFLVEHNRITVLKLPGLTMGEVQERAQDLQSSRATGSFHITPLLEWLWDSIASPILNAIGFEGSVSDDKWPRVWWIPAGLLSQLPLHAAGRHVQGSTEAVLDRVMSSYAPSIKALIHGRRHPARESAGPFSDYALLAAMRKTPDLAANQILPFAGDEIEMLKNVCRSLKLWSLTPTMRKDNVLQHLRTCKIFHFAGHGQSDPVEPSRSCLLLEDWKTNPLTVGDLRDHRLQDNGPFLGYLSACSTGSNKAVKLADEGIHLVSAFQLAGFRHVVGTLWEVSDKHCVDVARVLYETLRDEGMTDVAVCRGLHRAVRALRYGGIKGEKEKDEKARDATLEFARPRVQKMADPYWVPYIHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPC7</accession>
    <name>A0AAE0NPC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional purine Ade1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_494330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPC7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="77"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="36411" checksum="03107E9831DE244A" modified="2024-05-29" version="1">MEDASLNVLLVGKGGREHSLAWKLTQSPLVKHVYVVPGNGGADGLPNVTNIRRLSGIPCFAPTKEAAEIEGSKTFAKDFMKKYSIPTADYQAFERYEDAKRYLEHVDGSRVVIKVDGLAAGKSVILPADQAEAHHAIHEIMVEKSVFTFRDGETFYSLPPGQDHKRILDGNKGLNTGGMGVYAPLSVVTGDHLNQIDNDIIRPTLAGMKAEGTMTLRAGPDLHWDAFTGVMVTPTGLKVLEYNARFGDPETQTMMMLLAPECDLAAILLACTLGKLSKLPSIQILPGYACNIILSGNTIELNPCPEAQTDGGRVLSVAAYGESLEEAVTLAYVGLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPS9</accession>
    <name>A0AAE0NPS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_182370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="231" mass="24414" checksum="95BF631D633A80C2" modified="2024-05-29" version="1">MPPKKPAKPAGAPSPIGEYSVEFEEDEEEDDESAYEQVAASSKRKAATTTTTGRPRGRPPKVAKVAPTASGRPRSRPRKTPAVEEEEAVKAVPSSTGRLRGRPPKSAPVAVASEPPRSRGRPPKNPKPAPAAATKPSKAAPVPKTYFVRMKCRDTGTGEIHSTAEKGTIKFKKGSGKASFASFVGEVDMPGIGSRVGFTAHKVSDAPGVGGDSWDEYSAQASEQARVGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPZ4</accession>
    <name>A0AAE0NPZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_560135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPZ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="523" mass="59028" checksum="C9888993BF6EFF3C" modified="2024-05-29" version="1">MRLLNVKTLALKDFGSLPPRYVILSHTWGAEVSFQDIQQIAHATISATKPDAFAKIQRCAEQPIIDGFEWIWVDTCCIDKTSSAELSEAINSMFAWYHDSYELLADFYTGSNTKYQWLARGRIQASRWFTRGWTLQEPIAPRTVEFFSSNWMSLGTRHSLANFLSGVTKVPKAVFKGEKMSRQYCAFDKMSWAASRTTTRVEDMAYCLLGLFGIHMPLLYGEGTRAFTRLQEEIIARSEDLSLLSWGISDFWLNGVYDKIPLLACQSKAFAEPMLTDITFDSTLHIGTAGHLSNPSRELSLQQTFPQPTVGRRGILATLFVGLSPSQTSGNPLDALSCLFAWNFVTATIDGLRLLVGFNSQVDWPPELLSSGTDPANPDNSHDGLEKELKKTTAPVEAWRHQGARLLCLDAREQHRLTPRLLYLMGTDEHLENNLIHIKLRKDHLVHMRWHDMESEVSLRNLCSSSLHRLSLEPSRTLPEPTRQEATSFQSRRQTNGQQGRVSTWEAPPSLTLRSKSTSDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR21</accession>
    <name>A0AAE0NR21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyltransferase Family 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_395632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="607"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="96100" checksum="795278D3E4013F9B" modified="2024-05-29" version="1">MQQLHQDLRHHRKPLDEPPVSSPSGELPSLDQRQHHRHLTSNNTDNPSVRHPRPDDHAHADPTSIHIAPTATSPVQVEAPAPQAPTPAPATAPSLLAATHYELNQSPVSSNAATPSRSQSSTPVKHRRLKPFIQAIMAFEKGRKFSTGTSVHRKRQMSTLVEKEGHFGPALTTLYLGISAVFSDDHTAVVALAIHDTIYLIDFSIKHIVLDDALRMGADVIADYVISEVERYEHENFAKFIGAGLPTTLKYMSPTLCSRLWLELDIVPIVMRPDDEYKEKSFWDVKRVDEQADSMARKCIMNFGPSLVPLLQVGFRGIVQTDAGFRAHLTTVQNHKDTCTPATWDSMLTYAKKLRHTKTKIAFFSSTPQGGGVALMRHALVRFARLLGVDLTWYVPKPRPGVFRITKNIHNILQGVSHPDQRISAEEKQAIIDWITENANRYWFSEGGPLCTPEAGGADVVIVSNFFGCLPEFPSPVVPSFMQERQACSVSWHMTSAYRNPHPQYLPIHGTDDIRSDLVAKAGSPQADIWDFLWSNIQGCDMFISHPIPIFVPHTVPREKVVYFPATTDWLDGLNKHLNKWDSGYYGHIYNVACHSQRMTELNWPARKYIIQVARFDPAKGIPTVIDSYAEFRRQCEKANFTDVPQLVVCGNGSVDDPDASLIYDQTMSQLETYYPDLIKDVSIMRLDPNDQLINTLLANAHVVLQLSTREGFEVKVSEALHAGRPVIVTNTGGIPLQVKDKVNGFLVTPGDWKAVAGHLMDLFTNEELHAKMSYEARTGVSDEVGTVGNALGWFYLAAQWHEVGVEKNGKGGIKGNEKWVNDMAREEAGFPYKEGENRLPRHFTQSKELPVNTKPVSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRR3</accession>
    <name>A0AAE0NRR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRR3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="33993" checksum="3F25FCC522EF9A3D" modified="2024-05-29" version="1">MGTTASTDVSFSTVTAAREFRLDDDAATLLAMVRVTPPAGVADPPEGIWVTAWFPLDQVLGNIHGTFVYGFKNWSKSRSAAEINGTVLTANLQTESGEWLSSSIDLGGKIVGTGSGHLIAQNVPVVVPVTQESQATVLQQLATKLASSPSLKLAALNNGDGTTTFVATETDPTKVFTGYTNQSDDSKQAKIGYFRAGLDIGGAESDTVFKTFDASATAAVFHVADTSGRAITQFSADVLEADAGVSAAGIAAGDTGVPTYFSAGAQVNLVKLKASAFSMNAGLGVKTDIGLTDYSLNGHLLGTGITFGKKMAISVFGFEFGFDFGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSG4</accession>
    <name>A0AAE0NSG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSG4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="35125" checksum="0F39EF9BE9DCA9C2" modified="2024-05-29" version="1">MQLTASALLLIRTEKRDSTSGGRFVPRLIELSNHIEDTPLHILEEILPAGPGSGRGKLFMNVITVAAMATVLTKLGALTVPFHIYLWAWLMVSGWLAVQTLLFLDLSHKLVTLDERQPLINNLCAAARDLSNVNLYILTLAAFAPVFCYLGYNFNTWLAALLSPLHASGFYKYVLLPLSVLVVEMLWIFGPTILLGVLLLPCSSLFDSVFVWVLAGSVLSFPIGVMMLLFDRVNMWVRERYEGIVWSALSTCVSVCVWAVWAYIWMLASLHNRGREMAGGFVIINVFIAAIVFAVVLFIYDPIGTSRPNWTEWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSZ0</accession>
    <name>A0AAE0NSZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_150039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="247"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="640" mass="69944" checksum="CDEAE412FADB24AD" modified="2024-05-29" version="1">MIDTCPPTMPSIKSANGDSHFPQRLRNFFRINSGGRDKDANNHGLGSASTGALKAENKTPFRQSRFFSVGRLRSATVASEGNALDESMSPTAHANPYFAHQGQPGLRHHNEGSVPPSPPDTPILKIDGPNGTANQPTASTKEELARKLRRVASAPNVQGLFSKSKGSGDRPATAELSKEPLVQDNDSNTVGFAESPKSTGYLTSGLAVPDADSLGALPLPRSPLAFRRTYSSNSIKVRNVEVGPQSFDKIKLIGKGDVGKVYLVREKKSSRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSDPGGKPTMIIGKNGTSTSSLPTIDTKSCIANFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILVYEMLYGTTPFKGKNRNATFANILREDIPFPDHAGAPQISNLCKSLIRKLLIKDEARRLGARAGASDIKGHPFFRTTQWALIRHMKPPIVPNQGRGIDTINFRNVKESESVDISGSRPMGLKGVPFESGIATPGLATPGLDVVDPFEEFNSVTLHHDGEEQYAADASAHAKANGYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT06</accession>
    <name>A0AAE0NT06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II assembly factor RTP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_468819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT06"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="558"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="831"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="100297" checksum="9B9ED9DC13807F54" modified="2024-05-29" version="1">MERKANDKQKAAEKISRPKLIQSFIDIGGRAFSPDATSDSRQAAQREFDDLLERTRTLALIGALSILIRPGSAPPWLRAKLKETLAEIPLRPDGVRSTLEFVFSVHPSSTVRASEAAIPQKRGANITQEALQMASQLIASPAASIAEELWYSAISPQLLVLLDGDDGPELVKTVSYIIGFGILGRKASGAPGTLGWRYLAEPMLSRIRPLPNAPNDGPEVITDEIIDLSKEKVIITFQDLATALHRLFSIVVSHPNPGLCKRLLAPLPLQLWALSSWQSPSLTLKEKICTPASELLKTFLKLVSSPGLLLLLVRNVGYIGGEDPQNPDWVYKETSEGQVQIVATNGITRSGDASHHPTLQEIDQKIPKLLDLITASFSDANISTTFLDLLGRWLKSAGKRRGENVLLKQETDEGDDPMTQLAELRVLQSMMDRFADKLANQPKHILELVGQLLVSPADAPDDDEEVNGVALSLVNMIITVPGFMKSRVDPDVLRIIESSLDKLSRREDADIARTANSLSLLLKHRDEVDAPSGNVSAPTARQIEDRKTYSLARSYLSQSDALPPIKMEGLNLIANLIVSQSPILDIPGILVLMSSLMSDNEDYINLQVIKIFTLLASRHPKSVTTELLDHFVDPKETESVDSRLRFGEALSQVIEWLGETFSGETAQQVGDALLSVAGRRGHRPKTEAKQAREERARQLKNKEALDVWDGDIPDLSDDTTTVSEEAQARNEILSRIVSGWESKRGAEDVRIRTSALSILGNAIETNIAGLGPILVSTAVDLCVNVLQLERDMEHGILRRAAVLLVLSFVRALDAAKQAGKRLGFGLAAQAQDDIVRTLGYIAETDNDGLVQQHARDVIESLQNWQVAGLVPSPGERLGQQQQSSSGLTKLAGLNIDAERSVSLLPGGSTPRPRIEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT40</accession>
    <name>A0AAE0NT40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_493611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="51"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="716"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="953"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1517"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1569"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1591"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1604"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1741" mass="193792" checksum="917FF8C1857D53B1" modified="2024-05-29" version="1">MASSPPASPGTLPQRPLSAMVRPAPRSASRMSMTSKAGGGSRASDEDTKTSVRVVVRVRPPLNAADPGFDLIPQRFQRSVVQVQSETNLSIDSPQGRKLFVFDRVFGPEVDQAGIWDYLEDCVNVFTQGYNVSLLAYGQSGAGKSYTMGTSGPAEQENPELMGVVPRAAQALFDKLEGPKTNPNRGSMSQLRAPSRYSTQSTPQKEKNWSLRATYVEIYNEQLRDLLIPEHVPATERGSVTIREDVKGNIILTGLRTVEINSVEDLMNALNQGSTLRQTDATAINARSSRSHAVFSLNLVQRKSKLQTAQGAEKRFSVPLDMTGGETWVTTDSKLHFVDLAGSERLKNTGAQGERAKEGIAINAGLASLGKVISQLSSRSAGSHVSYRDSKLTRLLQDSLGGNAITYMIACVTSAEFHLSETVNTVQYAQRARAIQSKPRIQQVEEGDKQAIIDRLKAEVSFLREQIRSAERGGGERRTLAAGGERSERQNGREVELQNQLLDAQENYTSLGQRHAKLIAEMAKARDNELAENQNHEDSLDDSATERLNRSNSFAQAVEQVVLEYEKTIQSLEQSLASTRATLSSTETSLLEKETKCAYSETIANQLQARLQKLMDREASTENYLHDLESKLDGHTSGEEKNATIIMELRKEISRVRENEAACEDYISTLEERLAEADQDAELMQREIDRLEQVIERQRSLGKLDSLLYELDHIQQDTPTPEPELAMSNGAGHRRTASRNLADHSRSQSHASRMSHMEEVIPESGEEDILEEDDPEALTYDQKLAREATPKGSQANLLEATDAADYPASPAQTKFVADKLESVTQELFDLRVEHEVTVNEFGNLHSKYEEALRALAELQDTVDEARHPGRQRDSLLSVASPIQTRPQSFLSDARSSETRDGTQFSSSRSLSSELSSAMESPATVLDSSDAETAVPRSGSHSSSPVEQNGSHALTSELNRLKSLAAEKTAAEKELAERYAQLEEKHHETLDMVEELKTEVAKAQAANTEASSPRGSTPVIRRKSSQNVMIIDRAHRSFASLRNIAAENFENQPDVMQNFELNLNAAMHELHARSERIQELEADVASTKKEMEMKMAIISGLTRERSSLKASPMDMAVVSNLREQLEKSEKQMKALQETHAVRERELQVQVPTQTKISANGTSEESLEKLEAQTQRVSELKAELASWQDKHKAALQSMQAVEEDMKKTIGDLEAQVASFSAQIAEVEQKEPKDDQEAREAEIKQQKLVDFLRTEIDEYKAIINKNLTQVAEVEEQHTATKALLQIAARDRDLASTEVENHKQLIAKLDEQMAEHERTVKAHQDSLYELQEKHARDIDDIRTASVQEHQSQLAALKSEHANQLRLLEGDLTEAHEDLMKVATQVAFALGLDVSVEKITERIEDLIADHKALAQEQDKRKELEQHVVELTSINDTVVRDLENVRATLTEVLAAEGERAKNPHPVPEQAALVKKKVVELQTSVRKHSRLVEELEDQLATNFDQTQLTNNRLSTLQSERHTQLEEANAARARLQSELATIKEEYASLQVLWEESRFGNLSANASQAKYDGMTAADSPQRSNSINSHLRKSASVASLPSPPPAIPLPPLPSSSSGPNGVPGSPTGRPASKDINASQIQEDQEARIRLIDKHLKAEKQLTATLEEALTDLERQQNKIKADCDAWRRRATELEGELKELKDKPQQDNRWSLQQVEEERRKRRDAEIARAHLEERMNTISKKKKKGSLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTM6</accession>
    <name>A0AAE0NTM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_558990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTM6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF425">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="229"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="844"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="927" mass="103612" checksum="52A68FF22B681108" modified="2024-05-29" version="1">MAAPPPPVDAIAKKKDTTKTPQELVSEFWDKFFAKKPGRVTSIFPRSLYATLLPPSQPRGASSARNAAESYEAAAKECREKVKRIIRECNRTNEKFTDPDFDIESDNNNNCLNGLVREDWSGLFSDSGDSTSVSAGQLKSSLDTLVDSNVLGPGGSVPLDPGVVRGYINDSNPFAFLFGEATRAAKTGGNVHGSLEAVQKALKSANGENGNSAKPKPRSSDRFKVSCGEWYDPGSIHRLDWIFDSPQFTVDGYAASDIKQGGNGDCWWLASVATIAHRKDLMDKVCVIRDEEIGVYGFVFYRDGEWISTVIDDNLYLTAADFDYYGDTYDSTGKRAREHKQRYQTGSEALYFAKCEDKNETWLPLLEKAYAKVHNDYEAISGGYPGEAVEDMTGGVTTTVASNRVLKKDKLWRELVNSDGEFVFALSALGTGWDWKKGGLALGHAYSILGATEEVGEEGEKVRLVRIRNPWGERASNGIGEWNGPWSDGSKEWTPYWLKKLNHKFGDDGIFWMSYKDVLDTFMFLHRTRLFDEKWTVVQQWASVNVGWVAGYLNTKFIVEVKKAGTVVIVLAQLDDRYFHGFEGQYQYSLHFLLQEVGTNEHICRVRPVHAWENRSVSCEVDLEPGIYEVLPKITATRWKGEKMVEDVVKEYAEKNPAKLRQVGMQYDLAHTKGGIPDEDELLTKKKAEEKKKADEKKKKEKEKAKRKKEKEKAKKARAKAKAKREKLKIVTNNNTTTTITTTITTEDNKPAEDKKDVKKAEGAVEDKSKSDEVTKPAEDTKEGEKKADDKPSTDSTAENTPTSSITSGDEPDPAEEVKKDSETKPEEKKEEQTKGEEAKVDEVVVDDESDDEESEEEEEEEEEEKKEDEPPVVDDDEDRTPWNAVCVIGLRVYARDPEVTVTLAEPKSAEEAASLVMDSKAVGATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTT1</accession>
    <name>A0AAE0NTT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_431458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTT1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="204"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="346"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="628"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3387541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="839" mass="90897" checksum="9C8CC6923D18F6DF" modified="2024-05-29" version="1">MDLRNNLFGKGPRAGGAPPPRQSPRPVPAGGDGGGYAPAPGNYDPYGARSPGRQASAGYGDGGGYANAPPPPTYNQKPQSRGRSVPLRLAKVEDKTLQNMYIFGNISAVSPRDFPPNKDGSDIYIRLTGPQLRGDYVVTARPTPGFPDGCISLSDPQRTWCGVGMMDELVGELYDVFSQGGAAYIGAMDLEVGFASQKKFVDSPYDQDELAAVFVKTFPNQVFAPGQRLLLDVKNIPLAILVRTVTLIDLTMSQKPGSEAPTRSDPTARGILTSQASIGFFKDAKSPLKLKASNKRPAANAIISPDFKFEDMGIGGLDAEFSTIFRRAFASRIFPPGLIEKLGIMHVKGMLLYGPPGTGKTLIARQIGKMLNAREPKIINGPEVLNKYVGQSEENIRKLFADAEKEYKEKGDESGLHIIIFDELDAVCKQRGSGAGGGTGVGDSVVNQLLSKLDGVDQLNNILLIGMTNRKDMIDDALLRPGRLEVQIEISLPDETGRGQILKIHTSKMKENKVMGEDVNLVELAALTKNFSGAELSGLVKSATSFAFARNIKVGTMAGVSEEVVNMKVDRNDFLNALNEVKPAFGADDEELQDAFPYGIIHFSNSIKAILNDGMLAVESVRVQEKIRHTSVLLHGPSASGKTALAAHIAMKSDFPFIKLITPASMVGFRDELAKKDYLHKIFTDAYKSPLSMLIIDNLERMIEWNPVGPRLSNPMIQTLITLLQTPPPKGHRLLILATTSQRSVMEQLDITTAFDRQIPVPAVQDLRELGAILEKTGAFPTPADVNEALNAVRSYSNSDTVGVGIKTILTTAETSKLSAEPSEWFAEQIAQQITRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU41</accession>
    <name>A0AAE0NU41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_500855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU41"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="19"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="680" mass="76089" checksum="E7AF8EEEF699275F" modified="2024-05-29" version="1">MSPHVVPCAHKGSNHVNPKRLVICCDGTWNNANDSTSALTNVSRLSGAVAHKCCSGMSQVVYYHPSAGTETSKVASVLGGMLGTGVAQDIVESYRFICDNYNPGDEIVIIGFSRGAFTARSVAGMVCALGFLNRAGLDQLPHIFKDYQNWHKWHKTTYDPKETHLMGFTLPNLKRLRRIETKDGSKPVPEFEEDLIKEKKEFYKVMAGLVVTDEKTEEKVANLREMARLYREKLQKHGLSLTEKKQVNGAKVRVPVEGRVKAVGVWDTVGSLGIPNPPFLNSTRAEEEIKFESLDVHPNIDYAFHAIALDEWRTAFNCTMWGAKNNDHTQLRQVWFPGTHCNVGGGWPDQQIATIALAWMADQLTSIGVEFDKKEMARIFFTTSPGVKVREWGMGRIHNPEGLTSYPDWIHSSITAPWHALRGKSTDYATRSPGAYKADGKSGELLVNPHELVHPCVRIRYLYDGLTMDDAGPWQCRALTEGPGRYELQSVPEPATTVRKPRETSVLQEYHSVHGPVKSFFDTPPTGSETDTPAPLVKAEQPHEEELHQLTTPKNHWVWVRKSDGHKLPEEHMGMWERRFIKVNNKLLRWQREKEAAAEKAAREASAKAAAESWNFTKLFSGSKPEPVAVAPVAAADDLRASKRAKSFGAAPHYGFHDIVSWQRGDTVEKEKKAEKKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU95</accession>
    <name>A0AAE0NU95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_509516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU95"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="410" mass="45447" checksum="45294467377FD21F" modified="2024-05-29" version="1">MSDHAHDRHGLMSVSPYAAAEVEVVSLNPARPVVPVPLINDIVRTRYVIPGSVFLVESIEPRLQVARRYRAVRVLLGDGELCIQALLRSEIHGFVDGGQIYEGCYVRVDEVEFQSEDLSGPVLDKPDDGLGDPATAERRKKDKPRKLVYLVVGDMITVGWNNAYLKILGLNGPPANSRPASAVRQGVTMGLGKFAAQKLEVGSKLLPVQDSEDIEDFSDSDDDAFETLAVSEEKAFQRRIQPPGDSRQHAAIPTTKFQGNKPWMANDPTKPLKLTNLRSIPNLPYKQNWMVNVLAVVASLSDVEPSHLPPTHSQRTARLADPSTSKQVHLTVFLDPEQFVPEVGSVVLLVGVKNHRFDGGSLKKYASDRLNNGANWWHGNPEALGWCEAEVSRLRLWWSQQTAQQQQPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXV6</accession>
    <name>A0AAE0NXV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_102332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="173"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="43947" checksum="2828803EC6B4C0B2" modified="2024-05-29" version="1">MGSTSPSPPGLPDASSPTLILMHPTPAERQRTWSLTHPKWGGALEHDDYLAREQHLTETPLTKDGGITHWILTDSSLPPDQRPILSSCESLRKRAVASSPSDATKLQDGIAHGICSVFTDPQFRGRGYASRMMRDLGGRLKEWQGESLFSVLYSDIGKAFYARHGWAPFESAHLAFPPSRDAKTSGGGDSSLRLLKSPDEVVELCAADEKLLRRTIIQRTTSQKGKRRCVALLPDERTLRWHLMREDFMTEHIFGRTTEIRGAVYGSEEGKRLWAVWARGYYGGLQNTEGNALHILRFVVEDESLDESYLVQGAREIIEVAQREAAEWKSEDVQMWNPTDKVRELIDRSELEYEFVDRDSESITSLMWYGEEETADLDWVANEKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY01</accession>
    <name>A0AAE0NY01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_464073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY01"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="354" mass="40498" checksum="3CB142DFC3E91FD6" modified="2024-05-29" version="1">MKNARAFFIRLIGPAAKPGWESGPQTRRKLPRDATFRVFDTSFQTFLPRVLQNMESLTESRLATESNQLSIAPLIIEAFDPEIQGYPIRPFSTSIKSLFLRIPTTITPCFFERFPELEVINLFIHGEIDNDEITAAKKMRHLKILSLYKAGNGWSVNDITKLATSRFDCASKIEHLFMEGWLDLTPIKSFIQPLKAFTSLKKLAITDEQWVPLDSQTNRIESKTSHPLNHSRDEVARAFFHALPTLKELCIGSQITFSASVYARDELAGPSSVRVVRIRNRCMLPPKWTARDPVPANNDDDPDPQDYCLPDSVDEYEDLRFYPEMRWDNCDTSFWDVEWLRAIRLGRGGGGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY55</accession>
    <name>A0AAE0NY55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_104840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY55"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="357" mass="39662" checksum="E9B02D8F8FE2D738" modified="2024-05-29" version="1">MCRPDTETAATATAAASAAAASAEYGAQSDSDQYPDGIEAAGTDEDEEGEFSLDEVDLADDISITSSVYAHTWKNGRRYHKFRHGRYPLPNDEREQTREDMLHAMMMEATDGRLFFAPIVEHPQKILDLGTGTGIWAIEVANEYPGAEVTGLDLSPIQPVWLPPNLSFLVDDIEDTWLAGDNIDFVHLRNMVPILKSPVGLLRNIYDNLKPGGWVELQDVDGEVHCDDGTVPPNWPLSKFCDLLVEAFGAFGTDAHAASAGRRYLEEAGFVNIRHHALKLPYGPWPKDKTLRVIGAYYRICCEEMFPVVGAVHFPMLGWSREETEVLFALCRAAMRDPKVHAYGKMHCWSGQRPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY89</accession>
    <name>A0AAE0NY89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_492671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY89"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="entry name" value="Glycerate kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="entry name" value="Glycerate kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00045">
        <property type="entry name" value="glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="Glycerate kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="404" mass="43861" checksum="3708945094D920CB" modified="2024-05-29" version="1">MSTVLDLPFKTLRPRILVAPSGFKECADPAQVADWIEKGLRRVMPHHSTEIQTWPLQDGGEGFLDAMVRKWNGSVLETRVFGPMGEEIEGRIGLVDDGATAVIETAQVAGLRLIPPAERCPTLTTSAGVGMLIRKALEETLVTKIIIGCGDTGTVDGGIGLLRLLGGEFWSGGKELKTHLISADLEHIDRIDLSRVHWKLRSKLVILDVVCNIHNVLCGLDGMVRIYGPQKGVKPEDIEPLSSAVDKFAAVAKRCTGMDVGNMPGSGASGGMGAALLLLGARMTDRRAAFHWYFDFDSIMAQRWDLVITGEGRLDKQSLRGKAISEMAMAAKERGIPVICLAGSVERSNNYTDAGIGVTFPILDRPMSTTQAIKRAPYLVMDTAERVARSVLVGWEMARLMDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYV8</accession>
    <name>A0AAE0NYV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_519428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="86" mass="9636" checksum="A6124D50CFBE222E" modified="2024-05-29" version="1">MSVPQSDAFKKAAVDSKKLTSKPSNEDLLEIYALYKGKAKYNAWAKLADESLTPEQAQEKYVTKIEEMKEAYGYDENKEPEAVGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYY6</accession>
    <name>A0AAE0NYY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_519471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="379" mass="40527" checksum="EAC6E01B1AEC13B2" modified="2024-05-29" version="1">MASPQKIRTPLTDAFGINHPVMLAGMNVAAGPKLAAAVTNAGGIGVLGGINYTPDMLRDQIEELKSHLTDKKAAFGVDLLLPQVGGNARKTNYDYTKGKLPELIEIIVESGAKLFVSAVGVPPKQVVERLHKAGILYMNMVGHPKHVKKCLELGVDFICAQGGEGGGHTGDVPTTVLVPACVEACKGHVSPLTGKPVQVVAAGGIHNGQLLAAALMMGATGVWVGTRFVLSEEAGAAESHKEAVRTAGFDDTIRTLIFTGRPLRVRKNPYIMNWETERQQEIRELTSKGTLPYEADLDKVMNGDAEEAAAVKAASALKATNNVEEEADDDDILDQFRPYLMGQCAAVCNEKKSAKQIVDEFVNDASEWIQKGQTYVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ44</accession>
    <name>A0AAE0NZ44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_109869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ44"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="32472" checksum="780C24E508AC2DA5" modified="2024-05-29" version="1">MMSCRTEARLTSGIQTDRSELPCGERSVTGMSINGMLDSMTETKTVGGDQRGCERGRHGHLHDGCSTRTAWRGWGVGDISGRRASRQGWRYGNGPCPERGGQGRWIVNVLDMALSENGWMALWEDLGWAAAACSSPHTPEPLGSELRAPWASGTVRLCLRCVHDEACFLWSSSFAILTVSASCYVPYSAREGPERAERAKRAKGYPIRAGAQIGNFVGRFLLPPGTLESIVCRLGVHTEQEVVRELVDQDGFDWRLAHPFWYSTISSIKFILRGQYIRRDGRHIGVGARRRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P073</accession>
    <name>A0AAE0P073_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_539310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P073"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="207" mass="22683" checksum="D90BCC501984190E" modified="2024-05-29" version="1">MVEPSPKTTSTTASPPSHPHISQASDILQDPARATIPRYRAYVHARNRFWTAFPDGNFIRLHTGSTNLECAFYAVVLSMAHQTPSSFEPQPAVDELREIFFSTVLAGRNESAGLDNENNLGADQIAAVFSEWGRGKGLRCQLGVVTPVDDDDLVPVMMNTPEADKSDPDEGIVRVWVYNDGWSLRGGMGHFEGIKRPGGEEGGEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0L4</accession>
    <name>A0AAE0P0L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_558044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.90">
        <property type="entry name" value="Immunodeficiency lentiviruses, gag gene matrix protein p17"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012344">
        <property type="entry name" value="Matrix_HIV/RSV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139019" checksum="7AD9206277BFF57D" modified="2024-05-29" version="1">MELFSIEAETASLLKDMSNEELCSFAELHDDPAIGGQIELYIYTCFLLFKKSVSTEHLERAAQRAEGWVAVTPTDHPDRIRRSRIFDMMSACVHHRSIPESTILTTPGVTQRMGEEPAVDEIGIQIRHLSHQAERLAESYQQTGRLEDLREAVTIMELALELGGAHIEPRMLSNLGAMLGMRFDRTGSIDDLNRAVDIASRAVDTTPQDHPDRAAILSSLGNSLGTRFQRTGSIDDLNRAVDVTSIAVDITLQDHPDRTTILSGLGYWLGTRFQRTGSIDDLNRAVDIASRAVDTTPQDHPHRAAILNNLGNWLGTRFQRTGSIDDVNRAVDIASIAVDTTPQDHPDRAGRLNNLGAMLGTRFQRTGSIDDLNRAVDVASIAVDTTPQDHPGRADILNSLGNWLGTRFDRTGSIDDLNRAVNFASIAVDTTPQDHPDRASRLNNLGNWLGMRFQRTGSIDDLNRAVDVASMAVDTTPQDHPDRTSRLNNLGNCLDIRFQRTGSIDDLNRAIDVASIAVDTTPQDHPDRARWLNNLGNCLDMRFQRTGSIDDLNRAIDVASRAVDTTPQDHPDRAAILSNLGNRLGKRFQRTGSIDDLNRAVNFASIAVDTTPQDHPDRASRLNNLGNWLGTRFQRTGSIDDVNRAVNVASIAVDTTPQDHPNRAGRLNNLGNWLGMRFERTGSIDDLNCGLSSYKEGWSCHTAPPSVHIRLARATANILALQREWGESSQLLEEAVKLLPTVSPRSLNHTDKQHMLAESAGLASVAAAAALNAGKAASHALQLLELGRGVIASLLMDMRGDISDLKREHPGLADEFTSLRDELDSPSDRLTPTISNDSTSSWESQAKRRREADQKFGELIAGIRTRPGFERFLLPPAEDEIMAAADPDPIVVVNLSSYRCDAFMVEHNQITVLELPGLKMEEVQERAQDLRSSRATGSFHITPLLGWLWDSVAHPTLNALGFNDPVSDDKWRRVWWIPTGLLSQLPLHAAGLHMRGSTETVLDRVMSSYAPSIKALIHGRRVPIRESAGPFTDYALLVAMRETPGLATSRILPFAGDEVEMLKSLCRSLKLGSLTPIMRKDNVLQHLQTCKIFHFAGHGQADPADPSQSCLLLEDWKTSPLTVGDLRDHRLQGNGPFLGYLSACSTGSNEAVRLADEGIHLVSAFQLAGFRHVIGTLWEVSDRHCVDVARVLYETLRDEGMTDIAVCRGLHRAVRALRNEGIKDEKEKDGKARDATLEFSGSRVHEMANPHWVPYIHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P101</accession>
    <name>A0AAE0P101_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_447314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P101"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="10925" checksum="F06834894B11AABB" modified="2024-05-29" version="1">MDPATIISTTSAILSFVTAAKDVCKFVKEIKDNGCTLTVLETSNRIDTLTLQVDKLKKGSGTEATGVAVNVNDEQLDNLAKGVGKDCSALGSAQGADDPPPYHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4I3</accession>
    <name>A0AAE0P4I3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_516316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4I3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041914657" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="27549" checksum="9D56A03C3FA2876B" modified="2024-05-29" version="1">MHLKTICDLLVVGLSAISVAEATFVNGGIVVDRNGRQIQRRQESDESKTANAATSSAPTSAPTVPPSPSTSSTPAPPKSTSTPPSPSSSTPPPPPPSSTPTSAARPSSSSPLPPDVTSSPPAASTTPPPETKDSTTKPSQIVDTITETFTSTLEDGSTITSTKTSTKTSNPTLSDGTTNQSQGMTPQTRNTVIGVVVGVGGAIILAGLAFVAYRVWGRKKSQLEDDGLGDYTSTADKSEATGSMSGRTPFQSTLESYHAPTQVNTASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4N3</accession>
    <name>A0AAE0P4N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_13868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="24543" checksum="4CD8B322EB70B921" modified="2024-05-29" version="1">MAPKANISKRRGAKGTATTLASSSSDSDDEYHAYYQKLQEASNARIRLEKAKEIRNMKRKELADAHKATLSDIQNRIQKSVALYQDTYAKMHVKRLQRLLDAIQARDKTFSQLEEKIGDLRQIMKNHGVQLRALYQGRHNDMMKLLKMPPVIATKNPHGTEYQEKVPPNPKAPAPPLKGILKHTTAQPRVNQALLDKITARESGERRNLVGVHCSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5K6</accession>
    <name>A0AAE0P5K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_458860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5K6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3393695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="178" mass="19202" checksum="F03BDE01600D99FF" modified="2024-05-29" version="1">MMASIARSALLRQAASASKLSLATSSAARQSIIANSVRASAFHTTSRRNLLPPLPQRVEGTVNDPAPVPEPSPSHGSYHWTFDRLVAASLIPMTITPFAAGSLNPTLDALLCATLLIHSHTGFQAIIVDYIPKYRTPRARKVFTWGLNAATVVVGLALYEFETSDVGLTEAIKRIWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5T5</accession>
    <name>A0AAE0P5T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_459340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5T5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="222"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="488"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3393829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="732" mass="79625" checksum="B81707A8E35A48D5" modified="2024-05-29" version="1">MDILKLLSRGTKPNPKKNAQAASATQLPSAGSAPNPQLYHDDVGDSRGKKRKRRGQAQGDDEVHDEDDLSDVDYFAPKAAPGTESHSASSAPAKPEPPKRKVKLLDEDECRQVFRSHRLKLTVLSGRTEKEAPKLSKKAKKDKKDKAAEGDAKDKKDDKKQQFFPQPLNAFSELRNIYGVNPELVDNMTRQGFRVPTEVQIASLPLLLHPEMALKRTTDVADVDITRGIDFLAAAPTGSGKTISFLIPAIDGILRRRGEGFTDHVLEALIVAPTRELASQIVNEGRKLALGTGVRVVLMKKTLRLGAEEGEEIKPDSDAKADSDNESEADDAVAEESAEEDEEPDAEPAADKEAGPKLPAKVDILVTTPKILLNFLAATKTRGKKTLPTVRSLILDEADVLLDQIFQRQIMGIWRACTNPDLSLTCWSATIASSVEAIIEQQLRKRARRTAAPSRPLVRLVVGLKDTAVPNITHKLIYTASEQGKLLGLRQLLHPVSSADSGPALRPPFIVFTQTIERAQALHDELKYDIPLEAGGSARVAVLHSNLADSARSKIMTRFRAGEVWVLITTDVLARGVDFAGVNGVVNYDVPTSAAAYVHRVGRTGRAGRAGGVAVTYYTKDDIPFVKSVANVIAMSEKQAGQKDGEASTVQKWLLDALPKVKKEDKRKLKTRGVESRRTGGKATITTTSAWQRQKDNNKRGAIEGSKRRKKAEQQKASADGGASDGEWGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Z5</accession>
    <name>A0AAE0P5Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_30854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Z5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="429" mass="47054" checksum="1FA8F14A3110B2F5" modified="2024-05-29" version="1">MASENLPGESRAYQIQVPCIVFFVLTPLFVAIRIWARVKLRGMAGLGWDDWTILASWVFATTVSALMMAACTYGFGQHIANLSRPNKLMTLKLYYVAQAFYKLTIDLTKISILLLYLRIFIKKWFRRACWTLMVIILLYMVATTTVSIRQCGPVARAWDKTIPGECIDITANWYANAAFSVATDIFILGLPMYPIYTSQLPASQKIALVVVFGLGSFTTVTSILRMTTLSFSSTSPDTTFDMASSIWTMIEQNFAIICACLPVCRLPLSYIFPTQFSSPSGSSSAGGLKQRSVDSCSSSESSSTTRPRPGTAKCTCTRQPTPPGIVPVPTPAFASFSAPKKWPIPALSESQLEKDIVEIPESQAAGWITDDEPGENVVSHASVTPWDEPACARHSVRHTSARGIHMMTHYSITYDVEKADDNVGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6B6</accession>
    <name>A0AAE0P6B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_517289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6B6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="30409" checksum="0FDDD6191031FB22" modified="2024-05-29" version="1">MQRESKTFLARLCEQAERYDEMVTYMKEVAKLGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSDKHVSTIREYRHKIESELEQVCQDVLDVLDDSLIPNAATGESKVFYHKMEITTVTLAEFASGEKRKVAATAAHEAYKSATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDSGEADPAAADAAKVDEKAAEKEEEPKDTDTTAAEPATSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P737</accession>
    <name>A0AAE0P737_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_49370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P737"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="254"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="347"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="351"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="483" mass="54336" checksum="D73A3D7B4B5AD858" modified="2024-05-29" version="1">MPVRTRNPRSLAISNENDENSNTGSTRLTRAKAATLNVDELAVPTKALQSKKSTINANPTRKRAALGDVSNVTKVDDGKKAVGKPGLVSKAAHPTGIQKKTTARSSALSTRPTNVKVAPKASGPGSIGAQKRKEAPRFKDDIPEEGEPVRKRPSTKLDAEKTIKAAEPVKVEAPPPKDVVVVPVEVVNDEDEHVYPPGVKDLDSEDMDDPLMVAEYANEIFEYLRDLECNSVPNPQYMSHQDDLEWKTRGILIDWLIEVHTRFHLLPETLFLAVNIIDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHIANFSHVADDGFSESEILSAERFILTTLNYDLSYPNPMNFLRRISKADNYDIQSRTIGKYFTEISLLDHRFMAYRPSHIAAAAMYLARLILDRGEWDETIEYYAGYSEEEIEPVFQLMVDYLARPVVHEAFFKKYASKKFLKASILTRQWAKKNADLYGITDFHLSLDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7A0</accession>
    <name>A0AAE0P7A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_460609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7A0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="420" mass="47966" checksum="1A1B4169A78895CE" modified="2024-05-29" version="1">MTVKNPYNFPKPVRAKLWMVRILGEGILLSEGDEHIHQRKALTAGFSIQSIRALTPIFWEKSLMMAGLWRDEMQTANLTTKSFEVLEWLNRCTLDIIGKAGFGYDINSLEDPDVPIREAYRLVFAFDLFSRLLHGIQAFIPASKHIPAKMNRDMETSRGIILDKATEIITTKLDDAENNVGKKDILALIAKENKKLKEAGEPGLSFNTMRDQIMTFLGAGHDTTATGAAWTIHLLSTHPEVQSRLRDEIREHMPFLFDKDQRFDTQKLAAADPDKLPYMDNVCRESLRYIPPIPMTVRQSLEEDYLGPYKVPGGTVIYVLANTINRLPSYWGETADEFDPDRWDALPETVVPNAYMTFLQGPRGCIGRKFAETEMKILLCCLLSMYDFERDFDTPDPEEWKMWRLVLRPKEGVTVKATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7H9</accession>
    <name>A0AAE0P7H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_387676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="125750" checksum="30BFE7D4513D2F8A" modified="2024-05-29" version="1">MNAIQQRCRPKHQVLVLKCYPRTTKGAVDVKPNSSELSYLLFYAQSRRSKIQKVGDFLEKKTASDVYRLRIGNVQVTLQILAALVEKAPKDLPLLASSILRILEQILKSNDITMVESSIPTFEAFCEHHDPTSLLGDQVYLRQYLSVVQQYAALASTRTYPGKTEPSKPIALRWRNSGLEAIRSIASSDALSSVTSRQYDVAVPMILENLWTDNEDFLDVLLQRAEDDDRADGGALLRRRTSIATVRTADTSGEAQPNPIALSGTAVDVDKLAEEDIGVLAMQCLKQIFSVTNRTQVHVATAALLKFTEERIDQQEDVVKTNNSGKDSGWAIKMFLLVARWTPVADRFTILVTAMEMLAQQPLTDDRLRHHIVLAAMIGALLRSDINLIGLSVMDVLLQLIAHIRRLVQMPGDPNSMRSEPPLPGQPDPRSPTTLQFAEKADRAAAQRKDLLLRLQECIGDLATHVYYADQISDMISTILLKLKPSRSNSTSSSSPQGEKAENSAAAPADDQPLDSLFSLTVAKIAALRAIKSILLVANPRAKMSGNYALSRNHVPIQVWEGTQWLFRDPDGLVRKAYADAVATWLDRETTKADSKARDETARTTLKNRDIPGGTLARRVVSNASARGEKPVKVPRSHFLQLLHLAMYDNAIQFIDYETDIVLLHVLLAKLVNQLGVNAVRYGLPMIFRLQEDIQDAETPIAKVRLGSLVHGYFWILTEKFDFEGSVVGRAIHNEIVRRRSKHFWVEGIYMPPPLIELVGTPGMARPQPRLPLDEIESEALLPFDDRDGLVECVCNGYQEAAISPPTSPAASPGRSFSHPVLGSTLSTIPAIETEREIPAHFREQMLTDWSREAIMAAVQAGSKSASLNGSRSGTTGTNRHRLVANGGLSANGHVPVTRTPSPFASKTNLRPSSSPAGPDAAHHGVKLRKSSVRSNASPARKNTESKEPVVASVEQLKLVLSGHLQPPPTMSGIGYQKDDSSSSDSLVSYDLTPSELSFNPAVVGEQQPVATDGLDTSARPVSRDRKQQQVPYLGGPLSSHPTHESTSDHGGDEPAHAVPPVPPIPSGLDGRVSRTTSNKGDYAAATLPRPATSKRSLKSRAGEQRGVSSSWGLDDHNRLLPAMDLQSLLKGIDSQAGERSLGTITKPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7P7</accession>
    <name>A0AAE0P7P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_58179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="36830" checksum="4FBE4F7FCA22C46E" modified="2024-05-29" version="1">MAPNQSKKPTNGMSEKTPLVQNDGQYRPPTTGVLSKLPSSWVPYAELMRLEHPHGNYMIFFPHIVGLLYASSVQATPVPLATLAHRATVFLVWTFFMRGAGCAWNDLVDQDLDRKTARCRNRPVARGSVSTAEAVIFSIVLGALGLASLQFVPRECTYVALATFALTILYPFGKRFTYFAQVILGSTLASTVSLSAYSVGLPAVSASYVTPTLCLSATIMLLVVFYDVVYARQDTADDLKSGVKGMAVRFRNHLEALFATITISIVTLLTTLGASVGMGQFYYMFSVVGLTMGLVSMIALTHWHLLPSWAGMSGWCYAFAILNLVGGFVMEACFKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Z3</accession>
    <name>A0AAE0P7Z3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_408293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Z3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="49988" checksum="54E14CE3E631788D" modified="2024-05-29" version="1">MAATASSSAFPLQGVTIFQLRALCQVLWDWDLCEDCQNPRNSPLQQCRAAQCPWGQRSERLEPFFDLYRDVTGSYVPDFFGDEDQALRNHQDLSDIILLLRQKGATLSRNECKYDYFTSRGNDETTIPQSDQDRAFDLVARVMTMAKVNSSEYDQDDDVVFTSRDEEDQQGQKLLSPPFIWPPEKSLQMALADSFPVRVHPSLQDNDSQAKNIKARLTAVNLTRIARLKIEGTNDLQHHLRLDQATGVVQVFHFTSVLKEHLLATKPDVNRRRRSNDSDGQEKAPSSCLPRPIALETLYSIQLLFPRDEKSQALLRNLVSKHGFDPDCLRFGTAPFECRAPLPRRPSDGVITETVVDEKHQALRYPIWGSRLMDLFDEIENPKPRGLLDAWLERRSKSRHVMLATLAGVAAAVLLGLLSLIVSVFQAWVAWQQWKSQNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P880</accession>
    <name>A0AAE0P880_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_427147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P880"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041939197" evidence="1">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="260" mass="29519" checksum="C61DC64383378E8F" modified="2024-05-29" version="1">MGIKRLIILLVTLLAAAAHTSYAYQIFSNRGTLGGWTAGTRAEHNGKVEQVNTASPWSPTSLRMTQVYDYSPSYKNGRYHSEARVASGYRYGDTRYYGFAFRLAPNWQFTEQSYTLAQFIGNFNGQCGEGYMPSTMIWIVGNRLYTRRKWGSVCDQHSTTITTSVTVEPGKWHRIVIQALWTNDNGGFLKMWYNDKQVVDRPNVPTTVKEAGPAFEFRVGLYANGWHDDHPMKGNQATRQVWYSKIAIGTTMGDVDPKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8C4</accession>
    <name>A0AAE0P8C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_462756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="22047" checksum="FE58FCEB708EB084" modified="2024-05-29" version="1">MPPRRGLYVVRSRIISEAILPPATFHQWYEEIHIPDVLNMTIINSSFRYAISDDDKNKSPIPYLAIYPLADLAWFYQPGCPFFKVPLHSDLLPNESKFIFDVAAFDMSFYERLVSVGEDTGGPAKALVLVFYDEDVAEGKEAEFLLRKSLNNESLKPLRSTLFRLDTAPNPNREDSNAPGVENKPKLLAIVSAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8J8</accession>
    <name>A0AAE0P8J8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_462995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8J8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="589"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3395293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1260" mass="138583" checksum="B429AEB615346C77" modified="2024-05-29" version="1">MTTANPPPLSETARERETFKYDDLGISTAALRSSPIDSSLKPIPTAVLSSTPDPGLTAFAQLGLYRLDAARSMVSLFDRTYQHFVAEAVRCSPLCKESEALSDGQAAFCGTAIPRIGSLCEHVLIGPAEFASVPGTPYGYKPSSLPVSVIPNVPLDPRFRHIRDDRRFYAGVPIRSPTGINIGVYCVIDDKPRPEGLTDDQIQFVRDISKTMMDYLEAKRSSEWYRREERMVRGLGSFVEGHATLSNWSDSPNRAFFYDIPGVREGILNKKLQAAPPDTSPKSCPHGINPELTGESVDCVDPIPTPIPVLPPALEFRPRPRRATESASHFTSADQLQDDVERVFSKAANVIRESVEVEGVLFLDASVRSFGGMIGREISEPPILTKLSSAESSSDEGAPPVPGDTDVDDCNVLGFSTSSRSSINGDQPVHAHAAMSERLLHRLVQRYPHGCIFNFEADGSMLDQSNQDGEECFDTSPQWKRSFLIGEEQRGHDLRSKGSSQRLRRRRDTAASLLKMFPNARSVAFVPLFDGQKSRWFAGGFVWTKTPTRIFTVKNELSYLRVFGLTTMAEVARLNTKAADRTKTDILGSISHELRSPLHGVVGAVDLLRNTMLDRAQENILRTIETSGRTLLDTIDHLLDYSRISSNMRSSRSDRRNTAPFSRRNSKSPTITTLSTTDMHVQLDRLAEEVVESVLAGWSYRNMSDAHFAAWNSFMQGSQAGTRHHTPTGSDLDHVGTPSLVQIYLDIDPSVDWSFRVHPGAFRRIVMNLVGNSLKFTTSGFIRITLRQELYSNSQQCPSEKRVILTVSDSGKGIGQDYLRHHLFTPFSQEDQFAPGTGLGLSLVRQMAITLGGNIDVASQVGQGTTITVSLPLPQSQAGDQDEPTFDQNYKSLAGYSVCLRGFDSAIKIREGFHREDTKQKSPLKLIESICRDWLHMKIVPEPDTSVETPDFVVCREQHSTSVGDESKADFTRCPHVFIRVDSSNKHDLSKPKHCSSQGSLSCLTQPIGPRKLAEALLASRVRFNDDLDAMTSAAAPVLDQSEQPARSAMSSPGDVFINPMLDQTPLKPTSHTTDDHSLKRPPLISDKKMSVKGDDLKDGHEVLLPSLLPKPVVVPTSDGLVSAVSQAPDPRPKILIVDDNAINLKILAAYMIKLGQPHSTATNGLEAVEIFTKSPSEYSCILTDISMPVMDGLESTRHIREFERDRKLKPTVVIALTGLSGADIQQDAFVSGVDLFLTRPLVLKGLVKALESTGVRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVD5</accession>
    <name>A0AAE0TVD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_195760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="188"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="372" mass="41264" checksum="50878C6CE2600C82" modified="2024-05-29" version="1">MDRPTDPSTHSEGNGSSSGLREERVRALQEMYDAGTPIFKKADLWYIGDQIDDIQARPLDEVAGRFIIMPAMNRLNVVDEVMTGRVTNPDVSPDVEEVYTYPSVYYYSFDVRVANYEYGPADRFLFSPGEFSYGPVKRNKHTKELIPPTPDIPAEKVREDLKAAIQRWGPSEHGKAVRQILTSVITPSLAAKKVVAFALGSMATKGFVGNAANNYQHALLLLVQECLAAATANYDDRKPGCFAQDPAYLAEDKTVLHEAGITVLQDPRGFVEVDDEAVVISIAPDVPVKQIIADIARPAIIIWDRNSLQDYDAPWEFADPESSRVKNMLANEYTEVDFPHHEHLDGLVIYVRKPRPENGAHARIAGSPLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVF9</accession>
    <name>A0AAE0TVF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_397187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042009577" evidence="1">
        <location>
            <begin position="26"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="110"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="460"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="606" mass="62725" checksum="C187FC20453AFD05" modified="2024-05-29" version="1">MHISHRHAVALVALVAGQSLTGVLGDFSGPSFSAPRDLTSNHSLVKTAWKSVTAALEAHLGGVGTSNSCPNGSSIPQEARNVTFSIGLISVHDPDATSLQFHHTSPEIAASTQGTKKVDGNSIYRVASITKVFTVLAGLLTLSDAEWERPLSDILAPLSGQGGSGVLSTPWDKVSMRALAAQIGGVPRDGFPNLGEIALQMLLSNTTEAQIMAATGLPPANASDPLSVPPCLVPVLQGEACPAVPYLQGVANRAPTFLPWSSPGYSNNGFTLLGLAMANVTGQAIGKLYQDNILDPLAMASTFSDLPPTAEYPRSVIVGPDATEAGFAVPNGIFVSSGGVFSTTLDLARLSSGILNSTLLAPERTRRWLKPVSHTARLQYAVGAPWEIIRHVSPSNNKITDLYTKSGDAGLYSSWLVLVPEHGFGFSVLSAGSAPSRFGVVAALADAVSQALVPALHRQAAAEAGWNLGGTYRGTGGLNSTLVLKTAEDAAGVVISSWVSNGTDVLPFLTAIAGPGPHRLLPSVDNDAHGQMAFRLVGAQDSPASGGPEPGALFAAPGMATADWIVVDSSTYYGAGLSLFVFDVGRDGKATAVTMPAYRVKLPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVS2</accession>
    <name>A0AAE0TVS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_201118</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVS2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="359"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3381351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="723" mass="80947" checksum="789113468CD9BAED" modified="2024-05-29" version="1">MPPPRDSAHRRAKNHKKKKRPVSRDERPTTSDESRSAGTSSQGLSSAALAQLNRQNARRSTQEPPPPPRRDREREREIERERIRAREKELRRQREKALLESEEHHYQAKPRKRESTTRNAGYRDLGREEPPSRNPREKRRSGRVVSGAILEEGRGGGRGGGLRGGVGRPSSYDSLEKDGLYEDAPRKGLSRKKCWIIAGVLGVIFLIIIIAVAVVVSKNNSNGDGNGSGSSGSNDLNGISPSSIPAGAPSWLNPFVWQDTTGFNVTYTDATVGDLPLMGLYSSWDDSAAANDRVPALNKDWGDYAKRPARGVNVGGWLSLEPFITPSLFEYDLRMGIIDEYTLCTYLGSKCESTLEKHYATFVTEDTFKQIADAGLDHVRIPFSYWAVQTYDGDPYVFRTSWRYLLRAIEWCRKYGLRVNLDLHGLPGSQNGWNHSGRQGAIGWLNGTDGDRNAQRSLDVHDRLSKFFAQDRYKNIISHYGLANEPKMTFLSVSAVLQWTETAYNLVRKNGISKAIVVFGDGFRGLGNWQGELTSLSSAALDVHQYVIFNTNQIVFNHTEKVRYACDGWTEQTLESSNRATGFGPTLVAEWSQADTDCARHLTNVGWGNRWTGTFVGTGDKNTDTTTPRCPLKDTRCDCKAANADPGQWPQEYKQFLRMFAEAQMHSFEKGYGWFYWVWDTESAPQWSYKKGLAAGVLPAKAYERSFDCASSIPSFSGISEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ62</accession>
    <name>A0AAE0TZ62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_509802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ62"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="30902" checksum="751FBEC2ADF14FEE" modified="2024-05-29" version="1">MDQNKKPPAGPANIGSTRPSPALSNQAPNKSGGSWNGPPPPVAKPTFGRTTSNTSSGGTPSNAASGGNQSSAPSGGKPYGGGGLFGPPHPSLFGTVPPNTTPRPGFGGYAANNDTAFGTPITNQMTNLENTKAELFKLKENPFSTENAKAELFKHQRDEALSQKTNLETQMSALESQKATLENALRLITGRLDIQARLDMAEAELKTAEKETNELRNKYEKLVTEHKDLERRYHGQAAALHALRTLLSLDSSAPVAKPAEDVPISSVPDNRPANSPASGSAIRTSNEGNVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZS4</accession>
    <name>A0AAE0TZS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_414650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZS4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="59722" checksum="E29A0B8796C0261F" modified="2024-05-29" version="1">MAPRVTHDVHSHAHEEGVAGTVNLKAAEGEETHYGQALFPVPSSDPNDPLQWSSFKKGMILLCCSLYSFLGISTLIGPSVYIGLWSVEFGVDPNTAAGLINYPNLVFGVGSLILVPLYRKFGRRPVMLGSLVFYAAGVIGASQAKTYEGLMTARVIHSIGSGVCEALPVQLVNDIYFLHERGKKLGWYTVALCLGATGPMFSGFMLAGGYSWNLFFYVEFAFAVALLVFAFFVLEETRFDRSAALTVSTPISGTETNLAKNTSGEKLEGSAEYVSERAPSASIPPRKSFLQQLKPWSGIDRESDFFMMMARSFTYLFVPSTFWVITTYGIYIGLCGFTFNFVFPLKIVAPPYSWPETNSGLSSLATIIGFGLALPFLPVSDILAARLTKRNGGIRESEMRLWVLLPACFVAPAGQTLFGVAAAHDLHWITYFLAIAMTQWAGYFYFTLTLAYAVDSYTANLSEMLIMINVGKQLVSFGLSKEVLNWILENGYVKVIVGAFMPVLIVNNLMVFVFLFWGKKIRVAISKTKLASLHANTALKGETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZT0</accession>
    <name>A0AAE0TZT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_184742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZT0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="19529" checksum="ACF93A70FFFA1B81" modified="2024-05-29" version="1">MSASHSKSSRSSPKFSRRSPPLVTVSPATSTGASTSTRQSPYDPSPNMWGVPRSALSLPTNTTTSTAQIATSPPETKISKTAEKQEMARQRVNTFRADKEYYTCYVEDISDKQRDGDSPALRRQSMRDRIADVMDPFNNGTDDTSWYSSINRIYYPIMLPELEQWRPDNCGSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZZ9</accession>
    <name>A0AAE0TZZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyoverdine/dityrosine biosynthesis protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_449799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="134" mass="15333" checksum="F3EE129FD07ADDA0" modified="2024-05-29" version="1">MALTRLRKSVEEIEKIYEPGARIRIVSDGHVFSDCIGVDDATVDKYGAQLKEMNHMLMASFKPQESTIRAQIESQDAAILALYRGFSRFMLEDLETRPATHGLSRSQQRKLVKRTSFEMIMVRVMHDARKTGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1Q2</accession>
    <name>A0AAE0U1Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_509510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1Q2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="361"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="743"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="839" mass="93597" checksum="B81BA9C1B04F1F44" modified="2024-05-29" version="1">MDPISIATIVVQTTASCLKTTKSLYDLNEKFKDAPMAAVSICSESSVISASLAQIQGLLLQRHDLADVWKSRTELPVVLDNALTGCMVVFSCLDAEIQRIVAGASDPSKIRWRSRARLLWNETKLNELLSSLRGQQTAINLLISLLQMDTLNEIKHMLWQRQDTVRTSANITQSLRSNNPSIRVTNSIYGGNDDNHPGSTIMAFEHDAVSMTAPSELEFDFDDMIINSQAYRRAFAQAHTHALVGATHQEDIGDLIDLTDNLTFKQEVTSASDEPLPHAFQDLQDLVFHETPARSQTKDSVGHDVKVAETNQVETTALMVAEPEDMDVTQSQSRSTTPTLLIRRDEPPTNPPPQRPKAATKICHKCSKVITGQFVRPQGMNNQMFHLDCFRCADCSIVIAAKYFPLEDAPSVRLCETDYFRRLNLLCFSCGGALKGSYITGLDRKFHIEHFTCEAPGCDTIFGEKDSYYETEGGDIFCGFHYAAVARLCFGCCIPIFSHFVEKEENQVNAHWHPDCYMIHKFWACKMSKIGARIKFTDGEWMMTTRVSTDGSGSSIIDKDALLPLFSVVENEIYQVWSILSEFEEGIVASFSDAMRHLMEGDGDEFEAASKMILRRATVLFKAIRLVVPHPQGNKEAKLLCKKTVRLFSLASEKFRAPPKTPTTTENKMTQEIKTLVSGLAHYTKWLIKIGLSTSVESKATDPQDGSLVLFLDALSTWETTTDSSDSLIRRVNEISLYSATSDLCQACNNYIESRCYSSGPAGGSISWHEACMRCQACGKVGGYDFGDMEERVVLEMSSINCKFCRLPAAGPIFFIPQLSQYSFLLHVALARLLKFMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1R3</accession>
    <name>A0AAE0U1R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_470974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="49480" checksum="A7551C009F4F4777" modified="2024-05-29" version="1">MLFSPSPLSFFLLSSPPLISPHIHPHSDKKFPGIMPETGKKPKLHYEWSHIFTLWGYQLLKLMYTSSALCIPWLFLSLTPVLWAPYNWLFWLSMISADGVPNFAVLSDDALLGNTIGNLDPPGRCMSRAEKINATLSTSVDEVSGWYGPGAYLAWLVTAYVASFGSIWQSKCARSEALREKDREREGRADEFWSMLSLPRFDSGSTEEPENVLDGETLAALLYPLIALCDVLVRFIRCKIDPGINAAVFVLFSALMIFGPTSRLSWQVDGVDNDLDFLPKTNRSWAWKFSGFMIHGVIITIIGEPYSYALELLIPVYVMLFALMLYSLFAGEFLSESYPYRGAVYRPRAERCLMFGLLQVVFFSVAYGKIGTVWPVTGSSLSELDQAGTLCVTVLTLLYLKLDGIRSLVSGIKHRLSGFRQVRESENNGGMELQEVVVHGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1V8</accession>
    <name>A0AAE0U1V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_542267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1V8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="695" mass="76440" checksum="9AA786477A8203C5" modified="2024-05-29" version="1">MSGQNLKDIDNGQGHTTFKTPILPATLTGDDRLPRFGSLSSCKIDDAREARLWELEAIRLLESIASAQVPLAFSATSQFPNEIGRLGFEKLAAVSDRLLCAAAVCELEDQVMLVRFNSYGRLGSPFAMTKSFQALEERLRFQAASEAPVSDAESMDYYLLVDYITVTLARLLASGVAQEKMTYWHCIALTSLAKFSAKLKVLSHNLPLYGREVIRQPMIQETVYQLRGSSMDFVDPSLRFQDAQVTNYLSDMSEVSEWLFHIVWEVVSDLATRTTRGWALDEFDIAAMVCGTGLRLHLTIIYQNRRGYFSGSPSGISVGLCHWAFGILADTAEAIRQKRSEETQSDFMLAPGPVGSRTTLELGLRSMAELVSIMVPLSFMGPTAAAAVFRLHGAASASATVQRIHNASWGFAAYASLHNKSSTRPGEEGSGPTATSPSYSCPLSNAMTTWKTTKQTAQQRQTEGWAIEEMAISVGCLRYTLGVMSACALLVAGGLLAGFLVGSRIDGVDPFNLAMFSWIIAGFSLLVAKSVRVAEWPWRDFLKGRVTCRSVQELASVTGLDEQVIITHLLSLESRTPLRTRGPYNVMFNKAGEDGFSIDVSPRVDTLAASGIIIVEVLAARGPVLVCLDIRPGPGDDNLRFDTLVHSQFEERTMLVCVDPPRQNDSELKPLSFLWLRIRWEKVIGVFNNPERTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3F5</accession>
    <name>A0AAE0U3F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_94936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3F5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="564" mass="62546" checksum="2A000EE8D98ABC3A" modified="2024-05-29" version="1">MPAQYSALRLIAASFNEREMDERERHSGLASCILRLYSGMMIGIRLFLLAKDRRIEVESWMSASEHAPLPPRVYPSQQLMLAAGILSMVFVITSTPLSAVGRAGLSLAGIGDLVVLALMITATVFQLSYLPASDSGCFPYTGPQSVLDMFTGIGKENNKTPGDVCKEYSGSCQLAFYSIAGIAPGALIGIFAPNILGILVLTFHLWIIPALAILVGVGLWKALKYAFIFFIAPFLYIISKPLRVLFFVLGRIPAVVRYKKRRADKFRQTAGCSDMEHLLPLVHHCKERFNESDLTLVSARRQTSHIPRSGPPVLSVTLDSAFEKVFGRDEVILAPLIRNCHFVDVLQLSRTSKTLRSAIHRALAAQLPLLPPLRVMTCWRGSKSSCWGCGVQICIGCKSTVEVPVSMTPLTTRHLNVCEARCVRCYVDKMCHSKSSGSRTRPCEHLKPTIAITATMAAEDDDDEVVEEEKQEQVVCSSCAAAAAEELRENREVREAKELFYLAKSTVSCGRCKRLLEDTGPRWWACCECGAECTSHYHPPWRGQYHHDGKKMGRMQLLSALFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U438</accession>
    <name>A0AAE0U438_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphate metabolism protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_110457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U438"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="191"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="397"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="769"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="96699" checksum="0903BA93EBB75EA2" modified="2024-05-29" version="1">MANDTDTKSTPPASLSGMVSTLVPVLIISAVYFAVFLVLRRSKRRYYAPRTYLGNLKESERSPALPTGLFNWFGTFWKIPDVYALQHQSLDAYLYLRFLRIAMILCFVGCCITWPILFPVNSTGTGGKAQLEILTYGNIGTDQKPRYYAHVFVSWLYLGFIMYLIMRECIFFINLRQAFLLSPQYSERISSKTVLFTSVPTPFLDETKLRKVFGQTVKNVWITSDTKDLDKLVENRDKAAFRLEKATVKLIKLANKERQKAIKKGAAADEADKAIVPGDAESGSIAARWIPEKKRPSHRLGPLGLFGKKVDSINWCRTELERLIPEVETAQAHYRAGGNKKIPGVFIEFRTQADAEGAAQILAHHQGLHMTPKYIGIRPSEVVWKSLCIPWWQKVIRRYAVYAFITAMIIFWAIPVAVVGVISNVNHLKTLSFLTWLDKIPVVILGVITGLLPAVALSILMSLVPVVMRICAKLSGEPSISRVELFTQNAYFAFQVVQVFLITTVSSSASAVVQQIIDKPTEVSSILAGSLPSSSNFYISYFIVQGLTIATGVLTQVVGFFIFSLLYKYLTGTPRAMYNKWTTLSAISWGSTMPVYTNIVVIAITYSVIAPLMLGWATIALALFYLAWRYNILFVTDTQIDTRGLIYPRAMKQLFTGLYLAEICMIGLFAASLAPGPTILMVVFLVFTLLFHISLNSALDPLLYNLPLSLLAEEEETRLLGPEVAGGVAAGPSTSHDTEKVVNGDGVVEDATVAAPKAAGKKPNMLAKFLKPWIHSDYETLRQLVPRGVVLDPYPEDVHKNAYFPPSVNSQTPLLWIPTDLAGVSKQEVAHTSKIIPITDEGCDLDEKGSLNWDTDSTRPPVWQEKILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U485</accession>
    <name>A0AAE0U485_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_519568</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U485"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3390336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="331" mass="36070" checksum="72E953BACE058CF8" modified="2024-05-29" version="1">MSGPSSPPDSRAPKGILKAPKSSLASFFNATTTPPEPSSSGGASPSHTALPREHQLAIAQAKRLAQLRDEEIKPAIPLEIFERLSTFPLTSSPASAPSPADAAEFISSVCDFTPMEYLDLIEERNCLGKCGYALCARSRRNYEGEFKLQVSTGTIARTEDLNKWCSDECALRALFIKVQLDNPSYLRKDGKMVVKVELREEKNKKSAEATGKSSVATPSKDKRSTTASSAAEEDTELTQAMDMLELTKENRDAAALSVERGDGGRTSRPGHLFNLTIREKSSVAPARAPDPEDHNAHHMVEGHRITFGTDKDNRNKNGDSDDDDLFPTIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4B8</accession>
    <name>A0AAE0U4B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_519691</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4B8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="478"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3390471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117787" checksum="3CDE7ED6EFBA95CA" modified="2024-05-29" version="1">MAPKKKSGGKKANDDWEKDLGETIAPAAATPPADGDAAVGDDEDAGGAGGLMALMRKNKEKRKKKGLSEDFPLEEPQPAEPVPDLTAKAAVEANLDDEFALPDKKGKGGKGKPAPKPADAPPADTPAKDEDGGEDGETGGKILTKAEKEKQKKEREKQRKKEQATPAKAAAEEKKVEAAPAAPAAAVEAGGKKKKLPPHLAAIQRQQEELRRRAEEEERRIAEEKARIEEEERLAEEEAKRVAEEKARKKAKEKERIEALKKEGKFMTKAQKEEKARNERKLQQMIAAGIKIGGPAEGETEEKKKKTDSRKRPGRKADKVDEEKVLAEAAERARLQAEAIAKEAEEKKRLEREQAEAEAAAKAKAAAAEDSVDEDWEAAAASDKEDVKDSWDADSDDEAEQKTAEQKAATKESKQEQGEDSEEDSEEDSDEDSDDESSSEDEQATAAQIAEAQRKKEAAERREKAHQAAMAARSKDDLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVESIKQKTAVINRDGSFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMKLLRDRKTPFIVALNKIDRLYGWKKIENNGFQESLALQNKAVQNEFKNRLEQTKVAFAEQGFNSELFYENKSMAKYVSLVPTSAHTGEGIPDMLKLIVQLTQERMVGSLMYLSEVQATVLEVKQIEGFGMTIDVILSNGILKEGDRIVLCGVEGVIKTNIRALLTPAPLKELRLKSAYVHNKEVKAALGVKISAPGLEGAIAGSRLLVVGPDDDESDLEDEVEADLATLFSRVEKSGRGVSVQASTLGSLEALLDFLKDCKIPVANVGIGPVFKRDVMQCGTMLEKAKDYAVMLCFDVKVDKEAQIYAEEQGVKIFTADIIYHLFDAFTKHMDELTEKKKEESKLLAVFPCVLQPVAVFNKTGPIVIGVDVVDGQLKINTPIAAVKTNPTTGLKEVIQLGRVTSIEREHKQIPVCKKGQPSVAIKIEMGGHQPTYGRHLEEGDTLYSLISRKSINCLKEFYRKDVSNDEWQLIIKLKPMFDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4F9</accession>
    <name>A0AAE0U4F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_538516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4F9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="577" mass="62082" checksum="827775B9CBEB1AD9" modified="2024-05-29" version="1">MTESPEKQAASAKSILADGDEAKARPTSRLRDGESDGVTTSPDSRGHDGREIPAGKLMSSKPAFGERPACFKNTWQEVAFVFQATNATAASSFFQGASAIITASIGRDLGMSQGEITWITASTALTAGAFQLGLGQLADLLGRRIIFITGMASFSAFALLVAFAQNPFWMDVVCGILGVCTAMVVPPAIGIMGAAYEQPSKRKNLAFSAFSAGNPLGFVFGSILSGIATKIFNWRAAYILIAILWAIFTVMAIWTIPKVEAYPPQQPFRDRLKTFVRTFDSVGTVLTIFGTGLLTASITLGPTDGWKAAHIIAMLIIGMVLLVIFVFWERVYPHPLMPPHIWKDRNFTFIILTCLPGYMAFISAQFWLSFFMQEAQNLSPLDVAVHLLPQAIAGLIYNIIAGSVLHRINNTLLLVLGSVAYIMANVLLTLMKPDSLYWAFVFPSLILSVVGADFHFNVVNMYVMQSLPSHQQALAGGILNTLFRLGAAVALGASTAVFVSAKGTPEAMTDPMIPYKQAFQVSIGLSAASFLFLPFVRLGTQGHSPRDADVGTRDSKEEGAVALAPAALSVESTDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4L7</accession>
    <name>A0AAE0U4L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_446867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4L7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="19268" checksum="8402A11B5DF340E9" modified="2024-05-29" version="1">MASNFPTPKLVKGGCLCGALRYQVNFPADHDFIASSSTCQCTQCRKQTASLFLLSHNAPDAAFQLTGDLSALKHFNASPSAERGFCSQCGSFLYWRPKNRPNPYYCFTVGTVDPLYLFGEGADGVETGGQDEPVPKGGYGVALASGQGHHYYCANEIPGVTDNIPLLGLGGKGGTRFQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6V8</accession>
    <name>A0AAE0U6V8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-Methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_11356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6V8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="825"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="98475" checksum="F0BAC35EAE62DC2A" modified="2024-05-29" version="1">MPSSKDRDVDVDDRSREKRHRPKTERKDRDRERDKDKDRDREKDRDRDKDSTTSTHRHRSSRSSKLRPTDSDTHSRSSHRRHRTKEMDKDDTGYRPPTASSMTDLVPELTRGIASDRGGVPYPSFSKAHSKEFLHSKDDVSSPGARRTDPLTPEATDLGGSEMRRSKSADSPDTSRKSSSTRKASRQEDRPPSPPETDLAAPKERSGTPVSVREVGQSDVRSGGSRNSSWVSGSTPKNESKSRLSKASSQATFIKPLTVESRVAESEAPTTASTVESSSAATSVPPKRSASGAPTRPPPIEVDSSPESAPDSSPKTPTQTPQFPPPGMADEKQHFRFGRPSDAPNPPPTPAHVGAPPAPPPPPPPPPPINIQDIPRVDYLMQNGGLPHQVPRTFLAALPRQNGTRPSNPPLQGAETLFAPFFNLLNQYQTVLSGHGSIAVATGHKTVARRLLDRLENVFSRDLSPDGCFCIMCEHSEDLHRGLGWGEVLERVSGRVDLPPWPPFDLASVGTKATEGLADVPARPASPVKMDPDIAEEFREHYLRQSKRVRAAVDNWMTKCDKSPAPPPEEVDDETLTFAILTNLEYEDRPYFNALISGSRELLPATRAPTPVRKSRNDFVVKSGLSIQRLYRLPQVPRDAETAMYLVKNPGMHDLLHTISEINQSEWEILISGRFDGFLWTGAEDDGIPLGEGPSRGATPASGIFPPPSRIMSPGMMAGGRAPLGGSRNPTPFSPYSRGPTPSSFISGVSAASSSYPSRAAVSHDEETEIAVVAELEREIFNGMEALEDAFERLHEQAIAVRDTLRRRGAALSMSLQQRRGLGGNRIDVLPLSGSSGAHDRPAWADEESMDGESEWGGDDVSELAPDDSASQISSNRLRRPKRRRERATPAPIEEEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7F8</accession>
    <name>A0AAE0U7F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_387925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7F8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="475"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="557" mass="60654" checksum="DF848189A77A4FDC" modified="2024-05-29" version="1">MSSRGEAAAAADLQQFMQVTDTDEAVARRALGIFSGNIEQALQVWFSDEAFQESLRQGGDDDAATRSPVGAQSSALSAGYVDAQGVIHLDSESESDVDMTGGDSDFDEEAEAAEEAASIARAAQEAEDAAMAARLQEELYGVAGAPVAGSHGGNDEVRAPMARTTETLVGPGGLLSDDGDDAAAAAMMHQIQQLRRRNGKFPITTTTATTTTPAGPSAGPEGPVTSRASHLADLFRPPYELMIREDWDEVRSLGKDEKKWILVNLQDASDFNCQVLNRDIWKDAEIKSLIRECFLFLQYEKSDLAAEQYISFYLPNMAHENPSNYPHVAIIDPRTGEQVKVWSGLPFPSAIDFYGQLVEFLDRYSLEANHKNPVSKAKRPERVVDVDRMTEDEMLQLAMQNSLENGGPSRPDVIDPDELTKATSTDVHSSTDKGKGRAVTPEELMDTEDTPAANPARAAFLAIPSDRPHVEPAANPASTTRLQVRFPPSRFIRRFNLDDPVSRIYEWLKAEPIPGKEGVLFELTTVPAGVNLLDLLTQSIKDAGLANGTVMIEFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7N3</accession>
    <name>A0AAE0U7N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_444254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="265" mass="28688" checksum="1C4254ECF3E0FF45" modified="2024-05-29" version="1">MPRILIVGATRGLGAALVYRYAKHDWSVYATARSSKPDTASFPPQTKWLKEVDCAKSDVGDTIARHAYLNPFDQSVNDPLDVAVITAGVFTTEDFNKRDEGGPNFDDEMRMYATSAVAPVLIVHALVHNGLLKTGSKVVLVSSEAGSVALRIEAEGNYGHHASKAALNMVGKLLSLELQDKGIVVSIVHPGFMRTQMTHGVGFDKFWDSGHAVTPDEAAVSLKEWTDELDMSKSGQFWAPRGPADIGTAENVLGKNLSTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7X2</accession>
    <name>A0AAE0U7X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_517430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="209" mass="22872" checksum="962929B4B05BCB65" modified="2024-05-29" version="1">MSNSNSNSSCTSSPPLPPPPTLQDAAQTGASSIIYLDLAIRTAGGIGASNPSPRPSDSLPPPPPPTTSSSSNMAPRRSNNKNNNDNNFVPEAVVGANSPQKPRLPKIVVRFDAYFGQGELADWQRLCHDLGIGGNLSSKTKCCKALEKVMVNIHDLLDAVEAEEQTLVRRFSNRHDLIEYTRRHHKFYPLKHAKEMGPVRALLRHLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U805</accession>
    <name>A0AAE0U805_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_459392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U805"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="529" mass="58290" checksum="7A00A78A93C38D1B" modified="2024-05-29" version="1">MSLFSAQLHPGRALGFLVLGASLHDILTRLKAEPLRFPKLDLLYSPPDPVREPIVLSLPANGVRLRFDGPEQRLRLVEVIDFTKNHIFLKPANDKERDLVRPPTTNQAGPSSQPSQPPEVAGPTFRHIYQRFLGPTYDGEYIPDAEDSKGAAGTYVLSYPGVAFTFPMRRSDYSPSKDVVSLLSSSAIPNSMAVFSGDSWSQSRETMWTELLPSIKLTAPVVKGKDVCPDEVSLVKIYGGGKLEFMRNWTNSSFWVMLGDTTPQQLVAELGPPNAIYRKNEQRMYIHKLRAASNTMARPSGIDLKQQDLDSTDTDQSSHAASDEYDSNEEGAIEDDVVANVSGECFYNYFYLGFDILVSTPAAPSRPPPSQNGNGGLPEVPFKAESADRLVATKVILHSNVPGSYPFNRHRRCRWEIPYLVPSSDSPPVNSETPFSEIEDGLREEWESIYASESEARKRQRGMVLNRGWGDSPGSSCELLGGWEESGGATPGVGRKLDGNEDSTTTLYGFPGLVFEVLKNGYVSAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8N9</accession>
    <name>A0AAE0U8N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_50524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8N9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001345">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="546" mass="60702" checksum="AD92B913C2F7FB70" modified="2024-05-29" version="1">MSMITTTAWVPRGFAAPFPTKYNFDEEEFERIAGLAKLQLDEAQEDLEKAQEEDLEKAQEEEAEKKSKKKSKKKAEKADEDSDIEIDEDLKEYDLEHYDDDDEDQANAQQMGMFGNVKSLAYYESNKDDPYITLKDVPDDEDEREDLQILATDNLLLAAKVEDELAHLEVYVYEDEADNLYVHHDIMLPAIPLCVEWLNIPVGKAGVEKDSVANFVAIGTFDPDIEIWDLDMVDCMYPNAILGLGGSEEEKKKKKRKKSKKANDEYHVDAVLALAANRTHRNLLASASADKTVKLWDLHTTKCAKSYTYHTDKVCSLAWHPVEATVLLSGSYDRTAAIADMRAPTEAPTRVGVESDVENVRWDPHDPNYFFVSTENGHIHYFDVRSASKDPAASKAAWTLQAHDESISSFDLNPVVPGFMATGSTDKTIKLWNITATGPSLVVSRDFDVGKVFSTTFGPDKEVAFRLAVAGSKGTVSVWDTSTNAGVRKAFAQKLPTNAAKYGEVEDRLVGVDDAGESSSSEEEGGEEDEEEDDDEDGAVVSMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8T7</accession>
    <name>A0AAE0U8T7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8T7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36611" checksum="2AD7D740484B6F04" modified="2024-05-29" version="1">MVSHTEIQASNALINDATAPRTAVFVGGTAGIGQLTIRALVATDASVRIFIIGRKSAEERMNVFIQELRTTNPKAEIIWIEAEVSLLAETKRVCAVIKGKEAHVDLLFLTTGYAPFGGRKETTEGVEIAQSLEHYTRVLFILHLLPLLEKAEAPRVVSVLSGGMEMANIDLDDIDLKRPGNFNVMKAQTQYMALHTMVLEKLADQNPNVAFIHSWPGWVNTGNVKRGRDPNSFLSWLIWFTLEPLIWLFATSDDVSAQMHLFQCTSAAFGGRGIPWNGKPGVTSLGKETDGLFLVNKNCDCTPNAKVLAKLREEAQGKIWDHTQDVLRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYJ0</accession>
    <name>A0AAE0JYJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="50"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="35099" checksum="1E73751CCA0CD1C3" modified="2024-05-29" version="1">MSLQGFAFLLSPSLPVPSELLTNKTYIFSLRPTDIIRTNAVLGLVPFVSALVSGLAPPNYPGFRTLWSDSFDGSAGQLPNAGQWSLVTNIHVNNEMQEYTTSNQNVQISGGGTIQFVPRKTNGKWTSGRIESKQAFTTEAGKVTMVESVIRFSDNSRDRKQGIWPAFWMLGEAVRHGTPWPLCGEIDIMETVNGLPTGYGTVHCGYSDKGGPCNEPQGRAGTTGLPDSGWHRWTIKIDRTRSYNWRDEVIFWYLDGQQYYALSGGDLGDEHIWTTIARSPMFIILNLAVGGNWPGAPNGATADSWGSMMEVEYVAVYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYR0</accession>
    <name>A0AAE0JYR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydroorotate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_498190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYR0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="366"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3366502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="645" mass="70535" checksum="184247832BBA50C4" modified="2024-05-29" version="1">MATSSLYRAVFRRRVQQFRQWQRRPLSTNKAEPSSPKTNSDLKNVGAESQIPTPNNAYGRAQRKRPLTTQLCSSLVIYFCSDISAQYMGKREYDLVRTGRSLIIGAISSMPSYKWFVWLSISFNYPSRLLSLATKVIVNQLWFTPIFNTYFFGMQALLAGENLGEIWTRIKRTVPTSFLNSCKLWPAVTAFSFTFIPLEYRSLFAGVIAVGWQTYLSFLNRQAEEEGGKQLPLPDMAAPYLRARPPLSSAVRPLTTTRIAARAAPRRLASTSSSPASESLLLARLKTVLLSGLGTVSLYATYYYVTDTRASVHRWIVPPLLRAVYPDAEDAHHAGTTSLKNLYAVNLHPRERLSQSDAETPGNPLSIYVFGTELANPIGISAGLDKDADVPDALFALGAAVVEVGGCTPLPQAGNPRPRVFRVPSIDGMINRYGLNSRGADAMAARLRDRLRKFARTLVQIAKNKGTDEKDVNAVIHDYVYCVNRLAPYADVLVVNVSSPNTPGLRDLQSIEPLTKLLSAVVDEANRTDRKRKPKVMVKMEGVVQAVWTSGVDGVIVGNTTKRRTGLVPQGSSSGESGEGAGTGTLPAHKVIFATGGITNGKQALQVLNAGASVAQVYTGLTYGGPGTITRIKGEMREQLSVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0K5</accession>
    <name>A0AAE0K0K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_87181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0K5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="101" mass="10874" checksum="9C569413ED48211A" modified="2024-05-29" version="1">MTMPAIVAAVVLVPVNGADTRILRNFTQGGPRPRQEDASSPPSVHHHEDLALHSVLPGYCCSTLSCRKMRGCGRGADPKLSRSTRPITTADKRFNTCSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0Q7</accession>
    <name>A0AAE0K0Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0Q7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="11187" checksum="0E8A20DA7B765469" modified="2024-05-29" version="1">MYTKTIIIYRDGVSEGQYQHVINDEYAHFKNVCESVYTKVKKSPPKIAIIVTTTPAPAGTVVHRGVTNQFMWDFYLQARKAIKGTARPAHYAFVMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0R6</accession>
    <name>A0AAE0K0R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_536003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0R6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="528" mass="57928" checksum="C2D41DE5506201E1" modified="2024-05-29" version="1">MMVYNGPSKGCKTCRIRRVKCDQARPGCVNCCRRNELCPGYSDVFEKMHRDETFRVLKRNSQRKAQASPTADDASLRIASTVLPGLEFTALGFFFHHYGGVNANRDIQATCSFFEFLPAMYARASVSSPLSIAITAFAINVANLHSFRRSNATAACRLYVDAVAGTKIAIADPRRSKSDELLMATLVLEAYESVNASFQRRQKSHAHALGSIALLRHRGALANRNELSRRMTIAVGSRFIRDAVDGMANIITVRRLWEDAGVTKSHSPAIRADILALELAQLECLQRSLSISPSGSALDAVVEADPYLSILSKASDLASRCMQWRVTLPCKWRFSPMPIYELAPSIQTAGMYSSPTSTNPHCDIYNNLSVANTLNRHRITELRNLALIRTSLAAVSTQLDCYERLSPLESGRRAQFLVDEICASVPFFAGDVTGSTILHAKDGIQVPYISPPASSPASTETLVAFPEDNAGYARQVVTSGLWMIHDTLVAALNIVAENGALGAVLRKGQVLWIRGQISRLQAVFRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0T4</accession>
    <name>A0AAE0K0T4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_515401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042016290" description="CPAF-like PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="105"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="450" mass="49324" checksum="534136BA164F320A" modified="2024-05-29" version="1">MLPAVQILAVALALSQLSDGLPASDKIATTESHSTLDYLKNPSRGYLSESVDLIRGLDDIAANLKNSSVYSNKFAFLADLYTLTGIRVRDAHFSYTSLLFDLFTFRIGVKFISISDEGLSLHRIVLHDDTNHTQLGYVPSPVSTINGIPALEYLQKISPHSGGSHDPDTRFNMLFPSVVKESAYTQSDRNFATTFPGYPKPVNVTLAGSTAGFIPSFSDDVAVLAVNSFVEVVNPKNLAPILDTTLHIHNVTVDFLSHAKQTGRTKLILDLQSNGGGLLPNLAALYLTLFPAETQLHLLWKVRAYPQLEWLGKELMPTKNQTTTASYSLPSALKPFTQPNYTAWPSFPPFYGPVPEGAKWGSYTHPSLLNPLTRIHIPGLSHLALPASGHHPPLGRTVRLRMRAVRIHPHARARDPHCSHGRPAARVAADASRRTGQREAGDFLWDVSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K160</accession>
    <name>A0AAE0K160_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_82178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K160"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042048751" description="chitinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="43846" checksum="F32C41FD948F9CDA" modified="2024-05-29" version="1">MRLRWSTAFWWLSYGMATEVALGATPPRCIMYLTGQHPVVPPIEQVRHVTHVALAFMRPGAFTVPGQTEWPLFTSVNEVRRKFPAKTKIMIAIGGWGDTKGFIGGAKTDQTRKAFAREVAKMVMATGADGIDIDWEYPGGNGEDYKVVPNSKKAWEIEAYPLLLSELRAALGPDKVISAAVPGLERDMLAFTRLTVPRIMRHLDFLNVMTYDLMNRRDNVTKHHTGVYLSLKAVDAYVAAGAAPQNINLGFAFYTKYFKTEHETCKRLASPVGCPTLLLEDPETGGDLGRGGGFSWHDPVPKEVAGSFTRALNLGTYDENQGGYYYWDKDEDIWWTFDTPDAIKRKFPLVVNKKRLGGVFAWGLGEDAPMYEHLGAMNEALDERTKETKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K190</accession>
    <name>A0AAE0K190_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K190"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="803" mass="87386" checksum="38F97D6CAAC03ECB" modified="2024-05-29" version="1">MSQMLVPYNNAMRLGQGFNSYTQQICLDHAVLECEPPKQAHLHPKPKFNQNLGNDGDSAALINSPSDDGSHDDKSTSTKHGDALSVAAKPEIVTYSSRFVDKLSDVTDSMNVSGSLSIKTATIGGKANGSYIDSDEFKSSDINLHLQVKATNQVLEADEHCIFNKIAGVEAHQFPEVYGVVPLAIAGNALDCFISGSLTSRPGLEGELSTPTLSGKVEAEFSLNSSKLTKETETTINVYWSGGGSIKDPTKDWTITTLKAAAAAFPERVAVMPQRMYSLASVQPLPKNQTDAKKFNPNPVARAAITTTDSDGTKRQAVAVQDEGNNSVGGNNDEQPPKPTQFPIFSPTFAGLIQARKVCRFEMAKIVNEVDLVAKDPKLSTDMRRDAYFLHPLVFEQLLPDPNAALLLGYVAPVEEPDALLPVFLLESPIENHDLKLQRLIQKVAWKAPDYILQGCAGVRLEREVRSQATLINDLEDLDGTFRPSQIAVWSVDHVVHGLKITYAKGSQKTHGTCDGAASHTWTLGPDGSEIIDEPEEEKEEEKETTTTASGTPPTIIKTHNWTRPEDDAQWSLRGFFTFTHASGSTPQTTNEKPIPVLTTLGVVWGKDTFAPLPSASLSSPICKSFLGLSPLLQSSIHKFKALDNYKGYADKFLLGKSVSATSATSSSPANPDDVPDVKIKCFNVLDDIDIHWTLRSIAFASKNGKLAGLRVTYANGQVRTHGTFENEAWKCEVGPQMPLIVAKLIAGKTNDKGEGFVNTVEFIRGEAETLRQPAWPLDVSTLRYLGEAGSTREDYVFVALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K222</accession>
    <name>A0AAE0K222_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K222"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24082" checksum="8B4BF30CCDB33159" modified="2024-05-29" version="1">MARPARGGGRATPAAAATDSITAATASYSLRSSAPSSAVRKCEWCSKSLSIAQFNTALSRSQGVGPKVCHGCITGTLKHTRRAHKTTVRAERKQQQENKINPKSNSKDVKSSALSQDKKSNTREEEVEHSSTGKSAKKTVSGYDFPHDTTPDKESGLGPANLTKGGETAPRPSLMDRIPEQDRNPSAEEGENAYAFVDRWMDAVEAAKPELGSEWEPGLEPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K223</accession>
    <name>A0AAE0K223_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_77770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1477" mass="165670" checksum="89510D755C01FF38" modified="2024-05-29" version="1">MDLTAAAYLIFLLPIALLYNQVTKRVPAQAIYLVVFLFLIAFIYNQATKKIPSRLDPDQAPKSRFELVPAAANGLPTRADGFDIIFVHGLGSNPDTTWRATKPAAVADTPEEAGTDSERFVNWVSDFLPGDILPASKDVRIFFYNYDSYWKRDAVNTRLTNLGNELLEHINGEIRISETERSRNLIFVAHSFGGLVVKRALVQAQASREFSHVAEHTKAILFLGTPHRGSSFGPLGWLAAQALQPLGSNPLLLANLEYDSISLHDLHKDFIRTSQDDLRVFNFFEKRPTQILQLWFVQWQRLCVREQSATYEGRDVRNIGLSVDHYGLNKFASKSESYKTILSKLIDVTRSSAWPAKHYYAVPLETVHTYTERAELSTELKRKLQIRHEKASVPYAIVLHGLGGAGKSQLALDYAEKHRDQYNPILWIDAKDEEAVRSSFIRCATELGIRVDRIEKQGSVLTDPAVLAVIQWLRGRIEEDDKWLVIVDNADDVSWGIQKIIPKGNRGNIIITSQDSRSIKLIPGGCERVRVGLMSPLEGAGLLFQHLRLDPKSASKGIKRGCDEISNRLGYLALAIDLAGAHIAENSPAEQALWQYLADYDRHRDELLQMDSFRGLRPTEKTVWTVWDTTLEKITKEYLRFRPDLLLTFLAHFKGSIIQDEMFHLASLGMAAVNVGLGKEVGDKMPAELQQYFSLGEDGWDSFGYRQGCDILLRYNLLQRVEGKWAGVTMHSLVQWRARQSYRSQPWLWWNTVFVLAVCCQVEQQREKPEFRRHLIVHLPDIGESFVGGKDYDSFIGAKLGRIYYDEGRWEEAEGLFVQVMETSKTKLGADHPSTLTSMANLASTYRNQGRWEEAEGLDVQVMEMSKTKLGADHPSTLTSMANLASTYKNQGRWEEAEGLFVQVMETSKTKLGADHPSTLTSMANLASTFWNQGRWEEAEGLEVQVMEMSKTKLGADHPSTLTSMANLASTFWNQGRWEEAEGLFVQVMEMSKTKLGADHPSTLTSMANLASTYRNQGRWEEAEGLEVQVMEMSKTKLGADHPSTLTSMANLASTFWNQGRWEEAEGLFVQVMETSKTKLGADHPDTLTSMANLASTYRNQGRWEEAEGLDVQVMEMSKTKLGADHPDTLTSMANLASTFWNQGRWEEAEGLEVQVMEMSKTKLGADHPSTLTSMANLASTYKNQGRWEEAEGLFVQVMETRKTKLGADHPSTLTSMANLASTYRNQGRWEEAEGLEVQVIETSKTKLGADHPSTLTSMANLASTFWNQGRWEEAEGLFVQVMEMSKTKLGADHPSTLTSMANLASTYKNQGRWEEAEGLEVQVMEMSKTKLGADHPSTLTSMANLASTYRNQGRWEEAEGLFVQVMEMSKTKLGADHPSTLTSMANLASTFWNQGRWEEAEGLEVQVMEMSKTKLGADHPSTLTSMANLAITWKDQGRLADALALLEDCAQAQQRVLGQKHSNTLSSLATIAKWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K298</accession>
    <name>A0AAE0K298_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_534430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K298"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="245" mass="27125" checksum="724F8B29369E5FC5" modified="2024-05-29" version="1">MASPLVNDQTLGTLYYSGTFINPAPKIMGACAPGTVLGITRDHIRLSSQLRSLFLPEDIILFKYRKYPQALLDPYSTHGTPPTPPDRRVPRTSIAEQIGSGGVFLASFRCMSSALLAWRLASTASAAAWSFIALATVGTISAAAYMHLNPSRAATHLANGLLPSHSDWFFHKWCSPLRYRHHVHHSLDARPRTAVNGNSQPCQRITNQARGLENGHVLVAIAPYPDLFTCPGFRWLNKLYLQYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K569</accession>
    <name>A0AAE0K569_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_514481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K569"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="11999" checksum="C28099F5DFCEC626" modified="2024-05-29" version="1">MAPVFILPYPPFVPAEYSFTAEDIVALWTGGHTAIVVGLILIGIFGGSVELEHFYDDYADMFSIKPRPKFDEDARSISSDVIRLLAVSETTPLLPPKTPVASTPTRTACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5I5</accession>
    <name>A0AAE0K5I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_316309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5I5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3370464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="59277" checksum="02C7F89ED7E0AB50" modified="2024-05-29" version="1">MVAPLTTQAAPLPPAAHRNGLLVEKRIVIICFIIAFGQFQYGYDSAAIAGFQAMPGFLQVYGYYDPKIGYNISTDVQRLIQSLMNVGGFLSAIIIYSMGSRLSRRLGLWMGCFFGILSVSIMIGLTSLASLYAGRLLLGMSNGFFVPYSMMFMTESAPALLRGSIVGMVTFQTSLGALFGILVDNYTVRYEGNASWQIPLGVMYIVPTLLAIFLVFLPDTPRYYVAKGQDEKALWAIRRLRGIEDDALLRAEVEDIKSAYLLEEQLHSGVHLRDMFRGTDLRRTLLCYATTVGGTATGVTFMAGFSVYLFVQAKVGSAFVWVMISLAIALSGNMAAFPAMRLFGRRELLIYTSIVSSAMWFGMAIGYTIAPGAPPAAKALVAFSIVFTWIYGIGQGPVMWALSVEIPSQRLRSQTVGTATGINFVFGWLTAFFSPYFINPDKLNWGPRYGYIWGASNLILAIFTFFVIPETKGRSLEQLDELFEKRVAARKFSKFVVERQLVEDVLAGDLRREELERKGAVVQVEGDVEKNGHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5K1</accession>
    <name>A0AAE0K5K1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5K1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042283755" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15165" checksum="E24CA33CAF60A5B8" modified="2024-05-29" version="1">MHGCFCLLPMLAMLLSVPMLCVVALDPPESCLALCTAVSLTLASQLVSSPESRPNSQLLLRSTQCVGEGFQRHLLVSAWKLRLFWRVLDWLSPLGSGNWKKTRAAFVRLLGEPGARQLMRRRKMAQGSLATTAMLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5K7</accession>
    <name>A0AAE0K5K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_403071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5K7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="199" mass="21703" checksum="42C6D13C47499E18" modified="2024-05-29" version="1">MNTMATSTSVGALPEPPRASPAAHAHHNRDLALQKYLLLHEQHESLRQHLDELRPLPPSRDMAAPTATAISPVGSPTRNGSVASFSSSSGQASPYHSRSSSLCGPFRRSSLPSRIMMCNGSSTGSELETVPDETTLAEVAIEEAKLCDVNEGIKRALTELLNCEAVRGDRAFRTWVQCRLMDTERELRSGRRRRSAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6W6</accession>
    <name>A0AAE0K6W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_552440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6W6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="571" mass="62375" checksum="70B484B20A2918DD" modified="2024-05-29" version="1">MVQAAPPATDTSSAEPEINAAQVILSLWLAPIIEAVVLLNKDNFTALATLRAPSFVPGPELRGTTSILWSCIVTLTACLYTALHLNVPTRRGPLRTLLYKGKWVLFGLIAPEIVLYLAISQFLEARNLAKQLTLLWKKKNTVKTGDKNASISTKADGHDKDGTEHKCDLKYAFFVVMGGMEVSVRDIEPKHNPKAARGTPRSGRLRATTKGILQLAKDGHFLPLSRSKISDKSKADVLQKLLVMVQIVWMATQCIARKVYGLPLALLEVHTMIHVLCAVVLLGFWVDKPKDVGDPELLDISEFEDLVALMYQESLESGRLDDVREFMDVVEAHGKIQWPNYPVLCPIALDGDGGEDEVTLIPSEDASSVSESNEDANQVQAPGEEATPNQDTINNNPAQAPSEGANLTQDTIDNNAAPVIDVSSAAAVSLYPGQTFSFGIGVDTSTASNSSEEEQGLEAVSFTEPDILRWKRIRAAVERIDGCGSVLVKQPFWPTEDGPRYSHCSYHESLGPDGGHNTSYFGARMQPVELITFILEHKLLLLLVLVLSTAYGGVQLAFIGFDFPTRFELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8F7</accession>
    <name>A0AAE0K8F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_439059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3371976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="310" mass="34073" checksum="FBCBEDFDA64171C4" modified="2024-05-29" version="1">MAAKSFKLNTGADIPALGLGTWQSETGKVKEAVACALKSGYRLIDGAYCYGNEDEVGEGLAEAFASGAVKREDVFVVSKVWTTYNTRVELGLDKSLKSLGLDYVDLFLVHWPLLMNPDGDHDKFPKLPSGERDIIRDYNHVDTWKQMEKLVATGKTKAIGVSNYSKRYLEQLLPHATIVPAVNQIENHPELPQQEIVDLCREKGIHIMAYSPLGSTGGPLLTAEPVVKVAEKHGVKPSTVLLSYHVARGSTVLAKSVSPERIRANLEIINLDSEDKKTLDDYSSSLAAEGKLHRYVYPPFGVDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K912</accession>
    <name>A0AAE0K912_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_439430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K912"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="5">
        <location>
            <begin position="132"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="632" mass="70020" checksum="8725DDF589B5E14C" modified="2024-05-29" version="1">MAQIPEPGSPLIPHVLKTDVDDILDDIDGHIHGPISRLTTKYFSKFDSILRDDVAHIMGVASLDGGCSVSPPFSSAQDFSHRSSAFSSRDLNGARGTWSTCCHPSALDSASVHLPEGAASHLFLSRSAAPFDPKTESSWRDVQVIGQFCQQGGRVISYRDGLLNLCAHAREVFANQTTRLFLHGFYLCGSLLELWVFDRSGIYGSDVVDIEKDLSKFLSIMLSYPLMSDGELGRSDIIRNDDIGSFVTLEDAPTIPLGKLYLEGQPIALSENLVGEGTTCFRAKALGSDEWTHVIKFKWRWAATRPEGTLLRLAKEKGVWGVASLDYHREFTRTAELRSGLGWRKSDRGCEETLQDQQKQPVSPKSATATGPGGLLDITEETNQFLKNRILTCLVISPAGRPLRTFKSVLELLHVFRDAIKAHRSLLQDANILHQDFSAQNIIIITEPLSDHDDPKGMLIDLDVAMDLSVGPRTPGELVGTRIFMAIGILQGRPHTYRHDLESFFYVFLWTIIINRSDHLPSDSKLRPSSPTTTTWGEVAAQKENLMGGKETFAEILAEFTPEFGSLKPLAETLRQILLFPVGIDGEIIWTGTDGTPEAVNRLYDEMIGAFEDAIAEMKRRRNYLEPGHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K951</accession>
    <name>A0AAE0K951_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_483332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-cis-phytoene + A = all-trans-phytofluene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30603"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>all-trans-neurosporene + A = all-trans-lycopene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30623"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30624"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-phytofluene + A = all-trans-zeta-carotene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30607"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-zeta-carotene + A = all-trans-neurosporene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30611"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:30612"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K951"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3371935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="43642" checksum="C068ED09569E3D12" modified="2024-05-29" version="1">MARSKETAAPRSAIVVGAGTGGIAIAARLAKAGLAVTVLEKNDFTGGRCSIIRTEAGFRFDQGPSLLLLPNLFREAFADLDTTMEDEGIELLQCMPNYDIWFADGDVFRSSTDTAAMKREIERFEGPDGFQRYMAWMAEAHGHYELSMKHVLHSNFTTYAQLAMPRFVAAGLSLHPLENIYSRISRYFWTDRLRRVFTFATMYMGMSPYEAPSTYSLLQYTELAEGIWYPKGGFQQVLAALEGVGRRMGVDFRLGSPVAKILTTGNPDGKTATGVELASGETLEADIVVVNADLVYAYSNLFPQESEEISGYAKDLRARDASCSSISLYWSLKKKVPELGTHNIFLADEYKESFDAIFKRQSLPDDPSFVSLSCHFCVFGWVSSRLDIRQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9C2</accession>
    <name>A0AAE0K9C2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_513741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9C2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="242" mass="26367" checksum="6366342F5A644A9F" modified="2024-05-29" version="1">MGAAASAIANALDNSKEKEAQAKEQLELMMKLADARLDTFEAELREMFLDKDSAQKFSVPGKRALRFERHVKVDTETSPGKGVDEAVDAFFGASKTGTDGVLEGFKAVVKTGMSAILGDTSAGESYDKKFFVCIKHNAIIRVDMYTYKYNFRNSGVVDNAKNILAYILCISVVDHRDVTVDELVYLASEFAGDGNVGPNSGYELYLDSLMKTWNALSVVEVPGLNPGRKGIEYPALQIRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA81</accession>
    <name>A0AAE0KA81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_563730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="25702" checksum="C67C018653117B78" modified="2024-05-29" version="1">MSEQEPPMAMQLSAHQVLSLTKDERVLFVKQNLRRTQDGALDIRNIDGLEDLSEAWRPLLGEELIQAEFRVWQLRNRHRRPAFDEYPEEHRRDFLMHGEIPKSAAKPDFEQAARRLWEREYDYGQQSQQQLDGDGDGDGIRVIALSRHSEKVGKRLADRGFAQPSFQLLADPKRQDQWTTYVEYLAFESSSLRKLDITAQRLQEWAKEQTDGHEDAVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEH7</accession>
    <name>A0AAE0KEH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">B0H63DRAFT_438060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEH7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="331"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="891"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1272" mass="140473" checksum="D42849F8382424A6" modified="2024-05-29" version="1">MAEASSTTSGGGNAAPEGNPPPPKTDALDGQQSMEDESEQVEDTPFAITVVLPHDSKSFEIPVSPLEQIHEIRQSIIEHPLAIQYSCFHLEHKGKRINDFAQVSDVEGLASNSELHVVEDPYTEKEARIHLIRVRELIGAAGDRTDTIQGILAGVSVYDDIPNGKDTSNEKNGDDTAQVDEYDFSAPPSLSTLLPQELEPKPQTVRSISLSPWNPPPAPLRQKGHLLYLQISTNENEQFHITAHVGGFFVNKSSNAKFDPFPKGGPKAEAAHSLFTLLLKISPSFEAKFGDYQDYCNRKDPLATFQIGNAFPSAPWIVPSSASTLCTHSADLTRTQETFLLGGAENTDSLRDWNEEFQSAKELPRDTIQDRVFRERLLSKLYADYNDAATRGAVLVARGEVAPLNPTEGRDAQIFVYNNVFFSFGTDGVGTFTSEGGDEAARVATGKDVLGVKLVNQLDIDSLYTPGTVVVDYLGKRIVGQSIVPGIFKQPEPGENQIHYGAVDGKDVVAADERFAASFEKLAQALRVKKHSVWDKDNKRFDLEASVEMKGLLGTDGRKYVLDLYRITPLDIAWMEESSPEGADYPHRMTVLRPELIETMGKQKARDFLNTEMRRRKDAADAAESKTEAKNDGAKAKDDKKPDASLGEGVEETAELDRIDMSGFNFSLNPDVFSGQEPQTDAEKAEMAKDEDDVREACAYLRETIIPGLLRDLEESDISFPMDGRSLTRLLHRRGINMRYLGLLATLGAGTRADCLTKLCVREMIARSFKHVAAKYLKYLPLSLTSACFSHLFNCLLGAGVNPNPSADIDESLKALFSDTDLAFEQVTPESLRADIQKETLRRYRYALAEDWSSKLMHLQLLRDISLKLGLQLQLKNFVFTAEDQAAQSAKLATTTSNGNAPAESTKKNKKKKARDASPASVTSTTSSRAPHTFSPDDFVNVVPLIKDSCPRSALAEEALEAGRLSIYQNQRKLGEDLLLESLSLHEQIYGLVHPEVAQMYHTLSQLYYQLDQKDAAIELARKAAIVSERTVGLDSAETVLNYLNLSLFLHQRGASQLALAYAKHALDLWKIIYGPDHPDTITTMNNYAVMLQSIKAYHESRRWFEESLRVCETVFGKNTVNSATLLFQLAQALALDQDPKGAMNRMRESYSIFKNTLGDDDKNTQEANHWLEQLTANAVSLAKHARDVELRKSKPSNFRLSSTSTGTGKQAEPKPASETPVNAVTPRDTRSIESLLHWIEAGEQKQGASGSRSNKKNAGRGNPKRRGGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KES9</accession>
    <name>A0AAE0KES9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_562705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KES9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72055" checksum="9226FAE15C80674D" modified="2024-05-29" version="1">MSRFNHNHQYDYGYGPVWGDAGTFHGDVASAVLTSPPRRSGTGYSDRDDRAAARKAPSSREREREGERERERDRERDRDRDRDRERDWIVVDREKDNLKQRLKNRTNATTSPPSHVVPRHNNANHSRARSLSLSRITSSSSSLSERERDRDRDYYRDDDDSPTRSQNHRPMVKYYQNERFSVSSPRVPLAPSAGWPLSSPAPRTVTTRESPNFGPRYPPDHHRGFLAEQARHMQTRSADPLPHLSSRDDIRYGMQRMALVDPRMPSNRSASYDTPERNDGRGVVVRRKGVSMSPGRGVISPAPYHNVRNYNQVHVLIITWSFHDLKTAPYTAVPDADYISLEDETKRLRDTLHSYGYKVHEYEIPMVRAVESLRSKIKQFCRYAADDTLLMIYYHGHGALDDDNELVFSSHEHPDDPNWSQNAAAELYAALMSGDACPSHGRHNQFKQLIKKYERYRPVSDVRWEDIRATVLGAPCDLLLILDCCAAGGANLGHVNWQPPPSAENYTKHLFAACGFESSTSDDMTAVLCDVLDEWVPEPPIPQKQGGRGPSPAAPGAPFLTTKRLHQIMEDKLQKDSSGSQPIFKQLLPLDPERYIALPNLLERERATREREAWGVAGDYAAHARGRRGYIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFF7</accession>
    <name>A0AAE0KFF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_526291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="37915" checksum="5FB775B8ACC7BD72" modified="2024-05-29" version="1">MGINQSNPTCAVNSCLNQVIGYVDSIGFAQYNACRATYGAAQVEVMTLGDLYIDDNGRRFNYRCCGRISTSVETVYETLTSYSQVLETATEYTTTSVLTTFATVTAAPAPTVNKLLGQHIRHHNLATTTSPPPVPLASNCPILEEYSLACSCIYAASDATVTETAVIPSTVEWVTETSTAIPPTSTSILVNTVTVTVPVAATTTLTSTSTGTLTTATSTTTNAATPATPSPRYLVVNNGRRANRYLTSSGGILRISLVSTTASGAQPVSIPADGASPAQLTVPGSSPLVALYAIGGDIISNMYPETGAAATANGHITTTCRSASGVVSCGAPGAGLNFVFDCGSIGLFFGSTNPAPSSCISFTFRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KG20</accession>
    <name>A0AAE0KG20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_496654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KG20"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="305" mass="32524" checksum="F5F1B7FD0DB5AC20" modified="2024-05-29" version="1">MLHPTSLRRAAGMLTSSLPRVVAAARRSYSSSPPSSSAGEPFTDPTKYEFLQVTSPRPGVAQVTLHRPRALNALSTPLITELNASLTHINASPSIGCVVLTGSEKAFAAGADIKEMAPLTFSQAYTTSFIESWSQLTSTLKKPLIAAVSGHALGGGCELALMADVLYCTASANFGQPEIKLGTIPGAGGSQRLTRAIGKSRAMELILTGRFFSGDEAERWGVAARSFPTHEALMEGALATAETIAGYSRVAVMAAKEVVNKSQDLALRDGVEYERRVFHSLFGSHDQKIGMKAFAEKKNPEWSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJM4</accession>
    <name>A0AAE0KJM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_231639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJM4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="59385" checksum="C170A2BCF732C672" modified="2024-05-29" version="1">MDMGVNSSSDASGMLLSPSQGSRHMSLLVGVGFCLLLASWHFMFKPSAGDGATKEPPVSSTSLPIFGHLLGFYRHNIGYLEILRRQTRWPAYTIQILNLKTYVVTTPALSHVALRSRMLSLEPLSAMVVTRMLGLSKEANGILGLDKRGNWVGSPVLSERRVEFSRLLAPGPSLTGPSEIASNTVAAAVNAFGTEWEKQDLFRWLRDVITSGTVMGLYGPKNPVALDPTLIEDIWIFDENQLAMTWGFLQSWIAPAGVRAVKRISDAFEAYVREGRYELASEAVKSTIAATRKLGLCDNDYARLEVFNISVATVNTVPTAVSMIYNILANPKLLAAVRDELQGVLTTLPVDGKTHGRKKQELDLSAADKTCPLLIACYQEALRIGSTPTCNRAVLNDTVLTDPETGHQIKVNKGQRVSIPTFMLHSRDQIWGGDATVFDPWRFLPGGSAADSKGRAREQGFVPYGGGVHLCPGRHLAKLEILASGALMIMALEFSAEREGDNIVAPAYAGGFIGEANDKKTLASKFVRIRRREGLEDVEWSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKB3</accession>
    <name>A0AAE0KKB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_244928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKB3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="253" mass="28224" checksum="E6B51C76D3FB5963" modified="2024-05-29" version="1">MRSNEGCQLAVMKPGELLEGETHLLHTYRHLSPEERWFQLWDQLFTGWSRPTSAFVKDGINEVIDLLSREGEQLIQNWGRFHRYPPALRYPPSEPIVASPAPPKGSDELGQNIAVTDSGYGPRGSSGKEAQEKLPRIPQIQEFSGAATEENLDDTASDKPDAQSTRDESLLQSVLAFVDELYGSLPLGFDRVEFQNASPALGELLRAFAPKAKVRAFEICHILSIDTAVLWYNNRQSSRKVPRGFFRAAGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKF2</accession>
    <name>A0AAE0KKF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_237941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKF2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="13557" checksum="1A5C2299284B5A68" modified="2024-05-29" version="1">MDGICFLRARVLLFFRNTCLHFMFYFGWAEKGLVPVVQLDVLARRSIWGSGHRWQSYFNDAMLLLGGEPYMIDNMFSFSFITLSTRTLRIRYFGFFGDPYIGRSRFCALVWRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKS5</accession>
    <name>A0AAE0KKS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_223196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKS5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="706" mass="77284" checksum="4BBD89A646C01301" modified="2024-05-29" version="1">MEADAMPRTIGRRSAVLIGIDRYNSLFVEDLLGCSEDVRLVEDYLITLANISNITKLTAPAAPGPHGSSEDPPPTLKNVVSVLEKLAMDAQENDFIYIHYSGHGARLPTLFPSLKNGNLEDEVLVLVHESGQKVDSLRDVELAFLLNSITEKGAIVTIVLDCCHSAGAIRAGARSRGLNQIPPDALVARDPLHPESALQRSWKMQRRGSLRAASVMNHWMTASMGVEFLAACLSNQTAQEIQPENKTPRGLLTECLLDVLGGTSQHLDRGLTCEMVYNLVSRKVTAHKDSKRKQDVVFGGQRSRAFFGVGRISQAAVTITNITPQSNGEVYVELSAGYAHAVEKGDEFAFYPQDQTFTDITDYHSQLDVCKVTSVGDFVSQALVDVHGAADDTQGGSSLRFQVGCKAVQLQDILRRHVLSPRTVRVVVNDEGISSEEIQSIKNRIRTEGKAVELSDSSLPSSFFEVRVKRDNDFEISFIHNAETGIKETTRARSVDNLLLRLAHLAIYYNILSLPGSATARGLLVEKTGVLPAHFAPPPPQRCILDGSSPPPAVFGIEEIIPSEPQDITDGAALRVRVRNICYKPMNIEILDLEPSWKVSRIYPGDDQMPIVVHPNEAVDFFITMGIPAAVPDSVQSETFDSIIVLATTNEKTNFPIDILPHIHEISEGGSSPLDDNNSERPAKGVSSAQWYAERLNVRAVPRHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKX1</accession>
    <name>A0AAE0KKX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_547421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969935" evidence="7">
        <location>
            <begin position="34"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="35193" checksum="24A72D85195532C1" modified="2024-05-29" version="1">MQPLFVPAALLRCISLATIFLSLALSFTALVEAASKSPLMDRDFPDPSILQDTDGMWYAFATASGNKNIQVARAPAPAGPWQYIDQDMLPSTGSWTTGRNTWAPDVRLIAPGRYVMYYSGELGNNSALHCIGTATSSSVLGPYTPSSTPFACPVSQGGAIDPAGFYDSSTGRRYVVYKVDGNSIGHGGDCNNGIEPTVPTPVLLQEVSPSDGVTLLTDSAPVTILDRTAAADGPLVEAPDLLRAPDGTYVLFYSNHCWNSPAYSVNYATANSVTGPYTKSVRPLIGTGDGFNVTAPGGATSVSGAGSMVFHANCLQGRCLFHAQFSMNGVTVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLU2</accession>
    <name>A0AAE0KLU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_512636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13880" checksum="342D7F6EA33CC5FA" modified="2024-05-29" version="1">MSRSRLPIALGTVAAGGIGYYLYSAGGSPKVAEKKFESDAHRAAAAIKGELPHRGVGAESEGKKYGQEAGAKIDSAVATANRDISKAKSETEAYAKAAKADALKKIDEIDRKVEEGAAKSKSYISSWFGSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N089</accession>
    <name>A0AAE0N089_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_530018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000019">
        <property type="protein sequence ID" value="KAK3365445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N089"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="658"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3365445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="999" mass="112719" checksum="519C445AB60DA482" modified="2024-05-29" version="1">MFPTFTGNSRRARNVNLSGQRTTNPFTSTWAPATNVGASKTVAHAQAERQQRQHERDRLKAAQRIQKTWRGHRVRQGLKAARRQKLDQLYNTLDPELRIAQALPLLLAVYDAARPDDRPRLLWVAEDLLKSESDAASTPAQAQLLLDSLGAIMKIRPQAIEPVIGRYYRVLGRACHDIGPASQSPELVRGVVAPLLATQVPESFTKAAYHAFAHSFLTLHDLAFFESNVAALRNREPKTYESQADFLWLLAHLIALQDAKKQEVSSPLYLKALYLLLSMSSTYIRTAFRMPDPKGSSEARDMKISTLLEMFTMNHGAKSASEYDDASFLAGYILTLVYCFPTSGDDIRMRLYLADMSTQYGPLPALKFFWNATSRTSIFSTIASNGESTLDVLRQRPSGAGSSTAKEDSLWHREWRTILLFLELYVFILRLTDDDDFFSGLNPQSAVQGSPSRLRSSSLSMEELKRLTRFLKHLSFTLYYSATELLETAARTPLTLSSPVEFLASPSRRMDSADVDVASKTASFSITAGIEFEAFRTLVTAAMKMVYERDSRRPFLPKGHWLMTSNLDMGGFVEGVVNEDQRQREARESREEEDEDSDEIWTQMNQITLSLGKHETDMLRWKSGKHQNMQSVNVLARHQAKITRGHIFTDALTKFWDLDDGLKEPIQIQFVDEFGMEEAGIDGGGVTKEFLTSQAESLRAAQITENSETWNESMADLLRQYEFLGRIIGKCMYEGILIDIVFAGFFLLKWASARADNYRPSINDLHDLDEELYQGMLQLKNYPGDIKDLDLDFTINDQVSLPGAPVRTVTRNLVPNGDRIPVTNENRPLYISYVARHRLVVQSRAQTRAFLRGLGMIIDPTWLSMFNQSELQRLVGGDNSEIDVEDLRRHTVYGGVYVIGDDGEEHPTVKLFWDVLHSLDDAERRLVLKYVTSTPRAPLLGFSQLSPAFSIRDGGQEVDRLPSASTCMNLLKLPQYRTAESLREKLLYAVKSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1R3</accession>
    <name>A0AAE0N1R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="67955" checksum="DDDA5FB38478F234" modified="2024-05-29" version="1">MDPTTFERNGGATKDLSVLIGRFIVENNLFVHAVAVLKGTLDPREQRPLDDYVIEALERLEKRPDQLAHELERRYNDSPPPCSESSISCVTTELESCFGRSPSPPPPSEHQQWLLRKEAHTKAREIARSSGRPFPQFRNQAKRERERLEHQQSAAWPEGRKLMLPHDPTCDLKANAENNVRTRWVEQGIWGEDWGPAWPKGSTPEDPQFEKPEVAPFYNRPFPIFAEGWSKEHWSHEKCGPPPESVRRRVLTIWSWTPIVRDPEASRPYRQFQYQLEKEREWIKGKVEHEAPGGIVDLDALAYKSVKQNWIDDQIWDPNWTERPGSVWRHEEPDEPDDFDEEEPAVEAPAMSWPAVDVNGPNQPHSKAIDGHAPSGSFPPSAPALSPSQDVQPEAWRVRGSLFGSAAEAAWTTERLFQSAAEDADSQPSAPKARTPSSNAVVASTLVKASTERRPKRRRVNDEPPLDPIVTSALRSRPKRGRVDEPAEGNQLPPKRQRRKAPEDGSDIAIAEVRIVAVASSPRRSARISKQEKQPKPIVVAEPKPPTRRGRSKPLAKPSAATDTKATPAKRGRIDQSDLTAVPKRGRPKRVDHPDVTSKLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3J2</accession>
    <name>A0AAE0N3J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_514781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3J2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="53" mass="5804" checksum="E5A5A1345FF11DA3" modified="2024-05-29" version="1" fragment="single">DHDRTKAVSCAISLSKVQLYGLFFSILGGVSSFGDAQPLSRAKHITSLFLWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4S7</accession>
    <name>A0AAE0N4S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_310087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3370183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="366" mass="41409" checksum="8F19A44BD0DDFD62" modified="2024-05-29" version="1">MPRLPPSLFWQARQALSPLAAPLLRVCRDLPSTANELRWMREHIAVTPSLIPPKLRLWQFAERRARGEPLQYVLGTQPFGDLEIKCRPGVLIPRPETEAYTIELGRILLSSHTNNPKTKLITILDLCTGTGCIALQLFRQLQASATLLRVQGIDISPHAVSLARTNLSHNLNLNNLLVPRPPTEEANQSQTIRFTQADIFSPSFLTTQQQQQQQQQQQNQDQVDLDLLVSNPPYISQPGFARDTARSVRNHEPRLALVPELRGGSDDATQFNKGVLPEDIFYARLLDIAKTLRPKRVLLEVASMEQGSRVVDMLTQDDDTAKLYPHVEIWRDCPHAEFQRQTIGDREIRIRGSGEGRSVYLCRADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6T0</accession>
    <name>A0AAE0N6T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_293332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042283309" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="99" mass="10605" checksum="40F0F434676EC5D5" modified="2024-05-29" version="1">MTDGTGVLGLALVLWHMPGYDWCVVKFGYVSAFAELPTGMQAARSGNILPKLGGLGASRTELGDCWVVRTEEELGRVQGSDGVCDAKHKFAAGCNLFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7K6</accession>
    <name>A0AAE0N7K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_484552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7K6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48198" checksum="D88BF5FFC57E85EB" modified="2024-05-29" version="1">MAAPDSGPGEYRQYLPDLTSPRFTTMQKQDAHEYAKAFIEGGVPPWLHGLYLKWRQLFQEPFRGVTSDGRVRPDLFTLQDEGMPIEAIVAAADKLIDHLSQAQLQLVRYHIDAPEWRSWSNPEFLLSDKGIRLDELTTPVRDAVLAVLAVTLSPEGYAKAVGAMRINGFLGELVGAPAVCNEHSYNFVLFGEPSVSAPWGFSFYGHHLCLQVFLHKTQVVISPWFTGAEPNLVDEGTYAGTRILQDEETLGLALMQSLDPEKQTRAQIYKLLRDPAMPHGRWNHDDQRHLCGAYRDNRVVPYEGILVSEMSTKQQALVEAILGQYLLYLPAKARAIRLRQIKDFFHETYFCWIGGFADTDPFYYRLQSPVVIVEFDHHSGVFLTNQEPAKFHIHTLLRTPNGGDYGMALRPLIPGAEQAFVWEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8F4</accession>
    <name>A0AAE0N8F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_548881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8F4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73973" checksum="DEC877F5FB03296F" modified="2024-05-29" version="1">MNPEFSKAPVRVAVIGGGPSGLVTLRYLVTAHSFLGTAPIEAKLFESESAVGGVFHARTYEDAELVSSRQLTSFSDFRAREDDPDFLSAKRYVEYLNEYCSHFNLWPHIFLSTTVQSITRDSWGKHTVRYLVQATGEQLTWECDAIAVCSGLHVTPNVPQIAGIENIPMRIHSSEFKARSQFGVGKTVMVLGSGETGADVSYLAVTAPTKRVILCHSSGFHFAPKRNLNPIYLPILGSKPSKLTTVPLDNARASLFDTAYVHPLLRNSTALWTFYDAYVKGILWLTTGTPGGLGQYVGQPSPEKNHVSRIFFNKASNAAPYVSEPYRKTARKSLIERIRRSLIQLPIPDTHGREIDLAPWPDHVSKSGIVTFRNSGRPEWERMKNEIIKPDMVVFCTGYRQEFPFFRDHNKAVTVHDTSINASAIKPYPVASDADVRGVWHHDDPSVAFIGFMRPSLGAIPPISEMQAQLWIVHLLAPHLLPLFPLDPTHEPHYRLHHPKGSRINYGVDHESYVYQLALDMGSAMGACEIVSRALERRKARGGSGGGPLSGQEGASNGWWRLPLVWALGANINTKFRMRGPWWWRGAEEVMENEVWGAIKRRRWVFDHFLLSTLPMSIFGPLSLMVWIYATLYRFVFGVELGQSPRPVCCSTTVAKNLRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8W6</accession>
    <name>A0AAE0N8W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_400251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8W6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="687"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="918" mass="103426" checksum="6AE62338471E1AF7" modified="2024-05-29" version="1">MNGHDPDPDSDQAQVQQGPNEKLWKEIEDKYWDSVKTFREEEDRRIAEESQIDADEQKAKLEDALFNKFEDRKRLLKQLEKIDLEYQEIQESLDAVDQKLEADRAALLAERAKEDEAKRQMFRDYRPVKTLAKTSDEDADVVMTDKQSEPQQTNLKPQQTQPKPSEQTQPESQQTEPKPTEPRQPEPKQPEQQQPGQKQTEQKQNEKQPRTEQQRFMTTEQQRHGSAGRAAVKVVDSAGQLIGQLRPISLDNAWVRDVMQLPIQRVVEIRASRKFTPEMLETIYEPSDAKGAKWLSCYVQATGEIQSHACHTCAKNGGPFSTCVIIGGSEFPRCGNCEWNRQGCHGGTLHVRPRSRHSAAGETVTASLGKSPGRRAAAAAAEQTTISINTTATRGFTSSSSAGPKQLAAARKLLPGARKAAARPDSPALSTFMSETPEAETPSNPRGRPWKNLPEINKSVLLLRHDGIVFTEPEIVRGVPLAKISPGHPYWDPEWPSLQDYIQPQLQKWVDKYDEYVNNVAKPPPPSSKFLAGRQVNRGKAILRYLKEGELHPYQIVAKPYINKSLVSYDTLFRLVQVLEELAKFNTDVSPSQWLRQRLHEISVEQGDSFNLGKTVHDLYHDPKVTTLRSKSGFGNIGRPSGYRMATGDSGTPKKPARPLKRKEPHESPKTTPGSTAKRGTKNAAVQPAKPAQSTQPAQPAQPAQPTRPAQPAAIATQQAVAAKEPAPQIDTKKRRLSSASAANLVITADDLEYSGYTSQDSFSEDHVMRVDWRVYQVKHQKISTNTLVTQYWHWVGEGEGGAEENIFEHQVLKDVLPNKKVTWGVYKDPIDFHLRMSELTDITFAKDSLKIIISTKEIEGVTHRGNLLADFKRERTKRRFLAFMRKRGVKLVKTNGEYIQREWDRMDSDVLPHYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N935</accession>
    <name>A0AAE0N935_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_256319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N935"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042163482" evidence="10">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3374790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="401" mass="41753" checksum="8DA0AAD3A8FA2D55" modified="2024-05-29" version="1">MRLFSSLAAVGVLAAGASAENYLGFNSGSTLDTRAAKFKADFTAEFTTAQKLAGAPGVFNAVRLYTNIQAYSVDDPIEAFEAAIDTKTKILLGIWTSGTDSIDKEISALLKAVTKFGSKFTDLVIGMSIGSEDLYRISVTGIANKAGVGASPDQIIKFINTYKKAVANTALSKVPIGHVDTWDSWTNATNKAVIDAIDWVGVDEYPYYENGKGNDIKNSGTLFDKAFDATVASVGGKPVWVTETGWPASGPNWDLAVASTSNAEYYWQEVGCRKLFNKVPTFWYNLRDSNPDNTMKFAIAKDLKGGEPKFNLTCPTTFDTPSGTTSGSATSSTGVAASSSSSATTSTSTTNTGTTGAGAQSGTTTTSGTPAAKSSSPAVALSAGVSWAGVGVLAGLFAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9P2</accession>
    <name>A0AAE0N9P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_453180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9P2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="504"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="834" mass="93489" checksum="43C97BC33147F083" modified="2024-05-29" version="1">MEVAHPTAGWEQLGERFYRKIQLYTQIFNQDLDLDSFLVAGAQYGGAIALYRDENKLVAYRPAKEKKPSIDIYSCAGKLIRSISWDKGPIKGLGWSEDEKLLVVTADGTVRCYYDLQGDFTQFSLGNGADEAGVKSCKFYDHGLVALLSNNALVSVSSYDEPRPKLLAPPPEGDVHSWNLIPPAYTLSRSVEVLLSIGQTVYVSDATECEDRFLDIGPFTHIAVSPNGKFAALYTATGSAHVITSDFQNRLSEYDSKSKILPKYFEWCGNDAVVIAWEDEVHLVGPAGSLTRFYYDNGRVHLVPDFDGVRVIANDTCDFLQKVPDVIEEVFRLGTDSAASILLDAVEQLEMQSPKADDNIQLIRSHLVDAVDTCVNAAGHEFNIHWQKRLLNAASFGKSVLDIYNSDDFVDMCETLRVLNAVRFYEVGLPLSYEQYQRLSPSGLIARLLNRHEYLLALRIAGYLRLPTDKIYVHWASTKVRVGAEDDDAICRKVVEKLSGKPGISFEAIARAAYDEGRGRLATELLNHEPRAGRQVPLLLSMEEDEVALDKAIESGDTDLVYFVLHQLKRKLPLASFFRVINTRPTATALVEASARLRDSDGQEDTALLKDLYYQDDRRLDGAAVFVREALRQPDSRTAVDKLTLAAKLLTDNAKENVFELTALKEAATLLRMQEAFDRDLTDSFSGLSVNQTMFKLIRLGYHGRAKKIQSEFKVPEKVAWWIRLQALVAKRDWNEIEEVSRVRKSPIGWEPFFNQTLLAGNLRLAALFIPKCTGLEPGQAITMYEKCNMRVKAAEEAVRIKDAESWSKLLDAAGRNTQEGREIERLGQAVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9P7</accession>
    <name>A0AAE0N9P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_482865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119976" checksum="2ED927492755DCC4" modified="2024-05-29" version="1">MAQYAASAAQHSSLSPTSPVAASSSSSSGGPAPSSAGGSRPVAGSGAGSGAGAGFAAGPRAGSGSGSGVGSGAGPASGPGFGIGPGAGPAASASSSVAGGAPNSAHKRVYQACIPCRRRKVRCDLGSVDDPHDPPCVRCRRESKECYFSATRRKRKADDGTIESVEELEQDDYILRNGRKQMRGAESPVASSIDRRLYSEVPLTPGGSQGRSHPLPRPGEPPKSADGTRSSTVGEFGSGEPNMPLENFEARSVMRREVYGPHDALDLLYKAATDKLVDSRHVSPQRLPRTDIAALFSPSSHTRDDGPVQQRGSAQTSTLHSHPDAHGRRTSFNSHAPAGGYHSRHASRQEGAASRAIDPELIKREPSTEPGYADALKTWARFRFVRAGWFTAQEAIDYIDYYYKYLSPLTPISPPTFHNPSSHLTLLTEEPILTVTLLTIASRYRKMPGPGGHCRSHAIHEQLWTYLRGMIERVVWGQEAFGGGFCGSGADDIQNSSTAPWRGLRRGSLRTFGTIESLMILTEWHPRALHFPPSEAIDELLLPSYESQNPVDSDGNQRPAGVGGRRIESWLEPAWRSDRMCWMLLSAGMGLAYELGVFDDIEELLAAGAITRPEYEEEAYRLRAARIKKLLLIYLSQLAGRLGWTNMVPENLRKSDPVARKRVHSVVEGATPATNLSSLSNAFNYIPDLELDDQIIHCWAGISNAMHIGNEKLFRSRKHTTDIIQSGKYLGYLKELQPTLREWWKEFERFKMPLYIRHILTIEYEYVRIYINSLALQAVVERCTNNAGGGSAPGGSVSGHSAPQLSPQTQNYYGKLPLGQLGGFGAEDQEYVREVVNGSRNLLRTVVDGLLPGDYLKHAPVRTYFRIISGAMFLLKTFALGAPKSDVEISIGLMDRTVDALKNCVVDDVHLGIRFSDMLETLTTRLRNRFIHAPVPPLSTMDGRSPAPHHADGANGSSANGHGLQSHQAPDMWMKFREGTGGPERSSTPANISATPWDLTSGSFPYPSGSASMFGPSTPAAAPGLHDHHGNGNNHANGLTESLTFDNSDWTNPSSEMWYLPAGPAFFQNIDNTSVSMTAEGVNVNGVDLLDFMAMDPMDQSFMDGNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBW4</accession>
    <name>A0AAE0NBW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">B0H63DRAFT_225528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBW4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3377775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="87" mass="9530" checksum="5F6C560BFE5CC890" modified="2024-05-29" version="1">MASQLLPLELIDKCVGSRIWVIMKGDKEFSGTLVGFDDYVNMVLEDVTEFDYQGEHLKLKKILLNGNNICMLIPGGEGPLATTSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC11</accession>
    <name>A0AAE0NC11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_478347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC11"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="44140" checksum="1EC072BBFDF88F4D" modified="2024-05-29" version="1">MKQYTSRPARMASGAGAAEKQHAEEPEAKKMRLVKPRIVKKVTRFEDLEPANPFPSLRHTASSGERSNNASPRQNPSAIPSRQTKPAYSCRDRFFTPVVKTEPDLEPTPAAALALIARQKNPKPGPTTVKISISPFFKSLMTAFHVDSPARVSFTNNSLVPFTGHHQQSLPRQLSPVTERDELIRQLKDHFLSTADNLHQRAMSDLAKVHDNLARKLRHAMDADNAVLRRLRKQVRTISKPLSEFTVASQLRGPDGVLKPKASTVGALHAEAQGQLEELEAQINQLWKDWAASEIELEKIRNECFPPDASPATEGKKRKRDEDDAEPSAPAVAGGQLEKRVAEILEAIEENIQKAEEEVIDLGNTTARLMKEIERDYRKAVIPDLHLYYQSIDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCK8</accession>
    <name>A0AAE0NCK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_248219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCK8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="191" mass="21107" checksum="D3053BEB2B96DB86" modified="2024-05-29" version="1">MLVEPPWTKRDEQTTRNGHPISSTVGLLPRGSCILLRAVETDGGQLVPGLSYWLACLQRFSFGGPMRGTPPPFSVTERKTLSLGSSISDRHANPILASHSHVITKSTLTPLVPTSQSPGCFRILFVVRQGLRQRRYVTRHKTPSRQLHPSLLSADCQLIWLASSFTFLLLSSLPLTVLLCLLPVSVIFDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGR5</accession>
    <name>A0AAE0NGR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_197530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGR5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="19630" checksum="46771B011E805DCA" modified="2024-05-29" version="1">MPSVFEENSDDDLTVNRTQISALDAQQNYLRLWTMRLLYHDDAGKVRLTEDLLNGNIPRYAILSHTWGSEEVVFADIKDSTGESKTGFAKIKFCGHQAQLDGLKYFWVDICCIEKSNNTELQEVINSMFRWYHRAAKCYVYLADVSTRTPNDQSSWIPAFWVSRWFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHW5</accession>
    <name>A0AAE0NHW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_397281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHW5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="37924" checksum="4DEC301E0834C9D4" modified="2024-05-29" version="1">MVYRRLGNSGLHVSALGLGGWLTFGGQVENDITTACLKQAYDCGINFFDTAESYAGGQSEVAMGQAIKELKWKRNDIVISTKLNWGGANGEVLVNNHGLSRKHIVEGLRESLKRLDLEYVDIVYAHRPDRLTPMEEVVRAFNHVIEIKGWAMYWGTSEWSADEIVEACGIAKQLGLIAPVVEQPFYNLLHRKKVEGEYQRLYSRFGLGLTTFSPLKFGLLSGKYNDSPDAPPPGSRFAKGDDKFVNYMRDNYGNKAWQDDIDKTRKLKAVADKVGIHLSELALAWVLKNPNVSSVITGASRPEQIVENVKALQSLDKLTPAIMAEIDTIVDAPELDPARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI32</accession>
    <name>A0AAE0NI32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_451151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI32"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="366" mass="40630" checksum="E320C921AFA39530" modified="2024-05-29" version="1">MARLSHLAFRESEAIAAIRGQGLPSFMGRQLIRLCVISGIRHHPAFAEGPSKALHGILLEFTRSLNAQAIMSNRIPDIGEDAQIDDFPTASGTLTSLMKTPTVVSLPDTPACYLDLYLELEVLPKVSVAEEARANGNTAIFNAIMAQPHIYSVMDDYTRTISLSNVQPALLNGDTAVRPMLDIKQHFSIPHARWYGYGSSNGFEPQRYGLGEDMNITEPEINIYGLDEYIFPAPKPKPTPPWAASMASLLANPLPQDLPMGDKDILIPMAAYYGDIDRYVRLRRPVIIRGENYCIVRGIYHNTMFANWFSRPENIERALAIIPGSNGLQTLKAAIHARFIMSNDLSRLPPDEITKKIPVSELPHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ52</accession>
    <name>A0AAE0NQ52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_473369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ52"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042110846" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8749" checksum="AEFD063525ACCF0B" modified="2024-05-29" version="1">MLRWWVALTTILENKFALALTARKVIPALHDSNHPLNECGTGRQKHARPPEMVEKTTMGETGLLAKVPPVPVIALEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR47</accession>
    <name>A0AAE0NR47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_544782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="975"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3386161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1314" mass="145127" checksum="4533BDA90ECC0641" modified="2024-05-29" version="1">MAEAAVGLVGLVSSVVTFVDVSAKIISLIRECSDPAGSGLIRDIETQLPLLAKIFEDIKQDAQAQNLSSVAAAPLQQAIDGCLRQANIIESLIARMVVDSKASKMKRTLGVMRRIAGDKKLNDAWRILESYKTTVILHVSWSKQPPTPPPNTPSASSRLLFNIPKAGVANFIGREKILQKLTTLLLSANGTAFQADRAAVLHGMGGQGKTQIAVEFCRRTNSQAVFSSIFWIDSSSIESMVRDYESLAAKMATGKTQFPDSQAAVEYAKRHISSSASPWLLVFDNLDVPAVFEKIRDYLPDISSGAVLYVSRHTDTSRLGTPILVEGLDPSDSVELLLTQSRSVRNDPNVEAATEIASELGHLPLAIDQAAAYIYSRRVELHDFMDHYSKHKTDILKRTPRLWEYQKTFGSSNTTATTVFTTWEMSFELLAQEPNGPQIAHLLTLGAFFHNQCLHRDLFRESLSHSPQPWTDCMGTGGEWDEYKFQDLLANMLSLSLIQSLDLSNGDVCFTIHPLVQEWLQYRLSEAESCSYACEAVVTLARTVDPEHLSRLPLNMKQRLVANTDACLANADKILTNAASPEFQELRPLLGVLAAVYEECIRFSSAEHLHQLAYRTAQSAGDDIEGESSAAFNLAGVYLCLGRYDKARALYRQATKERETRLGLEHQQTLRAKYGCAIAESYLKRYDQAKALLEDVLRIQTLFLPELRRDIVNTLSELANVYRLSKHLEEARSLYEMAVVERVKHLGHEHPESLASLEGLAIVYRNQKRLDEATILYQHIADGLKSMFGLEHPRTLRTMVNYAIALVHQSKYAEAVQLLEKAAEGFESLLGAAHPDTAWSKVHLEDARLIRDNVYNQMLLHYGLQMAMSVLYRDVPAPRSDIAARERALMPKPVETVPLSWSAVNSMFDDSGARRIELAAANHGAHRDLTATRRMGEVPKCPNPELASKLGYTYGEFADTMQKLFGITQCILDGEGQSALHRAAYVGDTPLLRILLSRPDAKPDQPAPYSLETPLVRAIIGNQEEAVALLLKQPGVDLNSRDSSSRTPLIHAAWKNNPRIVRQLLDTNAISVNLSGEHSEYSGCHDTALAWAANNGNEEIVCLLLDAGARDNLPIKKSALLSAVERGHEAIAMLLLERASSDVTFTTASGYTVLHDVRSAELCKTLLDRGGRKVIDAVNKVGQTPLLRAQGGVAKVLLDHGADPSIRTKMGETPLLRAVRMWQHDKIGFLLATRTAETDIPDEKGETPLTVAFRRGDQKSVTLLLEAGAAVDYDDLGALDFGQGNVTKKTKEEMLQFVRDFRSDGQVEAVVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR54</accession>
    <name>A0AAE0NR54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_189716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="67"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="381" mass="41845" checksum="918445ADC498935B" modified="2024-05-29" version="1">MWRLGARLELSSSTPSTGGPSRQIEPFEYCELRLAGKLPAQPIPNLGSQTAMTIWTLTALATVFLAVRVYCKEWRLRGLWWDDWVLILSWACFITNSSLCQKVIDLGFGKFPCDIPQENMSAIGLIGGDIGATFSILAILWSKSSFGITILRLTTGKLHAFVLFLVVSMNIAMLLQVFFVWFKCNPVSKTWNPMEPGTCWDTHVSNGYGVFSGVFSGVCDIVLAFLPWKIVWNLKMQTREKLGVAIAMSLGVFASATAFVKSAMLLTMGDRNFTYDGSSLLVWTAAEIGTTIMASCIPVMRVFVRTLHKEARSGRQAGPDTGSTPTAATSLRGRATVSESSTDILQARKFVVEYARGKAPAMNQRSSPGKSMYGMSTTEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRP1</accession>
    <name>A0AAE0NRP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_558131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRP1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042199714" evidence="3">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="53"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="45357" checksum="1FFB9D80DF4D58EE" modified="2024-05-29" version="1">MVGILAFSIFVLAPCLAAAAASNEQRPLTKNPSLRRSSGAVRIREALWYDVGYSLNISVGSPPQEIEVYLDISSHDSWIEPTDINPRDKLCKEAAAFDTAASTSFVATNTFARFHFDWMWGKGNLSYDTVGFGGGVAAADQAFAVPEYVSGDGFGFNTCPMAGIIGLAPFSSRRESDDFGEPSSVVSMVRQGVLERNLFAMRLRDPGAELSFGRVNNDLFQGGGWLAEVPLTRNVSGKWDGGWQTTASFLSIEVSSDDDDDDDDNKKEKSFQADLGGVPATFTTRDRGIHVPEALYHRIYAAAGFQHGGWFPPTVDCTNRFAMPNITFTLEGDQNLTLTAFDYTEPWQLDGPDYPPSCTCMFYTSSGFHWSKEIILGSSFLRKYYTVFDLDTDTIRFSSSVGAVTDLMMPSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS25</accession>
    <name>A0AAE0NS25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_139397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS25"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="325" mass="35733" checksum="E9295E66158339A4" modified="2024-05-29" version="1">MTTERINIIITGAGGLVGPLLASRLLHEPQYHLVLTDLADPIVPKGVKYPENATCMKGDITDPAFVQSLIDAARPVGAVFIFHGIMSSGSEANFELSLRVNLDSVRLLLDSLRRDTPGVRVVYASSQAVYGQPLPTRVTDDVATTPEGTYGAHKLMTEIYLNDLHRKGYLNAFIVRFPTISVRPGKPTAAASSFLSGIIREPMNGQECVIPIQDRAFRSFLSSPSTVAENLMRVLKLDPAALPAHRRHINFPGISLSVQDLMDSLAKHGGEDKLKLLREETDPVQERILRSWPQDFDISTPLRLGLVVDKSGDDLVKEYIDSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF6</accession>
    <name>A0AAE0NSF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_141330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="233"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="795" mass="89768" checksum="C0E71262EF143EF1" modified="2024-05-29" version="1">MSSTAIVPATQGGNGTGSACRICRDLFAKKFEQKPPPKNFLLRLFSRQQKRVKKFHEGVMSSLESSCPVCNVFLQLLPYDKDGVISDGNQQFSFRLQDDFTYPRARGLDEKFRLEIYRLKPSSSAFQSSGERSICLDMSVAHESPLRSRIFRRPPVADDSSDDVFTTLRLQMYYCILRGSPRTNNTKQGSHHVCYRRVVPMPLRVLDVKAPGLGHDVKLRLSSDIPDNEPKLYAALSYVWGEDPASKAAQLRTTKQTYQQHLSRIPLTRLPQSLRDAVKVARGLTIRYLWIDALCIIQDDTKDMAAQIDTMGDIYTNACVTICASSASGCNQGFLRQRNFPHFTIPYSHHGREDPSPVTFTEPKSYPTFGEEPIHGRGWTFQETILSRRIIFFTSAGPYFWCRTPSSRDLGVATPPFDHYLTHAHLRELLDIHGAELPLSPRFRWLWLVTQYSQRVLKEPALNRDLALRGIIQHHRTERGGAAVNVAGAWSDSLYLDLIWRTAPKGRHLTDHPTDGRAPLDTFPTWSWMSFFGQVEYPKLSKAILGSADTAPPGAMVSSSSRPSRRPDEVKDSEIKGRADFGELPKLIASISPVTGRLQNGYGPLTITGKVKKVVVPAWEKPLTYNAFSDEEWLNDPGHLKLCAADDLLPPRERDCYGSALWDEKECKYRSFALFGTRDKVGTITFDNYSENPYMEFAREDRLEGLKPKVYECLLIVSLQPFEYEMTTMEGPNGGPGRQIMARVSRRSYALVLEKVEGAGKNVRRRVGLMTAGMASIPRGEEYLNDGKKMTFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT77</accession>
    <name>A0AAE0NT77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_431112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT77"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="32"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="312" mass="35077" checksum="25241614110049F3" modified="2024-05-29" version="1">MAAVYKTLSKSSAKDEDGSNTTSVPAAKRNKQKVLILSSRGVTYRHRHLLNDLAAMLPHSRKDVKFDSKSKLYQLNELAELYNCNNVMFFEARKGKDLYMWFSKVPNGPTVKFHAQNLHTMEELHFTGNCLKGSRPILSFDATFESEPHLKVIKELFLHMFGVPQGARKSKPFVDHVMGFSIADGKIWIRNYEVREVEKTKGEDEAEAAAKAKKMKGGDRDTDVTLVEIGPRFVLTPIVIQEGAFGGPIIYENKRFVSPNQVRSDLRRSKAGRHNARAEQQRAGLAKKENLGLLSNGAKKNVDALDTREVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUH4</accession>
    <name>A0AAE0NUH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gaba permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_166881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUH4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="547" mass="58204" checksum="700F4E1384E54020" modified="2024-05-29" version="1">MAHHDVAVADGPVSRTRSHGTVNGGEAPTDTASADEMLAGLGYKAELVRTRSTWHVAFMSFVLASIPYGLATTLYYPLQGGGPAVVIWGWVAVSLIILCVAASLGEITSVYPTAGGVYYQTYMLAPPSFRKVAAYMCGWAYVVGNITITLAVNFGTTLFFVACINVFETEVEGEPTGVWQAEVYQIFLVFVAITLVCNAISAFANKYLHILDTFAIFWTFAGIIAILITVLAVAKEGRRSAKFALTEFTPTSGWPDGWSFMVGLLHAGYATSSTGMIISMCEEVRSPATQVPKAMVITILINLLGGLLFLVPLMFVLPDVAILTALASGQPVPTIIKSAVGSSIGAFLLLLPLLVLSILCGTACTTAASRCTWAFSRDGAIPGSKWWKKVDPKMDLPLNAMMLSMVIQIVLGVIYFGSTTAFNAFSGVGVIALTLSYAAPIAVSMLEGRTQVRNGVFNLGSKLGWFCNIVAVAWSCLALPLFCMPAYLPVTALTVNYAGVVLVGFSAIAAIWYLAWGRKNYQGPPVVGELGAAAIQDLDSDTPPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX42</accession>
    <name>A0AAE0NX42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1014" mass="109945" checksum="3A9C5AA7F1BBF81A" modified="2024-05-29" version="1">MAQLLAPYNNSMRLGQGFNSYIQQICLDHAVLEDTEANQARLERILLAGGASPGSLPAPRSGAAPRGSSLTPSTSSYEQIEPKDATEASESAASVPPEDDEEDYAEAERKRIMGRKGRQTRPIEERPPWVKAQIVTYSSRFVDKLSDVTNAMNISGSLSIKTGTIGGTANGSYVDSDKFKSSDINFHLQVKVTNQLHHPQNYSIFNKIESINDEDFPQVYGDTFISGWEEGGELNAIISMKVSDKSKLTEIKASLEAEMTTPSGIQVGLKGAFELDKKNITKDTETTIAVNWSGGGSIKDPAEEWSIATLKSTAASFPDLVAITPQRTYAILTKYTALESFHLQTKTCRPLDYENAGIYTGALLDHYMDYKVLWKQISQATYELEAGRASIEMAQPSEDMCDLAVIRVQASDTDVKLLTGQAGNNGQSTSDSVHNQTDVTVTKQDLAVTRQTPSGNLAEDKYTYHVFQPSFAGLIKARKVCRFEMSKIVKEVDIIAKHPQLASDPGRDAFFLNPLVFKQMLPILRVRTEHATESERDPYAPLILGYSPPPEHDRPSVSVHQLEATLDEHHTSIKQTLQEVGRKAHDYRIQGIAGEIASVHSRATLLNDLKRLDPTFRPTQLAVWFVVDTVKGIQIHHANGESIRHGTCEGSASHVLDLEPDGSEIIHEVIIKTAVDESGAAVIAQLSVATSLCKVLDTAQEPLPPPPPPPKREKTEGGKPTEKGSAESEAAPKAAEPEPASPPPPEPRKLIGFRTHTFSRPSHDTQWSLRGLVSITFHGTLTTLGLVWGKDAFVPVPSARVLPPLSKDFLALSPAMQKNIRDWSLPRPNGFPGRFLLGHSASTSPAGGAGAGEPQAFNALDKIDFSWRIKSVGFAAAAGAGGKLAGIKVVYFSGKELVHGTYRAETEVWSCAVKSDLLVAKITTGTADGDAVGHISSVEFVRADERGLLPTWPLDISTLRYVGGEPGTAGLLKDRTEVVELAPTAAGVNWSVRGFYGEVTDGLISRLGVVWGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX70</accession>
    <name>A0AAE0NX70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentachlorophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_463517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX70"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="58645" checksum="8FFAB66D74307FCF" modified="2024-05-29" version="1">MSVLPLTSPESNMNELYDVVIAGGGPAGLFLASELAMARASVLVLERDVAPASPLKLQPLGWRGLNTPSIEAFYRRGLLDTIFEPDNKPAFFERLVKTPGFQPGGHFAGILLNANKLDLSRHKYRLPGPGLKPAPAGLDRIEAALNARAESLGVTILRGYSVTKIAAQDDTSVMVEAGGQDGESESFRGRWLVGCDGGRSIIRKAAGFDFVGTDPKFTGYAAHCELDHPEKLERGFCVTKHGLYVSRPPVTLYLLDFDNSAGFDRQTAGPITQEHIQGILNRITGIPELELKITKFHLATSFTDRSKQATSYRKGRVLLAGDAAHIHPPFGGQGLNLGLGDAINLGWKLAATVQQEKTAEGGLVDLALLDTYEKERHPIAQWVLEWTRAQGLALEPSLHSIAVRKLVSDLIDTTDGTNLFIDRVWGLSQRYILGDGKAHAHPLVGSSAPDLELSDDSRLSPKLGSGRGLLVDLEDDAPFRSLLESSKYEAKVGYLHTGAKDKLGLRAFLVRPDGIVAWVADDSEEPDLDAGKLALEQWFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXV9</accession>
    <name>A0AAE0NXV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_102789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXV9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="17573" checksum="46694E685E16D902" modified="2024-05-29" version="1">MPRSTLPTIPLVVFGIIEPILLVIAYITAMSNPRQYFADQSPSFAVAQNQWTPQALGMTLQMANVLLLLAPLAVVACWSRDANTARGFLFCVALADFGHIYATYAAVGPAIFWDYRGWNGAVGGNIAGSAVLNVLRWMTLFGVLGKVEDGEGVVVAKDLKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXX3</accession>
    <name>A0AAE0NXX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_556776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXX3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005071">
        <property type="entry name" value="PRK06489.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041907072" evidence="4">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="369" mass="40422" checksum="43A80844AEDE4B9E" modified="2024-05-29" version="1">MKFQSIFLLALSATATLAQQKNWPTPTHGDFTISNFTFDSGQVLNNLKIHYQTLGKLQVHPDGTTNAVLILHGTTGSSGQFLNPDFAGVLFNPGQVLDTKKYFIIMPDGIGHGNSSKPSTSGLRASFPGYQYSDMTRATYRLLTEHLRVKHTRLVMGVSMGGMHTWTMGTQYPSLSDALMPIACLPTQISGQNRLWRKFIIELIRSDPAWNSGDYTAQPIASLGGALFLVQTMFSSPLYYQSQYPTRDAMDRYVDQLLPHIAEYDANDLLYAWNASHTYDPTEEGLGKIKARGLTAVNTADDMINPPELGVLERVVGSLELRGLGAKAVVVPESSETVGHGSYIKAKLWVDELQLLLAKTGPKGSSSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXX7</accession>
    <name>A0AAE0NXX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_499679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXX7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="34857" checksum="502A9E5689DBE660" modified="2024-05-29" version="1">MRLINTTTLELKSFADDDEVTYQEIMTRDIRSSPVASKKGFHKIAMTCRLAREKHALEWAWIDTCCIDKSSSAELSEAINSMYDYYSKSEICFACLEELNLRRPEPPDDEDSVADSGGSDDGWEVYPKGIQACRWFSRGWTLQGLIAPSNLEFRDSQWNIRGTKKSLSKALEIIAGICEEVLKDGELHWSPVATRMSWAARRNTKRDEDMAYCLLGIFDVNMPLLYGEGGEKAFLRLQEEILKINPNPSLFAWTTDWLTILLERFCGVLATSPSKFRDTPRLLPTTGLQLEPPDISTTRIPPRLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY72</accession>
    <name>A0AAE0NY72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_105798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY72"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="380"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3389952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="662" mass="71410" checksum="635431DA1F02F394" modified="2024-05-29" version="1">MASVTLVALAPPTMATASVVAYADILRHPEQFYSGADIVWVMISSALVFIMIPSLSLIYSGLGNRSFALTLFRLPMLTGAFIGVQWVLWGYLVTFSDSILPSNWWGGESRAGGYKDVLGMPVSVGDGPDTSAVIPELVFALYEGMFASFTAAVVCGGTMHRARPRRFIVFISIWSLLVYDPVARWSWSADGWLRTLGSLDFAGGTPVHIVSGTTVAAFAVFCSIESRGSLRAFARAAVRKVWSRVGHLFHIIWSILRIILLLCSFGRVNLPESQDPPSEAVAPSGGEESFPYNINFVVLGTAFLWFGWAGFNGGSALGGNLRAVSAWTSTHVAACAGGVTGTLWIWIIKGMPDSDTDGELANSPTDETKRNNVMARQAFDRLSVWFFCDGAISGLVAITPAAGYVPVWSAVVFGVVGALGVNFLKKETEVFLRHDPLQIFAVHAGGGVIGMVLTGLFVDSVTVGLDGHSTIPHPEYSMAQRVGYQLADSASGMAYTFFMTLAILYFMKVVAYLFGGLPWSQTAVYSDSNRLEDEFQAIIQQQWRGNLDPEGRPYTVKLGQIEQLQQLGLSPPVELPAQRQPPERPPRDDIPMDQLTARSLSIPPRSASSGGITTPPWGGSTVGSQGMVRPWGATSTTPSASPWIASPIIQEMPTWSGNSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYH1</accession>
    <name>A0AAE0NYH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYH1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="681" mass="73763" checksum="4D2D4E06FE0A805F" modified="2024-05-29" version="1">MSAIMESDGTTEAKGLLVSTSNNVDGVIITLPPTPPPESWIEQALLAHKKKNVKWSNDTTGGKDDYAALLGGLITVPEAVNTGIYVFVFCVAAHAFVAITGANLNGNGKFFSVLRFVIQDIPIAVVCVHQHTLLRTIQCDFLEASLAPVYERRKQQQIKALKKTARGICGKLDKNLSNMSSYDTPQEKEEHMEIMSKLVRRLEDMPKLDDSILNNSGLVAVLQRIISPMRSIPPEAEKVLQIKPRCKALLKKWDKLNAPSRPLAFTKLRVLREATRQPMGREEETRRGMEKFKQWLAEEEEKDAEKKAKLAAAEKATPQNPTSKPETGILKTSTSATALGPNTNSKPSSTITGIIRVKEAKKRSLGLVNSWLSDVSPHLEHGTPSEVEASRLHFKATETSALEGEDPIARHQFAKRFHDGYKLICKPVSARLPPLRPPPPRPPQSGLLALTASAKSQLRRLCRIDLSSFEAAAKSQEAASLFEHELEVTKKKAAQPGGIKHADNTVQLSVILQVWGIYHGLELQLGYIDKNARAFLVPPTSRNVMLGFHKLPPWLHEMKGIGETVWIGVNTGIGDSQPMGPSEGYPQYDEVGPLASQRDIELVAKLPRASGLKQAMEEAESPGAPSATASAASPTAAATIGLGASTGPEASSNSAGVEEVPVSGPVSGGKEAQKDVSVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYP3</accession>
    <name>A0AAE0NYP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYP3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="365" mass="40377" checksum="948761F72833F12D" modified="2024-05-29" version="1">MEHFLSAEPDVDWATKPLERIQQLRRQVTSILEPEANRYVKTLAQKKDAIAALEAQNRQQILDSAKIAYGSLEAVVSALLSIEKGDKPLSRQSETLVAVLDAAADKFSDLSKVSEENMMELGEKAGDCMELGDSAGRFVSDLESKIGALNALISPTFESKNVHDRVLQDKREREGTLRWQLSDAQSSALDVGNAILSWFGSSAVDDAQQRVRDANQALDENLRHQNQAIEDSRRFYRLAIAVRNASAAIFGLKVKVQDMAAEFDAEYSAVTDAQDVENRLCEGLLQLRNHIVSGDWTTTRDKSLQVVLKLLAADDEVLQRQDYFEDAEARIKEAITAVLGDGSVQKLIDGVPLVMEQQLDAALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P082</accession>
    <name>A0AAE0P082_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_466649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P082"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="449" mass="48968" checksum="83E3B1E4F51F1B64" modified="2024-05-29" version="1">MDDYKKFLGETVLTEEKVITYQLLSRALQVNVNVAKQMLYDFHRTQNARRVESVHATYLVYGVKKAEDGTSQSRNGINDDVDMTSSMPEVDSLGEVVPTLTLSLIQEERLRDALAEYEEVSSIHVYSVGPHPAKDLALLADVAQKALMLHGSQDTKAYATIHNPFVHQRERKDRPVAAPVKTAPIATKVAPRQEAKPSFFKTAAPAPPKPKGDVKPLAEAPSETEKATSSATAPFSKKPTPSLKRGGSSNSAGGIMQAFSKAATKKIKKETETSQPATPSGDDSSIQPLSDDGEDDSEVVPQPKSRAGQKSKSEREEALRQMMEQDDVEEEEPAETPHEDDRMDDEEPPAEPEPPKEEKAEVITTSGDGRRRGKRKIMKKKQIMDDQGYLVTIQEPGWESFSEDEPAPPPPPKAKAASSGHSGPALASKGKKNAPKGSQGSIMSFFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0Q4</accession>
    <name>A0AAE0P0Q4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_132917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0Q4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71515" checksum="9ABBF64C5B6A132D" modified="2024-05-29" version="1">MANEAVAQFEGHLARAHDYRESAQWEFMSRELKEAKSLCESPDFPDAARRRREVVGHLGSVERRLGRYELAQKLLEEVLDDEQTTDTQRLEVSGELSVVYRSLNNLDKARDICNEQYQVARRMALKGEEEMCRAIGNLGMANYQMSLQNEIEPDSELLQLAISQVEERVERARQLQEKLRREDPTSKTIRKARTWESIGLDRLTLCHAAAGNTAEAVRYGEMSRQMTKDSPDPTVRALSRFFYGQALLRDDQRDKAMEMFNYTAPDDQCTCAIALCKEPSDEYCEYLTTIVNQGVDLLRYDEQNYNALDYAVFADHAGMQEVILHGLRSTPNLAPDDIKQLLDGAHLKRHYKEIFQEHLRPELSRGGNNNSIQTMRVTYAKLLATDTEKKRLFDDFKFVPYSKFVGHGRLPKSTDKLAITFEDAAKAHHPEDETDFDPYVVFFSYRWIGRKGDPGYPCPDDRHDTQYKRMRNAIEDFLAESKMDPERIHIWLDWACIDQSNKDPGVNALPVIVTQCNAMVSLVDDIYFSRAWCAVEASLFQTLVNSHGQHQWYSHALLSQDPPTIITHSDGTVENNTDTVGKLDKCTADMATINPNDLNVSYESDKPRIAFLHKQSILLGKATSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3S6</accession>
    <name>A0AAE0P3S6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_405971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3S6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="532" mass="56657" checksum="9E5277F74A644C7C" modified="2024-05-29" version="1">MASSKRAKAAPTDDELGDLFEGIGDGKSSSAKPAPPPTKGKPHAADEDLDILADLENQLGEKAPARPHTPRVARDLSSPKPAPAATKRTSTNTPPPSAGLDNAAPLRKSGDSARSYHASFTPSATSSELQESERKAPAEPTQPAASTGGGWWGGLLSTATAAMKQAEAAVKEIQQNEEARKWADQVRGNVGTLKGLSDELRHRALPTFTNILHTLAPPISSHERLLIHITHDLVGYPSLDPLIYGVFNRVMAQVEGGDLLVIQRGQESTVRSPSTEKPSLSFIGGGQSAAGWRDGPWWRQSDTPRDLGLVSGLVEGTKLCRANAEGYANDYFASHGGIDVARQRAVEPVSESNPVRSSDIFLSVQAISVDAEKGLFAGTTAAEKEKNSSTLMEEEDVNSGDLVCFAVFILDPVHEIQYSAVSQSLPARWIRWLDAASPAAPTPATSDDDYVESEFDRVPEEIREIVEGGGVDPREWVAEWVEEAINLSVGVVAQRYVARRMGVGEGGIGKGKQKVESVLEDGGSEAARAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3X6</accession>
    <name>A0AAE0P3X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">phytol kinase</fullName>
            <ecNumber evidence="16">2.7.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_504807</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>phytol + CTP = phytyl phosphate + CDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38055"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17327"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:75483"/>
            <dbReference type="EC" id="2.7.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Cofactor biosynthesis; tocopherol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.182" evidence="16"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010276">
        <property type="term" value="F:phytol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039606">
        <property type="entry name" value="Phytol/farnesol_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32523:SF8">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32523">
        <property type="entry name" value="PHYTOL KINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="19">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3392747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="218" mass="23464" checksum="B5C8DF2403CE1A4C" modified="2024-05-29" version="1">MANPTPQSVDPAALAKVNAEAKDITNRAFAAEMAGELAEALSLHGQALTRRLEGGTSNSTESVDAAINYNGLADIYLRLGVMDMAEESLKLALKIRDYIAYGGRELGPPQAAAATRDKLGRVFEARGDFEKAREIRLRGAAMGETLCGNASCSTPGGALLHTRDLKGCSACKSVFYCSPACQKKDWVKRHKPLCKAYIASQTSGRSFKRHINSNEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P442</accession>
    <name>A0AAE0P442_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_4136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P442"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="361" mass="41494" checksum="5BD7A6136FDB271E" modified="2024-05-29" version="1">MIWRGIWEAWRDCAFYVSSDWSNSDMLLLYLEGFVLMAICMSGRLLEDNTRSLVFCFYAGFCTAQRLVFFVFPNRYQIQFASQQAQHSTGGGILESGVMGGRGFSPRNTRNRRNWKAGIKFRCYQSGKVKIVHHGSRRIPPCHLPPFVIVFSLLLLTSYLRFFFQYACLLVTPVWVRPHGCIGSGWNIMDMVWSPNHYYSGTHGLGSFEEEKKKKREPSQDREKYWVVGRCRCWKPISIASLAASLAVATIQPTMFDGWMDRKVLDISHEWPIRRRIYQITSRTRYVIFYWVASSVVAPRGSSRHAQFIIHVIMSCSSTMNFDLVGQTDGVSRTGCCCKVIRCQLDCLLGCCFPYWVGIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4M0</accession>
    <name>A0AAE0P4M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vta1 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_457943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="45086" checksum="AFD305FDE1DB9F88" modified="2024-05-29" version="1">MADIPAAIKAADSTIWKCAQKAAQLQSAKPIIAYWCEYWVVNQILAKQLHTVNEEALRYTTGLMDKLEQTKAQYSNEDAILDDTAGQAYVEQFAQETLDRAEKVVKANRVTQQTATTFDAAATFFHLVNIWGPPDQETQQKIKYAKWNAARIAKAIRDGRDPNESNPKHEEPQPPALDPNDPEVRGLAGPPTSTAPRPATVEEVPDRDLRRDAAGVSLPHSPASAAPSAVSEGDLQLPGVPTELGPPAGYFDTEPLPSPISPPPHHPLSHQGPPSMPPPSAGWDQRQPSPAWSQGPSIPPPTTAWAPPPSFHQPSASPTAPPTFASNPPPTAAVASPPTSPPVDPYYRNMAPTAHTARPVAPPVAQPVRHVAQAAPVIALDEAVISGAQKHAKWAISALNFEDVPTAVRELRKALDMLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5I9</accession>
    <name>A0AAE0P5I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_458901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3393704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="177" mass="19604" checksum="811C1222E08CBFDF" modified="2024-05-29" version="1">MEARCQCGAVTFMTPLTKPLALYICHCTECRRQTSSAFGTSAIFPRFQLPNDELLSCYTRPTASGHTLYCYFCKRCGTRLIHTTPGKNVVSVKGGCIEGLDWKTAVHIWTKSAMVPIPEGSETHSEESDYTDYGQTQETLDQPTDLRGNGGHAHLERARHLERERISGACELSGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5L2</accession>
    <name>A0AAE0P5L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_385132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="498" mass="54034" checksum="7465A72BA933B91F" modified="2024-05-29" version="1">MANNATAAAESYKLRKEAFVSNLSGGTVSEIAQVCAVAPVAVLLWSILQARQTFFKPYTALGFAVDFLLNVGALLLSVTLYSGAPALLSILLLAAVAFVYAIPPNLAGRRKKPKLPPNALQSKAAAAPLGVLSTKPFLTTYRGNMLVFTCICILAVDFRLFPRRFAKVETWGTSLMDMGVGSFVFSAGIVAARPVLKERADGRTTPLGTRLLRSTRHSLPLLVLGIIRLLSVKGLDYAEHVTEYGVHWNFFFTLGFLPPFVALFQSALRVIPSYAGLALLLGVLYQVVLDSTELKAFILVGPRTDLISMNREGIFSFFGYLAIFLAGQDAGMTVLPRTLNARGTSGRRTTLVLTMAAWCFVWTGLYFVCTDYTYGAGLNVSRRIANLPYILWVVAFNTVLVSAFCLIDTLLFPAFYSANDTKSEREAYNTATSRVLRAYNRNGLAIFLLANLLTGLVNMTVPTLDVGPMATVGILVAYMAFLTAAAVGLDVYDISVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6G0</accession>
    <name>A0AAE0P6G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_444438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6G0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF22">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="22107" checksum="9C640A076A7CF62A" modified="2024-05-29" version="1">MAVDTLVWLQDIDTSMEFRPADSLVMSCGTVTLDLDRGKVLLVWNRKYQIFQLPKGRRNIDESMLSAAVRETYEETGFRVRPLQLDIATRATPPNAGDGSASHQNPNITEGHPSTEFIGACLYPDPDSDLPALKTVYFFAATADSSATPESGTQEPWENLTPFWIHISEAPMKLRFRGEIAAVRKALGDVQKTGYVISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S9</accession>
    <name>A0AAE0P6S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_44489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="33931" checksum="B1C9E46603C9D40A" modified="2024-05-29" version="1">MKGFNHWMNHMTARDAQTYAQQEQEFYAVTLLYKKCFRDVESWRETIESAHKKIVNLYQELCQELDDSEMEQYLPWFKFWVRPNDLSTDDLAVCVVQEKAPFTAMSPLYRLFSRIDEIYVAGEANIATRQFTVDNNPKVLRSLGAILDGQSIHLKVLQKARDTMKEIRRQVQLKCDGERRGLRALPYPFLLAAAPVTDLDPFPVGNDSSAGDNSDEGYSSSLDGSDKGSSSPFPPSSSSSGSSTAPGPSSPNSSSGHGGGSSGGSGNTGGNDGKNASNGGNTTGNGGNGVGNGGAKTKKSGCPACGCTCRNWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P798</accession>
    <name>A0AAE0P798_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroneopterin aldolase/epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_517768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P798"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="3">
        <location>
            <begin position="256"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="382" mass="41346" checksum="D0234698E8FF4E26" modified="2024-05-29" version="1">MPAAKALSTVDLATLSADLSNACINEAAFWTSHSTTGDLSLNDIPANVFNVFDVFRNPTPNNNMAEQEQEQQERQEQQPQLSSLWAVKAAAGESFAVVRVRNLQAVVQAAVDAWGRPNRPQPALVSAEVSFSSPFDSAVEDDKLGEDTVHYGTLSKAILASLVPLTPGSHALQDAVTPATLRDVLEKVWSNLTGYQVDGQLLQNMGSKKSFLTLSRVRFASVTVTLPKATLLGEGISLTAAAVFKDSKVDEFAISFELTNLRVPTLIGINDNERLSKQFIVATLSLDKFDQKLDIYTSIESLIVKALDESSFETLEALGAHLNDLVLANYHCDIYAGPLTGGRDWQVRIRLEKPTAVPFAECPIVEMSAGSNFPRPGKPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7B4</accession>
    <name>A0AAE0P7B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centromere protein H (CENP-H)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_517733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="221" mass="24512" checksum="639F76726750D342" modified="2024-05-29" version="1">MASSEPSSLILPEAEEDVLGLYDKLQQLQLELALLRSENAHASDDNTRLAGEGMDIIQMRILDASAALALRNSVVENVMIAQPILRAVHNATHASKIERDILPCIQQRDLAATKAAKQCLDVQEASDRLAQLELQIIQTSHRNVELAAEVLHLADRAQTNEAQTLDEIHLQSDVTQLDTEMRISRQRWRVVKGTASAVVTGSGIDWARDKQLRDMVLEIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7M1</accession>
    <name>A0AAE0P7M1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-processing protein prp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_533045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7M1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000027">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000034">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="528"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="657"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="98457" checksum="1899C0518C5F4731" modified="2024-05-29" version="1">MSDAAASFPPPGPAAWQFYQPPDGGRAYYFNKITNVTQWDKPVELMTPAELARAKWKEYATEDGRKYWYNTETKVTTWNPPEGFEQTVGANNGTPAAAGLSVEPLATTPGGYAGSGGAPHDNNNYREQRDNRDYRDRDYRDHREHREPLGESRQLTYGNNTQAQAFVPASNDPEYATAEEAEAAFIKLLRRSNVQPDSTWEQTLRAVAKDPQFRAIKDPKDRKTAFEKYCNDVIVQDKERAKERLTKLRADFATMLRSHPEIKHYTRWKTARPIIEGETIFRSTNNEDERRELFSDYVIKLKQAYKENQVATRKSAMDGLIELLPKLNLEPYTRWADAQETIHETDAFKTDDKYKSLSKYDVLTVFQNHVKSLERAFNDSRQREKNKQHRKERQARDNFIAMLAELKASKKIKVGSKWDKIYPLLENDDRYKDLVGQPGSTPMDLFWDVVEEEERAIRSTRNEVLDVIDDKRFDVTAKTTFEEFESAVRDDRRTAGIDRDVLEYIFERQLQEKKAKRSDDDRQSERQQRRAVDSFRSALKRVEPPVSVTDTYDQVKSRIAQSEEFQAVSSEEARQAAFDRHIRRLKEKEEEAEKDRQRRRDRGDGYRGDRGERSHRNGERSARSHTPERDPYEADRRKAIAERERNHRKSSMAESLLSDHRGPRSTDSHHDPAPARERDRRDRRDREPDRDREPRSYRDRERERDHRGVDRDRDRERGRGDYDRRPRADELNHYDRERRTREEDRETTYRRRVIDRDVDELPYGDERPSSSRRPRADDEDDRKDARVAKRPRIETSEHTPRRESIVHHNARTPPKEKEKTPAVSVRAGSEEGEIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8I1</accession>
    <name>A0AAE0P8I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_63389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8I1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="652" mass="72137" checksum="4B2051E493F22EB9" modified="2024-05-29" version="1">MAERQPREGVEMRYSQGDLAILSAELYDPGLAFRSSPRFAGSKKPQPPRKSPEDSSRKRNKHQSPDDDLDREDEEKKRARGRPRLDVKDETAADRRRTQIRLAQRAYRNRKENAIQTLEKRVQELKDTNEEMSNAFMQLHDFAVQTGLLDRIPDFGRQLRATTQKFLTLARNASEDGVRDEEAGHGHGPSQDRTKSSSPERVDRAPPPVPRSSSPMVQLFGGYTVSNEPFSSSDFLADLTNSLNLPAPPTTSSIDYEIVTQPTLANASFGFGSAPDFGFGSFPNPAPFPQPLPPTTLSSQEATFGRRLQRFATERALRLISMPNAPPARIHRVFGFCMLMETRESIRKRLTRSVVRNTQENLYNWQFPFLQLGGAGTHFDTGDMLSSPSNTQHDQQHRIGNQGTIDILKPKNSNGFSTGPFSPEVMDVRDHAIDENMRMVPPDFRGEWYDCDEVEIYFHQRGLIIPPGADYITAEVDTSLFEDTDGPTTNTAANASHQQSSSSSSSSSSSSPDTTTANASQHPSSTPWDLTSQDRGSTSLVDPLLSGIFTQAAASAGYQQNNTNSNPATPTFASSFGNDMGQQQAHNNPTTNNNNNNTSRRVPRPETISLDVNLLIHSLTDRGTCLGRTPGFRKSDINSAFWSAASRIGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVG7</accession>
    <name>A0AAE0TVG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="433" mass="46996" checksum="D161975180B691F6" modified="2024-05-29" version="1">MPRLDSSSEGSPSDTESDSSVHTIPNDPPLLTSFQGPVDDLEPSYDLGFFVSNTEPAPSALRQTTHVVRKLANKAKRASDTSRDSPSYPNKTPKHSGRQSASTSQYSGLDIQLDEVSEYSFDENTHEPITKEEDERSYSAFAAAPVAPIHPAFPRTAIDMFRQIFPTLPLNRSDLNNPVTNVLANAVVKQVPGLRRGFKVSKAQNLGSYLIQATGTILSGEDRCFKCSRGTGVYSECVVSDNPDVVYHSQGACGNCWYNRKGSSCSFRQTDAPDDGGEPAVMNPWAAGAAKSHQRTATPSDDGGDGHSPRQPPPTQSGYGGYGLNDYLSQQQTPAPKLETKLPNYRRPPATNTTPTTPAQAIDSSPPAPSGPSTSSDTLDSRVKAWESRYSGMATSTLLSTQEHLINWQEDLITRQLAMNKVMQARLKDKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVN7</accession>
    <name>A0AAE0TVN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="59687" checksum="02489F29ED21CC78" modified="2024-05-29" version="1">MCIGYLRNFWCPCPKGASHPCQRITKGEYTGAYDWCNEYFRSSFATEFFIPGPPKCPTGVEYMPEEHLYFTKTLCDICVANGCVLDEDSPFPRSLYGRRDPNVNDTAPPRKGPLRQTRRLSMSDSLSKTEYVQAAEGAKTIRRSQSEGPVAAKKTKEYHEQWLGGWKALPTEEPYEDEEEETERSYSYRRRRNPLVDEPERPRRATDDTPRRSNTPPTIVKKTPTARQADSAGQTYNSAVPPATCWGDAVPSPGKTETELEADYTGLLAKFRAAVRVNRNDNVETSEKEEKSPPREKREGGTAPWDSAQKPGRRRAFISKFASPSSSASSPRYLPASPLHSDPFSHAPTEGMSKPAGKQTRIPRKLRYRKPSVASVSSDSSAREIVPTPAVPTPAVPTHAVAEPVVSETALAGTAASPVPRPVSGLPFSFRLNVQPGQTRHLGTSLAEIGRLFSMQMPRPNTIPVPAGGLNLGPAPKPALSPSESDDSQIEDLDIGPPHCPSTPRPSPLHGARLDHPHAHLRTKPQVFATHPGGHRGSPILAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVQ7</accession>
    <name>A0AAE0TVQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_415960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1303"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3381218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1712" mass="189462" checksum="97036D6563B4AFC6" modified="2024-05-29" version="1">MASSPRSLYDEALDIFKKSASNHYHDPKDQQSLADFLNQHASPQESQEAVMSLKADAGKKYGSRKVGDVTIPDTWIANILGNINNFVDAGNFAMKGAPESVGLAWFAVKLTLSAIQSNYELYTFFGTGLTDITEIMLIVRHYDRLYDERGKPHWKASSVVEKLFQDVKAAYRAVLDFSFSIKLHLTAGTLTRIKHGFKDFFGISKDKFVGKLAAIAELKKKIVEGSQAAFQDKTLTQLDGVSNVLAGIADTVKNIESFQETQEKFHHESMQRFDEIKRSLEEFKAATKNKTPWDFALEKFQKHRDALSPLKSSGEALSEAIDARYPGTCQWIIESSHSYRDWEDSDENNILCISGHRGTGKSTVLATVVDHLGNTSEASKPLFYLSCQTRDANGLNSAQVHSADRICNTFLYNLYKLATEDEQNTHLLEACNEVFANPKAKATRVTSKFGKTNKDDELPDFADAFAQVAVRLKQSVILVLDGIDKNLPEKEQVDLFEKLQDLMKTDDIMQNTGVQVKVIVACDVRTKFFSLIGQEFPEACVDINTWNREDINTVVTAALKNVPGLSAAEQEEARVAIIDEAGYRFNYAVSAAIPFIQQPFQRPLSKRLEALPGGMSDTYTEALRQMSPNYVELLRTAVTWVLLSPEVPLGYPKASEIMDAFQGVYDTPVDPGVDTEPMENPEFPAPSRLLIEQLQGASGPFIEMIPTSFQSEEQWVYAPNQQVEEFCFNQAKRHDHKEMTNDQNTLCLRCKSALSESTDLYIDKKEGHLQMALTCVRHLNHPLFQARAGLLAGKQKETEKDEATASAQLEDETTKDKVNEETIKETEEPNEYGYETDDSRDEEKFLSGEQEEEQDGAGDVDAEENVTVRLRYEIQYWPYHLREAESLWPVEERAGNATWAALMAELDKFASAVPDIFATWAQAYYKTIMDMAWLYNFLMYPGNLPKPLHIAANLGLTSWAEHLLDRGEDVNGLMGEDPPLQLAAYQKNNHEMLKLLLTRGGDIMAATPNTEPAFHYWLVREPDISVDAVQLMLDHGAKPDGVNGAEKYTALFYYAMGGKDPAVLQLLLKHGADINATNAQKITPLHMLLSRREVPRELLEAFVSNGADVNAEDDESVRPLQMASVWGELENLKILLRPGVEEIDDTDNDGNTALHQATINKHAACVRLLAEAGADPNLSNKRGRAGIHHAAAGGARDCVEVLLEYDKSHNGHLGINDPDKSGRTPFFFACDSQDEDTACLILDALLERNIPLAEINKPSATGRTPLGMAAARGFSRVLSKLKDTAMAHNNLEGLAINTQDSRKGMTPLHRAAIRGQVDCVRLLLAMKADATVAEKLQSRTALVLAYEQWAVASERTSYEETIALLIEHDPSGAVHDAELAAICAANGSVRLLRQLWSLNADLNRRDRYGWTPLELARKSSQTSAAEFLKQQAAWVGLLPAEWATTFPATTVLGARAIRDDGTTLIWTDRSAVTFAADKPLPAGLEKFYFEITLQAPPSSITTSTTATEDEDNFSSLVAIGFSTIGGAAMVLPGHPHPHGSGRSWAWHADDGGLYASERGDQKSEYLEWRYKVGDTVGCGVDLSTQEIWFTLNGKRRDEGFRGVDGRMFPVVGFRDAEVQVVTNFGGEVFVWRGLREEYEEKVDTQDTDKTAGGQKEADAEGSGSGPATFVEEVPSPVAVEPLAGGELATAKKFHIEVTTQAIVEGIETLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVX1</accession>
    <name>A0AAE0TVX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_208581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="604" mass="66147" checksum="D60C57F094CAAF99" modified="2024-05-29" version="1">MAPKSAKAAAANMSSSTKKAAAKPSSIPDIDPNSSFTPESFERELKALAAKAKDETWGRFAAQQATIYLKSITFLSLIAVYSNVSQLALSPVYGSIPSARWHSKLIMAACFAGWSSNLFLSRTLRIKPVVLLPIIAIYIPTLQFFLYKASGLLTAYWGPLVTEALTLFPLMSITAACVATDLEGADLSALPGWLADATPGLGSYGLFKAAEKVSGSLIEKYVGTSFFNTRLGLEILLAASYTLLAPSKLLVFTLPALLHTALLNTHVPTPMALVSLNATLKSDGWTILDRRESLTGYISVMDNTVDGFRVMRCDHSLLGGEWVKFIGTGQFKGNQVAEPIYGVFAMLEAVRLVEAPHPISDSDAKALVIGLGIGTTPAALVAHGIDTTVVEIDPVVHEFAEKYFQLPENHTSVIEDAVSYTSRLANESTAPFDYIIHDVFTGGAEPIALFTLEFLQNLNALLKPEGVIAINYAGDFALPPPKVIVQTIRQVFPSCRIFREHPRDEADFEKSQRDFTNMVIFCTKLEKGISFREPTRRDMLNSPSREMFLTPKHEVRDADFLAGEDDGILTRNDTQKLVKWHETSALGHWTIMRTVLPPAVWEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ41</accession>
    <name>A0AAE0TZ41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP cyclohydrolase 1 type 2/Nif3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_449063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ41"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="312" mass="34076" checksum="F4FC6D3454A5BACB" modified="2024-05-29" version="1">MAANLQSPAFTQQVIQAMRSLYPEELADRSWDNVGLLQGNIDYKAGSSPAARLASPTVLLTNDLTVRVADEAIRKRASVIVSYHPFIFRGLKQITLDDPQQRIVLQLAQHNIAVYSPHTAVDAAPGGMNDWLADMLDSHGVTTKRSVVQPISGPLPQGFGGAGFGRLVEFGHPVNLGRIVEAYAAGLGGLRHVMVARPKNSAHQDEPNVIKSVAICAGSGYDVLKDCAADLIVTGEITHHSALRLTMLGRCVLTVFHSNSERRFLKTRLQPQLLAILRKEDAEAQVLVSEEDEDPFEIWDVKNMPPSAYDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U077</accession>
    <name>A0AAE0U077_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_494735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U077"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="84" mass="10311" checksum="EB6B1253E6738528" modified="2024-05-29" version="1">MCDYTQREYQCGHFRWIASKWCKDYTMTHKRCQPNVTHFEYRLVVEHENTNRMLTDELTGECKPKTYPPWENMIRRSKHSSTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0A9</accession>
    <name>A0AAE0U0A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_394255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0A9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047460" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43575" checksum="855A1C3E39273E45" modified="2024-05-29" version="1">MPTIVVLIFVLSALHTGNLAGPLHAIKDKAQSVTGIGSVPGNPPPNVQEPTRKTTPFGELLFDLWAPIKVPANAKSYTDQRGEVWTNNGNTHWTHGMGKGVLIIELDTRNPIGTNEIFNPDKLNWETMSSLLSVSHMNHFMYSQIHGYDYKFFNARHMEGHHDTWIKPHVLMDMLWFYRFVVFIDADAIIQHLELPIEFLFNRWNITDRTSIAMPIDTEQINEQSGEAMTRDQKGKLLLNSGVVVVQNLPHTFDMLTAWKDCTNGKRYPGCGHWKENWSHEQRAFAEYIRYDYNPDGNNIVEIPCNEAMGYPGLKGKVGVIADCKGEFIRHHTIDKNMAKTSTGDAVMQSMGELIQKNFARNKEDLFIEETQKLPRRSPNALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0K9</accession>
    <name>A0AAE0U0K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">B0H63DRAFT_137312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0K9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="365" mass="39549" checksum="B32180BC97DB1140" modified="2024-05-29" version="1">MCKSPLHALLTSMPKCEHHLHLEGTLSCELLFSLAEANTIPLPSGPEFASPAALRARYAAFTSLDDFLAYYYIGFSVLLTASDFEQLTYAYLSRAAHENVRHAEIFFDPQGHTSRGVSVSAIVEGFQAAAKRAAQEFRITALLIPCLLRHLPVADSKACFESLVAAGHFDARKGGEAEPGFAGLGLCSTELSQPPAHWAEIFAAAKSKGIRRTVHAGEEGPARYVAAALADLGAMRIDHGVRAAEDDAVIEKLAEQGVLVTVCPVSNVCLRVAKSVAESPLSVFVDKGVKFSLNSDDPAYFGDHYIQDVYCAVEEAFGFSIEQWAKIVRDAVDGSWCTEERKAVIREEIDGGYCYGKLQGILRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0L3</accession>
    <name>A0AAE0U0L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_467785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0L3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="121" mass="13505" checksum="84F67B60BD2F82F5" modified="2024-05-29" version="1">MEESSRQLLGTKDNCFNQTTLHLSFTEWKSPLWMETAVGLRDTQCMHMEAGVSVRDSGQWVADVDIMEALKHGSVQFLSLQEGKCTHSAPQPPDRHILGLETWDPILDCPDGIVVTKSHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0L4</accession>
    <name>A0AAE0U0L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042030170" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="99" mass="9985" checksum="05361E4E413D7731" modified="2024-05-29" version="1">MFVNNKTASLMALTFAASAAATCVTVPAVVNTLHSLPDVAEWVCPGTKMACSKLCGASNVGTNSCTATGSASGTDNPLVNNTYCYECECSDGSVPALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0S8</accession>
    <name>A0AAE0U0S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_136339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0S8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="686" mass="76428" checksum="1927EB15FF41A71A" modified="2024-05-29" version="1">MANSKDRRPRRRFAPIPIETTFERYRKSVPVDELTPSPSPRSPSPSPMPRERRRFAPQLVESSVRRARRVGDEGPATRPTDKTDITPYTNHIYAPKPRRRQSSHGSVPLPIPVPVTPSRPKGHARRESCDDEIADGVFDLVARDAQRKLQEVAMSAFPNSGQRIGGAEHFYVREGSDDDSPRGRTMVRGPGIHLQTRRNSSEEDISWAFKEMQEHAAMVARGRERMSTLDLDNMSMDSPPSDAMGLTSRVSRISLSSSPLWSSRLMSSSSLGPIGETHMPLLRAESPLPTIGESAMPYLRPESPPIRPIGESYMPYIPSAPPGKAANLPFAPAAQIPAETGFGNYASPFISYSQTRDLSLERMRNQHRLRARGSPPMLGADLVFRKCPSPKQTKLEPDHLWDLEKGTTLEEANRDPTEQHGLWRGYCYTNDKTEKLAPADRPNMITTPLPQTLPGDPFAREFGMTAPVERSGETSPPTSTARAGTVPLATQSGSATAARRPEHRTRTQQPKGLHMLHGLQGLDERLKKEKAAADLEEKIAAEFDDKFVTQVYNYLSLGYPALARPYDEELSKISGIQVDELEKDDDAIMDNLWGADEHEVFGNGLHRADSGTTLTPVNSHDNKKIQATGHIMLDSEEKDGICEEDRCPRWKALKLYIFEWARQHPDLNAISPLAWGVGERRGSWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0W0</accession>
    <name>A0AAE0U0W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_140891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0W0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042078263" evidence="1">
        <location>
            <begin position="25"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="318" mass="34370" checksum="CD341C72901107A6" modified="2024-05-29" version="1">MRQAERAVSAYFGAFAIFAQGVLASPSTFPSAIKSRTVPACVDSETIPNLWSVQELSVTYTDDELVSQGNASFILSNHVTRYTESLRCSLRANYVCEFHGTPGDKDLEIWVQLNLQLASITISEPWACDAGSSGVSAHVVGTAEVMLVCPENVERGLTCHSDGDPDYNGMADGSVVLTSPPSKKRAAWLETQSKNARDLKLKSKGGLKKRGNVKVQKQAATTRRGHAAAFAAGRRGGQSRANDGGASLKAARHDHKVEDADKGRADLARLKILDLTEKHRRAAIEEHKRCSPSCRGGAWSKGGARRTLPVLPVFLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1Q8</accession>
    <name>A0AAE0U1Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_165305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1Q8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="366" mass="42028" checksum="735651B1F3EE52EF" modified="2024-05-29" version="1">MSDDEADPELLALLRQHLQGKLTLDEEPNTGVLEGAEYVCDNSIDVALDMRSCKNAAAAIHAQMEQQGYSPAKWSIHELHPKTKDESTIAFIFTMDLLNFSFWSEKPTATRFAVYYRDQRWTGYWSLVAALQRALDEGIPITDSHFWQDEEECTLDVLRHVFRSCTDEEMPLLEQRLACLREAGTVLYEQYKCHPVNLISAAKGSAASLVNLLARDFRCFRDEHRFEGQRKPIRFLKRAQILVADLWACFEGESYGAFHDISKITMFADYRVPQILNSMGCLAYSPPLDAAIRSKKDIPSGGSWEMQLRACSIWCVELIRREIMKQHPKADINAVLIDFFLYDTIKAMELEGTDTTPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1R1</accession>
    <name>A0AAE0U1R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_412569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="299" mass="33157" checksum="7630E1AC5582972B" modified="2024-05-29" version="1">MSTPRKTILVTGATGKQGGALIQHLLLAHDTAAFNIIAVTRDIRSPRALKLGAHFNVSVVSGDMDDPETIFQKIGQVWGVYSVQVNSDDEEAQGKALIDAAVAHDVRHFVYSSGDRGGPEKSPVNPTDVKNFAAKYRIEKHLEEKAAASAQNMTYTILRPVTFFENLTNDIHGKGFARMWEQMGDKKLQFVSTQDIGWFAANSFMRPDVHSNVALTLAGDELTQREADVLFRAAVGSAMPLAPCPVASAVKFFLRGTVGDMFRWFEKEGYGGDVAACRRLYPETKDFKTWIEENKRQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6M0</accession>
    <name>A0AAE0U6M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43586" checksum="A81CDF7DE65CBFDB" modified="2024-05-29" version="1">MLKDSASPLDLVNAAAINLAVCGLCRQPLVVNALFIAFGSVPRAAPMRIRRLTCKIFHLGGVHSGTGMAACLWYVGFVGLFTHQYQPAPLATAVLVLVWLVLALLVAIIVVAHPTFRTKHHDYFELIHRFSNWFILALFWALILMMSSQEPSPGQFLLHLPAFWVQIIITLATIHPWLLLRRVRVIPETLSPHAVRLHFDHTSVKFGQGISVAKHPWADWHSFASFPDRFDTPTTQFSCLVSKAGDWTRSAINEKPTHLWKRGVPTYGFGYVMRMFPRIIVVTTGSGIGPCLSFLGDENRPMMRVVWQTKSPLATYGPRTLDLVRRMDPDPIILDTSITGRVDMLPVVLRLFKQFNAEAVCVISNPKGTKGLVYALELRGVPAYGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7F0</accession>
    <name>A0AAE0U7F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_459209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3393786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="37147" checksum="EEA95C49100AAF5E" modified="2024-05-29" version="1">MPSTHNVDKPWDTEDIDKWKPVTISPDEVAGPFLEESSFMTLFPKYREKYLRDSWPLITKSLDKIGITAVLDLVEGSMTVKTTRKTYDPAAILNARDLIKLLARSVPSPQAIKILEDGMACDIIKIGSMVRNKERFVKRRQRILGQNGTTLKALELLTQTYILVHGNTVSVMGPYKGLKEVRRVVEDTMQNTHPIYLIKELMIKRELAKDPALAHEDWSRYLPNFKKRTLSKRRQPFKVADKSKKTFTPFPPAPEKSKVDMQIESGEYFLGKQAKQRAAEQERAASAKAKKEEKKRERESEFVPPEESAAAKPKKRKVKHVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7V5</accession>
    <name>A0AAE0U7V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_505983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7V5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="247" mass="27702" checksum="68F088C44926C22B" modified="2024-05-29" version="1">MSARVDPVRTEPEEIAAGLYDFHSTSKNGKLSENGFRSTMERGQKLLDESPEIKAHPLLMVGVFAELQRDRLDGLVQDTVYEQDEFMTDLVSNADLKSAEARRSLTRDQQGGDFATSTRRFTNRLEEICNDLDSMVNECRISYEELTFTRDLFMAELSRQDASHASQEAEETRKTGSITNRQAKVSTAIAFVAMMYLPMASVAVRFYSPDTITPIKFLLLTISIWGRKNKPFSPCPSSTLKTAGSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8H0</accession>
    <name>A0AAE0U8H0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_54904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3394687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="45540" checksum="2162D85B7DC45138" modified="2024-05-29" version="1">MAAFFDILASTFGSCLNCFPGSPTLKINSRSFKILRLLGEGGFSYVYLVQDTSTSELFALKKIRCPFGAESVKQALKEVEAYKLFANSPHIIHSVDYSIASERSDPESKTVYVLLPYYRRGNLQDLINANLVNHTRFPEKRLMLLFLGVCRALKDMHQYNGGSRRAERMEVRPNGGNGGNQTAKRGKRPMETGADEDDEHEQQQPLMDEDEGAPVPGGSRSYAHRDIKPGNIMITDSGSDPILMDLGSIAASPLPITSRSLAIATQDVAAEHSTMPYRAPELFDVKTGTVIDTKVDIWSLGCTLYACLVGKSPFEMRSDETGGSLSICVLSGDWRFPDEGPNAKKNKNKGKSNASVGNGGGANGSPDQAGGDDEAISEPIREVVRKCLKVEPSERPDIDELIEMVETVLEELPDDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8H7</accession>
    <name>A0AAE0U8H7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_460788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8H7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="96" mass="10991" checksum="367D3B73228D9462" modified="2024-05-29" version="1">MSREMKGRRLGGGASSWWREGFIGGGGITKRRWACIIIFILPVLWFCARVTLTSRKAKREQAGNSSFFISIYMFSKLFTYYLPLLFIHLSDLDGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Z4</accession>
    <name>A0AAE0U8Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_518277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Z4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="538" mass="59916" checksum="FD887E82D2BB7DFA" modified="2024-05-29" version="1">MDRFNFLSRGRDTTSGNQPPRHNDVSSDDDDEAPLSPRRAGPTARQIQQDLEAQRPRAGSGVEHEQMFERASPAGRTAQRFRIPSWFSVASSRGQGDIHPALRPPRPSSSHYSGDGGPPGTTIVNGGDESPKTTLFRIGEQTLPSTRLHLPNLTRTWTQGSNGPPSRPGTSAAYAAAPAYGISAPAPVHDRSGRRGHRREGSDRSHHRQRRGHRSQRSRDGSTGSEQQDSSRRSRRRRERERERERQRLDHALRGDEVEGSRQESEERRERRERRRRRRERTGPPPKHFLFCFPWIKSRRIRSQILRCFVSGLFLALILTVYLSLSITKNINNSEFTVLLILIILFVTIFFCHGLIRLCMMVVKGGRDDENTQRLPEMSGPGGYAIPQQPIRVTLARDEEAAGIESETTKINPPAYGLWRESVRVDPNRIYWMRNQDASGVDEVVEDDSNNNNNNSSSSSSSSSSSSASSRSNSGGGSDREAGNGARTTVPRPPSYASEDGVSYVVEARPRSMAPSTNVPLAHTHPSETGRAGRPVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U927</accession>
    <name>A0AAE0U927_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_63507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U927"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF294">
        <property type="entry name" value="ACETYLTRANSFERASE MATC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="509" mass="56508" checksum="411589628958C057" modified="2024-05-29" version="1">MIWCGHRSLPQPARVPTDKVVPVYFFDDFPSVRDIVMRWMVCFDDVLDAEKLHAALVKLLERDSWRRLGGRLRVNKHGKLELHVPQQFDAQRRPAVRFSHRVSADINLADHPLAPRIPRPTDGPSLQGGGGGLQQLALGTADNLPQTLADYTSSDEPPIALQVITFRDATLVTLNYSHILMDAVGLSAFITAWCAVLAGRDDDVLPLADHDPLEAVGTSSSRSSQVSEPEEEKEEHVLKSKQLPSIGLFFFIVRFVLDLLFGPAMESRVIFLPNKTVQRLKERAANDLEPDHPFISDGDVLSAWGAKMTALGLGPSCTRPLTIFNVFELRGRLPSVFRSPTSVAYVQNAIFVLSIPFTAKEAQTMPLGQMALRFRAAVAAQTTEPQVHAMVREQRAAIAKYGRPPVFAEASSIILPFTNWQKARFFDILDFGPAVVVDQNDKEKGGTRQNQSAPGKPVFFYAFDPNPKPNPTLRHTFNIVGKDRQGNHWVSGILSPATWSTIEDELKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U9B4</accession>
    <name>A0AAE0U9B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_518353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U9B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="243" mass="26615" checksum="57341D3CD3CF778E" modified="2024-05-29" version="1">MEDKKYILEGQPVTQHKPPVTQVDVFCGLLWLHVIRVRRDCLSGTAITRCATAADIRERYEPNVGGSAGELQKVGEDYMGNMILRIKAKVKQLADACWLIRRAVLKLRDPNYVTHGVKLAKEKGSYDIDQSETGLDFSSWAELGADLEFEIPGTASSSSSYGTSYGTFAGTSSSSSGGNLNLKPDLARKTYSAIDGSMNIMPRRGGARGEDADWEVLFALRVKDMDKICGNDQLGKYLAQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JW28</accession>
    <name>A0AAE0JW28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_490831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000019">
        <property type="protein sequence ID" value="KAK3365448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JW28"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3365448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="359" mass="39833" checksum="3B3DCA010381B6EA" modified="2024-05-29" version="1" fragment="single">ASPASSKLTKLARGSPKLCYRQADIPIAELSDKFRAANASKEAQDIAQTSKPSKSSSFPEASDKAVATGCWPAPPVFLAIVVFGGLTRLSITEWKPWESEFEKYRASPEFKLINPHMDLSDFKRIYFMEWTIVFWTERRPLAPGSHPRVSQYRLATHLAAAFVCYSWMLLAGLKVLRTHKALLTILRVLRGSITGLTALIFTTVLSAPWLQDLTRDSSTMIYSRWAKASFPRSRSCWNRSTAAKEDGSDLWWRNMLENPSLVQLDHRILAMTTFTAVMALFFYSRTARVKGALPKDVRKGVNGLVHLSPLAAAHQAGALALLTGVLVAGQTPAGTSQYHGLGERRLQVDKVIESGINRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JY28</accession>
    <name>A0AAE0JY28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JY28"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="178" mass="20656" checksum="A2E09E74C43FD889" modified="2024-05-29" version="1">MKEKAKHEKERREKKKRREKKKRREKKKRREKKKRREKKKRREKKERKVKATTDVATAVDEKAEGEVKMTLSVNGAVAEQLDILALDRPVRELTGHELLLCSGDVFPKSIRFILKLVLFGIAEHCAVVVMRVQLELVKQDAIDSLQLLDVGVRVVERKLHASEVLEVGGSRLSTDWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0G3</accession>
    <name>A0AAE0K0G3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0G3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042048378" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="95" mass="10153" checksum="18997EEA19063FAA" modified="2024-05-29" version="1">MHFTISTLLVAILAFIISPVGAASAPCRRDVTAALPAGAKYLNETHFEPPTSFAPTKEPYGYCCTAACLVCSFYKCDPVNECSHAFFAHNCCADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K198</accession>
    <name>A0AAE0K198_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_72232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K198"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16452" checksum="FF2A585E77D66173" modified="2024-05-29" version="1">MASISLCRSALRRHAFPLSLALTTGLVMTNKQRPMRFDVLSPPPEASTRNYSSGPNKKEMLNAETIKQLSGGSLSGFCVGLLVSVFSKTLVILVGLSVVLVQVASRYGINVMEQLELKKRVQSSKILTMLSKTTAFKVAFGASFALSAFMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1V6</accession>
    <name>A0AAE0K1V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_488635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28587" checksum="31A274A6BDA45C7D" modified="2024-05-29" version="1">MAPNWGAYWYNALTLRIYDAWVLGFNMGTVWGCRTAEVLLPLFCNNFSRRHLDIGVATGYFPSAALSHLQSISSSTPFISSDSDRTPPQEITLMDLNTSSLKTAKGRIEADHPWRRRQAVRIDLVQGDVLGPIPEALPDGKKFDSISMFNLLHCIPGPPERKTAAFGLAAQILAEDGILFGNTVLGWRYMGWWNPLAWLTMIAFNLVGAFGNWEDSVEVFEAGLRREFEEVETEVVGQMLLFRARRPRRDRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6E6</accession>
    <name>A0AAE0K6E6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_319746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6E6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="140" mass="15896" checksum="656A9B40F661D69D" modified="2024-05-29" version="1">MMCRHVATMPLPFSLSLPYRAMMTYPTPCTTGLVVVYSHSLLFFFLLAWLDDMFTNFFVGYWVRTNLLHIAAIECSVVAIRLLSLRRGFDVCYTFLPPVTLDDPERIAQSSGSMESHAYAVLSRTTGRTKQWLGTYLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K888</accession>
    <name>A0AAE0K888_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_483181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K888"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3371886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="15847" checksum="75E07B30E87DEE15" modified="2024-05-29" version="1">MFTQRQLMRAVPRWTAQLKTPTQRRLASHVPSTGSSTENAFVRERRAVKDHAAGSAELWRKISLYGIPASLLLAGLNAYNLWNQHWEHWSHMPPLEERTEYPFQNIRTRNFPWGDGDKTIFWNPMVNYHNKDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8C4</accession>
    <name>A0AAE0K8C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of cytoskeleton and endocytosis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_287312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55612" checksum="058AA79F3AAED811" modified="2024-05-29" version="1">MQSVTRSFGKLWSKGPGDNAKFSVLLSDYEDADKVLAQIIDNAKLWRDAWASLVTSQLQIVTEYEGLYDPIVGASDGHGREMAETPRVQLERTFRLKEAYTELKTELIDEITTIEDRIVKPAADARDCIAPIRKTIKKRENKRLDYEKMQDKVNKLQRKAGRSPKEDANLAKLEDEMSRAADEFGIADEHLRETLPPIINATFSMVPPLLSNLVQIQNRLLGLYYTTLHNYCEDFGFPSPPPPMSEVVEAWNAAFKKTQSHVESISFIARGKAAHQPMGGTNDPQSRKPSASGPPSKPVIGRASTGLISSTNNGPQQRVQRVPSMNSLRTPNQDPSPQPSPSSTFKRPDYLAPTDFTTATVLGGTPVDRTKPDWTPGASPNSLRPRNGDYFNSRDKRPSTASTEASVASFTSNASQNTVGSYGGNNGFVKKKPPPPPPPKRIPSAKPDEYVVALYAFAGQGEGDLSFQEGDKIKIVKKTGTDQDWWVGELNGKKGNFPANYCKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9G8</accession>
    <name>A0AAE0K9G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_285290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="230" mass="25288" checksum="7B05785265133649" modified="2024-05-29" version="1">MVVPDTAPPYAPAVIETISHEDFETASIRSAAPSYTSDAPSYHSTVPHNSDPVPPYSPPARSEATSGAAPTFQGSLLSIPGLSQPQPAASGAPRQQGLPPVPTGPIRAEPTLGQFRIPSWSTISANPTARHYHNVAMRRMSAANTNATNAERLGRIMLDRIEEEERNRIRPLEDPHLVGEEAAARARQERLARENGDEILIREDRRWDWFLSELSSRQSRPTPRFSLGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAG2</accession>
    <name>A0AAE0KAG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_302036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAG2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3372625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="18974" checksum="E665ACB87E841A4B" modified="2024-05-29" version="1">MATASTYSECVTSLRTSLSFLESSVATLGHGVEDFPRLATVLKTVRHYELIPQPTLAAAESSLRDEIGPFVAILLDRADKHLERQARRIETLKARADLNAGRLSHFPSDKDNTTSFSSKSRPKSKVLDGGAALRAKVVRQRKEALKYSVERLELEVLQKERELRVQLDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEC6</accession>
    <name>A0AAE0KEC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_482056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="69" mass="7730" checksum="DD873DB100B32B93" modified="2024-05-29" version="1">MTKFAESSLPSKALGRIPMMLLFPTLSFSSMSDYEKSTELTKIIHFILFLGVVSTFAPLPIWVSEFPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEI2</accession>
    <name>A0AAE0KEI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_418668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="323"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3374536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129243" checksum="B1919ACF72925D4A" modified="2024-05-29" version="1">MATLNSLKLALRQKAEVTTGNGKKSPLSEAQYSAGFDILARGSSATYRDFIIPHLFHVLAPLFNSRLRISVLEIGPGPKSILGELPLSQRRKISRYTALEPNGLYATRLEEWLQCSTQVGSEGLEELSNSPLPCLENQPGVHRSLFVLDSLQPGVEGGKKYDVILFCHSMYGMKPKRKFIENALEMLADEKRPGGMVVIFHRDSAALRHLDGMVCYQTALFPACSVRVANEDTVLDCFAPFVAGFNFSPSQGREVKLEWWRNVCRTLGRLDENGGHYLLFNAPQRMVTFTRQSATMLLELTAQLMLPLPAEAEIRVKNREARLNRQAAHIIRPTEVEHVQQCVRWALKYNLSLTVLGGGHSGHCLMPNVVSLDMSAFAQVRILVTGGAEAEVDSPLIIAGAGCKTGDIVSKALASGLEVPLGSRPSVGAGLWLQGGIGHLVRLHGLACDSIVGVVMVSVASGKLLYVGNVPSQHRPADAVRPDSEKEEIDLLWAIKGAGTNFGIVISVVFRAYKAQSYWVRNWVVPLPNDFEATRRLCGISEIATQLPQSRTADMYLFWKDGKLRLGVTMFESSTATPFETPTPIPTALLAFLGLEHSGRCVDGVGLFETDMYMTGMMHDGHGGGKTSSFKRCLFLKHVGADVVEILVKAMHARPSPLCYFHLLQGGKAVDDAVAREAGAFGCRNWDFACVITGVWPRDDQGDNEAAQAAAKWVYDVVSDLLPLSCGVYGADLGPDSRDAALAAMAFGPTTGNRLRLARLKRNWDPCSVLVYACPLLKVPKEPKLILLVTGESGAGKDYCAAIWASVFVSNGLVTRAVSISDALKREYAAAMAGVDLNRLLQDRAYKEQHRLALTAFFQAQVQGRPRLPEEQFLSLVYDAAADDVDVLFITGMRDVAPVATFYHLVPDSRLLEVCVKASQETRRGRRRNAADDDKDYKDKGSFKVSADMDYCPDLIFDNDKDNDDDGMAVRRFAETSLLPFVHSDLECLADMVRPVPDFPRPGILFRHVLDIAQHPGGLALCTSLLQKHFPSDWAQVSVLVCCEAGGFVFASALGIAVSIPLALIRKVAGASKGKIPPATISVVKGPSHISGCSSSLKEHPDVERIEMDMDVVPKGVLSVVVIDDVLATGETLCAILRLLVGEAGISAENVTVMVVAEFPIHRGRELLRRLGFGKVSVQSLLVFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF18</accession>
    <name>A0AAE0KF18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_482573</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3375319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="105" mass="11377" checksum="9FFFD6236AEEB0C2" modified="2024-05-29" version="1">MASMLAIGTGAAVAAFLGRAALVAFRRSRGGVGAMGKAFYKGGFEPRMNKREATLILSLSERSLSKDKIRKAHRTLMLLNHPDRGGSPYLATKVNEAKEFLEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF93</accession>
    <name>A0AAE0KF93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxin 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_513111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF93"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="452" mass="50638" checksum="2D2C3C24B5096604" modified="2024-05-29" version="1">MASNPSSYAAAALSPISSLSSSVSSSRNYSTSNISKAYRQASTLFLTRRLPEALSTVLPLVAPPPTDDQNGTPFEPAPVARASRSTRIKVWSLYLTILNAILELDPDEGKEAFGTQEWRAICTKVREGEVWEEVVRNGYHGVEGDVDSDVVINLATILLAHAKNQTLNQKRLENYLAAARTPNLDNIGDRFNPASPRRFRSPAKGINNSGGGADTPRDLNARVKILELYTLHVLLRNNEWDYAREFISMSPVLDEERREAFLQALQSLQEDQQHAERREQEERLQREDELRRSIEDARRLRAENEERERKRLEEERARRDREASEVDYGIERTPSNAGSSGRGARQRPPVPTSSSISRPLPSTKKSEALVAPPPSLGSRATMVFSNIRALVEHIAQYFQSNPALLYRTLAFVVALLLMFGRKSIREKITRVLGSSWDKVRATAGMGVKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKT6</accession>
    <name>A0AAE0KKT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_249329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKT6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="41888" checksum="3C68CA2B2595449F" modified="2024-05-29" version="1">MTTTKTMAIAAPSPTPASTDNTIATTTATTALPCCPQCGSDLSPALFEETQTTLLAAQKQIADLEAQVRLLNHKASAAVDRWADYEDELAKLRAQLSSSQGTPQPPATPPTSSAGGPPSTPSSVSWFSQQQQRQQQTTQSPVRSSFLTAGAAARITALLSSRSSKSTPSPPPPNVKPLPHIPNNAKQLQQEVSPGLASASSNGGNSHSSLGSSWYHYSSSSTGSAGGAVPVSPGLPSTDDLLSALTREQALRLEAEGHLSETSREVEELSVSLFEQANEMVAAERRARFELEKRVETLEKREADKKRRLDRLEGAMDRIERVRVLLGQTGGGGAGPLREENKAGTPISPMGSPPPADEDQRRREKEKTTSSVSSSPTTSAAANSSPSRDKGQKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MZS9</accession>
    <name>A0AAE0MZS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_372460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000018">
        <property type="protein sequence ID" value="KAK3365457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MZS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3365457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="608" mass="67049" checksum="B4A90599A6D0D8AF" modified="2024-05-29" version="1" fragment="single">AAATTATPSGSRGGGGRKKAGGRGAPGPPVVPDVYRELLVEARAEARSAQAQDNSGGLEQRPLKRKRPGEKGVPSRQKEALVLSKPEEAGQNADDSDDDDDDVEFEDVIIPAPTVQTMVRESDDDDDDVVFEDVDVDPGGLLSASAAAGEGQSKDMVLDLNLSAQRNAMTESRRAADRRKPVTREEKERRVQIHKMHLLCLLSHVERRNRWCNDTAVQEAIRPLLTDKMLKSLIPRASLTQFGRTESLKCGVQETSSMFLARFRVTERGLWRALWAEDEEQLKNYKLPEDIDSTLEKSDFLEAAKALKGSRDVGAQLFCALLRCAGVEARLVCSLQPLACVAGGPLMPKQRGNSGALPPKPSKADIYAASMEKHQSKAPVTASPRRRLGHPLAAGYHVPSMTPPPPATPRAPTQSIKPIRGESSFPVYWVEVLDVAHQKWHPVDPLVTCTQWKPRVLEPPASDPKNCLTYVVAFDADGSAKDVTRRYAKAYNSKTRKMRVDGAMVANRTGPEVGLTGERWWRRTMRTYARPWPTDLDQIERNELAAEEAKEPMPRNVADFKDHPVYALERHLRQNEVLIPGAQATGTVGAGSKGPLERIYRRRDVQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2X7</accession>
    <name>A0AAE0N2X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_529140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2X7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="14908" checksum="25733B861D2D8A47" modified="2024-05-29" version="1">MPAAVTPTLNKWRTGKNADGFTLAPILLGNIKRQRDLQPAVQHPQRYRGLYIQSVAGKRVTDLSVRHWDPELQQGWTVGTIEGATSDFSVMIFVDEAEVPATVSAISLFFTTSGAEGGVAGIGEVYPMYEGDEIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Z0</accession>
    <name>A0AAE0N2Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_488022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Z0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="751"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3368218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="100066" checksum="3F390E7034DB8C56" modified="2024-05-29" version="1">MPRIKSFAPSWLNEPAPGHKLFEPSSDDSKIPSALAYARKAKQGPRRTIARRGTEVFVAVGKQIRWGDLVQLKESWEAKHHGSSAGARFKREESTASFDIYDEEAHNGNSQNGALTEGYRVLKTPVADDIRQLIMSPEEDYLAIVTSHTVHICTLPDVSHLHTKEATLLKPKCWTLGPTTHVTSRPAVASVLWHPLGVNGLSLVTVTRDAVVRVWELSPSNRWSFDSPSLAIDAKKLADGSHLDQDFSASTAATNKAFSPDSFDMEVAAACFPGPGSGGWSAMTLWIAMTGGDVYALCPLLPLNWAPPPYLIPSLSVSVAAKVAATEDDPMVSSDARNLAQQQMEWMSDLDNQEPKEMEGSYGKPPAEVYTRPTHPGRYPKLQGPFEFQLNPGDEGEEEEELKDVYVIGEKVDTTDLMFGEEEELDTGDFDQDGLSLSIICLLSTSGQVKVCLDIDGVEAQWLPPRGKPKSRLFQKAPKSPSLLTFQTFDTVKPAEVRSDSWPMFSDDMTSRYSFYVTHSAGITFISLAPWVFRLECELQADSEAGSEFRIDLLAKSQVPERERIYTQAPGHHALAAATAIRDPDLGHFVLSATPHDPVALFFDVPKDDSVPAAAAREATPLHMLPEWREPSEAPPAWEPRPLFHPSESLDHGSALPEWIGHLKTGKRRTLVQQEVRLSIATLEVFSEGHRLVSSEILELNNTVAELFRKCEALQGELREQITRVNAIKPQIEVITGEADVSGDEEPIPQDKFIKDRLRNAQRRQRELKERMERLRVNMGRASGRELSDKERAWMDEVRSLQSSVLGSEAEGGQATSPNKAKQTWKRLEEVKALRDTLFSQAEQLQKRGTDGAGEDAPSSPRSQLRIPTEVRKAKVAQVMAMLDRETALVDATKSRLEKLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N410</accession>
    <name>A0AAE0N410_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N410"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="96" mass="11116" checksum="F6CA3C8B7C6E8FAE" modified="2024-05-29" version="1">MADSLYAYAPIDLATNGIRILRLCQGEPADPIICEPVEIFLDYKMVQDNLYSALRCLRTAGEDRWLWVDALWINQDDPREKTHQVGRMAKIYEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N487</accession>
    <name>A0AAE0N487_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_402434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N487"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="102"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="37273" checksum="11D0DB6F62E08D14" modified="2024-05-29" version="1">MSDASSRLPIVLYHYPYSPFAKRVVWYLVLRGIPYVQCLQPPIMPRPDIARLGVKYRRIPILSIGRDVYLDTRLIIQKLEQLYPSLPKLGAADGTEQKAIERLLEAYAIDGGIFVRASQLLPTDLPLLKDPKFQKDRADFFGGQVSREVAAALRPEAVNEIKNAMELLETTLLADGRDWILKTEQPSLADIEAVWPFHWLAGLPGALPADQVSAQQFPNVYAWIARFQAAVSAAAKKKGAAARPKSVSGDEAHKTILESAFNEANVGVESSEPIAQFHGLKSGHSVELWPTDSGSSHRDTGKLVGLGGKEVVVETDAGVRLHAPRHGFRLRAASTTASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4G1</accession>
    <name>A0AAE0N4G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4G1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61481" checksum="E515275E381AD22D" modified="2024-05-29" version="1">MFHWYQKSQICYAYLADVIEIPDDEGRSSDGKSGPQSFYVDSAAFKSSRWFTRGWTLQELLAPKDIRFFSSSWDYLGRIGRLVEEISSATGIPTQYLTQELSLASASVACKMHWLSRRKTTRREDMAYCMLGIFGINMPLLYGEGDKAFIRLQEEILKSNTDHTLFCWAWTESVPASWTSMLAPNPAVFAQASQFVQNRVSVKPLPYSMTNYGLSITLPMVQAWSYALLMLDVNDTGMSPGGEQYDYEYNRLNYKFCIPVRPRRSEDGIHERERFPPTPIPFEIRRGNLRRHVIVRARADILALSSLGSLGLTGVRGEIDINRRQSPYGFLITIQDTLHLLDGSSKSFKFWSSSAENRVLQDISKAIRFETFPNKHSFDPDSSVFWVNPEGHSRTSGLMKIGRGQDVGCVLYFEVRISAPASSHHVSSSKDVEWNCQAVPAEFWKDSESSKVKLLKRLDLRFKSGRSYQEDEGPYKVEVGEIFRVPVGGLVPAGGKICTTVHLATRPGYNNFDVEHPPEESGEADWEDELSDSSVVARVSGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N620</accession>
    <name>A0AAE0N620_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_453517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N620"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061191" description="DUF7580 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="365"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="574" mass="63755" checksum="17AB7E8479AE9820" modified="2024-05-29" version="1">MSGIELVGVSLAVFPLVITLLEHYQDGCGTIRDFAHFRREFTHLVNEINREQIIFRQQVKGTLRSISDSEFELKEMMDNTQSDGWRSPELNVKLKQKLCSHGEFGNYQASLSAIHDSLANMAKRLNSYQMASMGYRLQKHFRKLQFVIPKKRWREQAVDLGKQIDRVGKLFGEAEALAPARQSRGSSAICQAFEEARRQACSLHEAIIKGFTCACNVPHAFKLVMVKQHKPSSKELQPTSRILRVSFPLSSLHSWTAPWMALEEKDAWCSFDTTIVSPSNSTSTLSADPSDLRESRSSVSFSSLSADSGRSPQRSSFSGSTSTVLTTPTPSTYHGCLSHPFEALQPYTGTTVPPSTTASGVRLFPIDDLCTTIRTRGGDVDVGYLEDSRGAYHLNANVDFSFTSADVGHIISLKAILAGQDGSDVGKGATKTTRPLPRRQRMAIALTLSYALLELFPTPWCPRSLSKLDVYFFQRKNGDIMTENPFYLCESPLSQQQQGSHPLPTAGGMSPSSADDDGSDHSNALLALGIVIMELWFGKTIESRAFYKDYLRRGREGEDVYQPHGRARVTKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7E8</accession>
    <name>A0AAE0N7E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_563682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="485"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="730"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123679" checksum="DE136B3A68F0BF9C" modified="2024-05-29" version="1">MPHPVSPPTQQSSMVVPIKAADGAAPAPAQADVKALLDTIFSAKTSAASIDAAYGLCEILLASVGFRGLQQYGILQEIKKAAADKKSAVRREGAQNLLGALFERFPARQPISEVIFLLQDGGMLNVALDALADKGSVVREAAQYGIDALFKHLSPEALVAGLMPALITYLKKAGGKYQGVAGALKLIQTMADKAKISLGSTQEEAELQDVLREMLGAHLAALIPLVESGMLDMKADVEKQAVKTMNSLTTLLTNDDVAPRIPLLIETMQHPSPEKLQKAIHALSMTTFVAIVTSPVLALLTPFLERSLNNNGTNQEVLRQTVVITENLTKLVHDPIEARTFLPKLQPGIKSVVDRASLPEVRALATRALAVMDKAMGTDKDATVVERTSEADVAKVLDAEIKKNGGLAGDLDTYKVMRPYICEMVAEDVNHRFVKRISANIAPYIKSLMKGADAHDAVAAAVQKFYVDEDARKFGVPEKEDDGETEIVNAHFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLMRSIASGKLEGFPPQDVLRTCYVEHNQGEDAEISILDFVKKDPELAKEGEERISAVLEEVGFTAGPEGRQSHKVGSLSGGWKMKLALARAMLQRADVLLLDEPTNHLDVANIKWLEEYLKSHTEITSLIVSHDSGFLDNVTTDIYHYEPGKKLGHFKGNLNAFVQVRPEAKSYYTLSASNVQFKFPPPGILTGVKSLTRAIIRMTNVSYQYPGAPKPSLSDVSCQLTLSSRVAVIGPNGAGKSTLIKLLTGEVIPTEGKVEKHPNLRIGYIKQHALEHVEMHLEKTPNQYLQWRYANGDDREVYMKQTRVLSDADKEQMDKYIDLGDGNGQRQIELLIGRQKYKKTFQYEVKFRNTLPKYNAQISRETLLELGYDKLVQEFDDHEASREGLGYRELQPSVISKHFDDLGLDPEIANHNEIGSLSGGQKVKVVIAGAMWNNPHLLVLDEPTNFLDRDSLGGLAVAIRDFKGGVVMISHNEEFVGALASEQWHVVDGRVTHKGQSSASASAFEDSKPASAITSAINSGLNTPALSSVVSSAVNSAVNSGAEDNPGEDMKFRARKKKKLTKKDLKERDVRRRLRHIEWLNSPKGTPHPPDTDDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8I7</accession>
    <name>A0AAE0N8I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_480858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8I7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="27440" checksum="4DF35F5BFE3EF761" modified="2024-05-29" version="1">MPKPVFVLLHGAWHSPSCWNKLIAALSSAGYSAVAPALPSSGSATKDWSQDVEVIRNTVGDLVKEQDIVVVMHSFSGMTGGTALEGFDKASCAANGLKGGVIRLVYIVAFLVPEGFQHSAPGTRDNMIPEMRTNLEDGIITVRPEDAKDMFYQDMDDDAVAELAKDLRPQSFGAFWSTTTYAAWRYIPTTYILCTKDKPTTVAAAQYLIASAKASGPHKIDAVLEVEAGHSPFLSQVEWTAETLIKEAARESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N936</accession>
    <name>A0AAE0N936_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_274888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N936"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="130" mass="14740" checksum="83F7F2F3C52E066E" modified="2024-05-29" version="1">MYHMSYLRQVPISYVTPSKLITLSSSVSFISFLSSFFYTSVFLFFSSVSSTTKGSLSSDISSIFCSFVLLFIFFLLTHTHTLRHLSLNFAYPHSLSKRCSNNVFHYHHTTIIIHHTGRSAGERSSRLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N958</accession>
    <name>A0AAE0N958_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_452666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N958"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3374835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="309" mass="32188" checksum="26049285D0E224A8" modified="2024-05-29" version="1">MPDTMRALVGADSGSRYRLAQDAPIPVPPRGMLLVRVHSVAFNSGDANKMVGFAGTVARLGEGVTRFQVGDRVLACSFGPDATGKKSKGGAFAEFALAEQDNSCRLPDAMDFAEACSIGMGLAAVGEQRSMMHGGGEGGTRDDNDDNNNPTVLVSGGATPAGTVATQLLKMAGYTPIVTCSPAENALCQEYGAAACFDNHSPACGADIRVHTDNGLLYALDCIADDVTMKMCYEAIGSGSGSPSYYFGLKKPANAIAVKYTRRDVQADWTLADGVQVLGGGLDNLPTALEDLKTGRVPNTKRLIVPLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NAE3</accession>
    <name>A0AAE0NAE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family T4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_276866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NAE3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="441" mass="46907" checksum="9E8245A85DBAE161" modified="2024-05-29" version="1">MSSTTTTTTVPATKDDDARGGRRRIRELLPGLHLGRFQPGPLNSLTDVPGVLVHTESIHLPAADADADADGGGKAAAAGGAVNTGVTTILPRRDFFHHACYAGLFRFNGSGELTGSHWIEETGLLHSPVVLTNSFAVGAAYQGIYEHTIREQSDERGRVGWFLLPVVGETFDGFLNDISRFAVRPEHVVRGIDRASAEAVPEGNTGGGTGMVCHFWKGGTGCSSRVIPGFGGGGGEREEEKTYTVAALVQANYGKPDALRIGGVAVGRVLQREADRAAAEQQDARKKAAMEELASEKNRKDGSIIVILATDAPLHPLQLQRVAKRATSGLSRVGGVGHNPSGDIFLAFSTASRIPVQTVTASKRSVDPWKPTPLDVQVLDDNTINSIFEAAADATEEAIYNALCMAETMEGVDGRVIDALPLQKVKDLVEKYGYLSELDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ND26</accession>
    <name>A0AAE0ND26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_548151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ND26"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="80"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="345" mass="38040" checksum="B2E242F596F314D1" modified="2024-05-29" version="1">MGCSFASDENAAEMGLTQGPSSSSHQGIALTSIEKTLSRGIESSAADSQSCVSRSSINVDEFMLKNCRYGDDYEKHPVGWPRLAAIQQQFSNADIFRSFDYIGLRLILHAAARVAFLEDKLAGFDNDQSTTPLRSLTESQTRPPGHSHVNNDYDTLMADLKEAYLEHTTLLCKYRDLRQLHPVPRPHYRDMLRCMIEEGKLDRDAYGWMKSPDEFVSISEPPHRLMLWLLYSTFGKWLMKKAVSQGSTSGGSSSRFLRQDFLGLVARLTMAITGVLVVSIPLGILYLGGLNNPRSFGAIVGFAIMFTIGMVITQEVDTHKVLFGVCGFMAVLVTVAGQRVPAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGJ9</accession>
    <name>A0AAE0NGJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_450478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGJ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="516" mass="58501" checksum="A4BDF37138EA8DE7" modified="2024-05-29" version="1">MDPSYTSTSPKNSRGSENEQQSEPKPSQPTITSARPRGRPRKYGQQPVQSSSRGRQPNNCQPSSSKAPPHEPSPAHQAKRQRVSEKPATDAGSDSDDSDDDEEIGQSPGDFSHHSGATSQIHPEDDGVRKGDMKIPNGLQKVMSRDADNLPNLIAKTRKWSRENELHGKRLDAFMKRFVVPVQYDADWTTADEVEFDDNWGEDPVAAVRVNYGGTGKHLIRLWKFTYRFLNCSPFEIVSPEFLLEFDTTENGLMDIDGIHMKMPRWSAEFMKRLRTLVVHPFFDGDIAMLATAIQYTVICRTNDARRWRVRILPQEQGFLHMLCEAMDNPVHKNQPVPEVHKAVKQIQAQGSKRGLSKVMDLIEKVAWNSDVPPKMGALTPCYFVRSEDLGNLTTALDSLITFGVPMYMPAETIEKWAAVSLVQYGFPSGPNIDWAVTAVLKDQQRKLLRDAERRQKSLTANLEANDERHEFQAHEAIALMQLRLPGPWDHLLFPFHEALDPQIRWQPPIFGLHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGP8</accession>
    <name>A0AAE0NGP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLL-like beta propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_396530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041992139" description="PLL-like beta propeller domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PLL-like beta propeller" evidence="3">
        <location>
            <begin position="122"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="433" mass="47118" checksum="F5F9B417A6B5AC3C" modified="2024-05-29" version="1">MLIPLIFLSLGQGALSLPQPNAQAAPFQKFQVEPRASSVDWNAPRTDHGGFLAKRSGLHSEEFFNNPPRSILDVEPSSSFQAAALEEESSNSSSSKRATSGRWENLSGTAIGHPCPVSWGGQRMDLYQMGKDKRCQHKSRDSWTATSKWGAWEDMAGSFDAPPAACSRKQDNTHLFGKGTDGQCWHRSYSSGTWGAWQSMGGAVAHYPAACSWGKDHAAVYVSSTDGQCWHRRYDETPKAAGWNSWENIGGYLDGPPKAVTWGQDHTSIVCKGQDGQAWHKPYGISSTSKAWGEWENLGGSLDGPPAACAWNGRMDIFAKGTDGACWHKTLKNTTVTTLPKWGSWENMGGKLKEGTPPDVVAVDGGKKMEVYITGDDSAMFRKVWDSTTDKWTDSWEAMGGSVDSKPTAVTWDNGKVDVFGTGADGSIKRCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGV1</accession>
    <name>A0AAE0NGV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_495081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="694" mass="75414" checksum="E56E1812C3707724" modified="2024-05-29" version="1">MAYSMLKIFPLNMVQKPPFSVEAPGYEHVEGETIPRRHPKAKDGLWERPHPGINTTFDLLKRSAEQYGNEPAIGSRDLIKTHKETKKVPKVVDGEVVEVDKEWTYFELSDYKYLTYQEYFTLILQVGAGLRKLGLSPKDRVHMFATTTPQWLGMSHACSSQSITIVTAYDTLGESGVEHSLVQSRANAIFVDPHLFKTITNPIKKASSVKVLIYNNFSHATIPDAQIKAFKVSHPDLTVISFEELRALGEENPTPPVLPTPEQTYCIMYTSGSTGPPKGVPVSHGGFVAAVAGLYTVMAESVSHRECVLAYLPLAHIFELVLENAVVFIGGTLGYANPRTLADSSMRNCAGDMRAFKPTVMVGVPQVWEQIRKGVEAKVSSGGALTRAVFWGAYNIKSFLVSKGLPGSTLLDGLVFGKVRTMTGGRLRFIVNGASGISSGTLRFLSMVVAPMLSGYGLTETCGNGALGSPLQWTSEAIGAMPGAIEMKLVSIPELNYYANTTPPQGEILVRGACVCTSYYENPEETAKAVTPDGWFRTGDIGEFDANGHVRVIDRVKNLVKLQGGEYIALEKLEAVYRGAPSVLNLMVHGDSSAPRPIAVVAANEKVLAEKAAELGVDEHNMHHDPKVRAAVLKELQAAAKRAGFGPMETVTGVILVDEEWTPVNGMVTATQKINRRAVRDKHSKEIADCVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH45</accession>
    <name>A0AAE0NH45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_201725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH45"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="364" mass="39436" checksum="08CEE464E9A7CCA5" modified="2024-05-29" version="1">MAIREDLVASAANFLKDPQVASSPIETRIAFLQAKNLTQEEVSAALARVGPETAPPPQQAYPPQGAAPSQAQAQAQAQPYYGQYPPHYPPYAWPQPPQEPPRRDWRDWFIMATVVGGVSYGLFNLGKRYIYPLVAPPTPERLELDKKSIDEQFEKTFALVDQLAKDTEALKAAEQERTQRLDSALGELETVINDLKSANRHRDNEAQRVRDDLQNLKESIPRAMDNQKELTDTRLREVNTDLKSLKTLITQRMNLATAPSPSGGNYLRQTNSNATPAAVPVTTGNENKNTSNSKAASGADQPKPESSSFGRSSPFSSGMSQKASIPAWQLMASKNAASTAAAAATAPVNGTDSGSDTQEATGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA0</accession>
    <name>A0AAE0NHA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_205431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1149" mass="124592" checksum="BDB6F51869B64873" modified="2024-05-29" version="1">MQVVPSLVGSGTAVAAAAAGLVFGQPPDSDNTPSPGSVRRKLAPDFYDPPRVQHDSSRPGTSTAVPETSPLEEFPYSSFRHLNNAASGPHTSYPPITTRQRPLNIQVQASNGAGRRHSFIRQGDLASRPIAESSNRDSVSSRDSWYKRLSAIRPLSQHGGSPRSSMGPESPSLNFSQASGVPMLGAESPASQTVPNKLVKRTTSGQHGTPETPLVRRGSRSQMLTLRRPATSHQRSATLQQFQNQGGFSGPPLPDAKYSFDQPPALPRELLLASPQTDTATEREASGKWTSFFHAELRPGPTKLVGRGSTGSSAANSPNNLTLPRKRVSSQPGGASRAYLTKAHWITGAAIPTEAVEAPVNRPEPQRESSSQDASDPSSSTDSTPSRRARRSISMHFGSPGSWISKTGSLRRGSRRGTVDAKSGGGRNVSAPAGATQNLGQPVVKPTLEEIFTPPDLRQHLEPDLAKSAAHLQARKRNSSSPLPPLSRLSSFNVDVARLGLSSSSSTAAPRHQLHTPVNYMSNSQTFSGYPHSRGPSGERASTLASSDAEIRDGISGDDEDTDFRSDGMFDSFRTVASSSRMRAVETPLESMFDESPPSTASNSKTKRLSIQEILGRSWDGETKITEEDESLPTPIRAGHLAEPIDFRRQDQDDDDGFDQFDDASPGLSLANRDFGRLSLDDDDDDDWARDDENTLSNHLSPPSSANNSRRVSPTFRHVLVNMSRNGSPDLQRDGSGDRPRSNIFDWCEPPSHDRVEADGHSPRPKTVHGKQELDLRGGRSASRKGPSAAHHVRSQSVPVVPDPSDGSKPPPKFGTWGLGTKTASEDWDDDFDFDETAADMTGGGKDSGTSFSMVVPASIQATQPTVKAHSGQIRELSLLVNDLKRLCRHGRDLDMLHGALAAKWKEAENIIALASPDEDGAEELESVPPPTDLDLSRIDERFLADGFDGSVPDQVDDPFESPEPEMSRTSVVRERQVARRRSVFSPDDDIFGGNWPLTDEVVKPARPRTPEPPMNPNRNSAVIATVIEAMQQQRSTDPVRSTSPSKPWDSKLFFDTNSLQELVKRAGQLRDSLSDAVRRAELITQSPAGTPRRERHPRHNHDGSPAFTRVFTDPASSPPKRLPKSHSTNSVLSRTSVDSPRMQMMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA6</accession>
    <name>A0AAE0NHA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_207966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042080767" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="32"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3381543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="555" mass="61595" checksum="384D967B9BE07ABE" modified="2024-05-29" version="1">MRFLLGSTRRGGVAAAVLLGLLACCCQVAVAAGPQLRREEQSSSSSSYAPSYLVNKARANAVKQSFQISWNGYYKYAFPHDSLRPVTNSFADDRNGWGASAVDAFSTALVMKNWDVVNQILEYVPTINFDNTSTEISLFETTIRYLGGLLSAYDLMTGPLAVYGSGDTSNVTEVLRQAKRLADNLKVAFDTPSGVPDNMLRFGPPRKVGQTSNGIATIGTLVLEWTRLSDLTGNPEYGVLAQKAESYLLQPKNPALGEPFPGLLGTNVDIKTGLFLDGNGGWGGGDDSFYEYLIKMYLYDPIRFHEYGERWVTAVDSSIKYLVSHPTTRPDLTFLAMWNNRTLQFVSEHLACFNGGNFILGGLTLNNPAYIQFGLELADACHKTYISTATGIGPEIFNWQDSRLPLNATNNPGAPRDQAAFYNVSGFWIGNGQYVLRPEAIESFYYAYRATGNPKYQEWAWQAFKAVNATCRVGSGYSSIDNVNKPEGGGFTNFQESFWFAEVLKYSYLIFAEDDPWQVKADHTNQFVYNTECHPIRIASGYERTWNSKRKKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNF1</accession>
    <name>A0AAE0NNF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_170077</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="141"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="327"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="770"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3384767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1181" mass="134631" checksum="0A4D6836714CF31B" modified="2024-05-29" version="1">MPGRTINNIGAESSRKRSRLVPPHDSDDDDIIDVRQASSSLRGDSSKRVRLSNDESNKGGHRFGRHSTPDTSDDAEEPSNGGGEPNSPESPAKTQYELMRDGNFEHLQHQAADDQRATQRLRFRPNLLGDNAIADNGIIESITCVNFMCHQRLHCELGPLLNFIVGENGSGKSAILTAITLCLGGKASSTNRGGSLKSFVKEGCERGFLSVKIKNQGQDAYRHDVYGDSIVVERHFSKTGSSGFKVKTYMGQIISTKKQEVDEIVEYYALQVDNPLNVLSQDNARQFLNASTKTQKYKFFIEGVQLQQLDNDYRLISESLEQMVAKVPDQEERVKHAKADLEKANQLKEAFEGNRKTRVKYRTVRRQMVWAQVEEQEKELERRDDVLKAARTRVADAERLVREKQQAFEIASDKVTGSEEAVQNIREEEGEKAKLVEEADDVFKKLRKELEHLHHEEREAHQQLKAASDSIADLKKKIDAEAKRLEDANGEAHTLKENELKEAMAKIENLTKEISDNKTRELTLKNGVDDAKKALGAISDELQRKKEEISAAQVNIQQLQEKQNTLYSGYEPKVPDLVRMIGRDNSFENKPIGPLGAHIQLLKPEWSSILEKTLGGNLNAFLVTSKRDQKTLQEMISRFQIRNCPVLIGSRHPINLNGKEPDESFDTILRVLKFDNNMVRDQLIINNMIEQVILIPERLRAEEIMFNGAAPRNVKACLSFHEKKRGEGLRLTRNDASGSISTSPIVPNYSQRPRMKTDSDSQISYRQELLKQMEVEYRAIDSEKRRNQQEAQRCQAELMSLAKERKSLETQLRHARVLAERLESDLDQFDGADGRLRGLQEQLKELEASEHHHGLQYGTLELRRKEKNAVVEKASKELKEAKLKMKDFEARLEKELSKLKRLGDSRRIELTETNEACSSLEITKEELEQAEGKRERQNKHVLEFTEQAEAGFSPRTPIPDNETHLTLKKTYEALGKRLEEQEKKTGMTEEEVNVNLARAKEAYNKVVDDLHSIKAVNTGLRDTLNLRLEKWRKFQRYISSQSRANFIYLLSERGFRGKLLLDHERKALDLQVEPDRTEKRAAGRNTKTLSGGEKSFSSICLLLSIWEAMGSPLRCLDEFDVFMDNVNRAISTNMLITAARRSVNRQYIFITPNAIEGRNTLDRDVKIIRLTDPRQRTLADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNM1</accession>
    <name>A0AAE0NNM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_494102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="777" mass="85326" checksum="6C54F1BCEF2204CB" modified="2024-05-29" version="1">MLSRRIARASPFRLATALPARPLPAIQLRTYIPDSMTGQGGVLERKYPKSDYAGLSEAQDPEMNGGYVNPPRIKRQFRDPHGDWWDKQERRNYGEPVHEDHDMMGMFTPYEYTWVKPGKGLLQIGAFITAVFTLAYGISLVYPDRRSYPREFEGGLVKELGGAGAPRRALLSNLPNTSTAFPGTRPSTMRYEDWDVILFPAGRDSKVPFKEFKVGCHVVPDVELSHIYGSMGMPVMTCFVPSLAAGAPFQISIHSWKNPEISQFTRTYSKHADLVKFEARIMLDGRMVASTAFDRKVNGPHLITSTFEFTKTGELERLKFPYFRRELLFQSHWNPGDDIGRIKIVISEGFPRDSLSVPIERVKNVVTFSFQHAPLETLESTGIAWPNPTMWRRPPYAPSMPVPTFHPADGPDSHAHSPRRRSLLLRNSKSQGFPAPMVTGNIFEPAPQATTGFGGNPVLQVPYLPRNNTGSGSSLSYPDPFTESAAYMEWINSVTNAQSSDSVGGKTPWPVNMRSSRKQSSSDTNMPDFVHSHVGDPMHISGPSLEDDPMSLKVPTNTPTAGPLDEHQSVQYPVCSHSMGLPPDLATSLTHSLLNQPFPLPIQPHNIPLPSSEVKSRKENRQLAVGESNALSGLSTPHIDHVEDRKFSQSGFNLGSVESGHVLAGPSENAECASPANLQSATRTNSVSRNGTAADFGSNITNFSAGPLNNMGDTTGNTLNLGFGSNSNNNNTSGSGMKRTRTFTPVSAKVIDEEDEPRRASPHVRIAGFGADMINDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPL3</accession>
    <name>A0AAE0NPL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_472800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPL3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="41048" checksum="83CCA935471E6EF7" modified="2024-05-29" version="1">MPVPQETPTGAAEFIANLTLRTFTSSRIAGNFAWDLLDAYAVPVFESHAPRVMQESERFELVSSLYGPGAFICWLCVIASVLVSWTLNPVCRRKDSISNDYMAALTLPLIAAVHFFHQNITYEGPDGDRRPLTKWYPEAVKFGAAVEAPMAVCEVFTVLGLALFGIAAWNRLPRRATAALLVTQVCASTGLALLVLYTAAHPRTFNYYRCYNANFAVSAAILGSLMSLHGGAYFMETATGHIILRLLVPTHLRGTWGGRNRRDTDSSWETWRRQPGRISGALAAGSVAILGFVTLYIKYHVNQAYKPMYTRTMGLKFIPHSSASAGDLDQVAAILGGVVTLGLSIRDSIRERRRERVASAWAARETALRVWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPS8</accession>
    <name>A0AAE0NPS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_560080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPS8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="128" mass="14374" checksum="3545834D20E77246" modified="2024-05-29" version="1">MASVQAQLQGLSEEFTNLQKELQEHVQSRQKLEAQKQENLGVQKEFAKLKDDETIYKLIGPVLLKQDRVDAEGTVNGRLEFISKEITRLEGQIKETQTKIERKKGDIIQLQTSAQAAAGAQQQQKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQA3</accession>
    <name>A0AAE0NQA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_522914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQA3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="192" mass="20754" checksum="2AE1BC6722C39AE2" modified="2024-05-29" version="1">MANELRRRGPRVYPAYPIRPPVRRDPCEKWAHRMEQVRLVLGVLFAQVAGIILALDAPKLYEGLVMVAEVRFHHGMAVYQKGEGKGEGVSAGVDEGAGGGMDDRQGSKPPGRGGSSAYGGDVRARLATSPRALGSAATEKIYAIRVLITVLAINTPATSRNTSRNRSMVIELLDLLNQTGESQRMTTVHSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQC7</accession>
    <name>A0AAE0NQC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_510465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQC7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042119671" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="14887" checksum="8D29D96583DE03E0" modified="2024-05-29" version="1">MYLIKFIIGFALAFSALALPQSAADAVVVDETIIAPSAVELPGSSQKRDEPKELFARDRLCRINGSGNVNCRSCPSTQCSAPYYVVGGTYYNFDCAAQGECVTINGVTNCIWDKEVTTGCYVSAYYTDSGCTVGNLGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQI4</accession>
    <name>A0AAE0NQI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_187753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQI4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041918771" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12775" checksum="64C1C91D9BC4386A" modified="2024-05-29" version="1">MHFDGPRAWESLFASWWLPVLTRYSIADRISSVSRVAEAKEEDREWCGPLSFAYQPTKSYGHPQNNVQTAPAPHKPPVTSVGLVTRIFLCRNGYGYFHPNSAASHLARSTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQQ8</accession>
    <name>A0AAE0NQQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_189459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249425" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="20"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="271"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="512" mass="56789" checksum="040E490917071D23" modified="2024-05-29" version="1">MRATTVCAALTLCWSIGAAHPFGLHDVSRSQKPVGGTTLEPPSLPRPSVRQHAKNADICVAGTRQYTGSVPVSPEKDLFFWFFESRNDPANSPVIVWLNGGPGGSSMFGLFEEIGPCQTNEHFNGTVFNKHSWTEFANVVFIDQPAGVGFSTFKKGHDGGPDNLLEAAQDFSQFLTVFFHEIFPEAADNDFHIAGESFAGRYIPGFTHYINQRQQLGGDAGTRRAVPPIQSIILVDAVVDAFGFYISGHYDHFCGVDKNGKKRMPENGFNETACDSLEKEIPECERLATLCGSTYDPVVCETAVSYCDDKVGKWFNGDVYPGGRDPYDDRKKCGDNPPICEPFNGTSSYAGYLNSPHVKEELGFSDDFVYAGINDDISKRWEKSREAWVPTTRELTSILDTTPTRVLVLNGNNDIGVNTEAQNRIYDRLPWSRQAAFRSHEYTNWQWPDESGKPIKGGKIKTADDLEVKNKLAFVSVDEAGHASVGDQQEALTWLIKCWTDAKHQKDERCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR03</accession>
    <name>A0AAE0NR03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_473869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="606" mass="68213" checksum="E6525CBD4F0659F3" modified="2024-05-29" version="1">METSFNSSDDQVFTRRRGGFMNESNPLWECMPSTLEFTRKSLKSCQAAYAYNFLVNRGAVFGGNATEILGAGLYSLNATLPGKFAPGSITDAEAVEYVDVLYTRPLFSKYSTIQYNVLENCASSGEIGFAPGFLNYTLDCTVTTSIYRTYFLDDYQRTAPLEYDDVLELVKASFPDRDALPVLSNNTLFNLFNNSRNASDIFGRPETEFLVTYLRLATDTCALDACRALNYAGNGDMAGTGVMAAYSSIAALSTSALVIVLVYKFLPRWRSHYVIQAAFRALEAFRGTMMFFSFMTAIAGFVLMSQTKSYYETKANLLISTFCADAVMSLRLLTRYDNNVNQYLGLSRYSSLITLLLLFSLVLYLLITSIWRLSGDKYEDFTCVKIADTGGSWNEIVISLQVGYLFFYISIIIAMSIREFKRYKLPELRRARTHAQAYNNVSDVPNTDTPLPPPPPIKQSRDMERDPLYDFNSFNPINIVFSVLAILLMWTSLLQLQIFRKKSEDLYGESFGDTTSVGYGQIVAMGFCAETVALFFFVVIHEHFKTHAHNQEGPIDPDHGNIVVELNEPREKTALMSEHTSTMTLENDEITEVQPDSVLRRTRTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR38</accession>
    <name>A0AAE0NR38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_494793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="118"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3386178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="627" mass="67514" checksum="89D08BB66A26EF4E" modified="2024-05-29" version="1">MTLSDPDLELNPLGPMHSLAQGSSYTVRGPTPGSSGADRSKAVVKGAMGRFVDTFRRDDDRSINRIEMYVTDADHNNGTTPRTSSVVRDHHGGRYFDLQSANSKTASSLLARELKGRHLQMIAIGGSIGTGLFVASGKALGDGGPASVLLAYTFVGVMLYCTVQALGELAVVFPVAGSFSAFSTRFLDPSWGFAMGWNYALQWVVVLPLEIIAGAVTIGYWNPEINKAIFVTVFLLVIVIINMFGVKGYGEAEFVFAIVKVTAVIGFILLGIVINIGGTPTGGYIGGKYWTDPGAFNNGFKGTCSVFVTAAFAFAGTELVGLAAAETANPRKSLPTAIKQVFWRITIFYVVALTLVGLLVPYNDPRLLGATSIADASASPFVIAIESAGTTILPSIMNGVILVSVISVGNSSVFGSSRTLAALAEQGQAPKILGYVDRNGRPLVAILAASSVGLLAYLSDVQAQSQVFDWLLAISGLSTIFTWASTCLAHIRLRKAWAYHHRSPSDIAFRAQAGVAGSWVGFGFNALILVAQIWVSLDPIDPPGGRTTPRTSRDMAENFFIQCMAVPVILVFYLGHKLWYRTTPVRIEEMDIDTGRRDFGRLGIIKAQEEEERQAWPKWKRIYRVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRV6</accession>
    <name>A0AAE0NRV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_447500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20565" checksum="B889FA5CF4027DE3" modified="2024-05-29" version="1">MPVPLETAAATLTLCPAASPTTIAKTVAASAAITSSITTVITATTTIVSHASPADDQAWAAAAEAISSAKKEKKMKWLVVWVEKEEEEKEEEEEKEEEEKEEEEEKEEEEEKEKEEEEEKEEEKEELAAASLSSPCCSRYSRKLLPPPPLLGMTVPLNWLALAPWLLPIIWAGPRTVYFWGLLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS26</accession>
    <name>A0AAE0NS26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS26"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="15935" checksum="41C741BA508609B8" modified="2024-05-29" version="1">MFSTTLRRLAAQVPKPQLNPEALRPSARLKKVWPPEFSKLSPQEQLRYEKRYKRRLAHLAERPRWNKFVTLAQYFSISFVIVYSILFMDWKNEVQPFDEIREWFWGTLGGIFSTENKWKKREETPEGDRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSB6</accession>
    <name>A0AAE0NSB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_140781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="693" mass="76788" checksum="F52EE951A469C92E" modified="2024-05-29" version="1">MASRRVPRARRQQDIDSVSNMSGETARPGLSQDESAFESLSEQPWRPVPEIPLPTNDGTSYADFSDANIELTVPGSQEVRVMLAIDYGTTHTGLAFMHQTTERQPLFPNDLHVHQDWEGGNTGRKIPSAISYSKTLHGCKQWGNDIDEQHSRVLQWTKLELHPRKPLEELRALKDSLSGLRLLEALQQNEQAGIDNDIPLHITRSPARIVEEFLSRVAREYYLHMRRESPNAIGEGIVPLDMVVTHPAEWPYEAINKTYRAVTAAFDKLMFPTRRNIYLVPEPEACAVFTVQDMIAFPAGNQTLVPGDCFVVCDAGGGTVDLVTYRFNKLEPLEMEKIGTISGGYCGATFIDQAFIKWIESRTNGIGITSKDVGTGGHFVLEPKGTTILKKFEVMKRKFSGTEANTLTLPSNVQLDASVTNGVPGLLPISAEDMRSFFEFSITETIDLLSRHFIETDVTGGRILHIFMSGGMSQNDYVFNRVKKWAKTHNGEISVQRPTDGWTAVVQGAVLSGMGIGANNAVLAQPCPRHFGIMGAEVINPRKHRDPSIKIIQDVVHGGNVTLNQITWLIHKNDLVLPDQPIIATCQMACTYYQDHIANGSITHVIFCATDTDNPPSHSLSKDNNEIAALEIRIDKIPRSACVTITTPGGTAYIEAKMTVKMTVHYSGKFDVNVMCDEQTMASYPEGKHNPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSC5</accession>
    <name>A0AAE0NSC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Starch binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_468463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSC5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042166208" evidence="10">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="286"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3386833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="40792" checksum="17D75DC358B350BE" modified="2024-05-29" version="1">MKSTSVLAVLSAAVSVHGHGYLTIPSSRTRLGAESGIDTCPECTILEPVSSWPNLDVAQVGRSGPCGYNARVSVDYNQPGSSWGTNTVATYTAGQTVDVQWCVDNNGDHGGMFSYRICQNQTLVDKFLTKGYLPTDAEKQEAENCFEAGTLPCTDVTGQSCGYNPDCTQGQACWRNDWFTCNAFQASSRRGCQGVDNNALGSCFTTIAGGYTVTKKIKIPNYSSAHTLLSFKWNSFQTGQIYLSCADIAIGGGGSTGGTTTLATSTKSATATASSASASASASGCATPAATVAVTFAELATTSYGQTIKVAGSISQLGSWNTASAPALSAAKYTTASPLWTYTVSLPAGTTFTYKFINVASSGAVSWESDPNRSFTVPTGCDAAVTVNSSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSM9</accession>
    <name>A0AAE0NSM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_493519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSM9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="492" mass="52954" checksum="E859C6F78845232E" modified="2024-05-29" version="1">MTSATQTTTPTRGLEPNNDRLSEKLQLATAASTTTDEEAAAVPGAGATTTTEATTYQPGDHYRQRWNESPIIIYRFVATNNSFILKGMSDGAVGALVPYIGSYYSISYTVVSLVFLAPFIGYLIASLVNSMVHHYAGQRGVAVAAAGFRLSGLIALVFHPPYAVLPVAMLFVGFGNGLEDSAWNAWVGNMDQANELLGIMHGAYGLGATIGPLIATALVTKGALDWYFYYYVQVGLDVIGMLLLITSFWRATAKEYRDTHQSSNNGGERTTTRHVLRKPLTWLLALFLLGYVGAEVSLGGWIVTFMLNVRHAEPFIAGLSVTFFWLGLTVGRVILGFVTGRIGEKLAITGYLGLCIVLQVLYWVVPSFEASVVFVTFLGFFLGPLFPAAIVSATKLLPNDYHVSAIGFACAFGGGGAALVPFAVGAIAESKGVIVLQPIILAILIFILLMWLCLPGGLRRGGLERARENHEKVGHEIRQGFKWLKAKAGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSN3</accession>
    <name>A0AAE0NSN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_145461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSN3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="24981" checksum="7DA7DEF077B957E5" modified="2024-05-29" version="1">MNKNWNDRADKDLFFTILSVKNIGVISGAEWTTIGNHMRSMGYGFTNEGCRQHFQGLRRASHKSDSGPLIENNPTRKIDPALNPITRRPGPGRGRPRKHPQPQPGSVVPGAVAPGGGSGPVSGAPGVPGAPAAPGVPGIHPAYAAGLSDAGGSQASPGEFQRSAAAADLPLDPQTSAAPAEIAVDPSLELTDEKPPKRPKLASIDDAAAIEDEVVMNALSAHNNPTQLHAYPAEFNYGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSW3</accession>
    <name>A0AAE0NSW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_141793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="575" mass="63496" checksum="81E5692EC94E1705" modified="2024-05-29" version="1">MVYNGKPSRGCLTCRARRIKCDEGKPTCKRCEKSGRECAGYRPDFDIVHRDQTKSTTRRLRMTEAADTSQASGSGSSSHSSRFVFVSVQQPQRAHVHSSGKLRLPGPIRDSTCPSPSPAMPIPVTHRAACHFASNFVLLPLAATDHGFMEYLAPLVGSEPHDSALRHAFNACAFSLLNNRAKADSVDLAKMALKEHTLALGKTHSALRHPPTAKTDAALVAVLLLSMYEYITGFKEPHMLAWRSHIDGAVQIVRDRGRAEMCSTKTGTLLFNAVRNRLISRSLSAGMPLPFGVDWWTSRGGGTRSLAEAAEHFSLRTAQLFGDTSHLLEKTNTHTPEGIASVLEMWKRVNAMDQEIADWLVAIPAEYRAKTLCWIADGPPHALTPLDQLEAFPGSRVDVYPDFVTARAHNSAHVSRLLLAALSIRLAAWLCSPADYRLTPEYQAARVISEAAIADIIASVPYHLGWHTRRGDLFRNVPDMSTFACGRDEPFKALPAMFILWPITTVKNYDMTTDRQRVWAKGRLQFIEDQVGLKYAALVNKFELRFPSMMIRSGGLAAVPGPLEKKGIQGLPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTI8</accession>
    <name>A0AAE0NTI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_521456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTI8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="386" mass="44133" checksum="B06783CD5399C8C5" modified="2024-05-29" version="1">MDRLQISLEFTQRLLSFFDVSPLFLDFIHSFGLRLDEGREGPVIHRCVTTSDGSSSDGLRTECCYNLKYPEKNGRPTGNPWSIRHSAVYLQHDPVRDMNIWIMVQPSKDFERQLMAMISSPRDTVNRGRAIHGAFFQSANRFWKDYIHSLEQKLTTIEHKALFSKVGVACSHDFDLTFRDFQLLKRLHMQLLRGNYLLDMSANAVELFKTRSTDSALDDHDHGMFRDYTEQVRAQKHALERLLHVSDHVSQTLSQILQYRNDEAVQKTSDLIRQHNKSIEELTRMSARDGEAIVELTRKSQQDSRVVKVLTVVASLYLPAAMVASVFNSNLVQTVTPSQEEESANFRISAQFWLFPVFTLALLLVTIVPVAVWMRLNTARGKAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTP5</accession>
    <name>A0AAE0NTP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_469813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTP5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="188" mass="21730" checksum="FBB7F52397FBC602" modified="2024-05-29" version="1">MDNKRKRSSEHLSTVAKRAPRPSSDTSPSSLLAKQYQYKPLENSDIRLITILPAKSIEDDILIRIAHVPLLGPQQHVPTSGMSLRDVARTLPPHWKDGERTVKRMSDIYRLAHRVVVWLGPRTPDSKHALDTLEYLGKQVVVSTNWSRMPAPDAAEPTWYKNRERLPYDQKTWRAIGELLSRDWFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU77</accession>
    <name>A0AAE0NU77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_164513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU77"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="16841" checksum="257163D6FE07293A" modified="2024-05-29" version="1">MNPFCKANKYIPDHVHIMDISDADLAKLKAGFNENETAMASWDLSISDADFKKLKVGFLSQQMEDKWNIITADLGRSGKKSVHISRSWTGIEHYVIVIKPGDGHSGAKIKGIIWKAEQGDRISEEQAKKMAIYLCRALLEGDFESALDFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUE0</accession>
    <name>A0AAE0NUE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_470559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUE0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="240" mass="26536" checksum="A4CC6E16FAAC2070" modified="2024-05-29" version="1">MKPNSSMALLSAFQGLRISHATTSRLSTALQRPLAPRVSPVAPRVRLFSATAARRGSWLEPMINRKKKMMKGRPRVATGGSTKGTTVIWGDYGLRMWDHHRRISAAQLEVAEKAIKTRLRGQKYFLYKRVACNVGVFVSGNEVRMGKGKGSFDHWAARVAVNQVVFEIRGPVHEQVLRDAFRLAGQKLPGQWEFVKKGDPAVVGITKLDGITLEDLKRPRKKLPEVPPVGTSPSSIPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUL5</accession>
    <name>A0AAE0NUL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_470955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUL5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041955181" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="45"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3387809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="27484" checksum="5EE50D98104B248A" modified="2024-05-29" version="1">MMFKSLLFTAALVAAVPLGEELFGRDFDLGSKVDHASESARSLAAGSPEGNGFHSGYFYSFWSDGRGSITYNNLANGSYDAKWNNVGNWVGGKGWNPGGAKTIQYNGTWNAANVNSYLALYGWTKNPLIEYYIVESYGSYNPSSGATKKGSITSDGGTYDIYQTQRVNQPSIVGKATFYQFWSVRTSKRVGGQISTGNHFDAWTKSGLKLGAHDYMILATEGYQSSGSSAITVSEVGKTGVPYPDEPDSRKPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXR0</accession>
    <name>A0AAE0NXR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXR0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="31329" checksum="DBBC796C8A66E7ED" modified="2024-05-29" version="1">MSGAQKTLGIINIVLEAATVICEIWSMIRPASTLIPVISQFLAIAVVVVGVLMLIFGATEHQKTPGEAFVLRMQASDGWVHNLRDPPAPLLKATMSAFEGIKGSLMSFTINEDNAQTIRFSEAAKDEPGKEESKNTINSLQVSFFAGSDTSNLFSNGASGSSATVAWDIKLLSPNGTSLKSRGYDIRVKAAPENTGAPPTIGPNQRFVFTISGTLGGEAGTAVLKVVERRPGPGCLGGEEDDRREQFALPLNLHVANLKFASSAHINFTSCFEHPTYNEWVDLFSLSREWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXZ7</accession>
    <name>A0AAE0NXZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_537877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXZ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038193" evidence="2">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="39019" checksum="44EA1EF11694657C" modified="2024-05-29" version="1">MTRIFVALLAAAAAMQQAVAAPVAQGAEVAAAPKPPHPSGSRAPPHPTGAPKPRPTPSRAPPAPRPTISRTPPHRPTLTRLPPRPTLTRVPGNPRRGPEDTIIEVRAEEQDEPCDDDEKKPSKAPTPTKAPKPSKAPKPTKAPKPSKAPKPSHSKAPIPPKPTKAPTPPKPTKGPVPSKPTKAPPLPTLTRLPGGPRRGPEDDVIEARAEEEKEKPSKVPKPSKGPKPTKAPKPSHTKGPAPPKPTKVPAPPKPTKAPLPPKPTGGPKPLPSLTRLPPPRFSIGAVEARAEEDKEKPKPSKGPKPSKAPKPTYTKGPAPPKPTKGPAPPKPTKGPAPPKPTKGPAPPKPTGGPKPLPSLTRLPPPRFSIGAVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYB9</accession>
    <name>A0AAE0NYB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_428441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYB9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042036962" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53155" checksum="A7BAB2DF72CE5281" modified="2024-05-29" version="1">MALIYVALGAVLVSATAVHAQANANCTTNSFTVPSWYVEEFKKGGPGSDVTFELLNRATNVSVELQCDAQDTWSNCTTVGSSDPFLQASVLVKSATASVQVQQSWSCSDRDATKPLEFTASGSATIPLVAGGAGQKSANPIDLIKASLHAPVSITPAYADGPTGHSNPGCASKTPTWTLGTVIFLNETGDGDKATESQSIQFQVTNVATGQVAGCLMYFAAGAEDPAVHMTCGGEFDLRRRSRYNVVTEAVFYPRSWRFSISQTWFCDDADAARPVSISATGNATLALNCTKDSTTTTACQAASITVAGNVVSEQALPPYSIEDPLPAPDGCTISSIVAPSWTLSNFEVDKNEANTTGGHDHGHTRRDIDNGPSASISFNMKLNTKAVNYDYPVFVNHNDVQLADAEAWYPCSFGPGEVPIAPKSCSFQYKEATSTLTIKVDWVCIDIDEAHPVQFSGTATTTVPKLDCVSQSSGVQICTAGDDYSWEAQVANVTWKAAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYL2</accession>
    <name>A0AAE0NYL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_538078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYL2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="143" mass="16154" checksum="0E0C197F1CEFA3F4" modified="2024-05-29" version="1">MTDLVEVIRPAAVAIALTNDLLSYKRESPDAEDSGQSHVFNLVWVLMQLRAGMTAEEAKSTYREIIRNNVAEYLDASKAAKTLGTGTYSVDFVRFLDEWHHFPGGTIVWHAFAPRYHHCETLSEGQLDWMTNGIPARMLERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYT1</accession>
    <name>A0AAE0NYT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_108689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYT1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="76"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3390222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="435" mass="46748" checksum="B1B19FC1CD71F206" modified="2024-05-29" version="1">MAPFNLESCARPNILALEPYRCARDDYKDDGSNILLDANENAFGPPIPGNYLPRDATTNGTTNGTGTSAGGPQIDFLSLHRYPDPHQLELKQLLCNLRTTHAHTTKTLTPDNLFVGVGSDEAIDALLRCFCVPGRDRIVVCPPTYGMYSVSAHVNDVGLVKVPLLSAPTFAVDTDAVCAALSDDSNHVKLVYLCSPGNPTGALLAKEDVQRILEHPTWNGVVVLDEAYIDFAPDEASLAEWATEWPNLVVMQTLSKGFGMAGIRLGAVFASPAIAGLLNNMKAPYNIPSPTSALATYALSANGLAITRGNKARILDQRDRLLVELPRIPGVGRLRGGVCSNFLLFEMLDAQGRPDNATALAVYERLAETKGVVVRFRGKEHGCLGCLRITIGTKEEVTRFLEALELTLAEVRGAAAALPAEEEEKKETIANSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYX1</accession>
    <name>A0AAE0NYX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_519344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="24822" checksum="4D296F78E6928E3E" modified="2024-05-29" version="1">MVLKSCLVIFGIKAKGINGSFMLYEGPCESSRRLNLLLHLLLNAISTGIIASSHYFKQVLVSPTQPEIDKAQLHRLLAQHWRSLADELDASAASSFSGVLLLVATVCVLLKVTFYLAALMVLRGPSPIVTLDDAIESFLVSPDPSTENMVNILDKPSTANLAGGRSVTAAAPIDVPQTNPILYLSEPLNYLTLYLWTSFTRYLSLAEDWRAVSDSVTYCKDFRPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ17</accession>
    <name>A0AAE0NZ17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_465310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01303">
        <property type="entry name" value="GDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="82"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="475" mass="51400" checksum="5E264F2682195F71" modified="2024-05-29" version="1">MATPSKKDQLFLGSFIHSTKLDELTYLHNAAVFVDAQGKIVHVERDCDEQRAREALVPRLGWGAGEDELVVVRGGGTGEFFFPGFVDTHLHASQYPNVGIFGKSTLLDWLNTYTFPLEASLSDQAKARKVYSRVIRKTLSHGTTCAAYYATVDVPSTNLLADLCLSYGQRALVGRVCMDQLAPSYYRDESPAASLAATRESIAYIESIDPSRSLIRPVLTPRFAPSCSAPLMRGLGDLAAEMPHLPIQTHISENKNEIALVAELFPKASTGAADDSYAGVYDAFGLLTDRTILAHGVHLSESEATLIASRKAKVSHCPCSNSAITSGAARVRWLLEKGVVCGLGTDMSGGYSPSVLEAARLAALVSRHVAMGGDEKAKLSVEEVLYLATRGGAEVVGLEDRVGGFEVGMDWDAQLVGLGVVDPLGEGVVDDQEDGNVDVFGWETWPDLVAKWVYNGDDRNTKKVWVKGRLVHERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0H5</accession>
    <name>A0AAE0P0H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_131774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0H5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51808" checksum="EEC55C7DD112274D" modified="2024-05-29" version="1">MSDSETAPAVAANTKPVKPDADLFNEQLGKAEKEFQDAMTRYNAIKAKIDLAAPSKNKETQTPTQKRRQELIAQANEIRQQQAGGKNARTAKLDQIKRIDEQVRSRIAEQKAARGKLPYNSADDVERRIQELEKEVNGGMMKLVDEKKALAKIKEIKDSMEDPEAKALSEKYNKIQAELDTIKAEQDEVFKNLSSLRDERTKLQAEQSEKYQAIKKLKDEYYQAKKAHAFWEREQRDKIRERQAAERERIAKERKMERAQKLLEAASDPAYLEEIRRASSLLHFFDPSAAPAEKAPLLADKGLGAQAQRKVDDAGIKGVVLKRKEDRDDEYLPATKGKKKGGKKAAPSAAAAKGYSCPPVVMEDCAFMGIEPPMSAADVPTVIEKVKAKLETWKADQAEQTHKNIEKAKKEIERLEAEEAGEAPSSPISVNGKKADEDKAVAEVTEGVKDVSVEETKTEEGPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P446</accession>
    <name>A0AAE0P446_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_530396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P446"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="35510" checksum="EE4CC1A0D25055E6" modified="2024-05-29" version="1">MHFPSQTLLSPLVWLQLETLFSVSRTATPPGQLSESSKLVVIGAADLIGIVLFVLLILWGKEKGFWLNNLSNWNWKFWKKKTPKPANTVELQEVVVPPAGRGNGRTSTATGAAGSAGGNSTIKPARLPPAADLSRWSRRPTSPPNPVRITNPAPAINPATGRWYSPPHSPPAAGAVSPPSKTAEGIDLDDTPEWQDAEARAREERAWNWDRQRRVRFSDNLEEVMSGAILTGNPPGERERQTVAPPNSDLSDTVRGTSRLPRQPSHLLRQRPSLRPRIILAEHHGIRLLLLNRSLSSKSSRRRDRWPSRVIRHRRHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4A8</accession>
    <name>A0AAE0P4A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_456961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4A8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3392957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="528" mass="57765" checksum="07EE3C1F3F59BC9C" modified="2024-05-29" version="1">MFSCLDTSIVSTALYTISRDFDNYQDAPWAILGYLLTYMSFAVGFSKLSDIYGRRNLLAVAWVLFSGFSIWCALATSMQQLIVARALQGIGGSGLYSLAQVCLVEQGPHRPEIVGALVGITLSISYVLGPLLGGAISGWTWRGVFWINVPFGVLALIGIYTLWPEERRKKYDGWTAISKIDFFGNMLLILASILLVYAIQEGGSFVWKWSSPVIIWSLVVSGVSWILLAMWEYYLFYGDSKTVQPIFPLRLAMGRVYLSSLLVTFITGFVYISLVIKIPERLHIISNNDALGAGINLLPMLGPCAFGSFMGGLISKKKNLTSQTLIVGSILQLIGIGLIYNVTSDTGDHSDEKLQYFLGCTAIYGLGVGLCFAASTIIAAIEARHEDFAAAQGAVAQARVFGGAIGLAICTVIFNEMLNRELGPRSGSHISEQLLDKINRSPMNKDTWSEMSKDPLKIIEYRQAYRTAFNGEMLTMTIIAAVGFVLSLGTYKSNPPLVTETMAQHKENASRASDTELASTSSIRSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4H0</accession>
    <name>A0AAE0P4H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_530324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="33234" checksum="46F270522AA36D7F" modified="2024-05-29" version="1">MASYCARLSGRRMTTARTTRIGYCRAALTTSFLLGWEEEDEQTLYRSFKLWKSWSDNLDFADFYLKKFPKVVTSIDDLDTQDARRVRMVRDVAMRWGWDILFAQFYGSWYGEDVSSPNRGPIAAGAMTFLDGAPPRGIRDLSDFGSYWHFREHLGEIEQLITAVHDIAGNPVDAAAAYRRIFSTLTLMRNKPSEWPANTAFGLNKSGAGTLYAELFKRACTPQSSDCDASPNVEFSPGLGAISWRTMRFLFLPFKIASSISFVRTAKSCIGFKWRTTWYLSTIRTFFYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4N9</accession>
    <name>A0AAE0P4N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_491302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4N9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="542" mass="62259" checksum="CC6D04405799361B" modified="2024-05-29" version="1">METATPILRLSPQIRHRIQFENIKFISHSNDSAPSRCVHGLLLCYRTIYAEVSTLVYSADIFVLHYWPNRSLQPLLALTAASLAALTTLKIVLNENSCHPGATEEGDAGCCDQDWFTGPSYSRDSKSLEDEIRERCDRDHTRCHRPPLNRNDLRATASSPTALVCDLVCGDPDVVELTVAPLRLLQPLKNCHLRLCRTRNFELQQVAKQVVQDAVLWPWHHAATPLPVFGSIAASTSAPTPSALQKRCSWLLDLPSELRFHILQYTDLVTPEKEVIWGRQDGAHYHESVAHCSTDTFERCDSMDCPPDIHSGCRLRRCWAKHTAVSSTCRCWAPPVSLFMICRTLYEDAQAVFFSCNRFIIHDYKSNQPFKAPPEDGDYPEERLAASQFIREALIFPAYSSRRWPRHDHPAIKDWSSTIDWLKDKINALGLTIRIVMAEPCDGEWPRLRRDMTEAQGREVIAGYAYIIRPLRLLGGGSDDGERGLRAFYAQLELPWKWIPAFKHNWDNPWRTVMGSRYTRLYRTDVVEPRERLWKEWYARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4P7</accession>
    <name>A0AAE0P4P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_406620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28322" checksum="8A93B4E0D8E15B72" modified="2024-05-29" version="1">MAAPKDAEPEIVLYDLACTKGVCFSPVVWRIRLMLNYKRVPYKTVFLEFPDIGPTLEGFGLVPGESPSGVKLKHTVPAIHHLPSNTYLMDSVPIAQFLESHYLDPAVPLTSPLAREIEEKGRRAIGPVFGASVMPREINILSPRSQEYFRRTREERLCRPLEELLNTPGKEDQSWDDADSDLRALSELLQTNKADGPFALGTKPSYVDFFIAASLQSARVVDEGVFQRVYKYQGFRDIYEACQPWMERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P578</accession>
    <name>A0AAE0P578_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="10">HMG-CoA reductase</shortName>
            <ecNumber evidence="10">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_387944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P578"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="243"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1190" mass="128323" checksum="DDE13CF7CB7A928E" modified="2024-05-29" version="1">MIAANLLPSRFRGEQPASQPASPSWLNKKTTPLLQVLAKLTSSNPIHTIVIVALLASTTYIGLLEDSLFDATRSVRKAEWSSLVEGSRRLRAGPDTAWNWQNSDADVPLAQNVDHLALLTLVFPESLSTDTTKAPPMVSAVPIPQNLSIKSLPSTSNSFTTYAQDSALAFAVPYSQASEFLTIAQEIPNGIPTQETRETEHGREKKMWIMKAARVQTRSSIARWVHNAWTEFTDLLKNAETLDIVIMALGYISMHLTFVSLFLSMRRMGSNFWLATTVLFSSVFAFLFGLFVTTKLGVPVSMVLLSEGLPFLVVTIGFEKNIVLTRAVLSHAIEHRRPPGSPGKAPKRAENASNVIQSAIHMAIKEKGFDIVKDYAIEVCILIVGAASGVQGGLQQFCFLAAWILFFDCILLFSFYTAILCIKLEINRIKRHVEMRRALEDDGISRRVAENVAQSNDWPRADGKDQPGTTIFGRHLKSAHIPKFKVLMVSGFFLINALNLCTIPFRSANSISSISSWARGLGGVVAPPPVDPFKVASNGLDIILAAAKADGRETVVTVLTPIRYELEFPSVHYDLPQKAGKDTTDSLGELGYGVGGRMVGGILKSLEDPILSKWILVALALSLALNTHLLNAARWGIKDPNAPDHPIDPKELAEAEKFNGTESATLPLGEYMKPTTPAPVIPPLTPALTDDEADIQMKVAKPAPTPTPQDSLVRRSVEEMEQMLKEKRAHELNDEEVVALSLRGKIPGYALEKTLKDFTRAVKIRRSIISRTKATADLTNLLESSKLPYKDYNWAQVHGACCENVIGFMPIPVGVAGPLVIDQMSYFIPMATHEGVLVASTSRGCKAINAGGGAVTVLTNDGMTRGPCVSFETLERAGAAKLWLDSEKGQVAMKRAFDSTSRFARLQTLKTAMSGCNLYLRFSTTTVSMGMNMISKGVEKALSVMQTEEGFADMNIVSLSGNYCTDKKAAAINWINGRGKSVCAEAIIPAEVVKSVLKTDVDTLVQLNIDKNLIGSAMAGSIGGFNAHAANLVAALFLATGQDPAQVVESSNCITIMKNLRGSLQITVSMPSIEVGTLGGGTILDPQGAMLDLLGVRGPHPTNPGENARRLARIVAATVLAGELSLCSALAAGHLVKAHMEHNRSAPPTRTTTPAPSGALTPVALAMTNTVERVASSTGLSAAAIERARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5B1</accession>
    <name>A0AAE0P5B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_443761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5B1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="225"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="33783" checksum="C7B4917B50DA87EC" modified="2024-05-29" version="1">MSEAPILNTGRNEGGSLEVYDGSHNITSHASHGNNLPHAVTPPYQYIKPYEEYDGLHPRQTYQHLQQTQQQQQQQYPPQTHCQQFEMPVAAAAPPPSKIYDDNSSGKGGGSGGDGKGRRVRLVTLVLSCLLVLVIAGLVLVGALLGNKISTLEKSLNEVSSRQQQQQQQQTATAAGASAPSAPNTAAGIVTSGTPTPSRTGASSISSSTTSSEAAAQTTDALVAGYKYIGCYIDTPARILQDGKFLNDTLTNQLCADLCQGKNFVGTGGNGGNQCFCGALLVPPAARGNDFDCNVNCPGRFGQKREICGGDWTLSVWQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5B6</accession>
    <name>A0AAE0P5B6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_21992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5B6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28673" checksum="748381CF64668F48" modified="2024-05-29" version="1">MARKKDKIPDAWDDDDWEAQADRIAKEPEPEPEAPQVPVTRAERLAKHAEDQRKLWESAEAPSEEVNFLPPSNNIPLATAFKPALKLLSRKPAPQGDDDEEDDNKKDQPTPEEVRLRQQREREEKQRRYNEARARIFEDSNLSSGQSSPGNVTPPQSSEGRQSYRGRGRGRGGRGAHNNDNRQDNQSRRLPANQQPGSRELFDPSYSPRAGFNVQRRGGDGSSSTPREEDQIIRTPRGPDGGAGFGFSRRGGTQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5N3</accession>
    <name>A0AAE0P5N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_459398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="334" mass="35673" checksum="53EB17C40C7EDD4D" modified="2024-05-29" version="1">MTRPRRSSAASEESMGDVRDQELGSMYDYLAKIILLGPSGTGKSCLLHRFVKSEWRVLSSQTIGVEFASKIIKVGTGARRKRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVTSHNTFTNLQPFLNDARALASPNLSLLLVGNKLDLAGDGVLINTGQPPPTPSSVSSATSYAGTPIPGSYSSTSGMNIHPGLGSQLKATVAPDGREVSAVEASRWASTVNIPVTMEVSAFSGEGVDEVFGRLARMILTKIELGEIDPDDPMSGIQYGDAGGSWNAGASDGGSIKSSMTADDVGVGGRRRRRPKRGGPPGLREWEEVFTLSGRRRNRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Z2</accession>
    <name>A0AAE0P5Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_30163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Z2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27488" checksum="0D738B71DCDD6515" modified="2024-05-29" version="1">MASNTNVLITGANRGLGLGLLKIYLSRPNHTVIAAVRNPSDSSSQNLKTLPTGKGSTLLVVKIDSASDTDPADAVATLKAVGITHLDIVIANAGIANIYARVEAIDLTKLRHMLEVNTLGPLKLYEAVYPLLKAASEKRGGSPPPQFIGISSTVGTTADAEQTNDYQIATYGVSKAALNHLVRRAMLENEWLNAYVVHPGFVQTDMGNIGAGLLGIEKASLTIEESVAGIVKIFDNVTREKIAGKDGYYQWDGTKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P692</accession>
    <name>A0AAE0P692_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_517229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P692"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="161" mass="17832" checksum="9A060998B7943AC5" modified="2024-05-29" version="1">MRTYDDTFSGQRIYPGKGKLFVRGDSKVFRFQNGKSESLFLQRKNPRRIAWTVLFRRQHRKGISEEVAKKRSRRTVKAQRAIVGASLDVIKERRSLRPEVRSAARLAAIKEAKDKKQESAAAKKAEKAKSAAGAAKGQAAGRVTSKQGSKGAAAKPAIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6E4</accession>
    <name>A0AAE0P6E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-containing amine oxidoreductase-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_39122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6E4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000249">
        <property type="entry name" value="Lysine-specific histone demethylase Aof2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="373"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139818" checksum="48DAC61209D852BE" modified="2024-05-29" version="1">MGTSSRIRSGQVGGIGNGTLKNLKELDSRRSKRASLAASSPATKPVNNSGRSGTTASRVFHTDSESNSEDIAPEIIVWTETMDAMNIDDDSSSGSLSPATEMEDPFTDPDIVQMEIEHNATPPLPRLTPPPPTPTLLIWAPEPELPPEPEQEPESVLEPESKPEPEPVPELESKSVPESNLGLKSTAELEQELEPELVAQQEPKPKEKRQSNSKPQPEPIPEALLESVPESLPEPKQFPDLQQLPEQAPEQKLKLENKPELETELEFKREPGSEPVLQSEPAIEKPVIEQGPSAASSLSAISFVSERSDLSSLPSPSLSSKATTPIDIDSSKEASGPVFRLSQSADTPRRRYDVRPKVSIPPDLPVSEYAMQCIAGAETSRLNPYSLHEEEYLILRDHISHAQVTTYLNIRNGILRLWVRNPQVAVTREEAVGCAKDTRWFDVANVCFDWLVRRGYINFGCVEVRASRKQVNREVPVDAKQKTVVVIGAGMAGLGCARQLEGLFMEYSKKFREKGEMAPRVVVLEGRNRIGGRVYSRAFATIPTEAPEAFRGKRFTAEMGGMIITGFDRGNPLNIIVRGQLSLPYRPLRPDTTLYDSNGKPVDLERDQLVEKLYNDCLDRVSEYKFKQPTSKLIEGNRDLMDEGKDSSAETHKTIRQTEESVAAQPYAPPVSEQNITPQVNLVPVSSDRATGRIHTEPGTPGALKAAYKAKLMGWALKHGVSDDADLDIESATREPNATLGSVTDNVIAQYKDIVDLTAQDYRLMNWHIANLEYSNATNYNQLSLQGWDIDAGNEWEGNHTMVVGGYQSVPRGLMHVPTPLNIRQISPVSRITYASGNSTGAATVECEDGFTIEADYVVNTIPLGVLKHGNVAFNPPLPSWKTDAIQRLGFGVLNKVILVYKEPFWDDDRDIFGLLRNPTNRHSLDQKDYASQRGRFFQWFNVSETSGLPVLLALMAGDAGYDTEQTCNDDLVAEATEMLRNVFGPKVPDPVEAVVTRWASDKFARGSYSSAGPDMKADDYDTMARSIGNLFFAGEHTSGTHPATVHGAYLSGLRAASDVLDALLGPIEVPSPLIIPKETSLSLKRKVANSKDPTKARLEAYEIELWDYIIAQIGLRPIAPTRPAINAYVFYSKAHYEDARKKLEEGRRAGKGKASANEVRVMSAKMWRDTSLEQRKPFMDQADEQKRLYSQALAQFKEHAADWDKKATELKEKYEKEHPCVPTAEELAAIAIALAEKGQRRSRMRVESYAETETSDVEMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S4</accession>
    <name>A0AAE0P6S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_44054</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="179"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3394364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="372" mass="40329" checksum="FFE5E2D996FD0B6C" modified="2024-05-29" version="1">MAPTVLHLRSETKHLEHRSALTPATTAALIKAGYVVNVERSPERIFDDAEFEDAGATLVPEGSWVDAPQDHIIVGLKELEEKEFPLQHVHVQFAHCYKQQAGWETVLARFPRGGGTLLDLEFLIDERGRRVAAFGFHAGFAGAALALEVWAWQLSHNEPFPGVASYPNEDALIANVSKALNSGAEKAGRLPRVIVIGALGRCGSGAVAALRKAGVPEDNIVKWDMAETAVGGPFKEITDSDIFVNCIYLTSKIPNHVNLESLQTPDRKLTVVCDVSADTTSPFNPVPIYTVATTFDSPTVPVDGLKSGPKLSVISIDHLPSLLPREASEAFSYDLLPSLLTLNDFHNSPVWARAEKLFKDKVATLPASALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S8</accession>
    <name>A0AAE0P6S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_460872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="184" mass="20934" checksum="10579E8C6BBCFCFB" modified="2024-05-29" version="1">MSHSLYVSLNILTLNQTALYFLYYTLLIFEDRVGIGCGGLRGGCTVSQVLHLSHRMRLRRSKLQIARGANVIEKKTEYSYSFEGGNFSRDIPNDKSVVNERKYRLTAELKNLRFPDQKRPVFLGLLAPDIRPALTQKAAPIEIEALFLQFNDGTPHHEVLYLLNVIKGLSQVSRRLPAMKISEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6W9</accession>
    <name>A0AAE0P6W9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_461069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6W9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31239" checksum="5449CEF5B34432E2" modified="2024-05-29" version="1">MSDYVWFITGASSGFGEAIAQEALRRGHRVIATARNSSKLTALKEAGASILDLDVTSDDETLAAKLKEANAVYGKITHVANCAGYILEGTIEEASNKEVFDTYNTNVLGTFNIARATSPYLRTAAAVPGQQTALATFGSLGSWRSSAAVAHYCSTKWAVSGLTEGLAEELAPFGIDVCVVEPGYTRTGFLNRGSDGAGDHRVMTARKLAVYEGTGAAHIRSALQQYDGNQPGDVAKSAKVIVDVLTKEGAAKGRDVPIRLPLGTDTLATIRSKCEATLKLLDEWEAISSSTMREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6X4</accession>
    <name>A0AAE0P6X4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_460870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6X4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="404"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="533" mass="59470" checksum="485AD45AF9843264" modified="2024-05-29" version="1">MDTRPRSVGLSKEHPPKESLLKSIPSRKPKTEEPAIMSTKGEARTVTNDAHPLSESEDSEPPRKRNPNMKRTNFVQKPIKPTNGGRLLALKEAIFADSSSGRSRSPESPKAALRTDFGDKSPRRVPKRARETADEIAGEFEASNGSHLVSKTSIFKDLPIATQKNKKQKLFGGKKGKPTTSPEPDSSLARAHSKLPRKHAELDADSPESKRMLDIPRPITKAEANSPQRKLLKTPGGLGSSVDISPKKKFDLPGPNGKRKTDGTLRSRRVRQLEASPEESQQPIFIIPKVFSSSFDPNEKEDDTAVELHSPGRPVIPDSPYTELDSPEPGDTVCPMCKERVSKDLLDNFKEQYPRMTLQQEQRFCQLHQMESAKELWKDKGYPDIKWPKLKKRIKKQSGFLRDILEGGESHFGDIFSQKVTAGQNKTLLKSEANLTPGYYGIRGLRAMSESIIHEFSSLLRKRAVQDRLVSARGHTAYVQAVLVPELAVRLIMEDMDVDKEEARTIMAESSRLGELMNEEVADVVISEGEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7C7</accession>
    <name>A0AAE0P7C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_51958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7C7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="19806" checksum="EC28B4A569C4CF47" modified="2024-05-29" version="1">MAARGRENSPSSSSLQTTTASQPATTMTITTTGPATSTRSQQVCRSSPAPTDGGCPAINGTIYQPKNAIGQDIILAELGQPQSFKQLCATNHPSGSGSGPNTHLFDIMKPYLPSLEECITARAYYNLQLNVNERILGKTNIGEFGLCRSVSIVKRERDYCYLKNGTGTNDAFGVPLDFASAVLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7P4</accession>
    <name>A0AAE0P7P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor mex67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_555978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="375"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="604"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3394819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71254" checksum="EBCEC66B15A0FFBD" modified="2024-05-29" version="1">MAPPTGPRGGSARTTAPRSSRGGGITKRRAAVKTDRDGDVAMDAPAGGPDNAGGSGRGNHGGRSGGSRGTSRELTRGASRTIQNIKAHLNRTTLKILGLRESKAASNSDGGLRGLVEFLQRKVKGNHPIRISKSTLNGDYAWISVSKEDAAVLLKLDGYTYAGAALKISETSEKWPGTITISPQAALVKENLIKVLANRYNPEQKLLDLSALGGDDILKSMNLFEGQGTAQKAFKALIGTVSMQYDNNAEAKKEAIESVSLARNGLSDVNQVFTLAIELPGLKRLDLSGNSLDTLAKISKWQHRFRDLQELHLTDNPVMTQENILPELLQCFPSMQILNGQQVRTPDQVVEALKALTPTPIPQFTSNVRDGENNVAAIFLTNFFPMFDSDRARLAAEFYDEDSWFSLSVIPNSGRPLPWKSYLKFSRNVNRISSSRDPNLVKRVFTGGSMIAEMWKALPNTQHPAINNPTMWLIDSHTFPDLADPSGLGATAGLLINVNGQFEESDPSANLFGTRTFSRIFILGPSKPSNPPAKNPYRVISDQLTLHDWKPQAVVAEQAPVINPTTAPAANPGMTAVTNPAVVNPVVTYPAVNPITFNVEVPDDMKARLIAELSQRTGMTAEFSELCLSGAANWNFESALKSFEDLKANLPTTAFTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV59</accession>
    <name>A0AAE0TV59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase with different specificitie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_396610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV59"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="33645" checksum="7C68E322749EB4E6" modified="2024-05-29" version="1">MLLFTTKKRGSSVLRPASIINQRSFTASSTNLQTPTDCRFKKPSRDLRGKVAIVTGAGSQGDNHIGNGRATALLLAEDGASVVCVDKQLSLAQRTVSMFSTQSPTGCKEALALDADVTSEQDCRHVIDATLAEFGRVDILVNVVGIMGTRGTAVDVDLTEWAEGLKVNVTSMMLMAKFAIPAMLKNERTDEKPIRGSIVNIGSVAGLLGGTPHLLYPTSKGAVINMTRSMAAHHGADGIRVNCVCPGMLFTPMMYGAGMTPEVRESRRKRSLLGTEGNAWDCASAIRFLAGDEARWITGAVLTVDAGATAAVSVSTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVR1</accession>
    <name>A0AAE0TVR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_475544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVR1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="549" mass="61269" checksum="03736E6C29B91450" modified="2024-05-29" version="1">MSTAGSAKHSRPWMRRFDLASVFLSGGINRYKNPQLVLKKMIDLAPRRSYTGIRTKTAVWRHLLMVHVKDKANELETLDLSAFALSSATESSNLQYTITCAISEFSLVFRYPKGITNNIRTLTINFQSISDFDTVLRELRGLDLNIETPRSQYEIAPAASDAPLGLLVVPDRHASPIFRPISDPGYISHKKSQVAVQSSSQEQYLDGNIPSRHLFTGRSHGTPSIITGRDLRSLASTPGIPSILGEGIYKVSRIGSSSDSRPRRRRSPAIPEFLSKSSYTVSPYFDKCLTKEDIISPLGADSSHEVAESIPEPGNPIDNLARPRTRRYRRTESFSKAAAHDAANILPLPITPDDIGADGAAVEYLDSRSRQPQERVHDLGLGVVYGKSSAANTQQVYARSTPESPPRTRRAFSNILRDRKDWQVPFSHKNEVPKAGYWDSSFANKTSQTSVKSLQAIPEVKPENKVSDAWIFQVADINHAALCEATNIWDELIDKGLDETNLIEDLEEACKIWIKYADEFTRRLETLEASTLRKMRDAQEAAQEEKTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ40</accession>
    <name>A0AAE0TZ40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_395492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ40"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3384787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="629" mass="69968" checksum="DC572A6FEDA6D25C" modified="2024-05-29" version="1">MVYSGKPSRGCQMCRTRRIKCDETKPTCQQCAKSRRQCPGYKEEFDLVFRNETGATERRASKAGASAGKSSSRKKTNTAVSTASKNKNSNSSSPFEGTIIPALQVPTERQATCHFVSNFVLVPRQGSTRGYMDFLIPLLKTETPASNETSSHLQHAFNACALASLANKVGVNSGGGGKELKLPEKAYAEYTRALRATNAALRDPEASKTDGVLAAVLMLGMFENITAKQIGDLAWNTHIEGAIQIVKARGRKQLRTRVGLQLFIAVRTQVIIHCLSSGKPPPMGVDWWLRDAVSDTHAAECQRLNLQTCELRAEITHLMESATRTPDNLDKMVDLMRRAQGLDHAVTEWMASVPENWHWRTKYFPEPPGDSGSKQRRGVPREDYITTVEVFPGGRVDLYSDLWIASVWNLARTARLVLMSITVRCAAWICSPVDYRTTLEYATASRACVEVISDIIASVPYHLGWQEWEQRMGHDDLSTSEFACGQNDSIKGLAGYFLTWPLACVMAQDYTTDNQRLWVRGRLKRIGDELGIRYAHILLQLQIRLPSMLIRRDGLVAQPYPQADNFAKMLTSARHAPPVAAGYALNPLQQREAMLKEKFEQSRDELLDKAAGGATNESVKSVAKKWLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZZ1</accession>
    <name>A0AAE0TZZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_510563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZZ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042099237" description="DUF8021 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="3">
        <location>
            <begin position="153"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="301" mass="32166" checksum="341D2870D6A285D9" modified="2024-05-29" version="1">MFFYSLVLVCVGLVSRGASAACSREFLQGATSAYLQAQAAGSPPKLAVLASNFSYAENDTPLDITKGVLSQPLIIDFSRSIYDTVQCATFTEITAATSPHPYVIHTRMLFNAGDGQATKIESVVTDAGDWAFNATGHLFYTRQETWDIIPEAKRDTRAVIQAAADAYLDQWGNPDHPVPLGTPCVRLEGGFYSGKNLTANTCRMGAFPQPLNVTNRRYVIDVELGAVDVFNDFPWLDQSKPGGATPSTNFIRVEGGTSSPVFSLLPSPMSLETVRQVQGKAAGDDGKGKAAGDGKEGKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0A4</accession>
    <name>A0AAE0U0A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0A4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="205" mass="22233" checksum="F1E1955659EC9489" modified="2024-05-29" version="1">MGGLNIIQTPPPSSHGSQESVLEPMADSRPVGPQGKSKLAMVPGEGSLLDYFDLPSPPSSVMLHRTHSAFPTPPTSPVQADAMSPYNNRLVVSSPLALNPPGSAMHMLPPHRSHYPTPPQSSPSSSASGSEAGGSPEMGAMQMQPITRTARRTAYYPPNSSRNVDRTRVYMNRGPHYMQNWTPLSSLPRHVQLRIEDQMTRFTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0B9</accession>
    <name>A0AAE0U0B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_560592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0B9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="58084" checksum="D2A36D7C305A67EC" modified="2024-05-29" version="1">MKYPILALPVPENPEFFGREGTFWRMHEHLNNDSEGRCSSYKQWLLIFDNAEKWTDLIPEFWPQDGSVGAVIVTSRDSSIANSPATAREELQAFDADERIAFTQSILRDWDVGAEAVHHALGQLFSQLTLLSDAFPKQHHGDPLCESCPVCVLYILHTQALARTWRSAYFREVGDFEGALGLAETSLQACASSAAPVVAPGEKIRHQLVEAHLFNTLGVVKELKFEYSQARAVLEKCLEAHVEIFGPQSLEVSLVKENMASIMAAQGQYGAALKAYQSCLDLDPYAADIAEKNWFLTCGCHYKLAVIEMQLGNNEDALRHMNDAMALAQQIDKQGAGRSHHNNSFLEVETIESKIQAVRRDLEAQLQQQSSETSPDDTTGSKTLLSDAPDKDVFVYFIPWQARPEQEVERTIRGHLQPRVNNGYIGNMFIRVVANAKVNELEPSVGSMIIMPRKGGTMGLEPFEVQLTLGDAGMKKLRNNKELGLWMMKSNAPVVDSKEKEKKGFCGMGMGTDTDTEEATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0I8</accession>
    <name>A0AAE0U0I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_523443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0I8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21197" checksum="1E7D0BAD753916D6" modified="2024-05-29" version="1">MAPPNPPFGLGLIAAGLDADLGRRQDATVAITSVISATATLFTSVPGVTITSVSPPPPPVTVTNAPPPPVTVTNNPPPPPTATVTFAPPVAFHKNTGLSAGSIAGIVLGSLGGLLLLLTLASWLASRRRRRPRPSYYREETVSSRSRHRHSYPPPHHRHRGRHRRRSVEVRTHEYVQPVQTVPSPTKVYVRKSRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0P8</accession>
    <name>A0AAE0U0P8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_558313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0P8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="15002" checksum="B6A109B7D7870B4F" modified="2024-05-29" version="1">MPLGDKAPSPSSSRCGGLKVSFAPEEIGSRRALPRYSDGNFFKDQPLKDSSLPAQSPGRRVHPHHQESHQAAADDSRILIMEDVLDTPPSTMAAIVDFMMMGLGGKQCTLAMWEKMLATVGPKINSISRKGAMEVAGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1J9</accession>
    <name>A0AAE0U1J9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_558767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1J9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="37809" checksum="9E2A49268634094A" modified="2024-05-29" version="1">MSSTTTGVQWSWPPGMGEASGHYMRGGASSFPSSDAQQQTDTTGTPGAPGESPPTQKPAEPRRRHYKPRTCRICLEEVQPTTDIDDSATAGLFTSRTRVRYASEDPELGRLISPCKCKGSQRYVHEGCLQLWRQAAPMSERNFWRCPTCHFEYRMQRLRWGHWLTSKLTRAVLTLLILLVTVFFLGFVADPIINLWVDPLGSLADSLSEVVADIEAIRPVEEEDQVTWSFHFLKGFLSLGLLGLVKTFLVSSPWHWLNVRVGGRRRGGTGRDRIESVNWALVVIGVITFLGATWKIVSKLSGRALESASNRVVDVQGEDPDEDVEDDPTPDQEPRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3D6</accession>
    <name>A0AAE0U3D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3D6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="92" mass="10544" checksum="BC5202F5B2917550" modified="2024-05-29" version="1">MASQPKPTLANIPTELVIKIATFYSLRDLANLGKTCRHFHIVCKDPLVVERVFLEHLDEPTSTSIPNKEALYKIIRRRLAEDDTPKDMAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3V1</accession>
    <name>A0AAE0U3V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3V1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29803" checksum="500C1D3A5B716C02" modified="2024-05-29" version="1">MSSLSSQDPSSSAAAPKVNKDLINRGVYKTNVAGIATFTVLRALDPLLQYKLLKPSGGWGTSLLTKLGISTASFPSSFLVTLGSLTLPLPQAILLAMAVGSSLKQIFWVTYINNEEFTPAISASVSAYNSVVNSLDSLLLLAAGTSAALLAPTYTNGLTLPIAIGASLYAVGITLETVSEIQRKQFKDDEANKGKICTTGFWGLARHINYGGYTLWRTGMCLAGGGWTAGAGMLAWHLWTFLARSTVLMDEYMTDKYKGQWVKYKTDVPYKLFPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U427</accession>
    <name>A0AAE0U427_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_538294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U427"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="112"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="38539" checksum="2421CF1050ED0F67" modified="2024-05-29" version="1">MTSLPHRLDGLRPKIEELMLIAGVSGVSIGVYVEGKANYYANFGYRDVKEKFPITEQTILPICSLTKFFICIALGTIEDILSDRTGMSRGTRYLGSENNMLIAHKETLKFTRYELAGLIIDKVSRLPWSQVVAGIAIRPWGMQRTYTKHSPTSTPNASKEYNVLNEGTPTEIHPVQAGAGSFGGLSGGMFSCVEDLLKAYSTIMTGVNNRGGKQSAIKQLEELISARTRRLHANCSLPGAFSAVTMLPELRVAVVVMSNAQGLEDYADWIHQLVLEEVLDASPRNDYIAAAKTSASATLQWYPKTLEALEKMKSAGNSRPLAEYVGTYWNRKRYLKIDFSLAREGKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4H9</accession>
    <name>A0AAE0U4H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_466254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="178" mass="19683" checksum="1F7071657323E86B" modified="2024-05-29" version="1">MSPSPLPSSMSSRLLRTALRTRRVPRIPIHSIAPRHFTTSSAKMGVHNIESLTDFKRTIASEDKLIVVDAFATWCGPCKQIAPLVVKWSNSDEFKDKVSFVKFDVDDVPDLAQELGIRAMPTFIFFKNGDKLAEFAGANPGALQGLLRKYTVVEGEETKEAAESSKETSPEADKVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4T1</accession>
    <name>A0AAE0U4T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4T1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="114" mass="12491" checksum="42421F32A67B009A" modified="2024-05-29" version="1">MFAFWLEPRKPPTDHQRITEQHSTAQYSTVQHTNDRGHPDLPHKMFMTRAISITNFLVATSALGFQVYVLITGHSTVPPGPSIKSSLLAAVETPPQHTSELLATTTNIAPTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4W8</accession>
    <name>A0AAE0U4W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_466845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="39787" checksum="AC8C5C0291F72887" modified="2024-05-29" version="1">MDGPISKAPTTGTSLSSWTSKDLYSPSFILGFGVDPPRPPKEGHEWVWFPEGYWAEREYRPINSGNRKSTDNKIWKRRRRSAKSQSGGGGSGHDSEPVTESPKTLAPGNPGTPVLSKKEEEGEWLAPKYRGFFPTQPTMSPPEETKPDVPIKAHYQFPSLSWKGLSTSLQRAREKRKSGGSDHSQHQESALRSVQSFLDQIPADSKINDTSEIKKDARGNAKGRRIRFGKKPIITRRKKSFQSSHSFTASIDETLAGDDNSKPRPKSALPAIILPAPPQIWASQFPGGEATRVHTPPLREDTADGKKRGFFFDVNGPLTDQGERSGSTTSTRGTKHTPASQQQGDGSGGSRGNKSTNPTREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7N4</accession>
    <name>A0AAE0U7N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_18069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7N4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042008348" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3393459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="366" mass="39933" checksum="3EA16856EEC8F180" modified="2024-05-29" version="1">MAAGLSIRALLGFAYLLWACALSSASPTKGGPSRPGHKVPIVRREWRILSKHDKADYIKAVKCLLVKPALTPAFNNTGVKSRYDDLVYTHVQQTNAIHFTGHFMAWHRFFTATYETMLRNECGFTGAQPYWDWTLDSPASNWASSPVFDAVTGFGGNGAFIPGDPTSPWEVPGRSGGGCVTTGPFAGDNTLVHLGPFDSVTYNPQCLKRDLAPYFAARYLAKNQTQLTLAQPDFGWFARTVEGGPSFEASGIHGGGHYGVGGTYGQMGDLFVSPADPLFFLHHANLDRVWWSWQKLNLRTRLTDVSGPIYLMDYANALGGNVTLDFPMTLGVSAADLTVADVMNISGCGKTGAMCYEYDKVYTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U830</accession>
    <name>A0AAE0U830_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_444454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U830"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="529" mass="58281" checksum="B04D8F99BAB8C76A" modified="2024-05-29" version="1">MAPPSGLHQSAIPSDFETSVPQPQPGLVRSSTAPVNGALRSHRSDPYHLAPEDAFVLPYSPRRLGGFESGGNGSGHESRPRRMGRKDDTSRSRSRRQKRFQKLLWVKQSYPDNYTDQATFLENLQRNPRVQPYDFWPLVADSTVIVQHVCSVIIFVVCFVGIFQERVSPVSIVGWGSFATFLGWLLWDWWVTQEEDQGDAADGIARKGSMRAFREFGPPRRQSSGLGHPTLGTSNVSISSMSNFPSAASSSSNLVQDQHLQRPVIFGHYNGVSSTSLLNPDHAFSRSASSLHSATSQASAAAPARSSAGEEIPGTSRYRTTSPTRGGRVRLSTIKSAILIYSTLLGLSPILKSLTRSTSSDSIWAMSFWLLAINIFFFDYSGSWVGVHKIPVASLSTNAALMASTVLASRLPSTGQVFSLTLFSIEVFGLFPVFRRYARHRSWRYHVALTVLLVLGAGGGVGMIMGDERSWPWKNGLLGMLVGCLISALAMGGCSWWLIGLQKYKNEIYGPWDPARPIIISRRHWDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U937</accession>
    <name>A0AAE0U937_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_533541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U937"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041995851" description="tyrosinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3395049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="459" mass="50764" checksum="BFAE80253D1F64E4" modified="2024-05-29" version="1">MRFSSAALLGLAPWQVVQSHAETLASQYTGESAAAYQAAAQTLRWPYWDWAVSVESAALPPATTAPTFEINTPTGPVTMRNPLYSYKFQNYPFQDPDFTSSILSNFNETKRSVDFSEDSDAPNDFAAANQALQSNQPQLKDQVYSVFTQSPLFESMSSTASRGPSFESPHNSVHTDIGGFNFSRVAHMQYVPWSSFDPLFWLHHTNVDRHFAMWQAIYYNNTMFNSTQNGRALFGTASGPIDASSPLKPFTKADGTFYSSRDVTSTRTFGYTYPGVNDWALSPEDLSKQVIAQVNTLYGRQLKTTVAAAAKKRSIVRNRLRDFLKVPELKEYSAAVSVDRANLHLPCTIEFYIADQKAGEFALLAMPTTGVGYSSVPLRRTLEELNFTPLDDPVTVVNMLKKTLRVVVKEADGSETPAASIPSLVVEIEDRSYTPPAAQDQFPKYGSITAHPVNVGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K060</accession>
    <name>A0AAE0K060_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_565496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K060"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3367534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="29710" checksum="A7B97DD632664D9F" modified="2024-05-29" version="1">MAQKVVIVTGAASGIGRALATKLVASGWLVGLVDINPDAGEKLATSLGPSTIFAQADVTSYDSQANAFSTVFSHFGGRLDAVVANAGITDQSSVYILPPTGSVSIIPPAPNLAATDVDFKGVIYSTQLAIHFMRHNAIPGGKILAASSIAGVFPHPTLPEYSGAKGAVVNFVRAAGPILQIKENISITAVCPGLIRTPIFRDDVWAALDPRVLTPIDTAVRGYEELLNEEGLEKAGQGILCVGDAIVPVPFPSMPGANVDDDAGAKMMEAAMEPLFKALHGVGLMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0W3</accession>
    <name>A0AAE0K0W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall glycosyl hydrolase YteR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_455697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0W3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF11">
        <property type="entry name" value="WALL GLYCOSYL HYDROLASE YTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042280999" evidence="2">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="394" mass="43958" checksum="1F42D9E7629BB78E" modified="2024-05-29" version="1">MMWLTTAAWLPMLLGSANAAQPYSSWMTDSMIAHGVSATRWYTEATFYRGVEAAHNISGLRTYQAFLASQIDSILAPNGSFRSWDFQDHQLDNIRIGSAILYLYTLDPQPKYRAAADFLYDQLVHHQKRTPSGGFWHKDPKYPNQMWLDGLFMAGPFSAAYVALFFPPDNATAAWDDIVLQFDLTEKHCRDSKTGMLRHGYDESLKAVWADKATGASPHVWIRAQGWYLMALADVLDWFPREYAAARGKLLGYFLDLARAVMAAQDAKTGGWWLVMDAPYPGQKGNYIESSGTAMYTYSLLKAVRMGYYADAAERDVFATAAQRAYGLMVDRFVATNGTKGTLNWEGTVRVGSLDAAGDFKYYTGIPVVENSLIGVGPFILASAEMEAYKARNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0X4</accession>
    <name>A0AAE0K0X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_497983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0X4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="344" mass="38509" checksum="582E58FB9F45B2C8" modified="2024-05-29" version="1">MWLINVDTLELEFHYQEGIKYAILSHVWGAEEVSFQEWKALCCNDIDVSAVLQKSGYHKILECCDQAKRDRFQFAWVDTCCIDKSSSAELSEAINSMFRWYGDSKACYVYLADVPPGTAISDPAFRASRWFTRGWTLQELLAPNNLGFFDADWNYLSDKSGNLHLLANITSIPPNCLNGNAGHTSVADRLSWASSRETTRPEDMAYCLLGILDVNMPLLYGEGGTKAFFRLQEEIIKTTDDETILSWGYKSAVGYAMSQVLASSPKAFARTEGTSIDIIRFAASAPFQMTNQGLQITLDVFEISSNVVTSTDATEGQQCGLSGWRPIFTDSGRQPGRIWQLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K149</accession>
    <name>A0AAE0K149_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_68947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K149"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="28145" checksum="312E7153AD4D3BCB" modified="2024-05-29" version="1">MTPGFGSVGDNQLVFCFIASSNSRVQDSPRETGRQQMPYNSARMERHHRLEDQTGQAEAAAAAKAQSTQDQRGGAHVAAARAQPTPLLQALRVGRGDLSDVLREKRQRGERGGEKGGGRYRPHSGDRRAVSCQWKSKQAPQTGWNMGSHLEEVLQHRAGGCGVLADEMPRLPVRPPKIPAPTQGGHRHGAARRHCCQPCIIIIIILIEPPPADHAAHQHWSQLVPICPRLHRIHRQYCCCCLPYYLRQQLVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1W1</accession>
    <name>A0AAE0K1W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bud neck involved protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_67027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="90542" checksum="ED603C9A851D4BEE" modified="2024-05-29" version="1">MAALVQGYPQQSGTVTMLQTRPTSASGMLQPAQVQSGSHYGHAGSQQRNSIHGFPSGAVSSGSYRGSSGPIQPYAFTNTPSLTPAAQWQQFRTYRTSSTPAVPTMQTFEYNQAAAGRPRYSASVSMTNLPSTGALGVQGGASARDDSILPVPGSNRRAATAPRQQPPQMNGASSSQPSLAPVAPVRVSPERYRRTAMRSVDSGSQSLGQLAHGAVSAAPSGSGVAAVGQSYGSRNVPDQKARSQQASQLNRPNSIALVPGSAADDMQVPASSQSQDDIKKFRRRSMPALDSAGFSQPPTPPEVKQPEESTRLEHSACPNSADRDQKAAAGVVISNNNNSLAVDRSSANPAHVRAGSSDSRSSGRSSGASSNNSSAYRNTNGTSPAVNPARQSSLPDQTGNSQDYPRLVNIPPRSSSSSDAANTKRLNNPSPLSQPVAMDTKETGNSQLAHAAGTTPVSPVKPAEPRVESPAVRQLSAINEKGKARNKTSRLRRAFSFGSAAEFRKAATENDAMENSASSTAGHAKLHKERDPEEVYNAEQARIAQQQEEAGIGSNIYSGGKIFSGSTDNISISSTASSASIMIRKMGRGMKKGTRSLVGLFRPKSIIGAPAADAKLPEASEATVSMVTVEAERELVNVSIDLHSQHGGGTGFPHLEKNSIDAANPPVEDSERLDTSGTDTDASFARKSIIGGEKERAEILAAVRKGILKNTIGPSTPSPRPSDARAPALDLSIAPAMTESPNSSAPSTPNDDSQGHRRTGPISIGSEDYFVSALRLRQDTRSAPGTPHGTMRRNATFSPRIAFYETWPSQEYDRRGEIATCNRLTPMLAQQIKEELNTFKMEMEVHENSKIYTHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1Y7</accession>
    <name>A0AAE0K1Y7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_87605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1Y7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="213" mass="23454" checksum="9081437EE97699E2" modified="2024-05-29" version="1">MGKFPLQSSLTPSAGKARDPNFSSQTSSFGKHLIYNIPRRSTASGQAAMANGIQTVRIEHDVPERIATWLFQTLAFAAAIIFGTWTILGWQEARVANQQSSQANLQSSQANLLALAAFCSQQSSDDASVAKSPGASLRKQQLASLNLVHCGLAPGKCQSHADSDFDDSRHWLTDADTNWRNPATERSSGPRRNRCRSKCRSHRGHRYRCDHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K3C4</accession>
    <name>A0AAE0K3C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_455414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K3C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="620"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126575" checksum="DCD7CAA3BC6EC4D1" modified="2024-05-29" version="1">MADPISALSLAAAVVQFVDFSRQIVCKSKTLYRSTTGVLRENLETETVTMRLREITDHLRATTTTATSTTAATYAASLRVEQLRTECFEVSDKLMQKLHQLRVPTLQRPQVTTLFQKAPPPPSEHRAWKSFRQALKSVWSKAEIDGMASRLAAIRAQLDTEVLVSSNQILISLAESQSSKFQKFEDQTQAILRGLAECRTQQTDLVERFDKLGSNEKTAFTEVVLDSIQHSADYAGLDYTTKDIIRALVEQASFEVGGGDSEGLRWRRRRAAQDLIQKDTEKRAFRARRVAVSILESLRFPEMNHRQESISQAEHQTFNWVFEGDDPVSLNKGDDPASQTEEPKKKKPWDSFSNWLSTGSGIYWIQGKPASGKSTLMRFICEHSETSDLLRTWAFGRELLSEQRSHSGLLRTLLYSILYKKQDIMFQVFPEEWERNQDILNAEMPLVSEKWSLGRLKQAFRTVINLASADLKMCCFIDGLDEYDGDAGDIADYIYEISTISPNVKFCISGRPLSELQATFWDCPGLRLQDLTEGDIQKYVHQKLGSDRQMQRLSRYDKAGAEEMFDLITKRASGVFLWVVLVVRSLVSGLRHGDNIPQLRARLNSLPVDLERLFEVILGKIEAEFKVESSKVFQIFRACGNDLDALELYRILLYEDYESLIRTDLEPDDDPDGSGRGKNTLKVEQLVEMVEEQMALKLSSRCRGLLEIRVINTPKTYYLSPGLGPGLTGPYETRRHLKIEYLHRTARDFVERREYWSQVIKPTEETGFDPHAARLLGYVAGAKLTRFDSAPKEGCGLLRDIAKIPLSASLETVALLDELDRILSFRWKEQKEFDALLHWSCAHDPGFAEFLLSPRHMWPIWGGDMVSAAVRFRLLWYAEAKLGGPPANAANSGPIIINDKNNNHNNKNNNSRLPFLAYAVSFHLWAESTHLPLPNLELLEDLLALGYDPNEKYYEFSIWAYTVHRVHTLAYMGFVAAGHLQAWLEVFMQMLSAGADPHVFCVFNPVLYALAIGYSSDPDNVSSGVLRHFGEVVWSPDDITESVDSDAHDYFAEHHRIDKVISEVFDGRGVDTTQLKITLATARDRWKGVTQSHVDINLLTPPEVSTSAKPWNVRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5U0</accession>
    <name>A0AAE0K5U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_564223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5U0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3369961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31370" checksum="1AEEF3689A8CAE89" modified="2024-05-29" version="1">MAMEPMRKYSHVQPLDDHVDDRSSTEVDESLMGDEKGQRDWHHQPLRKSKRSRVASAFQSYRWIIDTSLLLVILGLLVRDQWRRPDSSLSGGHPWDFGGDLTGVGPKFSQQITTFKMDQTYAPMNTSEFFTDEVLDKWNKLMPVGMGFVWVNDTEKYHDLPTPVDWPDKTVFTTSMTHQLHCLFAIVQTYSGLKANHPIPDDHHWHMIHCFDYMRQAIMCSADIALEGHETTFPDHNGGSDGWDSKHVCKDYSQVVNYLESVRAYDDQQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X6</accession>
    <name>A0AAE0K5X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_485761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3369920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51054" checksum="EDC1FEAEA8552D89" modified="2024-05-29" version="1">MRPPISTILCVPDELLAQILELALAYPIRSWWAPDFDRFFGTSVSVMLVCHRFRRLATPYLYRHIEVAAGSVGPNFPAASPRATGHLHRTFSQDPSLRRYCRILHVHFAASDSEAPWRMVDDLATWLVGTQHLRIDGAFDPADWDWDDRPFSIRRTVRSGHNFKRTWDFIHTAFRNMASLEEVSIRTGNGLLSLWTVIHNLRHAVHLRVVSLTGVSYTGSTLPNNAFQIRSASITSLRLSNFQDSPENLRRLLLFPAKLEEFSFTSFRLDRTWPWDLSVVASALSPHKSTLRSLLVGSLGEKSGSLTGVDLSEFTRLEELSLSYWATGSEAGTEAQLLAPSLQAFSWSFHVEDQQSESYFDFQEPQEKFLRTLVHTAVEERVPLRKLQITFVPSDYGKPGEARPKEWPWDCMDRVVGKEMRDLGVTLSYGEPTISRKDFLERGVEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K618</accession>
    <name>A0AAE0K618_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_497340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K618"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="218" mass="24240" checksum="BA066C7F53491A40" modified="2024-05-29" version="1">MSHLAAGKTAGAKEAAGLRYPSNGKTIYHRPLNRTKTAELSQSSFAYLFSEMVTYAQRRVTGIQELEKRLNLQGHPIGLKLLDLLLIREPARSQTRPLNIISLLHFIKINIWQHLFGRQADRLEKSSNPDTPDEYMIVDNEPLVNAYVSVPREMSQLNCAAFVAGIIEGVCDGAAFPARVTAHSVGGKEEGEMWPGKTVFLVKFQPEVLEREALIGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K632</accession>
    <name>A0AAE0K632_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_486863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142463" checksum="53A92426F496A452" modified="2024-05-29" version="1">MSDTVEIDEEIRAARAALEEMPLDHHDRATYLDILAVALGERYSTEGGVADLEEALRLSREAVDITPADSPDMCGFLSNYGIRLAEMYSLREEIADLEDAIHIMRQVLDTTPSDDPDSAMYLNNLGTALGDRYIRTNRVADLDESIQITQQAIDAAVDGYSDLPMYLNSLSLRLGSRYEREGDVADLEAALRVIRNAISLTPEDSPDRATYLHSLSIQLGREYSRAAAMPVLEESIQVAQKAVDSSAQHHPDRPMYLNTLGLALGDRCAATNADFDVENAMLALREALDLTPEDSPWRATYLSNLGTQFERRYSKTGLAADLNEAVRLMQDAVRRTPKDHPDLAKSLNSLGICLSRSYLRTLNAADLEEAIRVSQEAVNITTQTTEKIAYLCSLGNRLGERYMRTGATADINSAIETMRQAISMAPATDVTQRAMCLNNLGNRLGDRYDAEGIAAYLDESIDTLQQAVDITPENHPDKASYLNGLGARLATRHASYIAMTDLESAIDVMRRAAEITPRTNLSRALILHNLGAALGDRYFRMKKAADLDEAIRVTREAVDIIPAYHPVRAMCLNGLTIWLGKRSGSKGTVISDLEDSVKAAREAVRIIPNKHASRPTYLNALGFRLLERYKYREAQGTADLDEAIRVLQEAVDATPDSNPIKARFQYNLGTGFDYRNEATGVVADHEAALSNFQSALREPNSHIVDRIMAGIAVLQICATTSDWEQAFEASKIAVPLVPKLTPRSLQNVDKQHLLGQIGRMAPNAAAAALQAGRGPTTALQLLEQGRAVLATSLEEMRTDVSELEARNPELAKQFVRLRDELDQPIMRNTFLQDEHGESCQQFRASQRREMGDKFDQLIGEIRRQPGLEDFLAAPSEADMRAAARCGPIIVINTSEYYRCDAILVEHHQIRSVALPGFKSKDIRERTRNSNLGSAETLEWLWDTVAGPVLDALGLTQQPSTEDWPRIWWVATGTASKLPLHAAGRYYANGSGGTDNVLDRAMSSYSSSVRAIIQGRRRRRHDDRDAAISAPARVLLVAIEHTPGQSRLPFAVREIQVIRSLARSLHLKPIEPGRHKQDIMAHLPQSKVFHFAGHGHTDEDDPSRSHLLLGGGKKDALTVANLLETNLREHSPFLAYLSACGTGRTKNEKFVDESIHLISACQLAGFRHVIGTLWEVNDQLCVDMARITYEGMRDGGMTDESVCRGLHNATRQLRRRWLDTTTMPIRAAGRGNNSSATRNMAEEETHGTSGSDEGDRKRRRLLRDVFACDDDEKSGPLLWVPYVHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9J4</accession>
    <name>A0AAE0K9J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_439937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="8"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="967"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2415"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="967"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2530"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2547"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2556" mass="280398" checksum="CC4E9B0BC2CCDD8C" modified="2024-05-29" version="1">MAYKNPISEPIAIIGSSCRFTGGATSPSKLWDLLSYPTDLSVPIPPERFNIKAFYHPDGEYHGTTNSPKAYFLDEDHRVFDASFFNITPKEAEAIDPQQRVLLEVVYEALERAGYTLQQYAGANVAVFTGLMTADYDTLSQRDDLTASQYYATGNARSIVSNRISYFFNFNGPSMTIDTACSSSLVALHQAVLSLRSGESEMACVTGANLIITPEQFIVESNLHMLSPSGHCRMWDAGADGYARGEGVAAMFIKPLSKALIDGDRIEAIIRETGVNSDGRSKGITMPNWEAQARLIKNTYRRAGLNAGAPEDRCQFFEAHGTGTLAGDPNEARAIEDAFFGRAIAAPAKAAAATPKLLVGSVKTVIGHTEGAAGLAGLMKVVEAMHHGSVPPNLHLDTLNPEVKKYYANMLIPTDLVPWPVVPAGQPKRASVNSFGFGGTNSHAIVEQYVPELHDEVAKLFYHDMAVVPKKVASGCCAQHGQVSLPLVLSANSQKSLVVVAQLYRDYLLRNNNLFHCEEVAWHTYAHRTAFPYRLAVSGSSAPEMAGKLDTLIEKTHKSSTATIGIRARPESDEAKILGIFTGQGAQWATMSSGLLRTSEVYAKTIRGLDKVLQACPHPPTWTLEQEILAEEELSRVSKAAISQPLCTALQIAFVDLLNSLGITFHTVVGHSSGEIAAAYAAGRLCSRDAILISYYRGLYAHLACGASGAKGGMLAAGLSKEEAAELCAKKQYCHGICIAASNAPFSVTLSGDLDIVHQVCTELGEQNKFVRTLQIDTAYHSPHMEIPAVKYLEALNHCGICPLPIGNGTTWISSVYGSGESDLVELRASYWKDNMVKPVLFYEAVGTALEQQGAFDCAIEVGPHPALKGPATQTMKEKLDDAIPYSGVLSRKLDDRVAFAEFLGWMWTQFGSASPQIRLFVLGSAQPDLVHTRLEGLPVYPWDHSQIHYRESRLSRQYHFKTHAPHELLGSRTRDDNEFELRWRNIMKLDKLPWVKHHSFQGQALLPASAYLVMAVDAAKMALAGRPASVVELLDLKFPAGITLEPDSVGLETLFSLTIDPRNFTSSIMEASFTLTSATADGSIAMKKNFSGKLRVILGAPDAHALPMRPQDRAETLHTIPEAFYDMMVGTGLVYTGPFRGLATLERRYNFASGTAKKLHPEDTTRLSISPAALDSCLQTAFVTISSPGDKAIWTSFLPEKMERVRFNLALCDIRGEDEMIAIDANLTEARPITQTASASFTADLDIFDASGHMEIQVEGLTVGSFTSTKPEDDYELYLTTVMDVDPEDKIISTSLSSIHSSSPMLVESCERVASFYFDLAAIRRICDSSQRIFTPVSSYKDLQVAQKVWPKETNKTLDHFIRTSPYFTTLNFIRSLGENLPDVLLGMLPTAVEEAHQLLGFQKHVSRVVSQISHKYPRMNVLTFTDPELGLTEHVLSGLKDTFLSFRIGATRETNLDDRALLTEPARKKVSVDMIDLDANEIVNVSGVHYDLVVLTTSLLPPAHSQAVLRKIRQVMRPGAFLLLVDVSRSPLKDRIRRCASLQLTGSVHDHADGLATPPDWPDVLDVCGFRHSIKNSQQYYPPGFSLTIRQTDSHAKHALLNPFAHLGTSHHGPHVHIAERLLVVGGKQLWTSLIAAGVVQALSPRCGQITTAETLDHVARASIESYSAVILLNDIDEPILAGITATTLEVMKGLLRPQMVMLWVTHNARNYSPDHAASFGFVRTLIAETPGLVLQMLDLDTIDTCPAVDAVVETFARLSMHVLAHTLDDGKPAPLLMYEPEIHIEDGHRLIPRVLPFQEANDRVNAPRRVVSKAVNTLETRVEITPTQFKYASSKYETKIETIEDFQSSTFPHESTLQVDYSTADLLNVGLAHSANVCIGRDIKTGKTQVLLSKSNASYIKTGGYCVVNILPGSVNQPVFLALLVRYLTALTMANVVEDEFQDNKSILLVEPDVMFQECAKDILVKRGIWFQVCATDANRCRITPGMTFIHPRSSTREIMALFPPNGTWVFDLLPESSEVSYILIKSLPKNCEYNSRATLFASHHCHLPEDPSMVGKIWAEAVGLALAKAENWSQMQEPEPALMSIPELLEPGCSTAPFQLLDWRAERSISHIIKPFVGYGLLSPNKTYVLVGLTRDFGQSLCTLFIEHGARNLVLASRNPPKQHPKWQVELLSRGINVQFEALDVTNPEAVVAFKNKISITMPHPVGGIINGAMVLEDKVFSVMSLETLHRVMGPKTIGSKNLDTVFDSPDLDFFIMTSSFAAIGGHPGQSNYAAANMYMNGLAASRRQRGLSASVLNIGVIYGLGFLHREKDELYEGLEREGYPPISERDIHHMFTEAIAAGKPVPSQVVDLTTGLRRYPVTRPTLHWHHDPRFSHFTLPEVDSDDNDLSDGEAKKSLKELLSGAETQSDLVGALLPAFIGRLEGLLHIQEGHITGDNSIVELGVDSLVAVEIRSWFWKNVAQDVAVMKILATPSITKLCVEIADAILHSRMPAMKLGVSMTLDEEVFTPVSTVFDEDLAQKTKASSAASSMPNSRAPSPTPKERFASAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAI8</accession>
    <name>A0AAE0KAI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_497059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAI8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="958" mass="105610" checksum="91F55E78E1AD32C0" modified="2024-05-29" version="1">MDLDIDLDCLAWAAEDFDYAFDEIHSQLGAKDCTSTATGFPLDLLFAEDEGTSCDMFGDASMSDAVGDTQTMSNSHGPQLQSPADYVLPPAVKPVASDYQSLHSDTDAETSASQPLRRQLSLLAKGSCGDVLLFRNCEPSKAVVLHSLAMEFGLGYAHDVWNQGVSISRITTESGSSFIEAAHTQAVSHSFTNHGAAPPSPSVAIHGFGIMTQYSRQTFDDDASLLTATPSIGENNQLTRQPSRSRRLGESISKHWNASIAKGGRRGPLSETSRLAMKALEEAGGACWRCKVLRRKCDPGTPCRCCLQSVPIPHLGEDAPLWPLIGCRRGPLRESIPMQVFCPESQGQSRPETSGSDQTLQPRRSLDIAGRCLLSAESQRLADMKASLECASYKLSIDDPALRDSFISFIEAGRYRNQDSLHRAFPHQGTAVTYADLIPTIAWELAENNILLPLLEIRSWDAFMEMLETASIYESEIGQTSLVMISLICLRHCFEALRLHSADLLNPRAHVSCRAGQCQVHYIRDLSLSVTAYIDELSSVIFNKDNMRDRRWWLSTFYSLCIQSHVRHAVIAIEKQLCFQSADEDLISTQYLHLAAMLFTAASAKYDPLLGGRHQYTVTENENSVTRETTVPELHHSSARKVCEVDSWPECGIKSSYEFLRRALQIGSLDFASGQMDHPMSDLQSPSETPETSDPSRRHQQRDSIFSITSLTSMAISNPSSVSLTRTLDTDVTSIFDSIYEQPLSPVKASFGDDSASLSTARVHVEGTTANPPPVSQTDKSGQATLVAPNSEASQASVGEAGSFICNCCPRGPRRFATSEELATHEAEKPHPCSQCKKRFKSPTEAERHINAVHLKLDFWSCQALANPLDAFHSETYNGEMYDICGLCGGGFAQGADRDIPELISHLESVHKHGECDRDKKFFRVDNYRSHLRIAHVSKPGKWLKVLEKTCRMTRAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAR6</accession>
    <name>A0AAE0KAR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_551550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAR6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3372682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="37035" checksum="2C9452D678079768" modified="2024-05-29" version="1" fragment="single">QKWFEVYSSLASSGVNVVGGRVAGPAVGGLTLGGGYSWYTVKQFNVVLPDGTITKATPTFNQDLFWALKGGMNRFGIVTSVVLATHPQTPLAWSGFRYYTGEALPALVDAIDKFYATSQDPKTELLPTFYAGIEGGLTPVFFFHDGPNKPPAFDLFDNITSLVDTTHPQSFSDFAASIPVTTDGVRTRGAFHIFSTTALTRKFLEAIRNETVAFYSIAAQHPGTTASFDVGPFTKFGQFATDSAFPHANSPLPLNIYFTWLLPSEDQFWYGQIRDLVARLKAVATAEGIFEKGVASYPNYALANTTAEELYGSVNAAKLRLVRLRIDPFRIMDLAGGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE71</accession>
    <name>A0AAE0KE71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S8 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_548760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE71"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF5">
        <property type="entry name" value="PEPTIDASE S8 FAMILY WITH PROTEASE-ASSOCIATED DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="2">
        <location>
            <begin position="216"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="509" mass="55006" checksum="6922CB876E6A07C4" modified="2024-05-29" version="1">MAIITINGNSIDTEPPTLQGFGLVQETAEDSDYILIQTNSPLTKDIKQQLVEKEVVVQEKVSDDTYLCKYTPSDLSAVRELPFVTYANIYQQHFVIDARLKHTPASSSHAHPLLAAPAPTERLVTVDVEFHPDVTVSPEFISSLATAARVDEVFLTVENHKTRLTAQQRYLGDLAALDAVKSIRQVHPVKLHNNVARTILRANKAVHPVNGTQYAGEGQIVCVSDTGFDKGSMEPPNVPEAFKGRVKALYPLGRKPTKKANGTVVAGKASDPDGHGTHVCGLVLGDGASASMGGRIQGTAPKATLVMQSLLDSRGGLGDIPTDLTSLFQQPYTDHAARIHTNSWGSAPDSFEQLAYDENAREIDNFVATRRDMVILFAAGNDGMDMKPSDGKVDFSQVGSQAAAKNCILKPLGTDNRGPTMEGRIKPDIVAPGTCILSTRSSAPDARQKRHLNLIVISPDAKKKDTPTTGNEPYDRLNNVEQITVLVRAHNVSSLEGGQTFALAWKVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEG3</accession>
    <name>A0AAE0KEG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_263611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEG3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3375004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="94120" checksum="5699EB1BA5EC5397" modified="2024-05-29" version="1">MDSEDGEYFVKQLAGFVRTHEKALANALQFKRQNAPRHGASQSVSSVSPIAVPTSPSVPERPSTSASTSSTLAAALSLGNLSFTSHTVKSAKLALTPHHLFYLLSRFEELGIHVGPMKVRLENLHDSTTSANYVSFLGQSQRSKTHGSEVGSIRSVSSIRSVMSGMSALWASFGIGSSISAARTERQKAAIQADLKYLYSAFTKIPCLRLAPDWRARLIKGYEEFPFDSAVPLYVFKNVQALEVSDIDFRQFFGWDRLADQLRSLTVKRASLDDPADILIDIVLDDMDKRRRRSSKAQTSPTTAWTQSASPRRSPTVSHAELHKSTSAPGSPEARRSTTDLPVGSLSSELGTDQDGSNDPDSRRPSIVRADSDEPRSPTKESRPRSHSPRRPSSSRNGSANPRGSYKIRRSGSGSSHSSLSDSWHNSRGSSSNLLAMGILPASKWRFLKHLSLADNSLTSIPSSSLSPLSNTLHSLDLSSNLFTQIPDSLANLTALRALNLAQCMIDSLHSLTRNPLPAITALNLRANRLQSIAGIERLYPLERLDLRDNRLTDPLELARLTGIPEIREIYVEGNPFTRTHRDYRITIFNLFRKTPGYTEDITIDATGPTYAEKRYLVERADEPPAVPVIKPAPPDIPAVDVSKPAIIYDAPLKEPAVLRKERPIPKSVSSEVNTSSTRRRRAPKRRIVDLATNETPIPHAQPVDRHGANDAAVAIGSDGNYLISQPPPTSKIFQKALAESPHPNTQGPPDVPRIDTNVIPQLPPIYTSHESPPTNHVWNESPNWDGGELYRRKIEALRDKVGTGYLSVLSEEGWDPAFRPPDYHESDFGPTSPIHTNPTTPRATSIHAIHSGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEJ0</accession>
    <name>A0AAE0KEJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_563193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3375258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="436" mass="49064" checksum="07B73084997200CB" modified="2024-05-29" version="1">MAKDSTLEKRKRPEDGSSKEKKNKSAERNQQPTLAVTAHITKIMKPKISPPVVAVTPGIVLSDTKEFYAYNEENPAKRRKNGAATELLLHSFNQNMDYTARNERPRGAEPLLNSYLAIYDPISGDMQLIEAQKMVVRGTVRKQKASDEAMADRTQKQSMYDMRTELGEAFGTKKSKKAIRAVVENAITAPAGDKLANGDLAMVNSIRNSSKAMATREELQAVVDQARPVPRGNLDAEDIQDVYVASEIIGAELLNSIPVMDWQEKTKALQPIEVPSRFVANRIARVASNENAVERLKVMRYLLWLLILWGSVEKGRDRGTKTLANRGQLRYLLAPASDLVIESLRRKFTDNGVMRKTHIDLLMTHCCTFASIIDNFEVDTFDLREDLKLEQKQVNQYFQEIGAQIKVSKAGNKTRVIAKLALPLQFPQIRQGRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFI2</accession>
    <name>A0AAE0KFI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_261919</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="508"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3374960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="946" mass="104387" checksum="0DC9616881B44888" modified="2024-05-29" version="1">MADRPSSGSSSRRAAKMSDDAVGQFVIDQEIGKGSFAQVYSGRHKVTGALVAIKSVELGRLNKKLKENLYSEIKILKTLRHPHIVALHDCVESGTHINLIMEYCELGDLSLFIKKRDKLITNAATHDLARKYPIVPNSGLNEVVTRHFLKQLASALKFLREGNFVHRDVKPQNLLLLPSPQWREINKTTKQILSASHDSLTPAVGLPSLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDAKADLWSVGTVLYEMVTGKPPFRAANHVELLRKIEAADDVIRFPRDSVVSTDMKGLIRALLKRAPVERMTFEAFFQHPVITGPIPGLVEDDIPRTERHSTAKPNLIPRRNSFQRYPTERESISRSPKSTRGPSPLSTPVEPKPNPLEQAPNYTSSSPRQGAGEGLGIRRPQPNSLPNRPPSYHERLRRYTNESVRTPIRETSSPALSLLDETARNRPKPRVPTEEERAAQEVAFERDYVVVDKKHLEVNALADQISLTQPASPKSGPMVRRVTQQGNPTGVSSPASRNYQMGGRNDHHRQGAHGEKALSSSPGGATSVISKAIQDASLRLFGFKYSPIILGKGQSPPQIYSPFPAYPTPSAPAGLIADGKQSMPVDEDSRVAQCIEDYATRSDVVFGFAEVKYKQLIPLAPSMEVGLGGVPAQQMASDEEEGLTVEAVVSLSEEALVLYVKALSLLAKSMDIASLWWTRKNRTESSGSVHSAARDSTNGQALTLRINAAVQWIRTRFNEVLEKAEIVRLKLIEAQKQLPKEHPSHPDNHTTEITSTSSSSAEGVFVTAGISAEKLMYDRALEMSRAAAINEIANEDLPGCEISYVTAIRMLEAVLDHDDDHLPKRRVSHSSRDEKAAAVQDEESNEMSSNDQVAVQKVIQMVTGRLGTVRKKLHMIATASRAQQQQQHNMVRRRSGDITPRSVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFM5</accession>
    <name>A0AAE0KFM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_266877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFM5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3375091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="504" mass="55728" checksum="9D3ADAA0C7D6B0A0" modified="2024-05-29" version="1">MAARVALRGSAILRTIRPAACSLPRESRRQFSFSAANMSSFYSWEPEGPTIKTQIPGPKAKAQIAELDEVFDTRSLNMLTDYEKSSGNYIADPDGNVLLDVYAQIASIPIGYNNPVLRKAAQGDEMINGLINRPALGNFPPNDWANVLKTGILKVAPKGLNQVFTAMAGSDANETAYKAAFMWRRQHERGGHHVEFTEAEMASAMRNELPAGSSELSIMSFKTAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQATFPLLKYPLDQHAEENAAAEAASLKEVEDIILNYRVPPCAVVVEPIQSEGGDNHASPAFFQGLRALTRKHNVLLIVDEVQTGVGATGKFWAHEHWNLQDPPDMVTFSKKAQTAGYYFGSPELRPNKPYRQFNTWMGDPARALLFRAIVGEIERLDLVNNTARVGDYLYGKLEALAQKYPGQFENLRGKGMGTFIAFDSPRRDEFLARAKGFGVNIGGSGQSAVRLRPMLIFEEKHADILLAALEKIVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFN3</accession>
    <name>A0AAE0KFN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_275997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFN3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3375322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="19954" checksum="031A1448D3E0A3D2" modified="2024-05-29" version="1">MAASGLLSPGPYHILSYGTLLGTTFFHTFVGGIFSFQVLARPQFSILMAKIFPVYFSLQTALPVVLALTYPAASAGAALLGGNGTSSLSGVSGVLDPANRWSVLVPIGTAFVTALANLAVIGPATTKCMDQRKLQEKKDGKRSYDAPPHSQEMAELNKKFSLLHGVSSVLNLASFLATAAYGFTLSARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KIV1</accession>
    <name>A0AAE0KIV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_218819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KIV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3377436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="565" mass="63969" checksum="DA072147E8EEF6D7" modified="2024-05-29" version="1">MLEQLFLAALPLLFAYLFAKVRYSRFKQYASFPQLKPSLVWGHMKAINDFTVRGKLDRHIDDILGEMSDELGNPPFLMLDVRPAARAMLVITSHDVAEQISKSSKLFPWSVTKSPTFGPLEYIVGSRSILIKEGMEWKNTRKTYNPGFAPQHLMSLLPCILDKAEPFVKNLDHYARSGETFRLDELTIGLTFDIIGAVVMDTDFDAQHLDKSRRGELIQLFNKLTHTYQNFDGQLPWWFYPRREYRRWRLSVQIDRAVKNIIRQKFEEQQQRQQSDSGHKLPSRSVLALSLQGTDKLTEGLLSSISDQVKTFMFAGHDTTAILLGWIFYDLSRTPGALKTVRAELDEIFGPDPDTDSVRSKLLSKDGEDMVRRMSYISAVIKETLRLHPPAASARYSAPGTGFVVRTPQGDDVCLDGIVLYNCHKVIQRDRAVYGETANDFMPERWLGDSDTSMEDKDTHSTGTDHKKIPASAWRPFERGPRNCIGQELANIEARVIIAVVARRYDIVKIGMGEVDLDEKGQPTLNEKGQYKVKSELYSTQNVTAKAVDGNVMKVRLAPKASGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJT6</accession>
    <name>A0AAE0KJT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_236424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJT6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031005">
        <property type="term" value="F:filamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF1">
        <property type="entry name" value="FILAMIN-BINDING LIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="602"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="77659" checksum="95229D97F9207A1E" modified="2024-05-29" version="1">MTGAVRESSFMPTVKCSNCGKQVEISMMGEHDCSGAPTAEPTPPIPAPSLFERFLPFGAASTDKQMRMLPEVDTSAANRVYMGQGQLTPVSLSSGSRSVSPKTPNGRPGSERADEYFSPRIANDSPPPQQSRRPGGYGGFGDGNGYEDPAYPANNAKKQAPSLMDRMNTIAPGPFESGRRPPTTGRTASAGDISNDRPSTSASNMSSSLGSIGNAKVPRAPRKNGYGGFGPPRRAEGDVEPQPLSLPNRSETFPRPSEVLEPPMRTPSAPGPRPDRLRPTSPEDMDPRTIMTSERTRRPSRGPDTSRPPPPRSAGIPELVRPKTPGVPAINLAEEFGIGNPYHASSESSSSTASDFSQSERRPSQASSRTSPPRSLASRSGGRKPSDTSLDNLMTDLQSSIEEQKPKAVVSPLSPSPGDLRGRPSPFASRPPRTGGYDPRIDPAMQNGRARRPMSPLASPALVSPVLDLPDVDRFPTEVVVDRQFDNEPLPVLVSPPSPLVTRSPERIRDPSPPQIKEPVRSRSRSRAREPVVQSSRGDCKDCGEPIFGKSVASADGRLTGRYHKACFVCFTCRQPFSSSTFYVLDDKPYCHKDYHELNNSLCGSCNKGIEGQYLEDETTKKHHVGCFKCGDCGMALKDGYFEVNKNSYCEKDAWRRVQQPWIANGGPPPPRKGPTLGPGPRPMNLGLPGGPRAVGFGARSPLGPRPRMEKRMTRLGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK10</accession>
    <name>A0AAE0KK10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5S rRNA binding ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_451554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK10"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="303" mass="34934" checksum="F413F5A7D97DCA56" modified="2024-05-29" version="1">MVFHKLVKNSAYYSRFQTKYKRRREGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIVMQIVTSEINGDKVFCSAYAHELKAYGIEHGLTNWAAAYATGLLIARRVLKKLGLDEDFAGVEEADGEYTLTEAAETDDGERRPFKAFLDVGLARTSTGARIFGAMKGASDGGILVPHSENRFPGFDMESKELDAETLKKYIFGGHIAEYMETLADDDEERYKSQFSKYTEDDIEADGLEELYAEAHKAIREDPFKKYESDAPKKTKEEWKKESLKYKTVRLTHAERAEKVQERIALYRSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKB6</accession>
    <name>A0AAE0KKB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-threo-3-deoxy-hexylosonate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_479309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42297" checksum="EDE853335FCC2159" modified="2024-05-29" version="1">MDGLLLALRPLYPFISLRRLFILAPPISSTTRCYFTGSNTPTLCATFQPRPQAPGRVLSRLFTSNTIMTVSNGAANGHKTTGRPLPCGIYAPTMTFFDPETEDLDIPTIKRHAERLVRDGLAGLVTMGSNGEAIHCTREEKLAVTQATREALDAAGFADTPIIVGATEGSVRGTVELCQLAQQAGGDYVLLLPPSYFRLLMDEQAVYDYFIAVADASPLPLVLYNYPGAVAGIDMDSDLLIKLAAHPNIVGTKFTCGNTGKLTRVALATDAKTPFSEGSGYMAFGGVCDFTVQTLASCGSGIIAGGANVMPKVCVKVWNLYAEGKRDEAIALQKILSKGDWVLTKAAIAGTKQAIQSYFGYGGYPRRPLKRLEKARVAAIEEGVREVMEIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKF4</accession>
    <name>A0AAE0KKF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_228484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKF4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF17">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="528" mass="58280" checksum="F0219EB37FA39B44" modified="2024-05-29" version="1">MSRQREEYRIPCHDTAFLDPAHPLELSLSCLDYLSPQHTLDVLLFLPIENERHNGSITKLLRTGLRQTLTRFRTLAGAIKTGPDGISTVVIDKSDYISLTVQQLQDDQDVPVYQDLQEADFPQHLISPSKLVPELEQHEKHKQSILAVQLNFFTHGLAIAVAWNRTITDFQAISGFLEDWARTCSWGWCTSLNGENPFSAATSLDTLAREPLRHRTSLPIDSSRSAEVEGALIQKGVILPTVNYPKCAAAAGTTTASSSSLAVRHVVWFFSEQMAEELRQEIGTEVMFGKAPTVEIALAALVAGGPSLTNLSVFAFTRRLANNELFLDDGIARAARLLVETRDLNPLSSSLSDNTTYPLLHDWVSSHADKPTLSVSRSNCCCCTNFGVAITSWDSTCPSSSPNAGFYEEIDFGFSRIDRIRCSRPFPIGRGGGMSGSALFYPRIRYGGARGYEVVTTLQSKHMGELLRDEKMRRWAVPRGTPPEKNPQDPPPSPRPSATSVSPVLLSSCSFCSLPFCFTCPERRGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N163</accession>
    <name>A0AAE0N163_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N163"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="294" mass="31476" checksum="F13A19044A0AACDB" modified="2024-05-29" version="1" fragment="single">QSPLSSAQRWVVRSVSPATVPLLPNRSGPALTSCPFMSTQQNNSLPNCETVAAGSNGPARSSDPLSVATAPAYHDDVWEVPESDYASEQETDTPATSAPGNAAKPHRRGAVPLAASRARRAKKPDQKLLAWLEQKLHLPAEHGLHHQLDLNPPIDQPESLRPQGKASAAAGAQKSLPNPVGRRIFSVGAASTLMHRRPRAAQQRAVQQRAVQHRALRSGQLPAERKDPILDGSQCSIVMTAAVNKLDVGSSVKRHVVPMSSLQGDNLMEKKQILTGGEDLGSNELECKALMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2H2</accession>
    <name>A0AAE0N2H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_488204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="6819" checksum="60810357278E2F63" modified="2024-05-29" version="1">MDVGFGLLPGDGSAVNWAAKRGHLDIVKRLVLAGAKTDIDAKKPAWLGGPGALLSSSQWARTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2W8</accession>
    <name>A0AAE0N2W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_81671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="134"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3367454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="43533" checksum="F1874F5212DCB09F" modified="2024-05-29" version="1">MANKDSLTESKTLSLWGKVSLFGLIPVIIFRWIIGFAFPTNKALHWRQSLALTFQQAQRATLSTDQLRWVTRRTLTGTVVRQYCDRHQIPHDEATIQPSTISVATRGIDKSVSVPSSTLHFVTPASAAAAGPTLLYFHGGGFVNPLRAAAHMPLILSCASACKAKQVAILEYALAPQHQYPTQFVQAVLAFRYLLDNLSLCAEDIILAGDSAGAQLAGAVLAHLADPSPYVSTVSLVGRIRAVLFMSPFTLLQENQESYDFNNGKDYLNRPQVRAFKDDWSPIEDEVWANLCGAEDASEVWGRVFPSLQSKGLVKKAMIVVGSAEVLLDNSREFARDHLRAETVMANRETDWKVLDGKDFVLVECEGESHVQAALDAVVGHDKGAMTLAIKAWLANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N354</accession>
    <name>A0AAE0N354_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_489642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N354"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="226"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="353" mass="37865" checksum="11F19D6418F2C771" modified="2024-05-29" version="1">MPIPRYGVWKGIPNKWEPTSKPGHGHITFSDGASSHLDAAVNIQSQSADSRLVYWFLRDFDKTHPIAQGLQSLNQGFFAQNGPSSLGLDFLRGNFLDVNDGILLSHDAPGESHDILDYLNPILNQAVTKKATIYLFGQKYSGNDGIHDIHMNQGNSGQWKRDNGTYQDGGIVLAFPDGHWEGIFLAFAVQTYQTDSTGQPVGKTFADLLSGKAGPAPGPTPEQPGPEPEPQPPTPAAGISIQAALVNPFGPDQTPTRGEGETVYLLNRATEAVSLEGWSISNGAGQTQALHGIRLGAQSKKAVAVPNAPLSNRGGSIVLKDSSGKVVDKVTYTKEQATIEGTLVYFQQKQLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N368</accession>
    <name>A0AAE0N368_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_565144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N368"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="35443" checksum="D193EE02D05B3DFD" modified="2024-05-29" version="1">MIRTVSTHSCAADALLFLRIRQLDNGSMASSSAQVKPLVNAFSELGTFKALAEYTDKTVSRTKMYDGFVDAVREDSVQEQNLSLLALASIGKSLHQFDDQAEGYGFRKGTDKGRCQDAIQDALTTLLPPMLRLHIGEAIKQYNEFIQQNPSDPLRAKPVPVAPLHPCKEKTNSFKTSLVETSFQKKASSTNSRMNALFVYTYLQHQGQVPDALQQYGRFNGTTFLKADDARNRLPQLPIWLDSNTAAAEGATYSEILRKMAWADKVDQKGPRVGQKGLSELKDNTAFLKSILERAPLTGLYMPPHEYELSTATSKSCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3Z1</accession>
    <name>A0AAE0N3Z1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_304330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3Z1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3369912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="554" mass="59603" checksum="2F9D7A0C8E611758" modified="2024-05-29" version="1">MSSTARGEQSPTPGVSSRRSACDRCRGQKLRCLREGADPDGRCDRCAKADAQCVTSPIYHMRNYSIQQDDAPITASSSHKRRRQDTYRGRDIDQQPQQSQQRQQLPSQAPSTVGPAVSPNTFEWPQSVDPFGRSPNNVEPSSTGFSPPSWSTLVDSMVAQPSASAPPPVAVHSWDAGDLNELEQILAADGAARPFASFDKSNKPTRGDDNSNNTPSSSGPPLQQPTADPQTGGPWMGYRDDVLADSSLGAFSSLGLGMLKDSGPPASSESTRHTEVLSRLNLDLVKQLKRMAKGPPSITMKTIIAADCTSPSDLGEITTPLEDILSSTRQFLDVLGHIAGSPSVPTPAVTNAGSSMPQYQKPTVSSASTSSASQDDSSLSSSSASSPGPSPQPSNSSTASGPKNYPDMSTLLLVLICYVHVLRLHVALFAHIRDYLQILAESENRTLPTLPGGLPGFDNFPVESGNLQATMIIHYVANTLDKIETLLGLPRELRIGTREDSSHGLLRNERFLEVAESVIRKEDVGREVEGKGGIRSLRRNMKKSKRLLRSRINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5N5</accession>
    <name>A0AAE0N5N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_440755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5N5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="352" mass="39716" checksum="8731BBBC22C509F7" modified="2024-05-29" version="1" fragment="single">MLGCPGALDDFIKGNRSDSFLPYTESNLPDVIKGATLRSKFFRLQRVVLCNQKDVSDLEHGGKHLHLSGPGDNYFERINMLGRGKFGVVDRVFSRQTLQQYARKVIHRGASAWLDSRMCRQFESEIQALKKLSHPHIVKLVGSYTDQDHLGLIMTPIAEMDLNEYLRSPSIDPVLRKRCLRAYFGCLATALAYLHQQDVRHNDIKPKNVLVKDSSVYFTDFGTSRSWGAEEGSTTIGEHEGFTQRYCAPETHETKGGRNRSSDMWSLGCVFLEMATVLLDRPLSDLDMFLEQNGTLRADAFWANPEAIGLWIKELRGPRGSSSTCDDSEVLAWTTELLQQSPDDRPTAAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6E5</accession>
    <name>A0AAE0N6E5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isy1-like splicing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_285221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6E5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3371985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="246" mass="28161" checksum="84B9385A7E86E47A" modified="2024-05-29" version="1">MARNSEKAQSMLFRFREAQAADLGIIDAGRTRRPRAITEQDSIPLCEKWRGQVLKEISRKVSRIQEIALSDYQIRDLNDEINKLMREKHMWEVQIRNLGGPNYMRGGAKVYDESGREIPGGGRGYKYFGRAKELPGVKELFEAAAKLKQDDEKPLETRTDLRKQVDAAYYGYAPGGEDDVLLEYEATKERDAFENLAMGGSEEPPLGWEPLPGDIGDGRGWELPAMEEVQQELIERRRKRLLDQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7J0</accession>
    <name>A0AAE0N7J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_484434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7J0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="122" mass="13932" checksum="D3A841BF7D57AA3E" modified="2024-05-29" version="1">MLRRRYGARAMHALQNYGEEEPAYNGNAYTYSSTYHAGMFRLYAHHPTAPTTPGGRPEYHMTQIKGFDMLSDQNAGVDGMKYFRNARDLAQRHRDKFIQEGNARARRPDALLVDEPEAAEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9I0</accession>
    <name>A0AAE0N9I0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_482252</name>
        <name evidence="2" type="ORF">B0H63DRAFT_490680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000015">
        <property type="protein sequence ID" value="KAK3366337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9I0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13471" checksum="52E61DAAF615BA5A" modified="2024-05-29" version="1">MKLDTHYHPSSYNKVPTASMLPGLELRGLILLGTLDVRRRRPKLMVKELKISWCWRFVWVKGRSLGCRTFGGRDFGFLSPLLAGDSTLLSVLLLLLLLVFLRLSLFCFESLPLGLLSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9W8</accession>
    <name>A0AAE0N9W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_452665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="10"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1040"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3374834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2682" mass="290853" checksum="2B50B0AA44092C15" modified="2024-05-29" version="1">MVSRPEMFASKPIAIVGSSCRLPGGATSPSRLWELLETPRDVVQQIPASRFSTEAFYHADSQHHGSTNIKHAYLLDEDPRGFDRDFFSINPKEAEAMDPQQRLLLETVYEGMESAGYSMQQLRGSSTAVFVGCMFYDYQYTAVRGIDSLPQYHATGTGSSILSNRVSYVYDWRGPSVTLDTACSSSLVALHQAVCALRNGEASMAVAAGSNLILGPEPFISESKLNMLSPNGRSFMWDSQADGYTRGEGFGVVFLKTLSQAIADGDHIECVIRETGVNSDGKTPGITMPSYESQARLIRDTYARCGLDPSRESDRPQYFEAHGTGTPAGDPIEARAIQSVFFPNDGETDVDKREHRELMVGSIKTIIGHTEGTAGVAGVLKASLALQHGRIPANLHFQKLNPKIQPYYTNLRIPTETVPWPSVPQGGVRRVSVNSFGFGGTNAHAILESFEGGGSADGSDSGFDSASTSSQAGDGDSDHGPKEVKEAQEAAVGPFVLSAHSSAALAANASALASHLRADSDKINLTALAHTLFRRTPFAFRASFSACSTAAQLASKLEEAAKSLERRTGVNSVFPEALPPRILGIFTGQGAQWATMGRELYHGASASGQFRAAIDCMQRSLDTLPAAEDRPTWRLADQLLADGGTSRVAEAAVSQPLCTALQIALVDTLRAAGIEFAAVVGHSSGEIAAAYTAGYLNAADAIRVAYYRGLHAHRAQGPGVGPGKRGKMMAVGMGWEQATAFCAEFDGALVAAASNSHTSCTLAGDADAVDKAFARLQQEGTFARVLQVDTAYHSHHMKPCAGPYLESMKECGVKLQTPQKRRAKQQQCRWYSSVWDNDDHKADGSLLEGQYWVDNLTRPVKFSQALARALDQDHVFDLALEIGPHPALKGPASETIKTSTGGLVSLPYASALKRGQNAVESLTEALGTVWSLFPSPPTERPIVTFDGVRRALQQDTTDNMEIEDLRVLKGLPSYSWNHASPIWKESRTSRLFRVGGRRGYGRHELLGHPVVYGGGARDNKREVHWKQVLRLQELPWLAGHVIQGEVLFPASGYLSMAYEAALQLVVDDDEKKQKLVRFVELHDIDIVRAMRLEQDSGLEVVLTVRVTSQSDDCITAQVACYSGPVDAPLPLDAPQTALSAHFTGGVRLWLGRSESDQEENEVLPHRNGESARPLPMDALDMEQLYSSLAEVGLQYASPFKAKAMLRRLHRATVTMSSPPESSALHACMHPVPVDTAAQGLLAAFSFPGDDRLSTLYLPTRVDCVRIIPPNSRLSASASRNENLSQQQQLTADAMVTSTAGSTIVGDIDLFDAADEVKVQIRGICLTAVGQQQRDAWLYAGTRWVRDADSGIEPERAATLSEELNVQYEVLSRASYFYLRQFRTILPQEMLIMSKSYKRNVTWALEHLLPEIEAGAHSGLPGFRPEWRDDTPEIIEALRQESISSQKSDEERYHCEMHWDFLRSVGDKLISVVRSMTPWVRIWTPHQLEWVYADGIGYSAANRDAGSLIAQLAHRYPRMNIVDVGAGTGGTSGAVLKALQEQQLQYASYNYTDISTDVLDRARVLHGHHKNVTFKKLDIDKDPAGQGFSDATFDLVIASKILHKLKSLPDALRRCRQMLRPGGQLILLEPTDDFLMSQIVKLALPDFFVGLEDGRVNGPTVDLARWDQLLRATGFAGADKTSTRTVSYCSVIVAHAVDDTIRLLREPFAATPEALAPSLGDVFIVAGGGGAITSKLASQCQNLLQAATSSKTVTIVPGLDAVSTAHNISPGSAVLCLAELDHPVFQSDEGDMAQRFRGLQDIMATAGSVLWVTMGARSGHDPCANMVVGMGSTLRAERGPSLRLQFLDVDNSSALLESSNGGPALLATMLLRLAIFDPASGDDLLWTQEPELALGGGGALYIPRVLALDAPNRRNAARRRRVTQQAVLPSRSPEAAVVLERGQEASWELKIASPPLGTSPSEGKGAVRVQVTASSLQRFTCSDGGSPSAAQALHVCIGRDVASGEKVIALSRIHGSLVSIAQEHHVLRRWPRSDKGDEDKDNNDYDDDLAWLQTFLARACASRLLLGVQGPAWIHGAPAQLGEPLDVVAREKGIAIFQTTSTAGAAGVTTFVHPYAREDDLLNLPLPEGLRTFVNLSTSQSGAAVKAICSARSIEIKQVDWADLTVGFEVCGLDHLAKNHDVVMDSGGIGESVVTLEQASAGLLPVEQELSPTAVVDWCAAETVTADVSPLEHGGLFVPDKTYFLCGMTGDMGISVCLWMVEHGARHVVLMSRNPNISSHILGYMAGKFGADVRPMAVDITNLASLRAAVTAIRADMPPIGGVMNGAMILRDRLFQNMPWDDFTAVLAPKVAGSRNLDAVLCDDEKKEPLDFFICLSSITSIAGNVGQSAYAAANQYMTGLVRRRRRRGLAASVLHIAILTGFGYIHRSDAAHAETMNRSLRTRYHNQAEPDLHAMLAEAVVSGRVRGGDGDSDNDSTTGAELITGLRTVFEGEKQQPQDPRLARYLRDDEGDDLDASAERDAAAMSVQAQLAEVGADDDAGQQRAVLEKAFAIALGKLLEMDPATIDPARPVASLGVDSLVAIRIREWMLREMGVDVSVIKVMSDTYPMSRMCDDVLVSWRKQQKKDNVTQCLNCKAERVKEGRVSELQGGTLWVEWMRHVGKTEQTEHRLQWSDWLVCVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ND38</accession>
    <name>A0AAE0ND38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_242083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ND38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3378254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="31752" checksum="3DFDEDD4E3C61394" modified="2024-05-29" version="1">MSERKVLSKYYPSDFDPSLVGKSRAPKQTGPKVQTVRLMAPFPMQCTSCGEYIYKGRKFNARKVTPVDEKYLNIQIYRFYIRCTRCSAEIVFRTDPRLQDYTVEKGAKRNTEPWRRGLQSEIDETDEARLDRIEREQVEAEGLEERNAMAELEAKTEDAKREMAVADALDEIRSRNARLEKAARDGVEVEVVVPEDDQRRRQDEEPMDDDEDVQDVVAGASSNAPLSTSSATASISAPPPVDTKPTAAVSTDMPPPSFKRIVKKKKDHSALLGIKKKQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGM9</accession>
    <name>A0AAE0NGM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_474955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGM9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="277" mass="30052" checksum="E2FD48E1E287CB61" modified="2024-05-29" version="1">MSESTTKPAKAAAKHVHHELRNINNSAAYLLPKLQAMKDAAPGGHLKILDVGAGSGTISTGFAKLVPNGHVTATDLKEDILERARTIAEAEGVTNISFQQADAYKLPFPDATFDVVHCHQVLTHLSAPSDALREMLRVAKTSGGVVAAREGDLETECVWPPLPGLIKFHDFIVRAMKGAGGTSIAGRQLLSWALKAGVDRGQIEVGFGSWGFHEADEKRIWAQGMINEVRHGRLRQAGLRFGLTESDLEEMSTTWDEWAQKDDASLGMLQGELLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGN5</accession>
    <name>A0AAE0NGN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_523868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGN5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="393" mass="42624" checksum="F566991839FE7C47" modified="2024-05-29" version="1">MAPASDAEFWKIFASKLKPNFPQGQDLGPKNCLYIPTLNERTIPAGNNVIPPITNFAIRKAADALVDLDSPLFVQDTNGGHAKRFLDSLRNVDKVSNSSQVQMATEAYNFGLLQFAYGEQSAFIQATARLESALGGMDDGQTMAASPNLDLSARTVPVEYVLKYTIDSTYNSWVASFQQPKSSQAGSKFKFTFTSEERASHRWESIGHSAAAKEEFKASDFSSPITFERTADGVQTFTVSPDGSWNPGNVQTTYPKLVVSAPMALSKPLVQVSKIVVGYKAKSRDATATANPFGFRLWLGDSSNRRLRDSDSQDESNITNWSDVVKTTSGGGYGLKIPASVDGIPTLLAVVGRAPEPLQTIFGEDQPPIHQSLTFEIGCREMGVGIAEIEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGP3</accession>
    <name>A0AAE0NGP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_545618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGP3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31490" checksum="53E6D39017AE8357" modified="2024-05-29" version="1">MARPQKNTRYALITGCSDGGLGSALAEAFARRGFHVIATLRDPAKASPALTTRPDGRIEVLPLDVTDTASIASCAADVATKTGGRLDVLVNNAGAMFVMPLLDTDLAESKKLFDVNVWGMLAVTQAFAPMLVRSRGVVLNIASIAGAVRMAWQGIYNSSKASARWISETLRIEMQGLGVRVITAMVGEVETNIYKHARAVPSLPPNSYYASQKDLIFQQGTGQMQKLNEKASVTADNLVRDVLGGRDGHVWRGGVAGRAKYLHWMAPERLFEWFLHYSRGVYQVQPPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGV2</accession>
    <name>A0AAE0NGV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_198860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="678"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1386" mass="154816" checksum="C3CE1D650121421C" modified="2024-05-29" version="1">MFSSALHEGGPAKGTRSSRRRQRPLSSDASVQQPKAKRQRVPLSETTFVNPDAPSETYDVKSDQIDLLGIKRDGIENVGVPRKELSVRSKKPKPNDRAGKGDGSIVLTSNNAYTVSKLPALPDRLRADAQNRQHGAVYSSSGYALELTHTHAFVWPYTSTTPSPETFTFALPYPSKHASDPLPLGSLVSPSASSDEPGLVVIMPVSGKIAYWESISSAATLDFIRQQRTGVEDSISGMFSGEYMSQIVNAESAGFVLVFSSGRLAYMNVRDAHGRPGISVQFLRNGLSNAGGGIFGSIRHALSSSAIRGDIAAVRASHGVNVGEKVIVAATAKGKLHSWKVHRGGHHELLTDTNSHDTLVEAIQKADPTISEFPLDSLEVIDFTFVPRGLDKKYADMSRLSEALSHAEDSIQHLLLLASFTVKRHTRYFLVEVVVSQKQGKEVKVGSVRPLTSYTSPMRTAALMKPRVYLPRPALIAFVVFDRAVVIASMASPPDSPDSQLQEDSHIIPATFEDVVDFRDEDCLQIVGSGIEEPMGHGLAQDEIRAHKSKAKNPTAVLLLQGVGTVRVAISDVDKFASEKPPEVTAKSKLEQAVFFGIRDDNPLVFQGKRDLPFSSEEIGNAAIELSHEIVSSKTPYIVHLPASLDNNMKSRVGYLDGLIGYVNALNVSLDTRTRWMLLYNAEKMAVASWIWQKHEQFLTDRPKDAKKNLICETVDYINEHQKTEPNPAIGEVDSVRHWFINDVWRLDIFVAWGYQVIKYAYTNRTTDQAGINRLLWEAVTINNGALQHAHEYRHQHARSYGVDPRKTAGGNAIPEPWTSRPFLTNNLKRLVEFCYSWLDNYATPSAGESPIDRRLLDNLKELLPSLTGQYLTALTEYSAWAAMSDDPQAQEMGKTCHQHYLSDVYEKILKLKEYGLWEEAIGLAKEHKAFNSLADVLVQQILALDQEALINGAATSKGEENFNLADVKKRRMGQLFDEYGEELAFNAYEVLLENSGIQAVLEFPYDRNGYATSFLRTRPELAKISWINDIEREKDIDHAAETLLNLGLTREQQVWNKKIELSLGKLALMAEESEQFAKGDDQSDDETRNGENLDKIDRELDLIKIQDGLYSQILPTIEEAVDEAAELELAVKEHGALIPKKFKALAQIFEDGMSRLLKHEALQPLTLIDLLTLSKLPESHFTLIGGQFLLALKVAKYSLKGEDRSNAERLIWRRNLIRDDWIQVNETNEKTDMTQLDVVGETATYRTIYQLVDQQHSDENFRPYVKPSDALGVFTDSLDRRFDKMDDTFRHRLLDAMKWEDAKLKEYIEKARLDEWYLTTRRVVEYTVANEYDRITTATTLQTNGSSLGAGFRDSLKLEAEINARFGGIAGAEGRRSLFALPNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGX1</accession>
    <name>A0AAE0NGX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transcription activator of gluconeogenesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_396880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74977" checksum="CB59E6887140DB84" modified="2024-05-29" version="1">MPDDGGPADAEVSAAMSDSENDYDDLEPLKDEDDTMAEQNLSPDGVDASGQPKKKYDPKDPLRPRRKKARRACFACQRAHLTCGDERPCQRCIKRNLADACQDGVRKKAKYLHDAPADALRPVLGPNYNPSAVPPPGPNGHRHPSNSGSEASSTVGTFFSQSNTSQFPVYSNTQTPMVTMPENVPFRSQQSPISPSFTAPGNTQMSSMTVPQVSSPMPNFTSTLFDPSNPALFNFNLEGLNFGSQYSAMEFGMLGHMSSGAAETPPHDPALSQQGGDVNFGSGVYGNGIGQYDKVYEGGMMGDFLGLDTTNANGLYSQGNLQHGLPHAYAIAAGPTSLQSPSTENNSPQPTNFGFDNSPTMATYSGTTGNGNQAINQVRPKAKSASTLAKLGAQSVLGKRQRDPSYIYESVKEPFPYVGSFHKLIQLLQRRFSQSGTLRVAKSLASVRPSFMSCTMTLNRQDLVFMEKTFQRALFEYEEFMHQTPGPTIACRRSGEVVSVNKEFTALTGWTKDVLLGKEPNLNMNLGSAGPSGGNRAKAGLTTPLLKSLNEELSKTAEGRPQPVFLAELMDEDSVIGFYEDFAQLAFNDSRGRMMRKCRLLKYRPHQEGSGGSGGSGQDESPPKDPRNSILSNRVAKIDGEHGISKLERDGKLECSYTWTIKRDTFDIPMLIVVNFLPCFYLNHNQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGZ1</accession>
    <name>A0AAE0NGZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_475529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGZ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="42134" checksum="389ED04A48AFDDAA" modified="2024-05-29" version="1">MPQDPNLYGQCPAKKQRKEMTLPGSLSFTSQLSSLMAVQNAATSTSTSTAIPGRSRPSKNKTDHLFSGVKKRSSSSNNNSNKTTDNDTNKNKNMLQLKSPIGTEDSKAELALARRKMEYKTQLYESMKRGDYVGREIGLVDFDRKWAEKHSSSNGALNQEDAYSSSSSSSSSESDDNNDEEIIEYEDEFGRLRRGTRSQKLRFERRLARGLASTTELEHMSARPKEPERIILGDAVQVEAFQALDTDKMEELARKRDRSATPPPATHYQADQEIRTKGVGFYAFSKDEGLREAEMASLDGERDKTDKLREQRDEKAAARKREIEARRKEIEERRKEIAERKAKKMADKFLEGLGQDFYAAGTDGGGGNSDGGTGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH06</accession>
    <name>A0AAE0NH06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_475271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH06"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="256"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="68206" checksum="FCBDB63FDDEEB415" modified="2024-05-29" version="1">MSDIDDELLALAGGDVSSDEEEEAMDESRSPSPAPQKAETPAQGGAANKKPRHSRSDESDEEGEASSTPGSPDSQQSVPMDESDSDSDAPETKNRPGDDELNQYPIDGLFKDYDEKENIMGMREIEREQILAERREENERIRQNRMLRQLKVNQDKDSKKRKASAAELEDQRKTSRIRTKVGETSEKMDTLRRAREERSSRKEQRERENDRRKQRSPSYRRRSGAGSEDGHSDIEWAGPNRSKQKSRTPEPREAAPAELRDIERIRLGRSRFAEVCFYPGFEDAITGCFVRINIGPDPSTRQDVYRMAIIKGFAQGRPYAMMDQSGHSMVVDLYVIAAHGKAQREWPFIMCSDREFTETEWNRYKTVAAAEGVTIPTKPALANKIDDINKLVQRVWTEQELSEKLKRQNTLHAKYSGAEREKIAKQLDMARARNDEEAVKKFQEKLDSIEVPRLAFKTSLSPQKKKSEKAGPSQQERLALLNAENRRKNAESVRKAQLKERAKTRELELRMSRGGLPDEAGRLKTRMNESVEGTPAKSGTSTPANGFGTPSLGAQQSHLLPHIAKLHEQQRSQTVSGIPMIHKPLMDDDIIGALDLDIDIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NND6</accession>
    <name>A0AAE0NND6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_448839</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NND6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3384732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="101" mass="11807" checksum="6454D6AC868D4EB3" modified="2024-05-29" version="1">MSSRQAALSLYRRSLRLALDWAVHRHLWRGQALYIRSLFEQNRAVTDPRQQRALLKETEQLLENWKHPDPYCHPTAPGGSKYERNLPVHEAARAPPPPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNH3</accession>
    <name>A0AAE0NNH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gaa1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_413559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNH3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="608" mass="67115" checksum="7CA50521A56C9AB2" modified="2024-05-29" version="1">MPRLLAGALRLRRDPRILKLPPYLSLLCIFVGVVWLLLLPLNDYSRRTYISENALLPGQVHTYFGGSDQNVFRAYKHEVNALVGKSNIEINDKLESIVKGLGLKVACQNFTYTSAGRVYSGENVYAILQAPRGDATEAIVLVAAWENVQQEVNRNGVALILTLARYFKRWSLWSKDIVFLVTPDSIAGPQAWVDAYHDAHDSARVDSLPLKSGALQGAIAIDYAQEGRFESVHIVYDGVNGQLPNLDLINSVVSIAGGQMGMGVALQEMWQHNDQYPDRLRTMLRGMLKQGLGLASGPHSSFIPYHVDAVTLQPFGDGWQDEMAMGRVVEGTFRSLNNLLEHLHQSFFFYLLMQRERFVSIGTYLPSAMLVAVNFTIMAIALWVKSGQPESSNNTPTPPASEGETAAPAASNPAVERDIFLPLGVVTLCQSVAVIPLYLFNHASESLLTPFFVIFALLNPLLPLILSNFLTTTYRPTTQQYQLIKSFSLLLLGMFLASLATLNFSLALLVGVLASPLTFMRPWPNSDAMRIACTVLLNTVSPTSVLVASAAYWQLDIGTVLREAAFAWHVCGMYSPVVVWCVWWPAWLAGNVIVLGRPDESKGKEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNM9</accession>
    <name>A0AAE0NNM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_172574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNM9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3384867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="68088" checksum="C69090CC50D3F73A" modified="2024-05-29" version="1">MLPQRRGRRTTLIALVVLVALFYYFSFPTRTQTQGSLASESILLERHMNSNSGRTSSLKSNSSFDWSKVKFKHPPGRLRTLPSGRPVSLPPVQYSFPPETPTAAKTREARRLQVKALFRKNWASYRKYAWMKDALQPISAEYKDQFSGWAATLVDSLDTLWIMGLRYEFDEAVTAVANIDFGKSSTATVNMFEVNIRYLGGLLAAYDLSKRKVLLTKAIELGDLLYTGYNTANRMPVDFINFESAQAGEGLVVESSVVAASPGTLSMEMTHLSQVTGDPKYYDAVSRVMDVFEKGQQFTKIGGLWPIYVSMSHQDVVNGSYFSIAGGIDSLYEYLPKMHALLGGLEPRYQTMSEAFIEAANKTFFFRPMLPAEEDLLMIGTARVEDDAKNTVVMDPESEHLGCFVGGVYSLAGRLFRRPEWVYDLGYKLTQGCVYAYRSMPTGIMPERYNMAPCSSRTSCPWNETKFVEEAKKQPLWASHLPKGFTTARDPRYLLRPEAIESVFVMYRTTGRKEFQEAAWDMFVSVANGTETKYANAAVLDVTKAVYPLPQEDYMESFWLAETLKYFYLVFSPPDLISLDDYVLNTEAHPFRRPKAAATSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNR5</accession>
    <name>A0AAE0NNR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNR5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932278" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="87" mass="9660" checksum="66E15BFA8DA3C029" modified="2024-05-29" version="1">MKLRVESALHIGWLIAGLRFPSQATVLICSNDQCPAIVTIHQTCRFFLEYVSGHLGSQILSFALGNAVAKTSSLDYFKWERASRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPH3</accession>
    <name>A0AAE0NPH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_543617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPH3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="556" mass="60089" checksum="493CBE18644D2946" modified="2024-05-29" version="1">MAPSPLQNAAYYTDHQTRCGGNASQVPLATTPNQRTVPLPPPLPSPLQGQTNIRNTLPNSQPSQQPERGTSNELESSTNSTEPSQLSSHFSRVGQLVTTAATSIHSSSGALESYGFEVSVLSGQLSTFKRYITRTLYVGHPDEIEVPSPVLARWESNIRDQLRIDLADVISDIQRRGALKRVQDSECNVTYELRMSGYAAKSSDVVTLSPCIWVFCGSKWATNAVRKAVKDYTWLSTFAPVEVHVGGAVLAYTLAAAADIKGLDYSHRLTVGDRCNLYINVQDYGEGSSLCGLICCATLERGSSVVHHISRIGGSVSMTLRDGGFVKSGISTAHGVLGLLDDLMVHRLRLGDVKSSISNMSKVGADGNFESNADEDEEEEEEEEEEEEEEEEEEEEEETDPSRDALPLITQRLGYLDPGAVAKWTNHSFGTSFSFSGPSLTAAPTADRSIMEGSSQLVRLDGTRPTSAQTDHMLTPLSPRAFLNLNTTNRYTRPGGGPTDVVRHFADDNLHKGAVSILCGEGDVIGGVLIASTTNLAVRGQTFALRKVRTPSVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPL4</accession>
    <name>A0AAE0NPL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_395562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPL4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3385170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="572" mass="60783" checksum="263A2857184EA864" modified="2024-05-29" version="1">MATAGDANLGNPDTTTTTAIDPAAGLPAKNDVVDDTADEGDTAAPVKYNWRFWAIFASLVAATLLSALDGSIVSTALPTIAETLDMGPDSVWVANVYFLTGAVFQPLFAQLSDLWGRRWVFLSILAIFTLGSGLCGGANSAGMLIAARAVQGVGAGGINMMVDLIICDLVPMRDRGKFLGMIFMVIGLFTAVGPLVGGAFAQAGYWRWVFYINLPIGVPCMVVTFLFLNVKSRASGDSFVAKMRRIDWGGVIILTISTLGVMYAVTYGGSLRSWSDASVVAPLIAGLLFIIIFVLYEGSSFVAEPVTPYHLFANRTSAAAYAISFLHAILGLWIMYVLAVYFQAVLGTTPTLSGVYMMPTVIGFPVSAAAGGIVMSKIGRYKPIHIAGFGLFTLGSGLCSILGPNSSPAAWVFFQLFMAIGLGLVMACLLPAVQVGLKESDTALSTGTWAFIRSVGVIWGVTIPVAVFNNRFDELLPQVVQDEGARLLLGNGQAYAHATAAVVNSFAGETRDQVVDVYSRSIQRVWQIAVVFGGVSLLLALIEKEESLRQNLDTDFGIEDEKKKTVPAEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ17</accession>
    <name>A0AAE0NQ17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_543726</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042066574" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3385410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="257" mass="28410" checksum="8055E0F4FD322836" modified="2024-05-29" version="1">MAGVIVPLLLAVLAALLPGPALAHGGIANYTVGETWYRGYDPDTPAADQVGQSWMVQRPWASIDPIFSVDDKYMACNKPGAPATSYIPIQAGENITAVYWYWLHPTGPMTAWLAYCGDGADSHDCSDVDVNEVQWFKIWEAGLLEGPNLAEGLWYQKNFQHWDGSPDLWPVTIPASLRPGLYMIRHEILSIHIENKPQFYPECAHLNISGSGTAVPSKEYLKKFPGAYDANDPWININIYDSNTTDYIIPGGPVWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR09</accession>
    <name>A0AAE0NR09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_473768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="654" mass="72536" checksum="E4C1E67B7021335C" modified="2024-05-29" version="1">MLPDRDLLREQRARCGWSPGLRAEHLSPVMLKNDPRISFKFNGSLNVIEHDGSLSTDYSLSETLLFKDACAKREADFFELAGDDLALPLISRIGWVEDDLVTFRQESVIIERGIPLLVSEIQPTERQSVSLQIAALVSRMHANGIVHGNINPGVMHWNAKGQLVFSDFRHARLANRGRDAHGEVRGSAINSGFLSPRFRSRTRPGRGVFPTEIDDLYAMAVTIWCVWAGQWPSERMFSEEGAPTFDLSVITDPDIYGGVVDILQQGGLSLDTTVLQRSPRMRESSPPASSCGSQDHERRTSVASPYSGVVEGYQWTTPVNLTQDSYCTQPEAARTLQLLEGPAELPADVPNTPSVQPAVLASGDHTNTALGHDTESIVKLTGRPESCLQMHDFFSRASLSLDTKARPVSLWAQQNTQCWFTTDYFSAESEWAPCASPQEIGELHFVEHDLHPREHDLNSQSTSDNDDDEDDDDDDSIRDEDDDDDDDDDDDDVEDDNITWEFPAPHLQGLSLPPPPPQPPQDLTALTPRTADDVFKDAFSPCFQTSFGGRQGDDEDFSPHLQQLHTVMTFGPKKMRQAMADSAKPDHGGQQQHATTSSVETDWNNLNGVKLNNRCGGARTRSTTSGSVWRPTKCGEEQGADHRVRSWSGSQWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSU3</accession>
    <name>A0AAE0NSU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_508954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="16"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="502"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="728"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114015" checksum="D9516C9D317C602F" modified="2024-05-29" version="1">MRVSSDTRLSSPGLVLKFGKQIQKRQLEVPEYAASFVNYKALKKLIKKLSATPIIPTQNDLHRAAAEHLDSQAALQANKATFFFQLERELEKVNAFYLQKEAELKIRLKTLLDKKKSLRSRNNGVSRRSAKFTTLQEGFQQFTNDLNKLQQFVEINGTAFSKILKKWDKTSKSKTKELYLSRAVEVQPFFNATVISELSDQATTSLQELGAWVEGDNVSFEGRPDHIVSSQHLLGTDEGDADTLLLDTVLAGHLDSLRDLIGRMRAAADPNNTNTIDVSLMERITRTFLASINEGHLDALRVLLETGLVEIQSEDDINERNCLHQAAIYGNSFVLEFGLSQGVAVDRTDVYGRVPLHYASMHGRLDMLDALLSAAPQTIDLIDHDNFTPLVHAIVHGHFKCVQKLLEKSARIDPVSDTDHVPLNLACEHGTIAIVELFLKHGARILPDAEGLYPQHLVARSGQTPELLLLLKSYGADLDQIDKLYGWTPLVHAASEGNVPCLQALLGVGADPNILDEKELPAMYYAAWEGHLECMRLLALFTRGVAPSPLAMQISGSLAPMGSSSSPMPMSLDPDAIPVLELPPPIIPLRRYGHNFLDTKTVVQINFEGDQPLVFFHDSKYPAARLTISSKISDLIPKNIMLPFQEDTRLVSFQIDNLDSFTLDFDVFPAYGAKVIAKTVALPNTFRALLSSSGSCCLPLFDPRLRAIGQISFHTQVIKPFRGKPLEITDFETYWKATSQLDRNMSTFVTGSSLSGDFVRIFVQRTSDGVPVLWPRWTISCGGIDVPVSRLTFEQFSTVTAPARSDPNFLASLPSYPPDGIASIHRILSTAGITLHDALSLLPYGMHVNIQVLYPTAEEERYFNLGPSADINAFVDAILTIVFDHARAQRAHSADGVRSVVFSSYNPSLCTALNWKQPNFPVFLCNDLGKHDVLGDSGPQSISRKTSSIKDVVRTAVSNNFMGLICCSSLLDMVPALVDAIKSHGLALVVDKSGEKLPEFINSLADPFPRLPKGVDGLLKDNGVLRFNESIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTD8</accession>
    <name>A0AAE0NTD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_469859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="72082" checksum="36E5CF127157C951" modified="2024-05-29" version="1">MVGTTLIGDLDSESRRYRSHFSERFTANPGPWIDYRAAHTSATAPVDELTVECICCLDDIEPENAIETGCHKHCKQCFKRLIALAAKSQSQWPLRCCSDPIKFETISKHIGGELLNLCREKEEEFVTSEVRRWVDMINQGGSPRAGEMFRIDRAFEFAKIERFESPRAKQLLKLVVEPKRAWESRFDVSMALPRVTTGPLYNIMGRNKFSETTRGFLNKCGGAVMFQMPPAYEGKGEMREKWPLLNKNLRNNARNKGDPELQSASRRFFDDTVQQPLEMKNGAGKDISTAPYFSLIKELDSFSPICLEAKRLLVKASASLPWKEPDEIQPQQQGRQLNVLPRTHGDQPSALVESPFKNDPGTHQVSPESDVSVRKGPVVYGTERDAIHDAQTAPAGPRPSQKQGQIDTLRSDVEHAISCGQYDPSTTDSWGAWTDQISRLRRAIAPILAIDKRLLFLYLASDIISPVAATPSNGIAPPPDTKHNPWLVGLLGGLAMTSFLTGMAESMLNSDQLPGRIALSLLSYASLGLLTMGYSLAFLTTAVQAGLFAAGAVPVGLLFWILISREQPSAGMAGNNSAAWLRNFNGIGLMAVLAGILNTQSRLIGACMAELGRIRHINFGGDRSIAGDEESGELVPMRPSQDDASAPSADDVEPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTG0</accession>
    <name>A0AAE0NTG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_392804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTG0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="26138" checksum="25DACE61F14F41EA" modified="2024-05-29" version="1">MSLTFSGCTVEDAAALAINNAGAFWGQPYWRMIWPADAQLSYITEQLKNRIAARVLLIDRDERRHEKAVDNDTGAVVGYARWLLPPALQSEWTEAQVPDVDDKAKKVFEELADSAVWNPGAGTSINTDVLDAKIASTKQRILAGREFIQLDYLAVHPDSQGRGVATSLVLRGVRQAERLGWPIFVLAFDVSRGVYLRQGFREVEQLLQDDRPYGGSGNYNTYFLVYEPASSSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTI4</accession>
    <name>A0AAE0NTI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetaldoxime dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_558938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTI4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="364" mass="41058" checksum="80C20FB5A6936798" modified="2024-05-29" version="1">MLVSSIADHMQCPRTRPAQLPNPDFQPQYPSFSIRFPENISQLVMAVIGAQHKSASDAADGASRATLTIFLTSRASTTPPSFFEWTSVTDNKGFYNIAALAYWPSKTAYESWAEESGFKAWWQALDPDSPNGWFLEAFFPTTDRFETLFNTDTAREGSAHMGQCMSEAVKEHGYWGSMRDRISLSQTDGLEGVKAVPDEYRSPPQDVTPTGRVIIPGRKNLAVIRSGQDWLDTTLEERSLYLDTMHPVLTKGMEFLRDHGEEVGCYSCRFMEVVDLKTAKPEGIDRTFGLAYFDELASLEKWCKEHPTHLAIFKGFFQYAKKLGNNVTLRVFHEVMVLQPEQQYFDILNAELYSVLVSVAARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU84</accession>
    <name>A0AAE0NU84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_391673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU84"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042120953" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="317" mass="34929" checksum="EB917E4F94CA8570" modified="2024-05-29" version="1">MKFLQLATLIGAAAALPSESHSPRQTCTSPKLRKSWSKATTAEKTAYLQAAVCITTKPSKLKTYPNATLHDDFAYVHARLSAPQQIHFFAGFLPWHRFFVQVYEKALQDCGYTGTALYWDWVADSSAPSKAAVWDPVTGFGGNGVDTGDNGIRKRVIDGPFKNYKPLYWNADIVPHWLSRDWLPGQDGQPEIGGAGYGPAAMADVNAQTIYDEFRGQLEDGPHAAVHSGVGGGFFGLGDLDPIFFLHHTQVDRLWWLWQQRDPRNRTFAYNGFHNTDDGSPGAAVTLNDVLPMGGLAPDGIVRDYMDIKGGKLCYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX00</accession>
    <name>A0AAE0NX00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_463296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX00"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042013931" evidence="1">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="138" mass="13440" checksum="0CECC6DEE7331D34" modified="2024-05-29" version="1">MGFFTNIMVSLLATAVAAVPQTIDAFAGTGLDTAIRAEVTATPTLVSVSGCAAVVSTTDICSTCFTADCVVLATITVNTDCGCPATPVTIYSSHPCDLGCDGLGCGTAYTVVTTSGAGACTQSASPPSASATTTGAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXS3</accession>
    <name>A0AAE0NXS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_499644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXS3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="55083" checksum="91A327F3B1413C67" modified="2024-05-29" version="1">MSTVEESTSVGRSFDTKWVKPARAYMIMTHLTLVIFMTSVTTGLVTTGIPTMAQDLNIPPQTMYWPLSVFSLTAGACLIISGTVADVVGSRRVFLTGTFLLSMFTLGCGLAQRDIQLTMFRAFQGISVAMCLPTSVGILCHTIAPGRLRNVGFACTGLGQPLGFSLGLVLGGVFINTVGWRPGWYFAAATIFVCFPIGLLVIPVDVLAVPPSFKRLRTQVDWPGAIIASACLSMLSFVLVRLSEDQCNIHDHTVIALLVISVILMPVFISWMHLAAKRNLPVLIPNEPWRRISFSSVCVMVMMSYAVIQVLELYCTLFFQKIQHLDALQSSIRLLPSMIIGAILNLTVGLFIHRVSAMWLTFSTSLVCAGAPLLMALIDPLWPYWYAAFPAQVLHPLSADVLFCVGLIIISQEFPEDTKALAGAVFNTMGQFGTSIGLAVVGIIADNATQKTPCDDKTSPPALFEGYKAAFWTAFGLTLATAAVSIIGLRKIGKADTGQRKQNSEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY06</accession>
    <name>A0AAE0NY06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_445993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY06"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041943563" evidence="2">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="222" mass="24012" checksum="167DEACD0490DE60" modified="2024-05-29" version="1">MTRATKLFLLAAVLSTATASPIAPANTDGIELSERSPPASSASKVMILAARGEPPLLERTWLGGVNPWLTTARKEELRNPSSSMKKPKDPGTSPPAQSQRRVKTRRSAQWWGCSRSSPHEEDEENFHWRKESPDACDNNDKNPVIGGGQNHHHHHSQQQTPNGKKKPSSSSKPSTKPKTTASGKHHKPNTAAGKPSRSKLAADRKKTSKPAAAKPKPEPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYF7</accession>
    <name>A0AAE0NYF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_105733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="430"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="363"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3389941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="660" mass="71122" checksum="61DD58912FCEE8BE" modified="2024-05-29" version="1">MSMASSIVDSEESVTLEFVTTPTTPDSSQCFTPGLPFDDNLADTTIRVRTNGKSLSSSLFDTTTRTPPVRNICCVGAGYVGGPTAAVIAFQNPHIRVTVVDRDEKRIRRWNSQHPPIYEPGLNDILRVARDGSRQCIVCTESECSDGSSQCGGNGCASTTVAARLPNLFFTTDVAKCISEADVVLIAVNTPTKSRGTGAGSATDMAAFEAVTAVVAQHARPGAIIVEKSTVPCRTAELVQDTLSLHRPNVHFEVLSNPEFLAAGTAIKDLLTADRILIGSSSTPAGHRAAAALASVYASWVPKSRIITTNIFSSELAKLVANSMLAQRISSINSIAAICDATGADVDEVASAIGADSRIGSKFLNAGIGFGGSCFKKDVLSLVYLAETLILPEVAEYWRAVIMMNEYSRNRFVARVVRCLNNTLSGKKVTLFGYAFKKDTNDTRESPALDIIRTLAEEGPQEIAIFDPCCIPAQMEDEIRRFVGANFLKADGGPVAVYGNAYAACEGSDAVMITTAFDEFKNSATGEITIAGRPKACSVDPRPFEHTEPTEGDLLALHTYLQRMVTPATPVASVLDPLDRLNPFPTCTEDCPDCELEKATGTTGYGAGEEYVPKARLDWRKIHYHMRKPRWVFDGRGVLDISEMERLGFRVESVGRQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYQ3</accession>
    <name>A0AAE0NYQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_390151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYQ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="671" mass="73333" checksum="C1009E30C58BFD8B" modified="2024-05-29" version="1">MYLFFVIGAGFAIGHHVFYSTLNGKPATDQIQMLRYGTILAFAAKAGLSAAVIIGFQQRVWTTVRRRLMSIAAVDSLFSATDDLTALWNWELIKNAKVAVLLAVFAWLAPLMIILTANTLLVEPAAMMTDDKCPGVRSLNFTFEETNEWRDPVKIGQLFEMPLSFWNTTKPSNSDPPGWFDYYTGPSPIFFQTASIGAYMGREVMRKNAQVETCGSGWNCSFEITFTAPAYKCTELASGVGTKPANLTQESGSIAPPFDLDLILPTGRFSYYAFTSGGEYSSTQMRDVSSGGIPNSPPPYPKHLGAFRTEPIIWIGYASIADPDKPIPNSPSDPAWATAFVPKLFACENYESSYTVLFNFTEGTQSTLVKNITFLHPVVNTTFLPNIDADDGTADNVTATPEANYILPADTHRYRRTAAFHSLGQLVRYFLNGTVEMENSLVNPIVNTNALQTKLLDPRTNYFPHPDLATVVQHFYADIILSLLSSPQFAPVVWAARPGEQSGTLLQGGLPDNKETYLYPCDKSRTANVYKYHVRDLWIVYGIAILLAAAGIIAGAVAVGENDGAMRDTRFSSIVAASRGPALEKVAWASGVPGRGVGGNDAAAHTVPKEVKGLRIGYGLVPGSGGDQSDETEGWRRSTGSQVRYGFGLEGDVRQVKREGNMLRFTVLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYU8</accession>
    <name>A0AAE0NYU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10408" checksum="E7DC407E1C14F04F" modified="2024-05-29" version="1">MADHGNNNPGNFANRTNTGGLGHNNKEDNPGNFANWQDELREVAAKGGKASHGSHSTEAAAEDDDTSSSGRSTKNTNPGNFANRPKEEVQAIASKGGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYX5</accession>
    <name>A0AAE0NYX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_538547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYX5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="300"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="49916" checksum="1A5B8AFF4F081BB2" modified="2024-05-29" version="1">MHPDVVSSLAYSFATKCEESFPESFPERYLDSPARSPGPDRSAPQSHAGDGILYTQPHPVLPRPETFQVEPGLSSFWSQSWLEQSQHVPFHRHSHHGPRAASPPALVNYGIFTSPIPPPSPAQTDWDMLQTTFDQSSSISAAVERFQWAATQCSELKIEDDSDSILSLNDSLEEFCPPQSAWPPPATQRFRRRSVPKITKPSRLMPPTAAAAALSRPNRRSTYNNNTTHHQHQHQPHHDSSPDNLFDLSEVLLPPSDYPLPQPTSAATPATDHPTTPTFFAHPGGGGPDDEFSSTTKALSKRIAHKLSEKSRRNRLTVAIREIQRLLPPGAPPDRTITENPNALTPSSPLQADESQRGFVSTASTTTTVGGSAPISKVDVVEMAIGYIKRLQKENEKSARRAEEAESELREARRQKEVPTSPIHEASVAVEEDKPSENNEDDGARMAVRKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ70</accession>
    <name>A0AAE0NZ70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ70"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045764" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18166" checksum="4D774D1D829EB455" modified="2024-05-29" version="1">MFTRVTVLANLLAAAFATPVANLTPGPVLDEREVPLANLTLVGRDEIDARGKLAKHAEGVHLVDCGGVYSLVVYCANDSNCSFFPSGSNKCVPPPGGLTTWAAHPGSCTFSTGVTFLWNLVSNAQTYPNYAVVGSASNGFRSFTCRKDHKHIMFYDGNGYSCRSIYYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZE0</accession>
    <name>A0AAE0NZE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_117193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZE0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="83072" checksum="8D127EDDF1FE2E3E" modified="2024-05-29" version="1">MGESDDELIEDRQLANLEANDIGIQVTRRLAVPPDLYGVRIRTVSSFADQTILDTYIPSSASSPLNDPQTAAVFWYFVNVTGPSMSLYERHPFDPTPMFQGEPVPKARQHIWTYTFPIVSFQHPALMQAMLALGSLQMAKLQGSPAIAAMKHYHLALRRIAKNYQSYSRRTQPATLAATLLLGFYEVWNSDHDKWCKHMWGARAIFREIPLKEMTREILPLKRKRWQRLLELRAQQVDGYGNPLQPLTDPEGDMVDKEFITQLTGHHVTFGEEGHVLDDESPRPSARKYTERDIERYEHLSDLYWWYSKMDVYQSILGGTRLFMEYDHWTQCAPRAQFGRIDAIYGTFDHLMLLMGRLVNFASLDLARKRKARRADAAAGRGPGQGQNPPHGQGHPYGHGPPHAQGPPHAQGPPHAQGPPHAQGPPHAQGPPHAQGPPHAQGPPHPQGSSHSQAPPTPMFVGMFPTKGFTKPEGFSPRRESSPTASDAAEDIDLETSTAAAHKEWQAILLAFESFRSRLGPDFEPMGPEHAPPEQTPFGPALKYRTYSIAGIWLNFYMGLIVLYRAHPSMPPFSVVAAGMAARQTAGWANEIGRIAAGLHEDSNSADAISTLEGAAFIESCFCLFVAGIQYQNEHQRHWTIRRLYDIGRLTGWQSARQIADGCESSWLKAAELGRGPPYHSPPELGVSHPESIWMRPRRIDRRLQELEAGDNKLILAKTEQAHYALGLLSVEQDLETLDLGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P030</accession>
    <name>A0AAE0P030_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_519996</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P030"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="52873" checksum="115915605AAF243F" modified="2024-05-29" version="1">MAEPTTPTTSPASTEPLPKPPKPRNQALRMLGLPALPKKLPSRNWSIFWSLTIGITGAIIYDRREKRRNIAKWRHVVEHLAKEPLPDGLAQPRKLTIYLSAPPGDGLRVAQDHYTEYVKPVLAASGLDWEFVQGRREGDVRAVAAEKVRKVRRNWEGNNEEDPNRPPTEEEIVEAIRKSRGIEDYAGIRGDVVIGRHTWKEYLRGIHEGWLGPLTPPAAPEVPAAPAPESDSSLSATSDFASEEKPAEEKPVGEKPVEEAKPKRPPQPKPYNTTNDYITESLPRLAPNEFTPVAPIREPHILGFLNTPLRMQRFFNRRKLADDIGREVAAVCLCTYREFQQLPAEEGDATEPEQKFEQQNELAWEEKDWVKTVWKEAKHSTEEGVAPEEPTERIRASPIVMDPRIATRMRRFELLPEDEERVSKIVVPETEVEGWTKGKLRNLYRWGVDKATKPKKTVPLDDADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0R2</accession>
    <name>A0AAE0P0R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_467396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF30">
        <property type="entry name" value="ACETYL-HYDROLASE LIPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="98"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="36196" checksum="6908AD30918E0E4F" modified="2024-05-29" version="1">MVSLTDGQKATLSPEAAAYLTNIHHVPFASFLSPLLTSSSRIPRLRQGYQQKMGPAETELIEKHHLRMTDIVVAGVPVTVIEPPSIKPEEQQKALFNVFGGAFVMGSPRDRAALTMAAELSVRVYSVGYTKSPEAKYPVARDQCLAVYRELLRLGPPGLAPLDPANLYAMGCSSGAQLLVSMLLVAQREGLPMPTAGLYLCAPALDLSGAGDSMASNQHDRDLMPVSLLIGMVSQNYAPGGVDPRDPLYSPIYADYGPSFPPTIVTVGTRDFALSHGVRFYWKLRQAGARVELLVSEGMWHGFNWDPVIPEALQVRAAVIEFLEGPKAAGNNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0W2</accession>
    <name>A0AAE0P0W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_364814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="53" mass="5971" checksum="95DC59B1E5EF3F77" modified="2024-05-29" version="1" fragment="single">RFGYGFSRDLSWITWHGHNLLWLPAEFRPGKSAISGCTAVIGCNSGRAIFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3W2</accession>
    <name>A0AAE0P3W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_2282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="256" mass="29147" checksum="024585AC02D630CB" modified="2024-05-29" version="1">MHPKIWHLHALRIRLDQNLGFRPSFFSKLWFDHSFATGIPLSCRFLCALWGMIYLQIFERQERKTTLPNSDSEISVRKSVLRVIIGLFWAAVVFPLVDWRLYSWLVRWLDGSGDAIWNWTSWNRRRAHAPIFALTVAGAQVPQLGNSIAYLVLTNRSLHGPGDNALIYVVRGSAVGLAVLSLVTACLIWARLLTAVSLPSRILPPRSTPDEPAYVLNRTPDDIVLTGYTWPRDDNNGKNDVRTLALLYNKQQENVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P462</accession>
    <name>A0AAE0P462_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_443191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P462"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21221" checksum="F499B856C94953AD" modified="2024-05-29" version="1">MASPALPREVLNFAIAYCSDLRNCDIFPRFQTILYHKEVQMHGPDAPGVSSIYWALYVYNVDVLRWACEVYKREKAWELLTGQNINLREFYRIKSCDINMSPVMMAVELGRLDMLKILIDHNANDEQDGKWNLLIVNMYKVPGLRKSWESCVYVPAALSPASSFMVQNRVTPAMVPMGCPHSTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P503</accession>
    <name>A0AAE0P503_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_458503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P503"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="212"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="42033" checksum="0D932C5520F936E6" modified="2024-05-29" version="1">MSSIGPQLPPHLQKRKRTPDEEDAATPSSPPVKMTRRSSDNNSDDDEFRPSAPAPSTGRGTPSEKKPSIGPSMPPKPANSAGEKTTSPPFHKQAIGPALPPPAPSNNDEIPLDSDSDSDIGPSAPPKAASTKPPAVRRVLGPAPPPADLSQRPTTGPDSDSSDDDDNWGPALPSVTASAAQSSSSTSRFGPYFPAESHPAGPAKRDDWMVAPPTSSGYSVADPTKLKSRKFASGRSVADKKPGGSGPSSIWTETPEEKMRRVTNAVLGREDPAASSEPPAASSRQSAHLVGTRRVDESRIRSYTEETRGRSLVEEHQALRNAAKQKKAAAPAAGKKRQAVGSDGEEIMIEEEDDPSKRAFDKEKDMAVSGHISGTQRQQMLNKATDFGGRFQKGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5G8</accession>
    <name>A0AAE0P5G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA-repair protein rad13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_498789</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="901"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="520"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="690"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="838"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3393798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139699" checksum="7688230EC907EBD9" modified="2024-05-29" version="1">MGVNGLWAVIQPCARPTNLATLNRKRLAVDASIWIYQFLKAVRDKEGNALRNSHVVGFFRRICKLLWFGIKPVFVFDGGAPALKRATLQGRRRRREGRREDAARTAGKLLAVQMQRIAEEEEGKRKRRVEADGTVGADGTVGASEVEEEEQEQLPDLDQVVYADELGLSKQERQKSRTFRKQDAYHLPELENGIEAMGKPEDPRIMSVEELEEYSRQFNNGEDINLYDFSKIDFDGEFFMSLPPADRYNILNAARLRSRLRMGLSKEQLDDMFPDRMAFSRFQIERVRERNKLTQRLMHEMGMVGLDLTIGGKARVAGEKNREYILVKNEGAEGGWALGVVSREKDRGEIHKPIDVDALDFQYQAKEEEEDSDEDIEFEDVPIEGVNRLPKLSTLRGVAEADDAEESLFVDNDDDADLFGNDDDSMQADEDEDLSRAIALSLQNQHGVGSQDEEEQQDVDDIPAPVWNQKAAEPARPIVSTGSGRMVAHIVNNRASAAVPRRRDSGSSDSDMDLQAAFAAARKKKPVQKPANPPVAKAPVRPNVKNPFDGPLPFEKLNWQNMFSAMKQPTTVKKSEKPKEKETDAMEAESDDGAGGFERAPSQGEKETAAAPEQQREDAPRPLPPWLADNTDIRDSVKRQQELDREMAAEDEEMAQEELLHLRQQREDAIVHIDSSDDNDSDIEILDAPPVRLSRQPAVQQQPGASLPSFDDDVDKGVTEESAMPENGAHSPFEEDILNGPVSVTLEPPRRSPSPEDDPNVEFEDVAIPDQRISSFARPSATQESEVARIEAELFGDGTHLTVDQDGTAPAEDDLFAGLEAPAAEEFDFSDPEEEELLAQMAEEVEEHARFASELNNKPQSVSREAYEQELKALRSQQKKDRRDADEVTQVMVTECQALLRLFGIPYVTAPMEAEAQCAELVRLKLVDGIVTDDSDTFLFGGTRVYKNMFNSNKYVECYLAQDLEAELSLSREQLIAIAQLLGSDYTEGLPGVGPVTALEILSEFPGKEGLEAFKDWWQDVQMRGRPKEADAASPFRRKFRKSQATKLFLPLGFPSPAVFDAYLAPEVDASPERFQWGVPDLEGLRQFLMSTIGWSQERTDEVLVPVIRDMNKREQEGTQTNITRYFEGSVGTGAKEAFAPRQRAAKGSKRMADAVSKLRQAAKSGPNGMGSMSTELPVKIYDSGPKTSKKRKQPVVVLEEEDDDDDDNEHEALDEDDGSENDVRGSGAARKGGGKARAKGKAKATGKRSKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5J7</accession>
    <name>A0AAE0P5J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_388311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5J7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23952">
        <property type="entry name" value="Utp17_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="625"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="972" mass="105541" checksum="B0CC8128EBBBB489" modified="2024-05-29" version="1">MGSRMDANGDTASLKKRKREQKDDALLSLKRLRSKSKSNSQVNGTPDKKDPQPNDSPAKDTDGDVELPDASLEASTELVRTSETERPAAWKVSKPMGGRMLDIDPIFSLDERRNLIITYNTSIQVYSTENSLLVRRIALPITRLDNGDEPTSAHIVASSLSKNSPDHIWVAFSDGRVWNINWATGGGADTPFMIDAKKIIDMAVESVEIGNIAQDVLLILKKLTYSSGQIVAYDNKALSKNEGHLLHTYDESPQLLRSTVGGRLIVAAAKEALHVGVLGSHKNKKHASLNDLAYHFHSFAAPDTITCLDVKPTVQTNKKGGKEIQCLDLVIGCARGAIYAYNDVLSKLPGGGYGSSSAKAIPFQPRKYHWHRRAVHSVKWSEDGKYFISGGYETVLVLWQIDTGKKDFLPHLSAAIENITISHQGSSYALHLDDNSAMVLSTAEMKPTMYVSGIQSLVLGEHPSKDAVVKRVWKAVEEISMPLVTASNPRNTSQMYLCVGNGQQATIGGGVPSTPLVQVFDIASFQSVSKHAIARTNPTEANITTQGVPIIEPRVTKLAFSRDGQWLASVDEWQPPARDAETFLTGSKTTADVCQERRETFLKFWEVGEDESSLELVSRINEAHHTTHSEAIFDLASDPTSSRFATIGSDGMVRFWTSKLRRRDGLASTGPEGQQLRAWSCSRTVSLPLHGQQADLIEISTKKARSGALTFSEDGSVLFAAFGASSEAVVVAIDTETGSSRDVVSGMFRGEVRGIKALSSCLIMLSDDLTVYDIVSDELQYSFGLKDTSEAAKRLTQLAVNYESRSFALVAPVPIPAQEKLTRGAKSELLVFSVDDSEPQLVQTFPQLITSVFPAPASSGFVVVDSKAQIWSVTEGSEQAPLLQPLADLGVDGDAGVAPLDVMQDGGEASDEEMEDAGMDVDMEEDYDIHTAVVAPQRLAEIFNAAPAFAMPPIEDIFNQVAGLFSTKPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5N7</accession>
    <name>A0AAE0P5N7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_17746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5N7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3393435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="30592" checksum="CB73C37EA96C75E7" modified="2024-05-29" version="1">MLTSTATSMIRTSARSGLQPILFRSAACPYAAGMTLSPFSMAAAAPSPSSKLASAHARSSNPSKQTQAVPQARPLSTSTSSSLLIRFRTTATQTQRRNASSSPNGPARVHGSDAEVDANAAAAAAAAQTAAHPEASALDWNTFFQLRKTRRRWQQAFSVVVALASSAGGALFLTTSLGDQVVGQIPLDPFITMGLVTLSFATLGWLVGPSMGTLVFNSLKRKYKGQMAIKESQFFARVKKHRVDPTASSMGNPVPDFYGEKISSVAGYRQWLRDQRAFNKKRTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Q6</accession>
    <name>A0AAE0P5Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_28303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Q6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="327"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3393794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="537" mass="58094" checksum="64F0FE6F4A9FBB7C" modified="2024-05-29" version="1">MGNQASKDAGVGSSKSAANGSGPDGLQSYPSFSRSDTKDSSRSFRSLRSKIPGSGKTDSPRSSTILSNGDLPEKSDAASVKSGKSGKSGLGRPSRSDSVPTPSSPSSPSSVDTATSPAADEQPPPSPIQSASMRAGVHDVSAAQASGEVDHVSDQPPSGGGNPSLPGQQPGQSILVKRENTINPISTMRTSEDSISREDAAAAVTMSEIKDIDLDDFIKRLLDAAYAGKVTKSVCLKNAEIAAICARARECFLSQPALLELDAPVKIVGDVHGQYTDLIRMFEMCGFPPNANFLFLGDYVDRGKQSLETILLLLCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNVKIWKTFIDTFNTLPIASIVAGKIFCVHGGLSPALGHMDDIRNIARPTDVPDYGLLNDLLWSDPADMEQDWEANERGVSYCFGKKVITDFLATHDFDLVCRAHMVVEDGYEFFNDRVLVTVFSAPNYCGEFDNWGAVMSVSSELLCSFELLKPLDSNALKSHIKKGRNKRNNMLNSPPASVYPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P781</accession>
    <name>A0AAE0P781_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_53645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P781"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="426" mass="46512" checksum="63F5BF9ADE076FCB" modified="2024-05-29" version="1">MSSTTDLLVGSFSHLKDLDREKDALHTLKKIASLVKPIMRPRGWHVGQLAEFYPSERNLLGLNVNRGEKILLRLRYPGDRNQFLPFEQVVDTMLHELSHIVYGPHDAKFHALWDTLRKEHEDLTFKGYTGEGFLSDGKRLGGRRMPLHEVRRLTRAAAEKRAVLSSGSGRKLGGAPPRPGEDIRNVIVNAIERRNKTLQGCGNTNHSEREIQDISDSATRNGFKTQAEEDAANEAAIAQALWELVQEDEKAKHGSSYIPPSAANPAGTSGHIHGAQNGYNSSFLPNDESSRKANPPSPPPIPNATKPTPEPTPTEPADIWACNVCTLHNPSNFLSCDACGTSRPAAATQKSANQRGTRDPTVIDLTSNSPPKPSNAKTRRAGGSGGSAQPPAPVVPATWQCSFCGTNMERLWWTCSTCGRLKDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P810</accession>
    <name>A0AAE0P810_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_427036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P810"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF121">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3395038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="503" mass="54679" checksum="84F982A6A4DD0939" modified="2024-05-29" version="1">MASLKRVFGSVTLVYSGTSSSQPCTDPDCQARPKHHGTNREVNLVYSFPDWLVRGALSIFFSSNLNGSPELNIRLLYRIASDVTTISQSIFGYVYRRDVEGLKRLLAEKRGSVYDIRADTGKSPLYAALEGGDLAAVKVLLQAGADPWQSDGVASDGYAETPMTFALLLYIARHAIADDVCRLLPVFDHLQDEDVHLHLAIIGLLDLDIAEALQKPRYLSTINHRPQSMTGLSPLHLASMRGDLATVKLLLRAGASIDLKSSSQATPLHQACKFGHYQVARHLLSAGAQVNALKTNRQIPLYCASTLPPNPHNSGARIARLLLQHGADVNSESICGIRPLATAAAAGNAATALVLLEHGAHLDHRDWEGDTALFEGVFSRRHDVVRLLLAQGADAANVNDYGWCALHHLAVEGDVAMMTIFAERADGRLDTAARDCEGRTPLQLFNNRRDPTRELREAFDALLDCIEERRAMGMAGGISVGEGEAVDGLSDDEEYVDAQEFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P875</accession>
    <name>A0AAE0P875_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P875"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="162" mass="17840" checksum="E54D4D6923BE86FD" modified="2024-05-29" version="1">MLLRRGLLRLGTHPRLLDGRPVVILLELPADLLHRASSAPGRDLPVHLLFTTLRLQQSLGRPFAPQLLANLAKNILFRDNATLVRLPLVVMMVVVVVVFHISSSGIAIAGLLLDNFTVTWRSFSLGLSLGAHVGCDFPSGEHISYSSVLQNDVVKKQKVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P878</accession>
    <name>A0AAE0P878_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_492117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P878"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041914890" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="123" mass="13686" checksum="26E7192F7E53570E" modified="2024-05-29" version="1">MKLQILATVTLATLVQIASANFEIYMAVWHIWPVPPDCSQVLGSKNPNYLGDDDVSGNKIGTIYKGRAYRMYGLDGKVYGKCMLFPAHKYTCGNPITSGFTGTRKFRCLTEFTTDQIKAAWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8G5</accession>
    <name>A0AAE0P8G5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_408500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="912"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1737" mass="188141" checksum="BE0F921AC9865317" modified="2024-05-29" version="1">MVVEITPYQRRLVAVVPGAGGRLAGREKGGTISTLASTVAAATDTKYYIYSSKSGKSSGGNVHVLSPSPKNIDDFLSLLPDEGIALTSTPTVTSAVLDASDKWATWMTNWDASGELSVHYDDPKTLNFQWFEFSIKAPWKIVFSSKTGALNFAFGVDPVKGALVPVPGVADEGTPLYFGLDPVATTSDPKSSVADLFTWVGLDSLGQNLPIKGLSLIKTTLKRASASESRNALWFSPEQQLKATMRLQFELDSAKVLSDTLTSVLPGLEFQKFSIACKKVLVLGETSNGKEAIAAGDVEFEIDCSVKTVNTMELSLRVFPSSLELNFKMTSPNAFAGIVGWIVGLLPGDAGADTIEKILTNLFKDHFFLHRLTVSIDTSGSSPSLAGLSVDIEVAGKFGQGSNESQMPAFLISYNWAKGFGDLGSINGDFWTYFNSDKSRVLDPNYRAAIDIQPFTTNPATEIDLITLIPGQKIENVPANVPTKITAAGLYLSQEKFSFKTTLQSADNIAGDQASDVPQIDLGRIDLAASYTWGKASDFTLHLGITSILTPSTVSKHQDSAILSGTLDYSSGEKTWKLHASLEGLYASTLAEFFDKESVDHVIPLIDSLMVDHLTLDYQYTGTQKIPGNKSVGTYFNFDGLILCGGFGLKLTFNFEDKKGWKFTADLQAEDKDAKLGDILEDILGESLDIPPFLRDTTINGKNNEGGIHIVVERDKGDQDAAPAAFQFMASIQIGELALTFAQVHLTKWDPKKPSKRLIKFALVGLPDVDIPLVGNLTQPFDEMYLMWVQDGTELNKASPGLTREEVGVLNKTLEATGHPLVPKDKYAAPDIKDVLVSAGAHFAIVLKDQQGVRTCVLDYDFKKAQPKQQQKKQGLLTSGDDEDVEVEAEAEADEDEDVPDSDGQASSAPFKKKAGPLQISNVGLKYADKTLHLRFTATFELGPLAFSLIGFSLNVEITSLDISGIRMLAPSLEGLSASFEKPPLTIAGLIRHGEDKNGLPYYAGGIIVGWVPYQLQAAGFYGEAVPEGGKIPDDVFSSFFLFARLDGPLVTLEFAEISGVTGGFGYKSEVRVPTADQVVNFPFVKSTSLAGATESALTTLERLTSPAADGWFKPRNDTYWAAAGMKIDAFQMLSLDAVAVVQFGQSMKMGLFAVALADIPSSASPVKFAHVELGIAVVIDLDYGTLKAEAQLSPNSYILDPNCHLTGGFALYYWFDAPHADRSLTGDFVFTLGGYHQAFKVPPGYPNPPRLGISWSLGKTLSITGQSYFAITPKACMGGGRWHAAFHAGPIEAWFDVFADFLINYKPFHFLAEAGISVGVRFNLDIWFIHIHISVEVGADLTLWGPPVAGRVRVDIKVAKFSINFGSGSDEKPPASLLEFYQLVLQQSSKTDSQASKPQALAGRQPLAVTAAGEDSAEEEDASTPKKNEGHTFLAQSGLMNDTDKPDRTHNQDWTVRGGTFSFILGCKMAIAKAEQVDEHGVVIPDDPTNPKGNPVVDFEENTPYARPMKLSGDNSLESTVTICITQKDSDDPARAWPMEQFVKSVPTGLWAEYDPKYDPKKSGNNIDALLDTADGSVPLMMGVLLFAPPPIMSADTLQTFKILDADWQDLPADKYFPAIVGGDDDWVGEGPLYGAAQWNAVHAAWKTPDWDKPSPVTAADDSDEEEGSEEESDEEEEEEEEERDDEEGGDVQTSFVSTWASAFGWSSTLSSIAKIPSLLDKRFDELYVASPLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVG4</accession>
    <name>A0AAE0TVG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_494855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVG4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="172"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3380860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="447" mass="47694" checksum="2A1575BE91338F0A" modified="2024-05-29" version="1">MTYDPTTTDFDVVIVGAGLSGLKAAVDVHKSGLTCVALEAMDRVGGKTLSVDAAGPGIKGRGRIDLGAAWINDTSQTEMTTLAEQFGLELIRQRIAGNYLRQKSDGSVVSYALGFGDLIEHPKVLALHQMLIHLSEIWLGPDAKLLGSVTFKALAEANFPGEDAVSEAADFLAGAQFFSANLASLLPAGTVRLSSPVTKISQTSGVCITTTTNGTVFHSKKVILSVPTTLYHMITFEPPLPPPKQVLAQRTFLGHHAKTVLIFSHPWWRDGGLSGVMDSTSPNKNHCGPTAFTRDTSCEEDGQYSITCFIVGEHGRLWDALPKKERQKAGFGALQQSFWSAGKEPWVRGGPMPVMGMDVLDGEAGKALCEPFGDVHFVGAETASVWRGCMDGAVRSGIRGAEEVIGVFTVNSSAYAIGGRLAPSLVPIHNRARPLSLSEMLNVRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWA4</accession>
    <name>A0AAE0TWA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_215838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWA4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="115"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3381907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="616" mass="67175" checksum="AF6436A9D7AD7536" modified="2024-05-29" version="1">MTSRFDRPVTMHPSMDRPTTNYPARRERPITMDPRMERPIRPPRPPPRPPRPAHLGEEYEMFTYAERYNTPKSSTGDNRGWATSSNDPVLPAHGLDDEAVEPEHGNLAGFKLFAVTSMITVVVFLMMLDQSIISTAIPRITDEFHSLKDVGWYSSVFQLAGSIFQPLAGKIYTKFESKWAFLVFFGVFQIGSLICGAASNSTMLIVGRAIAGLGSSGLMNGSLTIVATSVALDRRPTITGMMMGVGQLGILLGPVVGGLLTSFSTWRWAFYINLPIGGAAAIALFFLYVPDIEKPKAMSVVRNMHREFDLFGFVLLAPATAMFLIALQCGGHEWTWDSSTIIALFSASLSTFIVWLGWNWWMAEHALVPFHMLKRRHIWSSALAGTGLLSTVYLASYFLPMFFQAIKGVTPVLSGVYVLASILSQLVFAAISGPLVERIGYVIPVMVISGVVISVSNGLISTFSPTTTTGQWIGYQILNGVGRGLGMQMPVLAMQTVSSQRDMAMSLSLMLFCQALGTALALSVGNTIFQECLRAELAIHTPSVDPLVILQAGATNFRGLVSDTDLAGVLEAYAFSIDKVFYLAVAMGVVMLIATVFIPCVYIGKKQQSQAEPNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZR4</accession>
    <name>A0AAE0TZR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_543826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZR4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="47969" checksum="9400DED6B9A51CAB" modified="2024-05-29" version="1">MSDYDDNESSSDASHWNSSDDKVWGFEDYDEPLYDFSDEDGEDFPTRFSHDEYENHGDGSQNNSETGNIIALEASSRKEYHDFVDDYSVSSYPTSRGQECRRRSYLDYHLDYPIYPGLGRLELWDTSYQQSKPAQSTHTDLVTDRKLHRQSGTSNNRNQGYEYYAGPNLRGISNPELMNFYGGIHGFMHSYGPATLIASDYEAAYGSLERRRPYDAYLECRSRISKMRRNLAAQHGAYHAAPVPGYHQQPPNMLSQEEPSYYSGQQPSNIFGGKPSNILGQAQYSHSRRQTQRLWNGFFATPYPTHPQDTLAAGNYHDWHHPRIHGHGEILDGYVKQTHSSTGHQSAAPINTSSYRLLSSKIRNQPPNSEASSVTSSMQDYSQSHVTDENHAAAATFSPGPYQRQYRSSSSSEPSKDYYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0E2</accession>
    <name>A0AAE0U0E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_433831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="421"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1327" mass="145480" checksum="A5A4228223A1C73A" modified="2024-05-29" version="1">MTEASPDTGKIEINDEGADPTTTPPTAPPVTPAGDGAQDGNAKDDAEAAVKPGSDQDSGEDGGEGEDEGEDEEDDDEEEEDEEDEDEDDDEPKLKYARLTPHLGPVYRNGDATSAFLVAADKMIIGTHNGNIHVIQLPVFQSLRVYHAHSASVTSVSISPYPPPLPTVKTEAAARAIAQSNNPQQPGTGTTETQVTPAAARKPRERPGVSNTSSNNIHIATSSMDGNVCVQNLIDIKDVTLRNFARPVQAIALSPEYKNDRTYISGGLSGQLILTVGAPTGRSTATTTGAAAQAAGWLGGMVGASSGKDQVLHSGEGTINTIKWSLSGKYVAWLNEHGIKIMRTKLHLDSTDADDAWKRIGHIDRPQSDDWETMASVWKGRAEWIDEQAVELDEMSREHQEVVASPAAEKLKQQQLRSNKKIERLLVGWGGTIWIIHVHPGSIGVGKNPGERSAGRAEIVKLLRMDCIISGISLYTQNLLLVLAFCLPEKEEEGEESAGKIAHFHKHSSSVTSTGSEPSGGIRRRQNNPPPELRLIDLTSQAEIDKDGLSVSRFERLSSSDYHLGVLPAQTVAAVASSRGALETLAGFGSEMLNVAFNPKALFSSGASVRSTNSSEGASGSKAATTASTMASTMRTGRAPAHPNLGKPGVKVFIHSPYDCILATRRDLSDHLAWLLERQKYQLAWELVDEHPEIMSSAEKPADHSPGTATPDRTQSSTDDFYDDTSSVIDGMRSFFSSAEKEKRKIGELWVQELIEAGDWTTAGQICGKVVSSPDRWEKWVWTFAGANKFDEIVNYIPTEPTHPPIRGTVYEVVLGHYLQTSKPRFRDLLDRWPTDLFSVATVTTALENQLNYRDVREDTVEDGEVGRDWRIVMESLAKLHEANGRTREALRCYIKLQDADSAMRLIKDGHLAEAITDNIPSFIGLRVPQDRIKFMTPGDIEKATSEAITLLVDEAQHGLVRPDVVVGQLQAKELHRYTFFYLRGLWHGEGIHQHQGESHARLVSDSKSLVDNFADLAVHLFADFDRALLMDFLKTSTAYAFERAAQECEHYDYIPELVYLYSKTGQMKRALTLIIDRLGDVSRAIAFAKEQDDPDLWEDLLEYSMDKPRFIRGLLEEVGTAINPITLVRRIPEGLEIEGLREGLKHIMKEHEIQYSISSGVARVLRSEVAASQNLLRNGQRKGVKFEVAVQGADHVDVEVKDVATLDAHLKPVQPEDGEANGDATPTPKPPRGAGKKWSPGHCAQCFESFFEWETETLVGFACGHVFHLAHLLEQLHPGEAVDEDLLVGVGEQRSHLVGAKVTHARLLRDRIMGGCPVCETKETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0V2</accession>
    <name>A0AAE0U0V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0V2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="52330" checksum="D33C53ACC7D368B8" modified="2024-05-29" version="1">MDRRTPRIAFPWLPAGPPNKRTLGEFHDLTLASEYKLGVAKREYGDLKEARQRFRSVFVKRANLLGKSHPDSLTAKREFVITSCALSQWENPDTKREDSRSLGRPSLFTQQSSSSRGTSADLDYRSTLGRKSTISSFLSDSDNWAAQGPVDETSAEDGQEMTLDDWTSVEQCSHNIAAEQESRIGTEHPETLDTLLSIFAVQLLVGKIREASQTMDTLLERLRRPRVQEQRLLHALQMEQKIAMICLDQNQVADGIGILSHIIHRGQQYMGDAATEPAHPELTALVNHCEEQIIAERENAESTVGRILEVYHSTAENETRQADANIYLANAVKLAIWALGSEHRKTQIAKAKSVQRYKKLVSEVEGLLRRRDLESTAEILSQGYMLLEAMFPDRDVEELRSNLEKVLDGEEQRVRTIMEAEQTKQEVEVDNGVAEGIVSNGVGDDVVSKVVETLLKFIEVENSEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U177</accession>
    <name>A0AAE0U177_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_140998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U177"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="461" mass="49945" checksum="229A7CF5B89ACED8" modified="2024-05-29" version="1">MIQPPARPKIMMSRIARLGLGFLSISRTTNGGILDCQRAVAEQGLDVEAGVILSLTYSARLERYPGLREVKLGLQFWTPIAGPYIATTLTQTSIRENKENGWSTVSDETSIRYGLRLPLRGPFFEVEHIREKHKPSPTAIRRRIVRYGTWIPRGSVDVEVEMTRTGDGKVDWTKTITTAYDGISTGKSVTRTMADPPTAAPVVADPMMELGEGSVGGPHHLAAESSTSAAAHTSPVAAPAPAFADDAPGQITQNDGAATWRVAFYVVVGILNRKTGAARESIAGTLTSQDKLFKAVRTASWGVWPLYKRLFSLKEVAGFGLYHCDVETGQHRSVTLDGRTRESLLELYTDYKADNGNMDDAWGEWTHQHLNGGSADPAKGDYTLELLLRWSAVKIVIYGLLPVVGSLVVGVAYMRVRVSEADDLGSDLAVIQTAWAISSYVVGAAGVNFALLAVITQLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1H9</accession>
    <name>A0AAE0U1H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein RAD57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_150830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="52417" checksum="5B583927B2818D1B" modified="2024-05-29" version="1">MTDLLRVLPHFPSGQFANLISVLEKHGLTTNDLLTLNAADIGKRTQLPLLDLKRLCAAVLNSLHADLGVAPSSSSSSRSRPAPASAALKNTAASLAAKWQTISTLDDALDAALGGGIPTGYVTEITGESGAGKTQFLLTLLLAVQLPPPHGLGRPALYISTEAPLSTRRLSQILTANPLLRSVNSADRPSLDNIISTATPDLESQDHILTFQVPVEIERRNIGLLVIDSVAANFRAEFDRSAGGPQLHHGSNMGARSTELVRLGMQLRDLGRKYNLAVVVANQVADRFGGGGGFKTPASSLRQVQPQHSSTQESPLAARSSKRPMSALPPAEPTSSLADMLPSRSSNTSMMPPPPRFPGEDDVVPAPPALLLDHQQRWFTGWGDDPAFDFGLKTPSLGLIWSTQISARIALSKRPSYDPIMSSSTGENSEEDDRDRLGMPKVRAWRRWMKVVFAPHAPASGPGPEDAVEFEVTMGGVRSIVKEKEEKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1Z6</accession>
    <name>A0AAE0U1Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_168432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3388043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28109" checksum="748200FB0B9E346D" modified="2024-05-29" version="1">MRDGKDGRTLVRKGRRDAGDHVPCVGRAVQDACLRKGAIVKAHTHREDPRHIWHPHRLPAILPPGRRPDRQAPRRDQTFQMSTKQPSMACWYMDVSHEVLSVTDGYRWILTYNLAISPELERPSAAFIHKETKDLRLALCRWLNRGDPAHLYYQLDHKYTEASLSRRALHGTALTWPECSAWRPSPPILSSKCFLPFWRKKTLARSSWMTTTTSITTAIRLAMTTAANPTRMKKWKTPAASGIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4I9</accession>
    <name>A0AAE0U4I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_108654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="124" mass="12901" checksum="FA2FCE5321E4C928" modified="2024-05-29" version="1">MYSAPYGYPNVAAGGPPFNGGAPPPQNNPHLQPGPSPNQPQQMMYNTQQFPMAAQGAHFPAGSNPAMMGGAGPAGMMQNTAMHHMAANGPSKLVWLLSSLAPPIPSTLCRHLLSSPTIHCCTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U512</accession>
    <name>A0AAE0U512_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U512"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="162" mass="18295" checksum="016B5A78A1AF9EED" modified="2024-05-29" version="1">MYSYSDRSRRISPRCGYASTKEILCLPLTSGVIRWIVFANLALIALGAFGGFCVALFQQFRPATEVSDNRPTERLLRRVEADIRVQNWAGLVGILVFDTVSVVSLEQTIARNQLEVEERQWTFGQVLAIFMLIRVTHVILAHFARLAGRERNPNELDLTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5C6</accession>
    <name>A0AAE0U5C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_500279</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="332"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3391210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="59329" checksum="74E67161C985B876" modified="2024-05-29" version="1">MVIPVNVRPFDDGGNATANGPSSRELFTVNSPNVTYTDSEIRSKYTYRTTSVNQTADGKYVATPRETVYDFKVDRKVPKVGAMLVGWGGNNGSTVTAGIIANRRGLTWETREGQRSANYYGSVMMGSTMKLGTDAKTLKDVNIPFHDVLPMVHPNDLVIGGWDMSSLNLAASMDRAAVLEPTLKALVRKEMAEMVPLPSIYYPDFIAANQKDRADNLISGSKACTEHVERIRMDICDFKAANSLDKVIVQWTANTERYAEIIPGVNDTAENLLKAIADGHEEISPSTVFAVACILEGAPFINGSPQNTFVPGAIQLSEQHGTFIGGDDFKSGQTKMKSALVDFLISAGIKPTSIASYNHLGNNDGKNLSSQKQFRSKEISKSNVVDDMVEANSVLYAPGEHPDHIVVIKYMPAVGDSKRALDEYYAEIFMGGHQTISIFNVCEDSLLASPLIIDLVLVTEMMTRIQWKASSAEGKEDFKSFHSVLSILSYMLKAPVTPAGIPVINALAKQRSCLTNIFRACVGLDPESDMTLEHRLADLPRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5I9</accession>
    <name>A0AAE0U5I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_447280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="316" mass="36023" checksum="2A58FEAC392C3EE0" modified="2024-05-29" version="1">MASATVAAKVQASTPRWTLILTRLTEGLAFSWQKATAIAWEVSSREQVEVILQFRATAAESDWQHHLRRYDLTPAFVPGRVERQGQNYKLTSTWQAFFWAALPSLTFAWGYFRTFETRNRTFGEMDVMFQNGVPARKSAKYVVDAEEVYSQADWARGNWHRAKSTGNVTTTSIDKTFKPQDYHHTANQIYSTTSAQPKPTMPELQGKRPHDPYIVPAVVVVEMGPHQQPVAHAPELPADPPVTALMELPNNSQQSTMVFELPSYSPQHRGDDVTVESLVVRQTKIRERRQRLLELEQLEREEEEIQRRLAGTKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6S4</accession>
    <name>A0AAE0U6S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3392710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="391" mass="45272" checksum="9FCB356A0C712231" modified="2024-05-29" version="1">MITRIWAWPRRRFTVFLFFTSCVIFLITAIHYRNISVKEAKHDSFYRKRIIEHMRPVPRGGKLAAKLKPADLMARGLQNTDLRRVPRLIHQSWMSTELPARFQRWSDSCRGMHPEWEWVLWTDEDNANLVKTYFPWLEETYRALPSEIYRVDLSRSLYMYAFGGLYADLDMECLHPVESILDAYGMAQSPQTSSENAPVAFFGRMGLHNSLWASIPNAWMLSTPGHPFFLLPIQWTQWRSVFTHDAFKWAPYFGTAESVTGPIALRNAILEYGKSYGPEVSGGAKRLANRLAAHPMGSMFMNQTARGEGEGHRVELLHHDVIYPLSWHSWDHVEEEHTTCKSTSDSLDVNLCKDMLEVEAKGSITITYWSHTHEAFDPSGHSNWSMDHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U744</accession>
    <name>A0AAE0U744_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_531204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U744"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="31692" checksum="F5D7F70A181EBDA8" modified="2024-05-29" version="1" fragment="single">AITVGLAGITGKFGRLLATHLLKNPQVTLRGYARDPSKVVPSISSSPSVRLFAGGALDDAAIKPFVSGCDVVICAYLGDNELMVDGQKQLVDACEAASVPRYIASDWSAYLETKEKVKGVHVMIGGFMETLFSPFFGALDSETNTFKYWGDGTEILESTTYGDAAQYTAKVAADPSAVGIQKFLGDRKSIKEVAASFEKVYGIKPALQRLGSQEDLKTHMDELRAKNPANIYSYMPLFYTYHMINGSTFVGPDVDNQKYPDIEPETWESFMRSRSPKELSTSMYALASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7N9</accession>
    <name>A0AAE0U7N9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal transduction histidine-protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_29906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1351"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3393847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1515" mass="164811" checksum="3161BFC8960EF32F" modified="2024-05-29" version="1">MTKDKAEPSTSPPPPLPPSPRCAPAQGAQSPAVPAPAASRRPPSPGSPGPLANSVCRRRRGLSNTDQSTVEKAEQPGGGQAPEAVRYGLTSPATDHDPLAVARPRTGIPESPAEATAGTGTGTPRVSPGALGKRSSEPEKRATRKHESPSKKPRRLAPGSLSLPSPPHTVGKTTPGEPPLTSPLFFSSSAKRMPARPPSFTASEVSASIMSGGQEPHDGVTTLRLPKGQISAASPSRSTGTPGSLSSAEFSGFSRSPDAWPQTSSAQLLHGIGAAELLEQDERPTFAIDLTDASNHSSGPLAIIFANASLRTRRVLLEQLQQTDTTDPDHDPEFAQFKAWVVSLARDKGGPDIGSPSQSYGGITWRCSTVRRRFRFVSGAANALSTNSPKMLSPMAEEAVAGSERPARSPSAGPKLALLKEQGDYFGVVEQGSLSPVSHGRARSEPRGKPEATAGTMFLPSSDLVLGASTLPQLHTTFDWTRIPLDDPALGTHHRFARSVDWASTPLGPVEVWPAELRIMSNMIMGSPHPAAMYWGQEFVAIYNEAYIALAGAKHPGLMGARYQDAWSEIWGEIQPVFDAAWYNGDATMKHDDGLFLSRHGFLEETFFNWAIIPLVGSDGSVVALYNPAFENTRRKVNERRMLTLREVGVKTSQARDVKGFWRQVQKGLEYNEYDVPFALIYSVADESDKSSMNSGSSSNPPQIVLEGTLGVPDGHPVAVSSIDLRRYSDEGFAPYMRESMAKTDCPIILSEEDGTLPSHLLEGLSWRGFGDPCRAIVVFPVHPTTAGDAVVGFIVLGVNPRRKYDEDYKLFVTLLDRQLATSMASVVLFEEEIKRGQRAARLAALDRQELSMQLHLRTQEAVESEYRFTRMAEFCPVGLFIADGLGHINYCNDMWWKIAGEKGTSTLDVWMQSIRDEDRPAVEKVWRSLVQERQAVTHEFRFKGSRQIIDGHSVDTWALMSAYPEKDEYGGLKSIFGCITDISQQKWAEDFQKQRRDEAVEMKRQQENFIDITSHEMRNPLSAILQCADEISSSLSKHKAGDALSEASGLNIMAMIDSCVEAANTISLCANHQKRIVDDILTLSKLDSKLLLVTPVDAQPASVVQNVLRMFEAELNSNEITGSFCIEQSYRDLAVDWVRLDPSRLRQVLINLMTNAIKFTQGRPTRSIVISLGASKGGAREGLSYIPPRHPEKGDITDEAGWARGEKISLHLAVTDTGPGLDDDEKKILFRRFSQASPRTHVQYGGSGLGLFICRILTELQGGQIGVQSEKGKGSTFAFYIKCRKSENSELGSSATAPTPRPSSIGHPSSLSAQPEALPHPTKPAPSTKKAVPAQLPPAPKEPNAARPLDILIVEDNLVNQRVLQRQLTLSGNNAIVANHGGEALEVLKRSRFWSENAAAQGNLAGFASMSLEVATSPAVADDEKQSKTNISVILMDLEMPVMDGMTCTKEIRRLENEGVITHHVPIIAVTAYARPEQIESAKAAGVDDVISKPFRIPELIPKIEELMKRHNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Q0</accession>
    <name>A0AAE0U7Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_458736</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="2122"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1611"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1692"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1904"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1649"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1701"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1748"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1759"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1778"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1816"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1832"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1952"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1995"/>
            <end position="2010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3393655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2469" mass="274646" checksum="9D1009103CBC6C5D" modified="2024-05-29" version="1">MAHANGHKHPLLSPANPPSPIGSRSRRDSLTSISVSSQADKDQLALTLDKIHTSASQSGVLTTFNDFAPPPGTLTVVESKGSTGDLVQQGLSGLYSRFKEAVGAVGKASAQEVDDTDNQEGTSKRSSDTANTAPKTVATSYPRAESGTTSSAVDSIVSSEVQKSGISSSGLATAESQTSLPQSSKASSMTTMSGPKSAPPSSQSLHKTANPSLAPGGGKGLVDMDATRGMASRTEESLGRSTGRRSISRPADNSPTPSPSGNASVDSVAISDRMIMPIRTRREDGLSIDGSTDMPRSPVKPSEVRASSSSRMPSGDVKKKPAVIDRISYSRVGNHSRSSSMEPGTAEPSPISTSAHSSVFHDSFMHNERPQRLQSGALKIPGTTTIEGAPEMVNARLEMMRKQVLSKEFWMADETCKECFLCGTPFSAFRRKHHCRTCGCIFDSKCTSNISGQRFGVQGSLRVCKTCLNVINRRYDSGSDDSADESYLPAIFRPNQSKPAQPVLARPRADDEVSISERTEHADDTRSATTPMMAIPATRRVGDNNRHSAVLEIDMPQLLSRPSSSRSLKSLAGNRPQSSGHRRHHSKHNFLTRFKASTEDRAPFRKSVNDELGKKSKLNAFHDDNIIDPELAAFMSDESSGDEQMGIFATMNSNDIQPSSLDPDRSSFGPYLGTGRKHRFRYGEKSVSGLSFTSRGQDEVGGLQNLSTHPRPPRRRNLSTASASVHHLRSPRPKSGVFNKGPSGSADALSLFESAGTAESSALKRRDSIRDGKSPEEGLNPASLLHVKKLFRQLLEDASIPNPAAWEKALIPILDRCADDVDPNIRNGDDMDIRHWVKLKKIPGGKPIDTAYVHGVVFTKNLALKSMPRKIRNPRIVIITFPIEYQRHPQQHFMSLQPVIEQEKEYLRMVVNRILNLEPHVLLVEKSVAGVALQYLSEANVAVASNVKPSVIEAVSRIANMPIISSMDMLSLGARVGTSASFEVKTYVNNELKGKKKSYIFVAGCPKDRGCTIALRGAPTQVLARMKKITEFMVYVVYNLKLESCLMRDEFVQIPLDVECSVPSTSRQHTDYSLLVSLANPDILVTSQSTESEKVTQSTDSGATDTEQPGADQPAQTLQGAPEQTRRLISLHESHSHISHDNQVPEDVPMPTYYSDMVAKYETRILSASPFVKFTQPYLLMKAREQERRLVYLKRLRDQDIVEEHGENEKAKQQRFQLIKPEMVHEIGQKAPRQIMEVLHAVHDAEYDKALHNYQTQTKQWENYIQGSLDLFDPYSHQNIVVLYSVTCTTTKIPCAEPELLAIEFYNEHPDPTGNMEPDCTVGQYIEDICEAADSTCHSNGCDRKLFEHHRTYVHDNARITVIVENTPAWPENFPDKPQKESDKEGTGICMWNYCKFCKKHFGLMPMSVSTWKYSFGKYLELSFWSRGLRLNPQTECPHDHQRDHVRFFYYLYRDIAVRVHYDPIDLYEIIVPRPRITWKVDNDLKLKNELFTKAEERWNRFMNSVKARLKSIRIDSVLPEKADACKSEVEKLMKKAQEDQPQLIRSLQEAYMDSKYYEIIPLNAVIRGMLVKVSDWDAAFAKFEADFLSDKDVRQLTIIQLRKIFTDNESKESLPATDGTASIGSESEDKATPVTTQTSMSEADEKPSQSSEQVSESDPNQQLQPPGLAILEPTPELRETAENQAEELRERVEPLDLATPNPSSPTLTRSVLIPDTEPEVAKVPSEESIVPAPTPLPTPSIPRQADSMASTLPNEMSLQEKVEQLRREQRVNSNDISGSPSGGADPASDGSRPVSDKASRRTGLTVSPPIARAVTTPTGTLPRTQSSIGKLLKEQKGQDSGELHRGSADGSLKGEKKFTDRLGFGALKNRGKAGPSGIPRYVHKRESKVSTLARHFEQLSREFEKERMKDRKQRAANMQSTRAFLPRASTKAIVEVYKDVDQAVREPGPSDDDHLLDNESSEKKPADATNSADATTDESQNKPSESGLEVNGEPPSQASQAGGETTNNTEGDENRHESQANSDDEGGGSDADQSMLTLDDILPDVKDIAASMEPSEELPEELPKHQKKSLMRMLTNFWAERSASGWPQLDYPINATDHIFIDSNVVVREDEPSSLVAFALSSEDYMAKLDKIREQWKISNHRDTDDSGDGLEMKGRHRHSDFGDTAVNEEGLEKSLLRSTGTHLKYQFTEGSAKMMCKIFYAEQFDALRRKCGVADRIIESLSRCLKWDSKGGKTKSVFLKTLDDRLVMKSLSPIETSAFLDFAPAYFNIMAEALFHDLPSVIAKMLGFFQVIIKNPLTNTEIKLDLLVMENLFYDRSPSRTFDLKGSMRNRRIQSTGEQNEVLLDENMVEYIYESPLFAREHSKRLLRASVWNDTLFLQRQTVMDYSLMIAVDEVKKELVVGIIDCIRTYTWDKRLESWIKDRGFAGGGRNKPTVTSPKEYKSRFREAMARYFFLGPIIRWPDQVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Q8</accession>
    <name>A0AAE0U7Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_532103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7Q8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="282" mass="32440" checksum="411ADF4D70481DAB" modified="2024-05-29" version="1">MSTSAPRRGRQAADEPGFTSLVDNPPELVRSGRKHGPGLIILAIIPVTAFILGTWQVQRLKWKTELLAKCEDRIVREPLPLPPRVDPDAIVDFDYRRVWTEGHFRHDQEMLIGPRMREGEQGYMVVTPLEREGGEGSTVLVNRGWISKKVMDQSKRPDSLPTGKVRVSGLLREPWKKNMFTPDNKPERGEFYFPDVRQMAALTGSQPVWIEQTMDPDYFQVMDFETRGIPIGRPAEVNIRNNHAQYIFTWYGLSIATSIMFWLVVKKPPTDIARRVRMNKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U801</accession>
    <name>A0AAE0U801_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tom37 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_516997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U801"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="415" mass="44393" checksum="FA056B00CACB158A" modified="2024-05-29" version="1">MVLELHVWGPAFGLPSIDAECLAAIAYLARTTSRSEYRLVQTSPSAVPTHHLPALHKPSANTWISGFSPIISHLRSFPSPSFHDDSPPHHGDSTAYSAFLTAHAAPLIALSLYVSSANYAATTRPAYSAILPFPLPWTEPPAIRASMSLRAAHLGLSSLDTDAAEDASIAEEKAAAAAGWVHIPASLSAQLKSKSVKDALTPEQAARIKLDGLAREVLDVLAEADWDRMVLSARCLAYGYLALMAVPDVPRPWLREVLLQGGYPSLCELVGRFRGPEALAAEKLPWEESAAHSGQSSLVAGLNVGARFAQGLIYDIPGIGEEWRRWWARRRKRSVRRPEDTAGLTQKRRDMSASGADTLLVAGVGMAAVLAVNAGFFLYRSGVPSFGAPVHSWQMVRAGLSSFGAAGAMFSGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8B3</accession>
    <name>A0AAE0U8B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cylicin I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_555444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47018" checksum="EC151160280A6451" modified="2024-05-29" version="1">MASSSETPSAATATPAAAQSYSTDPALYIYTSLTSGSSQIFTATSRLETILRANRVPFKAIDIATDEKARMLWGRRAGKDAEGRVRKLPGLVQEGMVLGDLVEIEDWNEYGELKQHVTIYYDEFTQPSIHQKPPTITLAPRKPAVVAASALPNAAAASVAASASAAAAAAAAVPAPPPMPATKPKQEATAEVPPKKSSTDLSGKTVTLPIRSVAEQAAQKAKELRTQSLRERVYGKGGSAATSQTATAKEGESKDKKDDEAAAKVVKEEEEEEEEEEEESSDEEEEEGGSSPEEDNSDEEPTAAAAAAKPKSTSTIPVGLQSPTTGGWKDSTTFHTLQSPTSTSWQPTDVEAPVTSYLGSVVAPASAEEIAAIERAETIPEEEEEDDDDEEEEEEDSDDDDEEEEEEEEEEEEEEEEEEEEEEDKNVKPKEKEKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYN1</accession>
    <name>A0AAE0JYN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYN1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042035593" evidence="1">
        <location>
            <begin position="16"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="447" mass="47723" checksum="C9AA0BF4E52B16B7" modified="2024-05-29" version="1">MLAVFTLIVAAVVAAAPTLAAKEVFAHVILGNTNALTVTDWEADMKTAKAASIDAFVLNVAQGDQNNDVSLSNAFTAAKNAQFKLFFSFDYAASPNGAFGKAGVKTLMDKFGGDDAYFKVKEQGNKPLVSTFEGPNNADDWTELKASTNSFFVPDWSSLGPVKAAAVAGGVVDGLFSFDAWPVGPTNKTTTADKNYQTALSGKAYMMPVSPWFFTNLPTTLSKNWMWHSDGLWDTRWDQVMEVRPDFVEILTWNDYGESHYIKPITKKDEYDGLLKTFGAPFDYVTNNPHEGWLKFLPFYIAQYKAGGKAPAVTKELAALYYRTAPALACPNGGTTGNNPQFGQTAVPPEAMVQDSISFAALLTSDADVKVTVTIGGTQIPASFSKLPAAGAGTTGVYRGAVPMGTNTGAVSLTVTRGGTTVAEAKGGPELSTKCQNNVQNWNVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1U3</accession>
    <name>A0AAE0K1U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_68765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1U3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="522"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="821"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="253"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="674"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3368087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1197" mass="137483" checksum="4DCE15D19EA82AC8" modified="2024-05-29" version="1">MHIKQIIIQGFKSYKEQTVIEPFSPGTNVIVGRNGSGKSNFFAAIRFVLSDAYTNMSREERQALLHEGSGSAVMSAYVEIIFDNTDKRFSEPGDEVVIRRTIGLKKDEYSVDKKVQSRADVLKILETAGFAKENPFYIVPQGRVAAITNMKETERLNLLKEIAGTNTYDDRRIQSRKIMAETNSKREKIDELLEYISERLSELEEEKDELRDFQEKDRERRCLEYAHWHRLQETNQATLDQIEEHRQGGAGASTKDRAQLQRTEKEIAAMEQKLHELKRNLELLANERHQLDEDHRENLRARAKAELKTKNLDENRHVREQEQQKQAAELREVRRKIEEAEAELTKISPGYEKLKAEEAEVKTQRDQASAGRNRLLTKQTHTTQFKTKQERDAHLKQEINDLTTQFGSQKANEMDAREQVESVEASIEQLKKDIQAIREKIDGYGGNQSTLAKQLAKAEETRDQLKEERRRLQREQDRLVSLKNNTQKERDDAESDLSRTMDSATARGLAAIRRLKRERDIPGAYGTLAELMTVPLEDYRLPVEQVAGNSLFHYVVDNERTGTMLSDHLYKNYGGRLTFMPLEQLRARQVKMPRASDAQPLISKIEYDPKFDKAFQQVFGRTIVCPNLAISSQYARTHGLDAITPEGDTTNKRGAMTGGWVDSRRSRLVAVRKVNDLRDLFDQQLEDLNEIEKKIDVTEQKVTSAVGEVLKLEQQMRQFESGFEPLKAEQQSKNAQLQRQQEHLEKARRRLVEVQKNLQEFDEQLTDCRAELASEFKKALSANEERQLEAFTAEEHKLQRELKVVSLKRVTLEGTKTRLETELRDLRPHEDQLRSQGFQDSGAGGSGSFKDAQKELKKAQKAAAEVERQLAENEKEVDGVREEVARLEAQKAQKEQDQQELQKRIDQYQKKMEKNIQTKARLTSQAAEYAKNIRDLGILPEQAFGKYERMKSEQIETRLRNVNEALKKYKHINKKAFDQYNSFTTQREQLLKRRKELDSSQSAIEELIEHLDQAKDEAIERTFKQVSKEFSTIFEQLVPAGHGRLVIQRKGDRGKNRNAEESDEEPATGVENYTGVGISVSFNSKVMDEQQKIQQLSGGQKSLCALCLIFSLQAAESSPFVIFDEVDANLDAQYRTAVASLLESISQTQKTQFICTTFRPEIVLVADKCYGVTFHNKNSTIDCVPTKEALNFVEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2D1</accession>
    <name>A0AAE0K2D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2D1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="431" mass="46566" checksum="3BB0BE1EFDF8FA71" modified="2024-05-29" version="1">MNAVTLWDGFGLPPPTATAFVQIRHFNNIFILLSILCLFEVIGFIEFINSAKLLEILELLELLELPEFLRFSLLQSCCVSNMQLKWRLYRQSFGRLLSMQQQSTVLGLRRCRDIVDQLFCRLGYHRFRRLQENMVSERLPDASCKCYECFDTTLRRLKIPISTCDQADSLGRTSVQVDFAPVSILTPTGPITQATGSIPPPAWTGSEGDMVYYAAFVGCHANKPHCCPWSVSGASIGPVASATITQRANVVAAEAGLFPVPGSSGQAAVASHTPCFSPFSATSTPPPITARLLRNPTESSLRTSAVVNLGWAMSYRVATVQPPPPSGLSTGAIIGIAVGAGLVGLAATGVAGFFSIRRRKKIQVRLVENRPDALPGVAYEPGYHAPPMASPPPPSVSAYAGTPSTANPVCDARVERDEPIRAFTSQCVKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2E9</accession>
    <name>A0AAE0K2E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-ribulosamine 3-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_529150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2E9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40568" checksum="3B17EEF6B78ECA0D" modified="2024-05-29" version="1">MSVIIGLEEPNSPKRIAFQRLFYYDETFGESGNVLTQLQEADHRPSVQSCSDHNLRFFLVALQTTEAITFDLNASEIDVDRHRGQQAPTEPVPKTQLGEPFELDQAAIDGTTSGHSVAHGRVWQGQRPISTLDSSPWSCRRDAMYGMSLWGHTAKIMVTGSNGEQEYCSLKSVAGTGTPEAQTMIHGDYDANPKTGFLLTQFRVIGAQSPCNPEAFAARLAALHRDSRSPTGMSGFHVTICHGTIPQAPGGWHLSWEAVYRRMLDNMVAVDQASHGRWPRPTLGPCLVHGELWDEITAEDGLTSEPFVFDAGSFYAHNEYEIGNWRAREASIERAEYVQAYKRHFLLTEPVDEWGRSDPAVFSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2S4</accession>
    <name>A0AAE0K2S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_441628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="518" mass="58395" checksum="808A99E88A97B944" modified="2024-05-29" version="1">MGSIWAAATNIVDTLGNLNLKANATIASTTIVAVLIWRIALTIRQYFLLRHIPGPPVAAFTKLWLVIKARTGRTHLDYFEACQKYGSYVRISPNDVTTDDPHLIKRAWAVRSEYTKADWYSSMRFHPDRDNVASTLDENKHNELRAKLAAGYAGREVDGFETRIDNQILSLIRLLETKYIPHRKPFDFARKAQYLALDVIADVAFSEPFGFLETDSDRFDYIATLEQNFPVAFALTVLPWAVTLMQSRLFKAIRPSEKDPMGLGRLMGITKRVSFERYGPDRKIRRDMLGSFVKHGLTAEEAESETMLQVIAGSDTTAGTLRAVMLYTLTQGSRVVDRLRAEIATHCTARSPSDVISDAEACEMPYLQAIIKEALRLHHPTSGALVPRVVGSKGDTYKGMYFPPGTRIGACFVGFMRRKDIWGEDTDQFRPERWLEATPEQLREMEGAVDLGFGSGRWSCLGRGMAQMELNKAVAELFRRFDFAILNPEKPWKSFNAGMFMTSEFWLTAYPRGEGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5B0</accession>
    <name>A0AAE0K5B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5B0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="216"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="591" mass="67001" checksum="B81FBAE99A888D88" modified="2024-05-29" version="1">MSGFEVAGVVLGAFPIAITALDKYREVATRLGLFFKIHLEYKKWRDDLEFYQLVLTRHLRQLLLPLIADNDKIEELLSAPGSKSWKDDSMASLLEKRLRDSYQLYFEYIKGIDRVMKDVNRELAVDLDSVQQRLNSPKASSSTAKPKSITSKEKLVFQLYRLKFSNNDAVRKRLFGELQDYNDKLEKLLDSSDKDTRLVQQRTAVGQLASIDAAICNFWVQARNLFNALAAAWSCRCQHHGARLLLQHRTSKKPDFQVMFTAFTSSRWEIHKTRISQGDDMVAATMNENITLLENISLSVSHPGHRQNRPVKSAFRNKHSNNTASATCVELLKAPPSVTLTSVQTTAQISLSQQISNLCASLRLPEGSCCGYLTEDDCRYYVYTISRQSADQLPSVSLDQILRGEVYPPPTRTQRYALSLIMASSFVQLLDSPWLPATSFKKTEVHFLSDAKDANLFLLDQPHINRDFQLDGGSPSEQVFNNAPFTDALDHLGIMLLELCFGRILEDQACRKRWPAGGNGKEKAVFDIMAARDWQCQVNEEAGPDYAEAVGWCLGGNRSTPSERWRQEMLRKVIQPLQRCRDYLTSGELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5D6</accession>
    <name>A0AAE0K5D6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_316094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5D6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="10338" checksum="0CCD00C6457500C7" modified="2024-05-29" version="1">MAQWVSEAAAISAMALMCSEIWAPLVMGGAAFHIGSCLSKMSDEHGQLSILACCSLFASVTGCHKGVVRKGNKLRMPKATSMAALSMAGYKGKMKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5Y3</accession>
    <name>A0AAE0K5Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_487403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="38867" checksum="55D269ECED8D50B0" modified="2024-05-29" version="1">MSSPFCLAVLLSQENLDLAKTCIGGEGTTILTWLLRKMMLNSAARFATDSDSDSCESLEVLLTGAMDEDYMGKPLKPYSEPLAQCVRTCLEYGADVHIPDQYNKTAVDYFTELLHPDGGDGGGECGTSPQYCIRILKFFSRYSVLVSHDHHKRIVIEGQKRFKMSPEMNLEVGYWSVTRPKETFGACFEVIWKEEGENSVSCHGGLLDKMCYNRYCDKDEYGIILPQYGHECWEEKYFDWLRDGGDMTDTAMVKKVLRLLTTTVTTTRKTETLRKAMRTASHRLRLTSWGMMGRAEWMQKLTVSMARHRSMSPSRRTMPPGLRKRAVNRRTKAGRKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K610</accession>
    <name>A0AAE0K610_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_486729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K610"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="113"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3370307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="512" mass="55946" checksum="449C27A147EE1046" modified="2024-05-29" version="1">MANIAPSVLRQASRLAAKSVISAAPRRAAPGALSRVATASAQRQTAQASRLYVTETKRDSAQVQAEAAIRLDKKDIEKSDLSLNAQDGSASHVSPMADILKQATVMDEGQRPIYLDMQATTPVDPRVLDAMMPFFTGEYGNPHSRTHAYGWESEKAVEQAREHIANLIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHIITSQTEHKCVLDSCRHLQDEGFEVTYLPVQHNGLIDLEKLEAAIRPDTALVSIMTVNNEIGVIQPMEEIGKLCRSKKIFFHTDAAQAVGKIPLDVNAMNIDLMSISSHKIYGPKGIGACYVRRRPRVRLDPIISGGGQERGLRSGTLAPPLVVGFGEACRIAKGELPYDSKRIKYLSDRLLKGLLSMEHTSQNGDPNHFYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGNSDESAHSSIRFGIGRFTTEEEIDYVLKAVTARVGFLRELSPLWELVQEGIDLNTIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K634</accession>
    <name>A0AAE0K634_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_402289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K634"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="46682" checksum="28FD8127A24F7040" modified="2024-05-29" version="1">MALPSSSSTTSPVPSANTSFLQSPAAIPPRTSSNFSASAVPSPATQPPPSSKAALKPVPEGDWIAGNQPAPPGHTRHRSRKTSITTVGATSFLTTTMAQAPQPPDPNRYATEDFSFNAKRTWSEEKEKVLMGPFDYLSEHPGKDFRSMLVNAFNAWLEVPQESLEVITKVVGMLHSASLLVDDVEDNSLLRRGFPVAHTIYGIPQTINSSNYVYFCALQELQKLRNQKTITVFTEELLNLHRGQGMDLYWRDTLTCPTEDDYLEMVGNKTGGLFRLGIKLMQAESRSLIDCVPLVNIIGLIFQILDDYQNLWSKEYTANKGMCEDLTEGKFSFPVIHSIRSNPHNQRLLNILRQKTSNEEVKRYAVAYMESTGSFEYTRKVIKVLIERARKLTDAIDDGRGKSKGVHKIIDRMIIEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6X6</accession>
    <name>A0AAE0K6X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_487297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="10"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="374" mass="40186" checksum="181B3243C009A0D0" modified="2024-05-29" version="1">MAHSIPREMKSIQVAEYNKPYKINPHTPVPLDLGPHDLLVKVAVASHCHTDRMVRTGVFSTALPCIGSHEGSGTVTVVGSAAEGSFKTGDRVMCGIPLHPCGKCADCHPDSPEKQRQYCSSESHVGVLTDGCFAEYVRVDARFTTPVPDNVSLVIAAPLACAGRTVWRAVEQAGLKEGQWLAIVGSGGGLGHLGVQFAKAKGLRVIGVDARDAGLELTKESGADVVIDARKGKDEVVKEVRAATGEKKGSDWGADATITLADVDSAAALACAITRMHGDMIQVAQPDQVKIPFQELVFRDIRVRGTVLCSPDESRDMMKFIAEHGIKLKTNLFHGLDKIYDLVAKVEEGNIQGKAIMIVDEEQIQREKELGVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K858</accession>
    <name>A0AAE0K858_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_281985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K858"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="24277" checksum="DBB329F986A725B5" modified="2024-05-29" version="1">MYMYPAVVAAQRQGSSPSRGAAARLHISTSAPVTSRSSEVARLMHQTPKRRSAPWRQVPIHLVFPGMFSYNGRTPTKPYAATNTLPGGEAQKPRATVGQPKESEGQRQSPDRSEMRVGAWLFLLSPPCYRVIHANFSSRNRNHNGASTSKTGSREARQIPHSGYGRSRCHASQTTSLLPPSQCKITLPRWIRAAPSLTTFEPDSSIMAQYQMRQYSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9D0</accession>
    <name>A0AAE0K9D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_483321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9D0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="582"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3371932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="718" mass="78325" checksum="4843751E85EA41D0" modified="2024-05-29" version="1">MAFQARLVPLRLPVGHLTRRPGAVPAHGHAGSCHLRTRIDGLYSVRGIITTTAGLSTSVGPTEPPLLQHTIPEHFASIVSRYGDRPAVSSRSPTPAFIRHQPNPAQKIPRSQEPGARETSMTYEDLDLVSNSLAHSLRSLGVEKGDRVVVGLGNCPEFAALTYAVFKLGAILVPLNPAFNEKQVKAALRHLEAKILIIGAVTDLAYKPCYGRSNEPLLRAMIPDLDSPSGMANAPDIPTLETVVLVDNSASHPLVVFPSSCRSLTPFSSLLETGALSPNPSSSSCRPVTPSSPLSPAETINIQFTSGTTASPKAAMLSHTNILNNGYLIAKRMGLQPSDLIVCPPPLFHCFGCVLGYMATATTGAGIAFPSPAFDPLATLTMAADHRATGLYGVSTMFVSMLDVLENRRHYQENTTLPSEDKLGMVNQHLLKGIAAGSSIPQSLMNKIYNSLGLRNLVICYGMTETSPVSCMTSPTDPEEKRTGSIGRVMPHTKVKVVSPTDRTKTLFRGHRGELATAGYLVMQGYWGDEERTREDRIPDEQGEVWMYSGDEARMDEDGYVEITGRIKDLIIRGGENIHPLEIENCLFQHPAITEASVVGVPDDKYGESVCAFIIGREGIELKPDEDYGPLPCTTRSDIAQAVEQNRLLTKQEVRAWVQKHLSSHLVPKHIWWTTEFPKTPSGKIQKFMLRELAVRLLAKEKEERDRRGLEQVDDTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9I8</accession>
    <name>A0AAE0K9I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_283598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9I8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="162"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3371945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="48183" checksum="67CDF66290002A04" modified="2024-05-29" version="1">MMASSVPIQRMQGPLRRSLARAAQISSSSRSYATIPTSSPSSESQSTTESSSTPSASSSSKPVTRPTYFKDSTVAPFSEFLPSAAAPLAPSEAYTLRTVEVGPAGRKRTITRLPEWLKTPIPSAGTNPNYAKIKADLRGLNLHTVCEEARCPNIGECWGGSNKASATATIMLMGDTCTRGCRFCSVKTNRNPAPLDPHEPENTAEALARWGLGYVVLTSVDRDDLADGGANHFAETIRRIKHKKPTLLVEALTGDFMGDLDQVRIVAESGLDVYAHNVETTEGLTPYVRDRRATFRQSLKVLEHVKAVKGKDNIITKTSIMLGLGETDEELWETLRELRKVDVDVVTFGQYMRPTKRHLKVEKYVTPEQFELWRQRALDMGFLFCASGPLVRSSYKAGEAFIENVLKKRAGQQKSSLSSESALGQAAMAAEETMSRDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9V3</accession>
    <name>A0AAE0K9V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_514079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9V3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041971104" description="Glucanase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="429" mass="46661" checksum="86632B9B26493209" modified="2024-05-29" version="1">MVRQLALSGLVFASALLGFASAQKPGPTPETHPKVTTYRCTKKDGCKEHTNYVVLDSLAHPVHQVGNSLNCGDWGNKPNATVCPDAASCAENCIMDGISDYSKFGVTTSGSSLRLQQVLNGQTVSPRVYLLDETEKKYEMLQLTGNEFTFDVDATKLPCGMNSALYLSEMEATGAQSKLNPGGAYYGTGYCDAQCFTTPFINGVGNIEGKGSCCNEMDIWEANSRSNHIAPHTCNKPGLYQCSGAECDDDGVCDKDGCAWNPRRVGVNDYYGNSNQFKVDTTKPFSIITQFPADKDGKLTQIHRIYVQDDKLIQSYTVDRPGLPKVSALDDEFCKATGAKKYLELGGTGGMGDALSRGMVLAMSIWWDEGGFMKWLDSGEAGPCNATEGNPKVITQIEPNPEVTYSKMRWGEIGSTYQAKCKKRLTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDK8</accession>
    <name>A0AAE0KDK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_548807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDK8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="19318" checksum="E7B7B7CDD7BF7B7B" modified="2024-05-29" version="1">MLYTTLPATEVDSILTLDLRDSNNKDKRLRSKTIKSLSCPLTQGNATLPLPLLLHRSGQFVPPSLVRGEDSNNNNNNNNNNYNNYNNNHWPPLYHNGYQDDTILGCNMSCQAMLRVANIKIAWVDSFPLHLEFDELTATLKPFRFPSLRAMLAMPRNSQSTIFDQQVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE43</accession>
    <name>A0AAE0KE43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L30, ferredoxin-like fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_257617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE43"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="248" mass="28659" checksum="23D54D0FA7F07ACA" modified="2024-05-29" version="1">MSSSVPTINDVLVPETLLKKRKSQEKARAERTAEQDKKKIANKEKRGVIFKRAEKYVKEYREGEREKIRLARVAKQDGSFYIPAEHKLIFLVRIKGINKIAPKPRKILQLLRLLQINNGVFVRVTKATTEMIKVVEPWVAYGYPNLKSVKELIYKRGYGKVNKQRIALTDNSIIEENLGKYGIICMEDLIHEIITVGPNFKQASNFLWPFKLSNPTGGFRPRKFKHFIEGGDLGNREEHINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEK6</accession>
    <name>A0AAE0KEK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_482481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000004">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3375288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="578" mass="62428" checksum="DA4B116029AFEDA3" modified="2024-05-29" version="1">MSGSAWLNISSPTAAMMRSAGPRALRTAGRQRLTPGWLMVARPSLSAVSAVSMVSRLSSNTHNHNHNQTRSLSTTATCRQNKLPEYDFDWTVDEPERQWSTPLAKQLAQAIQATGPVPLASYMRMCLTSDLGGYYSGALEEGRDQFGLKGDFVTSPEISQVFGELMGVWFVTEWIAQGRPSQGVELIEVGPGRGTLMDDMLRTIQSFPAMARSVDAIYMVEASPELRVAQKKLLCEEDAPMTESKVGYHSICKYTSLPIVWTETIKSIPVSPEKMPLIVAHEFFDALPIHAFQCVHVPATQSATPSAADQSSPSSRTSQPTLQWREMLVSPTPPDSTHVSLGTPRSQSHDTPPPDFQLTLAKAPTRHSLYLPESSARYRAIKKQTGPGALLEICPDAALYAADFAARIGGSAQHPKAKPSGAALILDYGPGDGTVPTNSLRGIRRHRRVSPFAEPGLTDLSADVDFAAIAEVAMRASEGIEVHGPVDQGTFLQVMGIRERAEMLIKVAAAAAAKGQREQGDEQAAAVVKDPAEVVHKAWKRLVDQGPGGMGKVYKVMSILPENEGKRRPVGFGGDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEL9</accession>
    <name>A0AAE0KEL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_562785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEL9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="547" mass="62275" checksum="C04F612827BF5F18" modified="2024-05-29" version="1">MEPREHSKRYSRQTWRNKARLWQHPSNLREHESGEALGYISDLQKNYHFVDAERCRMVVIVGQEMQIYLDYPFAPEPSRITDILHGRYSDHTDDYTPIFVSVDAVSDGGPFAITASVLDSLLSNLKIPWYYAEMMAKTKTSAGIGNSFTPCSDAYFRARDLLNSGSNFSASPDMFYYTIHFRQAHPDRGQRCTRHLAVYAHNKHPSTQPVWFVTSTGILNLSGVFKEWVAAEKGDTSTASFGQRDVRDQFTALHVFLAEVSCMNWDQDINEFDEMAFDLLDIINGSRDNGRKAADSETVRESCLEAEFLLDRSGQISRQIAHNSAIIQWLLDIHTDKRNEDLFLSPGAANQFERRMKLALEEYRGLGESIAGVAKVLRRRTDVVASLIARSQAEKMEWAVLQVLKLSFIMRNFVQTVGLVLTFFLPGIFISTLFSTEFFRFTYPSSDYEGTSSYVVVAGSFYIWVASALPLTFVILLVQMLWYRSASGISSKWTSLIPPRATWMTPWAVRFKPSFRVPPPQKQRCYPGGRMKKLNSAEVPSPEQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEN8</accession>
    <name>A0AAE0KEN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_400781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEN8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="951"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3374807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1198" mass="129334" checksum="F14054AA0600C486" modified="2024-05-29" version="1">MNASSDADSQPDAVAAMSNSSTSAAGTAGGAPPVAGDEVASTITVNTTTKTPANFPPPKTDKPRPHVCATCSRSFARLEHLKRHERSHTKEKPFECPECTRCFARRDLLLRHQQKLHQTGTPSSRPRNRRESASGATPGSRVRKNSVAGPSVGAGPGPASAPAASMRPRANTISHIDGAAMQMLAAANAHAVRGMPPIHSRHPSLVGLPMHNHLDHAYGMASAMLHRGSSHGLPKLETHGINGMDFSGGMRTAPPIGFGNGDFDFEGLLFGAPTGSTINPNALHYVDSPPSMALDPMSPFPHGLDLSGGQHMDDSFDWMNGFEHQLSFNTGHNENAIDGSSPSAISTTSQSGISDVMVDGSNHNVGAAGSTSMWTPSIMGPPQMSNPFSLDMNGSVFPDLLSGAPLSPQPQPSKSVGDAYFSTPPPSMSSLSPSVISGLNSQNLNQALNFGAGPETPSSMNGSNHGTLPVSTITDSTRNAILGALSTSQASQFGARRYSFATPTSPLTAQPSTNAQSSDHPSNLPSTHDLQRFVGAYLRYFQPHLPFVHIPTLSFEIPPQSANGRSSGIGGSGCLLLSMAAIGALYEMEHQASMELFGLAKKMIQLYLDERRKANVRKADFRRAPMSDQNSQQQENLVETPVWLVQAMLLNVVYGHNCGDKRSGEIASTHAAALVSLAHGAELLRPARVEPSMKDIEMMDADGSWNGAPRKEVEEQAEWLRWKAMEERKRTLYAVFILSSMLVSAYNHTPALTNSEIILDLPCDEDFFSADSSHAFLSKGGVAAANHNRMTFHDALGELLRTNETQQKLALNSGHHLFGSAVNVNDLPKSKLKPSTFGCLILINALHNYIWETRQRHHNKVWTNEETEKMHRHIEPALRAWHAAWANNPHHSPERPNPFGKGPLSADAIPLLDLAYVRLFVNLSRSKERFWQRDWDGMAEELARGSEIVQHAEHSPASNADSAVTDPSDVSGANSLFTDSPPTQSSSPEFAASKVSASGTINPALMQQQSQSQPQPSNRSTSRREKHLRKAAFFAAESLSFSDKLGVTFANLTSRELPLQSAMCAFDCAQVLAEWVATLQDRVGRYLGIIGQDDVDLSQVPAIMLLEDEDAKLLGKIQEILDGAEAKMNLDMASNNGLPDGRLHMDDHAGYAAKILRVTAYMFDKSAVWPVTRLITSCLETHANHMRARAEKSVMAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KGB7</accession>
    <name>A0AAE0KGB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_563369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KGB7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="450" mass="46405" checksum="6D003FDF801A5FC7" modified="2024-05-29" version="1">MSGYSDRIKQKLQQTREGLPKVGGGGSGEGTGIRGQLKGLVGRGDDSSERAHHVAQPLSSLRDPASFGPPPRRRPSEPPAHYISGTSERDTSNGGAGHQSPSPGISPSMSSNSSSPRQLPRFPDLPPRLPPRTNMGGSSAYPSSPTTTGGRASPALPPRISPTTTTTSDNNNNNSSSTFLILGNGSQLNQGAISRLGAAGISVPGLGIGRTPLSPPPPAPPSRSPTTTNSPPPPPPQKQLQQQQQQQQQQRFGTAGSLLQSRISSHLPSTTTTASPNNTAAPAAGGGGTTWKQKQEALNTAAALRNDPSKVSLADARSMGSTMNNFRQRHGEQVAAGMREANSLNEKYGGGGGGDEGRIVMFDNDREGVKKEQQQQQQQLSGGGGGVGDAVGMSSMTALIVAKKMKKPAPPPPPKKSAMLGQRYVIPNTGPGDGGSGAPPPVPLGTRPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ21</accession>
    <name>A0AAE0KJ21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease-III-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_477196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="135"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="285" mass="31704" checksum="08CB5B2230C89E03" modified="2024-05-29" version="1">MALNSSSARSALASTTRALQQCQRAAAQPISRPIAQSAAVVQRQQRSLSSSSARRSDAPTRTTDEAVEMVPAYPTHEVSNRPRWAQTPIRMKAPFQISVAKDPRRKIWANNEDPDKLDAMYNRLLGQNGESMLPDEIKWLAVTHKSFDQGRRGFNTRLAYFGRQILALETTRSVLLAPITGNAADKDEFKRKPFTHPALANIDKLSVRHPQKIIDKEKLAKLVRDVGLMDVIRWKPRNPMKLETSGVTVVANTALFAIIGAVSLTHGGEVAQRVVRDKILRKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJX9</accession>
    <name>A0AAE0KJX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_228951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="22479" checksum="6E5D6D7C49C9E4A9" modified="2024-05-29" version="1">MSDAAALHSETWSSPSWSQSQDNPRQTTPSSFQRPGCGFARTTDCKHCRCFLCFAMPCTRYRALIDSTALFLSSELQENAASKTCMHCAASRESWVLLGNKKLPFPPWSVSCGPARLQNHDIKTPHIYKVPGLRREMHYDYLAMGSIGDISESLPFKHAANRQRQLASGLWHHLVVTDCPERRTVSYLGNHQYAPCHAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK14</accession>
    <name>A0AAE0KK14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_478898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK14"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="20618" checksum="E9D2D44CF5C503BC" modified="2024-05-29" version="1">MEQFYSNCVCGVCFPLLFSCAWMQMTSLLSWPMGFLSHAESSRTSSSLWQLGLMLQGHDMNETVNNVVCSNFHSRLSYHTRRGKASRKDNKARMYRAQVRYAARIVAFFRHLPQQIISLRQPTDIFGIRESLQQARHGKIGEGCFLRDNRYHSYSCSVSRDTPLGWRDAILPSSSVGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKR5</accession>
    <name>A0AAE0KKR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase subgroup catalytic core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_248359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKR5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041956090" description="Glycoside hydrolase subgroup catalytic core protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62193" checksum="C883602E6C725D29" modified="2024-05-29" version="1">MKWSGFWLLAAAVAVINCQQTGVHTDWPRWCGKVYQDGYPSFNPGGQTVSPQTAAGAPLVHVQFEPRYSLYLDSETHGEIVVNAELSQYYGKPWPKFNSSSGRANKLIFSVNLVENDDILVQNTVAVNSTGNIFRFDLSRLKPSLEPIKLVLYGGPEGGYPTWTATSSVYYLPEKKQGSVTRIDNLNGGLLFKNAASGNKFQPLLPYGFYASYDGFLRKNSTSEIQHYADLGLNSMTALTTYQDSAAAFNYMDKINLKFMYSLRDAYKNLTYVREQVLAARDAEAIYSYWGSDEPDGWQDPFSAPILARDLIRQLDPYHPVAVTLNCQNYHFAEYSAGGDFLMEDTYPIGINSTWSKWNTACNATLGDCGCDNCQGNVQDVPERLDDYARYERWLGLWPKTKAHNPQSFHGEDYWLRDPSPEEAVVMAALALNHGAQASVSWLWPASEILGVAHGKIGRVLSSSPVVDFVVGGDMPHRISVVGVKGTDVVDAAYWVYGGKMLVSVVNGGYVDIEQAVEIAVPDSATAVESTPWGNVSWTLGGGYLKVGRLEAMATSLVILDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKU1</accession>
    <name>A0AAE0KKU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_479550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042053878" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10865" checksum="0C662EFA6C49D688" modified="2024-05-29" version="1">MTLVLFFFFFAFLSWYRNWPGSGEILKRNCKSVTITLGWPLTELLRQIGEHKIGTYMLFLFLFTDTDCILSQRLSHDLSISALSLLSNDGQNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLT7</accession>
    <name>A0AAE0KLT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_512537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLT7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="516" mass="55411" checksum="B20190A680461653" modified="2024-05-29" version="1">MTRHTPHFMRAHSSNLSLRSLALEQSLASSSRSVNINNIVDAKDVKPEDFTKPYLKFMTENPTVFHAVGYFKEKLAKAGYTELPSRENWAGKLSPGGKYYVTRNGSSVIAFAVGKAYKPGNGVAMIAGHIDALTARLKPVSTKPSANGYIQLGVAQYASSLNETWWDRDLSVGGRVIVRDPETGKTSVKLAKLDWPIARIPTLAPHFGIGMMGRNNAETEAVPIIGLDNSDISSSSSTTEAPLGGAGSFAATQPPKLVKLIAGELGIKDYSTILNWELELYDSQPATVGGLDKEFIFAGRIDDKLCSWAAFMALLHAKSDDDEGTIKLVALFDDEEIGSLLRQGARGNFLPITLERAVESLANSASGYTFGPGLIGQTFANSFLVSSDVTHAAHPNFTQTNLAGHSPRLNVGVALCVDASAHMTTDSVSMAILDRIAQLSGTVNQRHMIRNDSRSGGTVGPMLSSAMGVKAADVGIPQLSMHSIRATTGSLDPGLGLKFYKGFLDNWEKVDREWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2P1</accession>
    <name>A0AAE0N2P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_79909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2P1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="224" mass="23697" checksum="DE412E6478D8013F" modified="2024-05-29" version="1">MSAGAHSAAAGPVIFAPKQKPISTQTCQPPTPNTSNNSADAAAQEAEPAASRRRAASIRTGPRCSSATSATYSPASRPPSRTAAGVAAAAQSNICICGGSGMAGVDMGMLVVVVMTAVLDAAGGWDATTAAAEFRVKGNKMGTLLENAYFGSRRQEKERQGHKLAEAIDDADDDNKREREQPNDTRHSSWEWQKDLQNKLKIIFMNQNPLNICGVVYGGILHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2P4</accession>
    <name>A0AAE0N2P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TfdA family taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_490032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3367933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="39763" checksum="3EBA5CEF88A9B513" modified="2024-05-29" version="1">MGSTAAPLKLMREPLKNGNSIDHLDYIDVTPIIGREYPAASLKAMLEAPNADEQLRDLAITICERGVVFFRAAQDDLSIGEQKYITDMLGKLTGRPKENGLHVHPLYNDPNNQPMADGTNDENIYVINSEAAKKLYATMKDRPAATEPRDLGHEWHSDSLFENCPSDFSFLRMESTPPAGGDTLWVSGYEIYDRLSRPYQRFLESLTATCAQPVFKSACEKGGYAVMSPRGSPLNVDFEFAPHHPVVRTHPVTGWKSLFAGVGLHVSRIDDVTSYEDSMIREYVLRLITRNHDCIARMHWTRGACAIWSNVCTLHAATPDTHLVDGIRTGVRASGIGEVPYLDPASTGRREALGMPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Q0</accession>
    <name>A0AAE0N2Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_489006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Q0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="426" mass="47863" checksum="DB94EDAAE8445FA9" modified="2024-05-29" version="1">MPTLLQLPNELLSLIACELNLRSLLDFRLASRHLNALSLPAISKRRFEIRYVMLQQHSLENLIEISRHRVFGPALKTLTICIDHLTEQPEYGRTIWHWGDSVRMYEEGDLIPGVPDPSLREDSEEVVVNRPAYERLLEDQKFMMESGLNTTYLTQAIAAFPNLETVVVDDAFKPWGAAAQERQTGVPMANGIEDLDSIEFVVQTLRGIVLAIAASNISLYELDIAIGRLEGGISPDMLVFPRPVLRYIQSHPINLTSLCLSVSPRNRTHPNSELVGELLGFITGFPGLQRLSLEFNYREEHEHFPAISQTLRLPGLRYLGIDAVQCTESELGTLLLGHKDSLEEVSFSLINIISEGGSWQSLLATMRDELSIRVLTMENCLSADEDVYYRERGSDDVTYLKGFEISGPRQDWTDAINGITIGNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Y9</accession>
    <name>A0AAE0N2Y9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_529233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Y9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="193" mass="20445" checksum="CBB0070290EBCFFA" modified="2024-05-29" version="1">MQIKKAVSIVTGLALVQTGVAIWPIEFGFPLLVAVTGSMQKRGLIDAPPARGPAGHAARDAAAVAKVEEAEPLFLVRSEADVVARGPEFMAEMMKRASCPAAPNGVPQNVVGNCCNALRGKTLQMNSINTGKTVPDVRVKKIPFPCISAAPWLDGTTQGGGTPPFACGDDCLQWTNLNWDQYNRAKALFQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4L1</accession>
    <name>A0AAE0N4L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_487256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4L1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042189982" evidence="1">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="253" mass="27565" checksum="48DDC3C6E7139BDE" modified="2024-05-29" version="1">MMAFHTKPFRLLSLWAVLGIAIAGAILPSDQHVFSGSFDGTGNAAKVEDKIVKKLKKAEIIPTVIDEFVPSLLLHAKWSSKNKAELGNTLKPSKLDDAPSVSLHAPSDSSSSLCTNVGVTYTVALTDPDAPSRDDPKWSEMCHWIATGVSASTKSKDKNSRCPTDVHLADLEEVMPYKAPGPPEKTGKHRYVFLAFIPANGTTEKLHLSKPSDRQHWGYDTDDGETKGVREWAAENGLVPVAANFIYAKNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5W6</accession>
    <name>A0AAE0N5W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hippurate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_550158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5W6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="118"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3371876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="357" mass="38197" checksum="960814045CF4B3A5" modified="2024-05-29" version="1">MSFSKVGGYGVVDSIENGPGPTVLLRADMDALPVLENTGLPYASTKRIADTDGVERPVMHACGHDMHVAGRLLLLFQPNEEHGHGATRGAPRPDVLAQHIGSNKAGILQIGSGPVLAGKRAFHVVIPGKGGHASAPQDTIDPVVTACHAVIRLQTIVSRETDPSDTVVVTCGTIHAGGASNVIPDRAERTVDIRAFSPEALHKAVESMKRIIKAECVASGLLQEEPSIVETENVPPLINSSDLTERLQEQFNHSFGDGDGAVRDMVRGMASDDFGVPCAYWNLGNTDPALLEEYQRRGICMNFPATNFDRADASGYRSIDIGHSLAHSTDCVDMDAYIFSSSTSRLRPVPTPQDLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N912</accession>
    <name>A0AAE0N912_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_400979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N912"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="615" mass="69416" checksum="C11663E1E5678770" modified="2024-05-29" version="1">MELSTSLTTFDTMSTPGSFYTAKDSPPPLGLLADTSAISSPIEPDDEPPFIPRYRDTTELPHELKSHCQIHIEEEQYAPAILLLEGLLSDGNTMLPRGGRYAATLQRPKPARIPPPSHIALLSTLTIHPTFTSRLVEHNNSIAAQSMKYLRGLLATAGPVHANLCEAFRFSNGRVDGSHNRRWGSSVSGNRSGSPDEESDSIGGKLAVEQSLWQRAPDFWSAMGWAFHCSVAHPHRWRHWKVWLRFMVDVLEKDWDERLAQDQENHALGNGKEACKFPMLQRSLFAAYLDDLRKERKNVLREVIRSLFAFVDNDQASDKVTYKEVFDRETATATSRSKRKRADTVVDLENNQFGDYLDADDFDFSAEEDDSKQRMPKATTVPRARRGRLPRREQRESALTSTSITPNPRGEFGVPEGVAESIPLRLRLFRLLSNASFYIPNPFTSTAELYETFADRVRESPLPIFRLFIESQSDALPREVCVSLLRQIVEQLLPTNRPDPDDVDPEINSIHGLSFVMMQKCFLPFAAVTITAEDNAKLSLGLENILWYMYSQEPGLPGTRLAKAIETGIKARENKIKDKMKRTRTAASGAHDPADMAREVLDRSARNLRVFMDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N994</accession>
    <name>A0AAE0N994_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_483144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N994"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3375507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="29061" checksum="5C4FA7EFCF480A2E" modified="2024-05-29" version="1">MASGYDRALSVFSPDGHVFQVEYAGEAVKRGTCAVGVKGKDVVVLGCEKRSAMKLQDTRITPSKIGLIDAHVCLAFAGLNADARILVDKARLEAQSHRLNLEDPVTIEYITKYVAGVQQRYTQSGGVRPFGISTLIVGFDSGGKTPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNYKEDMDREATVRLAIKSLLEVVQTGAKNIEIAVMAPGKPIEMLPVEDIESYVKNIEQEKQEEAAKKKTGRTPGQGSAAILTRTQDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9P4</accession>
    <name>A0AAE0N9P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_482339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="566" mass="62210" checksum="4EC03582851DC435" modified="2024-05-29" version="1">MNDSDDYQVDEPVIAADDHMRQYMPASFGKKSKEANFAAQIEQSRRQVEKPLAPKRALSDASDSDDDDDSDDSEDEDKFPVSHELVLHTHERAVTTVTLDPAGGRLLSGSLDGTVKFHDFAAMTPTTLRAFKSVDPWEAKKSSALPESHPIQHLEFSKHSGSVFLCITAHPQAKLMSRDGAIETEFVKGDMYLRDMNNTKGHVGEISTGAWHPTDQYLFVTAGSDSTLRIWDINNKRSQRDVIAFKSKVIGTAGRTRMTAVAWGTPAQGGSPVLMAAALDGSLVMYSGNGPFNRPAAEIRDAHKADSWTGGIDISADGRMVVTRGGDGLIKLWDTRKFKEPLVKVEHASTSDRFPMTNIKYSPNSSCIITGSVSGDLHVLNPGNLRPELVTPITPGAPLIVVDWHPKLNQIVTGSANSETRVLYNPTMSHRGALEVMSRAPKKRHIDDDPSITTDVTAGLSADLIITPGAKRNNLTASGKSNDPRRPQVKQITPFMRSQPDEKHISENIPLSRMLHEDPREALLKYADVAKKDPMFTNAWKDTQPVTQYAEVSDDEDGPDKKKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBK3</accession>
    <name>A0AAE0NBK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_232848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBK3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="259" mass="28605" checksum="ED6505004F9EBB20" modified="2024-05-29" version="1">MMNCLNISKRSVGVRATPSRCGITFILFAFQRRTGTKRSFKIFAAKSKCPEQSLLFPTSTPSKMARTTKTRCPIPQSDRAGPQRRTVMADLMFAHLALENLATFPSLLWVYLVLLCFIPAATVSDILSSILSVFHCYTISPSDVILMCYATLSVLASLTATSPLAGSRSDLCYSSRSCALVLGDNFGASKVGQMQAKHRANLDNWYARLRRGANQDHRILRGLIGNSLNKLPRGSMNKASASLCVSVTWRRKTFVLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBX7</accession>
    <name>A0AAE0NBX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial seryl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_234822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBX7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27349" checksum="AA132CAB085ED26E" modified="2024-05-29" version="1">MVLRRFLARGVVQPLGGGGGPRLQLLPRFRFRYHAGKGKRGNSTGSGGGSGSNGASSTTTTTTTTTTTTTRAQRILSRLPPSLQKYTTRLQNAPLSHVVAFLILHELTAIIPVVGLFGLFHYTSLVPIGYMLEHYGAYVRDGVGRFERYFTRKGWFGFGGGGEDGEGGGDITATAIVTATTADVRGDEDGRPDTAVMQRWESTDEKYKIVVEVALAYAVTKALLPARIIASAWATPWFAGTLVRLRRLATASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC60</accession>
    <name>A0AAE0NC60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC60"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="194" mass="21258" checksum="84D658C39FD85231" modified="2024-05-29" version="1">MRLPYVSNPPATSSDEDAAIVARVQARRAPRPLQPLDLALLHSPPVADGWNSFLGAVRTRTTIPAHLREIAISRVAVVNRAWYEWMHHAPLAEAAGVSKEGMALVKADEVEYTIGEAPAEDVLSGKQWVVLCYADEMTRNVEVRGETFARLRALFNEREVVEITATVACYNCVSRFLVALDVGEKNGLGPDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCF9</accession>
    <name>A0AAE0NCF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="449" mass="50563" checksum="F5EF3C6AA75328B3" modified="2024-05-29" version="1">MGNKFIKNAAKALADAQAENEELKRKIRALEEDNNSLRGVSCRKCRHLRASTTPPQSPSSRSSSSASSCSPTKSYMSPTAASEAKTAAPSNTTTPATPSQTAKTIIVNDEPYTYRDGTIVSTKLDPNARFLRDTDSTLTKRWLKRQSHPRAQFDYRRYQTKGKQDADSPDSEGDDGWPVGSGWRANKSAGLDNNFYTANDDPSDGQLSGPECETVGGDSRSSANPSTRPPPEYMPLDETELGIRSGLADEGWTRSGCLAHIYINNEKGMNMLRRAHSIARESFWHAAKVRWPKMWEAHFKDGPGLVKTGYSELELYTGTWSWAREIKRELEAFSQLRNCVCHPRALDRPRQYEIYLTIAHRLVVKLDDERRAMKIRKLRDTLRREAERTLDDLRARAHLAETPLSGSVEWKIQHERLLSSICSQTDTSNYHPDVVRAAKKWASRCGDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCM2</accession>
    <name>A0AAE0NCM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_248934</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCM2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="231"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="448"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="601"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3378493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="691" mass="72330" checksum="F77DC794218F2D64" modified="2024-05-29" version="1">MADQLSAGMGNLGLDSPSGGQLASQQAPLRSYIPPHMRGKMGGPVPQGGPPMGGPGGPPPGAVNGLNSSAWAGNNNFPARDGNNWPAPGGFVPPPQGGGGGWAGGRPQNQGAPFNPNAYRGSAPSGNVGGGGGGYSRGGGSGEGQWRDGKHIPGNPNPRLERELFGTADDPSKQHTGINFDKYEDIPVEPSGRDVPEPVLTFTNPPLDPHLLTNIELARYNVPTPVQKYSIPIVIGGRDLMACAQTGSGKTGGFLFPILSQAFTHGPAPQPTQTGYGRQRKAYPTSLILAPTRELVSQIHDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLSCIQYLVLDEADRMLDMGFEPQIRRIVEGEDMPGVQNRQTLMFSATFPRDIQELAHDFLKDYIFLSVGRVGSTSENITQMILNVEDGDKRSVLLDILHDQREKEADGGDPNLTLIFVETKRMADSLSDFLLNQNFIAAAIHGDRTQREREAALRDFRSRACPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGTATAFFNRGNRGIVQGLLDLLKEANQVIPSWLTNIAQESSFGGGGGRGGRGGGRGRGRGATSDFRKHGGGGGGFGGAPSGGGFGGGGGYAPSSGYGGGGGGYGGGYGGGGGGGGSYGNPGGGGGQSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG51</accession>
    <name>A0AAE0NG51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_474541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="384"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3380892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117807" checksum="981B7AAEFAD09472" modified="2024-05-29" version="1">MASSQSPQRSEGIVAEGFSVLHSPDHATFDIIFVHGLGGHPYKTWACARTDGVPASDNATPHQGKKKKKFRRMFRRPHTGLGNQYPSASSNESLVNPSSSSSSSSSSRESEVYWPRDLLAADEACCRARLLAYGYDSKVTKGFENVNQNGFFAHAKDFLYALQREKPPRRPVVFVAHSLGGLIVKEVLRRSEASEEEEIKDIVRSTKGIIFLGTPHRGSPEMASLGEVVRRIISFVLRVDSNPSLLRALGADSPELELGRESFVTLWRKYNFRVKTFQEAWGVTGVNVGSLNSKIVPDASSTLDDPREHAESIPANHMDMCRFRTCLDVGYRNVAAEIISHIDGSFPTWRTDETGKDEMGFLASFAFDEMNHRRQNIQSALDYTCNWLYSTSEYSDWISRRNVANDHGMLWIKGKPGSGKSTLMKDALHRAEFNSTGRQCTTAGFFFNARGTEDLEKTPLGLYRSLLHQVLIQDKLALAHLTPVYKAKTVTLQPNDKVAWHESELQNLLRRVFATSESRPATIFIDAMDECDDDQVRDLVRFFKGLARKAWQVGATLNLCLSSRHYPHISIDGCPEVVVEKNNRDDILRYIVSEAEDNRPIRDIKDQIFDRSSGVFLWVVLVIAMLRKNGRGKSQKWLEQKLSEIPPELDKLFKSLFSQKDDEEVAEMADQTTRLMQLILFAKKPLTVGQIHSALAFGRTPYESFEAWKDSVGYLETDTKRHELVIDLSRGLLEEQPSARLTYQFIHETVREFFLSGAGFSLLNFKAGNIVGIGHSTMATSFANYLSVGEFSFSSQDTSPDHLLHGPEFELLDYISYHLFDHIEAAERNNTSQEKVILQLHDDSCHLLRRLTRHRDRIWFKPGFTILMSAIRCGAIKAANRILDMGFDVNEPPQTSRRMYALHFAVTCDDKWLRVFGRQSEDLEVKLETTRLLLSRGADVNLQDAFGDTALHIAATESLRLVEALLEKSPHVNVQNRNGQTPLHRAAENALQFVLIRKMLLEHGARDDIKDVWGETPSAVPFDDRFKWIAAGDGVQSNPFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGM7</accession>
    <name>A0AAE0NGM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGM7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="102" mass="11549" checksum="1BE7A999266B341A" modified="2024-05-29" version="1">MALYHGVAENPQNRTADPGIHPVVGAALHNLTYSPLCSLPDHIRLRIMTQAGPVSLFCLRRTSRIFLRLFGDRRFAEFHDKSSPRGEIVHDGAVRNYFRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGN0</accession>
    <name>A0AAE0NGN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_450562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47246" checksum="BF89AF2EC0C77A35" modified="2024-05-29" version="1">MGGGCDPSLADRSGKSALSVLVKFRFANVLASIAHEANVTKFDSIEGADLEVLNQSGQTPLHMALETISPYELSPDMRLDPPVDTPKKTWEYLQSFGRVKPHEKYPLYAAATCRTPMNEGEGRKGLRSGAEMIRLPLAHGANPYAHFRGPGGPRTNSTGSRSIPGGSDESEEEFDNLTVIHETISLSQNSRTAYAIEPFLELQALDLERRDSKGQTLLLAACRSSLAEMVSVDCGGGRQKDQLLVEVLIDRGADVAASDNKGRTALHLPFIFLSGEKQIPQDSLQAGGSHGNSVARQKKNSDERTPWQLLEEAGADFMIDNKGRNLLQVVAQREGSEDWFEAFISKGLDPASQDNDRLSSLDVAAACGNEIILAMFEKDGDKKVARLKDRGDSKTLGSTDTLTTRRKTTCNNFWEDDKGFSHDPLRFGCRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHJ1</accession>
    <name>A0AAE0NHJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_211145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHJ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="11">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="129"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="D-3-phosphoglycerate dehydrogenase ASB" evidence="13">
        <location>
            <begin position="351"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="607" mass="63864" checksum="66D7DDD8569CA382" modified="2024-05-29" version="1">MAPSAITEMSADTSHILGPAVSDNRPRILVPEKVSAEGLALLRELYDVDTRTGLTADELIQIIPAYQGLIVRSETKVTAAVLAAGQKLRVVARAGVGVDNIDVSAATANGIIVVNSPSGNIVAAAEHTVALLLAVARNVGRADATLKAGLWERSKLVGVEVGRKTLGIIGLGKVGMKVARMAIGLGMRVVALDPYASADMAKGAGVTLVASLADLLPQVDFLTIHTPLLASTLNLLSEPELKRMKKTARVLNVARGGVYNEDALLKALDEGWIAGAGLDVFTAEPPAPDSAAARLAAHPKVVSTPHLGASTVEAQENVSMDVCTQVLEILRGGLPTAAVNAPLILPEEYRRLQPFVRLIERMGGLYTQHFASGRSAGMIGGRRFELVYRGELASVSNTRPLFAALVKGLVSSISDAGGRDVNIVNAALIARERGIAIDEKHVRDDTASGTYASLVTLRSSLSVDDSSSNNNNEQIIEGYVSGNAVFISKLDRFEAHFQPEGTLLVLHNYDQPGKIGNVGTALGRHGINITYMQVAGLNQEARKLADAAVVDGPVLEGEGEGNGNSTPTNHPAKEALMILRVDGDVTKDVLEDLGQSEGILHVSLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI25</accession>
    <name>A0AAE0NI25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Siderophore biosynthesis enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_216395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI25"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="25797" checksum="D29A04C8EA71717B" modified="2024-05-29" version="1">MVGQSRLSGLGAGAGAAAILFLGFAPAGALAKTDYAGCTSTEVLFNQIYTSILHFLPDTGEICQYVDCGGGRAPPKTVPGCPAYKGTDTVTPSWYAGYTKVGGRPAIPTILKTPPVAILPKPEQTSTPAAVTTTGPVTTVQPPPAVTSDPAVESSSTTNAPTAATESDVLLTIQTSLPSSAASLSSVPPALEVSSSAAVSSGFLNSTLSTSSSSTSRRTSTTRTSTAASTTSTSTGGAAAPTGAAREVLGVVAGMAVLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNY2</accession>
    <name>A0AAE0NNY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_559683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNY2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3384973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="277" mass="30716" checksum="65EB251A06E7F133" modified="2024-05-29" version="1">MSVVSLLGVSVLNNPARFTDKYEFEITFECLEQLEKDLEWKLTYVGSAQSDNYDQELDSLLVGPIPVGVNKFVFEADPPDTKRIPTDELLGVTVILLTCAYDGREFVRVGYYVNNEYDSEELVNDPPTKPVIEKIRRNVLAEKPRVTRFNIKWDSEASAPAEFPPEQPEADLVVDDEEYGAEELAEEEEEDLVEAGPAGANGGEPVDKDAEMAGVENGEAEAEIVGEEDEMSDDGSVDIEGESEDELEEEEEVEGEAADGDEMEVDKPEPPKEVMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPP7</accession>
    <name>A0AAE0NPP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_472810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254118" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3385378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="326" mass="35044" checksum="3746059CAB1EDDC9" modified="2024-05-29" version="1">MTLPKTLVLLISAAALAVAQTACTLPSTYRWTSTGALATPKSGWVSLKDFTTAPYNGKHLVYATTHDSGSSWGSMNFGLFTNWSEMASAPQNKMTQSTVAPTLFFFAPKNIWVLAYQWGPTAFSYKTSSDPTNANGWSSVQTLFSGTITGSSTGCIDQTLIADNATMYLFFAGDNGKIYRASMPIGNFPSSFGTSSTIIMSDTTNNLFEAVQVYTVQGQKSPLYLMIVESIGGNGRYFRSYTATSLGGSWTPQATSESNPFAGKANSGATWTNDISHGELIRVTADQTMMVDPCNLQLLYQGKAPSSSGGDYGKMPYRPGLLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPW5</accession>
    <name>A0AAE0NPW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_183654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPW5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="749" mass="78776" checksum="48DD33D6D93BFB63" modified="2024-05-29" version="1">MGSVSLISEALLGGCASFAARIAATSHDLDELIAMVQAVDRSTTQLLAQLKMLGTTVSGLQRLLRGDNATISDSAQDKMRSSVAAGLAVIAEIGDHVKRIIAFTTEENTVASSSSRRKRLSNITSTSFRRPSLQLASSSVAAMWSEQGVKDYVRMVATQCQIFSLFNQLTALNNPHFQDSVLETGESLKILYQGSRDAQAVHEMAATRKEAAEAKHSQSAATTQLTLLGKFPPHPAVCHQGGGGGASEISLASTASSNMGHSLGSRLSPGVSSAASSSSTTGATAPANSAQKLRHPSSRSITRIFSGWKNPSSSSSSGGPKQPTADPKLLFSQLCQACRDGDLEWARNQVSEGADVNGIDARCFSPLYYAVLQGNLDIVKLLVANKAQVGGSDGRSSALVFFAVRKNNIPILEYLLKEASAPVTSLCCESRDRGSWRTPLSLAVEQGRLEAVELLLGYGADVHGGDESTTMASNSEILTPLCTAVDKGDEAMVKLLLRFEARINETASATEWGSHLAALHIAAYRGHDAIVSSLLDAGADISLSCRRGSTAGVTALHLATGRCAATLLDRGAKIFARDSSGQFPLSGAVQVRSVESVQALLRRGVPVNAQDGEGDTALHIAGRVFVRDVKAPAGGGTATSSSERLAACIAVAEELIAGGANLGSRKATLKLVRKECGKLLLQHGGAGRPPPPPPPEDIARIELVELMRFVADTVRTQQREARRQQPGTVGSDGPLWLLAQTTLSQLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPY7</accession>
    <name>A0AAE0NPY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_182451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="37893" checksum="7A2A333C78F7CF06" modified="2024-05-29" version="1">MKTPGWCWNRVVGPAVVIRGFPIAERRKDYHGLEIHPCQMAAFIGLSSAVAFDGGHILKGRFHALVPIRRDRDSPADQLDIQWHVISAYPKNLQWDDIVEACPDGPFQEDDPEELWNARSFFGWTKDAQFFLGTGKCAFNLENGSTAKTPSWASETLQSIQMNKATLGLSYLGKAEVEYCEGLNEGVRAHARDGDLTNIVDDDRTLPIVIYGTTDRRGVQCTAEDLILQLMLDRTRKGGSYDEDLHLATASPKRVQSAIEKNVNIVVRRTHLVPMDTKDVIKGKFDILFKQEADDIYRILDAMMANLHHSRRLGSPMARAKSRLKGGSRVWGLSIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ23</accession>
    <name>A0AAE0NQ23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_560183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ23"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="38776" checksum="80802369D9E0C7A9" modified="2024-05-29" version="1">MAPTASLPTRKLGKTGREISALGLGLMGLSIAYGSVGTDEKRFAVLDRAFELGCTNWDSSDLYGDSEDLLGKWFALHPERRADIFLATKFAVTITVKDNLELEYGCDSSPEYARTACERSLKRLGVDFIDLYYIHRLDAVTPIEKTMEALAELKREGKIKAIGISECSSNTVRRAYKIAPVDAVQVEYNPWQLDIENATSTNLLATCRELGVSVFAYSPLGRGFLTGQIRSINDFEATDFRRILPRFSPENFPKNLELVKKFEEMAAKKGCSSGQLALAWLLAQGNDIIPIPGTKKIKYLEENVAAAFLELTSEEDKEIRAFIESIAGDISGERAPENFFTQWSDSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ63</accession>
    <name>A0AAE0NQ63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_473295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ63"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="613" mass="67016" checksum="02A610880D02A7B2" modified="2024-05-29" version="1">MDPVTAISTIAGVVTVVVSTTNSLRQLISSIKDSSDVMRAIATELDGLADILELTKKLITARKLRKGDVYVIEVVQRSIKDCQKPMEKLLLIIEPLLQAPEEGVGSFRQKRIDLVRAMSWPTRWNEIKAQKRALESQKTNLLMIIHLVGDYMAGKSEDAIRRDFARRFAQEVRRPGTARGRRMRAKLEDDISTIVGSRLEHYDTDEDDDGGGDENHIENDDQTGTILPIHEPRNPALAFLKAITAGDTDTVSAFLKSGTNPSRRSPDGSTPLHLSARLDCRPTATLLLDHGVNINAKDGEGRTALDIAARGHCISVVSLLIERGSLLGTLPHDILTTVGIDGQWKPALQSLAARSSSLDQARLIHKAVEAFDLPALSLLLEAGFDVNSSDRGFYPIHHAVMQGNLPTVELLVQHGANVNQRVTSGALGVPRSDAIKELTSVRDCSYDSSPLSLTVDNLEVFEFLLAHGADPDLPLEPPNGTPCLNAICMNKFFPFAKAILEAGADPNRRDEAGRTPLWWCIDMYNIRLMRELIQHGADVNARLGDGVTLLHKAVWDNRFLEAELLLQSGANAAARDFTGHTPLQRAEKDGRACDELITLLRAHERSGGGGDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ86</accession>
    <name>A0AAE0NQ86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ86"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="35967" checksum="627E924720E59DA9" modified="2024-05-29" version="1">MKWLSVAIAGAAPAQAYLRFGCGTLSVQRLDPIVEPGKVPSAHVHQIIGGNAFNASMDPKVDISEKATCTTCSFTEDLSNYWTAVMYFKARNGSYHRVPQYPNALLGNLVGGMTVYYLQQDFNSNGKQKITSFKPGFRMTVGSPTSTKDGNPGLRYTCLKDVMTRFPETAEFPKEPCPAGIMAIHHFPACWDGKNLDSPNHQDHMYNTGKGGFVAAGACPSSHPVRMPQLALETMWNTTMFNDKSLWPTDGSQPFVWSYDDSKGYGTHADYLFGWKGDALQRTMDSTPLLSNGLKTQSVDQANKCSIKPSVQEKIDGWLDHLPGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQA4</accession>
    <name>A0AAE0NQA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27 cytoplasmic protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_414823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQA4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="436"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="819" mass="92458" checksum="20804274B4E0FE8D" modified="2024-05-29" version="1">MFVLRNVGKLLFGSSNEESMIELPQGQLYLVRPFSPKGYSELIFKDSSARIRRTAQDFQYQLVIQRVYEEGEAELLAEEEGEDAEADADILASERDEKTFLLDEALHFRVENREGSEKVLAWRDLSGDAGDVYEFVCDTNISPAQVEQFDAIAKQCQYERKYRKPHTTASDEDLLQFVFDDEQPIPQASPLHSPTLTLTRSIESSDSMFETLHGANTSAKRDKAPEPEAATPVKKKERDARPPKVVPAHPEATEILAAEIAELHFFDFPSGAFVLQDGAVTATVSEIGKWQYWLKVGSVDRDWLGIPITADINPVFNFDFLSFIFNQFADDGSAYSWLLRFKDQPTLERFQEGLLQALWEQLNEMKWSKVKDTERDYIADAFQDMTMEDANHLEGVQEEDEEEEEEDKEDDRARSEHYDSDEEDDDREYEPKDGEVNKSIAVGYKHDRSFVVRGSKIGVFKHTPNNHLEFSTNISKVETPKGELFSPKKVMLHNEDRNLILQKDSDPNSLYRMDLEYGKVVDEWKVHDDIPVVTFAPENKFAQMTHEPTFLGVSHNALYRIDPRLSGAKLVDAQLKQYASKNDFSAIATTEKGYIAVASNKGDVRLFDRLGINAKTHIPALGEAIIGLDVSADGRWVLATCRTYLLLVDALQKSGKNEGKLGFEKSFAAAEKPQPRRLALTPEHVAQFAYETGKGVSFTPAKFNTGEGIEESSIITATGPYIVEWSLKKVLGGKKAPYLIKRYTDDVKADDFKFGTDKNVIVALPHEVNMVDRARLKRPTRESIAGDFVSAGRRSSGRVNTRESGRYKLGKDDVVQTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQM8</accession>
    <name>A0AAE0NQM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_544223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="37351" checksum="FE52AF4509276267" modified="2024-05-29" version="1">MGKCREDVCLYIVMEVRPRAEENERELKNKPLNDRRGVSDSALLARRQAWTKWVEFIKDIRNLDPNETILNLCRGPIQQEQAKLRCQNFLCYYIESSERERPNDGPEEVVHELTVTSTTTVLEMWKALIMYADTNVLQRMRRRDPDNSAQWTLSIGVGGPRIKGPVFEISTWIVEVLSANYNLTNQQKFEKHEAAAEDILLILNTIWYRADLIKTTPDMRLDFCIVLLLAGITSFRPGAITNVYYHQVEMAAVRDPADPAQTKIIATITLTHNKRRAKALRKSQDHISGNFGIRPFRYWDSDKIFVLTQLEQPRAGDSQLGSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR12</accession>
    <name>A0AAE0NR12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_473893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR12"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="7918" checksum="6422F6746E2E798D" modified="2024-05-29" version="1" fragment="single">MCTESQCRESRSVFGRRRPFTASAIIFTLGGGLAGGVNNSSLLIAGRSIYGAGAGANVVFLDIPYADIHSLGLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR30</accession>
    <name>A0AAE0NR30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_544726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR30"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6606" evidence="2">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="559" mass="62642" checksum="C02ADC90A2B97236" modified="2024-05-29" version="1">MAATFYIIMPAALCNWTKHKLPTDTVLLHVRAQNAGMLLTRKHDVMLVEAFQLLAGSGTVMACADRLDRKFPDRAAIVPLKAFLDPDFFAEFTRILLASLVCLSTFDIDQGYLVVIMYEAREMISTKVRLGKNTGLAEGIARFWPDFKTFPSSHVAPWTIESESSKHILQIESYQETAAFQRLFGSEVFDVVPATVSHMTFSTRQPKAGWILHFGTQLLAKSGKVVIQATQQRTGETDGERDTWEYLPTVLFQGFIPAEFVDDYAQWYNLRTGEIEFRPIDQLLTTSRKGLGSFPCDIWVTADYASTVQPPHNVDTVKEFCMDMYQRPVQCVLTSALPNEPMQLVVISPAEASELKPLLLANASTENKGVVPEAHLHLYKPRQSHSLPPLDDLRSYMIPSPLPQGWDAPQDLIMQLNLFAGQLYFASYEEYVRLCRFLGLTYQPNQSSHDEDGGVDMEEEGEQTASATAAQGAQMVIDTDGFGGKKLYLECRFHISPVPFLKEVLQVVRRYGGGIGKTHVGRMLSGEILGPGEFKMLGRASQFIWKKGFDLLIYKLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRI3</accession>
    <name>A0AAE0NRI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_523495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="66"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1102" mass="125818" checksum="879E79B2498A3343" modified="2024-05-29" version="1">MAGEYSVSDEVIYEELPVENQSSEPPQGEDDEPETPEKGYHALQDEILIYLINTAALLDTGFQRQLKDAWNKLAKGRALRFTISSMERMFDTLVEKGDTRVSGDILDKLKQLIAARTSVHDMYAAVTARMRHGNTTVPAHMVQSNYGHAKIIAVFENMLDDLKWKDHKVKRKFQRERRRESCNSNDPAGNDRPEIEDEDKDGDQPGGQEEAQPVTQDNPVTLGPSPKTQPVPKPNTPPVYRRGSECKANDTPAITQQDAEEYILNTFMEMSVITEKTLAHWRTYAEITDKFQLRVTYKQYPHMDSQELGILTMATFDMFQQLDDDICKACQAGHGSGRTNLNPGYEACMAQIIADGHLSASEDEVRLNKFIEVPASRDPNRTGTTGSGRKLSLIKSEAFGILSYVSLLKTANDFLLRCNDTRATGSVGILTTIPPDPERFSTHKKDWLGDVIAEEWEKQSLTDLLYDIYYVAKGKEWGWVPPVTPGESDLLLLLEDCMRGAATIGSLGIIWIVFAFQIVQGVGEMIYYANASFAARHEMYEETARTKSQPCAYFEYKEDERVAAAIRELDRRGVTVLERGDTTDPNIIEDYRNYPGHDIVTLSMIRARAMLLLCEFGMQRAREDFIIEAAISIYRLVRVAYGRIPGAPNWTIARSKQSPESHYWSTYSGPLRLMGEWVPGNLFTRVNAMPTRAQYDDALKHKKTCSPEQMARPILQRFTSEADRKDRTVVQWLDEFAYASVGYSWSCEIKEEKKIAERNTLRTYFRTEIKPDRNERRLQQVDELGVIGRWLAVRNGFAYGSDLGKFLSFDFLGLYRLSKNMLQGLRKTVKIHHKKMRTRDCMWGDDNSTTSSLARIPTLFADYIYKCGENGFRKKGLTGKKAAREQAEEKVAKMCLRAVKQMLADEKVYYQNQVKAPQLDIPADMDHRNLKVTRVPGMAPKALVSGKWKLEQIAAPKERQLAAEEVIYEDLEALGAELARCGWPEEDAYETHLKPRKHELEYLIERQRRAQEERETSAHTREITPDMLVRLAEGGDVSPPMRKKLIKLGMMQNSISMNQFKAQLQAQARKFELEWVNSQFRKKKLKQPEEREESEESDIYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRJ7</accession>
    <name>A0AAE0NRJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRJ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="438" mass="49254" checksum="F21C300CF0C4BEA1" modified="2024-05-29" version="1">MGGIRPHTGPPRKTSCTPFIMAGISGTSSFSSVASASSIPAVDRRTLPSHFTDNPDLAASQRHPFFDPAVHDEGHVLELQLLKFKPQDFWLLTPAELVKQIKHSWSSHNCHATTFKLPIHLGFMNVTKIDPQPLGSPEWWNTDTATSTMWYKVAQANVEEMPKERATKYPKIAQNRQPGQTLAYHPQAHAFTSIQDYAALLNYENTEALAQHTDCEVADYFGPLAALNEQAARFDSWMNILKSIPGQFTTSPGAMLFNSLAHQDNHTLRPVILRRGDMQDPTALSLEEKHMVATTPTVVATLLIYLKMIRTGQNGTGQPRYTQKWGPVAYTYGGYYIDDWLRAIFHMLFFLYRRKSKSPLDGKLGVREPASKVYVFKKEPCVETSAINESSEFVTPSPAAARPKRKPMAQLRPAGLKRVRVPTPSEERDEWEMDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRS9</accession>
    <name>A0AAE0NRS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="14802" checksum="6AA12071518875FD" modified="2024-05-29" version="1">MELKFTEIVLSLMSQDRFNPFVNVSLPCMVESRVQRWQYRPFWLAVPYGIAAGVALVAVVAGAHAFWIMGYSLGKAPLRKHVLRNKLPFGDITGTTMTSGRGCGDDTGTSTGVARRAGFGSEANVYPVAFGERYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS52</accession>
    <name>A0AAE0NS52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_520773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS52"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="103" mass="11547" checksum="F1C0CE5CA1E3A7B2" modified="2024-05-29" version="1">MSTRSRTPPPRPSRIIHLRQSARRRRPILLALPAGPSFSLRASIPPGPVITRLAISSTACKESRLVMRKSAEDRDVITGCFKSSGQCFQIQEWDLVCLQGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT18</accession>
    <name>A0AAE0NT18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit 5 C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_468847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="349"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3386999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="512" mass="55002" checksum="14F8CBEFFA8382BD" modified="2024-05-29" version="1">MSNSFFQLPDELVLTTLAQAFPCRDSQIRALATLVYPRAAPCQNIVLHGTEATGKSAMTAALLDTLQPLDGQTDDNASLRFAIVNSTECITSRHLFESVISKVADALRWDGAPSRCETASQLTVALSKMLKYTPRPDGFRFVLVFDGIDHQREAPPTLLPALARLSEIIPCMTTIFIVTSPPANFLRTSFVPHIHFPNYTKPEFVAILAATDPPATLPGTTPEGTTDLWARFTAAVHDALARAASRTLPAFRHACAALWPRFTAPVVAGTHGAREFSKLLIAARVHFQEEKLLDPGIVAVPPSQPPTTTNTTITNGVAAANHPPKLQPLPLQQKVSSSVQHAPDLAALLPTTARLLLLAAYLASHNATKHDLVLFSTHHHGRRRRRGGLSVGSMGGRGRGGGANKHRKIARKLLGAHAFVLERMLAIFAAVRSEWDAKSRAGMAGGGEAIDADIGMAIATLASLRLLVRVGGAAGNGDPLDRGGKWRVNVGWEVVRGLGRSMGVEVEEWLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUG7</accession>
    <name>A0AAE0NUG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoD-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_542450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF8">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041903778" evidence="1">
        <location>
            <begin position="21"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="197"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="616" mass="69130" checksum="7671CB38E35E3632" modified="2024-05-29" version="1">MTLKAALALSGFMFLELTSASFSGNLNYDSPSKRHDHLGIDIDVVSRRTLKRGSVPFLPSQLNFTHGVASGDPYPDSVILWTRIAPSDASDKSNTTVEGTVPLYSHETEKYIKADANPICAEWKVWEPRDKGTMVAEGTAYTTSDIDFTLKVEAKSLKPFTLYNYQFTVCGSGKSSPVGKTKTSPSVDDDTVKEIKMAVFSCSNYPGGHFNAMGNAARKDEHDFVIHLGDYIYEGGRQGKRPHNPPRTALTLWDYRTRHGQYRTDPDLLLLAQNSAWITTWDDHEVSDNGWRDGSSSMNNTEQSFRNYGFGVSVDQRKMNAVRAYFEWMPIRQVELDDNLRIWRSFKMGKLLDLVMLDTRNYDRSITGVGWNDAYIKEIHNDASRSLMGSRQENWFYRTLSESAKRGATWRIVGNQVLFSQFVDDGGGDSWGAYAANRNRTFQHLYDNKINNNVFLTGDTHRNWVSDLAWQGAKKYDPATGQGAVGVELAGTAISSSSPRRSLESSFIRGKHLIQANAQLQWQESYYRGYFLLSARKDKLDAKFYGTPSIATRNSWDLPLANFTVIAGENHLARPVAGGKVETGYLRSGKTVSTNVTLDTSAKTWKVVGIENMYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUK1</accession>
    <name>A0AAE0NUK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_542495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUK1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="41977" checksum="431CE36A2E8D1AB2" modified="2024-05-29" version="1">MARRLVALTERSYQSANKTALITDSHHGKTGADGQDGSYLCELLVGQGYTVHGLVRHHSEVHSQKPSRRMGTGAAVQHHYGDVLDPFSLIKILRLASPDEVYHLAAQSHVGLSFSTSSYTSDVDALGTLRVLEAIVALGMEKRVRFYNACSSEVFGDVKERVQNENTPFNPRSPYAVSKLYSYYTTVNFRDQGVFAVNGILFNHESPRRGMDFVTRKISRAVALIHHGRRCVLTLGNLNSYRDWGHARDYVRGMWLMMQQPEPEDFVLATGETHSVRKFVEEAFRMIGIDIEWRGKGVSEVGVDASTGRLLVQTDPALYRPLDVGYLHGSPQKAKEVLGWKPEITFQQLVREMVMADIRALEDGSDLRAIEGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUL4</accession>
    <name>A0AAE0NUL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_393284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUL4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3388037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="380" mass="40224" checksum="067EF6436D938105" modified="2024-05-29" version="1">MATRPPSLPTQMKAQFLDAFNTSYALRSVLLPTLTSAHDILIKVDAASYCHTDAVLGAGKMPPNPPSFPHVGCHEFAGTVVSIPPNFSSPSSFKVGDRVGVPGRAFHPCGACFECSSPEGPDADPPGYSVYCPHSKNNGISTDGGFREYAVVDSRQVAPIPEGMSAVDTAVLMCAGVTIYAALKRCGLIPGQRVGIMGCGGGLGHLGVQFAVAMGFKVTGVDNADAPLKLARSVARGATIVDAREQEASEVAVQVGQEDGKKDRGDMGLDAVIILPESQRAFDYGVGLLRNHGKCIVVSFPEQGFHLSSRDLVFRDISVMGSLVGSNKTLREMLEFATKHNVRASVRTLPLSKLNELVVEYHKGEGGKLVIDMALPDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWV8</accession>
    <name>A0AAE0NWV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_95800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042096014" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11713" checksum="BACA434C9BCBE307" modified="2024-05-29" version="1">MSSALLPGTTGPCLLVASLLCLPLSRLAGFPHTRECSSTEFQVVGLPSQSGTLEISHRTPDFAIIWASDHGSTNLSSPCHKLSAYVPASIALEVDLLHEDSLLAVAAGCHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXM1</accession>
    <name>A0AAE0NXM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metacaspase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_98952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34823" checksum="9562F90DD7E50DB2" modified="2024-05-29" version="1">MSSRSKLKLTKSYGAVRIRKLVASTAETEPPRPAEDVDCLPTHSNVTSGLQRINLDASAGDLTYIHFIGHGTAIEPTSPFASRGMGELALVVPARDDPTNKVQYLRESELAYSMRTMVVAGLKVTLVLDCCASGSVARDKLDRSVCYLPYDSAVDVAHPPDAERSLGSDEKCGAIRTGDRDTSLRQNWLVDPDGYTILTACGPTEIAQELNVNGSWHGALSYFLLRVFARNGRVGGKLRRIYPQLYARIKESWPQSLPRQKPMLYGNRNLCFFDSDTDQGYDAARIAVISRKGGRLELEADQAHGVCVGDEFVPQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYZ6</accession>
    <name>A0AAE0NYZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">B0H63DRAFT_446298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYZ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="337" mass="37199" checksum="63DBD68FD3347770" modified="2024-05-29" version="1">MDKNLDARFERVEKALANLIDSIAKYNPSEKLAEGLVEADKELFKGLQALETHQNNYARIQQLREETAALDAQTKEIIGALWTMRKEVKNTQTTVYPASGPKYQFTTKELLDYARRISPNTLPPPGVTNGVDFGTPTPTPAEQPDDAAKGGGAQTPNTSFNGTGTAAGTPAASGAPPTPSVNGDMSSTHAQPPGFVSQTSLTSSILSDLPPLFKQAIIIDEGAVFVPWPDEFYIRSGALASYQALVDRNIDPKGYDPEEEEQRRKEEEAARKEAEEKARIEREEAERRMREERERMARERERNRAEAERRGSVATGFVPPPKTQFTFLDAGDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ28</accession>
    <name>A0AAE0NZ28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ28"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="134" mass="14873" checksum="D30E2318A0DAA45D" modified="2024-05-29" version="1">MAMQKEYQLPGGVIDPNEEHEAAVIRDMQEETGALIKLRTHLGCVATTEEYRNDLHQMSYCYVADIVNASGDPSLTEDEIADGLGHLWLSVEEAKKRMAEVESTSELGRYIKKRYLSVGGGKQSHTGVESGWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ30</accession>
    <name>A0AAE0NZ30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ30"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="222" mass="24437" checksum="90BF609BDEE1A082" modified="2024-05-29" version="1">MSDEATYRDSSSPRMSSSATTSSSGISFSSRCPYRVLGEFADLISNERFVCDYLLHAIINCHAPGQEINGTRKMFYAKVFHNWDTTMPVEALVSASRPLCHPQLEGALFVGYLRAETPLPPEVERTTKNYYIPTTHTKAADAAAARGECNKRRRACEAYLDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDDKNDENSNDDEGSSGAAACCAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZB2</accession>
    <name>A0AAE0NZB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_538698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZB2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053893">
        <property type="entry name" value="PRC2_EED-like_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22038">
        <property type="entry name" value="PRC2_EED_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein EED-like insertion" evidence="7">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="52618" checksum="4337F13EEB96B2B3" modified="2024-05-29" version="1">MSVLPTAGNHRPKFFDVKFYPYNPVGASPIFAAISKKHVVVCRLSQINDRDTNPCEIIQVIRDDDNDASNFACCWSKDPETQRAWLCVTGNGAKVKVYDVKAGKLVKTLVGHGGDINDLATSPLNPQIIASASDDTTIRIWSLAAVHAKQPCVCLLGGEGHSWDLLSVAFHDTGRYVLSAGHDQVINLWTIPEPPTEHVDAPIVVHYPHFSTSEVHSNLVDCVAFFGDLILSRACHEDSIVLWRIAGFSSDDPPPTFFDAPTTFDPSRQTRSAFAPTTTAAQPAQFTRLMQFYTPDCGVQFFMRFRMYHAPGRHPILAFANAKARTMFWDLERFTTYSRYMAALKDAQRDKAAVPPEKPSWLIVKKNSKKPENASNLRNLAVADQASMVSASPDPESATTFGFNQKTLAEWAELYDTSNARGMIKPHRVGQIEGAFVGRQVGWSPEGDWCVVVGSGNRALIYQRWAKDIKSSTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0C4</accession>
    <name>A0AAE0P0C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_388645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="565" mass="61556" checksum="8F160CC9D8221483" modified="2024-05-29" version="1">MDAESSEINETTRLLDSSSPSPKSSPAQSNEPNHDEVNPTEHETNTSQKHLQTWDKEHRKNLVLLLGVFIVNADSAILISLFRQIASDFDQLASASWILNSYVIGTIVTQPLFGKLSDVYGRKPLLLLAYGSHCAGSALSGVGLSFGALLFGRALCGIGHAGITVLISTLIVDLLPIRDVAVWRGYVYAVNQIGRAVGPPLGGFIVDRLSWRWTVLYQVPLNLVGLITIWWKMTFPPPISHTGVDVTSWEPVTSRLSKLGRIDFSGSISLGIANVSLLLFLDHLQKRAGHSAQDLSVVVPLSTWVGFLAIFIVLEAAWATEPILPLRLLIRRNVVSAYGIQFFQTAAMMAFYTSITLYFRVAMQDSSTAAATRLVFAMLGTITGGLISGYLIRRTGRYRMVTSVATVLSNIAYLVIFLRWRGSTGWLETLYGFPVGFGFGVSLSAAFIGLTAGLDSSEVAMSTSGFYLTLNIGSLIGVSSASLLVNSFVERVLKERLCGIPGAAKIIRDVSSNLDNIERLPYQIVMIVRKTYTESLVIVWLFSLLGGCVGWVASLVMREGQLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0K9</accession>
    <name>A0AAE0P0K9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_466634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0K9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="30996" checksum="1B55FEE861FDB382" modified="2024-05-29" version="1">MSFTRLVRFAPKGDDSKVLIGEPVDRSVDIGAAVRKGEEVKVKVFSGSSVLEAGEPTDQVAVIGRVLSPVSQAEVGTIRCIGLNYKKHAEEAKMTIPDIPTLFLKPATCLADPWPAKTIIPKHTIASDSADYESELAIVLGKEAKNVSEADALDYVLGYTACNDISSRASQFAQTQWCYSKGFDGACPLGPTLVSPSAIPDVNKLHLKGIKNGKVLQDSPLTDLIFSVAEVVSFCSQGTTLPKGTVIITGTPAGVGFAKNPKELLHDGDEFVVEIQPYIGSLYNVMENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3M2</accession>
    <name>A0AAE0P3M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_554316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3M2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="369" mass="42205" checksum="5235D830CBD15E0D" modified="2024-05-29" version="1">MVWISPNFAAPTIPNHEKYEGTEVDANVLKVFPSGTTVKWTSPCGASWWALLSKLDVVLPDGQEKSYFLKIYTVPKADEITLGEFRSSQQLAAIIPRNIPQPVTYGVCAGNPDRAFILSEFRDMTDVMPSTSDFVTLVAKIHQHPSPNRKFGWFRLTTFAGKYVWDNSWCRTWEEYFTRLTKNTMEAEIAIHGPDEELQELSAKILTKVIPRLIRPMETEGRSITPVLLHGDLWHGNVSVDNNTMEPVVYDPCCFYGHNEYDLGMWRASRYLTNQEHVQAYHQLSPPTEPAEDQDDRQALYAMRNDLSTSICWPANKMTRELAKQEMRRLAAKYGDGYEGYIGSKEIANASKIRSPTLELLKNFIWPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4U0</accession>
    <name>A0AAE0P4U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_17723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4U0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36371" checksum="4599A98352EF8BCC" modified="2024-05-29" version="1">MAAITPPNQSSEDLLQPVTRLPNGVYVPMLAFFTPQDEVDVPATQRQAARLMAAGVSGLVIHGSNGEAVHMSRRERRTIIEVVADTVRHETDSHVPVPIIAGCAAMSLRETVELCHESKEAGATHALILPPGYYAGIISKDQIVAYFHSVADQSPLPVLIYNFPAAANGVDLDSDTLLRIAAHPRVVGVKLTCGNTGKLARMVGEVPKVRGGRDDFFVAGGSADFILQGLVVGGHGTISGFANLAPRACVKICELYEDGRLKEARELQHEVAKGDWPAIRYGFVGVKAAMPFFHGAAEASCAVPRLPFTPLDENGPAVREIQQGMSGVLAIETALAAAAAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4Z1</accession>
    <name>A0AAE0P4Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_498570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4Z1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001024">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="452" mass="49087" checksum="3DB1792696FDBFFD" modified="2024-05-29" version="1">MSSARSGTARRIRRKVDFRLCTIAAILCSLNLLDSGVISSAAVTSMPADLGLDQGNRFSIAIFIFTISSIVFQLPATSAVRLVGPRLFFSVSTLLFGIITLCTAFIRGWKTMIASRILLGAAMSGIYPGLTLLISTWYPRKEQQLRFAFMQSGEVIILATGSLVNYFLNRLDNTLGLAGWRWIFLVQGMCTCVISIATYCFRFLTAEEGNVVSLQILKDRGDLYVTRFALRDVLVHARDPKVWAFASLFFMQNIVSTALAYFVPIILQSGLGFSSDSSIILSAPPYYYAVVPVLISSRFADRFQSCAPVITFNALCLITGFAVLGFAGESGAPYFGVFLATGAYVANWAALSAYQANNVVGQWKWVLTAAACAMFNGAGGIAGSFIVRNVEAPLYTTAIWVSIGSHMLMICVVGGLSAHFFRANKAQDKSSVNLEKTGGDSIYAFYIGNERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P564</accession>
    <name>A0AAE0P564_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_554870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P564"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="835" mass="93581" checksum="8F805CD81380C89E" modified="2024-05-29" version="1">MDICPPSSAYDYSRLPSPTCTRLIELQPAVRCNAPIVGKIHIYDLQKDVPPYEALSYTWGASSFPHTLRIQDDASAGGGIVPITQNLLDALLRFRSPVKTRLLWVDAVCINQKDDAEKSTHIPLMTEIYRGAAKVLVWLGGNWPEEEKMLNRYIVLGRRATTTSMPLAQTEWSELFTCALAVVSLSWFSRRWIIQEVVLNANIAMFCGESTELSFLKFAHVLQRLPPTWSSSGTASLVAMYDLWRHWAMGQESMGQCGLLRLIDAFEHFGCMDGRDRIFTLATLAEDITAKTTREGEGGLDPSAHAQQQQWNAEVLVNYANTVEEVYTRTAEMIVNSGHLLWLLGQTAAHAAPNRPHGMPSWVPDWRTPAYRRPFWVGCKDFPRHDADADAEEMWPSRAHADIVNSEPPNLAEKYTLEDDLTIQKHGQIGITSMNVYEQLEAEAKSSIHSVPGTKAHSLHADFWCVEDFSAAVPKYLADTPSYFPCKVNIHKDLGNDDFNHLSYASWYCKVTSSLASKNALTPLSVVWKSKDGYPDTRSSGGSLDQLRWLRDTFSAAYEWAIPPDKQAEEGVWQRFVEKFAYVVTGGGMFIEHLGSEKRQEFRDLANSIDDDDGGDSETRKSTGMYGCDSWKVALIMRRIILGKCPPLPSISDIDPFLKLVTLTMRGRCLFLSNVDWQPTASALEATIVALGVGPPHLQISDRVLSPTQRDRGNASNPRSQFWPRRLWGCTYLVRQAGDSGQVTSRTAGHETDVVMHQGKYSGFFGSSVYCWEFVGDCFLSTSGWISPDSGLHRPRWSCYVDEKYESYVSTYTEIGSGIFDLRNATRGKFSITFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5C3</accession>
    <name>A0AAE0P5C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_516908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5C3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="908" mass="104123" checksum="BB330D52B10BCC02" modified="2024-05-29" version="1">MDADDEDQFTLRGGRGSRYQRPRGSGFLSPLAEDWDVSTGWQQFEEQPSPYRPLVVDGQQQQQQQQQQPPGNRTEGQTPVTPPRTRSPTPQRPSQGTPQGTPATRLNSARNSITSSVFSFFSSKTQGTSRQPDQTQRPEATEQEEMEISDSETEAAPQGEQPQRPQQPQETNEPKPLTLEELRGLYEAAPEDPLRKNKIRIMGIEDSPLRPAPAPATAFFQDWWIGRKILPFWNLFCRVLGIQGKIARGKRGPDELQTGGYWSPTWWQPTQIRFHQERWIRDEEPNEWYEIMYAHLYLRVVNFADAYFEYRDVNDGKIRGAPHSKAARTAWLGVSDSKQFLYYASLVARQDNKDGGWDKILWSRLHRKYLVIGIIAKVLETTVFSDLLFGATKLQKQQLELEDKNLMQLDGYRRTDARASSIKHILQGDTLTREFWPAVDKLAMQLTVMFLPLVRVMDYNFPPSRTKSLRNIQQDLHNIVAEAAYLSIAIRRSRHIFRLSMPLPGQPWDVDQDNVDGQIYAESKAAQNRIDRRAENEWRTERGLPTLEEEEDAAKETESVDAVISPATIIYYAPAIVIAGAFFTYQFRFWVQNSRAFQWISRLLLTIRDALYWAGGRIASLLHLRCAEAPAEQQEEQPPNQQQQQQQQQQQQPEVFATPDTRIGKVSQGVWPGMARHEPLTPPGTGVDNRDHTVGAPDGEVTNRILNEQAAYNVGEVDTPAEFEEEHPRLADHVRVRRGEYFFSDNLWSWMGCLWGLYFSLLLVAFVKKDWLVSTYVRWFNYWASSWALLVWQWVIALLFAVVTVAVRSVVTVVKLIIGGVDWFSGVFVSPVLGWLKRWWSGENAGAEEVAEAAAGWPPKFNWGWVKSLLPEWRDVLVGRVLYQPLGFASDKLARLSEYLARYRNVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Y1</accession>
    <name>A0AAE0P5Y1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H63DRAFT_459404</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Y1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042050511" description="Folylpolyglutamate synthase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3393857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="561" mass="60315" checksum="5159F796AA6007F6" modified="2024-05-29" version="1">MSRCFLAGVLRFRVVLFSPSSSLTSPPPPVQGQGAPRKHYYSTTTAAATTTAANMAAAARTYDDALSRLPQLQSNAATIALFADASAGIPGGAPSLNARAKPETLAWLARAGYKPSDLSAAGLKCVHIAGTKGKGSVTALVAGILSRYPSVAKPVGVYTSPHLVSVRERIVIDGEPISREKFGRYFFELWDRFTEAARAAGDADPEGPNTKPFYFRFLTILAVHVFLREGVRSAVVECGIGGEYDPTTFVLPDDDGASVTAAVVTQLGLDHVSMLGDTVEKIAWNKAGVFKKGVLGVTRRLEERPGVMGVLRDRAREKGCELREVRDEDVEAWKGVDGARLEGPFQRYNMALAVVAARQHLMSLGVKFEGEFGRDGYSLDATPEEFVVGLREASLRGRCETFVNGKGVEWFADGAHTEDSLAGVGEWFAGKIKGDDNVVPVLVFNQQDRDPVVLLTALMAAAQNEVGGGKAVFKHAIFTRNEEKAVNEPDLVVQQKACETLRNLSPDTEATIQTSVQPSVELVRAIAQQAREDGKTCKVLVTGSFHLVGAILKTVDDSVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6I0</accession>
    <name>A0AAE0P6I0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_517427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6I0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000260">
        <property type="entry name" value="Mitochondrial ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="97" mass="10793" checksum="C40CADF2D26E4953" modified="2024-05-29" version="1">MITRFITDVTTKFNPFSANAKSARLFLSFLPPGARASGMNIKTQLLPRTSTEQSALHVKFKDGKEMTLDCENLGIKSIVEEVDRHSRILQKAVDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S2</accession>
    <name>A0AAE0P6S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_43381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="33215" checksum="0E1CA22928EFF6E2" modified="2024-05-29" version="1">MSSSAGGAGAAPPSSSAPQQPNGVPSSSAASNSQTLSGGSSTQQQPPTSSQPATQGTTQSQPGQATQSSTSQTTQPPSQPLANQLLDRQPLGPASPSANAPRPRDARTIELLLTAQGVTAYEQRVPLLLLDFAYRHTSAILSDALHLSADPYTSHAGARPSAASGAAPVNVGDATVTANAIQLAISSRLGFQFRGGGGGGIGPGASAGGTAKDWLMDMAREQNKIALPRISASEWGVRLPSERFVLSGLGWGLRDVWAGQEGADDDSDEDEEFEDVGGLGGAAGGGDRMEGIETEDIGGDGVEGGTVDDIFGDAGMDEDDEDAEMVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P704</accession>
    <name>A0AAE0P704_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_555753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P704"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="397"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="480"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70161" checksum="1CB651BA5EC18834" modified="2024-05-29" version="1">MSHYQRESLHFNHENTHQHLHHHHHRFLHHDHVGDLPVLAVPVVDESVGGDAIFQSTIEHHDFPSAFGARESCAGVAHRAFGSIDPLLVSQSHVLSSELRGDTARSHQQQQHRSHHHRQHQHLQHQEREHLSQKPEAKSKAGPGAAPSSQSDLLNVPAAADPVEKHRSVSVDGSYLTNARGGQFSAKCVENPPDLEEWRQKLFDLGDTVYLDEEEFNTYFPWVDNVYSHRSTQHYKRKPVVTHYWDCRMKGRASGTPKSSDPNKKKRKRQVRERDLCDVKIKITEYKAGAASYILEPQSTDHSVAEVDPTLAAAVTRFQDHLFFSIQRVNGNGTNGIGDGKPSTHKHDLAKSDEIKKCSVQRMLASREKDAKKGQKPSQWKPTGSAAATARMHAQESGIKLYAACFCPFSQRVWIALEAKGLQYQYCETDPFRRPTHLLEANPRGLVPAISEGSFGLGESAVILEYLEEIDSTVLLLPTEYRLRANCRLWIDFINTKIVPSFYSLLAAKDKKSESEGIKGLQRDILRLVQNAEAGGPYFLGDQMSLVDINFAPFALRLSRLLQPYRNWTPPTDESRWKQWIEALENNPHIRSTTSADSLYISTAELLIRSFAHPVIDDTSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P782</accession>
    <name>A0AAE0P782_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_51959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P782"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18010" checksum="7C64B21ED51B4315" modified="2024-05-29" version="1">MASTTPTSSGLVRFTQATAIFLSAAGSGAGLAISSFVIPRLLECPTPLMLQGWKKTFLRGRATMPLSGAIAAASYFFLAYSGRGGRAYAYAGALSVGIIPYTLVLMKSTNNALLDAAEQMEADALLAGGDDKVVVTLEQERSAKYLVDHWGMLNLGRVAMLATASAVALAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7W9</accession>
    <name>A0AAE0P7W9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_556081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7W9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="278" mass="31293" checksum="39A054688538BE2A" modified="2024-05-29" version="1">MLRLQRSAQSNDWSGMELVRAYPKARRAKKLMEDVLKQLKIFATLHAFETATRTQVEGIDRAIEELSKPDSMKSSDTTTVSQNIASGGKDEFRKLIVRLHDCGLLNFFEDVPLVSTKTSTGKIKDTKISKFDVWDEAKTGVRYTLHPVIREWLRARQQPLGLESMTTDPTSDATAALATFAKGVRLKNMTLQTRIDVSIHIEHLSNNRSDIFNEPLKPDAEDTEMAPAFLFFKFCYSFDGNRTARDLLKSLLLARTKKGVPQLSSGTVLIALQLCQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8J0</accession>
    <name>A0AAE0P8J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_506779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8J0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933451" evidence="2">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="243" mass="26780" checksum="8E542F5147A8223D" modified="2024-05-29" version="1">MPAPAKHWFFMALAFTVLQPILDITAGGYQYQDVGIPTVYKSGNLTMVNMLHNLLEIPLQFTITGVQYANYTFAQKALAATPGMSTAFALPEEMATRAIAGSSSQRLVIQTWTGALFISNTTALFMLVVFGIWQILRLPEPVPIMSGITEIDMLNLARRIEVHKLARFKGNSGEQEHLILAEFTGVINAASSLDIVRKLREVRVLHRKLVTGGEETWPPFAGTLSLATRTVIKTVALLNKPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW00</accession>
    <name>A0AAE0TW00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_546141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW00"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="283" mass="32289" checksum="076AA79BFC00585B" modified="2024-05-29" version="1" fragment="single">GKSASLTLQLFISLVRSLEDTRHSLHFCNHRTSAITALLQSPHFCNHRTSAITALLQSPHFCTHYAPQGVYTNDDTRQPTSLTGVHLCIKHIHPSRSTYLAPPPHTAYQFNKNVKAAMNFLMQEEKQALLSLGINMAVQAAMSPAAMNREQKQALLQYGINMAENQLRLRALRYMAAKNRSSPKGSAFLPPVWYRRSRETHWRPMAYIKDWVTGRVRPRTKIDDMVDAMSRERRARWIEERGRDLDDDGDDDDDDEDEVGDEESEESTEEDGDEDSEDDDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZF2</accession>
    <name>A0AAE0TZF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_543331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZF2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="643" mass="70137" checksum="4CE091B175C021B4" modified="2024-05-29" version="1">MAKINFDDLTVGSIEATIHPSQIIIPSIMSNWAKKQEERGRSTLGVTFSLKDPSKSTWSTAGPSLCSIHPYKDPVHEAKMREIETQSPLQADTSLNCLLHCEMVDNHEKPKNLTLNHHGNSVTRGTTLTDSDDQIDASDIYVHPVSWLKDTGGSGNHTVDGQHSVGLDPENHSSDASVYNAKRYPSAHVEDKCVAYYEFNKTNMKECADHVFDATSHHKHLHRSDASVKVIWESGGNKFHMAGKAICIYDSTWCHTSNFNDEGQACERLMHNISWNFDIILADADNGVLNIIVDKTYKGSNIASLQIVPNKEVQTGVTTPSNQDNEIGAEFQQKLQFVYPGNGTLRFLNPCINRHGNVLAELEYLPYASKGREVIQAPAPHQAALPQIAMPVENPVTVSSGVCAPRQKMTWSTVQTNPAASVLKEMTTAEIKIIAENKTQSYQYFGAFSVTFKSGKGPGNLFNAAQIHGVGAETKGAAQIEPGAESTKKDEETEPHYTVDIETSSGVDNVDRRLGLAQVAQIANSGVILWQATIKAAMNEAIIVPPGGYIALKFYIRTGGEGTYELTVYESFGDENDPTEPPVDAPNPEARAEEAAKKEAAEKAAAEKEKREAAESEGWTLAGYKPSGTSKPVNRNTDDSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZK2</accession>
    <name>A0AAE0TZK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_510121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZK2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="729" mass="82224" checksum="40EDDA0A26C12096" modified="2024-05-29" version="1">MDSVMHAPEEPAGVVAGMSHNIDLGTRQSLVNQLYFDKIDERLTNLKPAQSQTCSWFFDKPEYASWHDASRQEEHGGFLWIKGNPGTGKSTLMKFLFENAKSNPRGGPEQITLSFFFLARGTIEERSTKGLYRSLLHQLFSKCEDLIDSLEWLTADGAKLVERNGWDEEALKRTFLDAVQRLGSRPLMIFVDALDECNKEEAADMVYFFENLCDEAKAAHVRLQTCFSVRHYPTITIETGIELTLEHEPGHTRDIQRYMNSRLRRLGKASQTETLRSQILAKSANIFLWVVLVVDILIREYPNNSVSIRKMLERLKSISPGLKDLFDMILTRDNDHLTQLELCLKWILFATRPLKPEELYFAVQFGYDSTCTGVWDHDDVTLDAMKTFARSASKGLAEVTRNKAAEVQFIHESVLSSQTNEPSPKESATVDSREAVISMSPFLEYSIHHILSHANAAQGGEKNLDHLIRIYPEQRRFFTLTKGEDRYGMPIFAALAMGSDKALKAFADITLAHLEAHTAESMLGAVLENFPAHLMIGRMFSFPRSKPLSQVVAEQDEEALFALLIAAGELSWLDNYLPSGDVLCLAAQRGFEVVVQHAVDMGADLESTFRGQTALQLALERGHDSVTKYLLEHGAKTEPDTPRMPSPLQIAIKSRNDRNVRILLDRGATIDPFCPPILIKEYFVKAVRQGDESMVLAMLDRGADINIRDPFSGVTARKRRQYRTGAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZT2</accession>
    <name>A0AAE0TZT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZT2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="105" mass="11572" checksum="5F137479A6848E4E" modified="2024-05-29" version="1">MASPKVLAMTSQLVRDTTQSRKRTDDLLYVAGITARRMPKLQAFALWKGIKGEACAFIYHRDGGGASITWRGTWDMQLSPRVLVQALAQANRVKWRALAALALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZU3</accession>
    <name>A0AAE0TZU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_543833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="362"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117614" checksum="342AA7640B705B02" modified="2024-05-29" version="1">MDELNAKRRLKYANLTPMAERIKAGNERKAEAEAKADALAGTAKTESKTEPLPEVAEAEPKTEPSSGTTEAEPKTEPEPSAERKEEQDQKPRENEMSDENKALIRVWMESEDDGQPDDADRLGDYDAEFEETSKNFNRYIHHHFQGKEWGTYSEKKDQKDRIDEEWFIPSPAVLDETDPEYLCEMCRHIDFGALLTQRGLPGTNQPGTNTVIQLQALPRVLDAEVAGNCAFCGLVRQAFKDRCTPEEIQATRNHDDKFESMRLTVLDDGPDYALRLEIMLADLPKRVVVQMMMPPHPKASLPLQGAPVRQDKADMERLGTWIQNCETNHRGKPAVSISELDNLRVIDVGDGCIVTVTAPCRYACLSYVWGQELGTRLTFDTRAILEKPGALSDESMNLGQTLRDAIEVTRAIGLRYLWIDALCIIQDDDDDKAANIAQMGAIYSNAVVNIIASTNSRPAQGLPGVADTPRSHAQVVRRLQGIALAAAFHDPRLPYHDIEASVWNSRAWTFQERHLSQRAVYFTSCQMHFTCPHESVFEDTVPGLSAEHRPKPLADASRFDSRVMALMHHIWEDPTQTMFGNKTFHIHGRGSRAVSLMGEDQALPSPIYRAVPVPSHGDGGILRLEGETLWKAYSDAVAMYTQREMTWQSDVLNAFQGVTDLLAQGVNTEFWHGLPEFAFDQALLWYPREPLKRRGHDGAPPSWSWAGWQGHTTYRGRGWYNAVALPPVNVVRWLRLVQPWELVQEYVGSEENPTREQIVEHAQRVAHGPKILRVIGTSTLYHLDDVENDGWTHRRDADRNEHYYTHAAYPGLRFTYPATLPSQPILRRVSPLGNLFFEARTVPARFVDMSTTPHTADPGVDDFLQLGLNDASRSFRQSRRPWEHIIYHQGYRAGYLSLHAPLTSPKGNYILVAMSRDSLPDIAPPLGGWDAYWGLEPRDAQQEVFFRWEWGPEERRMPAFGPFRQDEPSARAVSENGDPHWEAVRFGGPAMLSVYNVLLLERKRDGDDEGGQWWCERVGLGKVNACAFGHAKPTEELILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0C8</accession>
    <name>A0AAE0U0C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS monocarboxylate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_494704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0C8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="37104" checksum="FEBD48B48711D6A7" modified="2024-05-29" version="1">MINGFGMVASYGIFLPHWQKVLNRPASDVSWVGSLQLCMPFAVSSFSGRVMDAGYFRPILVVGCGLHIFGIFCTASLSQYWQLDITLALGVASCGAPVGGVIFPVLQDKLDYSWVIRIMGFVVLFNTILILLIARPKKLHRPRAPLVDLQAWKEPAYTLFAIGLFTICPGLFFPYFYMPKYGGEVIGLPSSTSLTMLLILNSVGIPARLIPTFVAHYFFGAFSVLIPFSFCTGIMNFVWLIITEPSSFISFSVVFGVVANAVLTTDLTKMGTRIGMIMTFASLACLIGPPISGFLIARGKGSFRYAQIFAGTTVLAGTAIMCVSRWLQIWGVMKWEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0Z1</accession>
    <name>A0AAE0U0Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_467986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0Z1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="10"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="413" mass="44308" checksum="B85B3BCBA16656B1" modified="2024-05-29" version="1">MSTSTSTPDFEALLQKAVDDGAVAGVVAIAQNKAGTLNYSTAIGHASLGTNPPTPMQLNTIFTLASQTKLLTSLCVLQLIDRGLITLETDVTLHLPALAAKQILTGFSSDGLTPLFTPRTKPILLRHLLTHSSGLGYSFLHPDLLKWHTITKPGAAPPPAGGPFDTVEARFDMPLLFEPGTNWQYGSSIDWAGKLVEVLTGLDLETYLTTNVLNPVGVTPGTISFHLERHPSLLARQAGMNARDPSTGRLVHAAGFAWPTGLPTDRACFGGEGAFADLSEYMKILVSLLNDDEKILSKQTAAALFSPQLKDKDPAAKAALVKNLEHPEWIVGYVPTDTNGEYDWGLGGLLVDGDSHVYRKSGFLIWGGVFNTTWFIDRKAGVCGTFGTQTLTPADPLVNPLMKAFEEAVYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U160</accession>
    <name>A0AAE0U160_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_540856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U160"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="658" mass="72574" checksum="036037C753BF99BF" modified="2024-05-29" version="1">METTFDKPAQAGKDDVPLLLPLRQIRGEIDKTGDEHAWPRLGRSPFVRSRVQSIGIWNTVLLSAGFLVSAAVSLFLGFLWLSSPNCDPSHRFCGLWRNIVLSNNVLSTAITISATVLRRALALQTGVALSMVAALALESAAGVPLLGYIWSTFRSMPLYNVCALAVIWKTLASRITSTLLVSNLGPGYVVGNPIKADRYIGKDAEGLTDFLRRLFDHTPQYWFGGGQVAYPLFAESARFPAPENNIWKRDTSPTLRAFPPVLAFDEKRVLESFLGYSAIWDTTFSCFEKSPFQYLIINTTGDWIHWSMGLKSESSLKKAEDGLNWELVEEWPWTTATTPITYNLPPEMNDPSPFTATIGISMSYCVTPFASTVVPVSMRRGRNRAEPVTEPTYGNRTQDSVNLNEIARLYAGAWSGEAHFSRGVFKLERIPMTGPFKWDAPDELQLITYELSSLVIQEIHEGALVAINGLNPSTSLCDQCHLDASTTFRAHRDHLAVSQHILRSTGSLPLTMQTVWTILAQIAYYDRLPEFNVQRESSIASFSQVLVPGGVSGLVFVVIVIVGQNLAVALIMSLFIRRTRLSGNLWQGLGQLVASDIGEVASRTTVATDEEVLAHLLGNGELGGTSVSLVCDVQEKVSRVRQMDRDQPSSELQTLNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1D7</accession>
    <name>A0AAE0U1D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_393029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="45"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="386"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="570"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="512"/>
            <end position="513"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3386979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="792" mass="89448" checksum="EDB354A831172ABA" modified="2024-05-29" version="1">MASDRTLNPESDSYESRPVFYIGQHDSNRSVTLSDYQYGHVLDCGFGFVTTPITNHHFFQRVVDLYKGYLIEREEWALGRLTASQLANSSLPGPVVPTLTDKDTTYFPSNYVGSLVAYASPWIDLCSLNPHISSISRQVLNLEVAYANFCGARSIIVPGPRDDESRGVAQYARAIQEALQVAGRANLIIHMPMYREPNLEEKAETLSSLFTRTNGAKVDAPAVIDLFSAWDSWHTVRSVCTYASRLFVALRMPKRMPEKDLQQRWFAEPLHYLSIRKAVFQLNRSGHPTLNKSHQELINHYMRLKNAPWLILCDVGPDVEAVEASKPVELSADKMAVDFPSLDEAKKVLKENRGSRLPPLNTYVSYLKYLERQQAPYSILETPTLVNFQDWLQSPLQPLSDNLESATYEMFEGDPVKYDQYELAIQEAMAEWKVLKKPTSSVVSKDSDSPELIVAVAGAGRGPLVTRVLRAAKTTNTRIQLWALEKNQNAYVYLLRQNQREWDNQVTVVKTDMRGWEGPRPKGYTNIITTVDILVTELLGSFGDNELSPECLDGIQRHIARPHGISIPQSYTAHLSPISTPRIFADISSRSDVDPNAFETPWVVRLFAMDFVSQKVPGHGRFQQAWEFIHPVEVSRADDFSAEHGADNKYAIIGGGNMSGSSGTNDHNARHCHLTFVCPTRGVIHGLAGFFESVLYAPQTADKEPVEISILPDQIDRKSKDMISWFPIFFPLKTPLYFPTDTELEVSMWRQTDDTKVWYEWMVEVFAWAGPKTRIKVGATEMHSSRKIACLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3B9</accession>
    <name>A0AAE0U3B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_99197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3B9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="842" mass="92284" checksum="78434FDA933A8C56" modified="2024-05-29" version="1">MEMVLDMEVDQDADVDTAASTTSAGTGNGTSTGGPGSATSTTTKLAEPRRRNRPALSCIQCRTRKIRCDRNEPCASCLKSKIVNCTYEEARRPKPRLWRLSPAPAPGSAPSDISPPAEDVFSRVGLGHAPTSGSVPGPPPGSGFTFREVQPLGSLSGLQYATSAASLPSVRSSDSASIPSPASRQLDSTPGVSTPSSTTPALADRVRQLEQQLADALKRPSHASQYPQQPHPSAVPSLSKTRYFGSSHWVNGTKPFPLLISIGAQIDRDKNSEVYFLLQKCKSLGKSIKAQRVPAQVGFDVGRTIPTESIARRLVDAYFRTIEGVYRILHVPTFWQEYRRYWQSPESASKGFVVQFQLCMAIGTCFQDDVTSLRHSAIQWVYEAQAWFVSPSEKSRMNLAGLQTMCLLHLAREACGVSGDLVWISAGALMRTAMHMGLHRDPDSFSGMSTFRSEMRRRLWATILEIALQSSLDSGGPPLVALADFDTHAPSNFDDDQLADDENFSSVPRPLSTFTQTTVQLALLRSFPTRLAIAQYVNHFNSPVTYEETLKWNSELTSACRALSATLQPSYDPAGVLPKRLSLFQLRLAEHMVHRFFMALNHPWLCSAQHNPAYYFARKMCVETSLKLYRAFATGSPAGDSGTASPTDDFTRLATCGHGAFRSVPTLAVLTICLELLWQVQEDRSFRQSMIMDHQLDKQGPGSETDVGASGGIGSGAAPRQDLFEALRYSIGWAERRIQNGETNIKGYLMWSALLTQIQAVQRGASDAEVERIVMNSIIDELRKCWHLLKDSTGMSTPPGLNSGFDDLRLGFGNEWASEDLAQMQGFSSLFNFDDGGFFVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U507</accession>
    <name>A0AAE0U507_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_430150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U507"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3391298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="525" mass="59108" checksum="4FE370C32C34B784" modified="2024-05-29" version="1">MGIAAKADGTRSVPTKGLAAAAFTLVTTHWLLVLVSLFVSRALYKRYASPLRKYPGPFLASFSRLWMFWSTWSGQTHLDHIALHKKYGPIVRITPNELSLASPEAARTLLSAGKRFFKTPFYGVFPPPENPDIFTETREDVHAQKKRVANVPYSMAAMQQLSPFIDDTIDVLMRKINEHIEANAGVFDLGDYLHYFAFDVLGEVAFSRNFGFLREGRDVDNAIKTIDKSQTYNGIVGQIPELDKVLRRNPLWQFVPWLSTKNALITRMALEEMDQRRPFVKDSAGLLRSGDGRQDLMSSLIVGHLKDPQRFREGDVFAVAHGAIFAGSDSTASTMQSFFWHTLASSPAYKNITREIEQAVETGVIPAEGNITWNQSQNLPYFQACLKEAMRVRPAVGLNISRLVPPEGATLDGIFFPGGTSLAVNGWVLHLDKDVFGQDSDVFRPERWLEDEEKSKRMERYMFQFGGGSHLCIGRNLALLEINKVVPRLLRDYRFELVHPDKPLTANASFFVVQSGLEVYVRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6Z3</accession>
    <name>A0AAE0U6Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_516374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6Z3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="49879" checksum="55B4453413E46DF8" modified="2024-05-29" version="1">MQAEDQELMARISQVAGQINRHKNQQAGLVPTHAARPHHRTFNEVPRSAHARVDGFGDAGHSNGWHRGGHPYRGHYNTRNPPLHRHRTLVLNGGTSQQSKPNDAESGAASDISNSSSWVTKTDRHLQLINSSVYEKETQARTRAIEQTRRQKQVLKDERERTKLINHLNRMANSGGAAPAGHRTPSAKYEIAVQGIRFVVAKNGSKLVKVPGDVNSAKATPKMAIVGGVRFYRSKNGNLYRHGIIKAQQQSGSVKKLGVPCKMFSMTGSCTLGPRCRYTHDPEKVAACKDFLQQGECLNGDACDLSHDLTPKRTPTCLHFVKDNCTKSSCRYTHVKVSPAAPVCRAFGLYGYCEKGASCPDRHAFECPDFSNTGVCKSKGCKLPHRERASVLRKANAKDMNAGDEEMADISSDEDGESVDSNDVDSDEVDEFIGQDDETGGLDFSEQRDFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U709</accession>
    <name>A0AAE0U709_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_14021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U709"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="984" mass="105342" checksum="C6CE16305DC83D5C" modified="2024-05-29" version="1">MDGASLDPRLRDASAKAARAVSPRTAATAGAAGSNGARGGGGPLKSQQSQQPIAIAAQPPSHRLQPQSQHSQAPQTQAQSQSQSQSPTQAQAFAFPQTPSSTAPTPAPDGNHNSAASGGAMTPPAADDTPGDAKKPRSCESCRGLKVRCEFDPANSEGSCRRCAKAGRACVVTQPTRKRQKKTDSRVAELEKKIDALTASLQATRGSAGATPLSTTATPTASAKVAETRTSSVAAAVTSPTLGRKDSSAASAANRGNGYYAPSSGASRDWPPQAPPPERPAPALQQPSSHITPPYSSVDLEAGRYPTLASVAGKKRKINDVRELAEELRGAAMTAPPLPADDRPEERSDIIEKGIMTMALANQLFARYTEQMVPHLPGVVFPPETTAAELRASRPILFLAVMTAASNEMPAMQRVLTKELMTVIAEKAIVVGEKRLEIVQALQVAVIWYWPPEKFEELKFYQLVHMAAVMAIDIGLGRKKQARGGFRKHIPTSWRDHPLRKNPPPDPTTLEARRAWLTCFFLAASTSMALHRPNLIRWTPFMGECVDVLESSPDAAPTDKYLCHLVWTHRLAEEVGVSFSMDDPSSTPNIADSRTQYALKGFERQLEKYSSSIPPELQQPTLKLGFHVLSLYMHEIATHNEFSDDCRPPLGPHTAEHLREALVSDIPLTPAHINALSACLTAIDGIFETFLSMDVQKIRCLPIFNLVRVAYATVVLIKVYFAASSPKGELGKVINKDNMKVEQHLEHLLEKFRATAADEKSRPASKFLIVLVMLRSWFLSQKQAQSGGGPGVRETSSCSRRSSTVAVGEKDTPAREQPDYNTPLQLLSEVATGANSGSANASAPANPVLRPNNADLIPNGSWYNKLPTPFVGYTAPDGGNLSQGTLAAAAGLGDHATNTPWMDTAFSADFDYSFLGDGFAQVMDWTLGGAFGDTNGGGMQSGGSMEEGGVRYVMQEPPWFQMGMGTALDGLGDGGVGQMGGFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7Z6</accession>
    <name>A0AAE0U7Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_555240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="307"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="109597" checksum="AC821E736B038975" modified="2024-05-29" version="1">MADSVGIVKFHPKQEPKLHITKTDIVFVHGLGGHFSKTWQAKDWTVWPRDLLPILKDIHNVRVLSFDYNSSIKGSTAMTSNRAKQLLVFLEHERQDLHARARPVVFVGHSLGGVIIKQAIRLASPGLLGGSEHPSLGLATLGVMFFATPHGKIDEEVWKKFCCEVLRLNKPNEHATPTTGMLKQVIKNTAELAEITEEFCYLEKQLGLVSFIEEDEIREVKSLLVRQDTSLLAPGQRLAKRLPGDHLQMCKFNWKDKDAFEQSVGKWMKWIIDKSPRSGAHRHRQALNSLCQDIFHQYFLSKEATPGTCGWITKRLEDWIKPSKPKKPRQWIHGPPGCGKSYAAKHLITSLHMHGPKFQVVHCFLKDSSSARNNVRALLRATVHLALTLKPDLIEELVVPVFQDEQKLEAWSMDELRALWPKVMARLAQQGPLFVIVDGFDEIGKECRDEFLKCIRELEHIIGATGDMRLLLLSREYEGIDIQSIKFGFDRHGVSHADTKTDIEKSIMAGLETIRQARAVRNMPKYSEAVRTRLKGKILEHAKGSYLWAAMAVERLSRTLPEASRLEDIYTNLLPKRLAGLCDEILEAAQKNPEAAPFIRHVLLWLTFQRRGLNAAELNIAQALGCARDKYLGHEEMNNQKLGKHLVDDLETEVDWWCGEFVKRTDNGHFEIIHREVKEYLTTRADQLLSIVGDGTTNHHHHHHRSEHYTKPRVHAALGSLCATYLAMPYFRDSGVPGIQDETEVNRGDIWETKVRKRILENSFVSYAALNWSEHLREAGHKCLLEVSTDLDLRHLVLLEDKATHYAISWTEVWWFYQTWPRMRYSTDAIGPMVVHKGSESTADEQTTNSGHHLRAEKPAVTMTLKTQPTDAIIKTPSKPEKRPTKAFKQPTSQAQSATQASDTTIASTTIASTTIASTTIASTTNARTTIASTTIAGTTIASSTNSATRNTQPHTPNQNDIGTARGTRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Q9</accession>
    <name>A0AAE0U8Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_55540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Q9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="596"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="79801" checksum="329921F65EF893F3" modified="2024-05-29" version="1">MVSDETYEICLPILQDSSLEDEEKTDKLEEVLKEKTSLTGQSLENAILDAMWRYRDGGGNATSPPPIRQTILRRPSPASWRGSGTPLSGSPRLGVSPLAPPGFVPTNFGRAKSSTAPSPFGSPRPSPRLAFAAPVPHSPSLNAYQFANDDAPSQEVFGNYQSDIVDWLVSDDAISVASSIGGSSGLNVAAPEFAPSQQNDMTPYDMLRSILGQSKSDEEIGAALAMHGYDLGATVAAIMDTQMQDNLALAAQAEEARVVVIGKSMTPDARPTTPADQQRSGVICKFYLSTGQCLRSDCRFSHDLSSHICKYWVAGSCLAGPTCIFSHDPAHLVNRLHIDGSSTPPTQQATVNVQDYNSFPSLQPATPEQLPVFAASSSYPSVGITPPPGFKGHHGYPGDRPRSRPSSRHQQKETMQAAPSPDDADAFPSLGSASAKQGKKHHGKRGGHGHGHKENFAPSTLADIVKMSPSPTLGAVRPDRKLSRNGSSTSIRNGENSAAAQAIPNPKHIPWLETGDKANKAYLKARQEAIKHGGLRNKFLQSAAQAWNRNDARAAKALSLRGQSENDLMRKAHREAANQLYEERNKDRTNCPEIYVDLHGLHPDEAVEYLEGVLMENVSENRPIYAITGTGHHSKNGKDKVGKALRVFLNEWRYAYREFSVPGDRNSMGGILGIDARSWDKSLSRDGLTLARKDDEGKEEVDILAQGVEIGEGKVKLLVRDPSVLKEPPKGPSGNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K092</accession>
    <name>A0AAE0K092_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_84563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K092"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="217"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="376" mass="41621" checksum="D56C2072B16CD085" modified="2024-05-29" version="1">MAQTAPTTELRLMSGNGLISRTILDTPLRDAAPSEVPIIDVSGMFSAAKADRQAVADKIRAAATNNGFFYLANHGISTDVTDAAHSAALDFFHQPTDLKEVANTKLASANKYMSGWKPPASMHINPSESVDQRESFSWRYDPTYDPSLPQGEPLPPKVAAVLPIDANGFPWSATTDSCPQFKQSVIPCYQAVLNLGRALLRSFALSLDLAEDAFDAKFTHPDASMAINFYPSLPSPPAVDDKVTRVSIGSHTDFQLFTILWQDAVGGLQVLSRSGEWLRAQPVRGTFVVNFGDYMQRITNDQFPSTVHRVQNRSGRERLSMAFFFGFNLDESCAVLDTCVGEGEEKRYKEISCNDWTQRRLRAMQVKIEDKVEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0L8</accession>
    <name>A0AAE0K0L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_370842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0L8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="247"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="473" mass="53613" checksum="C22CEA3FD53724CB" modified="2024-05-29" version="1" fragment="single">MWLINTRTLALELVVDPKDQEYAILSHTWGDGEVTFHDMENLTAARSKPSFGKIKTTCALALDCGYQYAWVDTCCINKESSAELSEAINSMFQWYRDAAVCFAFLADLDTGTAATVPDQLKEVRDSFGASYDMPVPPAPTVPDNLGHCRWFTRGWTLQELIAPSDVEFYDCNWCFIGTKQSLMEELSAITWIDINVLEDVEALPTVPIARRMSWAARRQTTRQEDMAYCLLGIFDVNMPMIYGEGPKAFLRLQEEIVKENNDLSLFAWCSEREEENGDDGGTDSSIEKFRGLLARSPKEFARCRHLERSRAHSSAQEGEFVLTNSGFRLNTHLAMSQLCEYILNVNCLYRVTKEDDQVSTPSLGIPLTKTPSGFVRVRPHTRLLTLDPTAWVGRTTPVYIHKHLTRAESTCTVFPGTEQSFAFVFETGSRRWAWQSDDAIARPAALWDDFQQLFMTAQDTRFTGIVEFSLTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0P0</accession>
    <name>A0AAE0K0P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_535462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0P0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3367505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="653" mass="72362" checksum="34E23498B13E1F2C" modified="2024-05-29" version="1">MTPSLGALPQEMLDAIGKYLDHLDLARLLSCSRLFQWMVEPVLYRDRDAQVRAMRWACRRGNLHTLRLAISYGARVSTIGGVGLAIGNEFVSLLRLGTMGHEVIPVWNPSPLRLKRIDGVWQTLAVAAKNIDAFQVLMESGASLVAPQTCRHVFNGQVKSMLNNLCSRSSNWPLFRSLYEKGFDEEIRKAGQGVDVALPLFQLIKAKAPSDLIHVILDRGADPNRVWTYKHQEIISPLSAAILANSERIFRLLLEQGANIHGKDARTLVKTGLHIPVFAAAQTMAVADHGTAMMQLCLDSGADLNQLAPVVEDHWDYFYTTPFLIFLQSVKSWRKRRRGSTARRHNDTLDKMTWLLEHGALPNIVAAAAQTDADADHPVFDKASTRWATWNRLNCVETPIAIEFLLDNYGGFQLENLRGDGLLPAAIKLIVQHGGARGHTASLLHFYDVPSSDNIHCLGPSPPPPPTGPSRTAGREVLRNILLEEKGPHAEDVSTVLSNFLIWQCFRISNEEYRRTAFATMDQLIAAGADINHQICGWSGPTALHQICRELGGSQGRRRTTISDRGARNEHAFLYFLQSRGADPTLLFEGKTALEILLENAETQEPVVRAHLECLAETLRGRGDCCIPCGEEGCVLKGCCGKKLCGKHHPEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0U0</accession>
    <name>A0AAE0K0U0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_83802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0U0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000013">
        <property type="entry name" value="Probable exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249151" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="677"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3367580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="770" mass="83542" checksum="F25C4141F0C70C3F" modified="2024-05-29" version="1">MVLLSSFLVASATATMASAQGSLGTPFPNCASGLLAKNQVCNVTLSPPERAAALVAALTNDEKLQNIISKSKGASRIGLPAYNWWSEALHGVAYAPGTQFRKGQGEFNSSTSFPMPLLMAASFDDNLMEQIGEVIGIEGRAFGNGRYSGIDYWTPNVNPFKDPRWGRGSETPGEDVLRVKRYAKYMVKGLEGPGPERRVVATCKHYAANDFEDWNGATRHNFNAKVSLQDLAEYYLMPFQQCARDSRVGSIMCAYNAVNGVPSCANTYLMQTILREHWNWTDHSNYITSDCEAVQDVSLNHKYAKSNAEGTAMCFNAGMDTSCEYDSSSDIPGAWRQGLLKAGVVDQALKRLYEGLIRTGYFDGNTSTYANLGWDDVNKPKSQELSLQSAVGGMVLLKNDGALPLRLSKASKLAMIGFWADDAGDKLSGGYSGTPAYTHTPAWAARQLGYTIKTATGPVLEKGSASKWLASALTAARDADYILYFGGLDTSAAGETKDRMTIDWPTAQLDLLKQLGQLNKPIIVIQLGDQLDDTPLFDSANINAVLWANWPGQDGGPAVMQLLTGAKSPAGRLPVTQYPANYTSLVAMTDMSLRPSSGAKASPGRTYRWYPTPIRPFGFGLHYTTFTPTILNSSLTSDITLTTTNILAGCTSSHLDTCPLPPLPVSVRNTGNATSDYVVLAFIAGEHGPKPYPIKTLAAYTRLKDIKPGEQRDAKLEWTVGDIARHDEQGNTVLYPGTYEVLIDQPTRTAQRFVVSGPEMVLDKWPAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K151</accession>
    <name>A0AAE0K151_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hypoxia induced protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_529175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K151"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="12">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3367456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="221" mass="24373" checksum="128ADF91622AE34B" modified="2024-05-29" version="1">MSDRPMPSSFDGNPEFNKESGLQKITKKLKKEPLIPFGCLLTVAAFASAYRAMRRGDHNQVQKMFRARVAAQAFTVVCIVGGGLYYAEDRNKTKEIWKAQALKEEEEKRDKWIKELEARDAEDKALKERLDRRRQKAADRGSASAVTEAVAAQARAAFKSDKDARDVAEIEVRDQAASVEEKEGSGVLDTLGGWIGGSKKAPGDKPLAQEGAKDDADLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1C3</accession>
    <name>A0AAE0K1C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellobiose dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_73054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1C3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1210:FF:000004">
        <property type="entry name" value="Cellobiose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042031175" evidence="6">
        <location>
            <begin position="25"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="798"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3368229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="834" mass="88366" checksum="8340F3C2C4ECD0CA" modified="2024-05-29" version="1">MRSTSSQLLRVLATAGSFLPSVIAQASAAVKYTDPATGIIFDTWGIANGGSQTQGGITFGVALPSDGLSNDASEFIGILTCSSKDTINTGWCGLSLGGPMTNSLLLTAWPKGNTIYTSFRYATGYAMPDVYTGDAKLTQISSTVNATHYSLIYRCQNCLKWNQGGQAGGASTSAGYMVLGWVQAFPAPGNPTCPSQITLAQHDNGMGIFGAVLDSNAANPSYTAWAAKATKTVTETCAGPTETAVASVPVPTDLAFDYIIVGGGAGGIPLADKLSESGKSVLLIEKGPASTSRHGGTLKPDWLVGTNLTRFDVPGLCNQIWVDSAGIACTDTDQMAGCVLGGGTAINAGLWFKPYALDWDYLFPTGWKSADLQAATNRVFSRIPGTDTPSTDGKRYIQQGFDVLSRGLKAGGWSQVTPNTVPNQKNRTFANTPYMYSGGERGGPLATYLVTAKGRSNFKLWLNTSVRRAVRDGGHVTGLEVEAFRDGGYKGTINLTKLTGRVILSAGTFGSAKILLRSGIGPKDQLDIVKASTIDGPTMIGNDSWINLPVGYNLDDHLNTDTVITHPDVAFYDFYAAWTNPNVTDKTNYLNRRTGILAQAAPNIGPMFWEEIKGVDNIIRQLQWTARVEGSFDTPNGHAMTMSQYLGRGATSRGRMTITPNLGTIVSDVPYLKDANDKAAVIQGIINVQNALKGVSGLVWQYPNSSTSAADYVNNMVVSYSNRRSNHWTGTAKIGTDDGRINSGSAVVDTNTRVYGTDNLFVVDASIFPGVPTTNPSSYIVVAAEAASQKILALPANAAVAKYGQCGGRNWSGSFVCAAGSTCKFTNEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1L8</accession>
    <name>A0AAE0K1L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_536081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1L8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041997143" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="363" mass="39146" checksum="15B1110724D1181B" modified="2024-05-29" version="1">MVRLTTNVVALAALLAHDATAQTGSARGSDFLRFGCSQLVVERTDPLVNPGMAPTPHMHQIVGGSSFNITMDPLTIDPPATSKCTSCKMTEDFSNYWTASIYFRSPENGTFKRVPQMANGRLNGTLLEQDGGLTIYYMRPFSGSNKKVTVMKPGFRMLTGDPTLRTKSSGPSAICHRCLSKSERIMGGNGAPCDSSDTAAFPSKPCPGGIRATVIFPSCWDGKNLDSPDHKSHVAYAPGSAALAGDKCPASHPVRIPQVMYEIMYDTSSFADPAYYKGGKQPLVYSTGDPTGYGAHGDYLFGWKDGALQRAMDALGTNCFSETCPVLKMQSGEDLIKCTKQQQVREEIGNTWLKEIPGAPMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1Z6</accession>
    <name>A0AAE0K1Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_68900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="222" mass="25015" checksum="3494CF1C230C0B20" modified="2024-05-29" version="1">MASSQLQAAPATDIDELATLWQAALDNYAADTGAQIQKYNKPVRDLDGIISWVRGEKVKFADFRNHGSYKLVRYRKWVKECLEGLTRVSKTVGHAAKLSFPPAEAICSAFDRLRPDYDTTVSFWRGFDSYLVELGLSPVQALRVPELQIVISKIFAEILLLSKTWTKHMKWGPTWGANQESSEMLCFTGSGSAFVVRGFQLPRHSRQSQYSQLCDSTVSMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5Q5</accession>
    <name>A0AAE0K5Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_303394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="280"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3369830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="475" mass="54039" checksum="9C50DAC176342BB4" modified="2024-05-29" version="1">MSATDADDALHAVIPSSLTEKSPKKNKRDKKEHKKRPRDDDELAVVAETPLRKQKRAKNENPTNEDANSEPEQPDLSERRKKKKQHKHRGDSDDELEADEAAEAKAARKKSKKRRKHRDEDQKDGMDFDAPEDEEAHSKRKSKDRKKDKKKRHFSPPPTADADDRMEVDAPTAASTTLPIDPSFPFFTQAISLYLPFFPVGFDKPLTNIAAQHLDPLLNHYSPVLRGVLLSYSNLNLSDRPTKASRLHPPTDETPALLHSFNEYAVGFGWLTFDAHLFVPARGKWMEGVLQLQSEGYIGVVCWNKFNASVEAKRLPKGWRWIDLEKSNGDLPTPDWDNEPVQEERSSEDALDGEELQVVEQMHTTGYWVNESGRKVSGKLRFRIKNFDVGLAGDYGYLSLEGTFLDDDAERALVAEEREQDKKRRSRQNPTGGLRPLSRRVPEFSMTKFGKEEEEEDSGQRTIVYKGSRPGTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8Q3</accession>
    <name>A0AAE0K8Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_401336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8Q3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042179953" evidence="5">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3371974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="400" mass="44106" checksum="D7D99D54184F2F67" modified="2024-05-29" version="1">MRNLSLFVRLALWLSAAVVVTGSPKPPVSKALFDVPRGKTAQVSIIDSTMRFDGIPVSFFMGPPLPGFDMMGALTTWCFLVESSKGEKVLFDIGVPKDFTTYSPFVQEQIRNNTQSGATLTVEKDVADVLKENGVKLRDISSVIWSHFHFDHIGDIRTFPNKTDLVVGPGFKAAFFPGYPTIPNSPVQEYYFTGRNVREIDFTKQHPPLKAGQFSAFDFFGDGSFYLLDTPGHATGHLGGLARTSTNPDTFIFMGGDLCHHGSEIRPSQFLPIPAHVSFPAAVSEAYHRSRVTTCPGDTFAQLNTQRGRRVDQPFFDPLLGENITAMLDTIKGAQAADAQDDVFFIFAHDMGIDGVVDVFPKKANQWKKKGWGEKSLWNFLAELVPALGPAQAKTCKARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8V8</accession>
    <name>A0AAE0K8V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CmcJ-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_290746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8V8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="276" mass="31884" checksum="2A4D299D7F9E0C18" modified="2024-05-29" version="1">MAIDATVHYIARDEAYKAEKAFDTGFPVSHIPGARQTNHRVEPHGVKVHQIRDPSRYALDVHGFCVIRADLDINPHDAVTQLSEIQFSIWDKLERILERDFPQYTRIESYDLNVRKRDSDFPSITRGYTDFNQPSRKPHCDVSQQGALMDLRFAFPGQDHIWAGKDFDILSVWLPLVGPNSDWPLVLCDWTTVDPDNDIIDNDAIHRDHIEENSLLHYNSAHKWYYIKNQTSSDLMVFRNADSCGRRPRGFHCSIFNPDVSGPPRQSIEVRLVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KB40</accession>
    <name>A0AAE0KB40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_454043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KB40"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="75726" checksum="19DC2483BA39A351" modified="2024-05-29" version="1">MSVQLARNEGHTFEAIQEEEISNIFEGLSCVHRQEQMIKLAQDGLTQARSIMEQGEPLEYKLLLDSIIDEAEWYSLLPRRLAEERQLNEAAYGSMGVNLELKIIEIYKFLIKVNMMSVGRYCSRNRLVTLFRDTVTWDNWKEMLGKITTAEDEYRNSAAQFYPRPVWGAAPNDFEVRLKELDKHTQQQKKLGRDSFMTRPLSNYHTHRDSTRPLDGTGEWFLEHPEFIEWSSWESESGLLGLIAGPGCGKSVLASAAIERLEREGSQTMYDYSVKPQAPTEQRVERLWNILEIATRRTRPGTGSIVCVLDTMNECSSRHSKTFYDRFRRCLENDGQSRVKFLVTSRHNHIGPPGDSLRFDDLASCSVIDVERSESSDESIRSHFHSDVNRFIKHQIATVAKIPSEKAILQQQLCRIRYEPPADISQRVDISAVRCLSRLTSRWPGDVNDIYGLLLADTEEGGLRNRQLWIIFNIVVSAMRPLTLTELQAACAIHEAGSDVISLADTEHLFSEDSMNSFKDIMQSRYGSFFFVDDQQQVTFSHSTVKDFLVLGKPSTCDKLPGHNDDSGISTGSPWGGYIDTVRNPESTPRACQLCQNTRPGFFEWMKSPFFVYSAQYAIVHMDDGSTDYAKEQELVRKMLDCDFGIWNVLSNCFMWVQRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KB72</accession>
    <name>A0AAE0KB72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KB72"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="458" mass="50989" checksum="D381F14EBD647ACC" modified="2024-05-29" version="1">MPPPGIHRGEVSALVRPPTFGDMLAHRTFPIKASSYDACPGEPVVAVQLRPWPRHPSPTNYKPSWVADMLIKSNDVPELLRPGSFWWESLNVAFDEGYAEAMKLDNPQHKPFIDKGFSCVFHVVLREHFAIRAWNMTQRTSGLVTTIMSDIRTDMQSLMVAYLRIYTVSRDMFNDVLLSLLPMQHLREPFGAGKEDQDLTQNDKAMYRFTPPPPKDKDEMINDDGASGVWWPWPWSCEKESKQPAQEDEEEDIYATPPQKFATLARPAPVKATAGKQPAPDEDIYNATPPKKFATLARPAPVKAKESKLPAPVQEKEVYLAVPARRHGTTFAPIEAEGVLAELAATSLEDRPGVNFEEGAVTDFEGVPGVKTKYGPAGWVKVEYGPGAKPGADSRARVKSNDSTGSKTKAKIRSSPGEVNEEDAEYDFLTGLMTRPKMKAPTRRVDKEDEDYDFLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KCY5</accession>
    <name>A0AAE0KCY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KCY5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090554" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="96" mass="9969" checksum="78D03646115D7ADB" modified="2024-05-29" version="1">MQYKLAAITIVLVAAGLTSACGAKNGACDDNGCEGINNPDDGLGYCTAGEFIGCPCRSICGSKNGPCNDNGCNDELHSKLDFDAWAVEDVFEIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDH6</accession>
    <name>A0AAE0KDH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_480571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDH6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF231">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3374604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="498" mass="56948" checksum="44F4F31FEDA8B116" modified="2024-05-29" version="1">MSWVTDKTAFFLATLVVVTLYFIALIINRLILSPLAKFPGPRLAALSNWYEFYYDVIQQGKFTAHIRDLHKRYGPIIRITPTELHIDDPEYFDTLYARSGRRDKYSYFAGRFGGASDSFSTVHHDLHRTRRKAISPFFSAAKITEFQPIIRDTVDKFCTILKSYADGEVIPFSRGLMALTTDIITEYAFAKSYDQLDSPNFADTLHEALVAIYVTGHFALHFPIVFPILDRLPDWFVRSTQPDVLPVVGLRKDLARRIRDIREGINQSHKKASHPTIFHELLYSDLPPEETTDARLGDEAQLIVAAGLITTSAALNVASFHLINNPAVLSKLRAEIATATTPLDWHQLEKLPYLNACVHESIRLSHGIVTRDPRLAPDTELRYGEWMIPRNTPVAMTTVDILMNDKIFPDPKKFVPERWLENPDLERYFVPFGKGSRQCLGINLAMAELYITIATVFRRFDFDFFETNVSDVEMEHAYLVPYAKWESKGVRVTVKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFC9</accession>
    <name>A0AAE0KFC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_496402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="440"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3375182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="495" mass="55397" checksum="56342C7972AD62DB" modified="2024-05-29" version="1">MPTLGFLKKKRTREGNTDPSPPSNPTSPVTPTAVRAFDQTSVPSLTPSHSITSQATSQYGSAPKPDVQVDAAEKQPMNTLPIQQQYAPPQHTPSPGTEPQNLPRISNLINPPQHDGPSPYQQQQIGLGFAPAPVNGGAPGSLPQPPTMAPTQHPQQQQSSAPATAQAQLDQARVTKGKYSLADFEILRTLGTGSFGRVHLVQSRHNQRFYAVKVLKKAQVVKMKQVEHTNDERRMLAEVKHPFLITLWGTFYDSRNLYMVMDFVEGGELFSLLRKSGRFPNPVAKFYAAEVTLALEYLHSRNIIYRDLKPENLLLDRHGHLKITDFGFAKRVPDKTWTLCGTPDYLAPEVVSNKGYNKSVDWWSLGILIYEMLCGYTPFWDGGSPMKIYENILRGKVKYPAYINPDAQDLLERLITADLTKRLGNLYGGSQDVKSHRWFSEVTWDRLARKDIDAPYTPPVKAGAGDASQFDRYPEETERYGQSGHDEYCALFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJC9</accession>
    <name>A0AAE0KJC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_223204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="853"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125234" checksum="EC37860BB381B673" modified="2024-05-29" version="1">MDAKASSVSGLETGETNHEELNREHTTLMIDRPMASQTVPLEVINRAIHNMQAAVEASPRDSPEYSERLHTLGAMLRDRFRLTGSPDDLQASTRSFNAALDATPVDHPDRPNRLQSLAMQRLEIFNKVVTRTTLNDAISAFQDAVDATPSSHPDRPGLLNNFASLLLYRGRASQTTADIYKAVEILGEAVIETPDDHSDRSSRFSNLASALSSLYDWTADMKHLDAAVSGFRNAASAATSDVDGQESLTKQGSLLKLKYRITRSLEDLNEVISTYRAICETPSEDRSGRGVQLTNLGMLLSERSKMTNDRVDLEEAIRHSREAVNIAPSHDTNRVRFAVNLSTTLSEMYQRTGQRGDLDEAIRILREAINAAQPGDLAGMYTNLGILLRFRYNITQALVDLDESVSNCRKAVSATPHDHGDRARMLTHLGVMLGDKYNRTKSLGDLEEAIDYSREAVKTKSGHPDLENCLNNLGLRLGDRYDRTKDLHDLEEAIENHRNAVKKAQPGHLTYAMFLSNMGMRLAERYTRTKKSDDLEEAIRSIQEACNKVPSTNPDRSGLLNDLGNKLLIRYAETGQQKDLEDARASFKQSVRIETGVPLERIKAARALASTFIDDSDWDQAIEAFEGAFAVLKTLNVRSLPRSDQQWVLSELSGISSDTASSILQAKRPASDALEFLEAGRCIITGFAMDSRDEVLELRVTDSVLCAEYEQRREEVSQCRTSQWLGTGGDYDTKAAALQKSLRDLAETEDKIRHIRGLERFQLPLGAADMMRLAREGPIVTFNVSKIRSDAIIVTTTDIWPVSLPGLTQSVLDDIATFFSASGSTSRRNAGVRVPISDGHTPQQKMGTNLLLLWNIAVSPVLSEFTENQYRRVWWVAGGAVGRIPFHAAGDHSEGSRENTISRVVSSYTSTLKALHYVRKKRKDGNSQGRMLFVDMPQTPNYPVLNTQHEVTVTQEEFGDRCTILRHPSRKMVLDGLGDCAFAHFACHGMSNPEDPSGGGVMLVEDGKPILLTVRELDEVNLQSAEVAYLSACSTAELAVGKLIDEAIHLSNSFQTIGFRHVIGTMWGADDDAAGEIAKSFYKLALSNWQGDASFGEYKVAQALHDAVMDFRGKPGMRADVTKWGPFIHMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJL6</accession>
    <name>A0AAE0KJL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_229176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="145"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="588"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3377889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="970" mass="108633" checksum="8AE5611E0CF418F8" modified="2024-05-29" version="1">MKSLRGYFTPAPSKEDEKGGSAEARDRKSGSKVEAKAAGTGTTHQLQPIRGRPPAARDSVGVPPPSVISSLHNGGGDLAGTGTGHVSPMTASARGSMLSIPAAATTAASSQKRSPSNSRPASVRHSLFPMGDSRNSEPDTLMEIRNDMMVNYLYEQQMRKQYASGMDPYEGVVLKKARGNFTCCPPQMAAIPDSLFAMISQMNVRCAMTVNTPVVRALLETLVVQTELDYVPLPDGLRVQILSTMADLPRGQLHHFAAFIEDVRILVVWDDEPEKLLARVQNLEMRFIEMVWGNGEDRVDDEEDDIAQEKKGGVSTHVDEMDPEDGPFKERRPIRLESACIVALTLALCITCLGLGWRAMALETMVDMDYTRWALAAVGPVQLFVSLFFFQALIGNLFQIFGPISAVSTNSKYFSGKAPKRLNRNHHVLPHVTIQMPVYKEGLGAVIRPTVVSLKAAISTYEMQGGTANIFVNDDGMQLISDEDAQARRDFYDEHNIGWVARPGHKPKPNLEAGERLFLRRGKFKKASNMNYALHISNRVEEKLLQINRHSRWNSEQELASYFECLTDVLQEDEGRTWAEGNIRVGDYILLIDSDTRVPTDCLLDAVSEMEQSPEVAITQFSSGVMNVTDSFFESGVTWFTNLIYTAITFAVACGDACPFVGHNAMLRWKALQDAAAYTDEDGYEKYWSESHVSEDFDMALRLQVAGYSLRYAAYTGDGFKEGVSLTVYDELARWEKYAYGCNELLFHPLRFWVVRGPFTKLFRQFMGSSIPLPKKLTICAYIGTYYAIAAAWSLSLANYFITGWFFGLYDKFYIDSFAIYISIIVVFTGLGNLALAVLRYRLNQQSLLSACFENLKWIPMFTIFLGGISLHVSQAILCHFFEIDMVWGATAKEIEEVHFGEEIIRILKSFKFTFIYCFACTALMVCGVYYFPYNWRIDQFFSLYPLAAVVASHFALPVLLNPALMMFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJS5</accession>
    <name>A0AAE0KJS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_230163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJS5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="225" mass="24210" checksum="A6DEF41DDB7DFCD9" modified="2024-05-29" version="1">MSSRLTTPVSKFTRSISSTAWSSRPSNLLNNGTKSAASNNNGSRKRQTRKAVVVEEPSDYSTSAATPHRPTVPSRTIPLMQGFRTSAPSPSSSHAHTRVDFCKLPDLHTPPPSTDYMRVPLLPDNATPPTWSRAPEAVDAPLPKPEILVVAANPELVLPSALTEVEGMGVDGVELKFAHELDNSNTQNYQGVDVQGGMIRDLWKGLMDDVFGADQKGKKGEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKH0</accession>
    <name>A0AAE0KKH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_237299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKH0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="36764" checksum="431DC13E8FB81043" modified="2024-05-29" version="1">MADLERAVDSDKVWTTLITNTDYLPGLLTLDYSLKRAGSKYPLVVLYTDTFPLSGHAALDARGIPKQHIEYLVPSSGSKNYDADPRFYDCWSKLVPFSLTQYKRIVQLDADMLVLRNMDELMDLELDEPGAAAAATTSSQKQKHRRVFAAGHACVCNPLKKPHYPSDWTPANCAFTSQHADPDAAQTSAPAPDSPAAGPLGFMNGGLQVVNPSAALFSQIVTHMDADGCNMDFADQSLLSGLYHCRWVALPYVYNALKTLRWDGVHAPIWRDECVKNVHFIMTPKPWEDKVDEKGRTTSQEITHRWWNQIDRQRISSEREMGLDEDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKJ1</accession>
    <name>A0AAE0KKJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_229734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKJ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="463" mass="49820" checksum="C226F3A009280E35" modified="2024-05-29" version="1">MAKMDDVTGAGSGRNMGGITIFSGGTAANSLVDVFARLVGKRRCQLTYVIPISDNGGSSSELTRFVGGPSVGDIRSRLVRLIPNHESDKEMMAIKSLFEHRLCQDNIQARVEWLDIVEGRHSLWDCVSSQKRDLIRSVLNTLNLEIVKRARPTSVFNFTSASIGNMFLAGARIFSGSFESAIYLLSMICSIPASVSVLPAINTNFTHHISAGLVNGTSIAGQVNISHPSAPTALPDDAIIAPVLTAADHDRIEDANLPGSLPVLRRQHITFSKEDEQDLPARIERLWYISQYGHEIWPAANPKVISALDASSVVVYSIGSLYTSIVPSLVPRGVGEAIAAGDVKHKILILNSKLDRETGPRTDPMTARDFVAAIARAGAESWTTLDAVGRDDSLHKYVTHLVYLEGLEGKGVDGAPAVDVAELEALGITCVRVKGKSVGEGKKVMLRYDEQALGEALEAIIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKK2</accession>
    <name>A0AAE0KKK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_477477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKK2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="696" mass="76987" checksum="1FCF529B7F93C93F" modified="2024-05-29" version="1">MESTSKTRPKMGNGDASVDDFDVADILQVSGTKRQTARDENVAHRLTTASSSRVATAQNVGFQRSQRMGTSLDRQFGSNLQSGLQTGMAMQMDLGTGMEMQIERTAAQVVDTPPAALPQAETNPCHPDSKIDHDALAEELTESNKTIAQQDAAIQHLSSDVEWLEQTLEHVQFELKCARAEAAADAQEMREKQDALEERVENLTRQCDERSASIETLQNRLKEFSDRYVQQDTRINTLETTSRDLAAQRDEMSSRIPILEAAVKEASTHHAQYIAELKSRGIETTALLHRARLEALEEAEKTLGDKWSVVKKEWDVQFANMERSIESLVAYFRVTCKPGDDEETRKHELVLQVKDLAMRRLRLLLWVREKQTDNNKLEEKVASQEKNIKALQSEVNGFTGWNIELQEKAEDLEKELNGVRKNLGAMTHAKEDLGQELRTVSADLRSAQTKVSELESSVAQKEMALETQNQDGQQQQHQQQQTQISGHVPTSLGISTGFDICMAFGGAMSPERFALIDFVRDQMQRRHTYVIEVAPISSPTVKVFQVGPLRHSENSLISSITTTMTNTSNTAGGTQSHPTTGSSVKNTNEGASPNRFPPAVPEPATSAQVTSLRRQSAHSNLSLEPPSAGSTSSSQTSSMPCQHGQSVHSSQSLEPPIVVATSSSQSDPTPRQRGGFFTIRRKDLVRQKGGKDGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KM83</accession>
    <name>A0AAE0KM83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_248694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KM83"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="30310" checksum="246C40330742D519" modified="2024-05-29" version="1">MNVVNMNPIEAGLTVRHKLTSWDGIPQKLRENITRTIIAIENLEAEAAAKPLDMHNKSVRARFNQDLITIVHKELMTGMEFFACYKNGPVYEPIVVKRACELCLLHKYKYQVPVMKESLVKDVDGEESRRAAETIREYEAQYDENVDKLKFSIIDAAMATMWNNNSGENDMGNGIGAFMHEYADKCKQQETKNVDDGGAKDNLSTEKKIAEMVAAAAKFKSEEDRYLLKVSRLIAVANTSKFAEQIVDRMMLSASSDTIDLAQTVIGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2B7</accession>
    <name>A0AAE0N2B7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_363599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2B7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="285"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="589"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75693" checksum="F475432126EC9C5B" modified="2024-05-29" version="1" fragment="single">MEPLAALGIASNVMQIISFGFETIAVCKRVHESGHPEPGLGDNSASLHTLSVALSQQLKAYHQSQVGLRKHDKAMLDIAAKCADAAKALQEEARFLTPKTTKNFANVASTVSKTLWRKRRLERLEKELTRSQATLDTHLLARICTRTEAAQVIANKDFVKLDAILRDFIIRYSSSQAVLSKTVEEESAKLRTQTSQEAAQTRQEITKASVSTTRQLSQKLEQLSIDDERASRHAKLLGSLKYDGINDRANQITANYPDTFQWIFEGFSNVSGGEEQPRPLWPLLSTWLQSDGEVYWISGKPGSGKSTLVKFVVASELTQRNLDKWRPRTHILSHFLWAPGAEPQRSIKGIMSSLLHQSLSENELDIDALLLQFPHLLEKDSFSDWSAAELGKILLSHLKVAGPRCIILDGLDEVSPNDGPFKVIQLVEELKALSNVKVCVSSRPEHILKSHFEKYPHIQIQDLTQPDIQKFTDAYLDAEMGIYVPSDYRRRIVPHLVSAAEGVFLWVVLVLDSLRRGLHNGDTWAELEQRLYSMPRGLSNLYNDMWSRLNDDEAIYRKAGALYLSLAMSWRGNPVPSFNLSILRLMAAAHPSSQLHAVALSPAPELVQMCEKTIKDLNIRCAGLLVLRESSRKIDLGRSEWWKPIQDETSHGCLVQYLDCSIDFIHRTAYDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N336</accession>
    <name>A0AAE0N336_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_565578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N336"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="459" mass="50416" checksum="69CEE30B76D9EFF0" modified="2024-05-29" version="1">MSGAPQPSPATLLTFSRDYVEFNEGPVLTNSCIALSVVSAVTVAIRFAVRWRSAIGLGWDDWLILFSLPHLFSFAAMAILSVEYGGVGRHLPVVMALDPQMFARTMLYLFVSEFNYFTLIAVIKASILVMYCRIFPTRFMKKSSYIIGIIVGLWWFSTILATLFQCQPVQRAYNPFMQEGSCFNISRLFVGNSIVNIITDIMIIVLPAHEVWQLHLPRAQKLAIGGVFVLGFLAVVMTCIRLKSLLDLLGGQADFTQFVAPAWIWTLAEPTCGIVTASLPTMRPLLRFVFGMTFGVGKAGGGGGGGGGGGNNKNAHPQPGAKSPPHSNDTVVTIGGGSFSHRRGIWGSKPFNNKKTKQQPTGTAKVTDDDAENKSYPASTFDKFHDLEKGRWPEYPPNTWPLPGDLVDVPRRPVVISDRRQVQVMISGNSEDSLTPSDEIPLQGISVKRDIWTETEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5K7</accession>
    <name>A0AAE0N5K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_313015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5K7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="330" mass="35357" checksum="702776C6BFC2035E" modified="2024-05-29" version="1">MADSAVATRAPESDAQEDVDVHVPETTPALCDDCTTDRPTPAGHASTGEITKLGDIDVYISKPADYPHTPSRLLLLLTGGTGLKSVNNQIQADKFASEGYVVVMPDLFNGDAAPNSSGAFPEETSSGSSFLDTFKTKAAEAAKSFMIDMWLARHTEEKVLPILHKVIDAARDEFADAVSNGGGIYAVGYCFGGRYIFLLASERPVPVQGGNMPWSAAAAAPTDEEASKPQTLGPYIKAGAIAHATLVSRDDFEGLKAPISVVSVENDPMFPDEVRTAGEDYMSKNNVEHEVQVYPGVPHGFAVFGDYEDANIKTAQGTAFEQMLKWIREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCT0</accession>
    <name>A0AAE0NCT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_547547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCT0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="729"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="864" mass="95053" checksum="DDD5CAA8EA8676F1" modified="2024-05-29" version="1">MSRPQVSIERLPTRRMSNEPRESMNCKSCRKRKIKCNRLRPSCEACQVFQCPCIYDAVPKKRGPKTDVLEALLKRVDGLEARLKEKKAEPEIPTSEDAPEIMMDESSSVAPTSDPVANDKMLGLLSIDTNCRQEAGESEIYSPTHSSEPSPKIQPDADALLDTYFTRFNAKPFHILDETTLRERLQMNQAPGFLVQAIYAVASRYTHHPNGYQSAVKLSEDFAAQSRLEIDTDEPSLDALQALVLLVTAFTAAGKGKKAYMLLTNAVGMAMALELHREMDLTARVSPVEREMRRRLFWSCYLLDRFMACGSKRPSLIGDKVILLRLPCWASHPSSPLVEGEFFQSGSNLQYLQGSGKKSQGSSGMLIDISRILGTTNRYLAAGGVKGDSHFPWHSLSNLSKIRQELDVWASGTDDVFSSVDTLFGQADSTVLVLSKLIYHLIHCLIYRPFLPIDLSELAGSGQHQSWQIEATNMCFLHANAIAELVELGKRTGSIEWPAFVGYCICTAGTVHIHGAHYSRNGNAGEMNVFNSSTNFLSREMQQLSELRYAWASVQHQRETLQGIYNAHSELVKSLSNNPMRYSPVFHLEDFFDRYSNIGGPGGQTFSFDAANLSLSDVVVDFTADTYTGYDLYAPRVDNTDASLRLPSLKRKNTAPPGRKRPDFKDMSPFSVNRLNPPQSPALTTPRHHSFPTPSMSSQASPGMLDAPNSLVPHHDIREQQQMNTISETTASTGYPSSSQTHTGTSNHGIPNNPSGTLFSPSFNFAQLRPSTPASSSFHPGYDPMFGGVPTNAFSSPAPWHFEDGSGSTNKPQELAQSPSGRSTGPGEEKDPFLSLLEQLAENESGAGLGSELDFFLAGAPSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG60</accession>
    <name>A0AAE0NG60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_434214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG60"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="313"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3380865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="443" mass="49109" checksum="6BB17D3D7EA5B6A6" modified="2024-05-29" version="1">MSLQIPHREKANGNTGATKAVILVGGSSRGTRFRPLSLDVPKPLFDVAGHPIIWHCLTAIAKVPSIHEVYLIGYYEESVFRDFIKDSATEFPNLSIKYLREYQALGTAGGLYHFRDAILKGRPEHIFVLNSDVCCSFPLNEMLKLSQEKDAEAVILGTRVSEDAASNFGCIVSDAHTRRVLHYVEKPESHISNLINCGVYLFSTDAIFPSIRSAIKRRTDRPSRLVSYPSSENLESSFMIDDDDDENRKNEVIRLEQDILGDMADNKQFFVYETKDFWRQIKTAGSAIPANALYLQQARQNGSKELATLSENILGPVYIHPTAQVHPTAKLGPNVSIGPRVTIGAGARVKESIVLEDSEIKHDACVLYSIIGWNSRVGAWARVEGTPTPVTSHTTSIIKNGVKVQAITILGKECAVGDEVRVQNCICLPFKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGG0</accession>
    <name>A0AAE0NGG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGG0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042201000" evidence="1">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="385" mass="42911" checksum="F4FEA6CB23BE367D" modified="2024-05-29" version="1">MKLRIAILLLSGVGYGLGAALLSTDDGPTPAKVESLEPKYFKDLGAKRVKITYGPYVVPGNADPETHGMKLFQDMNAMMPCHECLITQYTADLQFINGTSANANKNMWLHHIGLMNLHRTDAACEEWPERMSINGNERSPVDMTIKGTRKAGYYLRKDDQILLSTDAMNLHPQAQTVTLVMEWEYIPGTPDDFDIAVPVWLDLRGACLNESRGARESDLVFDAKTTSPWISQFAGDLILMVPHIHDGNTKQEVYLNGKLVCRNVPGYGETSGYITHLEGTGEHHDHGKDSHVLHVSSVSQCRNVGKVVPGDKFSLTSFYNMTEHTPMMNHDGSFETIMGIEFLHFARPRDEVVKEILAMKPGSLQSFLDWVTELDAQPPVFPLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGL7</accession>
    <name>A0AAE0NGL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_450481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGL7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="530" mass="60921" checksum="9A5E60109CB04D6A" modified="2024-05-29" version="1">MASATSGDRSAEFVAGKLGNFSSVLFQVNACSGKYSWRDIIDVAKQHVRCHPGDECLKRRGYVLDELDILADTDSSTIWPRDQELAPKDRIPDTFLPGCQSYRLGMKPPLSLEDILDDSKSLRTSWEYSARWSFCQFLRLPAEIRHEILLSLVEPIEFHGIFQANRVARKINFKAANIRPVDAPLFSERGTNSSTLWNISHESRDLAQRLWSARVPRADHGDHRIMRRDEHEKTKNFKLVMNPIKDWLSFTATSFAFWGGCNNREPIEVHGRPYDWDREDPENLARANHDHKMFNHTPLLDRVQNVSLDFRYEPGAMQVSDNPLPQVRLVRFLAENCPNIRRLRIVVRPLDVCVYYPENFVLMANQGEPWFTQSSFNDRPPSVVGSDGRWRDSVHKITIFEPTQYRVFSRPRLHLLDALLGAGKIPGKDGEYIVPFPHLKTLEVVQADYVTRKGIWRGWSKRGGCSESLFISEGFGTGMQYFVGCRHQNVPYFKQLIGLQGPHSETVSVDFPETDPFEGLTEEVGWRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGZ3</accession>
    <name>A0AAE0NGZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_475148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGZ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="565"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116404" checksum="43079F331234E65E" modified="2024-05-29" version="1">MDPLSALSLTANIFQVIGFSIETVRISLHIHESGTLATISDLERASANSQKAAKTLATSASGNGQLSDALEQDLSEMTQEALHITSELDSLLRKLHGNRFDKSRSSTALKTFRVVWNKDKVLKLQQRLHGIRDELQFHVIVSIRARMGEQSLRLDDALQSLDNNARAILTPIVGSLSTLEGQSDAILTRQAQSEASARERHDELLTTINGLSLTAHGQSELPMEGPPETPSDVDIDRRKKEVQSAIMSSLWFPSMQDREDAIPEAHKATYRWIYREPIVSSRKWDHFGQFLWSGSGVYWVTGKPGSGKSTLMKFINTNPETNAALKIWARGRKLLSARFYFYYNGSTLEKSELGVLRSLIHQLCWSDPELIQIGFADRFEAMCLRSQPPSPFTPTLWELKRVLKAIVDQKSKDLCFFFMVDGLDEYDADSTEMAMLANVLMTLSGLEHVKSVLSSRPLQVFEHAFGECPRLRLHELTLPDITALVESKISRHPGLRRLARESPADSEALVQEIVDASSGVFLWVQLVINSLTEGFQNHDRIDDLQRRLRDLPTDLEYLYRHMWDRIPPYYRPQASRLLQLVATATRGGGSISVLGLSLAEEQNEELVFSCPTAPHTAEEIDSRHEDVRAWISSRCMGLVEINGSDHILSGLPGRMSDLNYFCEETSKYKDTHVAFIHRTVSEFIAIPDIRDDLYAITQYFSPEQSLCRSAIHLVKRGSFKSNGSRGMPAALGYGACNILVTARVAEDTTKKSQTRLLLEFDNVMVRHARTYFPAHLGHWSDLMGRSRLDKASEEATAENCNNFLSLAVRFGLIFFVQDQIQFATPSSGHHSGSGSILQKSGRPLLDYALRPDAVDRIFWYLNPESRVTHLSTPYPDLIELLLSHGCDPDQVFQGKTLWKWYVTILQEFTNRDDDWPLFVEVAPAILGSLLRSVRPENRNVYLRRSTTVVDLLYLIANRANRLPNTRIEPLRFRAEMQQICELIRAGEQTTTVTQRAKHTTVPALAGAGAGAAKQTRKSPFQYIKGLLMGRNPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHN8</accession>
    <name>A0AAE0NHN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_211252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHN8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="701" mass="73853" checksum="CD784BC5EEEC4AD0" modified="2024-05-29" version="1">MDDLSRMSDVEFDEAAVMTDDGKEDSVSTSNNGIRSPLSKTRSLSDGGGTPKLTPSPHIFEAARQHSKDDIGIRDKDRDVSSLPSTPVRAKFPLRGLALQLPPREATSPAQNANAKPAPLSPKLDHSHIYASPTTNILPRRSRGLDFSRAATSLHHSTLADQASPDSSPTIGSRAMNIPGRRNGDYGNAEQSSNSLWSMMGNHQDRMHISSSLGSNTHMGSDSSSSSEPDDFMDEDMDEAYITTPQAVRPTALHGAPWMGPGGSPAVNSLLSFQQRQRQRKLSKKKMRGPLGFGFHSPATAATMSKSPPNNMASQKEMPTPHARRESISWAANQLHISGNDSDDNTNRPSDSPSVIRRPVTRRGNLLPKTKGFARIRAALAEETAPVEAEFRREAEVIRQVRESDMDLEPRIPPSHSAATTALSSPNLTTHDSMEEVPEDVMMIDPTVGGGSLGLTGGTFKQQAMRNSKGKGFWDTFSDSGSAPRITPPPPPFGLLARGSSAGLSLEDVSMDSPSASSNGASQNNPFMLPGGAQTTTSSSGNGTPQPLICNGGNAAAGGGGGGMPSVPGPPTAAEITRRINSKRRRDDDFDPVSFKRRAVSPGMSVHNSPIMQSPLQRDMAPWGTGSRPGSVGGDTATKPGSASGAPSENGSGSGGGGGSSGNGNNSNSNRLSMSGNSHKVRVGFQGMVDTNDGITRLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI51</accession>
    <name>A0AAE0NI51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_546597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="579" mass="65061" checksum="878D79940746400D" modified="2024-05-29" version="1">MTYWSLIFPQAMEEFKKMPDAKALRNREPKYNIRSDQTWAAVYHDRFRSKSRHVWRWTTENATETLRAGTRLVPQMDMVTPVVGAIQVILEAAKISAEVRKKSLDAFDDLDGVFSDVEVFLSTFKGEAESPGRRSTLMRGSESLRRGKDYQAEHLESLTSITSESKRLVAEAVKTHIHDFHEYSIVTKPIQQLIHRGQGDIAVAVSSVDFKMNGLSEQTPTIIDQGTQIQVTLNNMLGILSDKHDQEKRRLQQELAVAHNANKYLVGVLRSVLPLPHAQPQYQYHQYQAARQQRSSLSQDELWMLLGMPTDIDAEDMALSEARREHLTLKERARAQQIVVHCQLFQDWIVSPTSSKLLVHGDFFSRAGMLGAATLSLFCTSLAKAFRARPDYLYTSNFDDDYTDRDEEDASSGGVKNTRTRSSTAIRKDPVKRMLKSLMSQLLCDYDFGGAHANLLPPGIDQSLPATTTLFCVIDGIISYEREELEEAMLDALGDILGLTVGKNSGVAAAVKVLLTSPRPTSTVRVAFEEEEEEEEEEGGLDCSSQEVQSWILSMQSLPSLPWTPSEARLNRELGVEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NIA6</accession>
    <name>A0AAE0NIA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_476986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NIA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68884" checksum="66864F8A417191D9" modified="2024-05-29" version="1">MTSRAGPSSSSSRSPAKAAAPSSPMGGGGGVTAKSTSDPVLRNALRYTISAREYALLHKYVISRSRMLKRRAPTVDTVQKIMDGGPGPSPPGGRGRAQSSSAAKGKEKEKSSNEGGGGSSGGVAAAASAAMRGADDYNARAIRHSIRVFVATGALMKLWGIVQSRLMGNKQDPASSNKKRQPLHKSPTLRLSLSLSTILLMYRLLFRFFTRLRAHLLDPTAVPFRKRNPKTTSTLTSPYAPAVGASLAGLALGVYPSQQLRVSVAVYTLFRALEFGWNCAEDNGMVWGWEKGISGKPDRRRARPWWWGSWMLQPLAFGQLLHAVVFDRDCFPKTYGDFIFKHSTSYLPTKPEDFPSSLRWPGTYEIVDSLAQMAKLNWPAFISPTLFPGKEDTLPSSLSAIGPLTSGAHPLINSLSCATLHPADPSCTRTFLTFWLHSFPPVTRFLLLLYSAMLLPRFKSLYHFPLSTLHRLVSSALRMSTFVTGSIATAWSSICFFQTWFPRTFLPTQRFFLGGFLAGFWALMERRKGRGVFLYSARVSVDSLWKVGVKRRWWRAMKGGDVWVFVLALMLTGVVYERDARAVKEGSWRKGISWVRGEGFKDWAVEEEEEEEDVEEGELKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNW9</accession>
    <name>A0AAE0NNW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_472135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNW9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="207" mass="23542" checksum="37B5EE1F0F466283" modified="2024-05-29" version="1">MASKGKETATRKEAAPSNPRGIPYAPFVDKVEDYVASHADVEPTLRSFQEMIAKYQFMEQNLQRRVGGLKDKLPDIQKTLDTVRFLKLRKDEHEPIETTFELNETLYAKAEIPPTDEIYLWLGANVMLSYPINEAEELLSSKLQAATTSLSNCEEDLDFLREQITTMEVAVARVYNWDVVQKRKDKEEEQKAKETGKGKDIEGKPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPA4</accession>
    <name>A0AAE0NPA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_178766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPA4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="39465" checksum="58491C9A1DC1022C" modified="2024-05-29" version="1">MASTTTSGLTRRRGAGGGGGGGDDETLSPGSGSIARSNSSNNVRDGGAPETSYESGENGHKIAFDPRDISESEERSKQPKLTLMEEVLLLGLKDKQGYLSFWNDNISYALRGCIVLELALRGRISMQKDPSRRRFLLPDRTIEVIDNTLTGEVLLDEALKMMDSSEKMSVNSWIDLMSGETWNLLKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVVDGGAKEDIRRRVRNVLTQRTVVINSSQFLPENVEFRYLRTIAMVCAAYAANVLENALSTLGHDAREKAFTQTDDLLADYSQWPFGKKATANGIGANIPQIIAEEVSKSGDKELQLEVVAACLSVFTRVDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQC3</accession>
    <name>A0AAE0NQC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_187636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQC3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="216" mass="23492" checksum="6BCFB0B7ED9F5AC5" modified="2024-05-29" version="1">MILYQGLTMLDVFGPLEALQQLSYVHKLNLYLISDNLDTVTSEVPATENPLHSHFFTNLKPTHTFATVPSDLEVLMIPGGAGPVGGLRALNSTVDFIRTTYPKLRYLITICVGSGLAAQAGVLDGKRATTHKGAWSTIVPLGPNVTWVHKARWVEDGNIWTSSGVSAGIDVTFAFIQKIYGAENATAVANGIEYDRHMDPDWDPFSDIFPISNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQT3</accession>
    <name>A0AAE0NQT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_189729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQT3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042057738" evidence="1">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="345" mass="37436" checksum="040C5752363790CF" modified="2024-05-29" version="1">MIQVLISVLLFVRTCLSIPFGEWDHGRVALNDVSIHFRYAGSGPPLLLVHGNPQFSLTWRIIGPILAENFTVIAPDNRGAGDSSLPPDGNYSATASAADLKGVLDFLNITETYVFSHDKGVGMALALAIQNPGLVKQLGVAEYILPGFGYEQAQAPAPYWDLYANWQLAFFSVPDAAEFFIRDREKQMLEWYFFHGSYSGVTAFTEDIVNQYATSISKPGFLRAMFGPFDNKAIAADASFFKGTIGKKPLSIPTLSLGGEASLGPGASLVFANVSTNVEADIVPKAGHWIADENPDWVAKRIARFLSKDTSPLPKIDLSYLKDRVTLTVGYFGTLGNALLASQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQW2</accession>
    <name>A0AAE0NQW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_510651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58160" checksum="2C6A6EA97E0CB6C3" modified="2024-05-29" version="1">MDHQIQARALCRLMLQHAGFPRGRSFDGIGGRLADRVMVVHRGNKSINSKDVFPILGLPTEIIVMIGELDQDTMAKLARTNRHLHQVLNHHLYVNNVVHLKSSGLVRTVRDGNLPALYRFLSVGANPNITTPTVVRQPRMSEIIFIYERLREEHSDCTDSILEMAIKSGMVHAAKALILAGANVFEELPMDKVVPPSTAAIYLMDRGMVRAPYVVASMNHFELAKYTASLVTIALFRGDADMATMLLDNGFCDGAHHPIIFLPSAADDGHNTASNIFYDSDNDNGNNTNANPAVKVERKSIDCLSFACTLREKPEMAKLLLARPDTDPNARDSQGLVPLFWALYPQSLVNKRSLPQNNPSFTLLDMNLIVHILTDLVIAGADPDISVTLPGDFIDPSLRGQTRTIRQLATIASHHDLCVRQFFDLLPEDKDERVQHLSEDGKWMALNSVDRIMDRHFHHVHAIYGRESVTKGTLGGQRHAMMGSDEQGLLRMAMGIGALAERAARLKKDKEERKAKEAQQQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRB2</accession>
    <name>A0AAE0NRB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_191903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRB2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="661" mass="72431" checksum="100C89B9FF6FDB95" modified="2024-05-29" version="1">MDHQYPSPGSKPYVVDSAQEKYDNRSTSSKDHGEIKKSAWARLNETWIWEFFGFLIAAGCLAATVLLLRLYDRKLVPTWPVTLNFVLSLLGNVGFAGTLFGVHAAVAQLKWIWFTKGPRPLMQLAIFQKARGGPLGAIQLLIATGAQPVVITGSLAIILGMLWGPFTQNLIRYETGNVTVTAGFDTARLARSEVFAGHGATSAWEERYPDPFLSLNMQTILITAPSTEENLPKFFCSTGNCTWPAVTTYAFCSRCVDITPQIDLQCKTDFPPDEFRTFATPQQACTVTLPKGTTSLLVNTDTSNNNLMNVTNIYTKEDAVVFTNSTSPIFQSLRLLPPYPLMGLGAPSVSKSNFSATECTLNPCVLSLQASVSGGIYSEKIIDTFMESPKDADSNWRRHVLQPPWGPERGIDRSANVSFGLDESVQFDWSSHGFPYFDIAGDATTTDGNTGITFTGITSKEGLTRYIYNANYTAKACGSPNADTFACAMDGIADAMTKTVRNAGVLANGTGAGSAFLAEGQTMTSATFVRVDWRWILLPAAVWFLGIVTWITIAIQTRRLRLPTWREDLLPLVFLYRGNENEQQQQHHAQYNGNAHSEQGGGHVARTATGSLQHDEVLKADNHSSWAYGNVAEQMKVQLLPPKSKKSPGGKAGVMQFIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRC2</accession>
    <name>A0AAE0NRC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_393508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRC2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="251"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="944"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113871" checksum="6AF773ED288BF5D7" modified="2024-05-29" version="1">MAHAPLLRTNTAPGFQSQLDGVNRQNSTTTMSLTGATPRVSKLAGSTTFPSTASLTSSIASSNTTNTLVATPSSTPVNGQVVATSNIINQKADASRSLYQICVSLKQRLAKVPGFEQYTEELNQMAKDPLEGGPVESLWKLLRTGYPLIAIYNVLRQDNPLVPDEKPGASADKKSKIAIMTFVSACRRELQLPPEECFIINDLTGTDTTGFVKVTAVINHVLDLAEGQGFLLQNQPYPEDDTMQPTSKMSYRDYIIRELVDTERKYVQDLENLHDLKKTLEQKGVIPGDVVHDIFLNINAILDFQRRFLIRVETTNSMPVSRQEWGSPFVTYEESFNIYQPFIANQRKSAKLAGQVFDKIQAAEHPVACDFNTLDGFLLKPMQRLVKYPLLLKDLLKKSEDEKVKTDLAAGISSAERVLQKANEAVGRDLLDEALEDLITRVDDWKNHRVDQFGKLLLHGVYTVITGKSDQEKDYEIYLFECILLCCKEITPAKTKDKKDKTRSTGPKVRNKNAKLQLKGRIFMTNVTDVVAISKTGSYTVQIWWKGDPGVENFMIKFQNEDVMKKWAAGLDQQRKDNAPSVEKSPDQAPPNFAWIASVSSGLENPYAGQDDDDDDETYGITPGTTPTPSMYGGAAPPVSLPGTMQRNGSSTSLRQRSATGESTQSLAGIVRAPPPRFPLPQPPAGLSVQTQMGAMGQAAATPRGGESYFSPVAESPASSRTSTTSGFFGPASSSYPFPNTSNPNWNPEDHNRYTAPAMPRASSRDGPSPVNAYGMVNGRNPRGPSMPVLSRESAQLQQQRIRSYSTPDINGQSNGRSSTQQVPAVPGIPAHLHPTHSRHDSSIPRSSAGSPANDLPLRTSTSSPSTQRTRQYGGTMAQFPTQPIYPRQGTPGSGTSLPPPGPPPPGMAPLAPDSSRVAPPALGTAPIQGQNVPQTPSFPAPTQMKVKVHCENNNYVTLVAQFNITYQSLIDRIDKKLERFTSSSIGKGNLRLRYRDEDGDFVTIESDDDIQIAISEWREGVRDIHSQGVGEIELFCESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS72</accession>
    <name>A0AAE0NS72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS72"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF3">
        <property type="entry name" value="DUR32P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="17406" checksum="8D0DFE9CBCB6DC67" modified="2024-05-29" version="1">MSLSHSLDTTGVTLVPQATGYGPLIGLGVAFCGVILVAIKIQKAYLSEDSATSEMFMVANRSVGTGLTASAVFSSWMWINETVFCAALCYHYGIALPLIALMAVFGLLARIRVPYAPTSMEIIRMRHDKVAHVVCIVLNSANTSASSCSTKLNFNPTALSQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSG1</accession>
    <name>A0AAE0NSG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_139706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSG1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="89995" checksum="5193BB1D6F62023F" modified="2024-05-29" version="1">MDPISITASCMAIISGIAKSTVTITTFTRKCRDARSDLTRTSAQLAELKLTLEFLKDDFSDDGGGDKRLPHTLQAQVASILRCCHDALREIETTLEKYQNHSGARWALSGADKIAALNQQLEAHLRSLNIALDFIKLSVVQEIKTDTGDLRVDTSHIRKDTALLPTIRGEIAQLQADLGALRTQLASSGPGDHQNSWAIQRYLDTATAYCESIAGGTLIETPESPEVGSSPVEDEKPLYPITEDPVGGATAEAVDNGPRTPTPEPVKGDKPPGDKRTACFEDLKSSKYMGTKRSSSRPRQSSDLMLPMRSASPANKKSLPEPPSPPTKDLPNPGAVRGFNDDGKGVWERVLSSPSHQHKGQPFHIGTVSAFHFDVCHARGLVATCPITATNTENEIIIFQLPDVSTVWKTIACPTRPTILRFSPSGTAISYLDHEGLGVVDVDSGKLYTFASDHIKDPVPSLNWRTPQWPYLEYVRFGLLFSQEEQGDFRRTGFMATFTRTFAVWWKICYNTRMVNKVVTKEVPGMIYDSTYGCYSISTGISRDGNVLGLIQVQRDPKKLIGQGAMDIKLLLAYRDDRTPRVIMLDQKEKFQSYVLLPIPPGVPGENNKLFLVRTVTRPDMDLKNPDQSWPDIELSAAIIQPSEDGADQAKLDWSDSGSNILVKGSLMEDLMVGVANLSDRPSIDLEKSDDDDDDDDNNSDNNLMWHPVSWKGSYRMISLTTKRFIFGMTFTDPTVPKGDKFLDPWVRNRYLVLFDLFGGSTMQRICNPIHLHSTKGEIHREEFVFCNGIIMFCCDRELEFWDARGLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT85</accession>
    <name>A0AAE0NT85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_155159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="38412" checksum="E496CBDC249C0CA7" modified="2024-05-29" version="1">MAASFWDSTQRRHWLYTREELAAIRYKLEEEDPTSLTHTFPLPDLRHLNIYFNQQMQRLGKRLSVRQQALATAQVYIKRFWTRVEMRRTNPYLVMATAVYLACKMEECPHHIRIVAQEARLMWPGEVQAMDTSKLGECEFFLISEMQSQLIVHQPYRTLKALESDFSLSPDESMFAWNLINDHYQTDLPLLCPPHIIALTAVMLALVLRPAPGERPSSSSINTSSLAAAAATVQQAQARAAALSASSSSSTGLGSIPGTHGLTPQSSLLSESSSEGKKVPDAARLSKVQFFAAWLAESTIDIEAMVDCTQELISFYEAWDNYNEKFTKESISRYIKARGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTG7</accession>
    <name>A0AAE0NTG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_493677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="344" mass="37499" checksum="65137940CC0A6D69" modified="2024-05-29" version="1">MGSLKSLEKARAWLSECNGQHGECPRADFVDLPTRLVQVSPPGSPSAARLRLTAGEKGRYATLSYCWGGIQPFQTVTGCLEQYLDELPCKCLPRTILDAFEVTRNLGLRYIWIDSLCIVQDDLRDKAAEIPMMLRRYEDCFVTISAGSAARCSEGFLNMGLNPINHRAWTLQESWASPRLLVFSGLAVIWKSELHWKALVEEYKRRTLTFAGDMLPAISAIAEKFAPFLGGRYLAGLWRDHLVLDLLGSCSGGYGQSNCLSPTWSWVSQAGRINFIDSGFQYPRLLPSAAIVDCSVVLASAAAPYGAVVSGEIVIEAFLANITGNGGFIAASTLLDTGSGYGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTQ0</accession>
    <name>A0AAE0NTQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_392224</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTQ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="163"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3387492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="35439" checksum="BF896E7027AB2284" modified="2024-05-29" version="1">MASKISLKLSSRTPKKPIKKLPAAVELPRDATVEDAKIQIARQLGYGDFNRIGLFDPMTKKILKNRMALVRDEAGVISAGELVVKDLGPQMAWRTVFVVEYFGPILFHAAIPYLRPYIYAPFVAKGAADAPLTLVQWLLFALFQLHFLKREYETLFVHKFSANTMPAFNIFRNSAFYWLLSGLMCAVDIYRPGSLSARDELVPLDYAGLAIFAVCEACNWIVHQHLASLRKPGGTEKGIPNCIGSNLVTCPNYMFEVLAWVGVILISRSWAVVAFISFGIMYMRDWSKGKEKALRNEFGDRYKKKRYTMLPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTY6</accession>
    <name>A0AAE0NTY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_163293</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947483" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="345"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3387677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="515" mass="55918" checksum="FAC331E2D63DD70D" modified="2024-05-29" version="1">MASLFWLLVAALSVLSNAAVTIFPQKEAPAWMMKFQMVLSLAAADGEANPLSFSVYPLTQSVGLNGSDPEKNAISIRGAMIKAEPVNFDRLNNSDSIAYLCCDPSNSSDTMNDMMTIKSAAILLYSMSGDCCGLEGSDFPYKSIFTMANSEEAIAALKVNDDAKGSPLRATIAGNATDAKPVEETQSGNNSAVAMSILYSITGLITLLFLAIIGTGAIRAHRYPERYGPRSGYGGGPRQSRAKGLARAVLETLPIVKFGDTLPAKPDPDLELEHQPSRSSHDPATGTRLSAIPEESQTPRRQSHAAPIAGAELQRSGALTASQGANLAKIDESDSHSQDDEHLGCSICTEDFTVGEDVRVLPCDHKFHPPCIDPWLINVSGTCPLCRLDLRPQGEDTAATGFENLGELAPPLAAEWNEQDDSTAGATPTQRRRASRFLDLHRLRHASVEERIEILRRHRSQQQPASAGSQPDHEERGRRARLADRLRDKFHIRTRAQSPRQTRPIEEAQQVERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUD1</accession>
    <name>A0AAE0NUD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_470934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUD1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="332" mass="35264" checksum="BD2C193F8744C527" modified="2024-05-29" version="1">MSKQYLTAHTVDQAHTADIFSLAPTPTVLFSASGSSSIHIHSTSDPTFPLQQTLTNAHKLGCHHVCAARGGVGDVVASVGFGGEIKVWRRHEDGKQWKLWWEITPTKSSGGDVWAVALTADEGYLACTTSDGCIHVWDLVARERITTYETGGSSGRGGGSFAMAVDISRDGKLTASGHQSGAVYVFNNDAGRLVYSLSGLSKPVRAVAFSPGGKRLAAAGNAGVIALYDMEHGEHVGNLTSPNSRPAWLTSLDWNDTGAYLLSGSLDGRVKVWDAERGICVATHSETDSAIWCVRWLPMSDRVLAPGMAKGEMFCAAGASRSISFYREATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX44</accession>
    <name>A0AAE0NX44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_96212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX44"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8783" checksum="0A3DBA1D4064DEB2" modified="2024-05-29" version="1">MRLLNAKTFVLAEFAVKPPPYAILSHTWGDKEVIFSDIHELIAPRKVQFCDQTWKKSGTQVSLEALLMSKTGIHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXQ8</accession>
    <name>A0AAE0NXQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_518904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="15310" checksum="DBD4FA581CD739B7" modified="2024-05-29" version="1">MSAAAQILTGTLVSSPPAIQVKAPGAGKIVAEWGYVFIRIAWVASGLALAAAVLWTLIIRRDHRARAGAGRSRMSGFATRRGGDGPRGFVLRRGGRSYNGLSDEQEEVAGLRQSRARSRDPSPVGHLEREPSPYEPKRHLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXT5</accession>
    <name>A0AAE0NXT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_537761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXT5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12038" checksum="9148BE10D1DA524C" modified="2024-05-29" version="1">MEASHPLFSSDSQAACVRLTDGPLSADAADIEYSAEDDAVLEKWVQENVQSTWHSLGTCKMLPREEKGPVDASLNLSIVPRNVAASTNSTALAIGKKAADIFTRELSSMWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXT9</accession>
    <name>A0AAE0NXT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_98425</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXT9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041960723" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="22"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="210"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3389400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="65592" checksum="FA2D7E8D5A829AB8" modified="2024-05-29" version="1">MWHSFLMAAVWALSIAPSVNAAPTVFVEQTKRLPVGWKFHSYPKGSDTIAISVALRESNIRELKNQLFERHRRGRPDFGRHFTWDQVNQYRKPTRTVVDEVSAWLKSNGIRDFKTQGSLIRFDATVKAVKSLFQADLVYYSFGNTNKPVLRALSYTIPRSLRDDIDFVHPLTNFMPPHRRKQIMQPVAPPPKPDTHDDGAYEADLPCMTGTFPECIKKLYNITYTAAVPSPARYGVAGFLEQWISYKDVADFMGVYTPELVSATPAYNFSVELFNNGINPQDSPDAAGMEASLDVEYAMALGYPSQVTYYVTGGRGIKLDANGTAMPETISDNEPYLEFFSELLAKPDDQLPHVLSISYADDEQGVPKAYALRVCDMIAALTARGVSVLAATGDGGAAGTGQTQCISNDGSGRKMFMPTFPASCPFVTTVGATDNVGPPLTGADFSSGGFSDYFARPTWQDEVVGPYVDAMVAANDERLPLFNRSGRAMPDISAIGSGFQIHWGGNTGEVLGTSASTPTVAAMISLVNDARLRAGKPSLGWLNPLLYSAKVKSVLKDVTTGDSGGCRFPDGVQSPGWTSEKGYDCVTGLGTVNDFNDFLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXW6</accession>
    <name>A0AAE0NXW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_464110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXW6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="79"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="576" mass="62400" checksum="FDC35EDB57790AF3" modified="2024-05-29" version="1">MASLPDASANVKLGKAFASSRDSLRQDMEGGGGGAEGLNTVTSNGQLFPTPSRLDDGHDGDLLTAIEDRDLQRGLAQRHLSMLGIAGSIGTGLFLGLGFAVQTGGPLGALLGYAAIGLVVCAVQFALGEVAALLPVTGSFVRHAEFLVDPALGFAIGWNLVYGNMLSIPSEITAICVLFQFWTDINSAVFIVVFIVLTVGVGLTLVRVFGEVEFVFALLKILLVVFLVIMGLIINLGGVPGTERIGFRYWQDPGPFVEYIAAGDWGKFLGFWSVMTGAVFSFAGVESLAMAAAETRNPRRAIPRACKRVFARIIIFYMLAVLIVGMLVASNDPRLDGSGDNVAQSPFVIAASAAGIPGIASAVNAIVITSAWSASNQSLLAGTRVLYGLALKGQAPKVFLRTTSWGTPYMCVGLFTCFMFLSFMSLSKDAITVFWWLVRLTSAGVLVSWSSILFNHIRLRQALRRQNIPASRLPWQNWWTVYSSPAALVMCIVILFTSGFSVFTKDNWDPATFVSAYLDIPIVLIAYLSWKFLRRTKIVSLDEIALKDAFEQAEQYVEEPEGKKKGWIRAVSWIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY46</accession>
    <name>A0AAE0NY46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_103742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44436" checksum="36567FA65FE5034B" modified="2024-05-29" version="1">MSLTLPTASPIHVAADISVQTPLSRRGTGPGLILVVADDIDLSTHSKTLDPPPLRKWAEEGYAVGQILLGTSDVSALSGKIGVTLAELERLDGCDSVDKVGIIVISTEAPASLLNAITSHPNIVASVFYGCHPATELSIPVLCHLPKETQSSPEGQTPPTGKNTAIYKYPATAGSFFTIPAHNDYRASSAPVAHTRSLSFLKPLMGGQPFFDLEAIWEEHTRLEFADRDVEATMATMVAEPYVNHVPTLTGGVGRKSLTSFYRDHFIFSNADDAALELVSRTVGVDRIVDEFLFNCTHDRVIDWLIPGIPPTFRSLTIPFTGIVNIRGDRLYHEHIAWDQGTVLRQLGLLPEYLPFPYPVPGVDDASKVKNFEYRVPVAGAETAQKLLDENAVASNEMLQFAVREVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYB0</accession>
    <name>A0AAE0NYB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_464454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYB0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="33941" checksum="F6972CCCC6430489" modified="2024-05-29" version="1">MHHQTPNSMNSQSGYDSYSTTPQVVHNEHGQDGLQVVQDWNDAPYPLPKSHMGFSESPNTHVEMTRAPELVPNGQGPDGLQHLNHHRVTQSPMAYAPASYVGSFNSYTHDAEHVKPLPEQPQKRLGPLGRMKPLTFWLLVVLVSVVVIAASVGGAIAGSNAKTSQAQPLTTTKPEGSAESPTTNSPASSTSSFTTSSTPSPAATVVMVAQKPTSDCPDSAGQVYNSTFLLGKQGAVPANAGLQFVKFCTRGNQGTIIGSAYVPTLEACIELCASLNFRAGNKKCVQVNYDIRSAFPFNCFAASTANGKEVAVDGALLVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYJ9</accession>
    <name>A0AAE0NYJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_519403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYJ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042082484" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="646"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="727"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="817"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="781"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1262" mass="135666" checksum="EA5EBBD841033F76" modified="2024-05-29" version="1">MSLLSNPGRWLLPLLCLRFPQTALAIQLLSATTAPDNVSSGCLSALTADVPCGPLVPEFRTGYYYDEAMLNSSCTTQCEAALATYETSIVSACSGDTWSGYDDEGGASLALIPSIMRYQYSLACLQDSGRWCNVVAGIAARIADPGDSRGRFTQDVTGNGTAPSPCDLCFVKGLRIQAGVPYFDGPAIVSMSVYESKTSSCNVVNMPRTTSTIPVIITSVPVPTQPPCAGTTYTIQTGDTCHSVSLSQGIGTAWLLMDNRLPAWCDKFPTTGTLCLENKCNVVTVQTNGTCHGIAKAAGITEAQLKAWNVVINAGCYNIEKMVGYQLCISPPGDAYVDPIPPAPVTTPAPLPTDMAEGTNPRCARYYQVQPDEFCNLVVMRFGISLEDFYFLNQGLNSNCTNLFAFESYCVGAFGDIDTYVGRPGSRPTQTESIPFATLTPIASATTTRPIINTPIPLPLAAGTADDCVRYFNGSDFQDASVITGTRWANQCQYAAALFSVSNTDLALWNPSLPNITTSSCVFSSTLQYCGRRYDGNPPDDPVNLGLEFPIRAGAIAACSEYGDVPSDWTCADVLHNFDLSRAQLFEYNPAVGADCSALQTAMAYCIRGPNYSPPAVSSSAPPSSTTSSPGPPGPTHTGQPANCNLWHKVSSGDTCSTVATLYGLTLAQFLALNPAVSSDCSINFWLDQAYCVGTSATSQPPTTTTTTTPSGPPGPTHTGQPSNCNAWRLVQSGDTCSSVASGAGISLSQFLAWNPAVSSDCSTNFWLGQAYCVGVSSSTTATSSTSRPLTSTAATSSTPASPPGPTHTGQPSNCNAWHLVQSGNTCTSVASSHGITLAQFLAWNPAVSADCTANFWLGQAYCVGVAPVVVPEPVQAGNAVAACARYAQAQAGDWCSAFAARNGITDAQLVPIHIQLQPSNFEKNRRRETHRPTKQAPISAIIITMGGGPVTPGELRDILTPSLFSHIVKHRLPYAKDKPINFSHFGRDIFLQNRVGPLVKEQAWPALIALSKIGLDHMPDLSTYLPAPSDPTYPEQVLGLQLLLDHCTRVLFRGVDHRYTNAYFNVLSERLAKTWLSLPADQRPDSWERWHHDLGADLDYWIGVRFWFGTPFVHSELLANQEIALAYTEETRSVVERVSGQTDPYRASRDAILADLHGFPREYRKGPPQGDDVTRESWTFWMGMLMDIHKPIIDRFGRYPSRNAITGRESTAEELTWIEDTGSFGQANEETARKIKEDVKLGRWRPLGEGSEVTATTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYQ1</accession>
    <name>A0AAE0NYQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_107116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYQ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28694" checksum="85D61D4060A558C8" modified="2024-05-29" version="1">METLLRQDIDAVLASLQQPLDSSGCLLTDVGDLLVRVTGLCAQLSDRLVTSELVKRRNAQAAIREVQAMTDCTEFEDVIDYLSKKKRVLEDINGIVKRTKRDIESMWCAAEPPLKALTDSNYADQLLAEIGASAVPSQRDNNAPPLLAALGSPARSATSPQLRGGQHSSRTPLVGATNKAAVFHPSLQARGTGTHKCPHGTSCRKGGVRPNGQVVIFSRNSAFRHHMAKHQKPYQCKLKGCPNTSGFAREDQLRRHEQTVAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ53</accession>
    <name>A0AAE0NZ53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_111046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ53"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24214" checksum="04F9B7640E106A9E" modified="2024-05-29" version="1">MPELSHRMPTAMDEKQRSRSMSPLRRSGPGRGRRALSAVVLFLGFAAIGRFLIWAHAQPTETTVLPMVSEHPLVPLEAHIMSKCPDAKDCLKQLVLPAMQRVYDKVNFTLSFIGTPTDNDGVACKHGPEECLGNIIELCAQKLYPEPKTFLGFTMCLTRDYNLIPQRSLVEDCALEHAIDFRALNDCATKDDGALGMGMLRDSVQRSANVSKHYAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZG0</accession>
    <name>A0AAE0NZG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_519751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZG0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="660" mass="71811" checksum="CB5418C58D5D2371" modified="2024-05-29" version="1">MAEDYNTNDRLDSSSPSSSMPPNGQKKKRTRASKPKVRTGCITWIRRVKCGEEKPACLRCTSTGRTCDGYDKTAVSPRYQPGGGGADLNQSSSSPSMLHGGGMGSHINSNSSSNRSSAELAKVEFVKACQGSEALRSMRPLAPAADMDGAETERRLFHQIRTAAAAGGIGGGGGGGGGLAEHMCTFAGFWSCMSTPDIQQQDDAVKHAVVAVGAAYQLFRNHTFQEPIPDGFTRDGLDVFIIQQYNLSMSKLQRHVSSSSTASVQITLLCCLAFICLESLRANHAVAVTHLVNGLKILESLPSSAFEFLAHDDEGNRPSSSPKSPSTFSMADIIHLFGRLEVSACFFTRGIRPVVAERGYSFRLLDDGSSQGARHFSSLSSLTSAIQLFQRDAMARLHEIATTTNPLFWADPREQQQQACLRSRGTRLGARVDAALPVLLPPVPDTPDLLCTYLDLLFFRCAQIFVFQTPPSSPSTATTTTTINNIEKINIDMLHRDILRLASIIIHASPVAQTLRRSSSTTTTTPAGRRISLLDTGLLGPLYTIAVQTDDPRLRLAAIQLMGEATSSGDNIVERKIARVVFDAANGNTTNSFNNVNNHHQFMMNDEYNDYDDYDYEDDNNNKDLLWPSQEIPRALTGLGCVPRVYDVLVDDPDDVEMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZU2</accession>
    <name>A0AAE0NZU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_539112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042187913" evidence="1">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="41690" checksum="80E12F3EBFD11959" modified="2024-05-29" version="1">MRVASLLCRATALLSAVVQGLALASRNTSVSFRNEAIATRGDRPVVKAPKSGCPPFKKGNFSINAFQLYPENMDWDGNLCQVYIGILFNASFGIYDPYKEALDVVEFPGYTQHREFHVGGVAWDPHSGLASVIVGQGNAFETAGANISGTNLLKKYDPLTRKFLWTVNLTATTQGSYGGFNDAAHDPEGNTYICGTFPSSILKINPQGAKVVPWYLPQATDHTIRGISGIAAHGNTLLGFDSGTGVLYRFDATASTGTAIPVPFTPDQPLTSGDSIRLPIKFKGRVLLIANARGIAVLRSKDASWRTAEFLGVVPNASDLPPGPIIVSSVQIGEKLYIVNDWFADPIVPGTTAGGKTSFPMVEITKQVDDLLLLGLMYLQRVCSFSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3L2</accession>
    <name>A0AAE0P3L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_530126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="547" mass="60457" checksum="0DC38EDAE51123C9" modified="2024-05-29" version="1">MARRYDAVVFDLGDVLFHWDPSVVTALPKTKFRAMMTTTIWSDFDRGFLSAEEAYKLLAKEVNTTPELVREALEQAQKTLYPDPEMTNLILKLGSARMWPGQPRVHVFGLSNITKVHFESTQKAEFPWHLFDRIVTSCGTGMRKPGLGIYQFLLREAGIDPSRTIFLDDKAENVFAARSLGLRGELVGRLGPERSKLVALMTNLLLPNTTAIRAEGFLRSRAGRHFSEMDGGGIINDNFSQLLIYGLTGLEELICLGWPTGSYSPALPPTPPATVHGSIADSDSDGVLTPPISDDERQQATLSNSDLWNYYAAPHPQHATSSFPPDADTTSIAYLSLAEPHLRALPSPALVLNAMLSNINGDGIMQVYFDSSRPRVCPVVCVNMLRLFSMFSTTSIDTSPGLAPTIDFVVSSLANRAYIYGCRYYIPDAFLYFCALLHSECKPTAPVLWQRLDAHMRPTLVEQLGTLAEGDNAMALAMRIRACQVAGVDKAMVMNEFEQLLRLQNAEDGGWPAGCFCKFGKTGKDVGNRGLTTAVVWRVLKEYDGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4M8</accession>
    <name>A0AAE0P4M8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_14676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4M8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042190882" description="Hemerythrin-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="302" mass="33841" checksum="FDFDB34D51D748B6" modified="2024-05-29" version="1">MAGPRTTLILSLPFMIIGFLLSRAPYMMTSIAPSKPWADSPMKLITTPQFLTKKTDIFTSGATHMALLHNSILRGYNSIYQQAPHILEQDKAEFVGYCLTWFKFVKSHHDDEEATLFTKIEELLQDKNVFEETHKEHDAFLAGLFEFEKYLSGLKTPVDYSGDELLRIMGTFQEPFESHFHSEIATISKLSDHPNAPKEGTPQNAAASATFKAWGKATVTKAGVLDVVPFFLLNLDRTAEDGMWTNWPPMPAPIRWGLINIAGALHSGWWKFASCDAAGKPKQLWAFYAADIKAQREGQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P511</accession>
    <name>A0AAE0P511_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_17945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P511"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="84" mass="9207" checksum="4D9567579C32BE4A" modified="2024-05-29" version="1">MLSRRSRPLVLPLSSLRLGPCLLEPGTGGEGPFSLARSERSLQEPRHVLAHLSCSMTSAPRKSISPKNLQCNPHWTAIFETQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P559</accession>
    <name>A0AAE0P559_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_406706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="541"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="693"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="841"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="987"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1659"/>
            <end position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1683" mass="190317" checksum="E5E7114BB6E73C59" modified="2024-05-29" version="1">MAPVLPIKFQELLQLSSLGVNQPAITFNTCTLESDSYICIRDKKDESSSPEVLIVDLKNGNNVIRRPIKADSAIMHWTRQVIALKAASRTLQIFDLEQKQKLKGTAMGEDVAFWKWISETSLGLVTETSVYHWDVFDPTQAAPVKVFDRNANLQGNQIINYRTSADGKWMVVVGISQQQGRVVGAMQLYSRDRGISQAIEGHAAAFGTIRLDGAPEDTKLFTFAVRSAVGAKLHIVEVDHAETNPIFTKKAVDVFFPPEAANDFPVALQVSQKYGIIYLITKYGFIHLYDLETGTCIFMNRISGETIFTACGDKDSSGVVGINRKGQVLFVSADENNIVPYVLESHGTELAIKLASRAGLPGADNLYQQRFEQLFSQGEYQEAAKVAANSPRGFLRTPQTIERFKRLPQQPGQMSNILQYFGLLLDKGALNQHESVELAAPVLAQNRKNLLQKWLGENKLECSEQLGDMVRPHDVPMALAIYLKANVPHKVVAGFAETGQFDQILPYCAQVGHQPDFIQLLNHIIRINPEKAAEFATSLANTEGGSLIDLERVVDIFQSQGMIQQATAFLLDALKDNKPEQGHLQTRLLEMNLRNAPQVADAILGNEMFSYYDKAPIAALCEQAQLYQKALELYEDPAAVKRVVINIAGSPNFNADWLIEYFGRLSVEQSLDCLDAMLKHNIRQNLQSVVQIATKYAELLGPQQLIDLFEKYKTPEGLFHFLGSIVNVSEDPEVVFKYLEASTKMGQIREVERICRDNSVYNPEKVKNFLKEAKLTELLPLMVVCDRFNFVHDLVLYLYQNQHFKSIEIYVQQVNPLRTPGVIGGLLDVDCDENVIKNLLSTVNPASIPIDELVQEVETRNRLKLLLPFLEATLAAGNQQQAVYNALAKIYIDSNNNPEKFLKENDQYDTLTVGKYCEKRDPNLAYIAYRKGQNDLELVNITNENAMYKAQARYLLERADDELWMFVLSENNLHRRSVIDQVISTAVPESTDPANVSKAVACFLSADLPAELIELLEKIVLEPTPFSDNQNLQNLLIFTAAKADKSRVMDYIHRLDNFSSDEIANVCIDVGLYEEAFEVYKKIDNKEAAVKVLVEHVVSIDRAQAYAEEVDIPQVWSKVAKAQLDGLRVSDSIESYIKAEDPKNHQEVIEVAVEAGKNEELIKYLRMARKTLREPAIDTALAFCYARLDLLAELEEFLRATNVANIEESGDKAYAEGLFEAAKIFYTSISNWAKLATTLVHLGDHQAAVDCARKANNIKVWKEVHEACVDKKEFRLAQICGLNLIVDAEQLQALVKQYERNGYFDELISLLEQGLGLERAHMGMFTELGIALSRYHPERLMEHLKLFWSRMNLPKMIRACEEANLWPELVFCYYHYDEFDNAVLSVMERPENSWEHQQFKEITVKVANLEIYYKAINFYLQQHPSLLTDLLQVLTPRIDVNRVVRMFQKSDNLPLIKPFLLNVQPQNKRTVNDAINDLLIEEEDYKTLRDSVENYDNYDPVELASRLEKHDLVFFRQIAASIYRKNKRWEKSINLSKQDKLWKDAIETAAISGKPEVVEELLRYFVDIGNRECYVGMLYACYDLIRPDIVLELSWRNNLHDFTMPYMINLLCQQTKDLAVLKADNEARKAKEKEQEKAEDNTPILGGSRLMITAGPGGPGGMTSPAPYGQTNGFAPQATGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5H2</accession>
    <name>A0AAE0P5H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_531507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24780" checksum="573F4FAF6778BF88" modified="2024-05-29" version="1">MNACDPLSAPGFLICTACDEATISTIENKYGGIHCIVISHPHYYSTHVEWAEAFGCPVYLAAEDKQWLARKSERQGFLTETETSIEVEGVDTEVKAIKLGGHFPGSLVLLFDNHLLIADTLMTTLAGLGNWRANALGEPRDRPADMNSFSFMWSIPNMIPLSADEIASMWAILKHYDFSSTHGAFLGQDVEDANIKARVLRSMQIHIKHMGYAGGREHPLLSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5I2</accession>
    <name>A0AAE0P5I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_27934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042043322" evidence="2">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="158" mass="17407" checksum="07862EC9C1EB2D29" modified="2024-05-29" version="1">MGAEYRMLVSLVLSWLGSAQRRVPDFQGLPAEKSPQKCFQRAIATAKAGTGSLNKSPVSPLCFGVGPAFSQPLAANSQVREASWPVHSKAARKSLGIYLQAGITQPACLERWALHHRFPPTPNFATQKVITSSFREQPEPRTQLNNNIKSNWKSKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5T3</accession>
    <name>A0AAE0P5T3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_459434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5T3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="37180" checksum="C39409A45539C73F" modified="2024-05-29" version="1">MSPPTATARTLATPFSPSDSKSSINTCLADFPASVTSRERTFRPARDVAGYLRAELLAWKIDSITPHLWFAGARHLPARSLHRHRLARREIIITESPSEHLISDYTVVFVKPLPGYLLCYEFWETYLAHDTALHAAACGLVLSYTWLVSYASDFDIAKELRLLPEELSWNDWTSFAGTFLDHVERSSHSPTPLVVSHRYTYGELRMSRVNYLYKFLPSVWDRANPARGFMPTSMWNESFLKRNTTRLLTVFVAFSLILSSMQVGLATPQLQGSGAFVSASYGFAIACLFIELLSGLVVLVVGVWHFRYKILRPWRMRISKQGTQGHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5U1</accession>
    <name>A0AAE0P5U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_517043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5U1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="419" mass="46267" checksum="1057DF9DE35D436D" modified="2024-05-29" version="1">MSPKKIKTTSSSDEFEPSDKQMNSPSDGEGAVSEEAGNAAPTPRRSTRTRGAPTTYNVPDMFPADAPPPQSPSRPKVRYFTIPTKFQKPVREIIGQDEYPRKFAPQEESSPSVNSVHSANDDSSDEGGSRSSPPIKRREPSPPFKEEDDDELLFAGRRKQHTTAGRQPRDPPEGGSRAGGGERRGAPGHSGRASRAPGPDIKRSSTPDVPDSPSPRRYRGPQQPCDVSPSARRGPGASCPGGGPRQVLFITDLPSRTEQGHRQGGQTRPPRLPPLPLLPSAEPSQHSRAGLFATSPSNTRPRSRQVGGPSDLVISRESLRSYRPPPPEEPDSYARVNEDSAREETLREQRQTEARKPTAEPEPEPDSYARIQGNNARERARLEREQEQDQTQCGQRQRERDERQLDTPDKTKREGREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6Y2</accession>
    <name>A0AAE0P6Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_47669</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6Y2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3394498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="494" mass="54664" checksum="954D3DA22DA4CB1A" modified="2024-05-29" version="1">MAVIDDNSFSNLGLGPGAGPSSASSFHEPDNSEYSRPEGSGRGGDDLNHRLEHAAAGHTGEILECIVSEPHKENDGTKDAYVSYMITTNTTFQTFQKPTATVRRRFTDFVFLYKVLCRDYQACAVPPLPDKQRMEYVRGDRFGPDFMARRAYSLQRFLSRTALHPVLRRASIFHTFLESPDWNATMRSRSARGSMAPGSAPDVMVPGAGGSTPGTSGGGGGFIDTFADSFMNAFTKVHKPDRRFIEVKDKSDKLDEDLNHVEKVVARVTRREADLETDLKDLAEQFQRLITLEPGVESAVHAFAASVEDTAAGLKKLKDHTDQDYLGSLRDMTAYSGALKNLLKAREQKQLDYEQLTEYLNKSTAERDSLAGGGGYGYGGGAVSALGGAGGFIRSKLEDVRGVDHEQARRDRQRKLELRIDELTREVEVAHAEADNFADQVVREVESFEWIKRVEFKRQFGGLVDAHIDFYGGVIDIWEGYVLEMEKAGVVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7T0</accession>
    <name>A0AAE0P7T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_533352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="182" mass="20388" checksum="66E530D780E03B52" modified="2024-05-29" version="1">MSSSVSDVACSLVSPSSVGFKKYLIEFRESERKKSRFLEYDAGDLRRDGGASTAIFTTWHISFDHIRSKRRSAADLLSLMSFFDRQGIPRWVLKPSGIAKDPMQARGLDEAGDRVSDESGSTIDGDRDPDDDITGGFEDDVAMLRDYCLIVAEETGETFEMHGLVQLSTRRWLQAFGQLETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P836</accession>
    <name>A0AAE0P836_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_518180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P836"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="811" mass="92140" checksum="4DBB4E54E2A7DFD3" modified="2024-05-29" version="1">MAAPAPADQCIFAKSIERFRASLSEDQKRDFSIANVKDVTREIQKIQNLLGPERKLRNFAKMRKFLEAMKRVEELVNVFLNVSEVVAFVWGPIKLALQVRVISEFFKSQSVSGFFQCGIAKGKTDTLDLILGTYGEIADVIHGVKEYDRLFQHHEEARRVLEICFDDILRFHQAVLEVFARPAWRTFQTRFRPIIDSLQRHRALLEKEKVTAVLGEVQQLSADMTRRLADLKQSIEMGNLKRKEFVLKQKSALAALLGSPDYEEDQDSAASHRISLSSGDWVLREPALDSWLNSDSPTDATLYLNGGPGCGKTTLVSRIIDHARSRQPALAGPIAFFYFTHQDSWKATVVAMLQAVIVQLLHHDDTVLEYLQQKCARMRDPRTEFRTLSVLQGCLKDCLARQRRAWIILDGLVECENRQIGADGLRSFLKWFQQSILTTGTVLGHQKVRFLASGQRDGRIDELEPLKTCSQTRLERAQSHAADIHTYCRDRAAEIRDRFSLDDEVVLDNLLDQGSLTEFENEMGAGNFPDNLDQAYERVVSRVLEKPPLGKRTAAKAILSWVVCAARPPRWREIQSTFCIKAETGICDCKNRRVDSCKVLCGSLIIYLVHTNRINLMEQYTRVALFCCRYLTSRPLQGSAQYNDVQKSALSGYFGLLDYAVACWQHHVEHLAAETPTLPESDRRSIYNAMRLLLDNYGAEPPKENEDTSKDDSPAGDIQALVHAWRTNPTGTLSALQRTEHVRKVIGYHQGGKQVLVFLLSLPELDKLIVEFMKANVSDTTERLRKLLKFATEKKLEDAVVVIRRYLPDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P841</accession>
    <name>A0AAE0P841_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_444880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P841"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="372" mass="39077" checksum="64E15C0EC04BB958" modified="2024-05-29" version="1">MPPRSRLPPTPASSTDIQGEDGSKMATLQLSFELPPPAITPHGSTSGSTASTSSTATSRTTQASETVKTRRRSSAAPMPPKDQFALPPPPTRSRKIIQMRPQPVTETPASKAAPAAAPAATPSTGSKRKQPSATSAAGRKIARKTAHSLIERRRRSKMNDEFAVLKNMIPACSGEMHKLAILQASIEYVRYLEDCVAQLKAQQGPGSGSDVAAFTTSFIAEEGYPEDADSPDVEMTEVPSPELTPQPGRSQQQSISPALLLQDSRNRHGSTSSASTDYQNHHGGYSTSATTSPAFGPQAHGYAQSIHSATSGSNLTSPALPPQRDPDQEATAALLMLNQMDRRGTVASSSSSSSSSSSAPGRGMSVKELLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8D6</accession>
    <name>A0AAE0P8D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_445306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8D6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000123">
        <property type="entry name" value="Pre-mRNA splicing factor (Srp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3395268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="203" mass="24222" checksum="CF42E9839EFCC559" modified="2024-05-29" version="1">MSRGGTTLYVTGFSHGTRARDLAYEFERYGRLVRCDIPAPRSASSRLSSSFAFVEYEDRRDADEAYHDMHNKRMGRDDILKIEWARTPPSASWRFDRTDRDRAPRRSSPRRRTPSPRRSTRDYSPRKDDRDRRDTRDRDYDRDRRDTRDRSRSPVDRERDRDVKDDRGDRDDRDRRENGANGDDRKPIDSPERPTHDDLDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV94</accession>
    <name>A0AAE0TV94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_395848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV94"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="112"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="895" mass="100353" checksum="23996836B6346B50" modified="2024-05-29" version="1">MAQAQQHYVDPLDDEPDEQLICQELPKPEVRAKRGDPHLNRREIKDLWYKAVDQTRKNQSRYVPINEFQYSKLEPGEIRLLSLRPYKRPDDINSPLVARVFTRKLSEVRQRYEALSYCWGDQNVKRTHVINLRNLRPRPVEVERNLKPSVDIFRAAVGHLKSHQFPIYKSLYHALMGLRRMVQPVIIWVDAICIDQSEGGEEEKRQQLQIMDQIYHSAANVCIWLGTGFEGSTDGISLAREMINFQTFDKLIQDGDKEKRWQHLIRLLKSSWFSRRWVIQEAALAREATIHCGADSIHWEDFAEAVSLLMDSIGPLRRSFRDEIFDDVETTSGFVLAATLNSVCRKSDEGDVMAKLCDLETLVSTLLGFQATHPKDAIFSVISLARDPPEPNEKWEKELHADQLRRLSSSQGTRTTNPNQAGDFSMLFKYQLSTRDVFIAFVTRCIYNSKSLDILCRHWAPPVLDKYGLDVAMPSWISPLTRSPFGLAGTFKGRQNGNNFVAYSPSDRRRLYRAAGNSEAVISMVDDWSPVFDSRFPLLLIPTLSINSNSATITGGPVAQSPLPSPSTEKADPSELLPTIPESVPEPQARVLSSNKTPPPPKAKPPRLEFSFPSKDKPDAEAGTGTANSPTPSSTEAANLNAKANAHAIHRRRKSSLLQRKLSQNPDMERTHSLSGILSVRGFIIGRIRTQSEIMRGGIIPGEWVRKLGWTAEDDSNRVPELLWRTIVADRTPTGGIPPLWYKRACLHALVDPRNTDGEGNLHSVTQADRQISEKTTLFLRRVECVVWNRRLFEVEVEELGTTRMTMATGKEGRGGGGGGDLGRGVIKGPLFGVGPSGSEVGHLVCILLGCSVPVVLEPSKREGLFRVAGEAYVHGIMDGEAMGEARILRDFPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVY4</accession>
    <name>A0AAE0TVY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_201792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVY4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="171" mass="18714" checksum="1CD9A0D2A0156843" modified="2024-05-29" version="1">MPKLDFQVYSPFARQSRAFWPAISAVSLPFGAASSLGDMSTTLNQPANLESRTYWFPAGHRLRWLPTPGSSGVLRECQRPEASIQRPQVSSGQDVVADRGLPSFLGSSHGQGAEARGWALHWPESDERQVPTLGSLILPDKKSRCWRRVSSGGLSGSRLGIGPVRSQRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWA6</accession>
    <name>A0AAE0TWA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_217299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041937009" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="577" mass="62308" checksum="3FE77171A647CE40" modified="2024-05-29" version="1">MLNFGVLLAVLAYVAVSARGDGREYGRPQCKAVPGSDLWPSDEAWAVLNASIGGRLILPTPPGAVCHPEQASYNAVECSTVQASWFSETLHTEDPISAIWNNWANDTCLPDPRLPCSSEGYPVYVINATAAQHVKAGIDFARTHNIRLIVKNSGHDYVGRSSAPKSLSIWVHNMKGIERHETGFQPRGCDITISGSAITAAAGTQMLEAYRATALMNQTVVGGNGRTVALGGYITGGGHSILAPHYGMAADQVLEVELVTPAGQIVTANECQNTDLFWAMRGGGGSTFGVLTSITIKTVPSPEIMSLTFQFATAANSPHAFDAITYFLGQFPQLADAGVSGYPIIFKGQSFYTGVIGKVIMLNTRDESVIVSQFEPLFAYINATWPGFVFYTNATYYPSFGAWYEENYDPSPVGYGNVMGSRLLDGPALAANATATKLAFEKFSDGGQATVYIVSGKGVWHAQPRGGGTAANPAWRRTYVHATASVSFAPLNSTAREAATAQTNAFTAALRELSPDTGAYINEADRYEPDWQYAFWGSNYPRLLEIKRTFDPDDVFWCTPCVGNERWQEVDDVLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWF9</accession>
    <name>A0AAE0TWF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_477116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3382011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="66" mass="7160" checksum="DD31292F1B9A3744" modified="2024-05-29" version="1">MPSRGRDRACAGLSFTVGGAFGLFDFSPLNLDLEAKPIRSFPFFFGLYLVFASNSILVRVIPVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZI8</accession>
    <name>A0AAE0TZI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_472709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZI8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3385311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="21077" checksum="82FEF376886879FF" modified="2024-05-29" version="1">MSSPTNSSAVPPNTRAEAASDPSRSWMVGAPVSDARPDESPAPRATPPPTTSQPSGSAPKSVPLKEVVQTIKPADFLAVHTTPCARNGFLTGIGGGAAVGMLRWVMGMPVPRAANWAVGAGAFAAIVQYEWCQSLRRGEQAKMKRIVEVYKGQQNAEKRAAEKRSAEQAEALAKQVMEEQVEARRKSQRSWYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1J3</accession>
    <name>A0AAE0U1J3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_161577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1J3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30606" checksum="36B9E3C18B102808" modified="2024-05-29" version="1">MSFTSAPVTRALVLGLVASSVAASLLDVKHYFYISVGTHILRYRQLWRLLTYQLCYTNSSEVLFAAMALYNMRTIEQLWGSRKYASFLAVTSLFTAIIPPLLLTAVIRPLSFGKFEYLPAGPTPIIFAILAQYHAIIPHTYKYKVALSTSPPTNGDALGVTVSDKSLKYFMVFQLALFQLPGSLLGAMVGWVVGYSWRNELLPGRLTRWRIPGWVVGLRSKKRNGGFEGMRRRLEGESEGSASAGIASGAQPSGNGEGENRRRTMGQQLLDEVRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U2D7</accession>
    <name>A0AAE0U2D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_522062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U2D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3388044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="294" mass="33864" checksum="A8B18C491C6793E7" modified="2024-05-29" version="1">MVDLIGHYEDWDCVITRLAPILTQKTSHSPFVLAAIRQLLERQNIKGAADGEVLKLCESQVKSLISPIDISTLLSQDVPTAAPSAKRLGDKNSMHVQNHHGKAPPNQFKIVEQVNNYHPANLQLWLQFLRSLAYSLTYRNVPLSTPRYQQIAIAIFDAYLDNYIGKEPPNSATRKARFRMSETRREHLQLILRRSKSDCRHWTERSRSPHVLVVLKNNEKMEREINAWADRFHVARQEMERFNPQELRSLLGENYENITRTSRLRRAVVTQPVTGLKRKAEEGINVDASNRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3A9</accession>
    <name>A0AAE0U3A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_537092</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3A9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3389286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="247" mass="28493" checksum="F44D0446888CBC08" modified="2024-05-29" version="1">MVWFFDLIYDAMLSLGLVKKKAKLLFLGLDNAGKSTLLFRLTNNKLGLLPPTLHPISEELIIGNVHCRTFDLGGHKQARRLWKDYFPEGELNALLSMEELWGVPFLILGNKIDHPDAVSEDVLRRVLGLNRPVMRMSSLAPVKGLLQFIGELYKFGMLTERIMRECVRKLLEYQSLQLPLRDKSTWGRFLKYLDGDRRPHSDSGKIEIFRMLIDAGIDFDIPWADDRSTFWNEITRILPEAKALRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3R9</accession>
    <name>A0AAE0U3R9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3R9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="108" mass="11498" checksum="DE88D7B39EAD36A2" modified="2024-05-29" version="1">MALSLLGGLQLAGGVKLMMSGKAQVTATKSEKVIALSLLGDLQETGKKAKVIMSYGMYDSLAFKGRWSVLAVSDGHENAQDTSIDQAEGATRPFARNVTKPSLHLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4M1</accession>
    <name>A0AAE0U4M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_121170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4M1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="391" mass="43579" checksum="29C75BACD0C639E9" modified="2024-05-29" version="1">MGSRPDMDYGSTKNELHKRNVEVVTVPIKDIGSLRRAGLRLASWIFGSPLTWAMHWAIRVDGTYFELHRPGGMAKPCLRTSIWSEEKERGIIATVPIGSTTLSDDEIVAASEPYFTERTRLMWYNIYINNCQLFVQFSLERICPVTQSLNPVPPALHNTVSLVLSMAIHTFSLPPILLYIQWLRWRGCDQRSLQAYAALYTSATGLAVPMAIILLIQNYNHLKSVFEAESLFIAAYATFVTSIMVSGLFLIQPRLSFPVAKQRKNGNWEVSTIQKQNSEENVDPEVKIKVTHLWISAIIGASIGVVLWVIVATPYITRRSAAFLSGRLAFRSPLAFGVSVWELLTMPIFELDNSKAVENDNDTTGSEGLKTVMNADYGEGAVMSRSTTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4W1</accession>
    <name>A0AAE0U4W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_519773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="40691" checksum="6182B75D29440B0F" modified="2024-05-29" version="1">MATADLIAAPSTGAVAGAEEQLPVRTNTTNQSVAQQEQQQQQNDGPAPFDIVRTYRAMLASDPDLTMPMAAIESLIEVLHATPSSTAMETVEVVKKEKAKLIASSPNPLPILAGADLFEQFLLRSLRGQTAAGTSGGSTDRVLSFEETREHLLHNQQLFARRAKEARDSIAVWGSKRVVDGRVVLTVGGSRVVNKILLHAAATNPGKYFKVIYVLDGSPRSASSVAALREAGIEVETISPAKVAYVLSNQSQINVVLVGTEVVMLNGGVISRMGTCQLAYLTKQVPGSLKRFYVAAETHKIVRKTPLADPMVIQLGVNQKDISKFANLGIDSSSINDDVLAEENEVDYTKPELIDGIITEQGIKTPDQIWQLTEDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U538</accession>
    <name>A0AAE0U538_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_390734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U538"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="581" mass="63103" checksum="B351A7B841A601EF" modified="2024-05-29" version="1">MAAVKKTSGGNNAYHNFHNDVVHIKDPNERRRLALAEVDRAPFGWYHVRAVVVSGIGFFTDSYDIFCVSLLTTMLGIVYYPGVGVMPHASDTTIKLATSAGTVIGQLGFGALADIVGRKKMYGLELLVIIFATFAQALTSSSPSMDIVGLIIFWRVLMGVGIGGDYPLSSVITAEFATTKWRGAMMGAVFAMQGFGQLAAALVMLFLTLGFKESLETSTKLANCTGNCALSVDKMWRILIGFGAVPGCIALYYRLTIPETPRYTFDVEMDIEQGQDDVKAYIEGKAGGHPDEIARIATQHKAEEELEVPKASWKDFFRHYAIRKNAMLLAGTALSWCFLDIAYYGVSLNNATILDVIGYSTKNAKSTYEILYNTAIGNMIIVLAGAVPGYWVTVFTVDTIGRKPIQYMGFTILTLLFVVMGFAYDHLPPNALLAIFVLAQFFFNFGPNATTFIVPGECFPTRYRSTSHGISAASGKIGSIIGQGAIAPLRTRGATATNPNPWMANVLKIYALFMLLGIGSTAMIVETKRKTLEQLAGEDDYAVEYASAGQEEKKTQQQQQEEEGVLGKRIDTIAGPSSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6Q5</accession>
    <name>A0AAE0U6Q5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_516202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="294" mass="32956" checksum="4AE53490C4FA9ABF" modified="2024-05-29" version="1">MSLTMTTEPPKFSPTEEPLDRVGINMVIRQDPFCITLDAAALLAVSILLVVGMHFMELFVLEVMIILVPIMLLVHNDYLNFLKLGPGGTPPTPRGYARLTWYRLFTLRDCFTPPPRDASQIPTAGILTQRPLPYRPGPRPNVAGLAPQRQLNQHGSLHAYNRLRAALEALSARTPQKFVTATSCLEKHGFALFARHPLNVCGNGEICHLHTSDRSMHMNLHPDDIKEVLEKGWGQRHPLAFGKGWIQHGPVPTTFTMIYAPRDESDMRITCRIIEAAIWYTTAEQVEIPPGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6W5</accession>
    <name>A0AAE0U6W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_516415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="19142" checksum="B786078BCA7F3131" modified="2024-05-29" version="1">MSFFSGTARIGHSSKLPAGATREHGIAMLRDHEFFIRCDPHLNKLEVVKTDTPPGIPDAIKSQACGETHSYLVTDRVHTLPAGIWDSNIASTWETTDITNGIFVRIKGPMSIVMDTIWEIRAGEDGALELAEEVTITCSRLLLGIVKSECEGGWDKIHAKMIARVEESIKNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6Z2</accession>
    <name>A0AAE0U6Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_498380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6Z2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="200"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3392920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="422" mass="45634" checksum="736C49BC59B8EB13" modified="2024-05-29" version="1">MASSCTPIALAEAAAQPDQAAAYKTILSNIKSLSTPGTAAADLTAISDAILTASLGVVATRSVLADLITALKALGNHHDMWIEVGTHTVSTISSNSSLSSSLLEQCAALRDLVATAHEANEEFLDAAKTLAEIPLDSSQRRVGDAEKVGIWIRIVRNYLEVDDSTSAETYLNKLKNVMHTIDDRDLQLHFKLSAARIQDSKRQFLAAAQSYHDISFSPAIAEEERLHTLSMAIKCAILAPAGPPRSRVLGRLYKDERSAGLDEFGILEKMFLDRLLAPAEVDKFAQGLAPHQLATTSDGSTVLAKAMVEHNLLGVSRLYKNIGFDALGMWLGLSGDKAEDTTAKMIEQGRLSGSIDQIERIIWFEGGDASGEKGSGRVEVLAGKEMRRWDSNVQALAEDVERLADSLQTEFPAFVADHHNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U701</accession>
    <name>A0AAE0U701_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_13266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U701"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000025">
        <property type="entry name" value="Exosome complex component rrp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="52"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="361" mass="39581" checksum="00623760DB638CE2" modified="2024-05-29" version="1">MAAAAPPSLSFPRPVFAKLSPHPYLLRTLAPQVSPDTPTPKPSRTNGRAPHEARPVYIHTSSLSHAHGSALVRVGDTTVICGVRGEILPVTSIPQYRPRADFGEDDDEETRRAGRGELKDYDLLVPNIELATGCAPQFLPGVPPSTLAQTISTRVYSLLHSCAVVDAKNLRIWASPVVTKPTGCDDDADKMEEDDEEEEEKPELVAYWVLYVDILVVSFDGNPFDAAWMAVLAALRDTKLPVVTWDSDRGVAFCSRNAEKRKLQIKGLPVACTAAVFLEKEHGSETSGEENNRHWILLDPDRSEETLCGETITMVVDCEGGETRLRSLEKQGGTVIGRELIRGFAGVAEKRWREVKGAMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U726</accession>
    <name>A0AAE0U726_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_16950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U726"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="662" mass="72315" checksum="BF3E65B14548459E" modified="2024-05-29" version="1">MSRALPIKAKSCHDRVLESSAFLSSSYLSSSPIIAQEILARDLAQCLDDTDGEDVGAEEDVISEFDDGLGTHGALLISRPAGIAYGTLRPILAADAPPGTPALTGLKDIVESRNAERSLLRDNHILPPKHARPFDESVWKRLYRRLFSTKVPVPSTDDAFGPPLSRVSTKALESTPLLPHEYLEPHTPTESETQERWDAAVAANILKTTWQREAKTLTQYSRALIVTFLLHYSVTVTSVFTVGRIGRMELGAVSLATMTANITCYAPVQGLSTCLDTLCAQAYGSGHKKLVGLQLQRMTYLLWLLLVPIGMLWWFSGRVLGTIIPDPDTAALAGMYLRVLILGTPGVAAFESGKRFVQAQGLFHATTFVLLIGAPLNILANWFFVWKMGWGFTGAASAVVFTQNLLPFLLFLYVRFIDGMGCWNGLSWRAFSNWGPMVKLALPGMIMVEAQYFAFEVLTLAACQFGSAHLAAQSVVVTITSTAFNIPFPLSIAASTRVANLIGARLSDAARTSAKVALVAGCLVGLFNMTLLSSLRFKLPFLFTKDEEVAGIVSDVLPICAVLQIFDSLAAISHGLLRGIGRQAIGGYTNLFSYYLVALPVSFATGWRLGWKLEGLWFGVTIGLVVVSSVELWYLHHADWQQAVDEAESRMRSDEGQRIEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U756</accession>
    <name>A0AAE0U756_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_516278</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U756"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041955217" description="C2H2-type domain-containing protein" evidence="13">
        <location>
            <begin position="31"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="459" mass="47210" checksum="28C510D08BCD500D" modified="2024-05-29" version="1">MTSPNTSRPRGPPFLSSSSLLLTTTAPASASLTSSSQTAPSSQSTTTTTAAGTSILTPSSGIASDGISPSSGVNSGSSQSSQPYYPTQVTASWSTPGAQHSAYTYQNSSPYHQRPGHYGTISPSMPHHYGGRSSASPANGENLPAPPPYQDQPPFSTPIGSGGGGGGGGAGGVTLGSSLTSQQSSGGQQQSGLAPPTLSSQAPAGTQPPTPGQATPATTQESGGYRQPPTPSSFYPPSSTPQTSSYSSFPGPPPQQSPSAPSPTTSGANIRALANMSTSGMAHPMGGYHPARHHMHPRAASYAPYGQIPGPVLSNVHQPGAPLAMVGGMPGLQGYAHHHHPGMSHQHHMYSSHGAGGPPPQERPYKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCSHCEKSFSRKDALKRHRLVKGCGGKDSSGETRESISAGNEGSPHGSRSDMVSDEDGSPRAVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7E3</accession>
    <name>A0AAE0U7E3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_505570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7E3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042285366" evidence="17">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3393728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="213" mass="21239" checksum="FE0EDB02A4CD3E99" modified="2024-05-29" version="1">MKLSFINIVAGTLLVASGAQSQLTGCAAVAVSVIPSCAQTCFLEGAPTIGCSSFDFACQCQQEAALYAAIEGCVASSCPDSESQNVIDGAAKVCECAMGGPSSNAGSQTVSGTLVPPSSFVPSFTGSFVSSFTGSFVLTNSRSFIQVPSTATATETAVPVSEDENGAGSGSPTTASPSYYATSKVISAASPQSRLGLGFIFSVCGVAFALVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7H5</accession>
    <name>A0AAE0U7H5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_444055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7H5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="255" mass="29004" checksum="AE17A70F0241E9BA" modified="2024-05-29" version="1">MARTYRILHRVWRAKRPLYWGMLPELAGTIAMLVLFGLQQPDLYRSKFWQIGFNNQLNSNPAMVLYAYANYEPLPSIPLVWSQTLTNFNVAISIVSLFILLGKMIAVIMKVFYPIIGLFTNLSLTALYAVSVYGQAGPDYADPRYPSSVAWYIRMGCDIAKPYNMVKQCQMAKGTFAATIFMMTLYLCNLGLAAWSMLPNPENDFDDDSDDDNVGGKQWEMQPQPPMTPRTVPFTPRTLAFNTLDRKLPLRHGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7T1</accession>
    <name>A0AAE0U7T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7T1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="643" mass="71959" checksum="8786E94D3C9B7359" modified="2024-05-29" version="1">MSSEVPRGLGLPPKQLGEAGDVDRHVRHHGGRRQSATRRITSNVSSFNRNRDHRIRRSVPYPEPQTPRTRSMARRAAEAEAEAESLAMGEQRVVSIPESAEHEHQHKRNAPSEEWKPSITIGDSLWLPGEDLSRIEIAERRITQCRAWLQYYGATADFPQLLEEAISERNNLDEKDENNTMPVSRLPSTHAEAIAQRLDVLRSAMEDSVFPPERANIGAAIAGYESGAIPVSDSYTLVWGGRIVDRCPDYDTFTRDRTVRLDRYFTQYGEGWLWFEPPLTGDGVGVPSPIVTAKRGTCSENLPAYRKAMANIGHYQTTQGFRRRKEKVTRRWPLFSGISGKRHDSKTTDPDPDGPRMLWKVLLDSGATLPCIFKADLVKLGIDVTRYARQSQVHIATANGKCWNPVYDLDVGLYAGEEKGLALTTSSEAHPPNMRSEPNMMGCTMLPVVVFDGACKTDKYPDSPPERLSGFFPFQHLYISSAPGNFRLWLGEDRHDVVGTAQMPAHMRTKAPEEEDGTYNRKSKADVALPDRPAWLERVLPLLGPPTRTMFEHVIEDGSGQVLREEDNGRRSYFFQAPGGTDLDNIHPDLRIPTGLQVCNVGPKTKLSQRGVGEDEKTLGRKQPKKRLGQRLASKVTIGSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U800</accession>
    <name>A0AAE0U800_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_555599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U800"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="231" mass="24534" checksum="39325F7B5C3081C0" modified="2024-05-29" version="1">MICRTNLFRQATQLSSSSRQPIAAVLTSSSSSTITPRAGAAFFTTSTSKHNAAPTAPLEAAKAADVPDLTPLTTGSIETTSETGNLSSCVAGTVLNGLNYTKGKTDPVALEDSEYPSWLWDCLSVQKKVASAADAEAGDEFSKSKKQRRLAIRRQRAEEAKMLQSGNLEALAPKVPLGKQSINLAGGSSEEGGGGGLKEAVFAAEKREELRKALRKDRKAKIKESNFLKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U861</accession>
    <name>A0AAE0U861_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAFII55 protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_460749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U861"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="296"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="661" mass="72007" checksum="46B6161EA8B95E4F" modified="2024-05-29" version="1">MVGLTYIWPAPSKSSRTAWSQVNPRIRAANRAAECAGATYRALRTSLIFPPIIYFVSYSNRMEQKPPPPPPKRLTLKLSSQNKAGGGTPSATSSPSFSYPSAASPPPLTPGGGQHKIKINLSKRSQPPTPAEKPATPSIIGRSSAAQNMSSASTPEPTPEKIAYDYGSDDGRTGIPKITKTKPPNQLLKQAGRKRTKDESDADEEPRIPIPSANARKPLPSSGLSARTPLPSAGSQEPALKRTKITLKGVGGSSERVAPRGNKTLVKVKRSGAIPQRTLGEGYDSEASDREPDPVDERQFILRLMPGDDCDALRKAINERRVGIHKSAGGFDMQMKFLEESGRRMLVTIQGQPYAAILLDLPTITETMKTWDKKNMVKSADVCQMALVFAKVSSEEEARTVPLPKAVEHGHRWPHGITPPMHDARNRRFRKRLSKLQIQNKEAEVERLMAADEKAKSSRYEYLVEDSKMNGDGFAEGDEDEGADADGDGEADDYFGDAGVEEEYDENLYDEEALEAAFFQTDTDPLETPVEQPKDLATPAVEGVDAITPITANTGTPAAQTEESGAEADGANEEESEEDEEDEGDDGEMDDDDDDDDDRHDNVAGIRAQITDLRKRLAGFQSQLAGAVGKIMRNRLEANIKNIRSEITLKLSAIGETEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U885</accession>
    <name>A0AAE0U885_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_46132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U885"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="577"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="734"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="870"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130960" checksum="36008914879C0CD5" modified="2024-05-29" version="1">MENDPPPTSVQDDGRGSKRGRIMGKLFGRDRDRERKIAQDDGPNSGDLNDFLRGSSDTLQVAHAEPPPRLAKLDIRSATRYPNALHVDAPGDLQQDPAYRPRSHSPRNRIRKKGLVVRFVDTYPDIIGDGGDECEVPTFEISRRHKPTRPPVVTAATAPARPTITGDSSQTRMPDPRTNDGPFAPGPLRRTQTGYSTISDTPEPAIPVERSTSARYLEAMNDVNDERRRSFIEVHQAEMREAEGLAFAQAVRSGSTSEDSSRNLAIMPSPPTPESAVEGVFTDLPRPGKSTQDRPLPPKPPSRATASVSPQPQFAQPGLAIRPPIQFRDSFQNSQRSPVPPPTQERQLHPSQDHKLQTSQSTDSPERLKRTPVIEQQSPSSTYSTSSSNFNHPYGVLKQGSRNLERSNGSPTSSPRVSSNLHDVVVAAADDAMDAFVARTRHLFELFRLYSETVRPLAACSLHELGRASLWWFLIGRMALEVTIREQPTTPEAQKSNDLAKDQAYADLAKAYWLSEIIVPEISGNKRIPIDADIEESRYALTSNLRKLAVSMKRNGFLPPEEAVLPQAINRSIWIEYPQITHDIKSLLWGSSSSTLAQTQPTAPGMSISEALPLADSAFSFCFGRFTTDVILTEQGRDSQRLYFPCILSITRPQKQPDIVFVVASQDGTIQLRISGNKNLGPIWDDVRWRSDTCTLDVRLPRGLILVVQCSPQNYKMIWNMYEFSAKVNSSLYPRQDEQCIFRSTLRTFQYFDNDPQARQFPREPTPNCDIALFERVSREGAAAGPRNHHRGYRIAVVTGPKTKTLSGVSQTYTPQAPIQFGFLRSEANDPALSLKFESGRLKGNMVLSFGDEQERLRMHDLLIGTALRRDEQVYCEVPLQGVWFSERFGDANQKGLKVISALPWQKLRAINHENDGDRPSCILSDKLRVIFEFKDGTFTDRINVTPGELKLRLDVHNPSCMMIFRQAQDDATLACTEAKFSRDLCEGLREGLETLQQSATIRTLMFASVADLHAFQTAITGYKVLFDGIASAFAISRRRMVVPIHKKWEAGATRVQVVQQDGVTQMLAFFDEFSHGKCLGFSLKGTDVFESFSRGGKAGLKIDDAKFPLPKVLPTEDGSALGAAESAFLCLDLPELPGEHDDITILFDNETEQQKLISCLPAPVKGSRLSKIKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8I8</accession>
    <name>A0AAE0U8I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_462429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8I8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF288">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="156"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="427" mass="48110" checksum="1246D027BF30EE08" modified="2024-05-29" version="1">MGAIATVAIIVLGISFMTFVAFFGRLPALRRTPIAWLHRLIWVHIPNSVLALDDRLTAGKVTSSCSRFGNYIMHDKHPTVLIFFLLLLSVGEFLYLPTAWPQLSRYQQFIGFIAMVLPYLFLYLSAFSDPGTITARNHGAEMARYPYDFTLFHPGASCSTCRLLKPARSKHCSICKRCVARSDHHCIFINNCVGAGNTHWFVLLLLSTAFLTLYGGILGLQLITAKMRARYPFWAVIPSRAHDGAGMDFADWLIVWSYGLQAQGGVSMGAVTLLALLTSPLVWGLLGYHLYLIYCGTTTNESMKWSDWQAEMSDGFAFRRALVPPRPAVRAKDLSIEPLWTRWPAEAEQILVRTENGLPPVQSTSLPGVGEWEHVWRLKDIENLYDLGFWDNLVDVFVPYHMFRDPPVGRWGSGHTEEKQESSDDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8X8</accession>
    <name>A0AAE0U8X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_533776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="51961" checksum="2D1AFAF332C329FA" modified="2024-05-29" version="1">MAAFNLNLQPMVGVNWAGLRDQEFIDTAKECRDKFLRYRRGQSWEAHLRRGIISHYKVPRSGRYRGPRIEKNMETDPDAAFGERYGGGVGVKGSSAYRGSVQDVAKNVANFVRRYGLQFNKILGWGTYGVACLFDQRNMQDVVQSRYVIKYTTQPFMDLKSERIKMRRLNRAQHVVRHLDNTQTINTLRLPELLSYPKRLRRAFLDIFLSLQRRRQADPTPAQNDEIFDNLLFLEYCPRGNLDQVIHKSAKGRYPRQRRPFTERVLWHLFDCPIKGCIGMQLPRQGPPVMERVPSMWPLTSSDPNVINEHQLHLVHFDIDPCNTVIGREGLAHNNADDPHDVVPPFHLNDFGTARYWRQQEGDDLQDLWNCRYTAKKGFFTPEQFTEGWDFVTTCRTTTHGPSWPAGMDQSPTPTSGTVTTCSGTTTSTCAILWLAASPTTLQTGPTSPPWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U968</accession>
    <name>A0AAE0U968_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_64529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U968"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="278"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3395139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="706" mass="79404" checksum="3082907A4D1CA4C1" modified="2024-05-29" version="1">MLKPTCSNCQQYGASCKTTAVRRRVGVAHARKNSASQATASQAIPEANRIDSLEARLARIEGQLQQVIDAASAAISKASGGQSTVAEHNPPVSIQSEHRDMSGGEEMDAWLQLDNGGFLPAVSTDPSPASALMTDDDIEYLDSSDWVVPERPSIPKLPPLEQIQPIIEGYFRHINSAIPLFSESAFVRKLNEWYTFPSRRTRAVWAAVNIVLALGSKVLTNPTLDVDFRVEDTNLSVYINNAQSVLAELVTREEDLLGLQVMLGLVMLMRSSKDPRPAVVLVGAALRLAHRLRFQSRYELETRYTPDEGLHRCRLFWITYMLDKEISLKHQTPSVQLDTDIDLDLPSPNPSDGAGDVYTADGRVRFNYLRARVQLAYIQGKVYDLLYSTRSQKVPPQERRARVVRLATQLEKWRRTLPPEMQLGSVERELDRWPLAHMSNLLWSYQACLIMTHGVWSHNAHWLKRVSDYSRIAILDSNVDGPKSCNLQQPPLPVAWDCCLEISRKCLAMARVMPQSDWDVWSNTCAVFSALVILLANMYEHPDLTVWETDKKLVTYSLDVFHKIKNISVLVPLHRLHVVVVELNRGAQLALELAERSRLELAEEMRLAETENLKENETNETPEVRSDESSWTMTSGDNGLPVDALPHVMMDWDLLAGASAEWERVGGNYFTNAPATREAFNFGEEMGPFVDWTNVEGQQPNFGSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JY59</accession>
    <name>A0AAE0JY59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_456193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JY59"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="161" mass="17968" checksum="A07BB6B38F02A36A" modified="2024-05-29" version="1">MAVTAMVAREKVVAVADLASLSSFARNFSEGVARVHREKLLFEMLPDSFQRQLQKILGGSPFDSKFGREAGGARHGFANNIKSKLLDKIRSLVRKWYETLRGSILGVVNGGHRKFERKSWVSMHYMVEQEVQTYSPNVKISVPDDIGNEGVNICDKASDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K143</accession>
    <name>A0AAE0K143_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_69223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K143"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="206" mass="23020" checksum="20B561D9D2374B69" modified="2024-05-29" version="1">MCDYGPAELALLAKTRWSRFASRDQHLPFSFFGAFLGGFTERVLGLAHSHLRPSLPLGFLKEPRFSRRSRPDCYLRTHTHHLANDGPVPTTALPSKIFLTNLAFGGSPPHTLSGSGQLRGYLPSLRIPNLSNLPSSQHLPTSRPLPQPKGLSRCLGPPHTQNFPLWLKFLFYQNGSRLDSKRTRAHLPLGGQFETCMPKLFDPNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1G5</accession>
    <name>A0AAE0K1G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_74656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1G5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="878" mass="91528" checksum="535CC71DBC0A5746" modified="2024-05-29" version="1">MGSRPGNNRAARGSNQPTAPRSSAAAGVDPKPNLVASTGRPSTSASGTKGGETPAARANGGGSKNIPGSPQKPSPDPGSASTQGLTKEATGAIVNLQSALRESQSSPGEGAKMARLVAAAASVTKAAGSTQVATTQATGVSLSAQTLNRTETGKSDHQHAECAPDTSRGPEGQPKTSLNSQKVSGHAVATSKVATPPQTPPGPLAGKREESDHNGHLTVPAGDDGAPASDPVTSAEEATSPQTLSRSPQAGIAQAAAPEPASPARREEGPTTRTKPDAASAGAADSSLPNPPRSPQASNAQTIAPTPASSARREGGSTTYQTETIPGAAGPGTANLCPPSPPRTPTPSPPTNKGLEAPGPQRSYTLPTPRSLPAEDDAARVAFQRRLETPESSLAAAAARTGERTTQAPIAALETIIQARFAELDTILELRLKALETAMPWADAREGVLQRLGDMENELARAARRESRLQDRVKVLERKVALLEASAIPSAPSGNKDEDEEEEEQETGREGPGLGIAPVTVPSPSPPGQDAVPGGGGDNGPVEPTEDPGTGRNHPLVMGRGGPLVSECETSDGGGADLGGNNVDGGDDGNGERRRDGGDSGEGEEASFGDLQDGLLADTEMPDGELGRAFLELETHIRALVMDHFRFGVDEDTAAKVAVKRWNANAFPSEAWGNAKLKKSTWFHRLVANLLHAELFAAPFFGCQETSVEKGLVGFEQLVLGQGEYPGHQEDLAWWRALTMKIIGGLSPPSQPERRDPDTCQRLAEVIKTEFSPIFKLSKKADKKLLQVCRKAVECATATRKSRSTYLWEQTRLVVEVDGKEFGIIGARLGEKDTLGANQVYEVVFSVSGPVVKEYEVAERGEIVRGRTNILRGLAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1J7</accession>
    <name>A0AAE0K1J7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1J7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="12684" checksum="A0F6CB818412A016" modified="2024-05-29" version="1">MTLKGPKLDTERELTAAFKTLKQKNLDLVFIILDLYSTSLYKVIKKLGDVDIGLCIVQSKFKNKRDLNQQQYFDNVLLKVNLKMGGENQCIDFETSLIPNHTEQWSSAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K203</accession>
    <name>A0AAE0K203_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_487699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K203"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="32742" checksum="06C8F04D18A8FA4C" modified="2024-05-29" version="1">MVPPPTLTAGGLPTMAKQTPTKTMSSRLMTMKFMQRGAAAAATASSPATPNTDDEAGATKRRKTTYTSAPNTPVVPLYDTKAVQAALEEEDKKRKAAIEKRAAELGDSHWVLTGVGTVPKSGPRQLLNVVQVGFAQIDYPTTPGDSAEEEASSHEAVNGGWSAGGRFRRFNMKKPKASEAKKSNTDSEGSEASDSEDESSDEEEYNGTPSQQSDRGRNRNSERGIPSNKRSFSSVSGARREERKKPQELAGKRRKKDVNLNQLTSISAAGTQAKTAFQQRSASGGMACYGCGKPGHKASECPKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K247</accession>
    <name>A0AAE0K247_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_490125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K247"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="352" mass="38349" checksum="476313D45CDD2C44" modified="2024-05-29" version="1">MLATHHPSSVTLQSSTQPEISPLFFIMAAPKILIFGPTGNVGSWVARTAQAQGAKVYFAMRDTTKTIPSISPEEEKKGGYERVQADLSQPETLHKAVKSTGATRAFIYLIHSSTDGMRSAITALKEAGITFIVFLSSYAVQEEKRAVGTKNWISWAHAQVEISLEDVFGPSHYVALRPAYFATNSLAWVPQIKSGNTKLRIPVPESKFDWIAPEDMGRVAASILVRGSLTTASGEPDTDAEDPKGTYIYLMGPQILAQADALKVIGRAIGKEFSVEALSDEEAFQYFVDNFHVNADGAKGLVNTLKDTASGAVKEFSSDPMYEKRAANTLKYSGVEPTPFEKWVGENKSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K285</accession>
    <name>A0AAE0K285_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_441916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K285"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="449"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="662" mass="75424" checksum="4B6DBB069BF242A5" modified="2024-05-29" version="1">MADIAAISEGVEAVSVSSPVQALYRHDCVYASCKTRWSEFADIDQEQSKVEEKLKEQPIVHRHTYDAEKLKWVTAEFTINSPAMRELLSEALDNYQDLDLDLESWTFTPPYRPIVHRWEKLKALHKAASELTDNSARKQAADELMAFLSPLLAPWIEALAKTQETQKVTHEMVWQIFAPGELVVAKFYGIETLCRVVRYKIKKTSCYITVEYVDWDGDRCGLASRLINIEYFASTRSVSSLPVYPLAFTSNPDEMKEKMLKRGREFEKLRGYHFLSCSGTMILMNNEERPVNGRVVIDTYAYYQSNNILKPNLQSLSGETEAKPAKEKTEDIPEEEEEEDTASDTSSIIDIQDEMVSITQPVNVQRNEDLTPLSDGHCLLATPWVIGMDLKTKEWSRFKIDDLKEIEWNNKAYENLVLPEGEKELAWEFVESKGAETEVYDDFVAEKGRGIIILMFGPPGVGKTFTAEAVAERARVPLYSMSAGVLGTQPYEVEAALTHALDLCRMWKAMLLLDEADVFLGARTDEGLARNELVSIFLTKLEYYQGILFLTTNRFASIDHAFQSRVDLFLPYRALTSSARRQVWDNFFNHHGRARFSVDEEELDKLSELKLNGREIKNLIKSAQLLSIKANGKVTYDRLYSLAEKRVAALKLLAEQGDDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2H5</accession>
    <name>A0AAE0K2H5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2H5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042224634" evidence="1">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="233" mass="23945" checksum="38507A1E5983EC9D" modified="2024-05-29" version="1">MHPKFVIATVMALAFGQLHAQAPSRRARAGGSGFGLFAYGGTIGGLPVFFSDGTAVITDFKTANNTGSNLVPVAFSSGSDGGAFSAAPNTTAPVFNNATETPPFSNATFFVPGEGSSSHQVGFSSDITSTDIITTGWTFYGHIALLEAAGGSLISLFWAVPSGTEGVWNLTWNETDASSGAIPVTLKDTPPPNLVVKVATALSKKQSLVKKDGAISKMSKSMAGEDDGDEVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K584</accession>
    <name>A0AAE0K584_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K584"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="390" mass="41166" checksum="5A3482DE2ED12F54" modified="2024-05-29" version="1">MASTPRTTKAWTYTRTGPPRQVLSLTTTHPFPIFPPPNPSDEEWLLIRVSYAALNPGDGIIMAVLPFAFRSTKTAVPGYDLTGTVVDVWTAASSSSTPTSASPEATQSRFQKGDAVIAFIVVSHMLRTGAGALQGTVAIPAKYVVKIPAHNTRREAAGLLLTACTAAEVVKNASLKRGDKVLVVGASGGIGSAAVQLVRDAVGADDHGDGGGRVVAVCSGRNEAMVKGLGAGEVIDYTLYANLPNELARLHGHSSKPFDAIVDTFGDQNLYKHSSQYLKPDGIYSAAGIHSTGYSTWPILKAGIAMTANALWPRSPWLGGSGRTWIAASMMDPGLELMESLVALLGQGKLRVAVDSVWSFEQVHEAFDVQLSGRARGKVIVKVNGDEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5G3</accession>
    <name>A0AAE0K5G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_552379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5G3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3370416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20798" checksum="27D0498E4A316D90" modified="2024-05-29" version="1">MNRPTKDAGFLSPAHSEEEYGSAAAPTGDPNRDASATHAKVPAKGKLTKKDAQAIKEVYRYQMSTHLLLRKQPFQEVIEDILENGYPEDITMDKEAARDLQEAAEAYLVDLFKASQDLADFREADNLETKDMRKALELGLPWGHSFNKMKNEEESETEDDGGSEGGDKDEEEEEEDSNASDKENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5R0</accession>
    <name>A0AAE0K5R0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_487266</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5R0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042296586" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3370583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="50103" checksum="10407F34E4711391" modified="2024-05-29" version="1">MSFDVGQLPLCAVSCLAIAVSRSACAIGNQTCICTDQTLAEESRDCMIQNCTIREALETQKLASTSCGIVPHVDHSYQAIFIVFAIISAIMVCLRFFARFLIRFKLWWDDLFSFVALLCCVAFAVLGLYQQGLGFGTDVWAIPIDNITPLFKGYYAAFIIYGFARFFIRLSITMFYLRIFTLPRARPIITATLVAGVALVIAINGALAFMCTPVDHFWLQWDGEHPGSCIDSSKVIWTSSVLHIVFDLWIIILPVPFIRRLELSRKKKASILIMFSVGIAVIVASIGRLTAIIDFSFAPRSNPTIDAVPLAVWSGAEMNLGVICACLPSLRVLFKPFWNRRRLNATPMSGGDKNNSNYGPIMIPSESPKTSARSFPRHDLAAECDGSTWSPLQDNNNLHSPRCLESPSAIRKTVTIHQIEGKTIPELCFALSELPAPGATRQGVVRAQAWAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5R4</accession>
    <name>A0AAE0K5R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5R4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042060590" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="17267" checksum="81E3558AF04DC364" modified="2024-05-29" version="1">MRPLSILTLMGTLLLGRAAYAAVEAVPAPPGVQFLFSANITVGLPVDVGAIPAGNVTVIPVIGGAVSGPKIAGKMLALGADWNMQTSTGYSFSDMRAHIRAMDNSNIYFQMSGVNQGADGVSFVGGSFQTGSKDFWWMNYAFAFGVMKPSSTGFTVDMWYMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X5</accession>
    <name>A0AAE0K5X5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PHD/FYVE-zinc-finger like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_312054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="777"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1333"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3370247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1642" mass="186309" checksum="91AAE6F0B785D07D" modified="2024-05-29" version="1">MAKDASSDDELVDGMALEPAAYEFQSDLSDNEDSAPLAASPPHRVINGVANGPDDMVSYASEPGTQIYEEAHSPKRLRSSTATSTRASSVTNHAKIVHIDVTLPWVPPKKRANFVYIDVADDIDELAGGDNHHKSRRRKHMDSFGNYHMDDSFFEGDLKKRKRRGDDSDYSGQDDDSEPRSFRRKQKVDYYFESSGGKRSTRTSTRATSMSLLSDEEADLPRKGRALRPRAEKHVSYARPTLPDDDKDELQDNDNSNDGDFTIVQSDLVTSKKTKKRLRLSSRIKPKKSSAGRRHSDNFGSDIEFETRRSSRANKNTKSMVDYADDDEFEYYEEKAPGAPKISSMREVFQPPKSVEFKESHRPICDTCGYGEISNKGPLVYCQGCSNSYHKNCLGTRSTREQTVTKVGNDSFVMQCRFCTCNYKKKDKRLPSHDTCQGCTKQNPACVPFSQKKTPKQEEKLRLENDGVDPIIPVNPEYIENSDNVLFRCGKCHRGWHYEHLPHPTKLRDPAIDDPLNLRKHRRDEYQIEWLCKLCIDTDEEKVDKLVAWRPVDRSRYRRGQTILEFNEDDVEYLVKWMQKSYNHCIWVPGQWVFGVVSAISRQAFLKRTFGESADADEMLDDRAMDSLMRWTEKEAIHESWITPDIILDVQCVPRPKDLEQKYKYLSRDAKMEDDKGRIFHITKILVKFEGLGYDDVVWDTPPPSDSGALWNAYLDAYHEYLNGKHFQSEQWKNMQTRIDHFRTLNFTSEIEVKEQPKGLTRGKLMKYQVDGLNWMLFNFRNERSVILADEMGLGKTVQVVALLSSLVQDKPKIWPFLIVVPNSTCPNWRREIKKWAPDLRVVAYYGGKESQKLALQYELFPNGSRELKAHVVIMSYDSAKDTETPRQFHGIKWAGLVVDEAQALKNDENTLYKALLAMRIQFKLLLTGTPLQNNKRELFNLLQFVDPSRRAEKLDEEFAEITKTNLSELHEMIRPYFLRRTKAMVLKFLPPMAQIILPVSMTVLQERLCKSIMSRNPELIRSVFARGKLKANERGSLSNILMQLRKCLCHPFVYSQAVEDRNTGPELMRRNLVEASSKLLLLEVMLPKLKERGHRVLMFSQFLEELTILEDFLAGMELKFERLDGSQSSMEKQKRIDMFNAPDSKLFCMLLSTRAGGVGINLATADTVIILDPDWNPHQDIQALARAHRIGQKKKVLCFQLMTVDSAEEKILQMGRKKMALDHLLIETMDDKEGESTNDVESVLKHGAAALFGEGQKKDRIHYDSAAVDKLLDRSAEEETKVDGDKSAESAFALARVWAHDEGTLTEDMAADEQTLNPNVWDNILQQRAEEARKEQERITETLGRGGRRRNAANYTSQNFDFEEPLDGLDSDRGSGDDDFIGGEESAPESSDDDDEGKNLQDIKPQESTGHPNIEPQITDPRQLPSQSNQKVAREAASVPAVDPRKPTSQSYNVAQRPNIVPVNQAAPVPSTSGHALVPTPRRRGRPPGSLTRPKVPQSVHGAPQPQGKPPARVSVVPLPATAQQAAARVNVNTILKQAAPATNPTVVERPATHKAIPPQPATPFRAAPAALPLQLPVDPCIVCGYLHPVASWECPEMKQEVCLRIALDKLRMMTHLKPQEVVVKKVFLLEKLRLLKLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5Y9</accession>
    <name>A0AAE0K5Y9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_319553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5Y9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173622" description="DUF8021 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="3">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="283" mass="29880" checksum="38E2C67BB1FDD102" modified="2024-05-29" version="1">MLRSLVFALGAGSALAADCTRESLQAGADSLVAAQAAGDPSLLKPISDTLSYNENFKPATLKTGILATAIKIDHSRHSLDTTKCATYTEIISATGSKPYVVGVQLYFAGSAISKVDTLVTSTGDWLFNATGTLNWAKKEAWDVIPVEKRDSRAVIQAAADAYCDIFNNKSVVVPWGRPCARLEGGAYTGNGGPNDKCDVGIPNGVALVDRRYVIDETVGAVDVFLSFAGIPDSHEFRVEGGKLRFVHTLTVMTARSSSSGKGKGAKRVKKARAAAVDDDTCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9D7</accession>
    <name>A0AAE0K9D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cortical protein KAR9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_298974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115239" checksum="0056BBC08A46DE72" modified="2024-05-29" version="1">MTGLSAAAPGSSDRENLNISATAAALDADTSARDASNHVDAHALTFSDIPSELFRLRSFENSPSQANAHNDAQQRPITHQTGRDANNKSNSHNSNLLHTIQTPPPQSTPASTPPIHHPRKPSPGLAARLKALGFGTSRKSSSPPPSHLLEPVGRLPEEQLRKLDLGHQTGTSVKPVVERRGRPWKGLARIPSRSSLKADRSLSWAPTDDGAHEVADTEVKTKLLPQISTSEPLEMDTNKYRLPDHTNGNGVKVQRETREEHIARDTRPPQTPETPLSKDLPPLPQSYANSANSSDVFNPDSVTYFNPLGLQRPGSVYTLSRASFADQLAQLTSIQLPDAELLSTKISAIPTAQAATRALIGSAEQIRGWIFKASEVIGGLESDDDVEWAAAGGREGVEEVENAIERFEELINVYVSAIEDLQSRGDIGQVSPDDLRRAVAQMESIMEEWAKIRNTLHNVKAQVEIAMEWEELWNMVLGDIQNEMDDLSRLVFEMEERRHKSILAVSTGDGVDIGDLETIVEDTPPVASRLQAASNRFSLPAFPVSPSSPSPGATGISQDDSSLLALFARMQPLRASLDFLPMRLSVFEARAEGIFPTSCEELEMRRSNLDATYKKLEKDAESLRKELGEDRWVLVFRSAGRQAQKMYESVERGVSRLREAVDAGMHLTNQPMMSKKIENYEAKKTHYGEAIERVLSIIDKGVKDRLTVNGEILRLHTEMQAKWKDLKERMAELDGALEDLQADKKGQQLRDSVSSMLSNDRSTIESGNETPQSSPPSSVIMSGLGFSNPTNVKAPKQRSTSIGSQLPQPSSRRLSSLPTPTSQAPRKALTPRVSELSTPSREGSTTPTGNRSSRPGSTLGNKPKWNGSTNTSDVDTGHNFKPLTLTTPSPYAKRTPTPMRSASALTPASVSKLPMLRSPLARASSSSPIPEDTPSRLAPPAGQLSFRERLASPGPYSQQTLARPRLLTQASMSGLSNRRASLQPPKPLEDSPDITPRPASSLAGSRRTSLLPQPRAKAGVTGRESPQAVAGARFAMRQNSTSSSDSRNKDSKPRWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9E9</accession>
    <name>A0AAE0K9E9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_551191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9E9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="247" mass="27932" checksum="0BC46D1854A752E2" modified="2024-05-29" version="1">MEVPSPTKNKNNNSPCHSRSNNNNNNNNNNNNNNNNNNNNNNNNNRNSRAFGARRSAKNPAFEDKLQHMMLPLCPLVQLSTGSVHPSFPDMLLKYWLLTSDELDALASFYHQRTPCQWTMHYPCPIAWPAGLSLEEKRRKFGKFIGLRGCDTPAPPPPPPSPNNIPAALAESTVVVDRTTGRKRAKTEEELAEDARRARLRDDEGVRRKMGASHILYSIRASESVINIKITYLQLNVYREVIERCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9X8</accession>
    <name>A0AAE0K9X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_527189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="12265" checksum="D3162BEB21E51777" modified="2024-05-29" version="1">MALQAYRHLMRAVRVAFEGDARVLDAARQQIRMNFREKATLPASDPSIQPAIQHAEEVACFLRANVVQGKKEGDRYKLRIHEDTERGDNDTIKVAGKTVTIDGKKCTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDF1</accession>
    <name>A0AAE0KDF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_437648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18433">
        <property type="entry name" value="BRCT_Rad4_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17723">
        <property type="entry name" value="BRCT_Rad4_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="332"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="441"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="923" mass="99577" checksum="377B36ABB1FFDE10" modified="2024-05-29" version="1">MAATPPGSSDVASLAFDSAQPFKGLVVCCTSIAADLRTEIATKTVELGGLHKYDLTPDCTHLLVGEYETPKYRHVAKARPDIKVMAPGWVEAVRDIWVQDAEIDFPAMEREWQLRVFETGVGEPTEEGAVAPRHQLLCCMTGFEDPDTREQIAHKISSNGGIYTGDLSRQVTHLIVYKPEGRKYLAAKTWGVKTVSIEWVNDCIERGMILDEKLYDPVLPPAERGVDAWDKNFERKVSLGKRLRENAAAQDEGRRKLCKTASMKLNSQRDNLWGNILGKPSATDPSGPSVTRSLSNPPAPAATAAQCNLIQQPGAKAMDTQGSRLSSFGMPEDGNVFASCCFYIHGFSDQKTEVLGNAVGSLGGLVCRSLDEVVSASGAQLAHRFLIVPQTSAPETHPRLPDNVHIITEFYIERCLHKKYFFNPSEHVIGRPFPAFPIDGFEKLTICTGGFTGVDLNQVDKAIRQLGAKYEERFTADVSLLVCPKLDVVRKQKLEMALAWNVPVVNAEWLWECITTGYNVPIEGFRFRILEQKVGEPVRKGTANAQVGKEKSKQDKTSVGKGPFDKDLLPPKAAIKSKPPPGIDFSSVSILGGERKAPPAKAKKSGAVNDPESAFSADTHFHTAPTHQLETSHSENSNSRSSGCRKAPSAPLSEASSNSLNKDNTPSPAKHEGGARGQRKPMGRITSEIADSEATDGDVCTPGDLPLLADENKHEPSPIKPIVVKEVAKDLKATRERAEAERKAQSSKLALSLLDSAASLTKTLSAASDAGESSGGAVSNTTSFAGAISGTTTTKRRKREILGRAVSNVSAGSSTAGDSGGGPIIITTDGLGLGGKHQQQSNPLSVSATEEDGRPPPATQLEYEDPDAKRYQAQILHKMLGTAPPPGESSFPREERITMAEMAGYGARVPPLGEGRERRSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE03</accession>
    <name>A0AAE0KE03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_480895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="84" mass="9423" checksum="66038579F957783D" modified="2024-05-29" version="1">MGTAADRRRQGLASELLVYMQEQARSDGRPLWLEATTKYSRDLYLKYGFTIVGEAVLGKGKVGPDGLKKKGGEGITTWLMFWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE99</accession>
    <name>A0AAE0KE99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_452438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE99"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="175"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="411" mass="46181" checksum="073F1E7327E063B5" modified="2024-05-29" version="1">MPTVSTTTQRKLAAQFIGVTNATKENAQAFLKNANYNLDAAVNLGAGMTAYPSSSHMASSDTLDSDSRVMVLQLFKSCFQKRPTRASGKSLKQDDRVTEAESGDSSQHSLPSLSRSRDAGNVSTRQGTVAPASLAPIFSTKDTKSRKTKSTSKSTSKSVLGTLVRYFSSAETESNDDEALSAMFDKLRSGDDETNSIGLDSIEKYTKELGISVEDYTFFVLCEILRVESYGQITREGFIEGWKSAPEYRDSIGKALPLAERHRKYLRQCIDKITKKPRDEDYYKAVYRRAFFAGKDPEQRAVDTPVAMAFWETLFDPAIQPWQTANTDWLDAWKRYLEETWYHNGTWKRSVNKDTWNQTLEFARQTMKDGTLSFWSEDQAWPGVIDNFVAWCRENGIAPKSATDVMDVDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEQ0</accession>
    <name>A0AAE0KEQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">B0H63DRAFT_482924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEQ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3375443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="172" mass="20220" checksum="CAB983FE45068A9D" modified="2024-05-29" version="1">MKAYLYDNLPGDQRLPHDSGKAVDVDSLGKLGVLYYRIENIEGVNQLAAERGYKNRDEITVSPEKMGDVYEAKVKSFFDEHLHEDEEIRYIRDGHGYFDVRNKGDQWVRIQLDKDDLLILPAGIYHRFTTDETNYIQAMRLFKEEPKWTPLNRSEDLDANPYRKEYTSHFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEV5</accession>
    <name>A0AAE0KEV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase Family 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_549265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEV5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="599"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1264" mass="137294" checksum="DF8AD2AA3ED61E51" modified="2024-05-29" version="1">MGTQDAHRAPAEDVDKDGAVQFESILHQGHEVTVVRDADGHPVYPTYVPPATQSPTSPQSPTSPTSPPGTQDQQKVPEPSQQHPRKSQTEPPTLKGPARPSATQWASETPLRGDRSDSILPYAMKRAGTNLSSVDPKLWTRPRTTQPIGYDGGDTSSSDSSSSEEHGTSVETKQQRRTRKHREREEKFRRFHVGNDNYRTKGKVSKHDGRLNISVKDTSNTGYLAKALGTAAKRIVPPPLKKGADGDNAGTRPQSVSRLSSASTTAGLDNTSCPKLNIVIMVIGSRGDAQPFLKIGKVLKEQYGHRVRIATHPAFREFVEKDSGLEFFSVGGDPSELMAFMVKNPGMIPTLETVKAGDIGRRRAAMAEMFQGFWRACINATDDEKDTHNLKMMGTKDPFVADAIIANPPSFAHVHCAEALGIPLHLMFTFPYTPTQAFPHPLASIKKSNVDPGYTNFISYPLVEMMVWQGLGDLMNDFRVKTLGLDPVSTLWAPGATYRLHVPFTYLWSPGLVPKPADWGDEVDVSGFVFLDLASSFKPPEPLTKFLDAGEAPIYIGFGSIVVDDADRFTQMIFDAVKLAGVRALVSKGWGGLGGDSLDVPENIFLLDNTPHDWLFPKIRAAVIHGGAGTTAIALKCGKPTMIVPFFGDQHFWGSMVATAKAGPEPVPYKSLTEEKLAEGIKYCLTDEAVKAAEEIATSIELEGDGAENACRAFHKHLALSGKNSMRCSILQDRVAVWQLKKTNLRLSALAADFIVQRGYVSWKKLRLLRHNEWNDFEGPGEPVTGLAGSLLSSVGDVFGGIGGVPYRVHKKASERRERKEKRRKRRDKREEKAAAEAEKAEDSANTPQPAPGIEATDHAPQSPPVEKNTPPSGEDGEDDEDDDNEEDAPNVTTTTSNAIRHTNTTLTASTAEPENPAEEFVTQVGRGAYKSASALARAPADLSLALAQGFHNAPRLYGDDTVRRPTRVTGIRSGLRAAGHEFIYGIYDGWTGVVRLPVRGARDGGVRGFVSGVGMGLTGFVLKDIAALIGPVGYTLKGVIKQAHRGRQPVKYIRRARIVQGQREVRALPEGEERTKVGEQVVRGWEVMRALWEALETEERKKTGGGLKAKLTGGVVRRRRRGLGAAFESVDTAEKALTALSKGEGIEGVIGDDPGRTSSDVGKSSAKVAKKGAADTNKKKDTSGGAPERTGSDEIDGSGRADEGKQHLKLPAVDDAETKDDEEEKDNPFSTNRLDVAKNKADNQAIVEGEEKEWDRHHKGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF91</accession>
    <name>A0AAE0KF91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_437853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF91"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF105">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="682" mass="77253" checksum="FB7FF5543222A9FF" modified="2024-05-29" version="1">MYICRACLRRGLGALQGTTSLRTTRLVGASQASTVCGPSRRAFTTATPNSTTSTTESFTATLEKATPVTEETTPAPTARKSTSVAEADEQSLEKPSTKRLEWVVNKHLQYLKDPFDIAEHVQRTLDKGLFDEALLLTRKASRDTPVEVSWNHLIDYQMKNQRLHAAIKIFNEMKKRAQKPNARTYTIIFRGCAQSMHPKLAISEATRIYNTMVTTGTVKPNTIHMNAVLECCARAGDLDTMFSIAATSDESLRAPNNQTFTIILNALRHKPDLSRRQLIDEEVVEKNIATNIQRARALWEEVESRWRKAKLIIDEELVCAMGRVLTGGNYADHNSILELVSQTMEIPNFDKDPGAPLPKPKPPVEAESDAAKTTLPVKQAFKPKYGLHPEPGRNTLSLILTSLRFTKKASLAPRYWDLITTSYSVIPDKDNYTRYLKVLQRGRGSTKAADIICTMPKEFLTSHIFRTGMSTCIHDNLNQHAFANATRIMDVMSTKVRYPDAMAMRLYLEVARNNTRHIFADKDQAEINKLLGKQLAMATDRLWQPFRILMGSFSYPQKMTKSPEHAWELSEGDMIEAMATARRIIAAMDKVVFQQLVDDDNLIRIIKTRRNILNKLVERYIEKKYEMEDKMGKPGKRDKPGEPARRNNNNNNNNNNNKNDNDNDNDKTERVEVLDPIPGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJS3</accession>
    <name>A0AAE0KJS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase S28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_511761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJS3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="665" mass="74718" checksum="2DCA433F97DBDE60" modified="2024-05-29" version="1">MRPNWAWLAGVTAAQSLLYPPNSFHQLLQRRKATDDEPEPEIPHVPQYNASIPIDHFSDTDMRTFSNRYWVNDTYYKAGGPVIFAGLAEGTGTNKRLGYLLAEYNKSSVTAPMHLARELNGIVIAWEHRFYGYSQPFKLAEKGEGERGNDMPVGGVDDYRYLTVEQSLEDIVNFATKHLPHATLSENKLRWEPRGVDATPKPRDHLCRVGVVSPRRVSYHNNIHHSMPRNCTNDLAAVTDHIDRILSISDLHNDTLLDLKTAVYLAVRDPPAEHPDTATDDDDDDNDYSTQDTDVSLFSEETLAQDLVANASKRTPLDVAFCLSDVSFRSLQDQGPSLTVHPFCSYIETFDTNLYRETQNLHQRHYFTKTPSSKSSSHLQARNRLARVSTFMYTNLTSKSRVTAPPQDGIIASLSSPSNNSEALEIGLAAYLHAIWRHKSALSNLDRLTFPLPRDAHAWQWQTWTQFGLIGFHNVSSPYRVGSKFYDFQAARRGYIQRTLKAALNRTDPDDDNKNDSMYDDDDDDDPSVVPDTMYLIGYGGWGMQPSNVMFTDGEYDPWRAFSVSSAEKDIGAPGRKMTQKVPKCNVPPEGGEVFGMVHAGAVHGSDVGAYLVDEDEVEEGYPAGYYPTQFWTAAGLIVKALREEWLPCFYNKTRGREGGQGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK46</accession>
    <name>A0AAE0KK46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_547545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="379" mass="42917" checksum="745528F6C0FABBF5" modified="2024-05-29" version="1">MGYRAYKMKSRIVDDSVADNSRDIYILQAKGAFTALLNGGENPVISKSSRWESLPKFSFHALRDLVVPAPIRLNKNEVGLEEGIIINLDDLYSNRVDQTTVDRILSRDRSTRLALSSSASKNKRKHEDWLRKQQSQEVKDVLFTVRRNVSSAQLIFNEIYDAKTTCSPDRLASLRKKLREAHKNNMEEFIRSCETEAETTTKRRMSIEFSHTVSSTPLSKSRALSTRRPSEYYFTVSENSSVARKTGSSSSWVVVYDPETDKSQAAPDSTRHSAVTAVSDDSLHNLIWTPGFRIASPNAFLGDCPFCEISGAPMTVIMSCDETQVDERPLLVSTDDVDDEDIDEYRYRHLIDPDPEVWPLATGHVTSEERMHPMSMFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKU4</accession>
    <name>A0AAE0KKU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein BOI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_398320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKU4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11886">
        <property type="entry name" value="SH3_BOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035551">
        <property type="entry name" value="Boi1/2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="723"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3378085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="104512" checksum="EF6015AA73EF3A73" modified="2024-05-29" version="1">MAAPGSNKPEAGDILMVIHDFLARSSDELSLAKGDRVELIERDDEFGDGWYLGRHLVNGNSGLFPEVYTRLAPKAAAAAPAPTILPAPKQPLAPLVETVNEHTTPPVSPPPPEEIKTAPLPETQPAPVTLPLSSFKSASVSGGPPPYSPSSLGMGNLGRPNASTDSHVLHETLNVIDEHITDLSSPQINGGLRNTGDSGSEYSSHVGHRISYINGEETDEEEETAHSRFEVESWSADQVAEYLFTAGVEKHHCEVFRDQEITGEVILGMDQTSLFIKAFDLGSVGRRLKTWQKIKNLQDEVNGLEIAGTRRTTQTYGSDAGSDAAGRVRSRTSTMTSSGHQHRFSPLDGRSISVQTKRLSQTPKLEPTQPVSPVSPLVESPSRTFHERRPSAASIRDLHHSRRHSSTNDFRLPSAPLNTTATTPKLATGGTFPPVTTQSSGVHKKQPSFDRNWTLGSATNAYTQRPLSSAGIQDVMNGQGQQLQDSAVDLDRGYFSGTDADPRRRNVLRKRDSAAQSTGSPKSSYADEQRVRSATALSRHSRFGSVDSVRESSPAAQKYFGLTRRTASTNTADSTRPAPISKDSTPPTVTKLEGSPDQVRASPKSAMKRLSQVNHPDFNVGAVLRSGFGFRATSEAVTGTEKSKVSSPADLTLKDSPLYSPSRAGSSTPSAGPSFELDSTDAAKSPSTTTTANSRNSRRKGKKETSAYTRGLQRISPREAIADADYSGWMKKRNGNLMTTWKPRLFVLKGRRLAYYYSEDDEEEKGLIDISFHRVLPADNERLTGLHATLTGASNSPAIPAGSHVPTLAATDAEKDPIKESDAMFIFKLVPPRAGLSRAVNFTKPTVHYFAVPNIKQGRLWMAALMKATIDRDDTKPITTTYQQKTISLAKARQMRHRPPALMNLDEAAGDSEKRAADKKEANGLGIVYSEANSAGLEKLGLQQIESARSRGGFGLGKETLLPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL45</accession>
    <name>A0AAE0KL45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_248675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL45"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08039">
        <property type="entry name" value="Adenylation_DNA_ligase_Fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="392"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119381" checksum="C3EDE9973B841155" modified="2024-05-29" version="1">MGFQFSYVCDLLQRLEDAQRAAVRSTSTTTTPRTNNANGIISEWFRGHQTQLARDGQVDTAALLSTLLPEKRTDRVYLIREKKLQTIIGRGLFLGRSRILELERWTVAGSGVDLADCVSDILTQTPSPPSCENVTVEEIDDLLHSIAAGCRFSSPAVRSSAPSERRLTDNELALGDLYRRLTARDAKWLTRLILKNFEPVVLDPQTVYRSCHPLLPAILQVQDDFTVVGATLARQRHERTVTGRANLADYLKPALGVKVGRQPWIKGRSIKHCLDMSLGRMSCEEKVDGEYCQIHIDLSKDRDCIQIFSKSGKDSTNDRMSLHDSIRQSLQLGQTSCPLKKGCILEGELVVYSDKDTKILDFHKIRKHVSRSGTFIRTDQDSQRHSWEHLMIVYYDLLMVDDESLLAVRQSERFQRLKDLVTIVPGRSVLVKREIIDCTKRSAASDLRRAFARCITSHGEGLVLKQDDPYFNFDTSRKPYSCCAIKLKKDYIGHFGDIGDFAVVGARYDATKAKTYGIPNLKWTHFYVGCLENKDEVERFHKPPKFVVTNVVELNVTQLKMFVTFVNPQSVAPEENKATYFRVEMGVDNGKRPSAVFPVPPVFDLRCFSFDMVGNTGFCSPRFPMVNKIHCDRTYRDALSFAELQEMAIRERELPPPEDSQELLGWIAALEAADPKGTVSVDESSQSTVATLRRCETPLTQSSQTGLPTSPPRLGIPVTGNGPPTLPKSSAVEALVQTPLNGAASSLRGPQGQKRPHESTVPSTTNRRKARKSDNDYSTTSAIVSQKESRNAASLSNDREPLTDIRVNSSRRNNVPRTANPSLGIAQSMYQLSSEDNPRLSAPERAQTSIISASMSFQGVFAAPQASSDLAGNVAAVIRKARSQSEGNSRERRIDYTSAEAGGAAAAAGKCRYLPTSCTLAPLLFLLSPCIADFPWVTEDLLRCHGIVDFARDPKTWPVPKRLNSRAIRSTTDPSASSRKGKNTPWGRKKRAVLVDARRKEATEAFLKCIVDAQLKGRDGKKEYVDVYDWRVLEALKREEEQVSRNGERPDASLSSSMAQGIWRKFWVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL68</accession>
    <name>A0AAE0KL68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_480150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL68"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3378514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="475" mass="52474" checksum="BA0DD4A6C95FB170" modified="2024-05-29" version="1">MIARVSKMANNKIVEGVFGINKPIGMSSAQVIRDCQTYFNPSTLFAPLLQQEKDLRDRENQYQQKRRGRNNRTTQVKIGHGGTLDPLATGVLILGIGKGTKSLQNFLLCTKTYETVVLFGASTDTYDRVGKIIKKGNYDDITRPMVEKALEGFRGKFKQMPPLYSALKMEGKPLYEYAREGKPIPREIATRDVDVTELELVEWYEPSTHNHRWPTDEAEQAEKNLVDSVWRVAKKQVASEETVTLTAEQQEEETKALADYQSKKREADDRVDSLVSENGRSPKRKKAEHAQKSEPLMSGALGELPPVGKGSNLIPPPPSPNTPPPWEGKGPPAARIRMTVTSGFYVRSLCHDLGEKLGCGAMMAELARTRQGEFVLGGPNCLEYTELMKGEAVWGPQVESMLDLWQNKGVMPTATPAPTASKPSEPTTVDSARPSASKEAEVQQEADKAGQSEDKSSLATEVAAKNQSKMPKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLE4</accession>
    <name>A0AAE0KLE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease III homolog</fullName>
            <ecNumber evidence="7">3.2.2.-</ecNumber>
            <ecNumber evidence="7">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="7">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NTH1</name>
        <name evidence="10" type="ORF">B0H63DRAFT_478833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="7"/>
    <dbReference type="EC" id="4.2.99.18" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLE4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="659" mass="73621" checksum="B86D4CC90151C787" modified="2024-05-29" version="1">MRTSRVARETSGFFDTASSPTTTALPRRSTRSSTSLAARFAYSSTVKHESTDVDEDEDEDEKITYGSDIEDSIKSSKSPPPHSVTGDARKRKRTTTVIKRELAQSTVALRGAKKEEETTSDESKKKIKREPVAKAVRGDRKVKAEPRRIVKAETKINTELYKASESESEAQDLESILRKPASSRARKPARRALDAVTGEITVQPPSDWEEMYDLVKAMRISGPAANAAVDTMGCERLADPSANARDRRFHTLVALMLSSQTKDTVNAEAMARLQTELPPHREGVAPGLTLENMLAVEPAVLNELIYKVGFHNNKTKYLKQAAVILRDQYNSDIPPTIEGLMSLPGVGPKMAHLCMSAEHGWNTTLGIGVDVHVHRITNLWGWQNPPSKNPEMTRLALQSWLPRERWKEINWLLVGLGQKVCLPVGRKCGECELGLRGLCKAADRKKVIEGMKRRDLLVKEEVKYKMDGEDVVMEEEEKVVIKKEKEKVIKREVEQEEEEMIALGDVSANEEEDISLSPTKKEERAADIDNEVKIKAGSSDLEHADVNENKSTSDVVEGPSRVKIKAGSPDEDHVDSKIKLSIEFDDAKTKLDSSTPSAEPEGGAGRKVKVKLEETPAKEEDKKVKLESEEVKVKKEEEDEERGRRTRGHRDRLAARRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MZK0</accession>
    <name>A0AAE0MZK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_540196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000027">
        <property type="protein sequence ID" value="KAK3365396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MZK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3365396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="773" mass="85731" checksum="52CDE4126F398C64" modified="2024-05-29" version="1">MTRPKVPDDKRQRTAQACDSCKRRKQKCNGVKPCTTCTRRKLTCTYTSNNMPTMRRHIDTSPQSIHALLDGFEASPPQHGNHGQSQLWEDEDDEGLNNRSIKAGSSTSTPTALLLPSLSGHEVDRKTSTLVPKTHEPVIPANGQSEETTIYTETRMLQDQTGRLLYIGDASTLGHRIMENIIDFPEDTRVPSFLPDKETTDILVQSYFTNTCGILEVFDKRMFLDDIEACYNDPLSATNYFLCHLFLVLALGLLLAAPIPGGREEVVIQKQLSAKLDRAELFFRSARSMSDPGAGFEDADFWSIQALSLMTVYMLSVSKRNTAYAYLGMAVRSARNMWKTLFILDRFLAASLGRPTAIAEDDCSCDLYSFNSTNNHHSTSNSTLESVHLKSLDACVRSCHVIGVTLKVFSQRKISTAKVQEIADRSKDWHRGPRANLHGLRPTEALVDSAQGIASLHDNLLSLHSLILLTRQLFVMHNWKLQEQRSGMAKEIPMHQSPMAKYSEACVVASYQTIQLVQKAKDEKYLPRRNPFVIYFLFVASLIVFMNQFASLYYTSAYAQTISDALALMEYCAETDPQAKRVLEIMHKFATVVAKWTQDHTYRAPPLAADLNNLYSQTSSPQTTQGRTGSVSSVLSPREHSGVVNIPHQRVRLPLSDILISHPTAPLVDTRMNGITPPQTTAPGLPQPTSSRHSLSSHSVIEGSDSLNGDIEVDFDGLWANWINHVAPVSAVPPGITNLAPHFPASILGPPVMSLCIIRRTSGNASSAQQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0H9</accession>
    <name>A0AAE0N0H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_405493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="90" mass="10706" checksum="D9FD026C8DDA9C79" modified="2024-05-29" version="1" fragment="single">DSQAGPHRCERINPITWRPCNIVFSRPYDFTRHEDTIHDINKPKARCNICTDEKTFRRQDALIRHSRRCHPGVDFPRQPRRGTPKSRQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0Q5</accession>
    <name>A0AAE0N0Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_93168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="80" mass="8710" checksum="1655E3150F6D41EE" modified="2024-05-29" version="1">MYIYLFCSFGFVVSDLDADLTRIAETALSISSSVASYSSEDDSIWDRQDECSNASTLLSSLLDDDASVVHSKDNGDYPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1Z8</accession>
    <name>A0AAE0N1Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_529892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1Z8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="202"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="363"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3366509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="94866" checksum="CA50C5015C26EE5A" modified="2024-05-29" version="1">MDQSLFSTAAEIMPEEERENVNYSPASLSGMVSTLVPTAVLSSVLFIIFLFLRRTHRQFYAPRTYNKRLQKRPPALPDGLLNWFREFWHIPDVHVLQHQSLDAYLFLRYLRVLVIICLVGCCITWPVLFPVNATGGGGKEQLDILTYGNIGPDQKHRYYAHVFICWAYLSFVMYLIMCECIFYVYLRQAYLLSPSIADADESRVVMFTSVPAPFQEEKALRAIFEQWEIVRISLPKDTTELDKLVKERDKAVDRLEAAIVKASKPKRGPVATTAAADEHVVRLYKDVAKLDGKIQEGRMNYENNPKKLPAAFIEFETQEGATSAAQCLAVNDVLSMTDIHAGIRPDEVNWKALAIYAWERVIRRYAAYAFVATMILFWSVPVAVVGAISNVTYLRTLPFLAWLDEIPATIMGVVTGLLPALALSVLMSIVPPVMRLCAKFAGEPTRSTVELFTQNANFAFQVVQVFLVTAVSSSASAVAKQIIEKPSSVTTILAGSLPSSSNFYISYFIIQGLGIATGVLTQLPGFLFFSLSLKYFCVTPRAISTRWYRLNIIQWGSIVPVYTTIVVIAITYACISPLMLGWATIGTELFYLAWRYNVFFMADTQIDTRGLIYPRAIKQLFVGIYLSELCMIGMFGASVAPGPMVLMVAYLFFTVLFHISLNRALSPLFSHVPLSLFAEERKNRSDPEVAIMSATSGDEAAHAVDTLPEGLLKTLGLSIRTLLVPWQYLNYRNLRDFFDTVVYDQNGGAGIERDLVYHPPSATARKSIIFTATDPHSRTRLQNVVEILGGVVDVGKTVLCIKALPGYGVDQTGVVKPIDKDQPQYVPALPESTSVENPSSQPRQPLTRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2V9</accession>
    <name>A0AAE0N2V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_534212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2V9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="139"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="780"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="421"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="826" mass="91783" checksum="500DEF1D16393912" modified="2024-05-29" version="1">MAAPHNKHRYSDIHALRGGKPELGDLALNAFHLVFRFPPESITSADPGLKKQVKQVWFAFHVISQCVLRPTPPSSGIPSSIRIRFRDFTYVSFNFPDDKQARDAFDFIRARTCRLGSIDKLLAFTFSPPPASPEHKIDGWGIYDAKAEFRRQGISEKAADLGWRITAINKDYAFSPTYPAVLAVPSKISDNTLKYAANFRSRARIPTLSYLHPVNNCTITRSSQPFVGLRMKRSIQDERLVGACFSAASDFIDAPLPANADQSPSSSHVDLSADSAEIAENDLTMSETERMEDELIAGNAFYDDKTGKRLIYGAQQHNLIVDARPAINSYAMQAIGMGSENMDYYRFAKKVFLNIDNIHVMRESLEKVVSAIKDADVSPFPPSRDLLVKSKWLKHITGILDGSAIIARQVGIQHSHVLIHCSDGWDRTSQLSALAQLMLDPYYRTLEGFIVLVEKDWLSFGHMFQLRSGHLSHESWFTSDTDALAGLAVKPGDNDGRGDAIENALASAKRFWSKNLANDKDASIEGDDTSAVDEAKQEAVPVAEGQATRLKDVSPVFHQFLDAAYQLLRQHPTRFEFNERFLRRLLYHVYSCQYGTFLLNNERQRHEAKLQERTRSVWSYFLSRRQEFTNEQYDPTVDDHTKGRERLVFPRLNEVRWWHQVFNRTDDEMNGDLNASAATAERVAAYAQQTSSGLSEPSISTGENNGNQMEPTSRGSMSPARSPQPPALTSSQSVLTGVESAHEALTPEARSPPTLNRGSSTGEMPGALAALQDKISGMGIANVFGGRSSPSTGRNRAGGSSRRSEDQPSNGHQDEGGGAQEMKSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2X0</accession>
    <name>A0AAE0N2X0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274180" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="158" mass="16605" checksum="B12BFE38F309F49B" modified="2024-05-29" version="1">MLRLLCTAALLLASLGNSSLVKKDDKPSCHPPYTTLTTLTTTIANPTTSCRSPYTTLTTKTVTVDTTPTPTITSLDASCTTTPTQTFYSTSGCALTCSTGFCVIDAAVTVPCGCSSLEIRTATITICPTRTPCYQCYTGWGTFRETATCPPTTSPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3U8</accession>
    <name>A0AAE0N3U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF13">
        <property type="entry name" value="CATALASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="123"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="31718" checksum="F83345DC534021D3" modified="2024-05-29" version="1">MVLTPNFLGVADTALDDQMDPIAGVALLVYTLSGFDGGYIESHVQEGQGGSQGAAHVFARHDDQLGPAVGDDRAIPDDVHLLLGWNGPMHTRAEVAMWQISGITSPPSACFLLDPYYPAPKRVPLDSADYPFEMGRDEPLPLQPARQDHQQVPPQSPKANFLSTIGEKTPVFVRFSTVTFGREFPDEGRNPRGFAIKFYTMEGNYDIVGLNFLVFFYRDPIQGPDVIWSQSRNPKNFLLDYDALFGLLANTPEANHASLIFFSDYKAVAMCGRDPDYSKRDLWDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6J3</accession>
    <name>A0AAE0N6J3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_286114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6J3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="410" mass="46479" checksum="17D5A3D720CBCD14" modified="2024-05-29" version="1">MDEVMGELMGLTTSDIYVFAEATLEQQQLTWELTGISWARSSAPPMSLDVVHARHVYVAREQHLSQQELSKDGRTRCWVLYLKGYPRQIIASCETTRKTILIAKDGISREGQGYAIASVSTNPIYREQGLAAFLLRHVQEQMDKDSDCSVLYSDIGKSYYSSLGWRVFPSHQATLTLLSSPTTPPGDSEEGITKPAFRHSQPARIRYLRVTELPDLCKKDELDLRKRFEAFPAGDGSTHVAFSPSFPQIMWQLERAEFMAKSFVDKKQTETLLPNKGAITNDGKSWIYWDHDWREKKLKILRMSIRVEEDGGDHSPTVAWKQQRHRIDDIKVLLEAALAEASAWGLPKVLIWNPDAEVTLGCKAAGNAHPYGMKIVFDERKDASIPSLRWAGGADGRDTSWEDNFYYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6M7</accession>
    <name>A0AAE0N6M7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6M7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="199" mass="20659" checksum="6727F637D30FF803" modified="2024-05-29" version="1">MSTATPSNPEFFIAPPEQLAASSKLSAVVITMGIPHSRDLDPQKYTAWVSIRHHRGWSFSVDFVFRSFGEWRPEPSSAIPQSSEKKGKSKTAARAKAAVKNAAMKAARWTPHKSTATATAGAAVASCSASAAGFGATANALATAGSTLTASASAATTADPAAAATPTDKASSSNQPSQQEDLFSAEHPELRLPSRVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFX9</accession>
    <name>A0AAE0NFX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_192979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71954" checksum="02907C918530E721" modified="2024-05-29" version="1">MASPVLGLGPLPAAVSAPQPSSSGSLPAYFSSLDRLPNELLQPIAAGLVPASPLTTRFALRPTGTWEFRDAGHQWTDWLAGHNDLLSFAQTSHRMAAIAKPLLYHTLVIHNEHTLVTLYRRMSQRPEINPWIRDITCLANVAGVQTIQGVRREWERQTGVNWQLPHSHADPETIALELLKAIALNAPNLENFLVAFPDHDIVDHDAELSSMDTTLPSLRDAVLRYLTSGYPVNHIDSPVAQFFRFELMGNLKSLRIYCHREEGDRDLSFSRMLADYAMASLPQLTNLRTLELCCSSAGKFVFDESTLPSLPQIENLRLYGSHIHEPRLVALCLACVNLQSLLVHFEASSTDEERDLLPQGKILDEALVGLAGTLRSLELVALSEGHYLTRGRERPRKPENHRLKCIPDLTNLESLTLDYRGVFGTLGILEEDDGERLCQLLPASLRHFTLVCEWGTPSDWKQSYMANLTMMLYGVECLCATLSPRLSTISLAIHSWPARGRFHRRFRRDMEEARLLCARSGIRFRTFDLLPCYQDEDEPEPLEEEQFEEDDEGDEEEYDVLPGVGPVDDEIELEDEDEASEYFFSGDEESDPEREARRPPNFEAFVQLLGEDHGHSFDELFYAWHDDRWDEYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG71</accession>
    <name>A0AAE0NG71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_545086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG71"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="622" mass="68041" checksum="5F5FC9A81F44EADF" modified="2024-05-29" version="1">MDFKSHEAASTRPSRRKTFPLPAPLSGPVAASQTGSSSLSSSSGHVCSVSTVHDVPVILSAGVQAVRLYVHDDFLFSDDSPIDIHLCRDTVHLGMPSYTVASARHIYRACVLDFPDKTGYGDEDEELEGRANDSDGEDENHETHVAPPEGGDPVATAFQRKHKKPRSGFRHILGVVAITLVAVFLAPSRHDPSPVPEYTLLKPLDPSPEIAFADLIQRRAAAPRAVVASGATDYQFLVEAWRADWAVLNSPSNPAGRPEPVKVSTGGGWPQQKAAANDDENDEPYYHGPAHARLSALCDEFEALIETLPEDVVAPLKNIMVSFWGQHAMSGLFSAARGLETILGDGGADTHHYAHAHTPQIDGPASPAAFSPSGESLPTHDNNDNDALAINSSLAIAVLQQLSKRVTLPQRFSRRGVGHIQALDKNLSLVINTGIKLLEPRWEQWRALNRPASYRTSSSSSSEPQITPSEKDLQQLASLGDRARATSSRCKEMQRRFFGPAAECLAVTGPDLDHLKGWMDGLIAGRGWTRLVPARHDSDEDKWVLEWYYFSPRPDLLAWLKSLGRNITAELNEFAEESKQALLEQLKNRVRPDDSWTYGGYKGGNDPTGGFRDKVKDFWNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGI7</accession>
    <name>A0AAE0NGI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_545410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGI7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="497" mass="54256" checksum="F6B132C125EDE7E3" modified="2024-05-29" version="1">MALLGAPPQHAGGPTMFGVPMKQASLVTLTFQNSALILVRIPSVRPPARLPANASVRSNNTPSETCAAIMHYSRVMTPSGDHRYFASTAVFLNEVIKLAISLTFAIYEGSSSLAPQTPVTVLFEQIYNSVFSGDGWKLAIPAVLYTLENTLQYVALSNLDAVHFQILYQLKILTTAFFTTFLLRRNLGFRRWLSLVVLTLGVSVVSLPGSNVRDMSMDIHDFSDHFFPRSVHELGQVAGDVADVAVELTKRGLGSLAGELSKRSATYQGIKEDLDVVPPMNYSIGLTAVLVSAVVSGLTGVYFEKVLKESATPVSVWTRNIQLAFYSLFPSLFLGVIVNDGAEIAKHGFFDGYNGIVWMAIIFQAVGGVLSSLCINYADNIAKNFATSISIVISFVFSVFVFSFDVKFSFVLGTGLVIAATYLYTLPDRKRPRPSPISIVSYEKTTIDSTPSYLDVKKTHLDPMDAARSIASSSSRPNSPLLYHPRTPSSRGKRFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGT1</accession>
    <name>A0AAE0NGT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_560996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGT1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="363" mass="37701" checksum="B5F341CC874CF556" modified="2024-05-29" version="1">MSPHHRKPEVVASKLNGWFPNTKNPVIISAPMLGVSNGTLAANVSLAGGFGMVPGAFNLGPDSPDLATLSAELTTARRILGLADRPLTPIPVGVGFILCDSSASHFLSTVIPPLQDHSPQAVWLFAPDLDAEEGFVRGIIDALHASGFIVFFQVGSVAAARKAVQDGADVIVAQGIDAGGHQAAIGSGVVSLVPEVVSMVEDEFKDRGVVVVAAGGIVDGRGVAAVLALGAEAAVMGTRFLVAPEASTADYCRKLILETVDGGVSTAKSSFHDNLQGPGRWPAAYDGRAIVTELYRDHIAGVSLEESQARFSEAKAAGDLSRQITWAGTGIGLVKDARPAGEIVTDVREAAKKRFHAVQSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH49</accession>
    <name>A0AAE0NH49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin structure-remodeling complex subunit rsc9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_202213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH49"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="664"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="845"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="111163" checksum="87806CE9013F2FDF" modified="2024-05-29" version="1">MAPPKPVPEHSIDRTPEYDKFIEELRVFHEKRGTNFDPEPKMGNMNVDLYKLFNYIVENGGYDKVSDEKLMWRKMCEGLGLMRHNAPADAYTLKQIFYKNLAAYEIKKVHNKEPPPPEILEFTTAKGGSLLTRTLENFQAKGKNEKDESGDDGTPSRERRPEETPGSGRASRGLREAPAPRVIFHPDTNSSRQVRHSSGQQPPAANTPSHHQPQHSQPHHSHSHSNSNSNSNSSNINSNSNTPIPVHGPPHPHPNRGGASHMYNPAPQDPASALVQNYQPPPAQPVQLRIVDTPTSNPELFARKQRLLRQQTSQPVSSTSALIRAAVPNTSLDGPNIYERCLLALRSGIRSEQAFGLNHLVKISYERGDKYKFSQFSGLAEGLTEFALGVGSLFYHVDWIISNDPELDDADIGVLDGINGSSDILERIAHLKPRDVQDNLQPAEFTDHLTLITEAVLTMRNMVMLQENAWFMAEYLPLKDLLCILLSLPNMDIVVELKHFALDIAEQITPFLVLDSDDPLYQTLLAQLKSDDRGTILTSLRAIDRLSMSHPTETNKLGGVPATVLQNLMNWLLLNDDELMDACLDFLYQYTAVVANLDVLLQVTNVEHLVVHLVRLLSHGARRINKEIVESEAVLDVDPPSEQVCPIPKDLLERLLGIEEPERCYAWLRCFFEEDPDSNITQIAIWQAYNAAFLEPLKRKSRNMMNAAEFIRNISTVYQTAGAEIVRETGPTGETQKFIIRGIRPRPRPISPEGREYFRCLWSRVPGDPIKCGILNLTVEKMWEHILFDHIREVRGEDNKIQNREGEFACAWGNCRKYRQPTKLHLAQFMTHIKTHLRGEEEAYTAAQAKGSGAEMHSTSSSKRGSVSSSKARIIKPATTLSITFEETASVRDERNPNAPPHAAGIPLSAVLILRNIARNVVKTESEEALLKQQMKVQGNAEDDSDGTAGPGIWNERLFRPVMQRLFEVFTENRLLAPDLTSLFQLLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH62</accession>
    <name>A0AAE0NH62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Patatin-like phospholipase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_475496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH62"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="90"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3381359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="546" mass="60714" checksum="52134EE57B967AA5" modified="2024-05-29" version="1">MADVAGPREGIPPAKLPRSVSALRSSRSGAKRMPTRVSISVPQNDGPTKTDVMLQQTVVNGGTSSSSAARPATAADLSVTSTPWSKKLILTLDGGGIKGYSSLIILRALMREVARVEKTIDPKATSSAYTDRIARTSIKDEVFREGQYLPCHYFDYIAGTSVGGLIAIMLGVLGKSVDECIAEFRRQHKSIPLTNDLEAAVPIDFPLLHKRNTWPTKRTRSFFDTFAKFSVAATARKTQLAADVEASPSVSSTSSSSAATPASEPATGGRTSTDTASTIGASEFKKDTFQCQTLAWCTEVEEHRERRPYAFCTYKEEDESEKLVSIPEVAKAITTPSTFKPFKLGSGHFVDGSKQIRDPTLEVLKEITALLDGGEPAIDLLLSLGTDEHQAWFYEKLRGSGPVVAEKHSSREDISKEEGRMYKQYHRFEVTDIKLGLRKKNYLPQIEEATEKWLESEEQQEQIRRYAKMLVDHRRARASTPRWETFALGVRYYCFHEKCKANNRVFDSRGDFYDHLDRRHDLSRAAAKFTVDVEEELDKGRVFGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA9</accession>
    <name>A0AAE0NHA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_524170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="454"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="859"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="859"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3381450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116973" checksum="F91FDE41E411FAE3" modified="2024-05-29" version="1">MADISHDQSTYRPREPVPKKKISPDPRERDDAPSKGVPKNTQKTVNKPSQPPEQRRVVTNKGPSKSSFDVSASANGSAASPPGDDRTSRHGKKAQSDAPRNPSVQSASSEQNVARSQSHSPAPTSSARSASLSQPKPKFRKPISVRDRKRRIDKTKPRRTLTHYVKSRYNFFSKQRVQAEELEPSLKSLPHKDEKLLTMANETRRLFAEEIDPLTKELAETRDPKQREQLNKKLADAIGTSILMYEAKRHAVLQYEDVMGFEYACQKDAEDGKTKEVASLEVLANEILMKAKVLDRTEIYGKANPRQGVAGQMHPRFPGDRFITNGDLIPQTRLYAICRKMPKGAHLHIHFNSNLLPNVLLDIAREQTKNMYIMSTIPLTEKNKYAFDRCEIQFSIVAKKDVADKMGDIFKDTYQPLQYMSYSRFRQRFPRKLAGLDVDEWLQKKLVFQEAETYSTLQTAAGAWEIFNARTRMMKGLFNYRSAYLEYIQACLQEFADDNIQYAEIRPNFMVTNQVMSDDGTTKINNWEIMELIINGYNEFQKGITKKDKVYQEGHGKKTLMGLKVIYCTPRSFDPEMVRESLEECLAFKKDPKFAPFIAGFDLVGEESMGKPLRAFAPVLLEFKAKCAKEGVDIPFLFHCGETTENGTSTDENLVDALVLEAKRIGHGFALAKHPHIMQAMKAQNICLEICPISNEILGLTPRVAGHTMYALLANDVHCTVSTDNGTLFRSRLSHDFYQAMVGKEDMTIHGWRQLIEWSILHSCMDKEEQEKVFEKWEEKWATEFCQWIYDYRFTLLNPEFDVKDLDKTAMTEIAYDKKLEEIEAAKAAKRKEEEELAKKKKKEARAKAEEEARLRGEVLPEEKEKKDPEIVKKEAKEQRRRDEEARKADYEAQRAARVEKHRAERIRQIIKRKKKLAAAANPQKKKGDGAAKDRSGAEHDNRPSSSSSASTSASSTTTTSTTSNISGKTTGSHSGNSEKNKLNKDPSGGGASSGGTKTTPAAATGRTTRSGGASVPATTTKKLKKVNTAASGSVPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHF6</accession>
    <name>A0AAE0NHF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RanGTP-binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_209221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHF6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="623" mass="69905" checksum="251D985FC8185845" modified="2024-05-29" version="1">MDLFLASLGAQAYSLIQKRVLTFTSTYALEQCSRLLKTVNDKALRKELRSLQKQLDHKIRILSPAIDLIQFKSGRGNVFLESAVPLAKSLHREIVRLGKRLDNAATVEEGFRRPGRKASMSEAQHAELTLVIKDIRSLLERIDRDINLIQFAITASGEKLSSSATPGISMSRMMQASSFLFFGDSHFTGDPSRPVQIGPSFTLSLYMLFLGHSPPDARQENDNASLSTQKQPESVNEGPYGIQEGERKPIWQEVMHKARVRLCRTPLGWSFDTTRGYRPSRSAELGAGGISHTVSIMGSSGRPDEYSYHLEIIEDLDDGRLHEEEGPRPQPFPGMPTAGLRESIPIHQLAKLFYVDTRRILNIGNTDGDNNPILLMKRDINARSPIGIRRGWFEESSDSDEEDADEFVQSDDQTDIDRQLREEGQLSVGPADKEAVEGKEPGLGHLPPHLDPEWLAFEVFTEDYDSDDTEDEEDQESGSDDHVSDGPISLSCRPRTPQDRSSIDSKLLDQIRKVSLRATPPQEISRLSSEDVPRPQQDLPESYVVKSPFGTITSSLSLLEMLVRLTSLQEFQQTSHQAIPDHILNFFLYETSTTGLRGEAQWRMRKATKSRVGFDPYTDTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHT9</accession>
    <name>A0AAE0NHT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_546388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHT9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="387" mass="42611" checksum="EECB3D5C40A66197" modified="2024-05-29" version="1">MKSVGASSGKDYDDVTPAATLSSRLVPQLPRPSPLPDNPRLIRTAMPSAFWTGRFASVHDRFHNELLLDDNLDLIIEAQAARLRPNKNDSEPSSDCPTPSATAFNNPSISAYAPTRIVSTHLGNPGSPSHRNNHAGSNFCRPRSRIPHSATSGAIMQTPRSTYTGNMLAPLSHHPVVPPSQFVSRLPSHEKSLASPSTPRLFLPSRQSPQRRHFTLNKGTTNRAGSTATQFSAEISSSESSNDYKTLRKLTVADAEALTNDDSRCRRVFVHLEALCVTDEARQSLREWQQDYARRTKREVLLPRGGTMDDRKSGRLVERLLDVGRRSFGGNGPINNANQHGRPVIDDLAGVDDSDMNQFFWPPTSSARTSLGKGRQMGQRYDPDEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHZ7</accession>
    <name>A0AAE0NHZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_214396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHZ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="116"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="606" mass="68149" checksum="9C9D3EFB1BAA106C" modified="2024-05-29" version="1">MSFFTFLSSHSRLGGVYSLIGGHHRDVQDDDASSTGDDLENEKSIAQRPWSHPAWHRISSFAPDPSLRWGAVLLSWCSYLTCLSVLLPPFIPTVYNRLLHKKSTPATPSRPLSPTAYLDGLRGVAALVVYIFHFNYLWFPVLRNGYGSSGKDVLFWQMPVVRVLHSGRSSVTIFFVISGYVLTLKTLNSIYRGQGDKVLDSLAGSLFRRPLRLYLPIIASTAIAAVLIRFDGVFIPNIGGGDIPPRGATWQDQLWHWLRITEKTISPFRNVSGRQNLWGNDYNGHLWTIPTEFKGSLLVFLLLLAFARSRRWVAMTGVAIAAYWQMVQGDFDQTLFCVGLLLAELSIILPPALPILSRDTLPAPRIVRRCLKRLASISWLRHAVTMGTFVFSMHLMSYPELHGLSSPGFRRLSAHVPAFYKPFEERIQQFWISVGSITFILAVMYSPPLTLWQRRPTTCHNCCAQGPADSDITAVHHADSLVDVKQQPEPFLQRLFTNTFAQYLGTISYSLYLWHGSVNHIVGLRYLHPAVAAWQTAETTASATLVGDGAALVRAAALDAYAWKWVWAVVMNTFVLFWVSDVFHRLVDVHAVRLTRRISTWALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNS4</accession>
    <name>A0AAE0NNS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_471410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNS4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="514"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3384735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="690" mass="75492" checksum="D2273D45BE0C5CB8" modified="2024-05-29" version="1">MRQRKNKRPWVAQKVTPTPFCPESTAAAQDRSRDFYPSSGFATPNHNGFSMRDEARNTISHPHAWSSEAPLRRKPVAFVSAGFVEPLKDVTVSKSLDGPKADHPQGTVPESPRKNQERDGGILEVTTDREVSLRLSSSTGAATSGDVEMSTHAALGEEDLASGIVSITSPAKSPPPLFFFDLSGDKSKHNDGIFPPEIPIRQPSPVGSDSSEEIILFRGRSKNANGPARQGGRSGVPARTPKPLIAIRDEVRIVQSPIANSQPERKDSSKSQQKQPHREQPEFAPRFHEDEDDEEQQILADYIANLNAQSDDDPFSDMTQSFQVNASRELGGDHGAFNLGSENEDELAETSSGNDEGDVGEDEEGSENEALMEAEINDADLARLFTKQDELGIRSDDLAVFSGSFVRAGAGVGASRALKKKSSSSGNTAFVTEAFDEMDLMDWNPPLPVKGRRSKRPPAFNVSDSDLENALKNAWQNDRERKKNRKMGREALRADGLLGKKVNPEDLRVKYQGGMKLDDIKTELVTFLLDSAESIQFPPMDKQARRILHELANKFNIKSQSTGSGDNRRPVLYRTKRTAKYATARIMEATIHVEEATVRINRKYFPRIDTKGGRSLPREPGSGGRGGKAATYREGEIVGASAPQLGQENKGHAMLEKMGWSKGMGLGANENKGILEPVSQVIKRSKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP83</accession>
    <name>A0AAE0NP83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_472513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP83"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF32">
        <property type="entry name" value="FAD-LINKED OXIDOREDUCTASE AFOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="504" mass="54306" checksum="C19BEC5310BCCBDB" modified="2024-05-29" version="1">MLPSAAWQKVLAGAAATASSSAPPPNWNITHLFGPSLSSSASIFFASDTNYSHQVTQPWTRHAAPSFVATIQPATVGDVQNIVKIAAAHKIPFLTTGGGHGLSIQMAQVKAGLQIDLQNFQSVRFDPATELVTVGGAVKFQQLIAPLYSAGYQFPLGTAYCVGVVGSTLGAGVSANQGYMGLLIDLLEEVQLVTSDGGLVTASRTQNEDLFWALRGAGANFGIVTAATYRVPRAVNRGLVTNVNYLFPSAKKAGAVWKYLAGLDQGMAERMALNIATFPGGEGVERSLVVNVNYAGPLSEAAPHLAAISALKPLRTEVLEDVAWPDVFRTSYFGVEDTKACSRNQHVNMRSVGAKSTPDVETILAFLEEMERFSEDHPDLLAALVIHRFATQKVLDAADDENPGAYPHRDLKMHIQLEIEAKSNKKDKVMDEFLDAARQNFTKASGYDTPVVYVNFAHGDEGPAAWYGKKNLGKLAKLKKDWDPKGLFSFYDAVASEKLIKEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPG7</accession>
    <name>A0AAE0NPG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_522631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1323"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1422" mass="161252" checksum="45D4448AF6EE990E" modified="2024-05-29" version="1">MAFRFYPNVANGAEYGLIGHSVPPEPTGAQSPWKESYGGWLHPDFQSRGHSGIAPLFPEIKRPIGLGIDLQHFRSLGPLPKPTEQDLDNIFLTERFQEKVQWGHKSWQLASLNSGVEDVAAQCPIFTVDKSTWHEVFQPHHWFDYNVHVLGNPDLGIWSINNPIVSEHFDVIIEIANRLLTHALTTRWWQALVLSPRHPLEPHESGVQLGLGYDAFKEDLDDDRGKAWRFRFLGPEDVPLTAEEVEEVRLRTLELAKNIMWSLLDQDNPNDPFILNSEEFRNWFAGTSPAGIDPQFSHINVGTLGLMTLIRLDGSFHDKTPDGAVERVSLLYVYGISIFHELAHAFFQARIVGDFDTLNGEPFMEQEFVSELGNSLESYLLGGITRVFPLGSGALKDWLGPTTSGLRSLGLFQVPFPLCAEFDSEKWTLDLHINIPRIHTYRSVSVPSVLAAAAVSQDFWGNWIAKYGRERLKVDKVITSDVVYKRGKGSRHLSLRINPAADTGLLKKPIQNLIDRAEIYKHLRPWVWQNTPYANERLRTSVAVFGFAVQQGNLKDASSMVRNLEIWVDQAGEQDQGGVFIWMALARMMRATVPYDPYGTRHVIPAGKREIRDNATLYTLTHQATAAGVRLVEPAQIYAPNDPEKVWESGFPGIVKLAPGEQLVFITPCDARLRLLTDAYNCINQYRLVEPLPSMLLQAVLSLGQSLDAQIRDYQAKGNVQYRGWLTWNFTWPLWTSLEYLAVLDPATGRAGTLAPVPPNFQRKDPETIGRTWPSPPARSPTFQRHGAGERLLIKWGVLPDPKSAAYQPPPPPPPPAGGGCGGAGSKVDPDAMDLEASKAAPQDVKMDDPDAIMQGAAVLRGFHPPHPAKHWTVGEVGNHSSVPDDVWVLVEDLRDGFNVYDVSSIYATRKKGSIEKDVRKTKNGMVLHNPRIMAFIKKNRREHYRGKLIMARDLPEITERNGEDGRPLWVYLGLDVFDLTNFPFLTTTQRKLVLSSPLGNLGKVASMYPADIHFDWLQRRLGPYRVATVKEPHANKFPNMRRQEVYTVRQIKTHIFRPTGLYAVIHNVVYDLSDYVDIHPGGSKLIMDAAGQDATVAFTSGHPEKWREYLDDMERYRIGYLVPERSARQPLRWNEIALNDYVYNISILNEPDSTKDLYHKLHNGLGMYYGQDITQQYEERKLIDPCIQLLMDQPHIAVAHLDRYAMADVPADELASHYNLQRDRDTNVRGSFGGPVGWSASEIDEYKRVWTCVNRVVYDVTDIMKYSQKSTIDKLAPYLGTECRDQDIVHDLTELGVAPVVGRLVATERGKRKRPPTEDQIEEQKEQEERAKKAQQRWDLELAREDKKMFETGCVPGRPFGFLVPRDRNKEDEVVGGEREADGEEKGEEVEEYEEGQDERADEYEEEEKEEKVKWWLRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPK6</accession>
    <name>A0AAE0NPK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_181874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="21748" checksum="1ADDE72B13952C47" modified="2024-05-29" version="1">MSFFTEVAARRVATMNMSRTVATSAPRAAFSSSVTMQKSVAETAKDTLKTVDRAVSDKLVDGIDIGTTVADKVKQAAESVQTGQAQSSIASKASELQGKAAGTAKEYAGKAQGTASELAGKAKGTADEVSGQAKGTASEYAGKAQGTANQAANKVTESQGQAKGTASEYAGKAQGTASEYAGKAQGKANELAGKAKGTADQVAGKAKGAAEEAKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPM2</accession>
    <name>A0AAE0NPM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_182075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 8"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPM2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="11">
        <location>
            <begin position="187"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="12">
        <location>
            <begin position="354"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3385383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="572" mass="63643" checksum="9F3CB0232A31E589" modified="2024-05-29" version="1">MAEESKLVDTTKEQPDKQAAKALVDLSSTKLEAADSEGESGSEAEAGAAGTAEGAEEAGKKKKKNKKKKKVKQALSDAFSSKQTPEKAEADQKKALEGLTTEQLQEFMAMNPALANELISNTPGGSSSPASAIEALKKLKLQDIMTGLASSGKNRKDMASYKFWNTQPVPQFGEAAQPVAEGPLRVQKLEDIPIEPANLAIEGFRWVTMDLTDEAQMAEVEKLLYGHYVEDDEAMFRFKYSSSLLKWSLMSPGWKEKWHVGIRVGNALCAFIGAVPTDIRVRDNVLKGSEVNFICVHKKLRGKRLAPVLIKEITRRINLEGIFQAIYTGGVVLPTPVSTCRYYHRPLNWMKLYEVGFSPCPPNSKPAYQARKFMVPDKPATKGLREMEAKDLEAVGDLLDRYLKRFDLTPKFNLEEVEHWLLHKKDAPGDQVVWTYVVEDDAGKITDFFSFYCLESSVLRSAQHSAIRAAYLFYYGSETGLATPLNRGALKDRLNALMADALILARKANFDVFNALSLMDNPLFLEKQKFMPGDGQLHYYLFNYRANPIHGGITKTNKLDEDTSSGVAFIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPQ9</accession>
    <name>A0AAE0NPQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_543788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPQ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1109" mass="120625" checksum="2CC07A1777A9B563" modified="2024-05-29" version="1">MSKFGVPTVTLGELHKSGMLPVDGATDVIVCKLDFEIDGNHFPVHWLMDIETYNAARERSRWLAETLASGTKKPADGASDKEAAPSSRKKNQHDGGLPKADVPGPAPDVKPTGAKPSQRSNPATLSTRSPIPKMGGQEGEAVLLLPKPSSDTARSQPSQASQTPAETKKEEHKPNPKDPVSLPAWLTSRRPQHIETRPATPQLGPCPPSPTFFHAPPHIRTTATPVTPTTWKPSSKNDTSTNEAPKLEIAGLSTIQPKPDAATAGPSNPKPTPGTVFAGPSAAKKTGPLKKRSGVTIKDLSGQAIDLSRPGVSPTARSWHEGRPSASQRLQSQSPPWPWPPSPTSSMAVSASSSSSSSSSPVSSPSKQGDKTHDGKVVCNHLVEKPVVQVGNEKALRAGLPDKGEKNQQPPNQQEVDPQEKGRGGHEKPQEAHERDHDGDGSGGGAAIARGGRGEKCSFGTVNGCSRVYLGLGKCECVEQWFTVKGKLKNEEEEKKPETKDEVIGKTGGGTETSRDAPIPLKEPEVIMALRPGQIFSTQGNDIRKMGLNVKDYERELVAQTNKTMLEEAAKRAEKERERAEEHQVRLRIKMDELVKCQEVFKATLDKQQRLHEQAQEATAKLLNRVANAPKNTSKLPYNNKALADAEEATRRRQIIIERQKRLQLGSKQLPKIDLPGMEEPEIYDSGSSPAEEEEEEKEKKAEEESSGGGGGFVSSCKPGAARKLVKWPVKPKQPLTTKLFESKKLEYPNPAPPLPISHLPPKNMQLPHDTYNTAGLGAVYSPTDELFQDDEQPWGGPPPFPVAKFLPPLDESELKRLVSDENMRMIDAPNSTIAANQLHSAKYACRMETPKDAAPMPKPIPIPISKPVKKPEPQAVAVAEEQHVEPSAPEIQVKSPAGECNHVVANALGAPESTTISSEVTPEQKQKSETVHHSQLPLGDSKATLVAELEGKDYNKAEEDLNKKNKHHHDEAEKEKEKDTKMVLNNSLRDSGPSSGPSPGPTTAAGVGVGVGVSADWEIWRQAPNPTRWLYDPDKTPPSTFMKYELGEEEEEEEEVEVVARGELPDPAAAEEDEWEGFTDGMEIGCIENGRRLRRRRIHNPDTYCRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ81</accession>
    <name>A0AAE0NQ81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_393969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042124217" description="Protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3385559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="355" mass="39659" checksum="2672F3572019E487" modified="2024-05-29" version="1">MKNWRAFFGLPVLLAGQALAWDHITEPGSLKAAIQANEHTLVACELSGTSHEKNQALETEWTKIQENEEGSQVVSVDCSQTPKACEELGVSSFPAIRLYHRDGRLDRYRGPRKTAAIQGYLRRALRPTVSHVTKKNETSFLLADDVVFVAYFAHSDSNLRERFAAVANKYRDRFSFGLSSDNDGKRQESILTCHNNPDQLQRSIAELSTADSLEGFVKLCATPLIPELTRRNEVSFYQSGKSLVHYFVHNDKQRDEYVTEIRPLAKKYEEYLHFTTTDADEYADAVAMMGLEPSVGGLSVQNPRNGDVFPYPGRQRLTAAVVEAFLVDIIQGRVQPWTGEHGQRGGQGGGGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQC9</accession>
    <name>A0AAE0NQC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="248" mass="27614" checksum="78C504F1BFAFE748" modified="2024-05-29" version="1">MASQPLSRPPCSKGAKDLPHANDSSSGMNEDCVPSSDDESLSTASSSPVPSGQAREEPPAPARIRLVEAWSDYYAAIGVAPDARFRTIRRMVTHRLQFGLVRGAWAWYDPARFIIIARGIQILTPEERPEYDRLRDEYLTSLGDLSDPATLEKLRSNAEANVRAISGHPLGQKLKKLGDDWDAANRVVVSLKELRHETALLSKSENVNDRNLAEARRQSLAVNRALKEGLWQKIETTIDEIEARIDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQY3</accession>
    <name>A0AAE0NQY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_523377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQY3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="826" mass="88749" checksum="30C3E771B7E3CC4A" modified="2024-05-29" version="1">MADPISIATGVLSLVSASFKITESLRTLKSKFQHVPQTVAGLATEFQATSIGLSQLRRFLDSRQHVFSASDANEVERVYLLQCLDATTFDMAKTFSAVDAELTKLNRDDARQSIALRMRFMWVEGDLNAYMTQIRDQRSSLVFLMQSIQLEGSSSKIDDIHRQFQSDSPGLSALKRTTTNSKAKLQRRSTMMQPEPKTAESCASDLADMLQQETKTFPDLSNIASSEKQEAAPQQQQASPEQEEPRHANADPPVSSFEGLHVKDDSFSRPTSGSQHVQPALVFHELHLSVANDDRSRVLACLQAGHDPLGLPRDPYGSLPNSKKTSFALAAYLGRDEIMELFLQRGFAKALNETIGTDLPPLLCAAYSGHQRMMQRLLDAGATPRLQGPGGSTSLFWAALKGHREVVDLLIRRGAKGDVNQPNAKGLTPLMVAAQHGHHGVVRVLLSHGANIMAQNMKLQSALHLAAHAGHPDTVGVLLAHQAPTNSITSNGKTPLLFAATSGHYDVVALLLLHDAFVHAQDAEGKSALYHASCCGWSEVVELLLAQGASKELVTQQGDRALHIACEKGHVKVVGVLLAHGASLAATRAADGRSALGIAISNRRAEILGPLILFHTQQDPAGYTKEMALWTAAEWGLDETMDALLEAGANIDIRDLNGQTPLGRAARESKAAATKLLITKGASVNVIDEYGATPLHRAARTLNVRLAEHLIKGGAELSILDKNGYSPIHLAAIYGTSEMLEFLAGHGADLECMSASSKTPLVMAAENSRVDIIQTLLALGAVCGYPNFSISSGPGDVLFVVDREGNIEVVVETIIKKFAPGPGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRM3</accession>
    <name>A0AAE0NRM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_136343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRM3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="165" mass="17974" checksum="6ED1B3180E6EAAEA" modified="2024-05-29" version="1">MARHQESASPGAARCVLCHQDEETKMGERAAEVSAGSLSLPPSPRNLCNYGRQRAGLSRQPPRYPSPSHRLCDMTGDEAGQSGRQLAPHGRSPRLLWRLASDCAHSLLPPLISLPSRILLQPQRQTSRHLPICAREPAQTLSVLVVQVCVLLYIGMMSIPVSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRQ1</accession>
    <name>A0AAE0NRQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRQ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="74" mass="8507" checksum="52E272B66D4D27BC" modified="2024-05-29" version="1">MLTNSTANSVPEAVIVHSKPTCRTFHYFPDLPKELRDKIWDMALRPGRPAAHFFTIFDPNDGEDERYEVRSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRR8</accession>
    <name>A0AAE0NRR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_447424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRR8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="30434" checksum="87E5ADFA372179C4" modified="2024-05-29" version="1">MTSKARDKPDCLGYVRTGRTCVPNDRSHLLTSSSKSSSIASYYCIPFRVPGSQKDRQLLHFFYVQGAADASQYNAVVRLALMAPSSPHMDLAQIGGASSDLHHHHHTSDYSGIERGAAADGVATSTLTRYGTGRRFVRYKALSLVREWKTKAKRSKAAMRHLDSGLRVFSSRKSNRRIANRGDDFMLAKMADVLARLNLQASFLSSGRIPLLALVSAEERAMAMRGGEEEHAFSGLDDAHLDWIRLQNWMFRYLLSENVEISAAVLEEKEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRU7</accession>
    <name>A0AAE0NRU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_540478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRU7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="46005" checksum="FF847D7624E8DBC6" modified="2024-05-29" version="1">MTTEEPQWDAVTEAEIALKKAFSDLKVSGDSALVPGTDTTPNRFILHTKGYYDLRAYVLSGKEFPRTPAAFQAKMPKAAFAKLTAIDSTIYDKTLETMVAIGSTCTEYHNSNLAKLVTAATEAANFSDNTIALLSDAEGINLKDHLNVLLDPKYKGSTTFDDAFYESKEAAQFTLTLLKADAEEKELEVKDVINTMIAFKENTMSQLTSVVFLDRQYNTGPVTNSSTVKTPYVQYLNAELATAISSFYATLKQAQDVWGRYEKARDIAIGVAFVPFGWIGSIIKGQEATNLQNEYNALIAKSTRLQQEWAEGEALINLVTRLTRQCDDIDDKMEAAIDAMVELAKLFTAQAKCYDGISNNLDGMHTGTDALAAANRKAYINYNLGECLKRLKELKLLAEEFAEAIIRDVSLTTGDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS17</accession>
    <name>A0AAE0NS17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_392977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042075112" evidence="1">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="311"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="47055" checksum="6B647416DE5BF4F0" modified="2024-05-29" version="1">MKSISCITAALLVEGALAATSGKFSILSMNVAGLPAILNQNDVPGDKTTNALSIGTKFAQYGFDVIHAQEDFNYHASIYQTDNHPFRTATSGGVPLGSGLNTLANLDWVDFKRIKWATCSDASSSDCLTPKGFTFMRLVISGSTDNTTTVYADVYNLHADAGTESADNVARQANINQVAEYIATWSKGNAVLVFGDTNSRYSRTADTAIRSLLANGLRDPWVDLQRGGVVPSVETLCANPSSNNTCETVDKVFFRSSPLATLQADAFRYASSLFLQADGNILSDHNPVNVNFTWSSGSSLRQSKFWGGPHGNWFSDATTLASISKPKPATLTFRGGSRLDNVGVTLKDGTALTHGGTGGTAVSLTLGTSEYWVEAQLCQGQKDGWTRVFYIRAATSSGRTVSSGTATVDCMSFSAPSGWQIVGFLGQAGDEVDQLAFVYAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS95</accession>
    <name>A0AAE0NS95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_140311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS95"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042235381" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="18703" checksum="6BFA42D6496AC477" modified="2024-05-29" version="1">MMDKLTWVTAALLVLAVVAQDTRPITAIVGTHCRTDADTQSTQDACFRPYLPLYSSCYNSFVATASQGDPGVLQCICKFNLAGSACWSAACDATGYSLYMDSYSSCGGLGVGGPVPTAPASTNAGATTQTPATTPGPSLASTGSGGADGGGAAPSAPTSTKSSGGVAYGVGVSVHGGLLAGFVGAVAAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSJ0</accession>
    <name>A0AAE0NSJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_140271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042214647" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14147" checksum="83A2520D2CF60C27" modified="2024-05-29" version="1">MGGSGTRKRGQPFLARQFLALSLVLAHQSAWPCRHCTMCPVTLLHFQQKSHSHLAYPFGLFLSEIASMESTPMLSGSQSQSLWGKLDMESSRRSRGKSVDNSHHAALVQGPPQQLPLYIPLLAPVPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTW5</accession>
    <name>A0AAE0NTW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease/ribotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_509415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTW5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038684" evidence="5">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="175" mass="18785" checksum="912FE42E20F99F19" modified="2024-05-29" version="1">MVQIKSSAMLVVSLMGSMGLTAPSNPPLATTTPMNETINGTSTVDRSAALAGFKCHNTIYPGGIRFNSATVFGNVAAFPSSGEKQASGYPHEFTNFQNFVWKFNIWACSHHTLYEMPVFSDGSLYKWDKKRDGPGGQNPGPVRAIYTRPDDGKDFCGLVAHTAGNAGPFALCDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUM9</accession>
    <name>A0AAE0NUM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 2 sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_542548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUM9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="242"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="364"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="710"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="783"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3388006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="888" mass="98666" checksum="BD718BC798570345" modified="2024-05-29" version="1">MASFHWTLTQALATGTTSKDLNSPRERINIYDGWRFQRWAESPDKLAYDKRSDITDERQLLKPWVLPSMNDFVLDPTRRHPIPTTSPDLSSVPFIQKNFDDSAWEHLSLPHDWAIKGPFYTEEVGPVVGGGMGRLPVQGVAWYRRKLTLDAADKGKSIFLDIDGAMSHAVVWVNGHLVGGWPYGYTSFRLDLTPYLEVGEGNQLAIRLDNPVASSRWYPGAGIYRNVWITKADPVHVAQWGTFITSREVSQTSAMLDLQVRLENKVNDTRELKVTTTVYEFDPSTETAGKKVATFPPAAVKIQASQTDSINSSVKLPSPRLWEPRQNQDASLYIAVTQVYSNNDNLIDTYTTRFGIRSVTYSGDNGLLVNGKHVRIQGVNQHHDLGSLGTAFNLRAAERQLETLRELGANAIRMSHNPPAPELLDLTDRMGFLVINEAFDCWEVQKNPNDYHLLFPDWHEADLRSLLRRDRNHPSIIAWSIGNEVGEQYTDVAGAAIAQRLTDIVHQEDPNGRPSTASMNYAKPDMPFPAALDILNLNYQGEGIRDTPAYAGLEGIKTPPLYPAFHAALPEKLLLASESAASLSTRGAYLFPVTNESSAPQTNLVGGGGDPLLRQVSAYELYTAPFGASPDKVFSVQDNNSFVAGEFVWSGWDYLGEPTPYYTARSSYFGIIDLAGFKKDRFWLYQARWRPDLKVVHILPHWSWGAERFGKVTPVHVFTAAEEGELFVNGRSQGRRKRGGSEYRLRWDEVIYEPGEVRAVTYKGGKEWARSEVRTVGEAKRLGLRADREIINGGAKDLAFVTLEVLDGRGQVVPTADHLVTFEVVSGPGEIVATDNGDPYSMVSFSSKERKAFNGLGLVAVKASRPGRVVVKASARGLVAASVTIMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUR4</accession>
    <name>A0AAE0NUR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_470957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUR4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042203800" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="428"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="549" mass="58501" checksum="D27C92B2A0F9D0F2" modified="2024-05-29" version="1">MPSSLLLSVAVSLSLVVPTYAGFQVQCFSRLFDERLDPIVDPGKLSKHVHVIAGGNGFAASMDFDMARASSCTTCNVRDDLSNYWTPKMYFHAQNGSFIPVPIVGDNQYGNMGGMVIYYNDNRGDTPNNHIYPFPPNFRMLAGSPMKRNATSDSAGRAVHMKCLGDGGNVDYPGFPPRKCSGGIRAEIVMPSCWDGVNVDSADHKSHVSYPVGVVEGGTCPPTHPKRLFSMFYEVTYSTEVFQDMWYDAQQQPFVLASGDPTGLGFHADFLNGWDVDVLANAATACQNTLVQNGNRCQPGYTGADAVLRHMTNQGEAFACKLPSVSGEKPNASVLDTLPGCNPITDTEAAARSVFSCNGGTAPSSVSSPSTTASTIVTSLTASPSTSTSPTTTTTTTTKFSSTPTQTGSVITIPVPGGGSFTDATSLGFSYVGCASDDPANRTFGRTNKWVGWPDMTVQKCIAFCQADGHLFAGVEWGSECFCGQTLPADRQPSPANKCIKPCSGDAGQTCGGDRAMSLYKACSQGQPCVNNQTPAVRRRRRRNFNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXC0</accession>
    <name>A0AAE0NXC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_445547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXC0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="245" mass="27738" checksum="54B8CC0340CD5CF7" modified="2024-05-29" version="1">MSHKVQWVEGHIAFLKTWESFSSADYDHLIGTGYLPQKACQHPVIILKRTATHVLVTTVSAYSSGEHDNFCPPWRQQYHQGKTKTDFRSFLGSERCGVRPFLYLEDGRVMPKVRSSWVYAQNAYVVPLAVIGRLDKVPGLLKVRSDSLADLLQHFSESWQCFPNLLSLFLSLFLSLFLSLFLSLFLSLVFFLPLVSAVALFLFLVLFLPLVSVVALFLSLLFSNLTSAYVPPHHRTWASVAAIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXE7</accession>
    <name>A0AAE0NXE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_390787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXE7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042193418" evidence="3">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="485" mass="50785" checksum="BE13BD79FDA9C848" modified="2024-05-29" version="1">MHSLATLCLLLPSLPLVAAETVLGAYVFHRHGDRTTKAYSPVSLTSLGADQVFTSGSWYRDTYISANASSQINGIAADIPVLAQLSVTSSVDNVLQNSAQVFLQGLYPPAGSAAAQTLADGSTVQAPFNGYQYIPVNAVSTAASSKNSEDNVWLQGGSGCANAVTSSDNYFASAEYQSSLETTKTFYQSLLPVYNATFPSDKANFKNAYAIYDFLHVSKIHNVSSTIPSASLLTKETLHQLQTRADQHEWGLAYNSSDEVRGIAGSLLAAQVVQALNATLAAPISKAAAQRLTVQFGPYGTFMAFFGLTKATAASSDFYGVVDYASSMVFELVTNASLATLKPADVSVRFRFANGTASKTNPPRAFALFGQAEITLPWAIFAREMGKFAIGDTASWCKACGHSSACTEVSATGNDSGATSSIAAGVSSAVSNAVAGVIGALVTLVVILGLQGLFMAIVGLRVVKRSNNEPLAVKKSGESDDVSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXR2</accession>
    <name>A0AAE0NXR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXR2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="355" mass="39934" checksum="F40713B9CF9CCCA8" modified="2024-05-29" version="1">MESKDTSQPKPMNTPAPTISSRADACVDLFKKCLGKYKSSAEWYPRIMTSAQTFWGWCECVQARAPAHVEASLDARLSFPNHEQTRRCILGALHVLQAQLEGELSAPLANPTAVFTFGNVESLLEQLSTSVQALEPRPLWPIVQPEKEEKSKGKGKALPAPAPAHHSDPRGAPLYFQAKRCRDLLFEMFEHCFPFREPFRSVVQSREKKFDNWVAYVVSVGVLAPLQASRDPRLAPTPQDSLRTRIQGVLTDLESILEHRCQFMRQPDWPRRPDAPWVTSVKQGSWNLDGRDFAADMRWHVDPIINELCKIAGNISRSSSTPEQHEAGPSRHIAPVVSSNPQDNPFWKQVSRQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXS1</accession>
    <name>A0AAE0NXS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_556722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXS1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="48240" checksum="13723A79EAA3AC92" modified="2024-05-29" version="1">MGFFDNLEDEELGKRFLAFPVINSTRVWDAESGQSIKTLYRIVHDFDQRRTLTVFTATREDAEDKQFVLEALDKIVDTPKIAQPDVIAITLSEKGTLRSFSTNMDHDHTMIPCYSLIQDFHALLPNPPTIRRSDLTEVDRLGIQADHVTYTPQLGQPPKHVAFKYYFTEIHRDSFWLEISTLIQIPRHPNIVPFDRLVVETVGDKEKVLGLTTPFCGGDTIDEQPSVVFTLAHLTQLLEAIDYLNLTLGIVHGDIRTHNLIRTDVHYAVITVFDIITRQAAERFDGLFLHEVNRADILSLEKWEKHPSVALDSDHPGDTEPYRQALKAWVEKRDAIDEKNFILTHPIKWIPRPEFPEVYHFGSMQRVGAQMRQVIEPRGDPFPKWHRPPSRHLPLQTGKVLLATGEVVGQRRSERQLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY50</accession>
    <name>A0AAE0NY50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_464510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY50"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="32593" checksum="E4549C7F217C9637" modified="2024-05-29" version="1">MSAQDYYGGGGQPSQQPYPPQNQYAQSPYPPAQSPYPPAPSPYGSQPQSPFPQQPQYASGPTSPHPPPYQQQPPAYPPPQQQQYPPYPQQNYSQQHLVPYGAPPPRPGSANSDHSSAYPPPASYDRPHSAQSGAAAAGYPGQQTYASPPPPQQQQYKDTSGPTSPYPGGQHPPSGGAPGPDGPNGEKGFLATVGGGAGGAFLGSKIGHGGTMSKIMGGAAGALAANFIESKLKDKKHGSSGHGGGHHGGHSSHSGGHGGLGGALAGGGVGGLLGGLIGGKKNDHGSSSGGYGYPQQQTYGGAHGQHGHHGHHHGHHGHGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYS1</accession>
    <name>A0AAE0NYS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_464774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYS1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34259" checksum="505967EAF6EF3A57" modified="2024-05-29" version="1">MASSTSTATKASLEIPSAEVTRKWWVEDAELTIEARNLLERYSGLTDSEIDTHVRALREKIWAVFPYPCVGSFDFATPNLSRRRPLFDRLVSILCAPTSLTPSAAKEPLYLDFGCCVGQDLRTLRAAGVPGNRLIGAEYFPGFVDAGYDLFLDRDTLGATFLTPYDILDTDNRSLEPYQGQINVVHMGMLLHLFTWAQQVDILVKKLVDTDTGIFLKDTPGVLLVGTVVSHERGVATESWNTPGHWPFFHNPDTFKRMIVEVGERTGTKWQVSAEYDYRNNFTKPEGLEGRDEIRQLAFECERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZP8</accession>
    <name>A0AAE0NZP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_519901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="49291" checksum="C290688AB47C05C0" modified="2024-05-29" version="1">MAALATSLAENLRLSVQAPADPVGGPSLSPAQAREDNGNKLKIVCYVFAVLSPLLVGLRLWARTRTVHGVSWDDWAIVAALAFSLVTTGLTIAQVDLGFGRHVQTIAPSDLRYIEYIFWWVEVTAIAPHMTKISLLLLYMRVFDHVRWLSRTCVGFVIFIALWAVVQVLLFVFQCWPVQKGWNPLIEGTCLLVEDLFYLRDITSIVIDVILMFLPIHYVWKLRVPQSQRYALFSVFSLGIVTIFTVAMRIPTIPDALGDTDPTFNITPGIWMLLEIHLGNVCATLPTLRVVLVRILPEIFRSRSATGAGGSGSNSLGGGGPGHHTGTGTRTSNRNRSSRLSLSNPLRSTRSGQGVFTQSSSFLRLEEDDNAIEMDRLRRLSRAYVRTSQIRASRSIGNGLRMDPGPNGIVRTVEFDLEIEETSPIEETASARMHIQRAATIPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZV8</accession>
    <name>A0AAE0NZV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_466332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041958558" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="262" mass="27963" checksum="7E38A552FBDE941C" modified="2024-05-29" version="1">MFIHSSAFGLLGVAALLMPTASGACTREGLLAAANSYVEAVAAGKIDGLKLATSNFTYQENNKAADIKRGVLSQPLKIDLNRSTADTTACASYTMIISSGGPKPYVIATQIRHPGDDTSSISMIDTIAATTGSLFFNAKKTLGYIQQENWGTLAEADRPSRELLKKVGDSYLDMWTDAKAADSIPWGTNCERVEGSQLTKPCGGSLPRGGSSKNNIDRRYVIDETIGSVDILCSFQAVGNYPDSHEVRVEAGKVKYVHTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P083</accession>
    <name>A0AAE0P083_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_129599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P083"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123437" checksum="CC1F7121BD8908F6" modified="2024-05-29" version="1">MHQGPTETSTQDFQPNSSQLTSPIAQHGSNRPHPGSPGARSQSSYTGSSSPGTPRSGGANGVDVGQLDRRLGRLNVVDGHVAGQRISEYEKALAYSNSRQKSPRPSLGFKVVKRPGSPSNGAQLTDFPNEILTHILSHLHPDSHGSVALVSKRFYALVTTPYAWRTAFLRYFPGQDALETSEKATQHAGDAGLSDTIRSEFRYFSRLTMLGSWRSEYLLRTRLLRSVARGKPGSIGASTRSSQTGKKASAVLTYNSKLPWTITNIHASFASGKRGPRVVHGAADLSVASVSDPMIGKVEKTGLDDPFSFAQLDEVFPDLEPYGVGDGPAAVPNVMDVSQPYGFVGGEGFPGGRAYFRASGESRGRYLGQDVAIIDMVPEIPKIPEMSEAISSVWIAKSSSLPSMTQSMVGILTGSTLGVVTSYALRHDSTGPRYANGDMTARWILSPGVPIVDIKVDDSYNQKRKARNRVWAVALNALGEAYYLTETPAPPLVRAKAETAVKDAWYTGRTVYWKLIESTRRQPQPDEFDKNAVRGMYSPRSPANSMNLSKGQIVAEAQEIEKFLRHKPTHFRSACLGWDMRRKLEVDFAGGDEIGTGEAIFVINCGHEKGERASVRRYLRASEGAEGPTPTRALTPVAQSEAEVVSLFGGVSGPGQPSGSKAKETVPAPQLAIPNLSAVDVDEWRCMEFDLGSHGNIEITASAVDMSTFALLAPLEDPLLSASQEPGPNTPTSKHAKGEIPGRRSRSLAIGTNTGSIILWNMRDTLPLVAKPIRVIQTDSPSISSLAVSALYLVHGGSDSLVQAWDPLASSLDPIRTLNARSSGRIPRHILNANPALENANYFVVGAIFLDPDPTVLRGVLSFGTFIRFWTYSSTGQSPGRKRRLRHSDIHGRLASRRNGGAVSSYIAAEEEELRHEQEHRSREIARLQSRFGVGLGDLTEEEAIRYAQLISEESFFLDEQRRWSASDTGSAADVGDSGSSADSTDTITPEPSVSGASPSTQNLPPLHEENEDEYEAQIQRAIRLSLLEGVNDAGVSPTGHSSGEYEFQVKVKVKPRDKKQWKRSASPSTASAPAVQSDQSDLGLGVDADDDLALALRLSLEEEQARQSRASNAIGGGSHYQEYQEYPPLDVNGKGKGKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0V6</accession>
    <name>A0AAE0P0V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041957395" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7896" checksum="58D790934FF62AC0" modified="2024-05-29" version="1">MHGGFLFVSPLLLPGLRTTHQKQAESCGRVPRHGRALWKPQGRFHSAIGEAPGASTPVRLPKRVTVFPPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P464</accession>
    <name>A0AAE0P464_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_11699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P464"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="427" mass="45090" checksum="2360E3297485A27C" modified="2024-05-29" version="1">MSHAQQPSIRSFFQPRPPVDSTTTTSIVPPPTSASPGVAPPSKLNHSASVSTSSPPPPPPPQHHASPSTPTVALSVSPLPGGVPVLPSPPSLPAQVSIVPVGEQHIAALRRINSLLLPVAYPDSFYAKALEPLASGLFSRAILWQDDGIGRPGAGPRADPKVIGGVICRLEPNPFLDANGQPRAPPPPPRLGTSQQSVPPRLDTPYHAVYIQSLTLLSPYRSQGLAAAALEHIVASAAILPAAGSSINVRTIYAHVWTENEEGLRWYESRGFRREGCEPVRGYYFKLRPDTAWIVRRDIGELGSPLPQRQDPSLSSSPPLQAEIRRTSPSNSNSTLAAAVNLAPMGSVPPPAPTRPSLTSSSASSFQNLRPDMEWNDLPDDMVAGAGPGRSNQLVPPSLPGSGASSRSSSAVRKKKDRSYPTAAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P504</accession>
    <name>A0AAE0P504_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_388142</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P504"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041772155" description="Peroxidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="125"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="100"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3393394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="371" mass="41335" checksum="F54FD5701C3485F8" modified="2024-05-29" version="1">MRPPSSAAAWVSLLLLPKVLAHPGLDDVLLALNKLDTAAAAGCWESTELIGDLQWLNEYDLYPTARLIRDVLRGEASGQSDEYNYHVPPLHSPACAYDTCCVWQYIADDMERAFRERNGECNNAARGAVRLGFHDAAGWSKYTGQYGGADGSIVLAPEETERQVNAGLREIIDQYKFWFERWRHHGVSMADLIQMGANVATVVCPLGPRVLSFVGRYDNWNPAPDGLLPSPFDTADNLIEIFRAKTIQPKGLVSLLGAHSTSRQRLVDPSRFGAPQDSTPGVWDTLFYKQILGPSPASVFNFQSDLVLSRDPRMFPTWKAFAGPNGQQFWDEGYAREYVRLSLLGVYNINNLTDCTRVLPPAKRSWGPEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6J4</accession>
    <name>A0AAE0P6J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">B0H63DRAFT_498921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6J4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="393"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3394204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="821" mass="92006" checksum="69ED418C37328EAB" modified="2024-05-29" version="1">MALLQYRAPVDYDAQQAAFESFLSDFKTSPEQTITTALGNINIDEDDLSDEYDFMDEDDDAQQRRQRERAQKRTPQHKYKDMLQLLADRKLDEVVIELDDLQSFERDVNEGLKLVESVENNTKHYVEILSRAVDKLMPQPSIDISFKDDVLDVLMANRQQRNRDLEEVAERQMDPTIINEQYPAQLTRRYTLVFKSRTSTPDNPVKALSVRQIRGDHLGHLITIRGIATRVSDVKPMVQVSAYTCDRCGCEIFQPVTDKQYGPLTMCPSQDCKDNQAKGQLYPSSRASKFLPFQEVKIQELAEQVPIGQIPRIMTVLCYGSLVRQINPGDVVDIGGIFLPTPYTGFKAMRAGLLTDTYLEAHHVLQHKKAYEDMEIDPLVMRRIAKFTQTGNQYEYLAKSIAPEIYGHLDVKKALLLLLVGGVTKEVGDGMRIRGDINMCLMGDPGVAKSQLLKYISKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDNDRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPLYGRYNTRLSAVENINLPAALLSRFDIMFLMLDTPTRDTDARLAKHVAYVHMHGKHPDLGTEDGVVFTPAEVRAYVAQARTFRPVVPSGVSEYMIKTYVRLRSQQKRNEKIKSQNFGNTTPRTLLGVVRLAQALARLRFSNTVTQDDVDEALRLIESSKESLAGDNANSNRRAPNASSKIYNLVKGIADSGACRANEDADDEDEEDEFGIELSLRKVKERVIAKGFTENQWLTALEEYTELDVWQTAGNGTRLVFITSNNAERNESSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6J9</accession>
    <name>A0AAE0P6J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad1/Rec1/Rad17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_460411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6J9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000014">
        <property type="entry name" value="DNA repair protein Rad1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="38055" checksum="F221D33BA3A31DEF" modified="2024-05-29" version="1">MASSSLDPPPPLFRAVCSSTRPLYQLLKSIGFTNKIHVEITESGLRFAADHARVMQGVAHWNKSLFTSYATNFPEPAAKGNKENDDEEEAEDPPTPNFQVSLPALLETLQIFGAADAAARQAKNDADAYRSNLRNYRPDAFSNQTLGMTGTCSISYAAEGEPFSILLEEAGVKTTCNLTTYMPESPEDIPFDIEDLSFKVITQARWLLDALAEITPTAPEKLIITVSRREPYLRLASAGAASFGSSSVDFAKSRDLLETFSVRNRWSQTFKFDTIKSATEAMRIASKVSLRGDGQGVLSMQFMVEVEGAGPSFLDFRFVPYAVQEGEDDDDDDDENGDADENVARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6N8</accession>
    <name>A0AAE0P6N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_41328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6N8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="195"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="302"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="460" mass="49133" checksum="1F86A367745BF886" modified="2024-05-29" version="1">MASSTILLSRTLARSAARPARFSTTAAAASVPRQSPFGPAPTPITTAAPTATAASRRRQQIRHASTSKHPQGFEPPSPDDLAELRERVQEFTRRELTEELAAATDRTNSFPNNMWAKLGDAGFLGITADEDVGGLALGYQAHCVVMEELSRASGSIALSYAAHSQLCVNQLQLNGTAEQKKKYLPGLIAGHKVGALAMSESGAGSDVVSMRTSAKQVDGGFVLNGSKMWITNGPDASVIVVYAKTTPDAGSKGVTAFIVERGFEGFSCARKLDKMGMRGSNTGELVFENVFVPQENVLGKLNGGVRVLMEGLDLERLVLSAGPLGLMQAALDVALPYAHTRKQFGTPIAHFQLLQGKLADMYTKLQASRAYTYATARAVDEQGLIKTQDCAGAILYAAERATECALDCIQVLGGMGYVEEMPASRILRDAKLYEIGAGTSEVRRMVIGRAFNKEYAYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P708</accession>
    <name>A0AAE0P708_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_49047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P708"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="92"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="975"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120691" checksum="7328EDDB185E43D1" modified="2024-05-29" version="1">MPTAWNGSGCCSESEPSGSLHIREVCHDTRRLRHTKARAQSPSGAMGPIDVCDRRPRSRGAARRSPRPGRPVLSLASIAAIALSLGGLVQPASAARVHFENCLQESYISHTPKPLQWTPMFVNASFDTTSPSHRLRVIMWGNVEGSYNNVSLPPSDSPDWTDPTKLDGKILDEPEPDSPSPKLTTLRTKIEVLTYEPWSNNTNFCNDSLEHGKCPLAPVFKVNSSIFTPDELPFVTMSHDLESSYAFTSFSATFLIIYGDGAGTNIGCVSAAITPDLGNLAWMLKFLPLVVLLFVAGATVFAGIFSPWGTTDIFHWSSNYGRDADLLRLVTPGFGDCLQYIQFIALTGGLTLNYPGFYQPIVSQASWSVLMFNQSFVTKSPGRSSLQDGIYVTDGEYGLQDLAQLAGMGNAEDIWAGMMIWLLVIIAAMFILVQGGFAAQWIYRLVRNIPEEDLRAKNIPFSLGNVVRIVLNYFLLPIVALSAFQLVIAGSSPAYTVALAILTLLLIIAFASWLFYLIGTTKPRAFLFDDLPTVLLYGPLYNTYSDEAAAFALVPVLLLFLRGIAIGAVQPAGVAQVVILAICEVVQILTLHAFRPFHSPTSMNAYHTLFSALRLITVLLMLAFLPSLGVTEGPKGWIGYVILLIHGGVLVLGFFLNAVQTIVEVVARMLGAGGDDIRGQSRGGLSKIFGMRQLSRRMSRREAGPSRQSQLSSSAMLDAEDASKAGFVMPGGRLRSESAGSMGILMHRRHRSSSGLDHLSLDAPVRNIDSGASSFTPTTPGEVSIFSFLPSPGPQALHQGTLGMQANDPYYRPPRPRRQTVVDPSPSPAAKTGGSWMSAEWSHKRLSQGATAPIGDLPDIDGQPSRDVTPAPYVQSTVPFAPRADYSTREVDFYYGVRGPRLNTDAPGRKLGTGPADPTGPMASAAGWIRNMFGGKVKEKGKGFEVVRSARMPPAMRARAVIEDEAPPDGIPVAMGVLRNGPIDSDDDDERHSLKGIPSKHSMAPGGQSPAGARDDMVDGASATMNTTYPSSVVTDDQPPLPRKSSKRPPSVSLIPDAQLSELRQLTPTVSTTSRLPFERSQARRSSSSAGATDNLSNTDLSEPPVVLDGRTTNYGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7W7</accession>
    <name>A0AAE0P7W7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal L29 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_385143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7W7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="120" mass="13833" checksum="21D1551D2C16FDE7" modified="2024-05-29" version="1" fragment="single">VKAAQLWTKSKEDLVKQLGELKAELGQLRIQKIVSSGTKLTKIHDLRKSIARVLTIINAKQRAQLRLFYKNKKYLPLDLRPKQTRAIRRALSKEDASITLLKTKKKAQHFPTRKFAVKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVL6</accession>
    <name>A0AAE0TVL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_495027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="363" mass="39091" checksum="185356A30CE2BB76" modified="2024-05-29" version="1">MESNRDIPADAHTRHVFYAGGEYVASEDGNARSLQGQIYVEHLTPIGKPLNKYPIVFIPGGGRSSVDFLTKPDGNPGWASFFLARGHECYLIDPAFRGRSPWSPSRNSKYHVFPAELVAKAWTTTTTTTSPLYSAQSQWPGTGQPGDPSFDGMYASTFPSLDDIVLQQSTTQKSCAALLDRIARPVILVGHSLGAPVAWLVADVRPRLVKAVVAVEPAGPPFAGLGASGPRAVLSAYGVSDAPITFVPPVVDTSVDFVLTRVQGNGEKGQKEVLLQVGDDDDKPPRQLVNLVDVDVLVITGEASRHATYDWGTAAFLRQAGVKEVKHIMLGDMGIRGNRHMMMMERNSDQIAGLVGGWVDELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVM1</accession>
    <name>A0AAE0TVM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aflatoxin regulatory protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_197661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVM1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Aflatoxin regulatory protein" evidence="7">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="40246" checksum="C94F78DAAA10680F" modified="2024-05-29" version="1">MACRCALERDGSSHHILNSLPDTPEDLTPPSLYDFEFDSCMHDLVTPDQLQLSPAESHHDCSHHDPGFTTNITFAPLYSYPLPTAQENPTTKASPFKSTQQRQSTNYCLFGSEPSGCLKIGLKTLTTLSTAAPSRICIFSKSFMLDPHKPRFVDAALSANRDAMDSVARILDCPSCLATPTAHMVVVSICDKLIAWNQAALLGAASTPEEEDMPSFGHHPLSSILYSGAEFSPISGSEGSTPLGGSSDGGYNSTTSATSTCETRRLDKSRRGGRQSATVRVGDFVLDDALADQAVRCVVLHDLDRIEVLVNRLAVGGSSSGGGSSDADHHQPFKRTVHQSLVVLLQRRLHAARSTMLANHSGTMWSAAALLGYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVZ8</accession>
    <name>A0AAE0TVZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_511408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVZ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="229" mass="24415" checksum="DE1B286F605A272C" modified="2024-05-29" version="1">MTCGSSGERKQEAELDDVWGSVWWTAYSAGWNGRTMETVDREVKRPGPAAVGSRAGQGRAGQSARRSQEHGWESGGSTAREVRMEDGRHEGNSGTKSGKAAQEGSAQYFATCPAEGTGQGSRQHKKTPTAWLLPMCSKMMVATQATKTGRDSSMGFSSSEERSRVASVGGRRKSAQASAKVAAKSVEGVGSVCQCGQCSVQLARDKASVDEWWEKCTTPHASAWASRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW20</accession>
    <name>A0AAE0TW20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_495164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW20"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="430" mass="50796" checksum="B0972EB61545DEAC" modified="2024-05-29" version="1">MLRRFLRGPSPRGGWIARYCRFPLVVLLLAAMAEVWLHRRHWAVRQPEHELDEPFYRTCQEPAVDAPREKAAFVMLARNKELFKALKTVESIEKHFNQWFHYPIVFLNDEPWSDDFISSMNATVSGGARFEIIPKDKWLFPEWMDTADAKQSIAQQGHAGILYAGMETYHHMCRFYSGNFYTLPALQEYDWYWRIEPDVDFYCSITYDPFVEMAKHNKVYGFTIALPEEPRTCPSLFREMADYKEQNGFRTTELWKAMVVPSWVPWPFRSLMAMFRLRDKNGDAWNKCHYWSNFEIANLAFFRGKEYQGLFEHLDRSGGFYYERWGDAAVHALALGMLVDSERVHHFEDLGYRHDWFYQCPANAPGGQLPDSKLLGDYKWSPEREGGLGCRCECDGAKTRNYATYCLNRLKQPNTTKRIGFFGWLYSWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TYZ8</accession>
    <name>A0AAE0TYZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_542853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TYZ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042239830" evidence="2">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3384833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="152" mass="16257" checksum="65446CE51C02C38F" modified="2024-05-29" version="1">MYFTKTIAATALLLLVQLAGAAPTIETTSLLPREPSSEDTSLAAREPLRGTLIDRAATPGTFTYYNVETGSVGACGSRNRNTDMVVAMASADFKQSNCFRKLRVKYNGKTILVQVTDSCPGCKKGGLDLSQGAFKQLANLNVGLIKGTWEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U049</accession>
    <name>A0AAE0U049_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_473436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U049"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="238" mass="26925" checksum="B692DB8FEAF6AA38" modified="2024-05-29" version="1">MNGEDPQERPDSIRTVINGLERYNPEAAGTLEGYLQLQCEEKFCDCNANRALLKLYQLNPDRIKDEVITNILVKAMTQFPSPQFDLAMHLLSPSHSNPAPTSASELAEAVAKLRALNAQLEGAQYERFWATMESDEDYADLTTDIAGFEEMIRVRIAQLISQSFREVDAGVLEKWLGLDDLESVTKFVTETCGWKVDADGLVHIPKNPENEAKKTEIREDVTVDMFARQIKRSWEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0M0</accession>
    <name>A0AAE0U0M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_508576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="337" mass="34670" checksum="0DCEED9B8F1862A6" modified="2024-05-29" version="1">MVSATTSTTTGACPLPTQDDSADDDFAGCSDGGESFACDDLDCDGLVIPSPLPNAGAMCLGVLSGCACTGATANTPIFCPSNLLPATCEDNGCNGTAVSGSPICQDAFKGCACRATPRTPGNCPNLGRCSFCGGTAPPGETFGHCPVTGCLCIVDPVQSTTITTTPQQPSSTPPPAPPTPTGGFWLGHFTTNFGNNIQGLTFIGDKDNSCARFAQFSVSNIAAFQAFANDASGNPIINAVSTLSSPNTFSVSTELLGNESDLCGIRGLHISFTPDGDLLAFDDHQPGQSDTQGFCVRVQDSGTTCTPNVPDLPFDITFTLQQFWHCAALNNPDYCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0U7</accession>
    <name>A0AAE0U0U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_382847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0U7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="33958" checksum="5FF6A5B663F3F792" modified="2024-05-29" version="1" fragment="single">LDFTKIPIAHNPSGAPPNFQYGPSLQPAILGSGVTLMSIAIVFVTIRLYTGIKKAGKLFADDYLCLVALVFELTQWFVFYPALNQGMGKHTWDIPVSAVSEDVLKRQISTQMINCAAFFPAKGAILVFFLRVFGRLRWVRITCYVLLVLIVIAYGTPEVAWLARCIPHQGQKWDNTVLQRCESVQGIFIMTGVCSVALDLAIFIIPLPIIHSLKLDKQKKRGLAVVFMFGFLVLAASTVGLAYRIILYRGTDDPLWHGVNLYISAYCEVFGTIIVSCAPAISSFWTNIFTQTKLYASFRSTIGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U335</accession>
    <name>A0AAE0U335_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_95732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U335"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="493" mass="54194" checksum="7DEE760608DD887A" modified="2024-05-29" version="1">MDKLFGRKPVVARVPTDRVVPLHFFEDSQLVQGNNMAVPLVFDDVLDPEKLRQSLEGLVKREGWQRLGGRLKKSASGKVEWHIPTEFTSDRPAITFTHVDHGIPAAAHPAASKIPAPSTRPAIVGDPDDLADLAWEAGYKPGGIADYIDSDRPVLGLRVNSFSDKTVVVLQWQHVAFDALGLQYVVENWNAMLWGREETIPTPCGLEADPFDALAKGTRPVLGSHLLADRRVGLGGMLMWGLGYGVDMLVRAKENRMVCIPETYWRVQLERALAELRAEAVEKGKDVSKVFLTEGDILTAWTLRNVVTPMNMDPGRTVAASIAMSLRKAFEGDLIPVSASSPYVGNAFGWANVLVKAGDVSTKPLSWLAREVRRAINEQGTRAQHEAYYAMVREGLGLPIVIFGDGGMAQIGFSNWTKAGLFDLDFAPARKVPRDEPCKPSYVQENHGPIKPADGFFVLGKDHKGNYWTSACKVNGGWAKFEAQLARDFELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3A7</accession>
    <name>A0AAE0U3A7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_98847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3A7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24988" checksum="5C1F8E3B22798BE6" modified="2024-05-29" version="1">MPKSWIAVQRLRTRRNQGLIVTSRSRLYPGPLQITSCHQSGVRTPDAIDKESPQAILNEKDTSTPWFSSSSTRQAVPEMVLPTLVTAACNGKPHTVQQVLDQGADINGRSHYATPLEGAILGGHEPTVRLLLDRGEHVDGPEEDNMSPLGVVAQMGHESTVRWLLDRGMIVRRLDLISPDDREWRSCTPLEAAFEVGDKSTVCLPPGHGTAAGDKHSVLAGTTSLFVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4G7</accession>
    <name>A0AAE0U4G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mono-functional DNA-alkylating methyl methanesulfonate N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_116068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4G7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1194" mass="132624" checksum="4C466861F8DEB01F" modified="2024-05-29" version="1">MVKAEDGNGVRFGLLPPKPVVPLPPQLLLVVLESGDCVFLFVRPGPDARPEFVAERFASPSPRESLEHPGFHLTVDPISRYIVLSYAQDLFVVYELEAMAELRRRHLYNEPLKPVKRHFLRSVQGAIHTIEFLYPQTGDHRHMDVILLLIVVKDKKSKMVTFDWEVGNDLRTVFAQPRAEHRIPVEYQMPLLIIPLTVQSAFVVISDGEVAVCTGFLHGSPIFEAIGMGSRPPTPNFHGRGEPLWTAWARPFRLAGYFKTRDCIYLAREDGVVLYIEADAESTLDRSTYMDQFNCNTSGAFTCLFDQYADVIIMGSDSGPGGIYKVPARKPLERLGKLPNWTPAVDFVTTDKFSSWNPEISGEKGSKTEPWHYPELRSPDRIFSASGLRNEGYITEHRSGLRAIISLDLEYGAGVKEAWLLPSHHTGSSPGFHLLLSMSAYSTVLHLSEDFSQANNLGPEIVNYDLLSPTLALSCSDPFAVQLTKESVVLLAGGKSDRFLYDDLIPDASPFSGLVSDGCVLGNNIAIAAHRGTQFQIHTFKVDVPRLTLEPGCIFQVDGEITCLSLDMHSTVLAGIWKDARPFLSIQSPQMAQGCFMIDLSEHLSNEDSDYNSTPSVPIEPISSIVSIRGAIILGTRSGEVISVRRAADSFSVLSEKFGMTTAIVTCTHHPNKVEPTVLVSCDKKLVKLATSHLSNGQSDAFQLNSKLQVWPVDISNEGGAAPPVEFGVAVDIPSANRDITPILMVSGKKLLLAEMNDKPSPVPRDIPVNGTPTKLLYSPHLQCLVVAVARDEKTTLMFIDPDSGEDLGRAMDKTGIPTDFISGLGKLGDRIWGLVEWECKKEGNIWRFVLASTRDGRLVVVETKKDQEDGSRVIRYTGKFQVRASEPIYSVVGYGEGLIYCAGNTIKWEVLDTVEKKLKLLKVFDLGSPATSLRISNGKLLALTHRDSLEIIDQNLGTDGTTPLSHVDPRRRNATHMIEAAGVQSEETLGSLIFVSDRDCSVGGLWVPWQVPGKDCESVFEAELPVSVRKFRRGRTRPVWEQGPRHRPKYGRLVNTVDDAEILGNALDGSVRSFTLLNLEIWRILRFIQNVAETSDEMYPFTYRVVDHSQFDPEPRVGKEGEMHVDGDMLRRCFEKRALERLISSPSYESRFAELLDELDDGRHTAGLSADEDGEQYFKLAYGILEYFLRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4X6</accession>
    <name>A0AAE0U4X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER-golgi trafficking TRAPP I complex 85 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="819" mass="89961" checksum="31EC90262D80FC80" modified="2024-05-29" version="1">MQPFEDAPLSEPVQPLPMAASASAMRPLPKQRPSLTAGTGIDSHPLAQSEASLPLRDRRSNPSAASLFRSTLTPPGSRSASPAPSSIGTRSPSRTLSGSVFGGGGFKQSLLDTGAGDNPGDPLNLILKSFVPHIAIHGSKDVDDLVSEKGFTGGLWELLRPFGERIQGKVTIRDSNGGSRSWEDFSVRFTRFGDGVEAPDPMAGAMKSPPTTVSAAVNGQPTGAKFPLSMTRASLIAQVETVVDRHLGYAEDACMGVSSPTTPTRQGLDTDATSPYYALYLRRLLSGIPLACHESFAHPVASVMAISSRNPSPIEALRKLYDETSQGDRQLPVWVDGGYLRYYVLVHDEERSDITKSMALFDQMKRHFGLHCHMLRIRSSQSAETDDDSIPLPRSDWLSPAEELADIERSDHQDEEDFEDPTRRHIFESDATAIRTFIREMVTQSVIPTMERNISLWNDQVASRRRGISGRFMSLSKRWAFGSSSRTSGAGGASSDSSNNYGALGYYKPDTAEAIMRRLADFAFMLRDWKLAMSTYDLLRTDFQNDKAWKYHAAANEMAALALLIMPQNMSSKTRIETINQMLEQAYYSYHTRCNSQYGAVRCIVLALELLRLRGGSGVDEAVRWGIRLLETRLMGPVGDALLKERMAICYASKQGAGSQAWGSRRRKSALWSVLGAEAWISQSKFIQAQRCLNEARKMYSLLPGECGVQNFAVASDFLAHLNEQLKEGLRIDTQRGEGDDNYDNNADGLQPVEPELLVDEESETLDNRRKTRRTSMINPSGSNTELETAPLTTMAPARLPSVDSEESDADSSAKDGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7S3</accession>
    <name>A0AAE0U7S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_443822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7S3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23110" checksum="2B51CF85AC3A860C" modified="2024-05-29" version="1">MQKSELDNANPTILNVSELPSRRRTGGTARHGPDSKYDHIVFQKQVWPGISSRAVSSWPSDEEEDDDDDTPIEEPIDEQEIYDLISTISDPEHPHTLGQLSVVRLPDIHVTRPANAWSDPQSLTTVLVELTPTINHCSLATVIGLAVRCRLEQALPPSYRVDVRMKDGSHAQDDQVNKQLKDKERVAAALENDTLRSVLDKMLETCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7W3</accession>
    <name>A0AAE0U7W3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_25413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7W3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="870"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1168" mass="126078" checksum="488EECE71120CA0F" modified="2024-05-29" version="1">MEPQSPPKRITRARAAKAVEPATKTTKIVTAAAKAKATRSTSSTMSTANKRKTRPDDGDDSDHDDLDNVEPPPTSIMKPTRATRGRPKKTVEQPPPQQDSEQPPPPVKAARGRPKKVIEPPADEPAKPVRATRTRKITTEEAEMPAEPIKKTTRGRLPLTVAPKTAAKPALKKSVKFEEPEKENIAPAAGRKVTAKAPEPAPATTGLRGKPIRRPGTAGRATAARSTRSAPTVSDIKEDKPIPLSPKKINQLSMSRADSDDELAMDEKAPVRRLKKGPIKPPALGITKSAIDRPAAVTATGAEAADGNLVLAPPEPFISLGSPARRLPPSPFKNIIKSPPRRVEGVLGAPASQARTDDQTAQSPMKMSLLQSPAKRPPVVMGSAGGAQPTPLKMSFLSSPAKRIASPAKAAIPNLAPKATLLTTPLPTQYQYNAHDDDDMMDENGDDAIPDSPTRLRFPGRLSAVLPRHADPALASNMMSLPEDAEDEEDEDVQVTEVENVENAALSDAMAVADVHSEEEDQPVHSADISPPCSPPAAAITGRAMFGLREKDLDGYDHDATESETDEEEPASDFHVLPATPCPAVSSSKKANIRTPSVGRSTVKRVRMDDKFGFTPLADQLSGWTAGPSPLKTGAGQETLVPTSRAVPAVSEPSPMRNTFFEDAMSAAGPAEADLANEEEEKEMAADLDSPVLEDIPFSEEDVALVAEANEMSLMEPEEVEEMIYHEHQNSMDDSISEASQEYGDENENPIDPNLGPITPQRAAMAHREFHTVSKIPLKPADESSSQKIKKRSHSISRLPVQRPPMPRSASVISYSPMKQSSKSSSEEEDQENGEEERATSAPPPVTPSKSEAGSWSTMGTPARTPRRDLNPALLRGAVVFVDVHTTEGADASGIFVELLSQMGARCVKSWSWNPSSPPGKDGSAASKIGITHVVYKDGGKRTLEKVRESAGVVQCVGVSWVLDCERENQWLDEAPYYIDTSMMPRGGARRRKSMEPRAIANMNGMLVPTPVRNTNNGSHKQSSPRTPANGRRASALWVRTPENDEDADHEDDEEDAEEDRHNPEWTSMLTPVPKTPAPEAIARFAANLDLATPSAASEDDDDDCEDPLVRRNVLMTRTCPPKKPIMLGEGILGKEKDERVLMRLMAARRKSLQFAPKIGSPLARAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U894</accession>
    <name>A0AAE0U894_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_461532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U894"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="95" mass="10270" checksum="586D8EF86EFD23AA" modified="2024-05-29" version="1">MACAAVLYVLTVPSLPRSNSCPCLPPTNLGVDHPQERAWTGVRDSAKMVSVSSTFPSRYPPSLDGLTSSVNSRMASNAPRVCRSWGFRDESTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8S0</accession>
    <name>A0AAE0U8S0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_408547</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8S0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042003611" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3395198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="274" mass="29756" checksum="06292138DFED5C60" modified="2024-05-29" version="1">MRASLVALVGAVLIPDVLSHNIQGILLVNGTDTPEWKYVLDVEGPWAVGPWDYPPGSQAYKLAPIIGASDPNITCGRAAFNAAPRTEIADVLAGSEVGFRVSADGYGNINEPYPMGPTPPSFWHPGPAQIYLSRAPSDDLHNYRGDGDWFKISYAGPLDDSHWSLWGSAAHEFNFTIPKTTPPGKYLMRIENFMPTNAQRDYTQFYVNCAFVNIMGPGGGGTPPTGFARFPGTYQPDDPGLVVPLNQDLMSGRLGVEDMRLMQYKPPGPAIWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXC8</accession>
    <name>A0AAE0JXC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_498231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="JAULSW010000017">
        <property type="protein sequence ID" value="KAK3365461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXC8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="733"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="824"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3365461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115184" checksum="7161D4B379BFEDFE" modified="2024-05-29" version="1">MTRPITSDVPGTAAPEPPGCSVRPPPSATSNSSVSLNSQHASPALSPVTAGTSMTLGSSAQDSPDLLLEPFPSTRELDEMDAPAMSEAVKSASLIRRGSNSLKKSHERSPRPRRHSSTNTRSRDGSVAGLMRRRESASNNPNPLIEHASLHYSESDDDCAIEREDDGSHAESTSSSTLTAGPVVPLALRQGTPLNKVTKKKGLKKITLVLDPDSAKIWWDRNRPSKSIYIDDIKEIRTAEDIRQYRLDTGLGEEYESRFFSIHYTPPGESRAKVLHLVADTEDGFRTWTEALDAISKHRQDFATSLMAFNDKAIRTYWRLEMAKQYGDKPHLPEEEHIDFLGVERLRAKLEWVKGRKSSLDDQPPTQMCSSRLSFDEFLEFVRLMKARKDVRAVYSENAADIEGGMTKSEFLNFLRHVQRENVDEDLAAWENVFFRFARKGKPREAEKAANGSAEEGLTMSEAALASFLTSTSNVVIAKEPKGYKLNRPMCEYYISSSHNTYLLGRQVAGVSSVEGYISALMRGCRCVEVDCWDGPDDMPVVMHGHTWTTRISFLEVIKTINKYAFVKSRFPLWISLEVRCGPATQKNMAKIMIEVFGDKLVRTPLDPSSDVLPSPSDLMERILIKVKQAQSQEEPPKNGEWFGRRRGNSQPSPYQRALESLPSATPMPASPLLSATPLTRSSRFINTITEGEVHDAPSSSPSECESECEKDSAVAKRTMSKIHPDLGDLGRTFAEKCQTSESKQTLYRHNMRHLMRVLSQWQPLYVLQLRSTDLLEARCPDGGSQLADVRPGMQLNQAMFDSGTDQSGYVLKPIEGREIQMVPPGQELPRGKRPRKQVSFHIDVISAQQLMRPWNLGEKRTMDPYVEVEVLLADDKRNKQDVPTDPAPQLKYRTSIVRENGFNPVFNGECKFDVTTKYEDLIFVRWSVKLAEKSKLGEKSFSEKTAPFATFTAKLSSLKQGYRTIPLLDQNGDRYLFSTLFCRIIKGPVTMKMVDYQEDTPKNGSILKNFSFGRNGSPKSSVELNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0F7</accession>
    <name>A0AAE0K0F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="15584" checksum="3B559911604B8790" modified="2024-05-29" version="1">MVRRIKEQRGPRPTIGGPRYLKDLEPQARRAEENEQLLSQQQFHDRHGVSDAAKIARAQAWAEWTNFSKHILKIDPDETILDLCRAPHKQAAAKLQYRKFLKHYIESSERQRPTLGLEGVVWVLTVTSATTVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0N9</accession>
    <name>A0AAE0K0N9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_515593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0N9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3367839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="43926" checksum="75B380D6172E5980" modified="2024-05-29" version="1">MSPPAPETTTADRFLPVSPAGARNLEPPAGCQPGGYHPIHLGDFLGPNGQYEILCKPGHGSNWTAWLALDRSSGSIVHRHQQRRALIRALPPNDNRVVGLRSVFSLDGPNGWHVVMVLEAMGPDLVDVLNPICTLVTSWRISARWGAHTWRSSFDSREASAECRVPLIRRDGQPADYWAPRCLVEPAPLVEWLDSFGALDPMVKLTDLGGRFFVPQQGGGYRGRVAVNVALRAPEVILNSQPGQYHSSIPLGKEIDIWTFGCLTFELLMGGLLFKELSELAPDPEMNEETNNEHLIQLVEVLEKQYFDEQGRRRDLDGDSDDNSDDTLGSGSDSVLAEPDQFNMLEKQLDDGKPADMNEDEMQLVLTMLRRVFRLEPSRRPSAQHLLTHPWFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0S4</accession>
    <name>A0AAE0K0S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_515624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="129" mass="14538" checksum="EEED90867C136A40" modified="2024-05-29" version="1">MTFLLNRLFTMGNSLKLIRQCTKYAQNKSSKKAEEQNLAKGAITAIHQTATWRTEGVWNPAAADSSDVPIGNISNFPYLKKRLDVFGMWHFPKQNNTGKSSRIMRAAIAVEKVVPVTRVYAPKIIWQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K131</accession>
    <name>A0AAE0K131_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_67926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K131"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="817" mass="85594" checksum="533B82BD4B6ED4C4" modified="2024-05-29" version="1">MPVQPAAIVQGAGSTMSPMIRSQSTPLPVRAQAPAQTPAPATPPRPVSRTTPKKATGQKYRQTTLSLSPSELSLSADPSAEIAPSKRNAGQGSRQTPNKATEQGLRQTTISRLPSELSLSLEPPVETPALRQRQTPKKATQEDLQQRMVPSFLDSASNSGGQATPRQTPRPSSMPDPRPVSTSGLNSGNMTPRPQLAPQPAPCMPSSQGNVQLGSPVNSIMGFHGGVEAALQSQVGPSDAPRSFSVPRSGPSPLGAMAPPPKPSIQEASPSLSTCGAPVGIRKSTPQASTRQARHPALVASSSPCIGLPPGYTSKIRGLASSSALPELLAQAQQKRAASGSSWSPGVSGGNNHHVLHSQIPFLGFNPSLGQMGSPAPPVVDSAPVLAEPKPTNTPRPMTQVTGGQDLANTTPQPGQEAVPNELQNLLRYRASSSQKLLAQQAMLNMSRPEFMQYPNSDAMQPQRQGPLSQMSQIAAAMGHPLRHALANFGDLVSTQTRSASANGAGSVPTQTGSASANGVGLVSAQPLPQHQQNRNTSANVAGLVSAHAPYSYPNSRTVANGAGLTPTQSPRSHASSILQGSVLSQSSRQRPFQQNSANVVNLVSAEAPRHRPIQQNSTDVVDLVSADSPRRQNSVNAVGSIPMQSPCRRPVEHISANVAGLVPRQQNHQTLSNVAGLVSMQSPRHPLAVNATGLATLSPPSHSTSVSPQPFSQHQTNYQTSSNFAGLVSMRPPCQPTLLLTQPCTQHQTNYQTSSNVSSSVSSQPPSHLALVSPRPLPPQQPNDQTSTNVAGYVPSQLFPQSPAPTSQMTVEMQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1K4</accession>
    <name>A0AAE0K1K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_488360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1K4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="37161" checksum="136401B69905A0DF" modified="2024-05-29" version="1">MATQTGITIAGPNEPYTVVDNIPRPTCGPTQALVKSLFVGLNPVEPFMQHTGVLIAEFPAVIGSDVSGVVLEVGSECKKLEKGEYVFGCVPVGLNKFSPFQETFLAEEDWTFKKGERVGLEEACTVGAGVLTAGLALIDGQGLKVPAPGTNAEQKDSWVIVMGGSGSVGQYACQIAKLCGYKVLASCSPSKDEIARKAGATATFNNRAPIDEQLGLIERITGGQFGRIFDASVQAVQLSIKALEAISKESDKYFASADDWSEMDVPDSISVYRVQLGLLGRADNPLSKRVTDQVAEMVRIFEGQIEAGGLRPLDYELAPGMGWDKVIEGIANLEAGKAIKKSVVKVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K269</accession>
    <name>A0AAE0K269_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_403924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K269"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55141" checksum="01FCD986BA6A5F4D" modified="2024-05-29" version="1">MNPPGLDGHGVPRRNPKFSGSTPSLPSVSDIAVSDTGVEGLGARSPNEGSDIRNTIGPKHNIRSQDGKWVRKHNWDNPLGLEDDYVFNTMPFNDAFVTAWDNGVPHDISADFLDRDVREHWRCDVDTNTGYLIPPVEYPETLVDLGKLREELDWRRQNWTSALLIRRNTANTRGNLRGRRYENFQLRHYQEPNEPEIFEINPVVEEPKIEIVHNSLAPRVASYLRPAQKADMAAVTAIYNWEMKNGLQTLDSQPLSVEDFEKIFDDTQKLGMPFLVAVTGSAKDLKSKHNGAVTLSLYRHMPVDMVTLPSQDRNGKILGFAYLSVWQPGLAGSGVGSSRATASINLFVDPQFRKMKIGFSLMDKLLSTISRRFSSESAYDFVDPTRSPVYQGPKSHERQYFRLYLSYLVKHKYADHQLEEEQKTYDDDLKWVKKLLEEKFNFREKIRFEAVHRSAKAREGPLCWLDSVVFEHACQFGPADCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2G7</accession>
    <name>A0AAE0K2G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 71A20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_514990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2G7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="498" mass="55927" checksum="A7EA2C21C5C75E52" modified="2024-05-29" version="1">MHCLSSTVGLVGLALVGFCLVVQRIRGYRRLRHIPGPFWAGWTDFWIIRTQLSGRMCFILADVNEKYGPIAKIAPNWVVCGDGAELRRIWGVRSGWERSPWYKGFRFDRNLDNAFSTLDDKVHETLRQKLMPGYGGKDVDNLHQQIDTQVAGLISLLETKYLSTKTDFKPVDLARKVQYFTLDVISSLAFGKELGYLAADKDLHDYIKTTESTLPIMLTTTLIPWLLDIVQSPRLSWLIPDVRNMAGIGSVLGIAHAAVAERFADKAVVKRDMLGSFVANGLTRTEAEAETVVQIIAGSDTSATAIRSTLLFIMTSPLVYRRLQAEIDAGIKDGRISSPITDAEARNLPYLQAVIREGLRLWPPATAPLPKISYQDQVVCGVHIPAGTHVAWAPFSFLRNKDTFGPDADLFRPERWLDIDPAKFRAMNQTVMMEFASGSRWECLGKTVAEIELNKTYVELLRRFDFTLVDPTNPWDSYNAAIFIQSNMNVVVTRRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2J8</accession>
    <name>A0AAE0K2J8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2J8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042062037" evidence="1">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="321" mass="33572" checksum="DF4A8CDA1E8CA212" modified="2024-05-29" version="1">MRNSVAALVFATAANAARVCGTTGTAPTFQYRLLEVRYDGPDPDKANGLSTIAVSLGTSTTPLYECVAQWPEAWAGWYEGGGNIIWADCIGTGAGTGADKTVSFAVDWKTKNLHLSHTFACSDKKGSDGLATGSLNLDLNCTTADGYNFCIPKGASAGNTRPALSIRTTLGLAPAADPATVTCADASKRYQSWRLENWLRQYELVPGSSDIKASSDTGPSFTLTSLANAAVVSCATSGRGQNSTFVGSCKPTGSGSSTTATSFSFDPKLFMLTISQHWDCGTAATSLDVVGIEYMQATCSRNYNSIVFTCTSSPIWVGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K495</accession>
    <name>A0AAE0K495_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K495"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="157" mass="17946" checksum="833CF44A54CEDBBE" modified="2024-05-29" version="1">MKYRSCRTGAEHRNGMESKFVYINSTPRRSHLSFIRRNNNSQPRLTVFFFKFVFLTSTCGTLKKRNSLLLLVCSSFILKLHYPTQTPNSTTPIRNPSICISSPPSLPPRSLLASHLPLHRPQHLLHPMAPFPRAASARSRPIRRVTQPDTANARPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K522</accession>
    <name>A0AAE0K522_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K522"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="694" mass="74581" checksum="058B7E4BC447589C" modified="2024-05-29" version="1">MSAMRVHTPDEILVELSPSPQGSSFLIQAAPTPPPGTALSPPLSQNPFVPALPPRKPVPLASPPAADRPGEAVQVQYRPSTSHRKPVPVTAPPAQVPSRPPTPQRKTAPTPPPPTPPPTTALPLPPNQDPSHPVPLQRKPVPAAPIRQKTPEPLANPVPAFPFSNLPSGNNSTASNWAEYRASSKPALRNVSLVPDATNPRHTATVLAPPVPALPRLNPFRSPPQRKDTQGAPRVLSPPRRKPVENQASVNQPNPSSNSSPTAPTTAPTWGQDPTYPKPPPPVAPGLSFAEPLSSNVEPRASPPRPTSSWYQPNFIPPPPPESTLPNTVYRQSVYRQSIYRQSTVTPKGSPSKPAPPVPPIPQSSPPRGSPPKTSPPVPPIPQSSPPRGSPPRASTARSSPPTRDSPPRRSPPRPSPPVPRAAHVLSESEESTSSQDSVSSTRPLIVHLRQDSVLSNPSRQDTLLNPSRQSTGLSQSTSPSRPSQSRQSSFFSEKRGPRPGNLNTSRTLYMDMLLALDKIPRLHNILVSFFTWIMLVGFVVMTGSFTSGEIAPPDDGTLGTPVNASMLVVGVVFMGMGMIGVGWLGYRWRKNYVWLLNKLYMPLLLNALAGVVATIVSIYAQHGGQWRLQAILTISVEVFVLIVSSLLFAVYNFWFLVRVKGDHHVAIGRDRKSLAQKVNSARKAPPLAPGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5W5</accession>
    <name>A0AAE0K5W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="92" mass="10253" checksum="A87FFA6218B9ED20" modified="2024-05-29" version="1">MGRRALTRKLCEFRRRVKFSCLAAGLDSIIAHCRPIVRMIFFVSPGANLTNKTHTIIVTICYPGLTVCLVGSSAFRQVRYTLASGGVLFIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6U5</accession>
    <name>A0AAE0K6U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64922" checksum="E705F67C86920E6B" modified="2024-05-29" version="1">MANPTSKKKRVLVVGAGAAGMSCAHHLAEHPDKFDATVIEAADYCGGQAFSISIDKSKHGASWLNQGVQGGSYIFHHTMAMFARQGYAANPVKLQVSFGKDDQFWTNVYPTKLLERHQGEIRRFAWMLSIVRWFELVFALLPIKYLMKLFWFSHEFANTVALPMVALFLGTGNYTPDVPSIILERVCTSPTYGMWYPPDKESIASNQPPMVVFPNFSRFYQDWHQDLLKRGVKVRLSTELTQIIRRDKTGVTVKTIKRRSVKDGHNLSSAWAREDGTSNADAGAEETTEHYDEIVLCCLADTSLRLLGLTATFRERRVLGAAKFSDDLTITHHDSSYIRQHYEPFFNASQAAPILAGHSHADRVERARTTFRPMYFIKPYPQDLTKLEMCFDCTNYQGQFPPDVPFDGGHVFQTIFLNKQRDGNLWTDGEIDESKVIRRDWWHQLCHSWTHYAFVVPWLWLLQGAGRKHTRFASSWTMVNAHEVAIMSGLAAAVDLGARYPEDLERDKFALLSFRLYYLLVYGKWYRRKAATNVGSGDDWASGLYGSVYKGPGVVETERKMWMDERDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8S9</accession>
    <name>A0AAE0K8S9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_401532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8S9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="555" mass="66036" checksum="D2A83E63A31DB9E2" modified="2024-05-29" version="1">MANRSRVEFEEREYYREAPQPRRAAPVREYDDVDIRISDREDRVPAFMREQDRRAEPGQLVLRSREVETVERPRRPRSPSPQLRVRETRIERARSVSPAPPPRRMEEDIRIRTIDRERVREPSRAPSERIRTRIVERERSPSPSPPPMERVRTRIVERGRSPSPVRERIRIVDRREERVPSPSPPPPKIKGPVIEREVITHYRDIDHGKSGMCIVAAPRPPPPAPIRKERERDTEIDIYTSRHHTDIDIHKHSHSHSRGRSQSRERPSRRPQQSWDDEVLVHSHRDHLHVDIDQHRSSSRRAQSAAPPRVEYDDEAYEITQRIDSRGKMGEAKGGITRDWTIVDVPPGTERVRMDGAGGASAEVTWQKYSGVRRAKFIPDRDEQSTTVSTSTTVSDRDVRNHSHSHDRRLSVQIFDKEKEREVDIEKVTDRRLSIRTPAPPAPSPRRSEMWTEITKDLVCREAIDQMGYEFEETEFFFYIIEYLRYEDVLQLVQLSDTIRKARKDRAYEIQWEREYRDDVHYHRHEHKHRHDHYDDERIVEREVVYENRPSKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAG9</accession>
    <name>A0AAE0KAG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAG9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="39737" checksum="DE7784239BAF4F53" modified="2024-05-29" version="1">MPGLTVTTDIPAANVAAPAPPAPAQPGTSSNTHHTSPQRTSSPTRPPVSPITPTLGPKRISSSGTSSKTTGAKGAKGPSNSDNSIPDDPPNFALGRPAFAHSQPDQVAIAPPAAEPIAFDDNPDVLALKSAISILQLQRARATADMQALSRAKAAALADPGAFVADLAAGKVGMDGDPLMLPGGGGDSDGSDDDSEEDYDSSPSSPSSSDGEESIKPEPESESGSDSQNRITTAQTDTDGDVSMTGDSGGGPDIPTTTKSTKSNIRKKRKGSTTTNPDSSSSSDNKQKARGATENPAAAWRKLPKPQTVVRCPPVNWAQYGIVGESLDKLHAEQVAAPTLGAPAVLGPGATYQFKGGDAAAAGARGGRLVGIAAPYTPGRDKIDKKAKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAS7</accession>
    <name>A0AAE0KAS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_551323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAS7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30438" checksum="53EC608477C5786E" modified="2024-05-29" version="1">MMLRKIKNRLSRAAQRNKVPRATDNYARPEEVYDYDALSTRCQSSVSASSRSSSDVSSSFSDPSDYFMQWDAAMATDRRIPRDSTSSSGFGSLFSASASNNSGTPSSASGHWPQEVFHDWAGFIESLPFDDEPTPPAVPTTAALPNAQSMPLRTAIASVPTAVPPQAAQNIPPPQVLTLPRAESPVWEKPLMAQGSANEEKDCVICADSKPLNEFPLLCVSKNCNHSPDACLDCIQRQLRMAMEDKIWCADVVTCSQCNASLEYNEVQLYADRATFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDN6</accession>
    <name>A0AAE0KDN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDN6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042128121" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14558" checksum="8436A9D5C0A8A9DE" modified="2024-05-29" version="1">MRKLYRIVSMMFMLAPIAVVGGLSSFAAGSRSSDNDRGWMMLWLVVGQCHQHGCTLSGHYSVRPLRPGSVLSSLPLPMLCIILSPFRSGFLLLGIWSRWRECWETTVFVRGLILQNIHLKSAVQSMSYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEG1</accession>
    <name>A0AAE0KEG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_496116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEG1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="17133" checksum="2C4CFF3B1DBE6CED" modified="2024-05-29" version="1">MSSSGSQSCDRPALGEICWVEVPVTNVGRAVSFYRAVLGWQTEDAKPTPDATADEKPPSPVPGIDIVHFFSKGRLNGAFVKVSDESSLALVADEENPHKMPPLAYYLVESVDETLKKVELAGGRVHVPKTAISGGTMGFFARFVDSEGNLQAVWSQPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KER9</accession>
    <name>A0AAE0KER9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_496218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KER9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="31551" checksum="229FDB22120C8AE8" modified="2024-05-29" version="1">MPHSGEQGQAPHPYDAHHHRASLQHAGPSPLHEPSAHQSHHGLQQHYNTGHHPHPILTDPGHMGGHPGARHMGHSGPPHFGAAGPSPHAVVAPLYPSLTPTHRPSGGVKRQRPDDLDLSVSGIPDLEQSDLESMQQQTPMGTAYAQAAGAPPTHHHHRLPDTGPPNKLMRREGESSGGGGAPSVVGQAGMPPPAPRPRGPKLKFTPEDDQLLIDLKENKSLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTQWTDETHFKIMRMRNGALLPTRLERALRQPHVARERTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEY0</accession>
    <name>A0AAE0KEY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_437900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEY0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="679"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="129"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="918"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3374932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="954" mass="104912" checksum="9F13659E9BD1D36B" modified="2024-05-29" version="1">MAPPKGGGGGKKQATLGKFFGHPNGAKPAPSQQTKLSFATKPKDKKPTETAPVVVAKEEEEEEEVKAMPAKEDQNDDDVPTKTKKEADEDDEVKDIPAKEKKDGASISEGAKRGKKAIMDALGRMGVPQPEKVLVTDTKKRTRTAVPESKPPAKTLAANGKKDSVAVDDVEDVAPASKRPRRDRRQVIEDDEDDEIMDDAPPPAKAEVTEAVKPKSAATPKKKDTKPPKKAEKVEVEEATPETASEAEEDEDAEEEDIDDDEKPIVSAKARKTIQTVLTSKAKDPYPDWKPGEPVPYAALCKTFSLVELTTKRLIIMEHCSLFLRQVLRLTPDDLLPTVLLMINKLAPDYAGIELGIGESLIMKAIGETTGRSLAVIKQDQKEIGDLGLVAVKSRSTQPTMFKPKALTIQGVLKGLMGIATVSGNGAQGRKVDGIKKLLSAADANSTTGKVDITKDKGGPSEAKYLVRFLEGKLRLGLAERTVLVSLAQAMVAHEATQKGQVPSTADLEKGESILKTVYSELPSYDVIIPAMVKYGIMNLREHCKLRPGVPLKPMLAKPTKAITEVLDRFDGQTFTCEYKYDGERAQIHYVAKDAGEELSQSLPSATTEAGRGVASIFSRNSEDLSKKYPDILAKLHTWVKEDTKSFVLDCESVAWDVDEKKVLPFQQLMTRKKKDVKIDDVKVKVCVFAFDLLYLNGESIVEKSLRERRDLLVKSFQPVEGEFSFATSMNGQELEEIQVFLDESVKASCEGLMVKMLDGTESGYEPSKRSRNWLKIKKDYLSGIGDSLDLVVLGAYYGKGKRTSVYGAFLLACYNPISDTYETVCNIGTGFSEAVLEELHAALSETVIDRPKPFYAHSAGGQHQPDVWFEPRFVWEVKTADLTLSPRYKAGMKEGVDPSGEKGISLRFPRFIKIRDDKKPDEATSSRQVAEMYRKQESVTKSKGPAVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEY9</accession>
    <name>A0AAE0KEY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_526058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="154" mass="15968" checksum="DD0165D400219AA7" modified="2024-05-29" version="1">MDSNAPGCNVPLNASSPKVDIAIVTLPATVPDTDPSFGGTILVNPGGPGAPGTQLILGSGNTSKACSKVKKATKFSGSTLAASGGWQKNLLDVETILDHFYQACFDGVDGCPLRQTQDTTPTDIRTRVDAFITSLETNLIATVSSSPGHPRFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF81</accession>
    <name>A0AAE0KF81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_452907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000043">
        <property type="entry name" value="Helix-loop-helix DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3375092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="301" mass="32909" checksum="35CAD473EDB7BB6C" modified="2024-05-29" version="1">MATVGMEHPGLSELSNTPGQKRKRPSDSVSPESRRNKRGVPAAAMTVPDAETQAFLENTVSIAQAAQDHVNIEDFNTLVQATADDHNDTASAANASSTAAAALSNMFPQLHVPQSTEETFAAQVAAEQPHHDDMSFNTSAVNQPDGLPMASSGSLQPTNGVSQEQRYSSGSNPKPAVGSEEWHKMRKDNHKEVERRRRETINEGINELAKIVPGCEKNKGSILQRAVAFITQLKENETQNIEKWTLEKLLTEQAIAELSQSNDKLKQECDRLYSELEVYKGLVQAAKIPLPQQKEEPGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFA0</accession>
    <name>A0AAE0KFA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_279644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042250072" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13903" checksum="FB7B11AF496FA052" modified="2024-05-29" version="1">MQLVKLCCLGCWGWRALWSAPLPLPSGVGERARKGLKKGDQLRRTKFFVAAHMRLQESGSSYAAVETNCGRRGEVSDCAAVEKKSSVMAISSVHFTSGIPFLLGRGNANTPPPFVSRSLPRASFMYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFC3</accession>
    <name>A0AAE0KFC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LMBR1-like membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_481951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFC3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3375142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="725" mass="80229" checksum="6E98A40E1F1D6187" modified="2024-05-29" version="1">MIESTTSPSPVPSEIFAGFLLLIISIAVLLILRYYLPLRTTPAFLLVPVFFALWLPASMVLLVPIDLASTAAADNIDNRGIWLEPRALLVSWRITYWLTFCLTWFILPILAEYSDSGYRDPKEKVLDSLRANAQYYAFVFGAGVLGLIYVLISYGNFSTSLKSTVMALAYCWGLILAIYLMGHGLVAIPRRLFRSANISGSLRKIQSQAPRVYEKMEDAEMNLEDLEIQVAELSRRKGGSVNLFQDWIEELVDMMNLPESAQPSRASVLRGSGDASSRILPTVITETYMADLTRRLVRAKHARSRYVNEWNRLLLDAVKTQAILDSAASKKLDFGAASPHAGFWERHTVLTPYTRFLFHYHFVPYARLGLAAVLTLASVCIVWSEIVKGVLPSFSIIRYSVVHHWEGENGQVGFAGQVIAALWMLYMCAAALTSITEVKVWRGRALVRRNTAHESAFWYASQVARLSVPLSYNFMTFLGGIYRDTVFYKFLGQLINLTPLGTWFDYLFPAFILLPVGATLFGLYGKVRRVFGFGVDVIDDDGDDSENNTYGTGSWREGRDLIERELNGTSTTIRGRRAEAAARIAGSGAGPAGSRAAPVLSVPRTSRGAPTSPLGTSPNSRPSAMNTSARRGASASSSRGGGVGTEPEDENFFEALGHRFKNTMDTFDTPKWLQDIKKPKWMGGDDDFSGASGSHQHRRSGGAGNGNHNSDVRRWFGGNDGRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKG6</accession>
    <name>A0AAE0KKG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_229184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKG6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50561" checksum="5356FDDDB0D69A78" modified="2024-05-29" version="1">MAVFVDLEDEDVEPPQDVHQPHPLIWNPAGIEGVKAVVISATAEAARGDDNGSTSNSIVATAGHRLLVHPLEHREEAHGLGVRENPNRNSLTQALGCYPIIASVAANIDLNTLDNLSRTCRQIREGLLQYRKVLLASTLHCSNDHLPVDPEETLRYRAAASNWFYMEDAGRSRGTAKAGQCARDLVKECRRCGTVVCRNCAIKPPAPIVLRDRHRRLCVSCARAPLGLLVKPRLGPEFSLASSDELDRAICKCATDGVWLCQPCGKTIRNNDDVYKSVWRWRGQYADSLSGLGVGIGDGDRGVECGRETECCAGREREQETDCDAADAREAEISSSSSTSSSLFGPWSSTSSNGSSDYIGFESNGINSGSTATATTGNGGGIGRRTPSPTLLQGPGYERHEIEGIGGVVKRKLVRMVKIGACVPEWDDERAAGDIMGREVRGQVRSWCGWCWRVIPAKKDYEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKK6</accession>
    <name>A0AAE0KKK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_231853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="363" mass="40313" checksum="B7E1B5B287AFFF06" modified="2024-05-29" version="1">MVGHMDSLKLQLEEVSVVLGTKIVNATRFEQGLSHDVYMISTEAADTYILRIPKDKTAASIAKTGTVLLTALKRGQPTLQIPSVIYESDQFSILQLLDGEPLKSWNNLDMSVHRRETLLEGIGKLLLDVWTAAAVADASPPDLCTYRAWLVNEVDKGFRRSLARSDWGDPVHFLHRRTIIPQMLPEYDGTMIALKHGDLNVWNVLADGKGLTGVIDWDTAHTVPLAAAVQHPLFIADIPGWLNDGVPPDMTFEDDRVMLESIVHRLSTTSPSPIGKEVPALLRTSGERQFFEMSLRNKQINAEYTREKLVPSSIDKTMALQNLAEFLESNPDLQKDPGIQQLETRLLCLPDPPTIGRAPRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKR3</accession>
    <name>A0AAE0KKR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_242764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKR3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="126" mass="13709" checksum="3D4E6517A85E05E2" modified="2024-05-29" version="1">MAHHLTPTPHAAPAPRRRGGFFNRRKVHHIGPATTTTTTTTTRRRGGLFSGRRRAANHHTHGGGITQPTVVHHQKHHATIGDKISGALLKLKGTLTGRPGQKAAGTRRMNGTDGRGTARPARRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL79</accession>
    <name>A0AAE0KL79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_480176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042219588" description="Glutaminase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="116"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="530"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="664"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="84700" checksum="6DA848D8E480BC7B" modified="2024-05-29" version="1">MRFHLLALAALASASTLTPSVLPLIVRNPYLSTWLGNARNAPWEEWPMFWTGAHVGFSVMASVPSAGTVYPLLGRPQDSLDQSGRLYKISYPYYVGATFDASTTNLTYLIPGSLADESVRVTLSFLSPITPSSTLRQSIPAAYLTIIAEGCFDVNVYSDVNGEWVSGNRENHIKWELYEPAPSQKGQGNTSETAIKTWKVLRSTEQILTEFADRAEWGTLHFSAPADAHHQCGTSTTLRQHFAEKGYLKNEVDGGFRRIMEDEPVFAFAKSFKLGGKAKGECSKKEGSIGLTFALVQDPVVKFAAARGLTLMKPLWQSYFASDDELIAYHYNDFKTATYLATNYSDTLARDAYESGSQDYQDIAALSARQVLGATQFSGTPDDPILFLKEISSNGNFQTVDVIFPAFPFFLYTNPRWLAYLLEPLLEHQLSGQYPNNYSMHDLGAHFPNATGHSDGNDEYMPVEECGNMLIMGLALANSLRYDTEPAFTLASPDHRAEPIGGAKNWLQSVDQYGIDARRDLGAATGPKAAEKWLTNSYELWEKWTGYLVRESLIPHNQLCTDDFAGWLANQTNLALKGIIGIKAMAEIADIVGKDEDAKRYRSISATYIEKWQEYGISRDQTHAKLAYTWYGSWTTLYNLYADSLLCFHIPNKAAAPTREKGTGWFWQKPLGGDTLNESPFIPDKVYQMQSDWYHAVLQQYGLPLDSRHLYTKSDWEFFAAAVTSKKTRTEILGSIAKWVNETATGMFPLSFADTEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLQ4</accession>
    <name>A0AAE0KLQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_496008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLQ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="245" mass="27730" checksum="EDFF0D4FF8A477DC" modified="2024-05-29" version="1">MSRSAAPTGAKQRLMSEMKALRKEKWINFEDDDSANLLKWRFALMVINSDSAFNGGYFRAEMVFSDDYPYQPPQFRFLIPIVHPNIYPDGHLCISILHKPGEDLMSGEQASERWSPLQGAESVLRSVLLLLDDPEISSPANVDAGVMYRDRRTEYEEKARATVQRSKKEIPVGFEMPKSFEPAPPPKAENDDDFWAASDEELDLGGSDTGSDDDDQDMGDFEDGDEEEEEQDGSDEEDEEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5P1</accession>
    <name>A0AAE0N5P1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_552315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5P1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32255" checksum="6E025D26EEF3608A" modified="2024-05-29" version="1">MCNRANPQCTKRCGGCKVAVYCNPAHKRCAREKTEQEETALRASSPDKNVFETSVGMFWAVLEMRPYLSARFHLMMACLDIRTGEAVEAALEHAMDMLWLCGGDNQGVRGYVPGMLLRLGRDQDACDFTKWRATVAWLTEKKHVLDDMSLPTSIELLVPLALMKLRMMRDVWMLQATTEERIAKGKAVPDAWKMRWLKYHALRSVLEERTDTVYQTDYAGTVETLTNQFRTLAILNPHPYANGQLSVYMQGSKEEVVLVMRQSWYSWAETENAVDVVRSWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5X2</accession>
    <name>A0AAE0N5X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="215" mass="23977" checksum="E53A947379D3D9DE" modified="2024-05-29" version="1">MEYLLAAHLEWIIQDPATAIVPAIWTGADFLDESFRAQHIQPRERGEHVKFPFVDMNDFLAKGSPQRTETSANKVCEVVDPRPKRATFIVGSPSPSSSPSPSGSSLSESSSSKDSEEVKALKEEVGQEEEGADTWMLGHYLRSFYVDASENDGIVYAMNMGLGRNPLTAQTNTTFLADDLNQYYRFVNWVELLDAVRDIQGQDGDLGTQFTYAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6P0</accession>
    <name>A0AAE0N6P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_550585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6P0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="148" mass="15974" checksum="36D6BFF532822169" modified="2024-05-29" version="1">MDEQAERDLLLALYTSTQTAIDKDIQANVRAPQDQPHARGGAVRVRLGTSTRACGRPRPPGAESLVPAINIGYDVIAIAQTAARRPAPELPISNKLMDRRGGHDLATQNPASYRLGIGPLVRAEAPVVVVCPSRELAVQIFNEARKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N937</accession>
    <name>A0AAE0N937_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_400045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N937"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="401" mass="45564" checksum="0E490BEE373A3DC2" modified="2024-05-29" version="1">MATTTTQTTTRNRAAGAEAKLALEPTSASPVYPDIQTIRDAIPAHCFQPSTVRSLLYVVRDVSMAVAFGWAALTFIPQIEQTALRAMAWIVYGYVQGLILTGLWILAHECGHGAFSTNQRLNDVVGWFGHSALMVPYFSWKFSHHRHHRFTGHMEKDMAFVPQVKGDHKPRLANLYMDSELFEDTPIVQLVKLIAHQLAGWQMYLLFNVSAGPKSKQRDEAGWLRVSHFEPTSAVFRSNESLFIFISDVGLAITSYCLYLASNVVGWQTVFLMYGVPYFWVHHWLVAITYLHHNHPDVHHFDAEGWTFVKGALATVDRDFGFVGRHLFHGIIDTHVVHHLFPRIPFYRAEEATEAIKELLGPLYHKESRSFIGQLWETWTTCKYVEADPAVPGALKWATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NA88</accession>
    <name>A0AAE0NA88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_482094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NA88"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000228">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3375179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="321" mass="34946" checksum="87CEA57DBB2A16D8" modified="2024-05-29" version="1">MTAAQKMEGGGGGRNKVAYLGPVASYSHQATKSVFSPDQKWELEPTVTIKEVFDVVQAGDADYGVIPFENSTHGTVIFTLNGLADRAGSYADLAVCGEIYLDVHHFLLGRRCFGGAAAGDASLKHIERVYSHPQAFGQTAAFFAKHLRGVDTIDVTSTSKAAELAAADTTGKSAAVAGEIAAETYALDVLAASIEDRDDNTTRFFVIRKGKERQEQQESSGKEGGDPYGNKHKSLLSFTVPHRTPGALADVLGFFKSRSLNLTSINSLPSLLEPFHYLFFVEFEGSRFDDPEGRVKAVFEDVERAALRSTWLGSWENQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBQ8</accession>
    <name>A0AAE0NBQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_219395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="228" mass="25639" checksum="918D850303228C44" modified="2024-05-29" version="1">MSTSQPPRPGPPPASISTIQVPPTLSRFDIPARQYLSRHNSPWDGVAVGALVFCPSPESTDSVLLIQRAAADSLPNKWEIPSGVVSNDPAKDATITNAVARELWEEAGLTATAIKRLVTPPREEEGFVFSNSTNTKVFCRFVFEVELEVEKWESVRGRVKLNPVEHQRFVWAPEDAVRKMLADKAVFHGGKEEMLELTSRHLGELILEAFRLRKEDKEKRREDREKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBW2</accession>
    <name>A0AAE0NBW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_452097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15470" checksum="C13EDBD1627DE642" modified="2024-05-29" version="1">MAENGIREESFPARSKQVTGNVNGIPTEVSLMSFSDKIVLSVSQGGRLAQWVQVPLSAPSSASVDMGLPAAASSVLPSMHLTPKTLLGSGDRETLGQLYASQIASHLCLRDPEERRTLLLGLGLEKAESSSDAFFDLMELVQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC30</accession>
    <name>A0AAE0NC30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_480096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC30"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="66"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="458" mass="51308" checksum="E0667DD44990FE80" modified="2024-05-29" version="1">MVTSRSMPAELMSDLAIRPAPREIKINNPETRHKHSRSSYSEASPLTSRNNSLIFRPAKRPMQSPDKTIAVINASGRQAASLIRVATAVGYHVRAQLRNLEGVVATEVATNPNVTVIRGDLYTKDLPTEQVQVDVTRNGPISGIGVNHKLMADLFRGAQLAFINTTFYGNEQKIGEALADAAKKAGIQHYIYSSMPDHHAYNKDWPSLPLWASKHKVEDYVKKVKLPATFVYTGIYNNNFTSLPYPLFCTELQPDGSWVWQAPFHPDAKLPWLDAEHDVGPAILQIFKDGVKKWGGGKRIALAYEMLSPREACRVFARGVGRPVRYVRGPIEIKVKIPEGYRCQLEALEELYALGKDDPKKQPPYFGDIELEESCPEVAMQLWEGPRGLEEYAREVFPLEEHANGLTWMLEDEDTAGNYHHNAAPLSPASEHPDSEGEDDEDGLIMRGLNRNDEEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG79</accession>
    <name>A0AAE0NG79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_474615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12063" checksum="52A03D97EEE26703" modified="2024-05-29" version="1">MSAHNILLLGGHGKVALHLSLPPPVARVGHTGVIRNPDHVADVEKLRGEASGAEDRLTVPVRSLENVNMEVDAKGILDEVKPDYVVWSAGKFLSFSSFPPHEERRKEHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH22</accession>
    <name>A0AAE0NH22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_200229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH22"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18657">
        <property type="entry name" value="CSD_Swi6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3381320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="265" mass="29831" checksum="34106366664F8541" modified="2024-05-29" version="1">MPPAFSDNEEGSDVEAPVAVKKSGREKKPIVYKEELPDDVDDTPTDDRNGDAAENDDEGEEEEDADDDDLPEEVYVVEKIISHMIDDEGKPRFEVKWEGYEKKSDRTWEPEENLKDNAYLALEEYFRAIGGREKLFVDTKEALKGKKRGRPSLGSGTPSSSGGGKRSKRNGDHPLDADPPLSARAAAWKPPPGSWEDHIAQLDACEDEETHQLMVYLTWKNGQKTQHPTSVIYARCPQKMLQFYERHVRIIKKDDGDGDSVTTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHK0</accession>
    <name>A0AAE0NHK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_209196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="300" mass="31243" checksum="EFBBFF295E7D46EC" modified="2024-05-29" version="1">MATPINVEGLFSVKGLVALVTGGGTGIGLMMANALAEAGAARVYIVGRRVDVLQAAAASIGRPSVVVPLYCDVTSKISLESIVSVVETDMGFLNLLVCNAGVGGPQVRAPGPDTSLDEWRDQQLSFDFDEFTNTFKVNATSVWYTSMAFLKLLDSGNKKGNVVQTSQVVVTSSIAGFNKKAPGGWAYGPSKAAATHIAKQLSNVLPTWNIRANCICPGLFPSEMSAPIVNQIYAANVALAAGGAVDPSVDKTSIPLGRMGDDLDMAGQILYLASRAGAYCNGNTILVDGGRLGTFPSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHV1</accession>
    <name>A0AAE0NHV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_214299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042051690" evidence="2">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="276" mass="30035" checksum="F32DEFFAA4503293" modified="2024-05-29" version="1">MKLEALIAAAAWVSSAAAITGPAIPGGGATRPEGKPAKMENWKWSDPFSGSRIRKLEAACEAERTFKASEYLLDDLSESPPLGLKPFFDALKKVFANREYPGSWDGIDPHGYDRNLLKMEYVDVPIKVREWIEEQERSDGPGKGLFAVYEKPVSDDDVVRNTVRIPATPIFAALRPLDKKKVVIFAPGALYETLPLWVAEGSDCADAFQDAVKYTAKPADGSVVAYPTKKTKADRKAGKRDMEFTIKAQLLKAKQEEAAAASEDSAGAAAGNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHZ5</accession>
    <name>A0AAE0NHZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ent-kaurene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_561415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHZ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112169" checksum="73056A0330435CE2" modified="2024-05-29" version="1">MVDEFKEPLYSHPKAESSVMAAPVKQSTVENPIDIFVIANAAGKNPEDTDAKMETARRDDIPDTTDAEVRNGQNSDTLATAADDSNLFQIHIDESLALIKELGQKVNILEPFGSFSTSLYDTAWLARVRTPDGDWLFPQCFQHLIHTQEPEGGWPIYGADTDGIMSTMASLIALRDHYRHNPENASIPVPRPLIGERILLAEANLRHRLQVWDVALAVHVGFEILVPSLLDELELDDSIKKFEFTGRPLLMSMNQRKLRKFRPEMIYDPVTTTLVHSLEGLVGKIDFDRVSHHLTHGSMLASPAATAAYLIYSTDWDPAAESYLRSVVANGSGKGGGSVPTAFPSAFFELAWVTSTLLKTRASTEILALPDAVKISAFLEYQLERHGGAVGFDEGLLEDSDDTAKVILVLRLLGIRVFPKRLIAEFEDKDNFRTYKYEMSVSLSVNCNVLAALVHCQDPETYHSQIVKISRSLCRDLLSGNVRDKWNLTNGYSFMLLSQAFVKLIQIWDSGLIGQLPEDLIREQIPIALLHTLLQILHTQTSAGYWAFKNHESLEATSYAVLALNALSTLPWVLYIRPQVLAAIRNGAAYLAQHRDEWRQDEHLWVAKVSYALPTVARAYIIAAVGADSNTSHAWGTKATTIVTVPNNALRSKALHYSKKLACFAGDEPLDKDGIIFAWIAMNRRHNYPLPNTALRDMMKLFVLMLDLDERMKNVFSELGSPERLEFIRELRSALPKIISFDDGEPQPAPNGDNGKARNGTDVDNEGINGDQENGHQDNDKLAAVMADLRRYASHILDHPAVVRSSADIRIQLHNQMLNCLFSGLGLEETYTRLATPEQDTLANGATDLPCDVASPGVQSTVGSKSQMPVALIFLTCIAASPADEDFFRGLRGRFLLSVISGHLTTMCQHFNNWATVAPDPAEGSLDSFNIFGYHLLFGWDGVQRHPKGKTAISPLKKDLFLLLEYERGCLNQALDKLEAEMKGKQKETWKMGAIKAFLEMVDVYRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNE5</accession>
    <name>A0AAE0NNE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_471440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNE5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="673"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3384747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="899" mass="100235" checksum="C87D77A63CB3F092" modified="2024-05-29" version="1">MPPQGAKMQGPQLPLHLLKELGASDSQSRQKLDKHWPQQNRKEQRKTNRQQRKVERVSASRIHHAERVIPSRNAKAKTPRTTAASRTSKTSVKAAVPTRRERKLFSKKRAPELDDEIIENPFSDDEVSSGDFDDDFYDSDSEEEEQPPPQPHPLSRKAALPKQPDSSKQVESPGQAAVPRHVKEKLAEDDAEIADLERKLGLKGRKTLPKSFQDDGLGELLGELDEGHADEEVVERKKRKAEADDWLAEKRRKATEQNAKQERPAPDSEESDNGFGGFDSDDMDEDDMPDLGSEGDKLDDDDSQDEGISGNSGNGSENKAPRVRENPYVAPTTGQKVAKYVPPSLRQETGSDAELTGRIRRQTQGLVNRITESNLLSILGDIEKLYRDYPRQHVSSTLVDLLLIQVCDPTSLPDTLIILTAGFATAAYRVIGMDFGAQLIQDVVDRFSNYYNEAALAAIERPDVSKQTSNLITFLSKLYGFELIGPNLLFDYIRLLLGDLTELNAELLLRVIRSCGPSLRHDDPMALKDIISLIRPAVTKIGEQNLSVRTKFMIETINDLKNNKMKTGIGASAVVSEHTTRMKKLLGSLSSRKLKSTEPLRMGLKDIQQSDKKGKWWLVGATWAGPAAKEKTSDMKAADEHESDDDDDSILLSDVDGGPDLGELAREQQMNTDVRRSIFVAILSATDYEDAYLRIHKLRLNKERQREIPNVIMQCSGAEKQYNPYYTLVAMKLCSDRKVRWSFQDSLWRLFRRLGESVFGDEAEDEDEDEAIDTRRLVNIAKMFGSLVATGGLGISIIKCLNLPYLQPKTRAFVEILLIAALLKCQTSENPEDAISAIFRTAESVPDLARGLQWFLKKVVRKSDLAGGKANAKQLKEASKTAEAILEIALSAAQGDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNQ8</accession>
    <name>A0AAE0NNQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_172313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="35347" checksum="5C9F3E1C0C309CA9" modified="2024-05-29" version="1">MSPVNVPTTIAGKAVGPIGFGMMNLTLFGGIPLDEAIKPMKTALDNGANFWNAGTLYGPPDANSLHLLKHYFTAYPSDASRIVLSVKGAYNAATHTPDCSPEGIRASVDECLRVLDGTKTIDLFECARVDPKVPIETSIATLAALVREGKIGSYGLSEVNAEHIRRAHAVYPPAAVEVELSLFTRTVLAQGGVVDTCRELGIPLVGYSPLDRGWLAGSFKTLDDLAADDFRRGWPRFQPGAFESNVRLAEEVEKVAKRKGCTSAQVAIAWVVKQGVLPIPGSTKSERVAENMKMVELTGDDVAELQAAVDKTEVVGDRYPAAFQEYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP03</accession>
    <name>A0AAE0NP03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">B0H63DRAFT_176180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3385003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="17264" checksum="2ECC7559621CE4AE" modified="2024-05-29" version="1">MATHLPEGLSPDSVDTLSELTSIIVKLRSSQASAGGGPGSTPALGNLPGLPNMPGSGATPAAATGGATPSQGGTTIGSTPLPGGGGAGMLSVKELPAATDNLKHKLQRARVAVKSLPDVGRTIAQQEAEIAELEERGRKQVAMLAKIKEEGLQFVCTEQSSRDEGERMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPA6</accession>
    <name>A0AAE0NPA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_395689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="199"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="28794" checksum="CFED86B0DA5D4E8B" modified="2024-05-29" version="1">MATQKKGSKPPFWLGGAAASMAVCFTHPLDQTKYRMQVLQTRTTMLSTLYKFAVRDGFISLWSGLSASILRQSTYSTARFGLYNFLSRQLQQHSGISKSSTASTIVCAGVAGGLAGMVGNPTEVVLVRMCADAAKPPAERFLYPDAATGLYRIWRDEGVKVFGRGLSANVVRSVLMNVSQIAPYAAAKRALLARTTLQDDIRTHALASLFAGTVATTACAPADVLKSRIQSAAKGSSVMQVIREGIRHEGPWFLMKGWTPAWLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPG1</accession>
    <name>A0AAE0NPG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_543600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPG1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041963922" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="19956" checksum="106984DF70EF0C68" modified="2024-05-29" version="1">MVLFKACFLGALLGVNAAAAPSPTGINNRSCSAASFANTTDFILREYTIETVPSGSLGTFAIENPGTGDVYRLYRVPVSTGGGTWSVCRAGDEAPLPSVLARCQYLIERWTGGRIGFRFQWYCDDKDPSKPLLFDATVIGELPNEVCVTGNATAGVSRSCGLPDAEPVLLSVANISWEPTPTEAEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPG8</accession>
    <name>A0AAE0NPG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SprT-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_472351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPG8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="366"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="612" mass="68714" checksum="6CB8B0688E6047CF" modified="2024-05-29" version="1">MARASKPVKDRSDDDLDDEFPDVATLALRMKQLKQKETTGPGNGEKTKTTMAAATVRRRKLGGLVDTPLLRAWTPDKEMVDAALKAKRESETRPPRVQLRARKLKPLVIASPDMDAKNDSFSGEEEIVEAEQVSEGEGTCASSESGDESSEFEVEKSENDSDDHDDSLADFFSRWRQPKREVQIKAKETQPPKSRVKDSGLPPVGRPRRNLLDKPSRDLQNKVPKGLVLEGSKKVIAERDLADTFSDLQINDEKPTEADKSRPRGKVTPPSTPPKPRRGLVSPTKLPRIPSTPHHPTSDLFWSRDFVDDWNDEHSPKKKLFPDAANRSPEKSQPSKKIDAAKMALDRNAKMAFQKDKQQVANNFLRELDTVLTNGEIGRLAESTGGVKIVWSKTLNTTAGRANWKQSRARTKQPDGSETTRIKQTAFIELAEKVIDDEHRLLNTVAHEFCHLAVYMIDKVLKHPHGPEFQQWAAKCSQTFADRGINVTTKHKYDIDFKYRWKCVNCSLEYKRHSKSIDPERQRCGACRSTLQQIKPVPRATTGKPNDYQVFMKQQMKLLKAQNPTSPQKDIMKMVASRWSQKGAAAPRPITPSEAMGVGKATDNLVGFDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPV1</accession>
    <name>A0AAE0NPV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_183712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="259" mass="29358" checksum="5FA648CF48A5B5D9" modified="2024-05-29" version="1">MGAAYVVGDSSPFMKRVLVPFWVVRIAIMIFEIGVYGLVIGILARYNRKDRQYYTKTTVETAIAVAGVMIGIILLCLILDIVCIVKRARRTLSPRFFLIVNVIQTTIWVVLFILSMIGLSSPLGFIIAIVILLSFIGLLIYASVIFHRFRKGTIVAAYAPAPDNEIHNLQNTSYSAGYPSYPSHSHQPPQQQQQGVHGYEPSRHRDIEGYGDHQQPYLPQQPQKQQEQQQQQQQAPQEHQKTSYYEPQPYAQELPGRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ09</accession>
    <name>A0AAE0NQ09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_522864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042121320" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14554" checksum="93CB60AEF71F3959" modified="2024-05-29" version="1">MPNQHSLLRLLIGIVCLALITNTGSLVHAISPYESWICDYQTKDKCILTLTIQKDESFMRADHFDRDCNHAGLVDGMKWNRWSEFHTTGGFVPNTTVRVLPSYSLTTASRHIERSSKTTSSSGQTAIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQD5</accession>
    <name>A0AAE0NQD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_187295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="755" mass="81027" checksum="73772F37AE10150D" modified="2024-05-29" version="1">MAHYGDMAGTWAIAGEVAHPRPESFFSTQSTWDSIFDPDERQRVDPHDWMDGGKYRSIVKLQIRYEGQSPDDSRYAIGTGWLIAPDTLVTAGSNVYDWYSNGETGLGKAVHIKAYIGYHGMKNINSPIVQTRLAKKVVTTGEWVSSGRLAGSRHRDIAMIQLDKPFTGNFRVFAYKKTPDSGDKRIGIVGYPADKTHSEERGAEMYEEYQNTSWNLEKGDENPLEMLRYRISTYGGQIGSPVLLKSFTNTAAIGTHVWDRGDWNLASTIGGPHGNDYDALLKALQSERSAVDQDIKLVKLTASSSTGGSGSGSDGFNASQRLPDFRPRAHSPDLSSEEAFFDVLKTVSMAVIGGGTAVTRGFAANGPLPKVVSPLLGPLGGPLAAIAGAALSTISWAAESQTSPVADHLSSAPAWSGTYEPSEGATERAILAEAALQTVLHMSIDSEVHEKVIRGMREKYTAFAPSVKIITPQLAPALIQSANQIAADGAFDEKNKQKILPARSLPDVESADLGSGGNNFLEMMLLQPSKPLGNDETGFFEELGSFLKKGLNIGKPILRDGAKKGIELLSGLYGTRNGYSDNSMSMAAAAETSSLSVPPGSNDDLKAAEVVVKRALLGEAALLALSELKGADLRTLEHENLKQSFSMDTEYEENFFDFFRVVVQKIGRGTVQKIGVGAVQKAVGLVVNDILPATVEVLAQQKLQDRANAMVESPASGGPRGPVKKPASIPHDELQEKPCHRGSACKAAPVKAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQI9</accession>
    <name>A0AAE0NQI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_494540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQI9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="509" mass="56939" checksum="A72F063CD57D07B4" modified="2024-05-29" version="1">MGPTRPVMVGWGFGYCNTLSALSSNIFSIALSRSTFACGECRRRKLRCDGQKPKCGGCQDSALSCQVTQRGVRGPKKDNLSALKSRLVQLEGILQTRLGDRAQVEGQRHNAHPEPPIESPDPPTVPNAQPQPPATSSISIYSLHLTAGVRAELDQLYFDRVHPAIPILHLRRYQSWSRSANKTNTLLAIHFRDMSEALCNETKRLIDSVSVSGTEPGGNDTEVAQASVLVTTGEMSAGRAFRIIQGLRLNEIDLPQNNNLAHLLPPQGRDFIDAEERRRVFWMAYLIDHLFSMRNDWPVTLDEHVICIRLPAPNADFQGGKHVLGPFLSEAMTETVAKDRSTFNECLIFVTICGRSLLAGQQYNISKAYGDIASDFWSKQRHDPLLLLAHILGQATFVYHCKCLTQIPVGIRTDSVMDVQHQALAAAERIVEYAKALPSLHFSKVHPMMTIPLFATTEFLYFNCNREERFGVLLQQLIDIFSQLRNVNNLEESVIELMSHSCKVLEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQU2</accession>
    <name>A0AAE0NQU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="229" mass="25251" checksum="0D0C12A7C6591A20" modified="2024-05-29" version="1">MLAEAAQLFSEHYGIWGTPPPGRQGGKSGTRVKLSGPRLRSQCLPAGARCSYVSVTVDGTLAGNAFACRWDYQGRQVCWVTQLVVHRDYRERRLATRLLEKLRETDDEIFGIMSSHPAACIAISKACAEHTAALMAGSPITYVKDAELRGSLFSMPSDEAGDLVSGVDSNFFVDHEEPLAALAWLQEENFWPLGNLPDGHEFLLVFESSRRRRSRSLSRGRYGQVSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT98</accession>
    <name>A0AAE0NT98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_448182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT98"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042055186" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12534" checksum="C99B3306BEEACF7E" modified="2024-05-29" version="1">MRTTTTLVFIAGLASTAFGAATKMFDDDNCSNEIDKVVFNGFANGDAPIPANVKTIRTDSISDIWFAYQRNDGSGCKGDLLRRLDNNQCIKVSDLGIGCTRLCFTGIGAASCSPSTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTF6</accession>
    <name>A0AAE0NTF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTF6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="43404" checksum="8B5A34DA8B47650E" modified="2024-05-29" version="1">MPHFPSTFRSRRNSAPPLSPFDTANNIPDRAGRMSRRRPFSTLMKKLANLKAGSGDANAKQSSNAKKPKSKNNNPYPQSGRLGVPVPEQDSHYSLSTGRSGRSSSVTSLGQGESVRLSTDGQPPPTTGGRSMAPTISTDHDTSTGLSHGASSVAGTSRTVNGGIESRRGGDSTFSSPAPSVRSLTTTLTTIQSMAPNAGAASQHNHANTNHHGQQSSSQVIHFNQPFPTASPASAIPAHLTPVGTATGTGHPTTYASATANNLLTDNASILTLASSSKRRRRRSFDTDASVRALAPSSLFGGSRESLPLSILSANMDGPIPTTPGLHRGASGVANERTSIYSATGIMASERNSFYAKQTIGTGAGGATQGDTVSIRSGLLGHGRADSISGSIGGGLGPTSPLASPREKQGVEEKDEENAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU29</accession>
    <name>A0AAE0NU29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_448308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU29"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="26304" checksum="9416771C98CF65CA" modified="2024-05-29" version="1">MDYRENLGRKNMFEAHEEAARTYITGKEHNSGAPMFLPIVAQLPGDGGCFCSRMSGSSKWSNLQLYLTKLTYLTSTANTLDTHLMKLRGPESIHASSAGGFPCFEHRPVPAVAPEWVFVQQTVVVRLSRVDKGRDQTRCKQQTMTESDRAEHGTTPAARATDLADDTRDRGSSTGEILQLFAWSSFPAFQRFQFRGCCRHKGIPYPPTTLNLVPSFKNHRKDQKVPTTKIYSADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUD5</accession>
    <name>A0AAE0NUD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_559337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="480" mass="54750" checksum="C2BF4E6B7A7CACA9" modified="2024-05-29" version="1">MDFDRTSLAWSDHDFATFKCGLKGESTVITKLAAKERIDHQTLSTKEEWKAWFKNASFLNPREQTPGLCIVLCNRAEPVFDGVQSPVRYLPFEQQVLFQLVRKFHIHPRITRTIGREICYFSAQHHLSDDVQEYGDDEEDQRPGPLITYTARTSSQLPDDLALSSTFILESGLSLAVIFGCNEKQKKSIVSRMERCDLAYNHPMLLPGLFLELERTRLGDAVEVLLDNFALRGNSDRELDLDMDKERMTAFLKSSYASRDLANQIQAVKRQLGKMMMAMSGGVVDEDPFSNTKSSEYGLSSRAGRQIRVRMEDIAYELDDRINDCHLMMNNMSLTMQTVWNHFARQDNLMNLNLSKVNTHLARTNTGLSQDMKRDSSQMRSIALLTMVFLPLSTVASIFSTTFFNWSPSEGESFVSSYFWVFAVVALALTGIVVGVWYLATRAHHRKEINNNKDKDKDKFSGVFGEDEEKNIGFVNMKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUD6</accession>
    <name>A0AAE0NUD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bulb-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_500880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUD6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="117" mass="12860" checksum="71845E770A805728" modified="2024-05-29" version="1">MSHNTLGNGEWLKVGQSLFSADGSVEFKMQEDGKIAVYWGGECRFQNTREQSWGNIKGVKMQEDGNLVMYDNAGKAVWHTDTAGSKGDSTVICAVQNDGNVVLYKGTPIWSSDTHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUR5</accession>
    <name>A0AAE0NUR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_471130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUR5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="12754" checksum="C8B5D21D6DCA9F4E" modified="2024-05-29" version="1">MSGLFTLDFSSPSIKFIYACKVSETKHITAMPATPSIASSAASIASSQASSASWSENVLPKKYRDPLKLKETLNEIYGEGQYRVKIRGDRFIVALPRPMLEGELEAINKGIYHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWU3</accession>
    <name>A0AAE0NWU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_463060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="41275" checksum="2A32AC672D988FE7" modified="2024-05-29" version="1">MEYFVPHSFSFHPALCYIASRNMTRIAIPPPTAGGRVLLTGGTGFIASHVLDCLLDHGFDVVVTARSEEKGRRIVKSLDASLGKKVSYVVVENIARDGAFDEAIKSDPPVDYVVHTASPYQFFFDDPIRDCLDPAIKGTTGILKSIKAFAPNVKRVVITSSSAAILNPPHHREVYDENSFSDVTMEQAMDPDHTYRASKKFAEAAAWDFVAKETPNFDIATINNTYTFGPIPRSLSSANNLNTSNHRIRDLMEGLMREKIAPTAPVFTFVDVRDVALAHVRAMIIPEAGSKRFYVVGGFFSNPRLAGIIKAAHPELADKLPPQEEIDKDDFPDGHWKFDVSRSRKVLGLKYTALEKSVGDTVDSILEFKQRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY53</accession>
    <name>A0AAE0NY53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_537826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1325" mass="145719" checksum="F616E9329AC71CE5" modified="2024-05-29" version="1">MSSTSNPTPTVTVDGTSSLGTQLSAGRYLDVLLSDPAQPLIASFVGALLGSDTKTPSESQTYQNTHDEITTIGLCAFNAFLQANVTGPVLDTAAVQRVDDVLLQVSPTKEGVSKTQRLSALRRACFKSLDVDGVSVYPYIPNIELFCLARFIFTSTSSSITATTHVLQLTEKDGQEQDIANRSLAWLALRIHVWHYKLITQPSLGPGSVFTKGAQWSDVPSLQHAVDQGLEALEKEVLIQDGGWNAREKAQFLVEKANVCIMLGQDVKAREALRQATSLNGLVYALSGALGKRTKFQQNSTSQLVVLAKSGEANETANGTDKEAREFKPQSVALNDDTLLESLEFTRERVEDLDAAVDKKVDVPEALKDISPNEQPQLSPLDQIILLTEATLKDSFSPADTLNSEEILPYAVRVISDKSTNWQIYTQALLVRSRIEMHRSRTIERGVLQMQAVVDQVIVDTTSAPAKAEVQKETKSKTDIPTLQVTGDGEQANETKDLAVSNKPTSFFPVAKPTESAPAQVRLQYIHVLSSPPRWHLESELAYSWAGVGSLVSALEIFKRLRLWAEVALCLASNAAREDEDGRGSGGEAKAKAIVRWRLFRPTGSSADETTDDELDEDIDVSELSESDFQGPERSPPPFNAPRLFCILGDLEDEPAYYERAWEISKLRFSRAQRSLGEHYIKQQELKKACDAYKKAVAVNRLSSDMWNRLGDISLRLGEFSDAVEAFGRAIACADNNIGGSDDARTWSNLGSALYSLYVERVKELKAEKEAKKEQAEEAPTPVVVADDEEVSTEERAAPRSDPATLLSQSLAAYKRGASTAHDNWRIWDNVITLGSRLRPVAVSDIVLALQNVIRIRATEDALDLDVLRLLLNEAVLSQPKTNEKTTAYDSPRGSLERSVCELLEKSVAPIITTRSELWEIIVRERVWRRDYAGAIDAAEKAWRAAVGGAIGGLSAASDGKTSWLESKEGFQTVLERTEELISALENYGDEVPEIGSKWKGKARSAVRSVMGKAKENWEGSEEWEKLTGLLEGLSKQPASCLLLHNDNRDNDRLDGDVEAGVLALGDGGGANIRIRRGRGHHAAPPVLRISSLRGIPPPFHPVELLDRSRVIPVFRHFKSVQDVTLGLSSDKINDILLDLRASNSYPDLINFRLKFYRTAKARAAYACTQSSGGEIPKRFAEYCETHHEYLEATVEEEEIEKNRLNNILTRARMLVSSIKSAAEGGSLEEKELGALKVKVETLRTCYPDAYDAGNWINSNSRTPVDNSPGAESGSHTRAFINFIVPTVSLLACIPEVLAWWRGSPEPGYFEDADFLQLIAGSAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYX9</accession>
    <name>A0AAE0NYX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_492782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="558"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="781" mass="84414" checksum="79526509C30DC293" modified="2024-05-29" version="1">MAAPSSAGDRVKRFFGIDPDEKLDDSSYYDDGSFVEREPSTKDFLLQLAPTLAGITHYFRELFPFLGWIFHYNLTWLLGDFIAGVTVGFVVVPQGMAYAKLAQLDPEYGLYTSFVGFILYWAFATSKDITIGTVAVMSTIVGNIVLSVTAAHPTIKREEVARSLALVCGIILLFIGLARLGRIVEFIPLVAIAAFMTGSAISIASGQVAGLLGLQGVNTRDATYLVIINSLKALPTAKLDAAMGMTALFGLYFIRGVCSYMGKKQPNKKKLWFFLSTLRMAFIVILFILVSWLANRGVTDIKKAKFAILGTVPSGFQHVGAPRFDSEILGAIAGDIPTTVLVLLIEHIAISKSFGRVNNYIINPSQELVAIGFTNVFGPFLGGYPATGSFSRTAIKAKAGVRTPLAGIFTAIIVLLALYALTSVFFFIPSAALSAIIIHAVGDLITPPRELYKFWITSPIEVVIFFAGVLVTIFTTIENGIYVTMGASAGLLLVRILFITDGKFLGKVDIATVARDDVRGGSGVARGPAEGEGTHSAFIPLGRSDLSNPALDLKTPYPGVFIYRFSEGLNYLNASRHVDFLTIEIFKHTRKTELNKFSKLGDRPWNDPGPRRGADPNHDEIAGRPTLRALILDFAAVDFLDVTAAQALIDLKNQFNRYASPDRVEWHFAGVANKWTKRALVASGFGADTIHSDFGKGDSGPLLAVGDSANNTAEVVNAIEKPKDIEGGEITPVAATKTNSGGARLVPIYGINRPFFHVDIETALKSAIHNLDGRSKYAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZL9</accession>
    <name>A0AAE0NZL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_465960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZL9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="47433" checksum="8A89306D18A8EA3E" modified="2024-05-29" version="1">MNSFVHFSNTHMNLSAGVFNLLKQQKVFSPFSSLLFVQARSASSQFSRISAYLAVPAKQQSQKSLIRSFVTTMAAKETKITDWVVPSDKSGEFKRQQSAFRNWISKKEGAEFPAEKGRYHLYVSYACPWATRVLIARKLKGLEDIISFSAVHWHMGPQGWRFVTSEDTDAEGNNVIPDPLHEDFTHIRQVYFQVNPDYQGRFTVPVLYDKVQKTIVNNESSEILRIFGTEFNDIIDEKYRSADLYPEALRKEIDEVNEWQYDLINNGVYKSGFATTQAAYERNVIALFEALDKAEAHLASTEGPYWFGKQITEVDVRLWVTIIRFDPVYVQHFKCNIRDIRSGYPALHKWMRYLYWQLPAFKDSTNFLHIKAHYTKSHTQINPHSITPVGPLPDILPLDEEVPAVKFAVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZY3</accession>
    <name>A0AAE0NZY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_124969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZY3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="389" mass="41869" checksum="6BC9579B64EB650D" modified="2024-05-29" version="1">MSFTKRHTVLSTPRAGHAAAQARPEKQFPHQLAPGLRPSPVDGRATTSTGTASLDQLLAGHGGLPMGTCLMVEEQGTTDFSGVLLRYYAAEGLVQGHQVHVVGFPPDWKYQLPALAVPDTKSKSTQPAAPPEEKMKIAWRYEALRNADTGVAAVRGDGSIFCHSFDLSKRLSSSSCKGSLFSTPTTGPQTLNSAANSTTSPFKAIIKHLRTMLGASPPTEIHRVVVPNLLHPSMYSSMCSQPAEVLQFLHALRALLRQYSSQLTALITLPTSLFPRRSGSVRWMELLCDGVVELIPLPANPAAAEPSAKKDGRNDEQPQGLLRIHSLPVYHEKGGGGAETSSEFRENLSFSLSASKGLVIKPYSLPPMLAEDDQKEKSPASTIKDGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P018</accession>
    <name>A0AAE0P018_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_519765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P018"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="331" mass="37672" checksum="99A547D5E843E5CC" modified="2024-05-29" version="1">MDPNSLAGQAPNDSAPESDEVMSDYAPSLGGESTFGSLTSSVNGHVWEYGRRYHVYRYGRYPIPNDEDEYRRENLRHVMFKELLDGELYLAPIGENPQKIIDLGTGFGDWVIEVGENFPSARVIGVDLSPIQPLWIPPNVEFIVDDVEDEWVHDSDFDFAHLRFICTVIKDTDALFTRIFENLKPGGWVESQELFPELGSDDGPLPPDYAPSRFYKMCGEVLHQLYGFNTGVAGQLPDDLKRLGFINVQRRVFHLPIGDWPRDPHLRLIGGTFREVILEWVTAMAARPFVEAGIDKDEIDEMVENIQNVVRDKHIHAYMPVHYTIAQKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P092</accession>
    <name>A0AAE0P092_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of Vps4 activity in the MVB pathway-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_130074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P092"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="305" mass="33625" checksum="3C59FE48B82194DF" modified="2024-05-29" version="1">MPPSSAVLVTKVKVQLKLAIARLRMVQKRDEALAKQQRRAMAQLLEVGKIESARIRVENIIRSDIATELHEILELYCELLLARAGLLEAPTCDPGLEEAVKSIIYAAPKTEIKELHTVRTLLAEKFGKEFVIHAMDNTDGKVSEKVVRKLSVTPPKEELVVGYLEEIAKAYGVDWPKKFKKDLGDPPDFLDDDDENTNGGQAQKNLDVPLVPVDDDDDEAEARAELSKATPPRTFGPASPLHVNPPSPSTENIHPKVTLNSLELKPSKRPTKVSAVAKVAEKKDDIASGIPDVDELAKRFAALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0B4</accession>
    <name>A0AAE0P0B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine incorporator/TMS membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_390196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041979733" evidence="8">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3391019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="480" mass="52491" checksum="7DE26345B0FE7825" modified="2024-05-29" version="1">MGALLSIPLLAVPSVGTLLTFGASCCGAATCSAVCSMCGKCGNSVATRIAYALILLVNSILSWIMLTKWAVEKLQHLMLDYVKISCGDGNCYGWLAVHRINFALGLFHIILAGLLLGVNSSKNPRAAIQNGFWGPKIIAWLSLIVLTFLIPDSFFLFWGNYIALFCAMLFLILGLILLVDLAHNWAEYCLAQIEDTDSKVWRFVLIGSTLSMYVASLAMTIVQYIFFARGGCSMNQAAITINLLLWIGVSAISVHPAVQEYNPKAGLAQAAMVAVYCTYLTMSAVSMEPDETEDRHCNPLVLGQGTRTTTIVVGAIATMLTVAYTTTRAATQSFGLGGNGKGHIRLSDEDEHDLVTTQPSGRREMRAEALRRAVEEGSLPADALLSDDDDSDTGGGNTTHDDERSSTQYNYAMFHIIFFLATAWVATLLTMDWDDKKQDDFATVGRTMWASWVKIISSWICYAVYTWTLVAPIVLPERFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0L0</accession>
    <name>A0AAE0P0L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_520249</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="54"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3391054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="383" mass="41186" checksum="B7B47EC0759BA38B" modified="2024-05-29" version="1">MLALRSIAAPAQRQCLRAAPRGVVTMSLQNQRFYSSKDSVAKFNGTKDSSGLYTVSLIEGDGIGPEIAVAVKDIFAAAKTPIKWEPINVDPILKDGKTAIPDAAIESIKRNKIALKGPLATPIGKGHVSLNLTLRRTFNLFANLRPCRSVAGFKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRYAFQQAQAIGRKKVRVVHKATIMKMSDGLFLSCAQNIAKEYPDIEFDAELLDNTCLKMTTDPLPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSMMMLRHMGLGEYADRIEKAAFATLAEGKALTGDLGGKASTQDFTSAIINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0X9</accession>
    <name>A0AAE0P0X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0X9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000050">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="167" mass="18446" checksum="3A1CB4F7A8A03524" modified="2024-05-29" version="1">MASIGSLQRLSAESLSKLILAEQAAASGNDPTVAIVDVRDDDYIGGHIKGAINVPSRQLEAKFPTLVRQLQDKQIVVFHCALSQQRGPSAALKYLRERDRFAVFQANKAAVAASSSAEGEENKEDKQVEQKVYVLDQGFVGWQAVYGEDERLTEGYRKELWADGYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3Y9</accession>
    <name>A0AAE0P3Y9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_443238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3Y9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="286"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3392953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="514" mass="58885" checksum="860D679763F43D74" modified="2024-05-29" version="1">MADAALKPEKDFSKEADKQIPEAEQLAKVLPRLILLHCEICVADLIAQPQADIQAAIEKLSLLEKQTRQASDLASTSRILVSIITICKNAGDWSLLNDQTLVLSKKHGQLKQAITRMVQTVMGFLDQTPNLETKLSVIETLRTVTEGKIFVEVERARVTKILSNIKKEQGDIKAATDILCELQVETFGSMDRREKTEFILAQVALCIESGDWNQAGILSRKISTKYLSRKPKKTAEQLAKEQKEREKKKERGEEVPEVKEDDVTDLKLRYYEQQIILAKHDAKYLDVCKHYRQVLDTEAVEEDPVKLQAVLQRIVYFIILAPHDNEQHDLLHRIHKDARNSHISEDAELLKLFTVHELMRWPEVSKVFGPHLCSTEIFDSTEGQSGDPKAFERWQDLRKRVIEHNVRVVAKYYTRIQMGRLTKLLDLTEDETEKYISELVTSKTVHAKIDRPARIVGFAKPRDADDVLNEWSFNMKSLLGLLERIDHLITKEEMMARIQPGVKSKKGGKEKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P424</accession>
    <name>A0AAE0P424_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_498452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P424"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="83"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="607" mass="65394" checksum="DB7E193AE1C9AE61" modified="2024-05-29" version="1">MTSTASLSVQLRLAIEDKLSKLGFLEVPQIALTLAWVVVGGLVFWYAAIRENAKPIRYKVPSPKTPDKLQILDPPAIKVSGSSAIQCYAPATGQFLGLVNPSTPNAIDRAVEQAQIAQAAWATTSFRARRAVLRTLLQHVLDNQEEICRVACLDSGKTMVDAQLGEVLTTVEKLEWTIKHGEKALRPSKRPTNLLMAYKRNTVHYEPLGVVATLVSWNYPFHNLIGPVISALFSGNAVVVKVSEQTAWSSTYFASIARGALVVHGYSPALVQTIACWPQTASHLTSHPGISHITFIGSRPVCHKVAASAAKALIPVVAELGGKDPSIVLNSVSKGDLSRVVETLLRGSFQAAGQNCIGIERIIAPPGIYEKLVPLLEPRVRALRLGPEGDLGALISDSSFARLENLVSDAVRNGARLLVGGKRFTHPDHPNGHYFAPTLLVDITPDMAIANEECFGPIMVLMRANSDTVEDILRVANAPNFGLGSSVYGSESDPKLKQIVKGLKVGMVAVNDFGVTYAVQLPFGGVGGSGYGRFAGEEGLKGLCNIKSICEDRFAWLGIRTTIPKPMQYPIPSQERSWQFAKGVVTLGYGTTIKRKLEGLIGILKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4I4</accession>
    <name>A0AAE0P4I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_457716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4I4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="116" mass="12502" checksum="376B11E35B7BF294" modified="2024-05-29" version="1">MASRKEKDMRRPDLVIPYQEPASKGEGGDFGSTISSTLPMAAIFLRNKYIGWASVVFSLQSWLGESEETTKSTSTPGYFSVGMSLMSLVVTYLPLFLPQPGQPGTTTEAPAPVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5B0</accession>
    <name>A0AAE0P5B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_458463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5B0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="121" mass="13383" checksum="3832E21C74DC38BD" modified="2024-05-29" version="1">MASCALLARQVLLEIGVFNGRTSRIYFEGYGHRDKAAGLKPGHKVYHLASLSKSLTAAAIVLLVADGKLTFWNRICEVLPGFHHADETIAKQSTILDFLTHRTGLASKTSCCLGRTIRWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5J5</accession>
    <name>A0AAE0P5J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_458967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5J5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="646"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3393731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="959" mass="109148" checksum="9AEB2CE31477099D" modified="2024-05-29" version="1">MASDRGNQLTALCAVASFLWLAHNLEGHRLIEKPRLSSLLVLLIAGISSFAVSFFAEWLPGANGRFDEDTGPLRVARANLPRKPRRFYLPGLVACIILRLELFHRVTSDLQCSKPAIEACLPLVLLAYELLPGRRRRPNSDATEKDDHVNFGQTMPEAIADWLSEARVSVIIGLLILVWGTYLASSQSLRSTFFCSSHDSSTLVVFLQWIGVLLDGIIAVLYWRILAWQRTTKSRLKTLSTILLASSMGTAFMYWAFRLAHQTRPMSYHFKGLGSLYMFDVFVNGLTFATFCVSTGLIVADGGPLSLACIITFLSGLFLAIQQTWLTGTWENATPTASYFALFLICVGFANFVYANNMRSVIFVHRVFVILFLGIIIFTATIVSIVKGHRVLDNHPLQRLIYDARVEAGRWLVHASVSNSLQVAVQEYKERHNGRDPPPNFDAWFMFAKERKSEIMDHFGQMEKDILPFWGMAPDRIRDNLRRAAAEPGIAVLKIKNGEVRHNVPETSPYKAVMKDLAEMVESFIDHLPNMELAVNLHERPRVLAPWEDINRFKATGRRKALTHWHADSQEPASAINQPFKSPDDRTIAQTKFTSVRAFREMMALTCPPGTKARSGVHWDVRDFCFSCARPQSSGQYLTDWSYSQELCHQTDLLRTHSFHMTPPEVRPLQEFLPIFSRSKTDSYSDILIPLRRIAEIPEDRDAPFPMKNPNLFWRGMVDYDLHSTSSELFHGGHQERLVHLVNNASSSDKTTMLLPKANNKEKFSYEQVSTTELNTLLPMDVGFFSGSKGPCSNSSNTLSSSCETAASHHHLEEFGSKLPDEPLGHQYVLVMDRDNGPPPDLMRTLRSSSVPFYASIFKEWYSERLIPWVHFVPIDLRFHALHSTLAYFTGFDNRPKVNGREIEMSRQLDDAQWIAEQGKRWARKALRKEDMEVYLFRLLLEWGRVLDDNRKEHKFVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Q8</accession>
    <name>A0AAE0P5Q8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_28534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Q8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="10">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3393799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="54922" checksum="DA06AE473B713625" modified="2024-05-29" version="1">MKKKHNDIDKMKTCILPALLASSAAAAAVGRASTSAELCAAKTSEENGNYFCQAVHQVTYSNVGFSQSAGFYEEVTHMDTKTGACTKQNKTFSGPMAPFNEPMSLHFRGPLRLTQLAVYMPNGQEKKREEAPSPRAAAPAGAIEHSEHNMHHLRDILKRRGGHHGHGHGKKRHAAEQQEEKKKRDDHPIIWVTATIDGKVVSWINNYWGPEATPAPAPAAVPAPAAPPVNVPAVPTPPAAAAAPKPTPAAAAAAAAPEVVEAAFVPGASSGSGSGDFVRTGYYNAAQGKSQGLTFLGNYGGQGSGEWTPVFGNTLSYINAAGTGGASSSTVLSDTLLPSHKEFAVMTDQPCSSSGSDCGYVQPGSVAYKGFAGADKTFLLEFSMPHDPSPPSGAGGYDMPAIWMLNARIPLTSQYTACSCWPSCGEFDIFETLAEGDTKAKSTFHAGNKKSGGDSNYFERPLGGTIRVAVVYDSKLATVSVKVLPKSLGAGDFPEELGDGELELLQADTGAAAAIGAASRFSLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P642</accession>
    <name>A0AAE0P642_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_32818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P642"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3394032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="251" mass="27469" checksum="33DF75A406273AD6" modified="2024-05-29" version="1">MAPTAIIAPSILSADFASLGEDCSRTIRQGADWLHVDIMDGHFVPNLTFGPPVVVKIRKHVERPTQSYGKGTFDCHMMISEPKKWVKEFKNAGCDLYCFHYEAATSSAAESPEGISELKTNPKELIRYIHDNEMLAGIAIKPGTPVDVLYDILDNPQEKERPDMVLVMTVEPGFGGQKFMASCLPKVEELRKRYPELNIEVDGGLGPSTIDQAADAGANVIVAGSAVFGAKDPAEVIALLREAIEKRNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6M0</accession>
    <name>A0AAE0P6M0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_42151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="529" mass="59475" checksum="5E5CF80505DDBC06" modified="2024-05-29" version="1">MCCTVRKIYTVCAHYREANQACARRKGRRRSWNVWSKFSSCKKSISTEIKFGFCRECRSFYQGYITKDVGAILNYWAYKNRHGYSDPVPAHLVPADVVFGYPAVNEESKLIRYELMAILYQLPWRIKNMNDWMRKLEEIRNLTLNWAAEPPPPPPFSTTPCHPGGSPSRYERQPISTPPLRRSKDGIDYTILSACRPRKPAPKRERNTFKSETMKARNGPILDKPQRELPDAHMETLRRLCGRVNNKDFNSWQSRDSMLKWSPRNSTCSLSSSHTRNTSTRHNKRSSSTANIIIKVQGATSKRRSRQRRRSSGCVSNDTTASATGTSAVEVGVVEGDSKNTFNDNVDAEWPLGGESSDPKPSEVPSLARHDSSLYQQSRFGASSASEHRVGSLALEPANPHNNNNNNNKLEAIEEEEIIDDLIDLYGGNEDPVPLRSPSPAPSEDAKPFDFDAYTDSLYSTDEKAEPERESDKPCMFARLQQVLSPTSSTLKGVHAALRLSVVSEDETAAEADKHAALPITITDMGKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6Y3</accession>
    <name>A0AAE0P6Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein CSN12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_45815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="256"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="522" mass="58905" checksum="49FEE4FFACFFCE88" modified="2024-05-29" version="1">MDSIFDKFAEAQLNRNGYRLAKTLSPDLPNEELYSIWNSCNAHDVRAILKRSIQNTATGMDKLPHQEVAGWVEVYYTYWKAVGELLAVQGPSVAYGKQFQPSSWTKVFAAWTDLLSALIRGYLSQGFEAWTIPCLYVAGKHLRVFAIKADDERNKNSSLDITAGGNFQDDFNPEAEQHAKLEDCARQLQKIFNLCLNDRAPLEESRKWGIYYVTNLQFKTYFKFNSAALSKNVLKAISAGRGDMPPLTAFPKSQQVTFKYYEGILCFLEENYVEAENHLTEAWNLCHKDATRNKELILTYLIPCHLLTTHTLPSQKLLEPYPRLQKLFSELARCIKKGELHAFDLALQEGEDEFVRRRIYLTLERGRDIALRNLLRKVFLAGGFEESKEEGGSPVRRTRVPIAEFAAGISLGSQETLDDDEVECLIANMIYKASKLYTARSRAPGSVYAQLVIALQTNGIQESSFQSCLASSILASLWRWRCLGLQGSTWTTRPLGLMKGYIARERGIVVLSKSGAFPGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6Z9</accession>
    <name>A0AAE0P6Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_426083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="95235" checksum="4FDF95D9414230CB" modified="2024-05-29" version="1">MMDRSRAMARPDALGSTSTAAGPQPHPGHPARRRKNHRGGKKKKTRRKSFAADPDDMAQDSANGEGLDGVGEGFYSRPGHNLSNTSIDSETLLDHRSQQAFIRPRRPSILATNSTGTRLRSVVVRDDSGDDDDSPEQWGEGAPLLSSSLYKKAETFGGYGSNDAPRKNGSDSRRDSSRGSSKRRFLAPFTSTGTDSYNVNYPPSVPGTPPLRAIDRMDMSFSDVLLRDDLDNGQRSPMRTVDEDDSRGGPGFQPSPLERRHTIALQAREDVCFPQDGLSDVADDDMGARDPIAYPARTRRRRGKWPDLSILDEWSRFEKEGRSEERRAKKITEPQLINGRLRPIHRGWFQAEEDAPYRFTYFNEEFQSTIHSQTISELVQPGSSTFKELFIPDPPLLSDSSDDEEDDDHNISLQQVLGSQNGEPRVPVRQPSLATTTQSYFDARRERRNSSSHHPHQHPFHQASHPPRPSTADKPGPGHETPRDAKSPEPSKSPRSPKAPKPPKYGDRPVWWLDILSPTEAEMKVISKAFGIHPLTAEDIMVQEQREKVELFRHYYFVNYRTFDQDQNSENFLEPVNMYVVVFREGVLSFHFSMTPHPANVRRRIRQLRDYLILSSDWISYAIIDDITDVFGPLIQNIEDEVDDIDDTILQLHSSTDPASKDNKKKDSEKPESGEATSAEAGRDMLRRVGDCRKKVMSLYRLLGNKADVIKGFAKRCNEHWEVAPRSEIGLYLGDIQDHIVTMTSNLSHYEKILARSHANYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIITGLWGMNVWVPGQQYEGDLKWFYAITVGLLCFGLGCYLIAKRVYNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P705</accession>
    <name>A0AAE0P705_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_45900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P705"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="618" mass="67594" checksum="A876790BA3FC1A13" modified="2024-05-29" version="1">MRVGGFGKPNTAGYEPIDGIDDDAGIHPKKPLADDHHQGLCHRLFRPHNIIIFVAAFVLSLVICLTVGFIAGDGTLFGIRTNANNAKAVGWQGEKSADVAGADDCPCRPAVKVPQYFQTTDGKWAGPTATGKPAFLAQTRTFNAAAGATFVPNDPLQTSLPIVGMNLSKDESIFRMMGFLAPYSPSPGFGVDEYPLPPGAEIVQLQMLSRHGSRYPTMGANVQALGDRIAAAASKSKLGAKHELAFLNDWKYQLGAEILVPKGRQELFDSGVLHAYMYSPLYNPNSKIIVRTTTQDRMLKSAENFLAGFFGLEWTQNATIEVIIEGPYYNNSLAGYLNCPNSNKIKSGSAAASIWIENYLQNATDRLAPLIDGYEWSLEDSYAAQTMCAYETVAYGFSRFCELFTYEEWIGFGYSIDLAFYGDNSFGSPAGRAVGIGYQQEVVARLKNHTLGYSGSQINVTLDNNTTTFPLNQSIYFDFSHDTNIISILTAFGLKQFYGLLDPSSYPGSHNFTASHLTPFGARLDIEIIRTPKPLAANRSGYAANGGETKYIHFVLNQRTIPLGWSFPECDASRVDGWCELGAFLRAQEDQPRLARYEQACFGKYPLNLSVLDGAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7H0</accession>
    <name>A0AAE0P7H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_57386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="172" mass="19901" checksum="47BDFCE51E67231D" modified="2024-05-29" version="1">MHTLLGIIYQRTFSYILISFNYIHWCTCGFIAYQAEDSKPGREAFVSTLRSLMLLVLRSVCASRAGGLRPRWYISTDSFLAKYAQDLKTLWPWVGKWLKSHDEEPWALLSFQPRERTTRTKTLSWGCVALLVTFKSSDSTEHILVSIMYYTSACINHHIPAQVVSHYFREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7I6</accession>
    <name>A0AAE0P7I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_56740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="264" mass="29234" checksum="0C4B34BCCC17A981" modified="2024-05-29" version="1">MEIRRAQELPGRIASELQLGQDAVVVPDQRMVANGQDHNSTSRTHEKARNVRLNIAMLIVGSTEDAGLFTSVAVWLRDKFGHRVRVATHPEFQSMVEACGLDFLNLGGKSCDGPGGKSFQSRGSFEAWKLALPGILQASWSACVGPRRDGRAFVADAVIANFPSFAHIHCAERLGVPLHILSVRPWTPTRLLAHPLAHIDTCEVGRGLANLLSYALVELMLWREIHDPINNFRREHLNLGPIDLLHGPGLLQRLTTPTTYFKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8E7</accession>
    <name>A0AAE0P8E7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_462420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8E7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="570" mass="62197" checksum="FE739211FC006141" modified="2024-05-29" version="1">MVIITTYTVSEVVSDSPSPNENGEPELLVVSSSTITTSMTSWYLPVSTATIATTRPWEPPSPLGPIPPGAEAAFFNLRTELDFLTASAIPVLLATLLAIPIEILVNTLSYMLPVRALGQPGGATAEDSVFLGRLEGSSLLTGPLVTWRFMQHFSDPLPLLNLLLSVSSILLVPLSSEVIRLEFLPMSRQRDDNSMCSFGLLLLPETCGIGLRKAGAPMRVAEGMLVLIAALVIGIGVILSRWQTGVAAEPWSIASMASLLQVSKDGQLGHVLRSIPPRADDHCDDRIFSSSPPQPPPPPPTPHDESTVRALAEAKGTLVREGTRFQLGSLYQGQTASTPDSDHQPDSCYGIIEMPPIATDDKLPIQPTTRNPPKPPKAATTQNLSRKRRRRPWYSIMSPSTMEQTIQVLALVLVTGLLILILYYENTINLNTTFEAFMDSQSFGVRILFTAFGTAVSRFWAYYYCLVFEPKLHHRLATNGPQPARKSILLTPPSSNVFAGLGLRYSLHNIDDILSLHIAIAALPSQVHAHPLLQHPLPQHRHLEESRDLHLDVSRYPGVYGSGTGRGSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8Y1</accession>
    <name>A0AAE0P8Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_65591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8Y1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041927345" evidence="1">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="27773" checksum="D2AA55F8C564E0F9" modified="2024-05-29" version="1">MDIFGTVVMAGTIVLNFLSACRGFGPDARRLEVNFAWDLAAITAIQDYFKKREEQGEDIGLPQDQRRLLQDTANYLDELVDDVHGSLRKLQTKGLAINVINHAMWIKRKGAISDMQKGLNEWTKRFDVRVLALPPELRAVIPTTTPGREGADASPPAVVRSHQRIKQFRECDATQRQQLAATILLADSADLERHVKLREKEIATLPLPYGGENLVFAARRLPDGVGPGHARYEGLLRDMGELAAQLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW25</accession>
    <name>A0AAE0TW25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_546090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW25"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="431"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="727" mass="80980" checksum="2A43B03C994811ED" modified="2024-05-29" version="1">MSTTQMFGYLANLFPTLGRKKKTETSRDSSLSLRAPGSSRGATHTEQAQKSTLTRSNAIHHSFRNTDYSDGPSSLELQTAAPEETLVVDSEWPAAIREAEGTVITRDEGIDSNSPKACAQHILSQLSQFKGLRSFIGRSLTPRGVLLLKILESQLPNSQLPPTQIYGQGEIPEDATQLDYALTPDQAMKLAISLDGAHNTMAIGSICVRVCSLCNVLRFFAARRLSLPPQVRLFTPFSTFSTSSLQPNPFNEFNSFIQGTTPCCSRLICDTCFLQGIVLGIKKDWWYNTDDSHWLVCPYPECRTTLALRYNVQLTNLLNLLRDSHAMHHIMQFERATRFRTTIRDFDPVLTAEALERAACLHAQLMAHGLMFDPFDLELFPQHPKMETMSLDSLDGRRTLTVPIFMGLFTRRPPSPEDTALTSGPSSGPDMTRDCIVCAETFPDVTDGSPEDEALWAAAISGFPGDWTWQVRSFPPPSELKTCAATHSLDICRDCLGRHLAAQIETRGRAGCDTLSCPIPDCGHVYSHSEIRILASAETFALYDKLRLVGHLSEVPNFRWCLRKGCGMGQIHEIVPDMGEEDARTNRQRNMILCDDCDFQMCFEHQVPWHKGYSCAEYDSHLGTGDPAIEATREWLRTHTKSCPGHRCGAPVEKKGGCFHMTCRACGFEFCWECLADWSAIHSLNEMTGAMTYNRLAHNPGCYFREDGAPLAMAVRGNTLVEAGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW73</accession>
    <name>A0AAE0TW73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW73"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="38736" checksum="6E1BAD7B680DD289" modified="2024-05-29" version="1">MSKPAVPKPRRNRLQKHPEVLPDHGESYSQLSFDCGMNWLRRPQGLRRRSSTSGSSRYRTPTPHPHPEPHATNTRERAVGRWEYDNYRDDPGYVGWTSAHKPGRAKAVVHSPRPQSRHHRDGAPASARTISPLTLPSAAIPVGSSTSQSTAASFPASQHYHRPRDDNDRHRAGSPSSTRANSCSSSSDEAPVLLPSSTVRDYYNPPPEPDDGARGRPRHPRPVNQSLLSWNVLYNNFLGGGGGEHSRSTSSASTSSSGISPTSSKRTAGTKATRRAQKEDEAGESSSAGAAGSSSSPNQTSLDSSPLLTPIGPRYNSVAGRREVVIVNQAGDLHPQPSAAKIEDDLGEEEMVVPIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ63</accession>
    <name>A0AAE0TZ63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_542665</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ63"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="351"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="692"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="820"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3384744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="955" mass="103861" checksum="05B27BCF6F7F0920" modified="2024-05-29" version="1">MSAPNDGYGQYPPQQYGEQGQYPDQAVQGYGNPSSPPPQPGAQPAVPDHGRKKKRAYAAGAFEVAAGGNAAVGGQLPGGGQFGAPQPAVPAYGGYPQQDAQPAAFAQPAAYGVPPQPYGGGQPGAAPVGYQPPEPYYPSAGAPAAAGVTPAAGVAGITSGLTSMHLGAGAQQPQQLPPQPRPGPLNQLYPTDLINQPFNVSELDLPPPPIILPPNSSVTPSPDANCAPKYVRSTLNAVPTTHSLLKKSKLPFALVIQPYAALHDLDDPVPIVQDQVISRCRRCRSYINPFVTFLDHGHRWRCNMCNLTNDVPQAFDWDAAAQKSVDRWQRHELNHAVVEFVAPQEYMVRPPQPLVYLFLFDVSYAAVSTGLLATSARTILDSLNRIPNADRRTRLGFIAVDSSLHYFAIPKDTDESGETSMLVVSDLDEPFLPVPQELLVPLTECRTSIENFLTKLPEMFLNNQNNGSCMGSALRAGHKLISPLGGKIVVLSASLPNVGYGKLEMREDKKLLGTSKENALLQTASSFYKSFAVECSKNQVSIDMFLFSSQYQDVASLSNLPRYTGGQTWFYPGWNAGRPEDAIKFASEFSDYLSSEIGLEAVLRVRATTGLRMSTFYGNFFNRSSDLCAFPAFPRDQCYVVEVAIDENLTKNIVCMQTAVLHTTCNGERRIRVMTLALPTTTNLADVYASADQCAITTYFSHKAVERALSNGLESARDLLQSKITELLQTFRKELGGGSMGGGLQFPANLRGLPALFLGLIKNVGLRKSAQIPSDLRSAALCQLSTLPLPLLMQYIYPHLYSLHDMPDNAGTPDPETSHIILPPPRNLVSLSLESYGFYLLDDGQTQFLWIGRDAVPQLLADVFGVADRTQLHVGKGSVPELDNDFNERVRAVIQKSRDYKSRGVGSIIVPHLYIVREDGEPSLKLWAQTLLVEDRADQGMSLAQWMSTLREKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U053</accession>
    <name>A0AAE0U053_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_473898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U053"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="338"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="470" mass="50363" checksum="336CC93C0DFF04E8" modified="2024-05-29" version="1">MSQGDQAPFLLFLCHPLSGHVTPILRIASGLRQRGWADIAFLSSAFFCARIEAAGLEFIGFSPDADADDTTLFDKSAPPPPVLSIIDSHHQTIARLPAQWECVKSALSMLHARDPARRVIIITEAFFYGVISLKRGALPPHGVPVPQTICVSILAPAIRSLDLPPSFGSPHPFDPSSQGRARNAALWKAWEEQAQPVTDLLNRKLLEAGATQGLGANEVFMSGANYTCHDIILQVGLREFEYARVDFPAGFKFIGVLPPPPSSTTTAIGRSDVVAALFAELTTNAELDEKDAGRCKVVVVAQGTVETDPSELIIPTLELLSSENVVTVAILGARGASLPSAWPVPPNATVVDYLSYDAVLPFADVWVHNGGYGAVMHGISHGVPMIVAGEGQDKLDNGKRVAWCGLGIDLACAKPEADKLATALKEVLAEKKYKEIAKRIQAAANKMDTVGLVEEEILKLAKSCFNQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U055</accession>
    <name>A0AAE0U055_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_450107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U055"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33681" checksum="23A2FAA0E567FAF0" modified="2024-05-29" version="1">MPFPSKNTVTTHQELPTAKGPSTSDEERHPFSDGSAITSEPNSDEEGGLSPSPSSWKDQIMQRRQHRRRGRRQMKWLLVGVLFVATNLLSGLAGAGVDRWRTNLTALCAGHTSQYCTVSHTPPVIKDVDIKYRWQNFNGSFMNEDVFRKARSPEVDAAWESMGVNYKKAIPPPPFISGMISYKEGIKSGLTDAHVQRSEKHGGGFFVNVEGLHHLHCLKLGKGAFSNSQYIVQLHALWYYEDETQSSSVAFPDFKTQHRCKNYNDIRDWAGKYQEPPAETLSDDYAKSPKKEHILAEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0K5</accession>
    <name>A0AAE0U0K5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_192686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0K5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="534" mass="56492" checksum="0B6E58B6ABBDD9F7" modified="2024-05-29" version="1">MSISSCVPATFGTPTILGTQILSLEANLVTNYSTPAPIPAVYRFTQPAIEVQNVTFCNVTVSYTHTGQDDELAVEGWLPVDWNGRFQAVGGGGWAAGRVPFTYAAMGGAIAEGFATVTTDAGLGNATGLESGPWALLSPGNVNLYNLQDFGSVSLNEQAIIGKSLIASYYGKGPTYSYWNGCSQGGRQGMMLAQRYPDAYDGIAAGAPGIYWTEIPPAAIWPQHFMNTEKAFPYACELEAITAGAVAACDGLDGVLDGIITEVDACLASFDPFQLVGSSVSNCSDVGGKTQDITVAAASVANASWHGSPQWFGYSPGADLTHSTADPGTPNTQPGPASTNCTTGTCVGVPNELWLQWLRVFSAKGDPSFNFTTLTRAEYDRLAHVGAQEYRSSIRTDDPDLSAFRAAGGKLVSFHGLSDNMIPWQGTRQYYDAVAARVPDVHGFYRHYEVPGLGHCSGGPSGQPDSLFAQLRAWVENGTAPAESPIKVTLQNGTVQNRVLCPYPQKARWQAAGWYCSSSVSSSAASSPKSGFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0T1</accession>
    <name>A0AAE0U0T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_140623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0T1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3386768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="39637" checksum="301C128EE7067905" modified="2024-05-29" version="1">MSGTDYKFEGWLGLDASAAEGNMKWDEFEPKPWEETDVDIKISHCGVCGSDLHTLRSGWGPTNYPCCVGHEIVGHVVRVGSEAEGDLKIGDRVGVGAQSDSCRGRKGACKACESGQENYCPKMHVGTYNGVYMNGGKSYGGYATYNRAPSRFVVKIPDAIPSSEAAPMLCGGVTTYTPLRYHGAGPGKTVGVIGLGGLGHFAVMWAKAMGSDKVVVVSRTSGKKDDATKMGADHFVATDEDPDWAKKNANTLDIIICTVSSSSMPLMEYLSLLRMDGTFVQVGAPDDGLPTIQPFPLIFKRLKITGSLIGSPSDIREMLQLAAGKKVKPWVTEVPMKDANKAIVDLEEGKPRYRYTLVNETDKTVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3E8</accession>
    <name>A0AAE0U3E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_427469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041924588" evidence="1">
        <location>
            <begin position="23"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="555" mass="58713" checksum="061A5C8546AE7152" modified="2024-05-29" version="1">MALFRPLLALVWAIASVQIASGKFRPRAAFPSLIDATVDDIKAALDSQLFTSVDLVNAYLRRIAEANPIVNAVTEVNPDALSIAAALDAERAQGKIRSDLHGVPILIKNNIATADAMNNTAGSLALLGALVPRDSFIASKLRAAGAIILGKSNLSQWANFRSSNSSNGWSAHGGQVSAAYIKNQDPSGSSSGSGVATSLGLVTVSLGTETDGSIISPSQRNNLVGVKPSVGLTSRDLVIPISEHQDTVGPMGRTVKDAAYVLQAIAGPDRNDNYTSAIPTNSIPQLPDYVGACTGGISALRGARLGVPTNAIELFQQFLNGSAQPEVDAFSVALDAMRVGTVGAVIVRDSNFTNLTEWASSTAEGTVLRADFRVNLASYLSKLTTNPNNVSSLSDIRRFTQLTPEEDFPSRDTVTWDEALDAETGFDNTDPRFWPALQEDLFLGGEGGLLGALERYRLDAVVLPSSFAPGFAAIVGAPVVTVPLGFYPPEAPVVMNTRGDLVDTGPNVPFGFSFLGRNFDEVKLIGLAYAFEQLTQVRGKVRPYLVPTKEVSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3J6</accession>
    <name>A0AAE0U3J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_101794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3J6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042178599" evidence="1">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="35"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="331" mass="36151" checksum="D1201C88660C22DA" modified="2024-05-29" version="1">MIPQRTTLGAAFLAALPFFVAPATAGPLASSKRGLVYVPNDKTRGDDSIWVQQPSDLTWYYNYKDVPSPVYENLPQSKFEFVPMLWGGLDNPTTNMTFYNKVAGLINDNGINISHVLTFNEPDGPSYYGGSDMNSQTAAEIWVSNIIPLQKLGVRVGLPACTGAPSGLTWLKDFLGHCSKLISTDKETKNCTYDFVPIHWYGNFDGLASHMGEYAAEFPNKTMWITEYNLANEELEPTQAFYNISAEYFDRLPWVERYSLFGSFRSSVSNVGANAAMLSAGGQLTDIGAWYLGRPGTGVNPKTGAALPSVTPQATLALLAALFATTSLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4G3</accession>
    <name>A0AAE0U4G3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4G3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24504" checksum="7520E8B51CEAF51E" modified="2024-05-29" version="1">MDSADQSPEVVRDQDLPEVLSHDHNQRAHDNEAFQRAHLEKLPLSTKRMILRLRRSTFWFLAILLAAVITVAAIDGSLWGSIATNNSKSFILHSSFILHSSFTPHSTFILRGSSFILHGDRACHSQVQRIEISGTTKFFLPSCHTDGGGGGLVTIFAYSLWDCMFACTNFHVHFPQSCTTMVLQPNMPKRRPNGGSCFLKNATTDAVLDPDNVAAVVVPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4V1</accession>
    <name>A0AAE0U4V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H63DRAFT_132255</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4V1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23148">
        <property type="entry name" value="RING-HC_ScRAD18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="22">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="422"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3391118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="514" mass="57103" checksum="A2F1B766DCB1AF56" modified="2024-05-29" version="1">MDAALHGEAFDVPDSTDWLDTPLKGLMPVEQAFRCHVCKDFYNSPMLTSCNHTFCSICIRRCLMSDGKCPLCRAADQESKLRGNWAMREAVDAFVQSRDVILKFARTQPTAEAAVPRSPKRKAAESDGTEYGGQENKRPRISTRSSAARGEQATAAIMRDEWEVPEDHDFGGNFEPDDGLVSCPICLLRMKPFKVDKHLDTSCPGSPQPQPQRQQQPQSSTSQSWSNPAFRPARSILRSPPTQGGKAPERLPGVVYSMLKDTALRKKMSDLGLSTSGTRQMLERRHQEWITIWNANCDLARPKRRSDLLHDLDIWEKTMGSRAPTSSRAAAVGAQIKDKDFDGAAWASKHNDSFKDLIANARRTKSKAEKKGQEQESTTRPAPNNTTTITNPATNQLTRPIIPTTTTYENYYDHDYYHSGEQSNQAAATTNSAPQSSNNSSNSSLPYMDPRLFKPDPYLSRGGGLDPPSRNPEDSPVNFPHPPPPVADGTTTDGRRQQPRRNGNRPSEPSPPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6H7</accession>
    <name>A0AAE0U6H7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_554249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6H7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="288"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3392751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110449" checksum="ACD50D932D68194A" modified="2024-05-29" version="1">MRRNRTPTPPASPYRALAHHHAHYSGAGAQAAPQQVVQDSVSSLIRSFNVATNPTRPMRPSPLTASTIRDMPLDLVDRIRSFPLFMSAPDDFLVAIGAHLRPQIHSAHDHILSEGDEAKAMYWLVRGVVAVTSRDGEAVYAELKPGAFFGEIGVLMDIPRTATIIARTKCLLVVLKKEDLQAELPKYPDMEKAIRQEAQERLTILKKKRQESGQATKLSDTNGSKLAREMAPGEVSTGEKGAITEGAVVKSKKRKSPSPGVIEDPAVGGSALGSGYVNVRKTLKELPLFSTLPPDVLHVIGLSAQPKSYSPFTDIVRQGSPGNEIFFIVRGEAEVIHEMQSPTNLKRLTRSSYSRPRLKQGQYFGEAVECLMIGGDALDELWKRCPPEIKLQVEETARKRYHSSDGDVEMTDADSNGTSDDEPSTPAKTAALPQVTFTTPSKPGSPTKDQAAETRQPSDPDPFLSVDMENLRNRRRNSLAPPTPQTDSSTIVSGVKTNTVESSPLKLFAPSLAASVPLDDSPLPSKRPRIVHRRSHTLDEMQKPLFSDDVLLSIFNHLDLLEMIRLRIVCRKWRRLLTESPNLCTHVDLGPINRKVTDWSLANILGPFIGTRPIEIDISNCFHITDEGFQALYKMCAKNVKIWKMRSVWDVSAGQILDMSEHAKGLEEVDWSNCRKVGDNLLARVVGWVVPEILPQRETKNVVISSSAARGRKGSQHQQRAGKPNGENATAPVPPPPGTIIGCPRLSRLNLSYCKHITDRSMQHLAAHACNRLQSLSLTRCTSITDAGFQSWAPYRFTELTHLCLADCTYLSDNSIVALVSAAKNLTHLDLSFCCALSDTATEVVALGLPILRELRLAFCGSAVSDASLGCIALHLNELRGLSVRGCVRVTGNGVENVLEGCGRLEWVDVSQCKNLGGWLIGGGVSRWGFDERATGLKDEGWKISSASKPLLTQGGKIGPGGVSGGVQRAASNIKALGPGPIMRPVIPPKGATNRRTRKPVRFVVEKGAGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7X9</accession>
    <name>A0AAE0U7X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_385374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7X9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="26753" checksum="9E012E3D394A290C" modified="2024-05-29" version="1">MASEDYTTIVLITGANGGIGFETAKKLGAEHSDYHIIVSGRRKDAVDEAVTRLQASGGSFEGILLDVTSDESIAQAAQTVQEKHGRLDVLVNNAGVAPSEGERPRQLLKDIFDINVFGVVQVTNTFLPLLEKSQVTKRIVVITSGFGSFGETLGKGRDECHWPIYSVFAAYSASKAALNMMIVHYAIRFEKDPTWKVNLCCPGFCATNLTGYPGGEDPANGAINACRLATLGPEGETTTFTNRHGPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U844</accession>
    <name>A0AAE0U844_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_35331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U844"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042231376" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12308" checksum="4A5471DF5A012F34" modified="2024-05-29" version="1">MRPVCRLTLVCLSSVCLLCRGYGYLSQPPCVPQHWIHRCGRSWVPFTGTQVAFWACLFHSKRSICPGPGGSRDLPVRLTTIALLAQQAWPLPIACCAGIQRRNIRFRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Q3</accession>
    <name>A0AAE0U8Q3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sds3-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_461420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Q3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000002">
        <property type="entry name" value="breast cancer metastasis-suppressor 1-like protein-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="693" mass="77325" checksum="A70A88EDC4234D91" modified="2024-05-29" version="1">MATGDTAPLLARSSPPSPLHARSPSNLSSPLSDVEDKDAEHGDADMDAMHALDFRRRGTPEQVARGDGHSDADSESDDESKLSEMDVNDSEAETERLYDTPPKSTESRDILNIVGDVGNRQFIDRRDRVFERSPSKLQQQLQATLDARDAASDNNYLSEGEEEDDDDVSMASRASSEHAPEPGVPNAQRSPYQHKKPPEVIPSTESTISETISQESLESRKRKRLSLAEQSESEQPLRKRTGSIAPPEVDFSADDTVVLDDERTSTNPQSGNHTAEEDNIEEPETAVQHKEVPTESIEEDTTEGGRSRKPKRNAAKKRKSKSPEKGSGQVTEDAQDSALEDMEGPAAEVPTPRIEDGNADDADEDVVAHKEEELERKKAAWEELTAIEKQFNSFRDRLYQERLDQLEQEEASLTAETPSHPEYLAMLQCLEERRQERIRVSTLELQFRMSVLNGRAVAERSQVMSQFYQSIRESREKVLEELGQEWYDIQQERRRFANTIPDYGIRFPTAKTQTVKSAVAYNKEVSILSGFAKHVGFPAAPPINGASDDQLESDLEAISRTREPVHMPTSIPPAVFHPEFTSGLPFGRDLGPAGEQFIEQTPWANPNHPSHHIQRQNSHQDTSIHTTYAGPSLGHRIHSHQPGNIFPPSNPPTMNGEPPLQMQKNHLPAHETIKASKFGPDHPMKRESIAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8S7</accession>
    <name>A0AAE0U8S7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_506593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="44"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="47613" checksum="6DD52959E7B2312E" modified="2024-05-29" version="1">MDISARFDEVPPLPEEQSSSVTTDINKRSDNEALFDVKVIPEKGRGLIARVDIPKGTRMLCEMPMFTVASIRDPGELERAIGTKLRSLSKEQQRQILSLHNNYPGRHALGGIVKTNALPCVDSGAQEGGIFGTAYLINHSCLSNAHNNWNPAAAHEKPDSNSMSSSGKRQHDTPGQRQTKEESKSEIQTLKDEILQLEQTALALEQKQMIEHVRYRVPHQHEYDFQMERRMADMKARCVSAFGPLSYLLRGWEKTPNTPEDLSIEALKKEVPLFQHVRALVTVTIWILVLGFGVRFKGCTRTFADGVITDVQTAFLRDFPEPLNRKAVITYVSACYRAYNASINVDNAFGTVAEKAEARAKVAESTLKHLRKLLKDTFEYFGFSIYGDTCQQRLREAIELGMENIRKMGESGAGYVLMDIDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JY83</accession>
    <name>A0AAE0JY83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_529899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JY83"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="18549" checksum="9B0BEE15E793B2F6" modified="2024-05-29" version="1">MILLSMLGAPGRESIRGFVFALELSWTPSRSSTSKLRKNEKMLMSGSSLLGGRSGTIVTEAITAITTFCPSPTTLTRGTMEYTATKATTLTIKDCSCTVTKLWPTGLSYYNKTLAGARTKPPGTSSSMLIVTASSGSSGGGSRDGSAPFISGGDQGAIVGNQALHWAVVGVGAALLLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYV6</accession>
    <name>A0AAE0JYV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_92163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="19240" checksum="7824D31892CDC937" modified="2024-05-29" version="1">MPSLMGLAALCIAMLAALTSCTVYFLLCMLPQLLAVFLHFQSLDLKLRILQPWAAAPNQDGATASQSLHADYVACAPVQSSIHALRSGDWAVAASSLLSTLFVLIPILAGRTFVAPTSPDGAVRMFSNVVASGVVLALLVLHFLVLLALLAWISPRKSFCAPHLPNTWLACSAAWRTGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0C3</accession>
    <name>A0AAE0K0C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_423772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0C3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="192"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3367688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="490" mass="53635" checksum="02A3799061713E0F" modified="2024-05-29" version="1">MTRSSTESPDDTPKRAVTSSSVFYPGILPVVPDASQLPEKGPSSNAATGATAASARALTSQAVAFYFRAPVKAFFRTRVDYLAYARALQEAQQAALHQGLLSHLNHLPAPSISQGTWSNIWIWMKSRAHGSTPGLLTSAIRHYGWRVVPDQVLPPLIANVGVGAVLYTSYLHILGRLHPESALASKRVYPPPEPVQAFTAGFLAGSIQSVIAAPLDAVQARYDLGTSAAGMTGNGNPVPGTNGHGRPQSMWAFGAAKLREIGVRGIFAGWGLSFLKDSMGSAVFFTTFEYLKAQGYYGFVTWYYGALNEDTIVLLSRRRPTAAADIKKTHSGPGMPTLIRPHYAIEPAFLLLAGMGASFAQQTVLHPLSHIQVEHWERLEALDAQARKFRSDARLRASSSPKSLTPKPTWRMLRAYCAAYQETWATCLAEANTAKLSMRRWLYRGFWWNTIRQVPSTSAGLIIFELVRRKYGMGGEPVRINKDGYDILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0N6</accession>
    <name>A0AAE0K0N6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_515324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0N6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3367462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="629" mass="70522" checksum="E08FB8E279B9668E" modified="2024-05-29" version="1">MTSEGQPDANDASEGETAQDHSSLKYSLLGPSLTKAGQDSVDQSKVSEIIYNASKGSKYFNREEARDKSLTAKIEQILTKKQRLEKLDLSQDLRAADNLIAQLESERDLTQHIIHMDCDAFYAAVELLDRPELKDLPFAVGGGVLTTCNYVARKFGCRSGMAGFVAKKLCPELVLLPLNFDKYNAKAAEVREILADYDARFESASIDEAFLNITEYCANHEDMDPADVVNQMRNEIHDKTHITVSAGIAANARLAKICSNLNKPNGQFVLPRERAAIMAFMHDLPPRKVNGVGRVLERELASIGIKTCGDIYTQRQYLRKLFGEKTYEFLIRCYLGLGRTNVQPAEEYERKSVGTESTFREMGGPLQSREKLRWTADELEKDMRRAQCKGRTLCLKIKLHTFEVLTRQVIAPKPLFLADDLYNCALPILAKLEQEIPDLKLRLMGLRCTHLVSTKKPDTRAFFGLRPLRAESGASTEQGSGPKMMLTNSEDEWERWPEEILEDHRPSADGSEPGPEALSPCEGSPFRRHGKEVLPNPRREQSAPVEEDWWDCPICGRPQAADERNFNGHIDLCLSRKAIRDTVQQDAVVHAPRASIGTTPETRKAKDTSKKRGRSVAAADPRQKKLCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1I0</accession>
    <name>A0AAE0K1I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_489887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1I0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="303" mass="33051" checksum="75820896D11D2537" modified="2024-05-29" version="1">MTIQNVTIVGANGNLGSIVLKALLTADPPFQRVTILRRASSRLSEPLHPSIRVIEVLTWTASTLTEPLTGEDAVIACFPLADVNAHFALADAAADAGVKRFIPADYGSVDARSPRARALVSLFDNKVRVREHLEQLAAASSSGFTWTSLVNGHFFDWGLTNGFLHFYPETQTAEILGDGTQKSSLSTLHRVAQAVVSVLQRPDETANRVLMVQSFCVSQLDVLSALERATGTQWKAEFRDTDAFIAEKKTLADAGDKEAIEDLVFALGVIEGNWEEEEDFAMELLGLKEDENLDRVVAGALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K289</accession>
    <name>A0AAE0K289_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_565028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K289"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="70"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="535"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="604" mass="66163" checksum="36CF05E7B78301B9" modified="2024-05-29" version="1">MARSLPPPTWKHGFRTPVVAGGSEGTTPPWADERYFIDENGKMAHNLVADAGPKPAAVTGNAFGVFQIRTGPFGLEVAMVLARQGVKFRFIDKAEASCLSGRSNGLHPCAIEYLQSWGLGTEFAAEGPQHQSSVLYRSGIKLFHGGSMTCDSRHKVLVERCVTVDRFQVEDGEGKEYPVLVTLKDLRTGKSEDVRSKYIVGGDGAASKLREMARIPLNGLATDCFWAIVDCEFKTDSLHIRTLSMIVSPEHGGTILIPREDGHTRFYIQMTGEKGAKLAQSRKRKRDAENQSAVGDMQITDHGITPSEALEQLNKIMAPWAVEYATTLSWFAVWKINERVAHSLSSSNQRIHIGAHSAHVHSVLGAFGMNSSIYDAANLGWKLDMSAKGLAKPSVLLPTYDSERRLYANLVVRVSGAWLRFICNLNLPLAELRRSGEELETHDEDLPLLDGTAEADRRNSMFMLGVDGSTVSSAICPPLKEDSKEALPPPTSLLNGGVVREKILRFAEVDDLIEEASMEESLVATGPSLNVKDMLTLSSVVYDDRAPDDDAHCWYGINHARGAVVVVRPDLMVGMSVWPEDAREIGEYFDGFLVPTAGWKGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K396</accession>
    <name>A0AAE0K396_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_515235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K396"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042236397" evidence="1">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="289" mass="32420" checksum="45EF5A5BC3178136" modified="2024-05-29" version="1">MVRAVRAVQLAFAGSLLLGSAMADIPSLPNYRVVWADDFDGGPSVDKSAWDQVSRWHNQNGEIEHYTDSTDNAYLANGELSIVPIKSGDSWTSARIESWGNWKCPPGRALVVQAEISIPDFESRREETRGIWPAFWALGQNIRGGVPWPKSGEWDILESNNKLGRAQGTLHFAQPGGPDENGNYRDNSHFWQQTDFGAGYHTWALKIDRRNDDWWYQKLTWYIDGREFHSVTGSAINNYEQWTEIAHSPYFIILNVAVGGEFSGYPGPDTLSGEASALKARYVAVYEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5F2</accession>
    <name>A0AAE0K5F2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_421694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5F2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3369985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10789" checksum="9B9836CBB42B789F" modified="2024-05-29" version="1" fragment="single">MGELAMALKALGREKEAKAMLADCFEAQQRVLGPDHAHSLISMANLAGMLRDLGQDEECLEIMEECAAAMERVSGLDDPRTCNVWAVLKQWRIDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5S7</accession>
    <name>A0AAE0K5S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_564719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF41">
        <property type="entry name" value="ENDOGLUCANASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="61"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding X2" evidence="11">
        <location>
            <begin position="370"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="576" mass="62881" checksum="E46DA09D974B1922" modified="2024-05-29" version="1">MKIKTAASSALVAAQWANAGLTKRSCDCPDTKFTPITAQEWVAAANPGWNVGNTLDAVPNEGSWNNLPLQGSTLDTVKAAGYKSVRIPVTYTDHFVSSSPEWAINSTWLQRVSDVVDMATSRGLYVITNIHHDSWAWADVAKFNANQTQIQGQFYAAWLQIAKKLHCKPSMVALEPINEPTGSTEQDSDNLMKLNDQFLKALADSGGYNKQRVVTLSGTGMSIDKVQWFKRPQNITNPWAFQFHFYSPYDFVFGAWGKTIWGSDADKAAVVADLASIRGNFTDVPLIMGEFSASHLNCEAAARWKWYDHVVSTATSLNITTFLWDNGLDNLDRYIGKWRDPVSIEVSLNAARGVRNSLPDSTTDASATSQSSSAYIFNKVGSPVADRSVPFILNGNSFKSLAVEDAVLKDGTDFVISGSTVTFKESFLSSQGLSATASPGTKANVTVEFSAGAASQVELVQWDVPTLGSYSASAKAVSGGDFWIPVMWKGLHMVAAVKIATSDGAYLVDDWTQWLPTLQKGRGTFNSHWNFDHDHITITKNAIDAVIASGKNTTFTLEFYPRAEGNGNMIDYTFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K621</accession>
    <name>A0AAE0K621_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_440707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K621"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000083">
        <property type="entry name" value="DNA damage repair protein (Rad9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="713"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1013" mass="109516" checksum="B084F34CC3F7D981" modified="2024-05-29" version="1">MTRSASIRKAELKALNGENESQDSLQVIDIYMKKYGIGITSSSPVLGEATLPVATTSHLAPSNETPPDHELPDSFGQETREVKQTHQIRASSISAIQDREALADCDFDKDGDAATNAQAAKPSGSPPRKSRKMDSSQSPTQSNDGRSYDRYDNCRTSSPGHQSTTNEVPHAVKLTRSSPGEQPRTLDEDDTDNLLYNFDDPTPTAKTKSSIQDDSGFVDFGTRGRLRSLASDQQDSPGPQQFPETPAPPKNPFRHGRSQLLAPSQLFGGTQFSSAVKQASPTSSRPSPADFNNNSISPNVFISSPLKARGIHTSPIPDPTSSPQILPGTSSSQLNNEATSPVNTSSTKTAIIPDSSHCEPQRKKSGPQPMGTYEPMRKSQERRSTSGARSDSPDGEEDDSIPRRMKVKSRKEAALDRLKAISFARTLKSDDIEVPSTSKGKSRSVADDYLAQCHEEPPGEAESDPLDTVADSQEHRVQTVQHQPSQGQESTQSDLEEDQVPDADPTPRAALDVPTAPRSPTTEPPGRYVPDMATGGDAIPETSPAERRLDLDAGSLPPLENPLLKAKSTPDFQSSPPAFSTRSKRGKTVPGSRVPRSSSTLSKLVSTPSLTSSTTPATEDSVAPMSVASTDIISNSSPARAKSTRRSAPDKLPKLKTGSVENLRHSARLGRRLSESPDELFAATPTFEQSLRASRNSTSKLSRSIIKNAQTQRGTKLFEGMAFAISFQSKRPGEKDDHYNSRMDSAATIERKIKQAGGRILEIGFDELFEALPVRTASANGHADVTPLEAEPEIGLTSAGKSTGFTALIADGHSRKVKYIQALALGLPCIACRWITSCLDRNELLDWTPYLLCAGQSTFLGDAIRSRNLTPYDASTAKLADVIDRRTKFLEGGKILLVMKKSVEGKKMAYVFLARVLGASLSRVYNIDEAKQEMKAAEDSGHPFDWVYVDGKSDQGRLFAPSVPSAADGKKRKRASTASVAEPPSKRVRTLSDELVIQSLILGRLIEEGEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6F6</accession>
    <name>A0AAE0K6F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_421948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6F6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3370175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="239" mass="25845" checksum="DA775C027E1799D6" modified="2024-05-29" version="1">MADRFPSLDDFDSGAQTEIKDASGSPSASNFLEREKAILGDDANQFATVEDADFDDDDDLLGGGIGATGGDSTFESQFPDITSHNESVAPGGTITGPSVSYNSGYGAFTEEEQEPEVIKNWREKRDAQNAKRAEQFAVQRAETVKEAQQNIDDFYENYNNKKEKAVAQTRKEAEQFLANREDTTSGGTSWERISKIVDISGKGAKGGAAGSGKERFRELLTSLRKDEKAPGAGTDAEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6Q5</accession>
    <name>A0AAE0K6Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="442" mass="48871" checksum="DB00C218AA866873" modified="2024-05-29" version="1">MSGSSYPHQRAEENHSSLKFSLPDLCTLIQNAMLNKTENYINPHNRCGLTLLLCCFKPLKASFDKIQLLQASLKQHLPAPDRDVQSTILSLLRQLKADFKALDRHGNSVIDLAFAALDFYLLGRLNSLQLQFSIFGSTWPPVIDMSSSWSVYKSMRPMISNQELGSQAGAAAWNDTTEHQLAHSLFKGNPVIPFSSVQAAVVKQDKVDYSCSALLRILLEKSPPGAPRNRFPPPRHLVARYFVEALSISVPADAENGNHPLKDLLKAGADPDTRLDDVCIRRSGGGGPTRIRMIEHYLVEDNVYTLDFEEEHRAFWTTQPWRVKRWDEPPPCGHVRPLNYYTDRYDVVVGEEEQNGESSGAGTSNDNSSGGDDDGSDENQRGGEDGEGSVNDNGGTSVDGGSNNADASNEHRDHSHDGSDEHHDDPDYLRDGSDDDEPDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6T6</accession>
    <name>A0AAE0K6T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_317889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="497"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1507" mass="169081" checksum="6F11425E1A04A363" modified="2024-05-29" version="1">MISNQRPNGLQAYILGTLDDSYSDIISRVFGIIFLATPHRGSRYARTLNSILSASIITKAKIYVAELEAMSPTLQDINEQFRLVCKSLHLISFYESLKTQIGTSKVLVVGRDSGVLGYPSEISSPMNADHHNVCKFKSRDDPNYVTLRDVIRDCVMKCSNSLSEDERAVIETPKIDQSAEADKFEVLQTLTAILGVEEVLSLTKYQELEGTCQWIQTRDFYDTWLQPSPDAMLRVIWLTGLPGIGKSTLTQALVNNLKVDDDSEEIQPGCQYHFFTFSDMTKQTVAYALRCIAFQLALEHDGFCRQLCEVYKKTKETFEEQEAEVVWTRIFVGIIFKMDFGKPLYWIFDGLDESDNALSLVNFIFKAKPKSPIRIFLTSRPTSILINFAQSRREFLTHVPLTAEDTRDDVKLFIRTTLDDTVPISEGMRDSIAEQMFTNASGSFVWVKLALKTLERAWHTEEDIQRALSNMPQGMQALFDRMARTIVAMKQSSPRNFALASRILAWATCSAEPLTIGQLAHALEPEFTKFQNLEATIVDLCGHFITTVGNTVVPIHETAKSFLLGNHQAKKEIPQTWTPLLNGPACHEHLAAACLAYLSSEKWVHVLMRMQDDEGKATQATRNIISENRTTLLLSEHPFLPYAVSHWAYHIRHTTPCAESSLLSLLQDFFDRHVLSWIHACAILRDLRIVTRAARYINFFAQKCNSHSSLNPTATVSRDQYSFFSLWTVDLIRIVGRFGRHLAEKPTCVYKMLPPMCPRSSMVFKTYASGNPGARGGNKLSFHGIMSDRWDDCLARLPIGEERTIYRVLSTVTYLICLVAVGGEIIVCYSETCEEARRMTHGEYVAHMAVNKSGSMLATAGIETLRVWEISSGEQMYQFDRSEDSLVMSIVFGTTDEELIVGYDDFRVTSYGLQKTVVLSEVVVEEDDGEDYQSCPRAMVFSPDVTKLAIAISGRPMLIWDMEIAALGKQRPIKCVRASDMTKHPDGAWNQVDSIIWHPDGLSVFVLYQDTTIVRFFLDDDDEAVESTETLAREMIISHGGKFLLTSDNAGTLSLWLLPGFHLVYRLSSPEEELVRDLAFSPDSQRFYDIRGAICNIWEPEVLLCTNDDDDSEDIPASDKNERSFSDPVLTTNTSFRSQITTVARGPGDRYCVCGKDDGSIAIFDASNGSKLRKAYSHANGSSVIALAWSPDGKYIASADDNGRILVKRLESKDEDGKWAVFPCLNFRDEEPVQQIIFHPSEKLMLIAFPESDRVWNLKAKTELWRRDRVGKDLWLQQQLWINHPLRKNLLMCMRPDKTFTVLSWFPDKGKAPSAEPVESTSSHALTEASSEYASSNSLRPAAVMLASPYVRRFSQSDSGRFVVAEVLSGVSAQYTKLGNSKGLRLDAMHSEAIQLATGAAGPSIKLVSTLDEEVCDLVRLFLGCYKEHIVFLNHEYWVCTFPFEQAVGRGGGGDGTQAAGIKRQFFLPRDCISPSSLPLVTLAAEVGSVLFPRNGELAVVRNGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9D1</accession>
    <name>A0AAE0K9D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_496864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9D1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="22742" checksum="516934BDD6D34FA9" modified="2024-05-29" version="1">MCNGNTKVLSTEPLSEAVWTKLVKTTYKDPKGVTRTWEFAERRTRPKGSDIDGVGIVAILEKETGPEIVLQKQFRPPLDKIVIEIPAGLVDEGETAEEAAIRELKEETGYVAQVLESSPIMWNDPGFCNTNLKMVHVSVDMTLPENQDLKPELEENEFIEVFHVRLADLWEECIRLDAEGYAIDARIANIAEGIEIAKKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA76</accession>
    <name>A0AAE0KA76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA76"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="313" mass="34760" checksum="7A5FD2A217ACC075" modified="2024-05-29" version="1">MSPATRTKRRERGSPKRKLNTARAQWGFRLHEKVDELFEVFTDKNNYRPLPDKPDIDRGLLLAVGYAKLDPLGSAVGYLFREDLRPALDNDEPQEKMRELLEHPTPPTSTIVAAKTSARGFPEKEPKFRKQNCVKGVAEKVAAPLPPPLAGSRLHPRLPAATGRGHREGVRSAGQRHCLVARRHQGAGWWRWPPGADKAAAEEKVKEEAHLKEEERVAAEKKAADEAKAAEEVKAAVPNESYETQLTTGSKRANLGRTLAASAFTLLRRYMTMGFAALQPFEEISNAWPPAVTDGRSRRTCKPEGRVEGPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEF9</accession>
    <name>A0AAE0KEF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetoacetyl-coenzyme A synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_274779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="108"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="573"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="74849" checksum="747D4C21C2F2A435" modified="2024-05-29" version="1">MTVTNELWRHGSPKSTQMWKFLHHVNTKYQLSLSDYPSLYKWSVENVAPFWEEVWHFAGIKASKPFDQVLPGSATMFPRPDFFAGARLNFAENLLFPPNTELDESATAVITVTENADHLTETSWAELREQVRQCSSALRAAGIGENGVVAGFVANHVQALVALLSAATVGAIWTGISPDNGVSAVLDRLVQIRPQVLFADNATLYNGKEWSSSSKTLEIVEKLQKHGLEQVVVIKSIKSIDSGLDLLREKGVKAEEYASWLQSSPNEPLVFKQLPPSHSLYVLYSSGTTGLPKAIVHTAAGTLLQHKKEHFIHCSLTSSSRLFYYTTTSWMMHHWSVSALAVGASLVLYSGSPFQPHSYMSIPRLLSSLRVTHFGTSAAYLIALESNNIRPAADPSLDLSALEAIYSTAAPLPPSTFAFVYEAFPARINLASITGGTDIISLFGAPCPLLPVRAGEVQCAGLGMAINVVDSASSMENPSPVSPPDAPGDLVCTEPFPSQPLTFFGPGGEDKYRSAYFERFGPNIWHHGDFVRMDPSTGGLVMLGRSDGVLKPAGVRFGSAEIYNVLTRFFAADVEDAVCVGRRRETDRDETVCLFVVIAQGKVFDEILRLKIKEIIKRELSPRHVPGVIEEARSGIPKTGNGKKIEVAVKQILSGMQVKTNASVANPEALDWFRDWASKMTQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEK7</accession>
    <name>A0AAE0KEK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_419762</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 20" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="19">
        <location>
            <begin position="99"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="18">
        <location>
            <begin position="100"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3375249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="38104" checksum="F7EEDF27817297F1" modified="2024-05-29" version="1">MSKSTLAVIAAVSAATGAAVTAAMYSLRSSDKKTTEIITTSTKTLIKPPVGAAAPVSASQVFSSTRTAVPAAAAALNAPVNPAGLFEYGFPGPVSDIASRQALISSFDRRLRNPQWVVEHITPASLAARDGDRKNSAFREDDMVPDKFRAKLKDYFRSGYDRGHQVPAADCKWSQQAMDDTFYLTNMCPQVGEGFNRDYWAHFEDFCRRLTNTYPSVRIVTGPLYLPRRDPQDNKFYVRYEVIGNPPNVAVPTHFYKVIFAEDAKSAAGGPVAIGAFVLPNAPIPNEKPITDFEVPVEAVERASGLEFATKLPVQRRKRLCADTTCSLVIKEYADRQKAFAKGGGSRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KES8</accession>
    <name>A0AAE0KES8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_277071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KES8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="295" mass="31963" checksum="1A8580119D62809C" modified="2024-05-29" version="1">MCDNHPGDVRAGTSESWPTSSPGQDDPTTDDRQFTHKCSGYALINDKSAASLPALYWHHIMHKEPAYSRNLPSICPMAGCWPPLVLNTMYDGGDKLHWALHSLHLPVCIRTACPGTTCLSERCHSVPGPQMSPSPGTPRPLTLKIDTPPAPQVGGGELCAAQSWPPAGDKALPCSWSIPCLPLTYTHTHSLCAMCARPLESGQHGGLLLVLHVRKALTCLPDLTHVWCNCMQVNHPPHGPLERQGVDSQLSKQHRGLHTASVRIAASLAHLAVIWLWGSGMAAFKNQGWRCALCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEX1</accession>
    <name>A0AAE0KEX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_260530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="778" mass="84196" checksum="46CABF8FF058355F" modified="2024-05-29" version="1">MYLRPDTPRALAARDLSDWVPVFYKPPSGDEDDPEKDLQNWSSLIGIITAICGNVLIALALNVQRYAHIRLHRERARVRERARQAMKNAAKSQATAAGYGSASTSNRSNGSLSTPNGGPAHAHDYTDDDYAHGPSEMDPLAQSFRSGDSRWSECSTDDDDETKVTSTYLKDPYWWLGQVLITVGEMGNFLAYGFAPASIVSPLGVVALVSNCVIAPLFFKEIFRPRDFWGVIIAVAGAVTVVLSAKQEETKLGPHEVWDAITSMEFEIYMGISVVLITVLMWLSPRYGNRTILIDLGLVGLFGGYTALATKGVSSMLSSTLLGAFTTPVTYVLLFVLLSTAIMQVRYVNKALQRFDSTQVIPIQFVLFTLCVIIGSAVLYRDFERTSSEQALKFVGGCLLTFFGVFLITSGRPRHDEDEDTLSDAEGIEETIGLSEQGHPVPQSASRHSSRRDSGSERSRRSSRVSFKEGAVNKPLAALSGTGFPSSRVPPTSSSAMGPTLLEEDNEDSPFLVNPWKENFGDASGQQNHPGLGQHTVSSESVVSVVSSAAVSDGEYQPQSSSTATPLNQPQQIPHVANVDRPATPRAPPPAPLLSTSRPHSHHFGGPMISPSPFSSTLSAVVTDKLLAHIDSSPTLLRKVASRRSRPSLRNSLFVPQDEFDSDSENEQQQSLVPRSAVERATTSRRDLYGLSGGEDADEEGGDAEAALEASRSFRGRARSLSHTLGGLFGVHVKRERARRDTGPPTPSSGGGGGGGNETRLLFESRRNNAERSTDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFE8</accession>
    <name>A0AAE0KFE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_260414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFE8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="24019" checksum="A24677911D4A0160" modified="2024-05-29" version="1">MSKITVAGVRQNVAELLEYSTETKKRNFLETVELQIGLKNYDPQRDKRFSGTVRLPTIPRPNMSICILGDQHDIDRAKHGGVDAMSSDDLKKLNKNKKLIKKLARKYDAFVASDTLIKQIPRLLGPGLSKAGKFPTPVSHADDLTGKLNEVKSTIKFQLKKVLCMGVAVGNVGMTQEALIGNIMLAINYLVSLLKKGWQNVGSLTIKATMSPPKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFF6</accession>
    <name>A0AAE0KFF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_261020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFF6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162179" evidence="5">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="63"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="46733" checksum="81B3CB8D63A6F5FF" modified="2024-05-29" version="1">MAYLSRLLVFLGLITPFVVGQALPLKTSSRWILDNNNQRVKLRCVNWAGHMETNVVEGLHRQSVDYIVDWIKQQGFNCVRLTYSIDHALDPGRKVSESFTNSAAAAGVPLDSMVNLYNQVVEKNPWIASATTRDVFGVVVDKLWAQGIMTILDNHVSKASWCCDLTDGNGWWDAAFGYNQWNSRYFNTNNWLAGLQAMASWAQSHPGVVAMSLRNEIRAFLLQDLNGRKDWYNYIKQAGDLVHQTHPGVLIVIGGAQSSTDLTHIRKKMLDTSGWQDKHVWEMHAYSFTVNFPDPFSNCDIVKAQYGLYSGFVLEQGKAYTAPLILSEFGVGMSGGPNNGLVDKDSRYLTCLVDYMQNNDAEWAVWAIQGSYYIRQGNVNVDEGWGLMDYEWKGWRNQQFPGMLGNMWKATQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFJ4</accession>
    <name>A0AAE0KFJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_482448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFJ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="224" mass="24529" checksum="E36A0C197B8BB2FC" modified="2024-05-29" version="1">MHGWSYLPAQVSIPPNLAHFIPRVGNRKERNCQPQRDRSSGPGRWDGNVSQRRFALTAGSSVPVSEAKYPPLTLNHDSREGALDAAAVDNKPILARSQCGVTIYTCVTLGRFSSYHWSSVSCTIAPKIQVEASLLLAPPTFPRGSVGSGIGSLLEAPLPSPRRPLYPCSVIQATYFSSWQGFLRCLPRCRDPSINLKAQPEVSYVVYATFPLFACVHPRPVSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFK6</accession>
    <name>A0AAE0KFK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_273476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000593">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="684" mass="74928" checksum="7A09B6FD1738ED03" modified="2024-05-29" version="1">MTSSLAGLPDRARPAGDKAQPQTPTKASRKEQAKRAGSASRDSSNGLPNRHNVDSDDINEQSPLLSPSSNDEEEHGFLDGPTTGTVDGHQTTKSIWYLILLTISIGGLQIAWSVEMSNGSPYLLSLGLSKALMALVWIAGPLSGTLVQPYVGMLSDNCRIRWGKRKPFMLGGAVATIASLMFLAWTREIVGGFLGIFGAAPESDGVKFCIIVTAVLWVYILDFAINTVQAAIRAFIVDCAPTHQQEVANAMASRFVGVGNIIGYLAGYVNLTHTFWWLGDSQFKELCAIASIALGATVLLTCLLIRERDPRSEGPPAKDQAGVLAFFRKIFTSIKRLPPQTKKVCQVQFCAWIGYFPMLFYTSSYIGEIYAEPYLEENPNMTPDELDKLYERATREGTFALLIFAITSLATNVFLPFFIAPTYDTQMGSPAESPAGETPSILKNYEDEQSWLDYLVIPGFTLRRAWMFSQLLFTGSMLCTVFVRTVTAATVLIGLVGITWALTLWAPWAIISAEISRREETRRAQEQQTPSSSREAITSLDGYSSDENRGDRDMSGDDEEGSDQAGVILGIHNMAIAAPQIIATVVSSIIFRIFQKPRGTPGDHSMAIVMALGGITVLLSAFFIHRIRDDPDSPKDIMSAIEDGETPTRPSTSHSRTRSHEQLPRASLERATLVRNQSFGGMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJP7</accession>
    <name>A0AAE0KJP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_561663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="448" mass="49016" checksum="68C33F36A682EA0F" modified="2024-05-29" version="1">MPLETIHESNPESPVMLNIMLDPAPKPLRKPSQSPRGGFENMPLGIPLSSALEGPQRSSSLQLPAAKKSGHRVRDWVKRSGSSRTARTANDARLSPSSLQSLGIIHLGGYRVAAADVEELPMALAPTDLAPTKKPQRSRSSSMDSRVTQWIDLYPDSMDMYAREQQQQQQKQKYQPQKPQRHQQQQQQIHKKQLPTTRLHHRPSKSEDLRPAPLRVPSTSSTRSEPATASDLSRNNSKWKPLPGVPGQSSSTSPTEPASSNPKPPFHKIEVMTTPATASNSPTLTREKSGTTTPSHPVPVVAPYNTPPLTPDSIKGGGGQVSTAAAAAVLPPPRLTTPTSTALERQHGTPSPLINTPPMLRHTRQERVWLHENYRGEAPFLKAWGLDIKKVEDREEGLEILRDLIRSENEMEDPEEGGDCGNILRRHGEGGDNKEGGGNGSAVDDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKU3</accession>
    <name>A0AAE0KKU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_224634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="705" mass="80375" checksum="988DAF7ABC383E47" modified="2024-05-29" version="1">MSLDDTDREPREVKNHLLFEIATEVAHRVGGIYSVIKSKAPVTTAEYGERYTLIGPLNHQSAAVEVEEMEPTMPGLAETIQAMRDRGIGILYGRWLIEGAPRVLLFDTKTAYGYLNEWKADLWNVAAVPSPDNDEETNEAIVFGYLVAWFLGEFVCHEKKKAVIAHFHEWLAGVALPLTKKRRIDVTTIFTTHATLLGRYLCAGSVDFYNNLQFFDVDAEAGKRGIYHRYCIERAAAHSCDVFTTVSHITAYESEHLLKRKPDGVLPNGLNVTKFQAMHEFQNLHQQSKEKIHDFVRGHFYGHYDFEPENTLYFFTAGRYEYRNKGADMFIESLARLNHRLKSSGSKTTVVAFIIMPAQTSSLTVEALKGQAVIKSLRDTVDIIESGIGRRIFERSLKWHDGDPLPDEKELITSQDRVLLRRRLFAMKRHGLPPIVTHNMVNDHEDPILNQIRRVQLFNHPSDRVKIVFHPEFLNSANPVLPLDYDDFVRGTHLGVFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRSKGVDDSINQLTSHMFDFAQKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPTSFSGDEEEDFIPGVEQKISRPFSVPGSPRDRTGMMTPGDFASLQEGREGLSTEDYVAWKLPEEEDPDEYPFPLTLRTKRTGPGSPLDGVQLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLP9</accession>
    <name>A0AAE0KLP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_247019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLP9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21845" checksum="76F1BAECD67C37DC" modified="2024-05-29" version="1">MVATSFSVLDANIRSSAEAATEFVDWYYPALNSGKSVVSGYINNNVRYKEAGHAPADICVNGIVVPTPDEWDSMLEKQRYTAITSKNTVHYIVESYDVHVINPDYRFAAPADLLPPTSGLESQRARENKRLEGVRIVMMLTVSGTVHFGTDAKDPVLKQHFNDVFILVPNWDVLSRAGSRATRRYLISSHTYRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0N9</accession>
    <name>A0AAE0N0N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_456233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0N9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="31575" checksum="8A7CF6D0678CD30E" modified="2024-05-29" version="1">MSDEINFPSGFTIKDLVAYGNTGLVLLDTSTGTVVKASHDGERSAAMAVEQQIYERFVQRGGHKGILIYHGTFESGIRLEYASHGNIRSYLENHPADELRRIRWAVQVAQALDFAHQCGVIHGDINGFNVLLDRHLDAKLADFAGSSLDGSPLLIGVTASHEYPGPLLCTEADIFALGSTLYELMNGSRPQAGLSDTAIEQRYKRGEFAETESLGNVGSIITKCWQGEYKECRQVVHDLEAARQSALTSSSHSTRPAKSTSAYTILAVATVVVVVVSALVKLRLSRAHQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1W4</accession>
    <name>A0AAE0N1W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_504596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1W4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="804"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="843"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3367826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="912" mass="98917" checksum="F8CBEE1659308C96" modified="2024-05-29" version="1">MASAGRQVEARSLSAINSLAANPPQYPHHPQPRESLTLYISRVPGTRDIILSTIKPHKKNVTAADVANSLYYLHYDSAFHEQLAAPRRLDDVNPSRSSGESGRSPIARKPLPASAKVSSRPTSTSDGAALAASSPTAVDGQGAGRYAPDNATRDMPPGPPAAAAPVGGYRANPMFQPRQGSKSPEPPVLPPRPQNKPPPSPSARKPLGPRPTNAMETPDRTLPAPPGYTLYDRPASPTTYIGGRPPSYVAEPTRIVSPSYGMPEPDRSPLPDRRERSASASASFVPFALTIIRRDPTSGSQWNIGRISSFQTNIPTPDMAAPDLNPEDMGSLPRAYKIDIHLETSGYAKYRGMPTLASIEANHLTAGHSFTQSGRTNNAAAAPRSAAASPVVIEEGFSRQVMMAYTKSWTSNIKSKFRRRPASWGGGQGDAPPEDLVPPKSFHTRHGSSSTTGSTDSVAWAEGRDMPNIKGGDTDSREGGGDPLAVITQPGPGLRPKGFVFMSPWDGKCEFRTSNTGRSLKCRHILDKNAKLDPREVAQSLRDAQTLGRSRGDELASALFGAKPVSELRFNLPDGDAHKAATAGTKGGSRWDPHHLHGQFNKLLHLEPRSSDEEMDYDAPMDLSLGQENAGGGNRGRRAKMGKLIIHDEGLNMLDLSCDDDRLPKMLLSTSTAAARQLQLAAVSARTTSPSATAAAAAAILLRRNTSPSATAAAQQWAMTMITRRGYATPSGPPPKGFRLPPPKNWDEEVQKTSDKVGRYFLLTEMARGMYLLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAVIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2B4</accession>
    <name>A0AAE0N2B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_455091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="131" mass="15176" checksum="9EDFBFA412FF1163" modified="2024-05-29" version="1">MAAMLGIHWREFDRVHNSYYAEGNGIVLRGTQLDNFEIVFSINMTGKQSFTSNRTEGSKLAHVFPVAFEVLGMMCESLYISGSWFRTLPNPTMFTWPKYSFSIHRLLATFLDSVYDQMALLEGDWWHHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2X5</accession>
    <name>A0AAE0N2X5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_71688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2X5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034962" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="26395" checksum="36C73A52F21AB3FB" modified="2024-05-29" version="1">MGNHDRSKLLQWACLLFVASTASATSQGLSLSDFEVITSSLVPISCILAYNRPVTGCSTGDFGFGRKCSAECVRGLNRAQSNLESACDGTSVPAASILGQVLQGNLVDLLCPGSSPVTTTSSAPTTAAKTSTRSVLTSQTTVRPTTSTTQSSTSATTTAIESDIPTFIPSSSPTPDTLTPTTFVPSSQPSPTSIMQVPSTSANSNSSPGPAEAPIGNGGGGSPFDVLASNDGSRRAASKGKWFQASSVAAILGLWLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3E4</accession>
    <name>A0AAE0N3E4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_80177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3E4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041773878" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="70"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="627" mass="65846" checksum="2BE8FBB0FF034393" modified="2024-05-29" version="1">MAILKHLAVALALASTALAAPATQGLETRQEEAESGDIAASFVSELIQNATAIDTEAQKAKRALCNAPQSLVVNAGYAKYRGSYNSATGLNTWKGVRYAEAPTGNLRWQPPRVPGPKPFAPITDATSFAATCPQTVPAVPGAPFIPGDEDCLFLNVYAPANAQKLPVLVWIHGGGYGYGDGRQDMTEIINANNKGFVVVSIQYRLGAFGFLSSQEVRTKGAVNAGILDQALALQWVKSYICQFGGDPQSVTISGESAGGSSVMYHDLAVNGGLGSLLFDQSIAASPYLPFQYNFNAAVPTSKYYAFSQAVGCPSSGDVFDCLVGTDTTVLQQANFAITQQSEYGYWAFYPVTDNVYITDRATKQLTAKKVNGKKLLVGSNANEGPLFVPPNIVTEADLIGWLHKEFPNLSTAQINTILAANPNSAETSAGPHFETNGVSGATAVTVSGDANGQLQRGNNILAEATFVCPSHWMAAAYTQPGKSAWQYQYSVPFAFHGSDVAAYFGPAGPNLSGDFTLAFRKIWGNFITTGNPSISNAIANGAAAANPNAPNGASAWPAWNEASPKLLNLNSTGGTPYQFATQWGTSVTQFASPGQQNAIAVAAADSWEGGRGARCAVYKALAPSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4Y0</accession>
    <name>A0AAE0N4Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_486950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4Y0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="149" mass="16541" checksum="F4947B5FAA0AC647" modified="2024-05-29" version="1">MYSQAAPAQPASPACCVCVAPARVRTRPGTTWRAPKGRTPPLRITPFCLQAQQARQARAPSSVPDPLSTVGLRFADPFRTEDPSTPFRFVSFCDCTAKTHDHHLLLMLIPIGRITGWLTVRCYLPSLRPWIARVLSCLLNYPGCNLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6J5</accession>
    <name>A0AAE0N6J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_302178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6J5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041923253" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13127" checksum="61373D7EC8709A1D" modified="2024-05-29" version="1">MHLCLLCILSLQQSQLCRTSPITISETGGKCRTDNVSAGPSPRLPPRHFAWSAPQWSGLEEFQWDHTSTTNTDYRSLPNLPRGEVQWSLHGAWLTIFCIYGGGLGQSFTSSKTRNNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6V9</accession>
    <name>A0AAE0N6V9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_527307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6V9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="643"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="825"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123389" checksum="D8CC635A3B250EF9" modified="2024-05-29" version="1">MGNVGSTPEEGASLYLRDQNRLSISSVAIISPRKRMTINIVPNAYPATRVSASRSLGDHAPIEFVQDTEPASPNSPPGFLLKLPNDDELVFTFTFIIRQAHPLVQGASGGQESATSTDTQINGLTFVYASTPREVENLVTREFHADPNLHKNSNVELVGLYSTEGSPSVTFEWTWRWKPPKNSEDKGGGWRNSCSFVEYDQRAHRLHTLASFSFFVANTSPFQNPPLSPSPPLLLSAPPKARVASAQSLESRISTVPDQDEIIPPLQVPSDTGSGVIPTLPATKEPIKVDVSCPRPGEDMSVSDDGPLFRATMKALEQKTGNMRMQMKKLIKRAEQVHAAQLETNDAFMGFIEALKEMSSTNANAVQPAIEHYFDKIAREILSYERQNTNNLQKIVIDPMNKLYQMDIKQAEAKKRDFEEESKDYYAYVSRYLGQRHDSIKAKQSDTKYQTKRKTFELKRFDYSSFMQDLSGGRKEQEILSHLTKFADAQARTFLATAQRVDDLLPQLEALSSEVKEADKEYQYQRREREEKRRLLEKTNLSYEPEPPATSSGPPPPVSVPNGTQSNSDTELGRADSTGSQLKTLASGNTGNLPSPGDLSKSPGGLTHHTSVGSPQQNAKFRGIRDLEERDPSLAVVSEKNSTQRKEGLLWALNRPGGHVDPRNLNKQAWHKFWIVLDQGKLSEYSNWKQRLDLHMDPIDLRLASVREARNAERRFCFEVITPQFKRVYQATSEEDMNSWINAINNALQSAVEGRGFKDKPTVSPGDLTFNGVDIGSVLTGKSHSQNHHNNHSHGHSASAVPARRITVGARPGTSRGSSFDENPDKLLQMLRENDQGNAWCADCGSNNKVDWVSLNLAIIVCIECSGIHRSLGTHISKVRSLTLDTTSFTPDIIELLLLVGNRVSNMVFEAKLDHALKPTPQATREQRLKFITAKYVDRAYVEPISPTLSRYSTPDETLVAAIKKNDIQQVLYALALKASPNVTDRSRGTHAVYLALAAADPAQPSPTPTPVPAPGAAPEKVIPFPVAELLVQNGAEIPSAPPAFPLSHAAQQYVEVKRGRRAAIEASGGGSYDGVGSLPPSNATLSPGDKFQKEREARLQKRVSAGGRLAKTPIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7A2</accession>
    <name>A0AAE0N7A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_302935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7A2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="342" mass="36454" checksum="C5B1AA1D2E68753A" modified="2024-05-29" version="1">MAAVDTPLSHHFAVSADGTKLSYYTVGSGPAALVLHGSMSYALTHKELALALSPYYTVHIASRRGRGLSGRYSSSVTDVEVLLPTPNTTANDDNSATLQVGDKTYPRVYRPEFTAAVLATESADLTALLSATGAEMLITVSSGALIVLHSLLQARAEISCIKKIIVFEPPIFFTDRPSAADLTLLRRFEEQHAEGDVPAAMVSAMRLVQLGPGWIPTWIMKALVGVMIRAQDKKQQSEDGVTSMRGLGEMLRYDFSIAEGMIAPAERLGVVVAAEKGVEIMLLSGGKSPMYMQQGMAALAEVLPRAKSVVIPGVGHEVLCGKDMRGQPGKAVPVIRELFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N989</accession>
    <name>A0AAE0N989_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_280951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N989"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="334" mass="36920" checksum="1A2294EE0801AA24" modified="2024-05-29" version="1">MEKAAVQADGLLIPLIDFSKFENGDDGQKLETAKAILNGFQTAGFIYLKNIPITAETRAHVFGTSAKFFRLPLDTKLSHGWTTPQANRGYSAPGREKVTQLTDINEVEKVRTSAPDIKESFEIGRDDEPGHPNQWPAEHGELVGFKSTMTDFFDQCKALHVEVMRAIAVGMGLAPGFFDGFVDVGDNTLRLLHYPEVKKEVFQINPGQVRAGEHSDYGSITLLFQDARGGLQVKSPSGEFVDATPIEGTCVVNAGDLLARWSNDTIKSTIHRVVEPPHTDEEVHPPRYSIAYFCNPNFKSHIDALPGTYASEDEKKYEGINSGDYLVQRLTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBZ7</accession>
    <name>A0AAE0NBZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_525380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBZ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="515" mass="57230" checksum="0097B9BE638106C4" modified="2024-05-29" version="1">MENVPAETFTRAEVAKHNTEDSVRFIIDSVVYDVSEFLDAHPGGEAVLRQVAGQDATSAFYNLHRHEVLIKYADLAVGTIKGEKQTIVVPKLGELSTVPYAEPLWLTPAFKSPYFNASHRKLQRAMREFTDTHILPEALEKERTGEYVSQDLIDKMSKAGVLHMRMGPGKHLHGVNLLDGAVDGKEFDYFHDMIVSQEQVRVACRGFQDGNMAGMVIGLTCILNFCKDLAMKKRISDEVFSGQKKICLAITEAFAGSDVAGLRTTAKKTPDGKHYIVNGTKKWITNGVFSDYFVTGVNTGKGLSVLLIPRGEGVETKPIKTSYSPAAGTTFITFDNVKVPVENLLGEEHKGIYVILSNFNHERWTMACATIRYMRVVVEESLKWAHQRLVFGKRLIDQPVIRLKLAKMIALCEAHQSWLETITYQMCQMPYAEQAKHLGGPIALLKMSCTRAAHDIADEAVQIWGGRGLTQTGMGRVIENFQRTYKFDAILGGAEEVLGDLGVRQAMKGMPKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCK2</accession>
    <name>A0AAE0NCK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_477715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCK2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="24585" checksum="BB81EE9BB04A072C" modified="2024-05-29" version="1">MPLAARRTGRAMTRPLITPRRRRRPSLLLRQHLEPRLRKEGIITVTPMCGLYIYEFSELSLAKLRHQTGSWLSSHFNTTNSSFYNCSCKRSPTSRQQSAIASQIRRIGPQLAAPCSTSLSFKTEYANMPRLAEYSSNVRENKIKSGAPGWCMLLPVGPSGSHQESPTGFSSGSGPSFLDCAAPTLYKMGMCLARIREFWLHVSTHQKPRTNLQANLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA4</accession>
    <name>A0AAE0NHA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RXT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_524235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="552" mass="61147" checksum="CF008F9F1E697CBF" modified="2024-05-29" version="1">MSSFSAHSASATSPPARARDNLNLQRNRPILTPVTNRASTKPAIQVNWIVESFNFDTHSFEDDRTLRPAPRSFNKSLAILPSWAERNCFIAAMATQQQAMIMQTIVAIRKALKRKAYESDSDSSIEHNTNRGYKLKKRARYVREGRLAPPTGPAAYKEIAEHAGYHRAIINRNPSLVDEEGYDLDSDDNEEHIREVMASAMEDDPYSSIRLEQLLAPLTAVTDLPTHPTLSRPFTSKALPELVKQALSLMHKENAALWKAKPLLTKLIGDNTWAPCGIMIQPNDVDLFTNTPSFLRRGTTSSLGLADAIPTTSQKPVLELAQREMVDGTDHAAPSDKTSPLEPGKQDTHEVESENQLEESGSRNGAEEAGTASLKEKPEGAQQANGHPPAGEDDRNGNMPGSSGHEDADMAEAAAGSGSRAGSSAAADPLDLPFIHPLFLPPRSAQPDRDLGLPEPEAEDVRRLLQLYVQKQEEVCRGTKTLYEGLLKADRYRRTVWQWAKAEAHSGANRDMSDGEDWYDREEWGLMEDLKKGEDEVEEDTAQTQKKTRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHQ5</accession>
    <name>A0AAE0NHQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_476558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHQ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="608" mass="66136" checksum="7FEA93D8D1F1874A" modified="2024-05-29" version="1">MSFNWRRPFSSRQGAGTITGDNYNANNATTSTFEGGEISDGSLKYTFEKGGNDSLPSYQEASGAPVERHSPLGYTVGPITIIFLNISKMIGTGVFSTPSGILSGTGSVGLSMIYWALGFFTSIASLSVYLEYASYFPNRSGSEVVYLEQAYPRPRWLFPTAFAFLSVALSFSSSNAIVLSQYLFRTNGHIPTPWELKGVAIAGYTVAVLVVAFHTRASYWISNGIGVVKVLTLVFISLTGLIVLGGNVSRIPDPHANFVNPFEGQATPYGLTNALYKIIFSYTGFENAFNVVNEVKNPVKQLRRNGFISLGIVTALYILANIAYLSAVPKADLKAAKLIAASLFFTNVFGPGKAVQGLNILIALSSFGNLVAVLLGSSRLIRECGRQGVLPFPRYWASTRPFGTPLGPYSIKWAMTILMILAPPAGDAFNFIMDLQVYPSAFFNVVMAVGIYLVRFRRRRLGLPRPEFKAWDPVIVFNIAVNVYLLVMPWYPPAGGIYAGDVSFWYATYVVAGIGILAGCGIYYWAWISAFPKLRGYRIRQEVLTLDDGATTHKLLKVPVAELAHYDATHDAVGRSIGESGSEAGRHDSADLKGEEAVGVVRTADLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI47</accession>
    <name>A0AAE0NI47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_561510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI47"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="45616" checksum="EEEDF29B1FD96F27" modified="2024-05-29" version="1">MRRLARLPSSPSVLPTSSTTTGARTAAASLLKCELIKTQNLSSARPNRQTWQNGIQSQRRCLSSTSQLAATEKTTPGSDAEAAAVVADEVVEYEEEEFVQRRRAKKSKRAPIQTDLVFPDAIKGTAAPGEVTDPDYVPAESGLGLEEVGGLEGWWDNPQHWGPSKKYVGYGPREKITEPEMLEVLTRRALTEAIAASFFSQQEKRPGHRSGKLPALSTIEPLKGDTIKTTDKTKLELKADGTPRLATVGDYFRILQVLRRPPPRDEATSLPVPPTPGITIWKARALLKKWQNSDWKSASLADPALKFHVAKRLYYLTGHMVPDAKLLIVKTAGDLVAQVVTPPQPKKLIEVLEASELPTLPNVQMFPRRVTPVDKEKMVGRWKIITKELQQRDLPIIGTGGYGKAVEKKWAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI80</accession>
    <name>A0AAE0NI80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI80"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3382022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="474" mass="52563" checksum="CD5A299696622EA4" modified="2024-05-29" version="1">MANDGNEPEQPLPRLFEQDNSLPVGIHYSSPSTLPFNMDDNAGNLDQPQAPYNASPHYQDPLHAVWSNIIRNTVRPEVPLLVHARPADQPPIALEPRFPSDPFMSRYATAIRKYEARQKMEAETSHVNWHGIAVQDWEARREMLAEVSPVNAQPVHEQDPDHSQPEDNWPGMVDHAFAEPGLPDQSLFGQSIANPGLGVVAELGATEQEWLEWRQPPQVTEEEFDSLMNQDSVVNDDRGDVAAAAAAAAADPNMDEDEVDLVWWPPQYTDEELFRMVSESIQAQMRGGGSGVVAQRGSDVESSHSMSSSRTARSHDHDDDSPRPAVQPSRPLAPTLPRPPPPPPPPSPASQSSPSSSFDISIRPDFSLNPQVNYSFIPCPFPTLPPRPQPVEESKQQHSSATAAKCAIGHTTIHHDVALSSQNYNPHYCSGLDGKTYQQWHKDVNHTDEAAKHLHQRRIRKMVLLARENQEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNW1</accession>
    <name>A0AAE0NNW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_367983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNW1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="25222" checksum="549486D198B7F0B6" modified="2024-05-29" version="1" fragment="single">ISESYDEGTLRGSLVLYNGRIYTMDAASKVSSVVGIKDGRIVYVGNSRSDAIGVQKGLGSREEPRQINLRGRVAVPGLIDCHNHIVLFGNRPGYHTPLEYALSIAEVQAIYRGRARGVPKGKFITSIGGFSPNQFSELRFPTLAELDAAAPDHPVFISTSFSGPSTTNSRGKAFFESLGDNASVVVAANGSITAGLENGKALLSLRQRFLTFEDRKRSVRDAMAYAASVGVTTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP08</accession>
    <name>A0AAE0NP08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_501112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP08"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3384929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="20598" checksum="07459E5379A8D8E7" modified="2024-05-29" version="1">MRCGNYSKSAIFTTGDYDDGGPGVVMRDLDYPNRRQGHYYFFYENDCDDHAWKYTLLKPGVEVFISVRPSFAGRIVRGNPIDSLDGTALHNLGTWVEGYDGAAVLSSTDGSGVVTGFSENILMGATLTNKSDGSTVLGKTVGDEANFATAQYELGLLDPTTQAFIVQAYKPMIATTNGRWDLTLYPGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP35</accession>
    <name>A0AAE0NP35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_394201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP35"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3385097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="172" mass="18959" checksum="C2F8FDF112A99122" modified="2024-05-29" version="1">MLSSLQNPRQAAAQLMNFGLILSTAFMMWKGLSVITDSPSPIVVVLSGSMEPAFQRGDLLLLWNRNLFSETSVGEIVVYNVKDKDIPIVHRVVRKFGAGPEAKLLTKGDNNLSDDTELYAPGQDYLVRKDIIGSVFGFIPSVGFVTILLSEYPWLKTAMLGIMGLVVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPH2</accession>
    <name>A0AAE0NPH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_181543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPH2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="353" mass="39935" checksum="9895390C0B0871F1" modified="2024-05-29" version="1">MLFTCLELMQGRYKTGKTHLQSGMKLLADLTDSKREYTNDWLVGAFTRMNLLATQFGQGLQTPPGPQLPTHSQPLSSMLVFESVSQARDYLDYLLADILHLADTCRQQTDFQDSVQRSSPGQDMLDIQRIKSDLASWLHIYRESSVRLHTQKRPLNEIAFHLQVQAFHQLKDPAYVVSGTEQFFFVADIGWVPPLHYTALHCRVRHIRQRAIDLLQAVPIHEGVWDSVFAASVATEVMRIEQGGVVENCDAWVGNNDLPTVHPELVFQDDEESLNLPTAPALHRLYDVQVTLSDSPTGKATLSYKKGTSDGRFRITTTEYDVSPEAGLIIKKDVDFSNQFPLESFHEFTKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ42</accession>
    <name>A0AAE0NQ42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_473260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="232" mass="24998" checksum="C11E9BF570FE469D" modified="2024-05-29" version="1">MYFLLQSMNLVASSIMSCGVISWPATRTVSISRSTSKQLRPSILTKASLCGPCGGMSFSNWVCEVSLANNSSYFFRMPEFDGLDWKTSNASCHNVRFPSSPSSCSTSSRSCLVSSSDLRRGCGISMAVVLSSRSFDSVDCPVISADVSATISPPRVIPRVSIEPINPSAPADEQAIEEDCRVSVDWDECERRPRDLRNLPGRRLGVGGFLGEVAVRGDTAAVSCAFFLKVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQK1</accession>
    <name>A0AAE0NQK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulation-specific family 4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_544360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQK1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042177915" evidence="1">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="33952" checksum="9575228A69B53107" modified="2024-05-29" version="1">MFLPLITALIATAAATDLLIPLYQYPLNNGAVWKPIEDAMTANPSLIHKIVINPDNGPGGKGFGIEDGWYKNGALNIATHKNAQLLGYVHTSTDGGVTRCNAPLAEVKANITRWSDWVAQGVAVKGIFIDEAPADSKNDCVAYMRELTDFIRNDDTLGFAKPRLVIFNPGGTGALQPYYDLKPTLILALETCFTSAPRGSYDGCFGDGSGYERYDHEGIGSSIDKVLFPNIGKQNAASTAVMVHGFHGSNGPSAGLEATEAVLSSMIQAAVSRKIGALFFNTAWYNQFSDGPADIGTVARLLNAANAGTSSKTFVKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQX0</accession>
    <name>A0AAE0NQX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_191825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQX0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="304" mass="33451" checksum="EBFBC7016C672AA0" modified="2024-05-29" version="1">MASLNILVVGATGQQGGAVVKALLDLPAQSPPIHILALTRNAESPKAKALASAHRDSLTLVQGDATDPEPIFAAYPKESIARLFIVTVPGKIPEEKQAIPLIDAAVAHGVRHIVFTSVERGGDERSWSNPTDVPHFIAKHNVELHLRQKAESDSFTWTILRPVAFLDNWNPGFFSSMFSALMYASLKPETKLQLVSVRDIGVVAALALTQPDKWAGRAVGLAGDEITLSEAQETFKKVTGKDLPQTYTVFAKLLLWLVKEVGTMFTFFEKEGYHADIAALRREVPGLQDFETWLRESSKWEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR91</accession>
    <name>A0AAE0NR91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Infection structure specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_544803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR91"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933145" description="Infection structure specific protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23294" checksum="FC34E31BF15F2EDA" modified="2024-05-29" version="1">MHLIIRFQLLSIFCLAALAASAHDHPTVTWKQNPATTTLQNPAMHTETKRRWPWAKVTIRPLPTPFPTPSLTVPLAPRDAEDCTKAVYSVAPKLTDAPTLPEHLKNIIQTEWTDACVMDDITKEFAARNPELEVFREEAQAWVEAHVGELRDLWQACSDIPQIAHPLTETSICVTLLAEITASHSHNMGPRETGKPVACAAAAVAAGIIAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRT5</accession>
    <name>A0AAE0NRT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_467934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRT5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="146" mass="16251" checksum="CD21B9EEE8576656" modified="2024-05-29" version="1">MSTSKKRQSALSATEAWERLDKIISQPNEGRKAKTQINDAAELLERRVSGKRKIYQTFLRDVLERCGLTSVVLCAIGLGQAQIAVMNEANRSSLLGILVKNKNNPLPPEIVRTDIPQVVIEDCLMFLEVGYAQDIISELFLPNVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRY9</accession>
    <name>A0AAE0NRY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_138364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3386599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="97" mass="10770" checksum="A2D845CF41537034" modified="2024-05-29" version="1">MAPAATGAKKQKKKWSKGKVKDKAQHAVLLDKSTSDKLYKDVQSYRLVTVATLVDRLKINGSLARQCLKDLEEKGQIKQVVGHSKMKIYTRAIATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSC6</accession>
    <name>A0AAE0NSC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_540907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="555"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115261" checksum="7104D485E3885A4E" modified="2024-05-29" version="1" fragment="single">PASNLLVHRLIHDRARLHPDNEALHSLNLALSYGELDSLSSRLACRLAKEGIKPEGVVPLFIEKSVWAVVAMLAVMKAGGAFMPLDVSQPESRIQSIIRESGSKIALASADGFRRCSSLVENTIAVTEETMSAMQHEELSVDSWHAIFNNAAYVMATSGSTGSPKLVVTEHSQMSSFMAYFTELLGFTDTTRTFQFASYAFDPIIGDIFLTLAAGGTVCIPSEDERKADVVGTMRRMRVTLAKFTPSLVGSLSDLTLGPDGVPSLKTLVLGGESATADIIKTWAGKVNLRLIYGATECTMSFVKIVDDTVTLPVIPGEIGLPVGCRAFVVYPNNGQKLQHVERGEVGELVVEGPLVSRGYTNNQAQTDAKFIITSELFHRQYRTGDLVRELDNGNFVYIGRVDNQVKIRGQRLELEEVERNLQTTLSTVSNVVVKSVVVDAAVPLGSSSKQLVAFLSLKSSDPLGSLICDDHARATVNLSSKTQKSLANLISVLETSMRSTVPSYMIPTLWVPIDEMPYTLSRKRDRQKLRRAIESLSTSQLVAFSRDANTNVSTEWTEKEALLRRIWSEILAVDSLSIQPTDNFFYLGGNSLLALRLVSKVRVESQQLSVDTVFSHPVLRDLTTKLEGITQSTTSSLAPFALLDSSEKVTIHQETAQQCAVQASDIEDILPLYSMQHHYITGYPEQGRPLVGPWNWQQQIVFLVPKTFDIPLFKSIWDCAVARHAQLRTRVVQTSCGIYQTVLRHGAAVPAMWSSDEELLDDYAQRDQADTMSFGDPLLRLAICKSTDQSTYFVVTMQHLIYDAYSRDLLFKELERMYRQPSRTLTSTASPSYGEFIRYSNRPDDDREQAIAFWTSYLSGASTKPLLSLPARNKIGDLQTHKFVLPRSHVCQNKDYTLATMIEVSAALAVSHFLGHCLDVIFYSDRSGRNSPVSDILELVAPTTLFLPLRVHIDHNQTVEDLLRQHQAGNAAMMPHEFINWTELREMEHLRPVLGDSINININPYTPLAKLGKGMGLKVETRRLSGVCISMTTLLTKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD4</accession>
    <name>A0AAE0NSD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_447712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32601" checksum="AA7894A82FEC21AC" modified="2024-05-29" version="1">MSGRDGSNTLPRVRRILFTTTSHDQGYSGDPERQGTYLHSHTFFDVHVVEPSGHDRVPPRTLQFNMHARRAYRTHINCWDYRDAEYRADGDPSSALLWQSLGLSLQDWLQSIRNGDSVQIVPRVGRRGVLGELDECVGEDLDAMTVIAEQYSGGVAAPPPSLPELRTTHGIIADHHDAGQGSDDIPFYQMHHTRVFRRPRFQRVWILQEVWGSAASEAPPFGSSVSRSEAPSWALGPDVSGAWWGATLALRATACPYLASSRNEVDLDLLSPANVNTPQHAAACLTLALRGGASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSN2</accession>
    <name>A0AAE0NSN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serf family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_521017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSN2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="62" mass="6443" checksum="AACEFF2747C6FE17" modified="2024-05-29" version="1">MARGNQRDKAREAAQKKLASQKKGNGMSGSELAKAKLEAAEKMRAKQAAADAKKAAESAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSS6</accession>
    <name>A0AAE0NSS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_521109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="29421" checksum="3A5C6E491EACF7F4" modified="2024-05-29" version="1">MEATSNEGEIAQPQQQKRATSDAHFRAFDAYPWAKDQRFFEALMAMLGSGRMDTSNISRSLLDREKSLSITLQARMWWYQTMQGIVVERNAYEVYASSSSSSPPDAAILAKVDVVRENMEKYKAAKAAKLAAAANSVPASAQDSNNIPAWMTQAPQKVDLNKKADDNSTRDMAAGGDVGASYPAQFQAIIEAVTTGKPVAGVREIPNTVVRQEGITPIGKMQAPPKPWERKQQSTPASAILGAGSSKTGGEEAASHSSLIDQEFPPIADANTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTL6</accession>
    <name>A0AAE0NTL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_470180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="82" mass="9332" checksum="6AD3884AB0913DA9" modified="2024-05-29" version="1">MLSRAAVRAAPMPSITSLVSRRGFQTTRPRFSSPYHYPEGPRSNLPFNTKTRFFGLRYLTFCVVGFGAPFGIAVWQTYRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUI3</accession>
    <name>A0AAE0NUI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_167061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="752" mass="84956" checksum="064F947260DE14A1" modified="2024-05-29" version="1">MLCCCSFLKMGRADNPTQLMTAVHKQHAKDPNFPMPIIEKIEEFLGNEEVFSHPEDHALLIQEMKIEAALITNNSPYAEVRSVVDNHDDPAMPVSTLRAWFIGTIFACAISFINSFFDVRMPSIYVISTVPQLLAYPAGKFLERVLPDVGFTMFGVRHSLNPGPFNRKEHMLITIMSNVAKSTPYTNYIVWIQYLPQYFNQSWAINIGYQLLIALSTNFIGYGLAGLCRRFLVYPAYCVWPSSLVTIALNSAFHDVSTETAVVPGPFKSIWRISRLKYFCWAFGLMFVYFWFPNYIFSALSYFSWMTWIAPDNADLAIITGGQTGLGLNPIPTFDWNIVTFNVDPLMVPFFSTFNYFLGAFFSMFVVIAIYYTNAFNTAYLPINSNKPFDHFGNRYKVLTIVDDNGIFDSAKYQAYSPPFLSAGNIVVYMFFFAMYSATVTYGYLYHRHEIAMGLRDVWSSIKTKKTSENTQKVDLDVHNRLMKAYKEVPEWWYMITLAISVAIGMIGIACWPTNTTPAVVLYGIALCLVFVVPIGIINAMTGVQVTLNVLAEFIGGVWVEGNAIAMCFFKSYGYVTCAHALSFSADLKLAHYLKIPPRHTFWAQMVPTLVSTFISVAVLQYQVNIDKICTADAPFRFLCPGVNTFFTAAVFWGTVGPRKIWGVGGQYASTLVGFPIGVLLVLIFYYLNKQWPKNAVFRNAHPVVMMAGALGWAPYNLAYIWPAVPVSAFSWLFLKKRFLGFWAKVCPPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWY1</accession>
    <name>A0AAE0NWY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_96041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWY1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261596" evidence="1">
        <location>
            <begin position="26"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="34682" checksum="5AE0D71D3B0B2188" modified="2024-05-29" version="1">MATHGASLFSSLLLFCLIFIGFTSCRVITTPRPLIENHHIGVDIDNPFYYPSTYNDQVKVSVLSGPQGNLEALELAAARRALKKLKDLLGPEKLKELLKDDIAAGWAEWHDIISSSSSSSTEDDHVVAEVRLTAIPRPDICQSVDFSARNFVGWFADSGFNHVDKLWAGHPEHYGVHLTPNADGTMRGELIEPWGPLLTYSVIPRFTPVVDPAVQKKPWMRALPGFPLQMVGDETLMDGSGVVVGNLHFAFRDIPVSGSVSGEKKTCGVEVVLAMWMVGNTPPDVVEGMRQHLAVEYANWFPKAFDDIRTGAFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX32</accession>
    <name>A0AAE0NX32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_95050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX32"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="444" mass="50068" checksum="A51BCEFA2B9BB1CF" modified="2024-05-29" version="1">MPYPSIPVLFSIHRDSAYSWPQPNKPKKSPRNKLKKRPPCLFSERNIATHDLSQLMGNNVSFENIPRPARPPRPSATDIPELPSLPMYENFTSKHHHPVTVLDEKPRCRENFSSKRDTNWSSPSGPRVRWVDERPSTTVSVVSDTSTIELPAPPRYDRSSRLAESYRALLPDVNAIEYKETRHALRRQHSVWRLHDHQQHMQLQDHRHSTHHRSQHSSRPPLSHNNSCNSAVRTPEHDIRHTRARTSRPTEPSTPASSITAVDSDSQSPIDEWSSNSEGYSPQKTTFLAPSKSSCPSATLSESRSELILRGSDQRTVTSSDYVGLQICSELLTEELTKTLFRQHPADETRSPRASKLQVLLLIEAYEAMLETCRREMLKPPPVRVSASERRRHLKDAVRILDHWLDSLYVIYDEAFGDGDGEAGGGGGGVGLGAGEGEEAEDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXB7</accession>
    <name>A0AAE0NXB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXB7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="100" mass="10605" checksum="C4277A13F65BFC57" modified="2024-05-29" version="1">MDGAGASIQALPNEVLIRVVAELAEGGHFGSIAALAQATRRLSTIVNPQLYTPVSRVQLVAAEALIWAAEDDETRVVVALLLLGVSPDTYFYSSIPEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXY5</accession>
    <name>A0AAE0NXY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_464311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXY5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="111466" checksum="82A2393CC0E70904" modified="2024-05-29" version="1">MSHHGKTLPAPPSTCLSGEPHGHRVSDPTVHYFGCLRVSKRDRFFNTLPLESKQRILRRIDRIDDLRHRLETAQCDTTAAARLRDFKHAMSNWFAAVDRPHASFTPGTAFESSSRRPSGMTAYFGSEDLVNDYIKAPVVYFKDGRPFDVPGLSNSFPSQKVIMSDLLSEDETRNPLMQSVEEGTVRYFHLPANNMAWVEEAMARYYHERPPDSEDLFLKSKSRRPRTKTEMLLRPEYWQGQQNYEADSEVHARHMRPLCSGISTNLVSSESNANNLALFMPYLHWETDRGRINLTRIVKEVGKQSLNTVAEVADQVQHHMADPQAARDTSEQAPPVTQPSGSEEEEKDEKPEKKRRKAIANILRTAAALLEAMDLHTEEQLMCKYLHAKTPLHPRRTLDQSYYGALKSTGTRDRDQVVYRGTTPAPHVCTTGCSECDEADDIDDVKLHKCTSKKKGCPLCNEDARKVPRIIMVDQLWLWILDEQTVITSFPRTWGKHKPDPSAIHKSLRMRFKYAREGEVSSAYDLALMIVDECSRVFFDRTKTNDRQPNLVELFNGAIRDLTYKQTAAFDQFLIYTHLASRDYKRQRSLSDDNSTQNTLLNINPEGYLLKEVKDIIDEIHIMMRIKEQQQSVMESFVKHIRRRLVPIARQKKATASQPSTSWDVVLGAMMQDAGSPYSDETFGAREEQEREEARRTLSRADHLLSDLEERIAELRTQLQNAQNTSAALKDLLTLKQQQAGVIEAREAVKQAQLTLKQGQSIMIFTIVTIIFLPLSFCVGFFGMNAIELNDGLVPLQSIYKYLFPVSTGIILVAFLFAFSQAVFNNSVVALGRSAVSFAYNTTLTWLLVKTNLYVVGREMNTLANRLRDREATVTGTMKAEVLRNEKNIKRMHAADHVRGLTRRQTTQPRPNENDGIASGRTTPFSPYSVGAPGSPFAPPQGNKGLGVSMTELDLEMGEGVSVRRPSSQRYLVPTAGSRHSPGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYC0</accession>
    <name>A0AAE0NYC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_428196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYC0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041766768" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="525" mass="57647" checksum="B2CC3D17E07DC0C4" modified="2024-05-29" version="1">MRLAKILVGTILAVGSVSLSQNLDDPFGRHGWTDMMLGRLAPLRSPPQRSTVRAPRVHPPRYLNNKTAGFAVPGDELPDVLFDIGESYSGILPISNVPGEPNQLFFWFFPSTNPDATNEIVIWLNGGPGCSSMMGMLAEHGVFTWYPGTLAPVWNPYAWANLSNIVYIDQPVGTGFSVGSPTATSEEEVASQFLGFWRNFVNLFDLAGYKTYVTGESYAGKYCPFIAQAMLNHSDEFSVAGMMILDPVIADLDVQANVVAARFAQYHSNTVFRLSDEIWATINGMADRCGHNAYVDEYLVFPPAGPQPSGIPGADDRTCLIYEFIALFQEMLNPCFDRYNIVAQCPRLPDSIGMSSSSEMAVYFDRDDVKARIHAPSGSSWQECNGNVLPFDKSDPPILTAIPEVIARTGNVIIGQGQLDYVILSNGTLLAIQNMTWGGLRGFQQRHVDPFYVPLHSGWQEDDVFWASSGVLGTAHTERGLTYVEVATSGHMIPEFVHSAAYRLLELLLGRIANVSTTSPFSTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYH6</accession>
    <name>A0AAE0NYH6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_464286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="701"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1469" mass="153382" checksum="85508E8605C33AD6" modified="2024-05-29" version="1">MSSQLPSSFASAAAGQIRDSRGNPRGDQVRGSGSGEWPRANGTRTFRRQSNTPSSNSAFTNSVDASHHANSDLPPLSANPQSASLESGPQRYSKEELLDIYKSNSHANIDPSSLYMPNWNPNQVNGVSSRGWGKGSGDSSHVPQDPTVCWEQNATVLPIGLQDMTAEERRTFDDVNSTLKPPQQGKDGNQAGGGSGQNGRKTSISVGSPANHQSSSPLTASRPGARRRETADTNPFSSSALASPTGTGRFPRDDWLPRRSTDLKDMISDEPEEQQSNRPEPPVRGQSFGLPRINTAPNSAFGAGPSSLWGTSSGSASAGMGAFGSFIHTTAVGGDTKRSGTGGSRLAHLIPKESAESSTKPSEAANADANREWRPRHRTDTDPFGGAGDGGLSGSAILGGARDNSPPPQANLRSGGVFDTPVKGNAGDFGMAGLNLGAQGGANGPTSPSETNPYRSPLVADRGDDGPDDDLHNRHGQPGQSAGQQSNFGTLPRTFQATAFDGSDRSQTSSVGAKGFASVNTMTGWPTVPSTGTPDRERQAFQAFGGSIFSPLGEMQSPGLGMGGGMFGAPGGSGLGRGGSKLGSLFPTAMQAQMHGPEQDSLGDSVPDVRQSNPLGAIGRGPVGAQHRDTSSPVRGGRGFLDDLFQPTPFTSGEQLQAGLTTTAQPQGQSFLPGVSAGPSFSTAPASADPSALRTMVMPDRMRWVYLDPQGTMQGPFNGLEMNDWYKANFFTPDLRVKRIEDQDFEPLGQLIRRIGNSREPFLVPQMGIPHGPPPQGGAYAIGGPADPVPPLQNAFPSFGRTLTAAQQNDLERRKQEEQLYHARQREMAHHHHQTFTRLPMQPGVPGSLQHHSSAHSLQSQPSFGSMTSPIGMPPQGPVGGIAPNASFFDGPTSMGQVPQQSGMGPAPDLFPSDLNLGERQMLANMQAAGGLMYSGPSAAGPAGDVPGQRSGLPSIDQLQKDNQGFSTRIKEFHELRAKHDAEEAAAAQGVLPDVVEEESFDTTPAPEPSGNVVAAAARHAVETVSEPAVAKKGSVQVQSELSLTERVRRTQADAAAAAAVVKPVQQAAPSGLPLPFPPPAQSSTIAAPTAQRPGSNLPTRYDDRSASGTPDTTSDGAALAPPPTAPWAPQPGTEAQKGPSLKEIQEMEAKKAAKREEQAAAARRLALEQEALALREKSAAVNPGLPSTSTWGTSSPVGVSAAGSPWKQPAVAKGAAAGPVSASATSKKTLADIQREEEVRKQKAREAAAAIQSTATLVSSMGKRYADLASKSSAPPGLSGSGAATPVPTSGWATVGPGGKAKIPTGPAAQIRTVSSSNVKTTAASPVAKTAPKQVNIGLRDAKAVAMEEFKKWLNRELSRGLVGGVDIDTFSMILLELPLDIELLREQVYQYSTTMDGTHFAEEFIRRKKLADKGIVEKEPVSVSASESKSGNGGWNEVAKKGSNPAPKEDSVPGYRVVQTKKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYP9</accession>
    <name>A0AAE0NYP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_106909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYP9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="154"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="351" mass="36574" checksum="9286B0E121CC0814" modified="2024-05-29" version="1">MSTQPSETAGAAVNRKIQSALPSAVADKIPHIPETKEELKAEIKAEAKIAASTGFTQLRSLAAGGFGGVCAVIVGHPFDLVKVRLQTADKGVYSSAIDVVRKAVARDGLRRGLYAGVSAPLVGVTPMFAVSFWGYDVGKTLVRKISTVAPDGNLSIAQISAAGFFSAIPMTAITAPFERVKVILQVQGQKQLAPGEKPKYSGGTDVVRQLYKEGGVRSVFRGSVATLARDGPGSAAYFAAYEVIKRKLTPKDPVTGEPSGKLSLLAITCAGAAAGVAMWIPVFPIDTVKSRLQTAEGNVTIGGVIRGLYAKGGYKAFFPGFGPALARAVPANAATFLGVELAHQAMNKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYT5</accession>
    <name>A0AAE0NYT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYT5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="28515" checksum="C253272E1927A247" modified="2024-05-29" version="1">MANILLPDILHIIFEHLDAKDVRRLRLVSKSFGRIASYHAFPSLVVPKSEKNIKFLKSTANYGGKASSIKCLTYLILNPKYRLGFHNTLMSDGTLSQKETDDIYKEHCATASKQSTIKHPDDDLRALHEILPRLPSLRHLEILNDTSNYFKLGGTPMLTDFCAIGLFWSNYEFNQFEKHYHVGPPCISGLTESDLGLEEVPNRAGPYQNLNTLRLGWVDWRAFDEDAAKEAEEKILSRSKFENMRLDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZV6</accession>
    <name>A0AAE0NZV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_122922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="15616" checksum="D41B60A4DFB9025E" modified="2024-05-29" version="1">MRGRQAMDFHSPFRLLDIQLSLTSFHYSLGTIHWGLFTGATSRTIGVEFLSQGNPYQSQGSLGFLFAISTIGFGLGLSISTVRSCIRARDAAVLSKMCVSWLLGGKTMTGLLKKHYHPRAVIGFSSSHAPQATYSSRFLFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0K6</accession>
    <name>A0AAE0P0K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_132854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0K6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="289" mass="31060" checksum="9A97279A5EEC6E62" modified="2024-05-29" version="1">MVGVPTSKGCIICLTRGVKCDEARPSCSQCRRGQRACPGYAREMKFVDEGPRLQRLARSAAAAAAPGATSARHSARASSGAPAHVVAMIHIGEHGLERRSGTALQTPAGRAPHLERFNAPKEHCGQAVAVFISNMFPLGTASVQSTFLGSWLWHVPPRLGRHAFLDGAALSLALAYFARLSRDQLVLCRAELSYSAALKSLAKVVADPSGRLSSEVLCAVLLLGYFETFVDRGHAWIQHAGGAAHLMRLRGPRQCYDSTFDYSMFLSCRGAMVYCGSSRFRGALLPGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P1C0</accession>
    <name>A0AAE0P1C0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_411354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P1C0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33956" checksum="B4B2AED0468CBD81" modified="2024-05-29" version="1">MVTMSSGAPHSQPRGVDQRNNHDQLPKRHNVATTLNYWKDPGDGAEPSPIVVGGGDAANRAPTVAYDVIVRDITGDEDKYTLDTHGFQFLHHPFNARNIESFSKPKLVKNAYYPDIQHLLMRLTGASRVFVFDHKARRGASHWQALGVTNLANRGPVTRVHVDQSYAGAEMMLRWYLPSEADELLKKRFQIINVWRPITPILKSPLAVADASSIPQSDLVAARSVYQNHEGESWTLRPSPKHRWYFKYKLTPDEVLLIKCFDSDTSVGMTRRTPHSAFEDPAEADKEERQSVEARCFVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3T9</accession>
    <name>A0AAE0P3T9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_530426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3T9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="54877" checksum="3831B4A55666C5AC" modified="2024-05-29" version="1">MGIDMEADHLYSRQTPEEHLCAALDSFKLPEPSSTAPAPTSPPTECLRSALQRWLTQDKTSRATSHLYYRLDNMYLDDSYFTLQSLAKRDMAVVEALAKLVSDLLFELFLAMIQKDEVHRPSTVCAYILMEENCLPQHDPPSIGARPPFYEGALLLVPRDSVAGFLLDCAEAPDDLTIRYGLTSAHIPFIVEYYANMVLKPENCKRLVPVLKDLCTSLWDVDKIRGFALLPEFVVDEVFRLSCESWICPSVTKTFPRLVAAFPSPSSTGLAPKILKAVLSFPDAQRRCSAILSFAKQPEDEKFELWARQAFEKVLVETGSHPLGREDSRSLVATAYTILGFKGLVTLLPILSRDVSQTSFMHGKQNNCFKWLVRMTTKAPDVTKLSSTSTATFRLTKPPVNTKNPLMRIWYPEPPLVTSAVDAEELADFVAALLTEKVDDTIILQLSFKITANADFIGERKFVSLWLPFLRLLIGVLEKHKIPLSFPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3Z7</accession>
    <name>A0AAE0P3Z7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_3393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3Z7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="29145" checksum="02D6D6F25EB7F9C2" modified="2024-05-29" version="1">MAGRTPLRILCFGDSLTSGYSNMGCISHPYAEKMGQMLEMAYPHFDLEMVEDGVPGATVKFGFLKRIERHFSRKKDDGTSYFDWSIVLGGTNDLAMQVPPEEIFQHLKAVWDVALSRKCKVLALTVPEAGVTTSREVYDRRRNRLNDLIKGYKREGFHVFDFNAAQPYFAMSESDRERYWDDLIHFTSDGYDRMGNKIGLHLVSILKKEEIAAGGPPTKRRRVFRDDEKVFEEEIGDPHAIDQGWIVVRKKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P401</accession>
    <name>A0AAE0P401_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_7998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P401"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="241" mass="25883" checksum="E7FDB723EAB40EB5" modified="2024-05-29" version="1">MGDDLTLINAFPIPQMGACSSAKLVLPGYLKQASKPRANSDSKMGGYANSADLAWNSSSSNVNSRLGGSSSESSQMMTPIQVAVIMSAVGTFVGIIVMVFYCRTLQVRRNKDMKNREREKEEQERHQEEGEVGGGGGDTTGTESIELKECPSTTAMGSTTDHHSSDTKPLATSETMMMTTTSAAPDLEGGRGKAAKPPPIWKYIHWKDPYPNPVEPARPRHGAHGKLASVLSPLCPIQVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P465</accession>
    <name>A0AAE0P465_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P465"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042253770" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="201" mass="20108" checksum="6EE1D589F3E410F4" modified="2024-05-29" version="1">MFSTRILAVLATMALGALASPVNTTASNAAIDKCSLVRCASGTTCVVIANRAVCIPIPKGEQCGTKVCPYGLTCCNASCGKCVEPGMMCTQEACLPLALTVPAPVAPTAINPLPPRKQCGPTLCAVGDVCCNSSCGICTKPGGFCTQQFCEPKPPLSGDGIICGATVCAAGKVCCNASCGICTDPEAACTQQVCSSSAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P492</accession>
    <name>A0AAE0P492_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_516186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P492"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="783" mass="86984" checksum="8EA64E6504CC54C9" modified="2024-05-29" version="1">MKEKKATIASDPPPVLELAENIALLSLFNQTPTAPKSNHPSPDLLKQDSGRVLSFDREQSLTTIFSFLAGVSDDPDHVVATCVEELPGRKGIRVLVAINKLRTACGDKVLARIATGLGTILGLLSRVNNELHPAREGQVLDAIIEMSRDRILSRIRSRKAKLSTQKKEKAFFGVVVQGVLTAVRTHPGPQASGSEISSFISHTERLQNLLGSIENCGPKDVRNQLGELVRMASRFPKASNFSRLFSGINPKNLNPSYESRFINCLKKLARYRESSLYLFQTARNLDVFEDARVVKVSLDDPHFDRDPSDPSKCDLSHAFSRSFKGSELSFSVEAVCARLGTRVATSNSAFVVNADKALKKSKIHAEIQIIAYYELRPNVKKPRVISSSKDACYMCNLFIHHHGGFHVPRTHGRVYPGWRLPNRPAFSSLRSKMNECLKEQIRSDIKSIMLSKKQRITNMPTESTVFSFSNSMSSLASSIVQRGPGPTSLEQVKINHSETEKHTTDEEMALKSPERLESSHTDVYSLHHEVDGPSQLRSLVEVAITAGNKVAETALQEQPSPPEHIFCGVSHQESQAPAQETYESQILARPDSPHESIVHEPSSEFIERPAPHRAPNFRPPISEALRQRRLKRRQHQLQRQSRDSAVKLLDTEIADDPLPLPKPPGSDTDGSAVAAAAVKMLIQGQVQTFRLDINTTSHRKPIPVYSTGLLNIFLSVVPRPATVRLHWLSEEDVRLQLASRQGLRGDLSRVQSLSFSEEEDSGSRDVVHLEEGGHVVMVEIMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5E8</accession>
    <name>A0AAE0P5E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_26029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="24745" checksum="3586A2A121DB2207" modified="2024-05-29" version="1">MRRRGCSRPFPRVELEVLVDLDMILPCTGTHAWIGFGFFPHFPNEVNPSQMVLRVRRQIAATCPVPVVSMSRSPALIALDFSPPSASPSGLSSSTAKKGSRHVSSGPLLLPTARCPRHILHTFVLGGLQRHLLLAACCHGDPGANRNMPPQRLIDPAWFPRMTTHTAEIEPSTPTAHVGLQWGFSFSADRDHRGALSSRTVHCLSSPDHAKVCRDTRMLACPKQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5H4</accession>
    <name>A0AAE0P5H4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_498729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5H4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="615" mass="66727" checksum="986754F676BF4745" modified="2024-05-29" version="1">MADEVYDGAIGIDLGTTYSCVAIYEGTNVEIIANEQGSFTTPSFVSFTAEERLIGEAAKNQAAMNPENTVFDVKRLIGRRFDDPTVKKDMESWPFAVVDDGEGSPKVQVDYLGSKKTFSPQEISAMVLTKMKEIAEVKLGKKVEKAVITVPAYFNDNQRQATKDAGAISGLNILRIINEPTAAAIAYGLGSGKSAKERNVLIYDLGGGTFDVSLLNIQGGVFTVRATAGDTHLGGQDFDTNLLDYCKKEFTRKTKKDLSGDARALRRLRTACERAKRTLSSGAQTTIEIDSLFDGEDFNMQITRARFEDLNAKAFSGTLEPVAQVLKDAAIEKSAVDEIVLVGGSTRIPRIQKLLSEFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSADTADLLLLDVVPLSLGVAMEGNIFAPVVARGQTVPTIKKRTFTTVADNQQTVQFPVFQGERVNCEDNTSLGEFTLAPIPPMKAGEPVLEVVFEVDVNGILKVTATEKTSGRSANITISNSVGKLSAGEIENMVNDAEKFKANDEAFSKRFEAKQQLESYISRVEEIISDPTLSLKLKRGQKEKIEQSLSEAMGQLEIEDSSSDDLKKKELALKRLVTKAMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5J1</accession>
    <name>A0AAE0P5J1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_22696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="492" mass="54499" checksum="6430B63AE132D7A5" modified="2024-05-29" version="1">MTTPGQAAGLSMLPGEILLHIISFLEPHQTTNLQLVSKGFRNLARDDNFWRSRCLQESTFIQAVEHSRLFRQKAVEPSALDSPQQGIVGSYPSSNSNIPIDDGAVGGTPATVLVRTHLPRSTEARERERVRIMANWDPSFPSEHVSWYEEYIQRHGPVVINWLEQSDIRDSSGTELLEARGVALYRPDSPQGNEDSCIETLLAVSPLDDGSVCLWDVNGTKGKRGAIVAKSRAGILFIDGPGADNSRRSKRVDSGVTECVSVDSHQHRAYFAVQGHLIEVDLRRLSVVGCESFPFSISALSAANPTVPLTVGTSLGIYLHDSRTRKTTRNDPFETIDDFDRMGANDFYQRTLRRIFDDEPLPPYAPLAQPGPLSILHLERPGLADLSDDIYVAGRFSNILHYDRRTFPSIKDTIYSGARLCSLASLPYPFSVLDNELRRRGQMSLDQVENSKTSAGGRTLIACGEYNTKGSLEVAQRAVRRGVHLCINARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6Q2</accession>
    <name>A0AAE0P6Q2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_517468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6Q2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="34622" checksum="E00C909868A8D0B0" modified="2024-05-29" version="1">MPRPPKNKAVAEAPKPSPQPLKPVIDYDNFIRVRDSVHQRLQTIQELIKSFSNDYLRQTNLLIGEGTSIEGGGTGELDNIAGALQNLLPGGVFAPPLPAVEEKKERKKRTHDPNAPKRPLTPYFLYMQTARPIIASDLGEEAPKGAVQEEGQRRWSVMGSAEKQGWNTAYQYNLRLYNARVHSYKRGNLDAKNMTDDEALKYADEFNVEMPTAAAVVEDVVGNDHEAIAQQLQQSAVAEASEEEEVVEPTPVAKTPKKQATRKPRKTATPAAEAEPAKIAPTPSSPEVKKRKRTSKAAEIEEPKKSGRKKSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7M3</accession>
    <name>A0AAE0P7M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_517914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7M3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="53268" checksum="60AB73665D68C082" modified="2024-05-29" version="1">MAEQDFDMMDADLKAGKGKNRDDSDSDGDGYGDVKKFVPSRSRTLRSSSSGRSRHLSKGPARAPRASHNQTIGSFRQPKGPASNLWQRTAGKPGYIVDDDEDDGGEYTGTRRRTTHQSSSPSLRSSLTPTGYTAAARRPAIRASAAKALGRMNEWVGDDSDKEEAEEEDEDDGKEKSDGYEDDSHPPRPRPRKLRRLGGEIPISSLLPAANASRTHLAAGYSGTRSTNSGTKASNSSTKEEKGEKVAEKDQDPSPFASFDRRELVLKLYRDLFNSDHQPTVLSIEPIPNVWEGPWLPVPPRRGQNQNSTDSSNGRQQPLCVNDIYHEDVFEATVEFRPPPLPVPPGYEEYAFCNFPRSSKPEAAQYNTPSLRTTPAYHPFNELVPEQLQLLHNDHHLLEAVQTAWRTHELILDARNRDGDMAALQLLWEVVDVRRRRITVHGFSQTVRWFVDKKRAFMRDDGLESKSDSLPTSMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8F1</accession>
    <name>A0AAE0P8F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_65371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8F1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="352" mass="38725" checksum="EFE3C64D75A52A49" modified="2024-05-29" version="1">MPSSNPGQAPSSGPPYLPTTASPGGLPTPIPDDAVSGVLLLFFVCGAAFHMTTFQINRRRGHKFIFSVLLFGFCMARIAALTMRIVWASYPTNVNVAIAANIFVAAGVLLLFIVNLLFTQRMVRAYHPNFGWNRTITMAFRFLIGSVIALLIMVIVATVHSFFTLDPDARQKDRSVQLFAGTYLAVLAFLPIPILTIASLYPRSHPIEKFGYGSFRTKMYLVLGTATILTLGAGFRIGVNFDPRPINQPAWYHSKPAYYCFNYVIELIVVYSYGLAGFDRRFHIPDGASGPGHYSGANKSPSSTARDEEDVVTDLETLKAPDNQRDRSATLRSVDKDVTGEHQGVHDGSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8K6</accession>
    <name>A0AAE0P8K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_534037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8K6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24418" checksum="9C76D2611476456C" modified="2024-05-29" version="1">MSCFRPVDVENTNKTNTTHISLFQSSTQTISDNEFPTKPAFIADAIGWEGNRAHSVWRWLDEHTVVFHEKNFEDCKPYYASDFVFVKSTGEVITDEAVGAFHSQYALFDSFFHEPVYSTIVATDDGHRLMGSARLFVNLLTPNRLEGGVEEEGKKHVDMHGRKWDYVGQAVFFDAVTDPASPHGRQFTQMQAYMDPLHILASAVERSVIPAEVVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8L1</accession>
    <name>A0AAE0P8L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8L1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042120343" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="140" mass="14590" checksum="F11753C068EBC5CA" modified="2024-05-29" version="1">MHFTAVVISLVLAPVGALAWAKAGNGVWVANNKVYPQVGSYKNVHESCTRMNSNIVLTSGDCAYWTNSKGEIGHGYCHVTSNSVECKRGCPDPFDVCSYAETDGSCSHGYSACLQKMGCDGRSGGADCIGTATGCAAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVF2</accession>
    <name>A0AAE0TVF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_474716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVF2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="24179" checksum="8F6140D6D508F10B" modified="2024-05-29" version="1">MSVSSSGFALRINGTCQLNEVDCGATVSPYHACCPEHSFCPSQYNVNCCPTSENCTRSLLQTPRCANQTWDLYDNDGFFCCLKGFVGYASTSNSDGCASPGYTFQSGEVLLRIISAGQGATSSPATAGVTSNTNTMISSPTTALPPLNGGQGESLGLSVKAGIGVGAAIGGISFLVVIALVLAYGIRKRARTGHGRKQTERADVPHPGHSELGDTHHYELDGKAIPAEIQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVL0</accession>
    <name>A0AAE0TVL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS peptide transporter-like protein Ptr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_510935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVL0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3380995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="625" mass="68448" checksum="D1A93751C9E4A354" modified="2024-05-29" version="1">MLDTKQSLDMTQGTSMVEPATALSRAHSEVEKASSLGSNDPLKPYPTEEEFATLPRVPGSIPWTAWTVAIVEFAERFSYYGTTAVFVNFIQKPLPVGSNTGAGFLISPGSGALGLGQRASTGLTTFNNFWSYVTPLAGAYIADTYFGRYLTIQYSIVFALIGHVILIISAIPPVIVQPTASVAIFAVGLVIMGIGTGGFKSNISPLIAEQYKDDHAYVRVNKKGNKEIVDPAVTTARIYIYFYMLINVGSLTGSLAMVYSEHYVGFWLSFLLPTIVFLIAPMVLLYYKKFYTLSPPTGSVMATAYKLLRLAFKGRWSWNLAKTKRNFKDPEFWNVVKPSRIAPADRPAWMTFDDEWVDEVRRGVLACKVFLWYPLYYLAYNQMTGNLVSQASTMTLGGVPNDIIAKLNPISIIIMIPLMDFVLYPLIAKCGINLTPIKKITAGFVLAALSMVSACVTQYYIYKMSPCGDHINASVKAGRKDCAAPFTVWIQIFPYALIGLSEVLASITKLEYAYTKAPKNMRSTVQAIALAMSAISSAIGQGLTALSEDPLLVWNYGSVAVIAMIGAIGFWLTFRVADRDEDALNNLKHSKYEGDAVAVEVDTESLQSRQVGTSVDEKAAMKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ01</accession>
    <name>A0AAE0TZ01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_172340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ01"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3384848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="396" mass="44918" checksum="D42A5C9F20DCA4B3" modified="2024-05-29" version="1">MREENHKTKSLHPRRSLDQFFYSSLPETISGDHDQVVYKNTVNAPGGQMMIMVDQLWQWLLDSSHSEAQPAIFTCFPQKDAENGTNSEGVDDTADLRRAIIDDINDRLSDENSPRIAEGTNVAGVIIERAVNVMLSVRNVQSLDFWDIFRDAVGQAAEQQTKFFRLFQNKLESETGCISDSTTKRDGVKLALEIADIIDELNSISRLFEAQIDVLDTAINALSTRDERFAKLRETLIDIVTQDITGYKKQVKRMTEDAQRTKDSLMDLLDLEQKEESLEEAHYSNEEADTAREQADETADQSQILFLFTIVTIIFLSLPFFTSYFGMNVKEFTGDEGNTDQRFIWTIMGPLPGAVIAGLLGVAFYMYRKTRTKHMMRKRNRRLGNKPANGVSTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZR9</accession>
    <name>A0AAE0TZR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_183581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="232" mass="25521" checksum="683C28315BF97B59" modified="2024-05-29" version="1">MELQILEPRPQASPSRLPPAGRRKPTAAARRLSRRPTSTTLASRCSISTNPFPPPIAPNKSRRAAIRRHWDRILDWFEVVLLLAGLALFFTALIPSQGRNRFLEGQEGGDAIGLLTFAMPLAVLTFLSMGMQECVNLDEIDPLAAKTGERRSRMTRPQLRFVLGLRSVVFVYAVICPVLLIFAPGGLTSKSPHYRHYTAEAVALALAALIAVLAAFLIADAIERLRAWKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0A0</accession>
    <name>A0AAE0U0A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_189010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0A0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="369" mass="41554" checksum="12FA98E3A6303EEE" modified="2024-05-29" version="1">MGATSHGPAAQTEPAQSSAGDEPVDIFPAEHWAQQELPPRDDDDNDSSLGSDILSSTASLSASILEYRMIHGRTFHSDKTTDAQYWVPNDDKQNESMDINHHLLTLVLDGKLFRAPLDAEKIKKVIDIGTGTGLWAIDFADQYPDVEVIGTDLSPIQPTWVPPNLRFEIEDMTLNWTYRPNDFDFVHMRYLFGSVENWTALLRQAYRACKPGGWVESFEASTVMDSDDGSVKVGSPMTQWGKVFQAGGEKFGRTFRVVEDGIQKKAFDEAGFVNVTVWDFKCPLTTWPADRKLKEMGAFSQMALEQDIEGYVLFMWSEVMGWSTKEIHVYIAHLRNQIRDKSVHAFFRQRVVFGQKPEKQAAGTGESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0D8</accession>
    <name>A0AAE0U0D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_474048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0D8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="292" mass="32578" checksum="6BE460B5E511CC7F" modified="2024-05-29" version="1">MQVDDIEDELRQSIAAFAIPSVYCLIRIICTRISSPVLHPRPDWYILFTSWFASGVAGSTLAVLTARTGDVRFRLGLKGVGLLSVELLLVIVFSWVFQIYRDVPKPLWLPFLAAFGAASHSFLLVFGLWQVIVGGVEFIWLAPSTHHFVLFLFFVSLCIDRGYYWGWTWGWQKFGWWGVGFLIANLVAFVLPVVSVALRTTWAHLSQCLSCFVVVLFYDVRICWKWWDSLDDKSSGMDLKMLCRGTVGAKTREDGSEAEGSTGSGSWDGQAGVRPPPHVHIRAQGVGAASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0I0</accession>
    <name>A0AAE0U0I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_433933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0I0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947411" evidence="4">
        <location>
            <begin position="23"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="123"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="430"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3386094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="580" mass="61063" checksum="735C01D2D5FC5E89" modified="2024-05-29" version="1">MHLLQQWAVAGAVAALLPASAAAPSNEPRAAAASCSLSSKDTYDYIVVGSGPGGIPLADRLSEAGNKVLLLEKGPPSSGRWGGTMKPSWLSGSNLTRFDVPGLCNQIWADRNGIACTDYDQLAGCVLGGGAAINSGLYWKPHPDDWNMSFPPGWKAPDMQAAVDKVFSRIPGTTLPSADGKLYLPQGYNTISAGLTQGGWTSVDANVQNDKRNKTFAHTAYSFIGGERGGPMATYLVTASARKNFVLWTGAGVKRVVRTGGHVTGVEVECGGTTGTVSVTPNTGRVILSSGTFGSAKILWRSGIGPKDQLDVVKASSDGSSMISSDQWINVPVGNNLYDHVGTDLEIAHGNIVNYDFYGAYTRPIQGDTQAYLNGRTGILTQSAPNFGPMFWDIITPADGINRHLHWQARVEGSRSTSMTLTQYLGTGSVSRGRLTINSQLKTIVSKSPYLNDENDKAAVIQGVQNLRDALSKVSGLTWIRPSSSQSSAAFVNSIAANPGSRNSNHWIGTNKMGTDDGRTGGTSVVDTNTKVYGTDNLFVVDASIFPGHVTSNPTAAIMIVSEHAAAKILALPVAGAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0Q6</accession>
    <name>A0AAE0U0Q6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_468012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0Q6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="595" mass="68684" checksum="AFDDF2BF0CF35907" modified="2024-05-29" version="1">MAEQQSTNTDAHHRFLGARESFKDYPCNLIQSEQFQHELDEYRKTLSDDNREHEYFAVRKRNICFWDQADTAGDFQSKNKINDVDLEQLLPDSRPDPIARFVFIYSRSSRTSLSCSRDQLSRILTHHQTMAPFLDLVFKFRERAEPETVSAFRHEDRLHRSNSVFELQNLGRSGFCIQHCFNLISVEYDIVAQEWPWPLRQTATYHSFDPVTGRACWISLKGNDLISNRLRRSIPVHSLLQPSALQTPERRFSATLLIHLIIFHWSVENWPKAVDYFDTRVKDHIDKVEFGPVPARAVPQNATAFVIQKTDESKQSSRPSTKLSSLHAIPQVVKRVSGKMHKGLFTGTERASADNQEEKEKRQERKKWGMNINDDKMFNLDEAQNLVQLGDDINTYLMVIDQSVKVINEITTRYSDLLESPDFKSHINVDECQVDMAAFLSKARQLVRDMENNAARLRNILGILESAKVQFNMVLQFRNIRASENFAQSAHESARSAMVMEHLAIKTKQETVSMHSITILTMVFLPGTFLATVFGSGILRWEENGDSWAARLPGLVFFLEICLPMTTGTVGIWLIWNWLVKRKERAGFWRTAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U101</accession>
    <name>A0AAE0U101_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucanase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_540983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U101"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF2">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041776967" description="Glucanase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="400" mass="43607" checksum="9D9A51065A5D10AD" modified="2024-05-29" version="1">MKACFVFRLFLLSFGVNALSLNANPNSEPAANASCPLVSLDARTNIWAKYNLHPNAFRRHQVLAAAAVISDDLLNKQARKIADVGSFYWLDNTTNMQKVEEILPEVPCANIVGLVLQGIQDRNCTREGFSVPDHERYQRSYGDPLATLIRAYPRTAFAIIIEPGTLPAIINNPNVSSCQALAKSYRQNVAYALNALKLPNAITYIDAGHGGSLGRDVLLQPAAEELAAVYKAAAYPSQLRGIAVNIGGWNSWDARPGEFETPYEEPASKRNRAHNEKIFSQLLGRALDKLGVPSNAIVDTSRNGVIGLRYEWEDWCNVDGAGFGVRPSVVPGLGEQHADAFVWAKAGGVSDGTSDPSSVTFDPFCGRRDAFSPSPEAGEWNQAYFEMLLRNARPVIAVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3B3</accession>
    <name>A0AAE0U3B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Immunoglobulin E-set</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_96928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="32096" checksum="0C4C0E47BA353BDF" modified="2024-05-29" version="1">MGQRPAHPSRSVSFADGEREGTAAGRPYGALPRTLERVPSGVTDGILMSPYTRYGSPHPCLIREVRELMNGLDRESELDSGLCSQLGETAEIPAPGLLGQIRAKLAFLRDRLRAKKANWKKRPDANDESLQRYKESLGLTGGNDLSDPNDPRACIILSLSMEAEGRDPVVIDLSTPGSEAELKKQPFKIKEGAKFTMTAKFKVQHNILSGLKYVQLVKRKGITVNKTSEMIGSFAPCTDKKPFYTKTFNEEEAPSGMLARGNYTAISTFVDDDKKTHLKFEWAFSIGKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U403</accession>
    <name>A0AAE0U403_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_507566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U403"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042220576" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="103" mass="11069" checksum="76AD20A83B5134EF" modified="2024-05-29" version="1">MQLLQSSSVVAVFLGFLAGTDARILLGNDFSKNVMWFDGDSACTAKVISNTNENPCGRPIAMPNGHTCQLYILNGDGSFNSACTFSQSNTGQCGILRTWRCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4Z0</accession>
    <name>A0AAE0U4Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_507942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4Z0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="563" mass="62853" checksum="FA4F34F3864D2D24" modified="2024-05-29" version="1">MLSLPFFLSQPWLTSPFALAGVSAFLAATMVYFAVAVHRDSVPALGGGIFPLATNGYLYLVNQQSFIYRLRHAFRSTNITRFYVGAMKVYAITGAHNMQAMFRTSASISSDIFIMLVIEHLWGAPADDLKMLGADKTGRLKTPIQEGSKKTPVVMDENKRIWYGFHKIVHEYLAQTAATNALAASFQRLFAQKLGERFPVVGEWTDVRVFEFLKRDMAESAIVSLLGTRILEVNGGGDEFIRLFWEMDAVLISLLWGLPHWMIRSAVAKRDALNAACTRYLEAAWAEFDWDGPEAHADWEPVFGSPFGRHFAKWIKEVGLSPKAMGGALAGVGVGGQNANTVPIATWCIMELAKDPATFHAIRDEVSTTWVTDTATDKRIIDAQKLLALPLLQSVYSETMRLHVSINITREVVDPIMMEGYQLQKGGVIQASTEIAHLDERVWAVEGHPASEFWAARHVQYVDGTDEATGKTIQVPQFSIAGKTNNFFPFGGGVTMCPGRHFAKQEIMVAVAMLVSRFDFEFVEWTNMDGTRSDRPARNNEKYSGAASVPPDRDLRLRWKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5E9</accession>
    <name>A0AAE0U5E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_132569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5E9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932865" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10812" checksum="82D84B2F9D97DBBD" modified="2024-05-29" version="1">MHAPLFQFLCALFFFSERAARTGHSISLSGLRHRLVSGRYPQWTMVSSASETCQGSGLGWDFRLFLFVPPVSTDSLTNNLYLLCKRLLLDLPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6J8</accession>
    <name>A0AAE0U6J8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_424684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6J8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041975767" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="127"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3392873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="419" mass="44499" checksum="F38F436099C0F519" modified="2024-05-29" version="1">MRTTAHFVIGAIAGTVAAMPAVEPRQAECAGLPSPYPTWQQLPLQSTLPDPFLPLKYTSTDNAAGSSTFAQDVMTGKGKNRIKTPEEWYKCRQPEILQLLQEYQYGYYPDHSLEKVEATRSGNTVNIAVTAGGKTGKFKATLSLPSGASASKKAPVVINIGGMQNAPYLSAGIAVVGFDYTSVAADSNSKTGAFWDVYKGRDIGVLTAWAWGFHRTLDALNMTVAEIDPTRVGVTGCSRLGKAALAAGLFDTRITLTMPMSAGIQGIGPYRYHAMSGQDETLENSKSGAGWWSNSKLGTFVNHAENLPYDAHTIAAAIAPRALIIDQGTGDAYTNSKGTAVVVYPAAKLVYEFLGVGDKIGMSVRSGGHCDMSGFSSILPFVQKTFFGTPTTKDFNSLGTYGAAQTTTFPWATAVPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6P2</accession>
    <name>A0AAE0U6P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6P2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042167235" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9731" checksum="E73391F4B6EEC42A" modified="2024-05-29" version="1">MKPFLGGGLSFLFLSQLSFVICSTVAHDLQTPLSRRERHEISSFGNFFFRFCFSLAHSVYVRVSACSTFSFFLGSLSVGKSTCPSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6V1</accession>
    <name>A0AAE0U6V1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_456610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6V1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042072947" evidence="2">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="252" mass="24921" checksum="C99FCF08095AF5C5" modified="2024-05-29" version="1">MASPSFSWRQVAITALLFTNAAYAIPARGGEDGAAPKALATRQNNNKLIQDLLDFFGAGTKVPAVAAPTLPAVVIEPAPAEEEPKGKGKAKVAPPAAALNLTAPYPLNVTAALNGTEAAAANGTEVNAGKGKGKAEGKAKGKEAKGKEAKGKEAKGKEAKGKEAKGKEAKGKEAKGKNATAIAEPAATAGKAKGKADLAAVEGKAKGKADAAAGVEGKGKGKADDAAVVEGKGKGKAVTVNDLLETLLGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7T4</accession>
    <name>A0AAE0U7T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="15326" checksum="B07CE4959C92EE37" modified="2024-05-29" version="1">MSGTWRSGPTEKNSSGESSRDEGSRQQQQSSKRASAIQRKATSALSICVQCESPSQPEEDGARELGYECSYHSGIMKPDLILNGEWWKVEDPNALELDTMRISDAERFICSCCDFVGLTAGCRIGPHQAHPDKSKRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8H6</accession>
    <name>A0AAE0U8H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_46741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8H6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="580" mass="63259" checksum="534C9002EDBA3FB9" modified="2024-05-29" version="1">MSLSPTTGFSRLSLDAIPVTNQSKKLMQSSRASTSVESEEYSSEESDWDEDDEESGRVISSSTGLNYDISGLPNKTQEVVRSLFDQSPAKGPQQISLELCGIKKEDAEGSGRFYAFQMNEVVPCSVRIGARNSARFSTPKCECPDSRYRHIRPCKHIVWLFDQISKQALFDHDPDSHLTLTELGYAEELRDPFQQISQISLDVLADGLRCDITAPNSDSAPPSKTRVREAREMIASLAGVQPWGLENYRLDLESSYDSNNLIRRGDIEGTLFSLILASHSLASWVRSELHPSDSAVDPFRNLQHRVLRIIMELDAYSSSLQDPSAALARREDGKETEGPRDVNWAATQIRQCVVQIERLVSRGSKPLAEWERSSAARALVSILKAVASHNFDSHGGNAADERNLYMSLVGNHDTGFVFSTLDMLVEQSQFIEELEGVMELLGRYGTPATYAGNMRSLITRMRSQTAADSRRDSESAAGPSTSNLPRSKTPSLEMMPPPSLPAVDEPHNSNIFDTLGSGSGQFLTPEAPASASSRGGRGRGAHGGRGRGGRAGGSSRAKAGSKRSVSGSEQEGGKGSKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXW7</accession>
    <name>A0AAE0JXW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_490295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXW7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="23483" checksum="3AAD9E560F01E6D1" modified="2024-05-29" version="1">MTLLSPRGSHSHSLDSPSISSRQPSIPPPSLPSPSSSYLDQPPIIIQEQARLEYRVTSRYAGLRHSLQLSRAVGALSDTTSKSWLPTGEGRGLRSSKIHRVPVSTSVFRSGRCDTTRQRQAGGRFSGWEDRVGHGETDRAAGCRPFHRQGRPSGWAATDGLTQSKLNPRSTGISDAASTSCSLGAWGPRAYELPASHGVHWSELTMPSRVDCNLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYP1</accession>
    <name>A0AAE0JYP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_90980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYP1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="206" mass="24693" checksum="D03B703B53C4C87E" modified="2024-05-29" version="1">MATLPLPFRPRTNIKSSSRWLDFLEISRCQTLYRNHRWQHYQYTTINTPSIHHQYTINTPSIHHQYTIITPTAEAINMREEHLDQQSPVGGGLPKITSLQLKFHLNDCSVCKVVKLDILGGYHLDDSLSMIFDHIECLLVLFTLAAPRLENYRLFTAQVLTHYLSVRRGKRRGGRKKRRKKRKKRKKRKKRKRRKKRKERKKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYX8</accession>
    <name>A0AAE0JYX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_405371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYX8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="409" mass="46115" checksum="D85109D11B203352" modified="2024-05-29" version="1">MVQSGQKIKTQLRGNVHYEPNDDELAVIVTAKKGIRISNAEEVCNFYDERFKSCQQTACKLIAKIFIKTIAPKKQSNNPYASKDATAPDWWPKPWGPTKDEKVRHKEPDHLWKKERVYLLIHILRMVTEPNHKQHKDIQRLDITISKLEETTMGALSTWFADKDKPAQALKKTFLEEIFRIAKVEEQYKNDEIDAGTEVFVRINDNAYHSDDNASPLKEDILSMANDHKPTVTSAQMDSSFISEIPVRVPQYRLAMMPSELASVQHTNVESGDMPVSGQGPLHASTTMQMQDIIPGPHDSSRRPSLFSGQSEFRGPSGSTHWQQQQQQQQQQQGTTAPGNAWPNSSFPLHQPAPQPPGAYISQQNAQATNQGQQYPFDGLSHTPTTYRSGSVRQGSVSHGQHCYESYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYZ5</accession>
    <name>A0AAE0JYZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYZ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="68508" checksum="0A959BFDAF8ADB25" modified="2024-05-29" version="1">MLAVDDYETSLGRIRLAVVYYGKLWTTLQQPPKGDPAQEPDRTCPGTRSEPPCDSVAPPAAECNSPSSQIALRASVPVPTYGRAPGLSILTPPHLPPANSDVNVPLSESVVNKIVRDATQELIQGAKWMGQQPRSPTMAPQGWGGAGAARPEPPQFPPTHGTMTPPVAKEPVIVSILDIESMGTSANLHPITTFGIPHGCSFLSFAPSGLSLFTASSKGDVQTVWDLMRILYTKATLLQTTGLHSSGGPRVRQVAQFSRMTVARVVNVAWTRPNGERAAMVTERGTVHLLDLPSSAFTWPPPRLRSQAQDGKGSMAEGSNSAVSMASNALSSVREVARPLIARPRRSNSNVPQLAGSGIGEYATHGGKVIAASISHSLRKTSSTLNQLRHTGENRVSLPNSASSPGSSCVVWVSGRKNHLLFVLGAGLVRTFPTKSRRAHAGGDRRAPRLSHCRDFKLPSLPDDSLSLYVRSILDPDEFFEFSDKELDAGNNTLNRESLQAASISSLLTATSLDDVEPVAPRRRPAKGPRLPPTQQLTSIGPSKTQVGAWAFGQPIRASKLDLGLPHVPEEETFNIASDGSRALPPSAMERILHRTGDDDQIVVTTRRRRGAAHSANQDDDGFFEDDCEVIDFADQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZD0</accession>
    <name>A0AAE0JZD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZD0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="390" mass="41813" checksum="A57B060C318E9932" modified="2024-05-29" version="1">MVAARSSAKCPGLIVRPMSRTFAGDVTILYKHALVVLMSSNTSVHATGNGGDSALDSGTRLCCRNTHCDAVKWRLALAATATERGQGASAEADQELPWDRGSVASSPRLNTILDSRDRGREAIPSASNSIPIEHLDSVISNDTALMPAKKPVDRLLRARQTIRFHATGHPNATAISQADLEFARQSVPTFEPEDTEPADEPAHPINWAQTRNSIDAFLGSFRNVSLSDLSIGLEDSLVPSFLRTPTPQFNSKAEAARQFKEFGRPPSPGTTPPPQTPVEYPSPEIVRNTLGNRDRDRSTHKMTGDAPPGPNTPLTNAMAADLIAAALSGTPRWPQASDVGYFDPSAKDKDSSGAGIIADGKVTKYTNVFPFCDLLVHLESTNGADAVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K077</accession>
    <name>A0AAE0K077_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K077"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="118" mass="13912" checksum="C71DBC29F2379269" modified="2024-05-29" version="1">MSDFRLHMLRRHHILAAEAKNSYDEEAFFFERAKRVKKINCIDDSDRFDLRWLWLMETHVQESRTSVLKKKLVADFQLGILLAIIYSLFHTYILSVLKAKDAPLGFGEESIVDDCCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0B0</accession>
    <name>A0AAE0K0B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_535699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0B0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="32442" checksum="3DCBAB9F94908D6B" modified="2024-05-29" version="1">MRKKLGYPYPVPFEDHYRAEISSFRGRDPAQLLFKGFPTVESVTFAKHPNVWVTQNDKGHHVWTRIRNGECLWTSLALSLFGNAEFWLRVKADHLAFLEAILKNLDHPRYEYYTRLNRSKGETLATGIGRATKLKPRNIWDRLHIPGGWNSDEILALTADVYKLENHFQPMIPNDYLAYEFKFPRMTLQLSQKYRLVSHEPTKPENREDGPRHFFRASMRQVSATEPSLARPPTEYQHLRRAMGFLPFPQDFINGPPSQPRQPPNTKQRVQLWKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0I9</accession>
    <name>A0AAE0K0I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotrophy-associated secreted protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041940048" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="99" mass="9564" checksum="81749B142B7A9114" modified="2024-05-29" version="1">MVRISIAAVLAFAVSTLALSPNNAGAKNVGGGNAQQFITGGCVNNADCQSACCANLSGVGICSAEAAAFQAGKAGCNFVDPNAAATIAAAKAQVAKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0J1</accession>
    <name>A0AAE0K0J1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_504561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="119"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="826" mass="92205" checksum="1C014902203F86F7" modified="2024-05-29" version="1">MALQLSCLYRSWWPPRGPSLCKEGHLARAPAHAGTPACIISTTDSIAAMSRIPSTSFGPGNRGQQVGQNYGTINAEFHLLPERPETPPIPFATIPFSRDPDFVDRGDILDQIDKQCSKPAGRVALVGLGGVGKSQLAIEYAHRIAEQQPDKWVFWVHAGTQARVEEGFRTIADVVKLPGRNQPKADIPQLMYSWLSNERNGRWIMILDSADDRDVLYNANRSLSPTSSDAYDRRSFATYLPQSRNGSIIVTTRNRDLAFKLTGRRQNMIDVGPMAQTDALILLEKKLGSPASLDVAADLVKALDLVPLAISQAAAYIQARAPRTSPEKYLAEFRENERKRARLLGYDGGDLRRDGGASNAILTTWQISFDHIRSKRRTAADLLSLMSFFDRQGIPGWVLKPPRATTDTARVQNVDLAGVGESDASGDATDDGIDDDADDDADEALDDGFEDDVVMLRDYCLIAVDVNKDEFEMHGLVQLSTKRWLEASGQLGAFIQQYIERIAASFPTGDYENWATCRKLFAHAQMAVSYQPSEDIIEIWAILLHNGGWYARSQGIYEVAQQMLAKARKVREKRLGKEDVATLASITMFALVLLDRGQWEEAEKLFVQVMETRKTKLGADHPSTLTSMANLASTYRNQGRWEEAEKLFVQVMETSKTKLGADHPSTLTSMANLASTYRNQGRWEEAEKLFVQVMETRKTKLGADHPSTLTSMANLASTYRNQGRWEEAEKLEVQVMETSKTKLGADHPSTLTSMANLASTYRNQGRWEEAEKLEVQVMETRKTKLGADHPSTLKSMANLASTFWNQGRWEEAEKLFVQIKVDMQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K118</accession>
    <name>A0AAE0K118_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_441203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K118"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000673">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="276"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="400" mass="44083" checksum="989489C802BE9709" modified="2024-05-29" version="1">MAHSKRNTSRPIFTSYEREMAKSAWGVSSARLSRESFLPFASCHLCLETAIDPVSCLHGDIFCRECALSNILAQKKEIKRSEKAREQELSETLEDKARKDAEAQARSIQEFELTQAGLEINHSSSSSSRKLKAGPHMPDIEPETPRDPDGGAAAAKRGEKRKFSLDGDEVARIVMEERAKARKAIDDEKSSKPTLPSFWSPSVTPSSNTNNVLHEVKKKLKSQPVCPASQQDSPHFYSLHTLVSVKFTTEEEEEETNSTTSSTTTKKKKSSQQRICPSCKRALSNTSKAMLAKPCGHVLCKSCVDKFMKPPPSGHHHHQHDPHAPLPDSDPEAIRCYVCDADLTERKDNNPKNKKDGGGGGSKAEKERIKPGLVELHHEGTGFSANGANKVKKVGVSFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1H3</accession>
    <name>A0AAE0K1H3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_74611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1H3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="152"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3368313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="592" mass="65165" checksum="DA4C913D7578A66A" modified="2024-05-29" version="1">MNEKDASPYDSAQTGTSPTNNAPPKSISSTGSDDDTPRHGRHLKAVDDGENPNHGDPDIDHDEIEATVPGHELDVELGQKHNLEELKRIETRGSIKSKVSRVLSVVARKKTRERIPFAPIPTSNLDEGIVGWDSQHDPHMPFNFAKSKKWLIVSLLSTATFLTPFASSILAPGIGSLNREFNNTNDIVGTITVSIYLLGYCIGPLFLAPLSEIYGRRPVLAATNVFFCVWQIGCALAPDIEALIVFRFLAGIGGSGCLTLGAGVIADVFRTDERGFAIGIYTLGPLIGPTVGPVIGGFLSQTIGWRWDFWIVFIAGVIVTILTEIFNSETNPRVLIERKVKRLQQELGRDDLRSCYDISTSEPKSQKQILLNGLTRPTKMLFQSPIVFFVSLYIAFTYGVLYLLFTTIPVVFRETYGWSIGITGLIYICLGLGNLSGWGVVTATSDKTVVRLTRANGGVFEPEMRLPISIYFSFCLPITFFWYGWAAQYHTHWIVPVISLFPYSFSIVGIFLPMTTYLVDCYPSYAASAIAANTVLRSLVGMLLPLGGPSMYDNLGLGWGNTLLGFLCIAMIPVPLLIHRFGARLRKRGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1J4</accession>
    <name>A0AAE0K1J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_488322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1J4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="20284" checksum="C6E5C9B6052FFA8B" modified="2024-05-29" version="1">MDRDQNASEDLMERRGRIIADILSTFGQLVRQGTEKVDSTVTIGQTGYSSMALDILMNTLIKLIEDLLGLTRQLRELWIAGPLRLPGAGDDEAESALQQDAATVFSILATLRNQSRQRAAEATRESHGYVTYVSGPVDGPPPPIDPKAVAAAPGTGVLSAEAAALLKPFNVVDTRRAPMSGMVGKGAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1R7</accession>
    <name>A0AAE0K1R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_565152</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042110894" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3368469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="244" mass="26296" checksum="47E36C6C6E20979D" modified="2024-05-29" version="1">MKFTIIATLVASAHAHSIFQKLSINGAEQAQLVGLRAPKEPNPVYNVNDAQLACGIRGTQSDKILSVKAGDKIGAWWGHVMGGAQRPNDPDHPIAASHKGPISTYMARVDNAATASPTGLKWFKIHEDAFNTATGKWGVDNMIANKGWAYANIPTCLAPGQYLLRQELIALHSAYSSMGAQFYQSCAQLNVSSARTFVPSQTVSIPSAYQQNDPSILIQIWVNSVPDNGRKPYQAPGPRPMACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1W0</accession>
    <name>A0AAE0K1W0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1W0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23624" checksum="5CFF693F76CD9971" modified="2024-05-29" version="1">MQLDNNRSKLFDKLEVDTAGSGYYPCKESEHEDEGRDNEVMEYALRAVGLWDDLVVSQGAGFGSPLREEALSRGQRQMFGLARAIMRARWLVRATKGRGSGRGRGNADTNMAMWTVILREFQGYTIVRVAHRLLHITECHDKVIVMGNGRVVQVGSPDELPDKRIASSESRGNCNRQKARRGDRADYICPHQSPCSGATQNMTKGTIKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K300</accession>
    <name>A0AAE0K300_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K300"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="30520" checksum="82E271E76AD7B1B6" modified="2024-05-29" version="1">MSWLTNLATNVIAAAVPDGFDLVALGAHNPFGTPHAARDEDGGRNEAAPRRSIDESDPESWYLGGDESETMNDRKKLIEFRKQACEQNNSEEDDDDDLCGDTGEAPFEAQAFGNKVFEIVSIEIARPRHFTRFITGWKPIGRMETFCKTLERVDRGSGSEMPTVPWQAGVHYLRNVQAWDELHSNPQKKETQALVKTAWDIIVIDSEASDIWNWEQVYTNDKEVLAELWPTIVQVVRLYYDTHFDARKRCPVCTLKAPEDYVPWVLGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K3A7</accession>
    <name>A0AAE0K3A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_489023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K3A7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042200987" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="173" mass="19356" checksum="5C14946AF4309B61" modified="2024-05-29" version="1">MHLLPLLAAGILAPATVLAAPSWLWPRDAALSTRENLCSLKSPPQLCTPNASVTVEETALRAYKFYRAFVVDGDPRTMFSLMDSSYIQHHAGYSSGPQAIWSLFCNGRKIGSESSTAWCFDAATNMSYAQYSTTDRWRWVDGCVHEHWDQNEKIPKDKCYKLPTSTKPSTIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4Z8</accession>
    <name>A0AAE0K4Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_564410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4Z8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="33656" checksum="D56DDF5D3C09E86D" modified="2024-05-29" version="1">MDQDQARHLGPAVPSLGYLFNRETDLFGKAAGFSAPYLASGKMEWDEGGSGSGLIAIIQDFFGIKSVDDAMRGVGIFFAPSCLGVTFWTVLAQLASSLGPRLQKFLPRRFWLQNITRYLLPILLVFRTGPVLAMYLSPEADTRHRWSWEWQLAPLWFGIANFVAAHTIAPSPNKLSSSSSAAVATSSRGLLAVLGLISASVWGYTLLSAPYSMSEIFLPKGPQDSFVPHTRRSLQLDHLFSFGPSFLWLMYQHGDMYSTNLVAAVDVLWLVATFPVVVALAGTGPAFSVGWLWRESLFSIRTANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6E2</accession>
    <name>A0AAE0K6E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_486326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6E2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="36241" checksum="FDC2FD1E08BE7578" modified="2024-05-29" version="1">MSSAQNKRKAPGGGLGLLQRRVRPRVEREPNSESDADSQAPSEEGVDSQGSGSDDEEDDEVDDSGSEEESGDEESEDEASPSVDASQLSFGALARAQAALGAASRRKGAAKEESITSKDGGAASKDESSYLQRQAEREEKKKKQLLKRASKHAPAEMTSKKAVSRRRDFVTVPTAQPRDPRFGPLVGAPVDEVKLRKAYSFLDDYLEDEMKQLREAIKKTGKKDPVAKEKLQRALMVMESKKKTQVRKDRERHVIEEHRRQEKELVAQGKQPFYLKKAEQKKRVLIDQFSGLKKGQVDHAIERKRKKVASKEKKLLPYARRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8G8</accession>
    <name>A0AAE0K8G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_439249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042117096" description="Cellobiose dehydrogenase-like cytochrome domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="3">
        <location>
            <begin position="38"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="391" mass="40346" checksum="A7DF98E820DE5BF0" modified="2024-05-29" version="1">MISPRSLALLALGSTQIWTASASEGVEPAKRQDAARKYCPGGTSICFSEYTVATHNIVYRIAIPDVKSAPFDILLQIVAPVAVGWAGLAWGGKMSSNPLTVAWANGKTSVVSSRFTTGHSTPGAYAGATYTVLPSTTANATHWELDVLCRGCSQWSGGSLDPNGVNALAWAKSSKAVTAASNNASAFSIHDAKAVFAHDFSAAKIPQGVFDALAYELSKPAPSSAPPAASSTAVVLTSVVTLPIPTPSVVVTPPGPTVISTRLTALPPAQSSMLSKPPVVVSTRVTQLPPKPETSTVLVIPDPPKPSTPPVVISTRITQLPPKPLTSTVYVLPTTPAIVTVTVTRATPPAVTTVVPAPAVTPPWVGGPPWRGGGRPPWRGGRPWGTGEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8T8</accession>
    <name>A0AAE0K8T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8T8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041954436" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14800" checksum="5F9B84F4DC9EADCF" modified="2024-05-29" version="1">MKLTAILSLSGALALGVSASVLPPRQLEGTPRPGLLSIIALYTGDQCDNQSRWWAISTGAENPYLQSKKGCLMVDPTWNITSAKIVYSGEACTVSFYTDASCQDEAVTPELDECSTVSEANWKSYSIRGCTDLVEAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA17</accession>
    <name>A0AAE0KA17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_527138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA17"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="45902" checksum="D96D1CDFFBD821E1" modified="2024-05-29" version="1">MSYNTTSQNAPSPSVAYATGIGGAGVNIVTATWISWVLALFSVGLRFYTRTRLMHVLGASDWVLAGSLVAALGLCISKTNECAHGMGRHVWDIDFMAERKSLLQGFWFTVVTYQLTLALTKVSICLLYLKIFVYPWALRACRVLLGIVTLSSLWCIVTLLTACIPLQAFWDSSVKGSFCHKPPVWWGVTGVPVFTDVLVCIFPIPMVIRLTLPRRQKILVVGVFTGGFLVCLVSLIRLAITIQSARNPSNDMTYYNVPVTFSIIIEVHTAIAVASIMTLKPLIAKFFPSLLDQQNVESSNSYISGTDSPPTIGSKPSRNDAGDAPRPNSRVDSLSSITVTGAIEANLEAQLQKQQPAEAPSPRAHENEGNIPDKTENKSPVVTVTVTRSQTSPVPTVDEGLGSPGATRVFAMMAPRENGQIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDN9</accession>
    <name>A0AAE0KDN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_502867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDN9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090196" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="272" mass="27837" checksum="0963F387AFCC1787" modified="2024-05-29" version="1">MRAVSALPVFAAAVAAQATAGAYGQCGGTGYVGPSACGSGYTCTTYNPYYAQCYPGTAAATPTPTPSTASTASKSSATTSSSVSSKTGTTLSTVITTSTTTSKAATSSTTTAAGSGSTPTTLQSGWYWVRAVAAPNFHGYLQAATGSSLPSALITTASSAGQFNIISGQLVWNRFPTGSAPYYLQVENVADKTQRTLKTWFAETKNTYGTFAFQGDTLAWTTTDIARPNSAAWLVCGDTKELFINTGAYLYNTPAGCADQTIHSYGGATADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KET9</accession>
    <name>A0AAE0KET9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_255392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KET9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042146206" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9824" checksum="EFA75C0FFA225801" modified="2024-05-29" version="1">MPMNQGSILLWLSWRALLPEGWLASDQCRRMLHPPGRLAPAPDFVLGSRVAGKSAVITDRGSGRRRVSCSLQTRLEMAGTGTDHIHDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEW9</accession>
    <name>A0AAE0KEW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_261113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEW9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042156193" evidence="9">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3374935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="43893" checksum="B81AA6F943ADDF0E" modified="2024-05-29" version="1">MGGLLILLALSVVMALASFLAGALPLSMTLSQSQLRLISSIGIGILVGTSLIVIIPEGIEAIATTGAAGHSHNARHLSRGCNLGVRWEAGINVANGNGEALKLPRWEGVDIASRAIHSIFSTMPRAEKDDEENEGSVPNDGKNNHAKTLPANSPEDKDDHDVPRLPTFYIGFSLTLGFVLMFLIDRLPRHATDTFQAAPATRHISLDNLSTSSVLSQDEEAEGFLGSLAPSPKQSRSLATTTGLVIHAAADGIAMGASATTSNMKLGLIIFVAIMVHKAPAAFGLTSLLLKQGLSKRAARGHLIVFSLAAPFGALMTYLIISLLGGDHMEGESGQWWTGMLLLFSAGTFLYVAMHAMQEENHSQPHDHHSTMNGYPSSTMDQRKQSKPQIRDTLATVGGMLLPLLTQFGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF57</accession>
    <name>A0AAE0KF57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_453155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF57"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042243033" evidence="1">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="43"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="41339" checksum="512F8BE6FCD0377D" modified="2024-05-29" version="1">MVVVPPILPLLLSTLALADCECGYSLSTTGPSSSSTYVFTDLVESNFACLHDISKNTDWVRQEFNLSKSRARGEYGEMFAVDNVATNPMQIDNADSGRLGAEGSEDSAGLQLIVRRELVEEMVPVAEIDTHRLDMFWGSFRASMRMTNVSGTCAAFFWYFNDTQEIDIEFLSKDFNTTNSSYPVNLVLQSREAMQAGFNAALTSNFVKAYLPFNPAAAFHEYRIDYVPGRVFFYADGALLAKMDGPAVPTSPGHLILQHWSNGNPLWTGGPPAQDTVLTVRYVKAYFNSSTPERNRDWASRCKNPAAAEAVCRIPDLTAANLSAASWFFSEHGNMTNNQTVYQESGASRQEFLWPKLWKLVGVLMAWGCLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFI0</accession>
    <name>A0AAE0KFI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_273340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFI0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="74" mass="8460" checksum="F4014EEC8703580B" modified="2024-05-29" version="1">MEFYSVLFDQECMHCPVVYARDRQSFNGTYVNGQLVGKKPNISQARLLQHRDIVTIALHVTMLFSQALAARPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJQ0</accession>
    <name>A0AAE0KJQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TOM7 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_478634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJQ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="53" mass="6188" checksum="FFE00CFA651F9A9C" modified="2024-05-29" version="1">MITLSEESKERISRIIEVSRVAIHYGYLPLILYLGYTRSEPRPYLIHLLSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJT8</accession>
    <name>A0AAE0KJT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_435754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJT8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3377560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="199" mass="21317" checksum="5D4ADFB2B8187023" modified="2024-05-29" version="1">MASSLKITEEEIDDLLYSARAGETEDLSTLLAALADREKVSPAEILASAKDEGKSTCLHMATGNGHTEIVKIIISHFTNQPKETKQAFFDAPNEYGNTGLHWAALGGHLDVVKLLVEEGGATPALANDKNYVPLDLAYQAEKLDVANYFLEKAGMLEGQNGDEALGNAVADVKLDEEDGDRDEGEEVVEASIAEGEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJU5</accession>
    <name>A0AAE0KJU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_478411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJU5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3377946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="490" mass="54883" checksum="14387D097DE62AA8" modified="2024-05-29" version="1">MATSANAEALNESPIPEAIAPKQNKQTIDPYNVTGEIGADGIAKAIDYSKLVEEFGTKKIDQALLERFERVTGKKPHRFLRRGIVFSHRDFELILDRYERGEPFFLYTGRGPSSDSVHIGHTIPFEFTKWLQETFSCPLVIMMTDDEKYLFSEKRTIEEVQGYCRSNAMDIVAVGFDPEKTFIFSDFEFVGGAFYRNIVRMSKMITLNQARNIFGFNESTNIGRIHFGAIQGATSFASSFPHIFGTDEDKTNLIPALIPCAIDQDPYFRMTRDVASRMYTSKGQHVAKPSLIHSRFLDALQGPGTKMSASVDESAIFMMDTPNQIKNKINKYAFSGGKVSQEEHRALGGDTSVDVSFQYLRFFLEDDVELEKIRVSYEAGELLTGELKAICIRELQTYVAGFQERRAKVDEETVSLFMSTRPLKWTGNPRAPIVVPQIEGAADGAGGEAKQGDGKLTKNQLKKLEKLKQIEAKKAQKAKEKEAQAPPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK24</accession>
    <name>A0AAE0KK24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_223147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK24"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="583"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="946" mass="108788" checksum="E69CBDCF7949C225" modified="2024-05-29" version="1">MPEGTVYRETRSYRERDTSPSDDEGYKKTTVRRYKVAPNRVERVEREIDVIEEDRRSRYAPPGFTAGRSSQADLLEVDRHTERVYIPERPRSAFDPSPRSTTYERQVIEREREPRDDDYYTRVDRVEYRDDRPRATVVERERIVDDRVEYRDDRPRGTVVERERIVERDDRDAYPERSRTVVERQVLERERDDDYYRGGDRGRVVYESSKEVERVDRNDTPFSPRSPYDVDRRSYWGDEKETDVRVEKRVERRGDGAEVRIERRVEERRGDGRDDGADVERWRKETEYYESPRDLAPIVIRQRAPEQRIIVQEAPAPPPVVVMREQEAREVTVGHRPSRDEEYYYHRESREVGPYRGERREEEVAIERYDDGRRHHHHHHRHHHGAHSDAESDDGYYVKRTVTRRERSESGSPHKKRHIAEGALAGAGISAILASRRNKEGELPERRGRKVIAGAALGALGTEVVRRAHSAYQERYGDEDHGRSRSRSRPAHSRIKTGLGIAAVALAAAGAAKYYQSQKIEKEEASRGRARNRYSDDEGSRSPGRSKSRARSMATAGVAAAAATGLVQHLRHKSKSRDGKKERSQSRLRTAAEMLAAGAVGAGAKNVWDRHKEKKEREKEIEKEGDARERELSDDDYDDNYHHHGGRSRSLSRSGPTHLDANTTLADPELGLVEYGAQPLPPYRAPPYGDWDDQEEGYESASGDRHRHRKGKGHARSRGDDYSDSEASESDKKAKKKRSSSRIRDLAAGAAAAGAAAIGIKKYTDKKEKDKEEKEKDRERKERNRERDRDRERDRERDREREIDRERDRERQREREREMGKERDRRRYGDETYDAEPSTGRFNRTPSPPNASGGFYTPPTPQNGFTQHPNIAATNLPQQFQPYPQPYNPQNFAPYPPPPPGPPPNSAATTGAVPPGNVPLQAMPPPHIPPPGMTGPTTPTGPEHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKD8</accession>
    <name>A0AAE0KKD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_451882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="165" mass="18623" checksum="636A4E717FE37645" modified="2024-05-29" version="1">MHAFLYRDNASGQGRMVRGSKVGGEFGGSILRDKAKSHHPQKNQAIGSYIIGVFISQAIMSSSSSMNKYWIPHLDIHKKVITQELQYYLGPQATEQIDDICVKSKEMWERQAAARGSGSGDKALKRPLHRPVVISKAGASDSPRRRSDDRWRNESRSRQSERRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKG8</accession>
    <name>A0AAE0KKG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_451415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKG8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="31749" checksum="B6C5E62E2251BA24" modified="2024-05-29" version="1">MAEASEMLSRRVKLANGLSMPQIQLGLYMMSGGETTRAVRSALAAGYRGFDSAQWYNNERESGAAILDFLSRSPNGLTREDVHFTSKLRTNSTSYDTVRASIRKSVDTCKLGYIDLFLLHSPYGGREARLTSWRALEDAVKDGEVKMAGVSNYGVKHIEELMASNPRVTPVVNQIEVHPFNTQTAIREACEKHGIVIEAYAPLARAMRFKNPTVVKLAKKYACSPAQLMVRWSIQHGFVTLPKSTREDRLVANANVGGFEISEEDMQAMDGLDEQLVTDWDPTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKQ9</accession>
    <name>A0AAE0KKQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_451831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKQ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="164" mass="18022" checksum="D860A162E4060D5C" modified="2024-05-29" version="1">MFSRSILSRQLFRQAAPAAVATAPAFRSSILLQHQRRLLSDQTKQAITKAVASAPVVLFMKGTPETPQCGFSRASIQILGLQGVDPNKFAAFNVLEDPELRQGIKEFSDWPTIPQLYVDKEFVGGCDIIMSMHQNGDLAKLLDEKKVLAAGEETSEAESSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKT3</accession>
    <name>A0AAE0KKT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_547745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKT3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="284" mass="32401" checksum="87E99CA5586BDADB" modified="2024-05-29" version="1">MAAFKAAVDIGAHAVETDLHLSKDGVVVLSHDATLKRCFGKEEKIADCDWSYLSTLETLLEPRQGLPRLSDLLEYLAQPGLESVWVLLDIKTDDPAEDLLSATAQTLASVPTARPWNQRIVLGGWNENYIQLCREYLPTFPVAYIGFSLVYARRFLKQPGVNFNLLQQMLVGPVGAQFMKKVRKAQRSLFVWTVNSEAWMEWSIRKQVDGVITDDPKLFLEVCERWKTEGRGRARKTVKMYAIAFFWQVVATVFIVLHYRWLNSRGKRRDVPVGIGRQEVLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2J8</accession>
    <name>A0AAE0N2J8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_488703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2J8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32338" checksum="1D19103A37AAFC6D" modified="2024-05-29" version="1">MGAIDNSANDMEDQHPLLRNENHDGSSAVARLLREEVRAVVREEFLATASASSHQAAPAPASESEPAPPSYDSSARLLADEHVELQATDAARLLGTDVSEDNAAGSEKTWIQHLPIWFRVVLGIIPFLGVFGSVIAISASGRDKLGLAMAAFFLVIAMWGVTFMFAVFSSFVPETASKKPNNTTTSDAAAQEEASTSPSTPPSPTRAKQQDNFFFTTVLSWHFFIMYMAFGLLLWGWFLGQARAPFARVELAARFDAKFRTHDALSRLTTCLWDDLPKRNATSKDVTACLKTMGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3A0</accession>
    <name>A0AAE0N3A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_515196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3A0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005412" evidence="2">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="332" mass="35890" checksum="8EE12E90F93B74ED" modified="2024-05-29" version="1">MKFFTTILAAAAVGSSMAAPAAEAKSTLTIHRHWHDYLEQLNSHVLHHHVYDHHNYHHDHNYRHHHQRRHQDHYRHRHCEGQRFCRWWIFRRLFGRLVCSFVTTVKAASSSALAHPSSAPKDKAAATNYDSRVATISKQADTVKNQLIVINKAVQANEKPTVTASLTVTLESELSVLLTDVTYLVQDLLVVVEDVLNIVLNLLASVLNILSAVVVELEFTLGLVIEEVAYIVVPTLTGGVDVILNTILNGLGGSISTSGNTTTVSGLSSLVSSLTGALTGVLSGSTSSSSTTTTTTTATDTSTQTTQIEAQLSVIQQTVIAISQGDAVVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N414</accession>
    <name>A0AAE0N414_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_515195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N414"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="49004" checksum="C337A27E93F01A73" modified="2024-05-29" version="1">MAETKPPGLQITIIGAGIAGLGAAIALKKHPAIDVQIYERAAELQEIGASIALGPNGMRTLERLGVNNALDESVAFRNKSGFPMIYRHYQTNEVVSVDTHRGHVDPLHHTARFYRAHLQQALLKHVDLAQIHLSKSFRSVAARNSEGKLIITFHDGTTATTDILLGADGIRSRVRTFLVPTSATAWTGWVAFRSVFPISHVAHISGLPDEATHFWGPNGRTLFTSPLGKDLFTVVASHQSDPSAADAPYSDAVWDEDGDVSVFREFYQDWSPLAQAIVAATPHTSVYPNAAARGLDTWVLSLPGDSKGGRVTLAGDAAHAHGGAFAAGGSLALDDAWAFAAAVMHVFPPGSARKPTEEDVGFALRLYEATRKKHTDKVIRAVHEGNGEKVAKALRETETDEALRERMKSRGDPAWIHEHDVLGEFQRALGELKGENDAVKVVDVVVVGGEQVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N431</accession>
    <name>A0AAE0N431_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helix-turn-helix-domain containing protein type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_80189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N431"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18856" checksum="D17CC27BD04A5EA4" modified="2024-05-29" version="1">MATLTLAYVVIPTFTSGLNTLSHILSVAEAHAKANGLDADAEYPSASLTEDMRPLSFQVQNATSTVRRTLARLTGTPEPVWEDKEVTLADLRARIAKAHALLKEADAAAVNARAEQTVDLPLGPTAVIKLSAQDSALKQGIPNFFFHLQTAYAILRLKGVPIGKKDYITSFLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5Y0</accession>
    <name>A0AAE0N5Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_286471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5Y0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="25670" checksum="52A4E212989196B0" modified="2024-05-29" version="1">MMHPSRIEGPSPPYGIVPNRLGACRRGPAAANHRTCFNLGPSSFSGCAGVYFDVVLVTGTRGQLFRYRVGRSAAQCRRVDAIAALHWETTGKGVTQGKKNIFQQEAQLQKCAAKACASLRRCLTNFSWPSRRHLLARHSGKLSSGVGTVPFPPQVAYVSYFLPKLSACRCLPWFFSGAQRLTKKIHHSTARAAVDLCGVDLTKTTSARLRGHLSGSFFVFSALFPIPSCWVSHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6M9</accession>
    <name>A0AAE0N6M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_453474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6M9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="112" mass="12405" checksum="E171C673213AA055" modified="2024-05-29" version="1">MAVKLSIHSGFAHAVAQMLAMAPVSVGAAGPKLLSAHPHTVDRLRASGKVTNVENIDIGRRGDERMVRMMHSLRVLCLLRVDERDKKDQSREEPVRMKPLGPTCGHTFIFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7W1</accession>
    <name>A0AAE0N7W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_527516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3669" evidence="3">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="496" mass="55390" checksum="5D0A0B448FC9362E" modified="2024-05-29" version="1">MHSGSDGDGDGSSSGDNWRTAAPRRPPPIPWRERTFRQMGAGACGVIFVPKDGCEGKVIKIAKKPDYFATELSNEWEMHNRIAAQFGKVIFDVRIPQCFYYHRKDYYCFLQHCQASLARGFGPIERFWDPDSKQQALDDLDNKDCLVRVYLGSMEGGKSQSQDQEGAEIFSLRDFEMHLDQMAELDLNIVGMARRIGMSLAMMHWMARADACGVEFVLSSPATLPNLALAVDFNKEPASGPRPPAQMWILDFNQVREITLDDEGVKLAVEAVELNGPSFPKPPMRSGSEPETHFIFGSDTTSGADLDTGEDSLRGMALGILRSYALLMPTELDFILAHEARLFPSDVTWEAWAPLVPYLTFIPDGSVSKRFHFGQLLLSPLNWCIRPLQPLSAESWWFYDGLARLGSTTNLLYQVFIPLIFVFAALPLRALTGLDIAAMQRVFVLCSLVVLGLLAIILLLMLLVPAAVLIAQLVWIFTRQERHTERRTTRGSPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8G8</accession>
    <name>A0AAE0N8G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_512786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249184" evidence="2">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="22548" checksum="95385344628E08E4" modified="2024-05-29" version="1">MVRATPFFILAAAAAIAKHALAVPTATTAEAAAVTKFKDCLAKCFTECDRDVIHMHRDEPHQLKCVARDCITSCTGPLPRIAAPIIVPGWGPQSSWTSGWDAEPSFSKTTIINNYFPPAPAAAAATYPTGTGTAGTGPTGGALMNPTGTTPTGRWRNPFPQPTDSAHAGPVELSAVCGKTPDRVDDAYNMKNYYFFDDMIEVLVHRDLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8Z9</accession>
    <name>A0AAE0N8Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_453009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="511" mass="57914" checksum="FFEF4A4B05635828" modified="2024-05-29" version="1">MVHLYKRIPHDSFRYGLKYDDSGSTNYEINGGPMPSPYFSAQAMDLLVRLLVHPIWNNNLAALRYLPQTAIELRVPGHVLPIAPLQPNEARDRMIQDLPAETRELKLFFLQAQDMKTVIAALEGAKLYGSPKYRTCDDYYAAYRAARSGGKNAEWPPRELYTLKKWKKASILAVKRDWIVARRYWVAGKRPSLNYEPRDVEQDDLLPLHCQAGVLAYTRDQIESLKGTHWPLAKQNPPMEFFDEPDRHSPFSHILEDSGNPQFAPGVIEELCHLTMHAFGSLDVLRELADEERAILHRLRESMPRAEGASPGLVTRVEKLEHYNAELIQFLQKAKASESVPSESTEIQRLKRLLEDKGKELQESRAALSQKLTSPGSLAAVRMDEEFKFFLTSWLGVHASPLARGLIHDMATARAPQEVSEVRDDFWVAEKPWLPIAEVAEPYWESPCELAIRLYLALAGSQDSLTTAALALAILAKLIPLMQKSTYHQVGACYKNIWGVALSLNIEDKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC89</accession>
    <name>A0AAE0NC89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_246569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC89"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44887" checksum="457859B7B09D7B27" modified="2024-05-29" version="1">MERVKPRDDDAETRDEAACRKASGRGVKLGKKHGNKTDAGDKDEVSDAPAKHKKAGSKKHKRSKGGSSVSANSYDAVTNTVLGCYTDEHESSESGSSTQKGANTGSDTGRSTPTNEAAAKPQTGSGNSNWTPSEDARILSMKKGGESWANIGNAISRGKKEVQKRHKELNSENITSPSLVKKFFASSSSSRNKKKDGGASIDTADEGDIYEMTEYHAHRSNFKKKNSSTKLGKACYTSTPEDDDEHKEEYENLIRENQRRLAKLAVNDSDDDGHHHGKGKAKAKLDEDNDHDNGKGKRKGKAKLLLEEEDDEDNDDHHYANNNDNDQQQPQQQQQQQPEPVDVNATQKGCLTNIDVGILRLLNTRNQTHRWLDLQTAFFNNTGRMIDIEVLKWVIEQQQQEAGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC91</accession>
    <name>A0AAE0NC91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_525651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC91"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="82" mass="9471" checksum="3921A2F54871A63F" modified="2024-05-29" version="1">MPQEISDIKKFIEICRRNDASSARIKKNKNTSQIKFKVRCQRHLYTLVLKDTEKAEKLKQSLPPSLAIKDVPKKNKSNKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGF7</accession>
    <name>A0AAE0NGF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_494922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041932275" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="346" mass="37814" checksum="F83D7FE84A27B4FC" modified="2024-05-29" version="1">MKASILAVAAALYAQEAAAQFAQAAMMRFQCSQLVIERLDPLVNPGQLQSTHLHQIVGGNSFNATMTPVEYDPAAKSSCTTCTFAEDFSNYWTANIYFKAKNGSFKRVPQMVNLGLKGQGGVTVYYIPPYDGKTKVTAFKPGFRMLAGDPNLRSQKGMQKQICHRCEHNIAQNPFGGAPCTGDDTAAFPKKPCDGGIRSTITFPTCWDGKNVDSPDHKSHVAYPSSGTFESTGPCPASHPVRLPQVMYEVMWDTREFNDKSMWPETGQPLVYSTGDTTGYGQHGDYVFGWKGDALQKALDARCSGDRCSALKTQTNEETLACFKGQTVKEQTEGWLDSLPGDIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGY5</accession>
    <name>A0AAE0NGY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Longin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_475224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGY5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="197" mass="21150" checksum="4B42ACBADDE15960" modified="2024-05-29" version="1">MATAIPSIACLGVIGRNNNPLHVALFPSFDPATNSFAPVRTPLQFSLLLSSTLDIFELRSRHNAANSVGLSGDFGLLHAVDERLAAYGFETNTGTKFVVIVDMRGRRIDGAVAAGLVDGRGAEKRIGAAAVGLREGEMKPVFKAMQTAYIKLLQNPFFDPDEHSPPAGLGGKKITNKKFADDMRRIGENWTPGVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHT4</accession>
    <name>A0AAE0NHT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_476552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHT4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="348" mass="36522" checksum="494870DEC3702245" modified="2024-05-29" version="1">MASKHLASILPQKGGPLVVAERTTPEPGPGEILIEVKAVALNPIDYHQRDLGMPGVPFYPAVIGLDAAGVVAKAEPGVSGGPSPGTRVAVMAIAFYENGSPDQAAFQKFLIAKQECVVRLPDHISFEQGALVPVAAVTALTAWITVGVPLDAKPYTPEDKQAVLVWGGASSIGTFIIQSARKYGFIVYTTASAHNHAYLKTLGVHAVFDYKSDDVVSQIVAAVKRDGVVLNKAHVAVGDGLQATLDVLKETRGDASVAASVAHSPLLAPNHPTLENTEIKFVAPLFDVAHRRNVMRATFDGWLDAGLKSGSVVPSPRVQLEEGGLDGLNAALDKLRAGVSCAKIVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHU7</accession>
    <name>A0AAE0NHU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_502120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHU7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="36406" checksum="8D5F6AC5A417D842" modified="2024-05-29" version="1">MLRFGCSQVVIERLDPLVNPNMNPSTHMHQIVGGDAFNASMPVADVSKLASCTTCHFDQDFSNYWTANLYFRARNGSYKRIPQIANQFNEGDNAGITIYYTSPGPNLTTAFKPGFRMLTGDPTRRTSEGFGKNMQQCYRCYPETNWGGSPYSPCMDPKWDTDHLPKQACPGGIRSNIIFPLCWDGKNLDSPNHRDHVSHPIGAIPPSFSVVTGKCPASHPVKIPQVMLEVMWDTSAFNDPKDWPVDGSQPLVLSTGDTTGYGQHGDYVFGWEGNTLQTAMDSGCYLRNCSKITAQEPKVKNKCSVPVTVKDDHELDAWLSELPGRGMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI23</accession>
    <name>A0AAE0NI23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_546530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI23"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="401" mass="44967" checksum="3B5D463A79EB972B" modified="2024-05-29" version="1">MSGRHLGEGAVFDVSFIVIALKEIQVGTHQFLQDHPNITDLVGWDWDENGAPVLFTAYAENGTLKEFLNIDSDVTMGQRRMFALDVACGLHALHTADVAHGDAKLANTLIFPDPRAAGKWVVKVSDFSHSVFGISSRRVTTYPGSLLYNAPESYSFGLLAWGFLKNGEPYFDSGWSRSTLQGSDVTDHQTFLYYLRKDELLELANSFLITHFNKTSKYDYLLFGQIFEMTLRDNANRRKDVQAIAIALDYCDSADIAHFSSSLNVSILSISVWDFNPWDNEPWSSKPQFVKDIESLLAGPLQPHHAELHFLLSRSYTEGYGVPPDIVKAANHTFEAASFDSLEASWIIELCRESLFPTPELTNKRMGSSVITELLRSAVKEAREEALAAKYAVDYVDFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNR9</accession>
    <name>A0AAE0NNR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_174412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31416" checksum="7A58A5B654136356" modified="2024-05-29" version="1">MADQLHDEITANYEQFREVLSSVLVERLTASPTSCKPRRRANAKSGSKKPVSQPAAATTTGNENNASREDLFEFIEYIASSTFQSLPVSLQRLSHHTWTSSPHIRAQYTLPLTADQASIILHALDPSVTESLHTYRIAPQSPDSASDTKFFPTVLTGYISTTTTPPPAPSSTKRQITACEICQRDWINLTYHHLIPRMVHAKAVKRGWHRGDELQNVAWLCGACHRFVHGFASHEDLARRYYTVKLLLEEPEIEAFASWVGKLRWKGLGGVRGSRRKRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPK1</accession>
    <name>A0AAE0NPK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_522609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPK1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="124" mass="13273" checksum="DFD2E393A3BB4EB5" modified="2024-05-29" version="1">MTGTASSIIERALALNPEFGALSARTAEVMLALWKAATVVECFSGVFVRFDQCLDGLGHLRQLGSAWCGASANSCSRVSCSNNCGIFLCNTSNHHFRAHCEDIANDMKAARSGCGKRERTGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQL8</accession>
    <name>A0AAE0NQL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_186431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQL8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="DUF7580" evidence="6">
        <location>
            <begin position="169"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="610"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="99919" checksum="AC6C4C2063E19EF3" modified="2024-05-29" version="1">MAPPPASLRGFAIEVIDKFNVLCSDLSNDDPQSAFYKSFKAELLLVQEWLEAQPQQLDSQIAARISKLLVNLERLSKWPPNLKKGGNIGSIPQRLAAKWKPPYPNLSKLLTNPNQAKLCLRHFATHEPQFQQQAFLRILKRLPKRNEVLPLEAVTAASTQPQDLEMVDYTSHARSLYGVLAQHSICSSASEPGHIVPHLRLAACRNPAGTHVTFPIFFLDHPHQPGSNGTCQWQGTRIDVFKKSVSFSDGPSRTSDDTSSYIVEAGSFCNIISNPQNAGVELSLSVADEKLVLRELRLQQSSFHLHMPSVSLSQLLEGRQLSRKMRLLLCYILSRTVWQFYESEWVSREWTKENIHFMFEHRNGVPSGIFVNEPFLSARFGREIDGDKDSPRVHKFPKILALGIILLEIELGVDITKDRPRTCFTADGQLTVNSDLIAADFWFQKKDLWKRQDSLVPVKAAVERCLRPSLFEPCRNDVEAEREVLHKQIVSPLHTLFKVSWGPPDNVDLDPVQVNADTSKSAADPRPSTKISASTGVVKSHLSDELFGFLQAQLARLDIQPSLTLTANSRIAGSAMTVKALGDSQTWFDELDKLNSVLRATRAKSQDYQAIRVAVLDTGITEALSDHIKQYKDFVDHDDETPHDLTGHGTNTARLILKMFNKADLFIARVLDSNKVETSEMGSAAQDLMASAIQHAIASWEVDIIVIPWGFETDHAGIMDQIKRACVARILVFAAASNYSNVRRVTFPGRMQHNVICMFATNATVKHSTFNPSRIAKRYNFAILGEEVSLHQDGDLLSGTSVATAIGAGLAARLLDFSRHPDCREWIHRPEDLKLIEGMSAVFAVMAGGGDDNGYNCIAPWRLLEDLAEGEPRDKKREYICQTISRALRDMNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR59</accession>
    <name>A0AAE0NR59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_394291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR59"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="90"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="261"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="645"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="851" mass="94938" checksum="3B250E3A628002FA" modified="2024-05-29" version="1">MVAVLVLSISAVAKPISRRADCPGYEATNVLQADSYLLADLQLLGNCTLYAKDITNLRLLVEYQTDTRLHVLISDSDNNVFQVPDQVLHRPHSQNSTADTSAIRFTYKKNPFSFTVTRVSTGEVLFDTSAAPLIFETQYVRLRTRLPTNPNLYGLGEHSDDFRLGTTGYTRTLWNAEAPFIPRNQNLYGSHPIYFDHRGSAGTHGVFLLSASGMDIKIDKTEAGEQYLEYNTIGGVLDFYFFAGPEPTAVTKQYADVVGLPAMMPYWTLGFHQCKYGWKTVDFVAEVVAKYAAANIPLETVWGDIDYMGDHKDFSTDPVNYTMDKLQKLISSLHANKQHYVQIVDPGIGQSSSYPTFARGAEQGVFLRSLDGFFYTGYQWAGKVVWPDWFAPNTQAWWTAEIERFYDPTTGIDVEGLWTDMNEASNMCDQSCFNREGNLSHAIPQLVPSIGPMKGLPGRDLLNPGYHIRNRHGGLSVNALWTNISNADGTYQYDTHNLYGTMMARATRSALVERKPTKRPFLLTRSTFAGAGRYAAHWFGDNYSAWDDYRIAIKQMLAFTSMHQMSMVGSDVCGFNGVAQPVMCARWAALGAFQPFYRNHADTSAPEQEFYLWPIVADSARKAINARYRLLDYIYTAMNKHSTYGDPVASPLWFKYPADTNTFDIQTQWFFGDALLVSPVVDDDSTSVTYYLPDDVFYDFWTLKPVRGRGASVTANDVGWSDIPVHIRGGSIVPLRAKSGYTTADVRSQNFTIIVAPGIDGNAQGSMYLDDGESLDVGTQKSEIQFYWDGALFVCNGTFGYPTDVWVEHVTILGGGNNGSALSVGKQGGIPGGFGPWRLNRSFFVFRHSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTU1</accession>
    <name>A0AAE0NTU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_470488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="501" mass="55698" checksum="DA6EC3A349A20EE9" modified="2024-05-29" version="1">MMTIPRAIVVAACPDGLDFEQVQILVRHGERTPIQPRFQNTGLSPHWPYCSAAQRFSQAVMSAQDGSKWETMPWKRRLETSGPDGQSIPAQGPGGETSSNMCMPGELTDKGRETTLAFGKWLRRVYVDQLCLLPKHLNDAKMVYARTTEIPRVVESVQQILHGLYPSGTNQTGTPWDIAVRSRADETLLPSKRHCARLAELARDFSQAAATKWNESDDMNYLSKKLGKWMPSNKALTVDSQPPLSAVMDSINATLAHGPDTRLPDEFYDERVRKAIDHIVLSEKFGGYGVSRELRMLGTGQLMGGIVLKMVDQAEWNRRQPMSQSPNAQSNAPPRLSLLGCHDTTIGRVLASLGCLDGCEKWPPFTSHISFELFRKKRAPSPKGDDIGGRWLWKSATTSLLSSQRDAGRPCENERRVAKQLMTQETQGLEEYFVRVVYNDRIMTIPGCRAEGKHLDGDTSICTLSAFKSIIDKFTPVNWIYACNSNLGALSATRGNEPAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTU6</accession>
    <name>A0AAE0NTU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_431569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTU6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="26661" checksum="76BA8DAC09541B05" modified="2024-05-29" version="1">MFRQTISTPSRAIGSSLRLAAQRQVARPQFYRAPAAATGAIALRPRFYSSEAETKEGEVKDASATEANDAEAALKKQLEAKDAEARDWKDKYLRSVADFRNLQERTAREMKSTRDFAIQKFAKDLVDSVDNFDRALTMVPNEKLNAEEKNEDIRDLVNLYEGLKMTENILMETLKRHGLERFDPHGEKFNPNEHEATFMTPMADKDNNVVILTQQKGFKLNGRVLRPAKVGVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTV3</accession>
    <name>A0AAE0NTV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Telomere repeat binding factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_160762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTV3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="737"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120549" checksum="C16707A3AE5A4F5C" modified="2024-05-29" version="1">MADPKSALSQSIEADLFAAFAAAEGPIAEHGHTAISALDAPQTTHHDPQPPHNHTLAQASDLKLHQPESFSTAQEFPKRSRSPDLFLECDAKRRKTEQMEEDHSGLKEEAEHGGAPNLDLAAMLNDALASFDAQSTEPSMHDHDAPLHDHNAPLPDHQGHQQHHDTQDHHGHHSHHDAVIHEPDMHGGDINMAMNDPIDTTAVTSAPSATATPGLERATKIMKVSTNSTYMMRSMSLPVLGNLAVQILVRLSSQPRAETELLLSDPDSEFRKAFDILRNTFALVRKMFSDYPLLFPDELDISDSEDRETIRMSNLAATAASVLVDKDVALEDVHDYMLSIFVPEDGEYKDSLTELLVGLKTRVFLDAFKDQPETPHTKLVAKFFPNNFDELLKQRSGDEVLSADEERLVHQLNERTEFLLHATSDESAKVSLESQFSLENFIENMSTFLQGHLSIVVEYAEKYGVNIPLSEDGPGMGQVSDENSPHEDLGLENHTQESQGQDEQRQENQGRENASEENHGQEIGPQEHDDLAALLQSVTAAHLQNGITEDMHTGAHLEEHAASSEDVDGLDLRALLEQSLSNHVDDHVDEPKSEQINHDGSHESTDLFDTKDLASLIAEKLDDLDTPHGLPDMSTSSYSANNHENGVGMAHDSGYSVQGSSSHADVHPQYLAQLNQTHSSPYQPYTQAPPAPPAAATGDNLPPNQSSPTAVLYERARQAAVAKSSNTARREGLHSTRRPWTPEEEKALMTGLDIVKGPHWSQILGIFGANGSHSDILKDRTQVQLKDKARNLKLFFLKTNSEMPYYLQSVTGELKTRAPSQAARKEAEEKARMNLEEEQARIQGIMTLAGGLQNNHHPATSSPLATSSPARVNPIAPAAQGAANSGSQTQATSASGLPHVAISPMVKSEPTDYHSLSHVNKLPQIQPALAPAPPTPIALKPQPQPHHPSQHQSNHHQQQQAHQPQHSHQQQQQQQHQHHLQQHHQHQQSQQNQHHQQQQQQPQQQQQSQLHQPPPQSQSQYHGAQTSPQSQAHKQTQNNQIQNYELPPIPPNHHSTPEQVQDKELYETLQALIAEPSANDRHEPETSEGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU97</accession>
    <name>A0AAE0NU97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_493842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU97"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="391" mass="41327" checksum="F5AC0A680F87C8CF" modified="2024-05-29" version="1">MGDDKNALPGVGGEEVLEQWQQDSIKEAFRPIVHLLERLSFDAVDLLKNNTVTVEEYARSLLGRIKERDSIVKASVYLDEGLTIKQAQALDQNPHGQPGPLHRIAVGVKDVINTKDMPTQFGSPLYQGHQSGFDSSAVAILRAAGALIFGKTTTTEFTVTNSGPDTANPHDPSQTPGGSSCGSAAAVADFQVPISLGAQTGGSLIRPASQKTFSPTFDTFGFIASSMQDLQLPADVFGLQDDEPPASKIALEKATVTLIKTPPWHRAGPGTVVAMEKAVTILEEQGIKIEEVSSPPASFALDGFASMRALADDLAAKYFVIITPSAEQELTYSALPQVLHMPVINVPAFVGSHGMPIGISLVAGRFHDQHLIGTGKVLGEFCMAGGSGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUK6</accession>
    <name>A0AAE0NUK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3388023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="443" mass="48726" checksum="4790D141B2177AB8" modified="2024-05-29" version="1">MAFGVVRLAVRTAIRTVSDFDGVVAGLPTPLQKRVEDYTQRDATGDEEKLKEALQSLFQPIPIAIFSLTLLAFIVISVCMQYAIQQLTWNLTVVEADLDSENSSISLSTSPPPPPYDHKSAGIIEKDVLDGEDSLENDSLLSNSSSAAERAIPAGYDARTDLVTKNIRSTLKHLRQIGGVKMWMRGFLAFVAWAFFTVVLELVIYCIIGGLTINGSEHSALFFVADLFAGLIASVMTSRIHCAWTHETLRDTSRLENVKWFSLKYVSKEDSKLLILPTMRVELAAAFTFGFPLVATNLVFRPLLEAANNGAGAGNAALACIAVLSSFAVGILATVFVLMPALIARTRLEASLLPEEDDTLVPLDRTFSGKMADVREEQLTRKQFVGRFLSLKGAWATFDKKTLRRSVWLSVKYHFISTVVGMMMIVFVCLEVGLMVAIWGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUL7</accession>
    <name>A0AAE0NUL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_500918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUL7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042293635" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="209" mass="22546" checksum="1099F662C7E7591B" modified="2024-05-29" version="1">MQFSLATLLSLAGLAASHGLVQKPATRQPGDATAAACGKTLVKFYKADNTSYPEALARENPKGLTDGYDPKKCNQYLCKGFQFADNKAGVQSYKAGDVVNLEVYIRIPHKGYANVSVVDTASNTIVGTPLISWADNYASSNKPPADQTKFSIKVPELGGKCTEAGACVIQWYWFGQGQTYESCIDFTTPAPAAEHNHGRRAGIRGQTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXU0</accession>
    <name>A0AAE0NXU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase family bicupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_103028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXU0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041913929" evidence="4">
        <location>
            <begin position="27"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="126"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="306"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="477" mass="53190" checksum="D00AA02516A0A1C8" modified="2024-05-29" version="1">MQLSQLPLSTAGLVLVALSLTTPSLAAPHRDSPFERLRNGLELPEKYLTSNKASVKAAVPPYTPDHRDPLDKAIDAVGDGLDPIPYRNGLGAFVLGPWNKERSRTNPDLVRPPSTDHGNMPNMRWSFADSHIRIEEGGWTRQTTVRELGTSVELAAVNMRLDEGTIRELHWHKEAEWAYVLEGSVRVTALDYDGGNFIGDTNKGDLWYFPSGVPHSLQGLSPNGSEFLLIFDDGRFSEESTFLLTDWLAHTPKSVIAENFHLDPQLLKHLPKGEKYIFQGSGLPGSIDDERPKGKGAKKSKYQFTHKMLDQKPLITSGGAVRVTDSKNFAISKTIAAAHAIIEPGALREMHWHPNADEWSFFLRGRARVTIFAAEGTARTFDYVPGDVGIVPRNMGHFVENIGDEPVEMLEIFRADEFRDFSLFQWLGETPKKLVVDHLFANDPVAGEKFWAKVKEAQKDPITKFAADEEEAEEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY60</accession>
    <name>A0AAE0NY60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_464455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY60"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="168" mass="18542" checksum="9096188814FEC572" modified="2024-05-29" version="1">MTRFYLFIDVQLEVYESASVQTLNLRMIAGLIFSPFSTTKSPKKMHFRSALLAVSALAVAGTTQAAAIGSRIPLMGYFRVSTEPQCPLQVSDFIQLGLPLGPDDTSCRNFYNNTVYSAINVEYFHPQCQLVLFNTFACTDPGTISGTGCWVPQGGIKAYKATCPYRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY86</accession>
    <name>A0AAE0NY86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_537993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY86"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="503" mass="54688" checksum="A8B478381A99BD60" modified="2024-05-29" version="1">MSDEDFSAGGLAGTSGNNGLGHTPGKHRGPRFSWNPSYEASFFRSLCESVELGLREGSTFKSEAWDRAIHALITEHNAYANKGHLINKSDNARKKFRLWRGLREDPEFVYNPQDKTVSASEAAWLRHIEKEPLSKSLKGRPFEHETYYEVLFPDVIGSGGAPKRLTKSSRAVRRGDNPMSGSDDHDAPGTNIIELLTEAAYSHPSPALPPLPLQQQQQQQQQQQQQQQQQQQQQQQQQQHKQQHKPVPPPPAVTSAPALVHQHPRSSSNTLSGTGRGSVVSGSSSNAHPGGRNSITQSSSASSSLPSRSSVASSSASSTLPAHSSAPSTSALTPPEDTTTTTTGPGRKRPQLPDATPSASDPAPPGEKRRRTGPPKPSSPKVAPANSNVSAPPGSMLDGIVMLAEALRGTKARAGWPEQAMDLFFRDFANEDMDLQLKIAEKVLTDENKAMVFCKMTDNLRGHWVKRLRESSAETSAVLFKRLYLYVTPYATASNPSLYNIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYG3</accession>
    <name>A0AAE0NYG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_538156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYG3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="126"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="637" mass="68434" checksum="A3943B6E243BCED7" modified="2024-05-29" version="1">MADELELDAVRSSHRENAGQATGSLTQDTRKEYHASTTDLDSIHVTPPNAPSVSELDEPVRDNTGNKDDEKSPQSSSQAVNSNDEKNPPPSSQAVLPTGEPPSEVPAVEDTPPPYSVYTLWEKRLIVLAASIGAIFSPLTAQIYLPALTVLAQDFHVSDSEINLSVTTYMIFQGITPMFIGGFADTAGRRPAYVICFVIYIAANIGLALCKNYASLLVVRCLQSAGSSTTVALCQAVVADIVTSADRGQFIGITVLPIVIAPSLGPVLGGVLSQVLGWRWIFWFLAILAAVTLGAMLLFFPETCRKIVGDGSIRPHPVYQTFWGLIQDRQRKHRRQKKEADAAATGGLQRAPSTVSSRPPKTEKFQFKTPNLLGSLVLLFQKELGILLAYSSIVFAGFYAIATAMPSQFSQLYGFNEIQVGLMYLPMAGGSIVAAFIVGPTINRNYARHSAKMGLGKKVDKTRQMDLAKFPIEKARLEIGLPLLFLSAAVMVSWGWALQYGAPVAVPCVLLFLMGVGMIGFINAVNVLIVDICPGQAGAAVAANNLTRCLVGALASAVVLPMIDALGAGWAFTIFGVLYLVGAPTMWLVMARGMKWRAQVTKKDEEKARKKKERQDAKSAGVLADSTKGSVSEGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYH5</accession>
    <name>A0AAE0NYH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_499798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYH5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="208" mass="22764" checksum="328A79DF3EDAAC17" modified="2024-05-29" version="1">MQQNPQSRDAWCLSNFYALNHLLNGAIMPSHELLKADITPVTIVEPANMVDWFLDEVRQASRRAKIGLCPLLLLVFFENGQLHKGLGIGRLKEALEPDVSVTLFTTACFSGGWAITPVLNNISTRFGSIFAEAPIAALSSVSSPLLARDVDIPDAAAGEEESNLRPEEPSEEQIATYNEFCRAITNALEDEPGSRSIVEGFEFSAQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYI0</accession>
    <name>A0AAE0NYI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_464315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYI0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="310" mass="31711" checksum="C7A4633F5E6826D2" modified="2024-05-29" version="1">MKGTIVLSLATAASAAASHGHHKLDIRAANSTLPCASGVHMLVARGSTEAPGLGRIGVVAGNVSALVPGSTIEPVDYPATFENYSDSEAKGAAFFTKSIVDYTALCPKTKIVLLGYSQGAQAVMDSLCGNSESGFTVSADLPGIYDEYLAAVLTYGDPSHTVGAPWNFGTSNKTGIFPRLNITACEPYSDQIRGYCDTGDVYCDRGNNSATHGSYFKNYTKEATEWIVAKYTASLAAGNVTIGGGHSDNTTVSVPSSPSSTGASTPASSSSSTPTSASGTPVPTSAVGSMRPSFVAGVSAVILSVMYMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZB5</accession>
    <name>A0AAE0NZB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_107592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZB5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="27968" checksum="2F95A7C5B63D67FB" modified="2024-05-29" version="1">MSVIVVWQVFGVVGLSQRGPSARYYSFERRFRDWPIEPLQPQLSSCAARTLEPAPAASLDYSTSGHSFPILWELPRTTHKPNANRLKPEQAWRHHLLDPSTTLTVLSPSRSVASFVIVIASQPPAPRHSDPIFHSAGKPQRSHRHPLNQTTESSNCPPWKQDKPERAKTSHEQEHRNSILPRYQPFCLSAETVPPTAGITSQRAETQARSRNRVGVEARRGTVSARGKLSWVEAKKEEEGRDLTSAKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZF9</accession>
    <name>A0AAE0NZF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_410479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="859" mass="94022" checksum="AC328CB9621121A4" modified="2024-05-29" version="1">MHLPRSNISKLYLHLQNTRHPLSPPVLVLVALEPDALCACRILTRLLKHDYIPHKIQPVAGYADLERIGRELVNPMMGTRGGAGGLVVCLGVGGMADLGSVLGLEPEGEENTFGGVEVWVADAHRPWNLGNVFGGFPLEPETEGASTYAARAPPGVKGGRIDRTYKPGKGGIIVLDDGDIEDELAKEKDAYLALVDMPEIDDNGEDVGDSDDDESDNDEDDTANVGGTPQPGQKRKSWSDLDGEDSEEDDRPRQRRRSNSSSPITDSPLRPAQRGLLSLQDDAIFSSSDTADPPTAAQPPRISAKTLRRKLLRLRRKNEHILRNYYRLGTSYSEPVSSMMYSLASELGREDNDLLWLAIIGVTSMELYGRSSAGIAVTARSADVRPTSGWLGLRGARIRQLLRDEVRRLNPPDVGSKVLPEATGIIPTTARSPEDTSIRLSPEPKFLLIRHWSLYDSMLHSPYLFSRLKTWSETGLKRLHKLLAKMGVSLVQCKQNYTHMDMMLKRELRTKLLKYASLYNLDELVPTIDTDGKDRGGAKDGWGFVRSWGWRATLSAQDVGVVIGALLEVGKNTTSPELVPGGPSQEELDPNSDQAPTEEWLPRFWDAYDALEDIESLKAGLPTAQFLHKAIFTTGTTILKKKQISHLRAFRMCVVKDSSDAALFNHPGALTKLALWIGEALAEQEKDATGKLAHGGRGTPLVVASLDEKRSVYVVVGTGGGGGPDSAFVDREAAKKRAEAKEAKARSKEEQRRNKEKIRAEKKAAKAAANNDEGDDELDSEGSDISDSESEADSDDEGDNDASQERGYGLNRFGTSFQDVVAETNARVRIDSFEHCVVEVKKEDLGGFLESLSMKAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P079</accession>
    <name>A0AAE0P079_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_129772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P079"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="62904" checksum="D845115147C44E4F" modified="2024-05-29" version="1">MSLLITFLTTLKNFVKLQDGNGLRSWLLIESNVSESYYQLSRELKSGFQNSSAIEKLVDKCLPEEDDVPEGMGSPYPGFNTFIREYLEYWRDVDFNDVVNIHARVSGLLISCANALAHPTYGIMLLQTSMSLSESLSKLVMQLNREPRLLAQIQGGSYGVESGERKSIVELAADIIQKIFTACLTDRSSTRDSVPKGKKVAVYLFANLTLKLLFACDKSRLAVQMFTNLSSSGPLLSLYPASQRVTFLYYLGRFNFDHCHYLRAHWSFEEAYRQCPPRFMKHRRQILTYWIPSSLLMGRFPSQTLLQRPEARGFADIFIPICAAVRTGNFVAFQNAMAQNKDWLWAKGLYLTLLQRLKPLVWRSFTRKTFLLTSQQDDASGQFSSNNRAPALALQDLVTTASYVQRLLEGYLPARPAPRARPAPHINTIFLKAVTNSAAAEGAESNSTLAPPPGGPRQLMPSEGLIFANQKPTIDKVEGIVAGLVYAGLLNGFIARQQRKFAIEGAKKQGGNAVRAGWPNPYGSIMERFREDYEESMSLYETDDGDPPGDFDDVPGWVRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P097</accession>
    <name>A0AAE0P097_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_125610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P097"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="67729" checksum="E083B4260BC1C983" modified="2024-05-29" version="1">MIPSNRSSSTSLGPTARDSDAVRPRNRRLANARNDPESSVVSSPGQSPTRSATPIPAAHVGTVTGRNHSGLEVARGSAARGKSPAAGGTSLLGASWAPSWASVTDFASSLIAGGESERPGSRSGSKTRDPRRQVSHQDIRKNQTNWGPSPPSESRLRLQDVAAGSLTEREAALRTMRTASVLESHEGVNGGLNFTRNFKKRSSDEDLRASSQHNQEQGEHLVYIHHVQSTDTYAGIVLKYRCREDAFRKANGLWSRDNIQIRKWLALPVDACEVKGRPCDGPTSTSTQVDLLAKTPEAEPNPFGRRDNNPKGDDYFAGSANGHSPDQSRTGADDDRPWTHVRWVSIDSYPRPVEIGRVERKALGYFPPRRKKSMHTTSTVSTPRGSVDVPSFAGLGSETGGLESPGSTSSRRPSLLTGRPPISTIALGSSPSNSSLSRVNSGGGEDIKPAWMRRPGGVGSMGRNVRVPGPEKDYFNSWTNKHIPGLNIDKLPSMSIMGSETARFGFGRAAGENPAIVESPFENGRDTTSTSRNQAGTGLDKAAAAIETWLRGAFAKRPPGTPILGPRGRSASHEAGDLIELEDTNSDDGRGYNPFSDPGGLLSSITPGASSSRSTGAETVRGRTMGSAATKSNKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0K0</accession>
    <name>A0AAE0P0K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_130660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0K0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF32">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3391040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="68502" checksum="A6C1A8D743360879" modified="2024-05-29" version="1">MISLEDGHEVLTAVTPHRLASCLKSSDTAEARPCMTSLKSQQPQPSIDMELLIERPSLGRRRERGYPSTRGILISLLSTAPVAMAQNCVSLRGSTACSAFQSASVSVDPFMKGLFSFLNFVTDTTTFDDQLKSYVQTTYVQEKYQQLIGCGGISLTNTTDHYARFTTTVICNAIVQNSITRCSLSSENSRPVCADTCAQFAISETYVVADSNLCSKPNDNAQQQIRADFTNCALPARALSGSNCISGIDNERENCGYGGSTLGLCSYCASGGLNSTDTCCYTSNAEKRCANITLPSITPTIPFTTGPPTGTSSSTGLPLAGAGVEKNNGLSGGALAGIVVGAVLGAALIGLLIFLFFCCRRRRRGSQDGSIFNQPQPARKGASASQVAAPASAPQGYEVLPGGRIARMSALEGHSSDAPSRHGTRDMGVAAAVGGAAAYAAGSRRRGDDHSSSDGFGDSPESDRGTTGVLRPPPTTLRRNGSLSSSSALGGEDPQSPTSAGGMSSPPGMASQQSEQLPFFKDYYSQDDIHPGDRVAVLWAYQPRAADEFSLERGDMLKVVGIWDDGWATGVMVEERAEEWEIRRQAQRDSGVSNTSGRLRDPSPPVSGEIKAFPLVCVCLPEHWRKTIEGDGSTETGSSAHQHTATTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3V0</accession>
    <name>A0AAE0P3V0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3V0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3392702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="493" mass="55604" checksum="F3E6EC44C4D3BFF3" modified="2024-05-29" version="1">MTVKARRVAVIGAGPAGAIATDALVKEQAFDTIRVFDRRPIIGGTWVHTPHLPAAIPSLADLLKGNVDLAVTTPTQFPAETPKSEEVNNHQLRFSDSAQHEHLHSNIIPSIMSYSQEPFPPTLSQRTLTKYGPNAPFRHREVIREWVEEIFVRNEHDRLLELSTTVEKAEKRDGEWILTLRKENPGRDYWWQERFDALVVATGHYNVPWLPDDIPGLLEYGTRFPGRIVHSKHFRGGEQFKGGKVVVVGGSVSAHEIIHEVLPFAQHPVYASLRGDPIPSFGWAPFQHPHISLRKKIERLDPVTGTVHFVDGSSVENVDHIVFATGYTFSLPFIPHVQERIKKVYRRLPGVYQHTFDILDPSLTFVGMLGGGFTFRIYEWQAIAVARHLAGRAKALPPISEQQKWESRRVAARGGGKNYYSIAPDYAAFFEFLREIAGDPAPETTGRVLPKFDPEWLKVWAGMVGPKIRGFEESRRKAEEEEEKAGRPVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P457</accession>
    <name>A0AAE0P457_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_530420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P457"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3392885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="783" mass="85031" checksum="D72F8DD8BE8B0DFF" modified="2024-05-29" version="1">MNEDEKQNKVAILMLTSGSTGNAKAVCLTHKQVLAAVAGKAGHRKLPEGRPLLNWIGLDHVASLIEIHMLALWLGVDQVHVTAADVVSNPMTFLELLGRHKVARSFAPNFFLAKLVSKAANSTESGHGQWDLSSLVFLASGGEANDMNTCVAAAAVLEKHGAPANAIAPGFGMTETCAGCIHNLDCPAYDIAGNDDSNTAAVTSLGKGFRGVEMRIVTTGGHLAKQGEPGHLQVRGPVVSVGYYNNLEATDASFTPDGWFRTGDQGAIDGQGSLRLMGRTKDVVNINGVKLVTDDIKTVLEQAILHGYGVAWLMVFPSKAAHTEQVTIAYMPKDEDNYTDLEMAVIDELLAQATMSATGSRPFVFAIRSQSRPLVLATALGKISRAKMRTLFEASAFENDVKAFGGALARAKTIITTESPAASEDEKSITAEFADELLVSGDHFGINTSVFDLGFTSMHLIRLKNRIDARFNMSVPISTLIRHPTAKSLAKALFGSQTSTKSDVGYDPVVTFRASGSETPLWLIHPGVGEVLVFVGLAHHLSDNNRPILALRARGFEEGQSVFSSIAEAVDLYIAAIRKRQPNGPYALCGYSYGTMLAFEVAKRLRADFGEEVPFLGNFNLPPHIKARMRRLSWNMCLLNLAYFLGLTTEEYAETVDEATYRDYNRERALAEVLCVADVDRLQELGLGLLRWTDVAYGLQSMAVDYEPTGLVDSIDIFYAIPLRWAAKSRAEWVSDHLSRWADFSRSPPRFHDVAGAHYTMLGPDHVVGFSQTLKASLRARGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P523</accession>
    <name>A0AAE0P523_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_362194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P523"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="1">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="204" mass="22977" checksum="386861A9DF85679F" modified="2024-05-29" version="1" fragment="single">RSPSYCTGTRYNQSQEDTYVCGDNRLGPVVLPTYLEPLGSVVELYERFGGLCPGEFLTKHWNDSHVDARTHQVSPSYEYPAYGGFSLDANGHPIQANFTLEKDTYIDRFGSEGGNYTSPFGSPYIQRALPPNSLNTYPNGHAFNYYVYRVVKSFVVLSGPIAPWFEQPGQGVQYELYHPIYQLLNTTEGGPYLERVQNPETLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P536</accession>
    <name>A0AAE0P536_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_21874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P536"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042229210" evidence="1">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="476" mass="43418" checksum="603DC67B4F696552" modified="2024-05-29" version="1">MHLSTNAFVAVLLAAIAQNAAAVPQTSAAAPSLLPLPGLQAANQQTGALKPLPGLATASPAAAAPAAAPPVAAPVAAAPVAAPVAARPVQAPAIAAPAAVNQASVSLQPLPGLNAAPQGSLLPLPGLASSPAAVVTAAPPAAVASPPAAIAAPPAAVAAPPAAIASFTPIAAPAATAAASVAAPVAGGLTPIAAASSVAAVVAVTSPAVVIGSFTKIVADTASAAAVTSAAASVASLSSLPAAVATSAAAGVIGSFTPIAAVGAASSLAQLPSVAAAVSAVSAASLAPLPSLTAASPTPAFAFTNGTSVQGVAGVGGVASGSLAPLGTGVAATGTLKALPGLSAASTGSLASLETLPGTAGLSAISSGLSGVVPSATALSGIVSTPVDTSLASLPTEALNSVSLSLTTLTTVTNGVTSTRITAVSVAQTGIPQANSLNGTSSNSAANALPTSGAESMSAVVAVVAGAAGVFAMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P575</accession>
    <name>A0AAE0P575_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_443710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P575"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042253171" evidence="2">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="15073" checksum="00F295CD238EBF07" modified="2024-05-29" version="1">MAAAAALFLCTAIGECAHRSSAFTMLDADFEQIRKLQTERNVASAAKKGSRSFDPATQRGDSSTKAKLGEAWDKELYERHAAGSWPLSSIWVQSAALDDIIWTPSLPPYRLAPEGWVASTATKQHETFIGDDDFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6R4</accession>
    <name>A0AAE0P6R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_43053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6R4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="20972" checksum="FC74A28D605D33DD" modified="2024-05-29" version="1">MAPTGGRDDNDDDNPWSKKHSLERRTSPPSLTRQRTQGQAVDDTRTAQGAPRSVATNYSERFGRQLAEAVVRREPYPQGPRLSIPAYKALFNSAFGNPRGAHFVIQQYDHPNDGAHYALRLQINPTSSVCWAIKFGLPGNPDSVRPSRPAIESRVHPLRHHLAETASESGGSLLMWILALILCYLQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7M6</accession>
    <name>A0AAE0P7M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_57950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7M6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="469" mass="50614" checksum="7C2BA64491B4A9C2" modified="2024-05-29" version="1">MMLRPYPAHAGPRLCQVWELVTKRQPTHSAKRSFVTLHTNTRPLSARTAQENPARPIATRLLTTSKPYLKVKRPASLKSSQGGDQSLQSPQSPQSPQSHNTAPSRFTTTVRSPETPERLASQPSTADLAQLAAAVDRVSRAFLAQQGIPSELTTLTALRACARFDVKVALDVQTTVETHAENPASLLLASSSRQAAERNARTPGNDVQALSSLRLEDVVSKISDAAYAIVSHPAVVITPQVLDEYVSLQARLGRPETLPQVLELFAAKPSPRLVSGSLRFTERNPHKSDSAIPPSIAEATLAAAMEAKDLDAALGIVENTYATKAFLRSKLIKKALLPAAGVGAVPVAAWLVAQNLALLQDSIDQSQATGIAFAGLIAYLGFTATIGVVAATTANDQMKRVTWAPGTPLSQRWLREEERSAMDKIACAFGFSEESRFGEEQGQDFLLLREYILRKGMELDVVNLMPGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV44</accession>
    <name>A0AAE0TV44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_450208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV44"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041939911" evidence="2">
        <location>
            <begin position="27"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="402" mass="44685" checksum="EFDF9033F826B7E9" modified="2024-05-29" version="1">MGPLKFPQTSPMIFLLNLFLVSLVSAAPRPQHTQETGPDPAASQGVGPVQTQPSAPDFVPQKYMAFGDSFAAGIGAGSELGFVHFDNCHRYNGGYPFRLNELIYGHSMPEDNLKACTGATAEEVKAQAQFLDESVDLATISVGGNNVFFSGIVQACVYRFKGSLDGDCDSAIKRSEEAIDNTLGPAVKDALQAFFNRPLNPKIRFFVTGYAKFFNADTPQCDEVSWNYWDLSSPEGGADKMDKNRRRQLNNLVEKVNSKLQEVVLSFGTSMSNKLHFVNYDASFKTRRFCEERFTEPQKKGEERLDLFMHQYYTPDGQLDDNYDSGNITQWTKDLTGGMNAFVKAHPNAKVAKPYADSPIVVNDFPFPRIPSGVKKIFHPTQAGHRAIAQNVFDMWRDNSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVS7</accession>
    <name>A0AAE0TVS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_201750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVS7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3381366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="232" mass="25512" checksum="EDA504E202C05B4D" modified="2024-05-29" version="1">MSITTTTTPPFSFPREYSFPPFFTRQTNLTTHHAQLTKWASLVLAYCRHHRIFKLTLSGIPVTSSSSSASANEPTTITTTSTTPQQQKNELFHNSKINRRLSLADAREVFDFLRKDGRAEYILSNNKDSSFSAAPEGGIGGVGGGGGGGGDVVWVYWRTPEEWAALIEAWVEQTGQKGSVLTLYELTEGDTTCGTEFHGLDPDLLQKALSILVKRAKAQIFGQEDSQGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVX2</accession>
    <name>A0AAE0TVX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YT521-B-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_206539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVX2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="588"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="797" mass="87330" checksum="869FB75D35C8083F" modified="2024-05-29" version="1">MSLDARASELREKLRRSLSQSQARRNSGSPALGNPTSTNPPILSRPGSSGASPALGKPSAALFVPHVVPQKPSQTSLPADANDIAALITSISSTANDQPPPTLSTARPASASNDDAPNNSISREVPKPRVEPQQPLQTGSQRVHEVTKQLPSQPSNKVPKLPSPREDGEVTASPQRMEKSYGHGHARNNSSASSSASVAKADPFTIPTGPRRQSSSHSITAPNSEMIPQSPTSKSGSYLNENRNGRDSVMARPPTHASKTSDGQRPSKVHTNSTNGAKRGDETAQTKNQATNSVPMTPSDALARALELNPDLQDWLVLTDYYDIESRTRKLDRHRKAKALAARKQEIEEEERKLMEEEEYEMGMRRSAIGQVSTAAAALSQTSPSIATPTSTITPAIATPTATTPVGAKPRDEETKKTVPAKRYYDDTGDKAPREKAFRAEDDRFGDGRRDALRGDDDRFRKEYYPSRDPRPEPRYDSRPYGKPNARPPPPNRDPSPRRYDYPGSPPGRGGFRRSPPPRAREWSPARSGSGGRGRGRLEDDNFGDAPRKYDSYRTDGNYPASPRDMRRDDAGPLSPPIRIDLGRKGDCRFFIVKSFNEDNVRKCMDDGVWATQLQNGQVLTSAFANCKHVILFFSINKSKAFQGYARMATAPSPDTPRPKWMSGIHWDTSPPFRVDWLSKVAVEFFRIGHLKNSYNENAAVLVGKDGQEIEEECGRELLHEMQLFAEAKLDLEMNNNHRRPGPGPGPGRGSGRGSGHGPDPGYGHSRGRGRSRSPDPGPGPGEKFITKHEDSPPRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW66</accession>
    <name>A0AAE0TW66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_561409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW66"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="404" mass="44131" checksum="6DE40403161BCBF8" modified="2024-05-29" version="1">MADDSAENRGPALEISMYVMVVVSLVFLALRCFCKARYRKPFAADDYILVVSWVFLAIYAGVIVSATKYGIGRHYNVLSHEDTVRAHLLLGTADFFAITSIAISKSSFAVTLLRLAIHTWHRAFIWTIIVTVNLALWTTAIFIFTSCSPIERIWDPLVPGTCWNARMLLDYNIFSGAWSAAMDFVLALFPWLLIMRLNMRRVEKIGVCVAMSLGVLSGVTAIIKTSYINQSAKWRDWTYLSIDLLIWAGAESAVVITAASIPFLRLALREVRTRSGSGKNNNNSGSHGGGGGGGHSHQLHSMASGKKNNKEETSSVVALSGAGGGGGHKNSTSTSTISNERVIREENIGRAIGPEDEDGSDKSSIFGMERSKNSGYSYYVRGGGERDLERQGWDRGGVGVSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ39</accession>
    <name>A0AAE0TZ39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ39"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="294" mass="33155" checksum="29F2E3710A234FCA" modified="2024-05-29" version="1">MATANLASGSSQAIFELLDPTKFVGAVNKAAREILEAVTGDPRLEHMSEETFQYAVDTALWKDYVKTPFPYARPDFSVLPKHKHVQKQSLGFGAQQHAGQFYQQSQQFPAPQPLQNQRDQPSFQQAQPTLRAQHNPSPSQSRSNDRQAQLAQLNQIAEQYQQRQPNPPRNNYKVLGYDVFVQQQETNKANLRNMLDTIQETVDMNELQREGIAQVGQNLRRAEEIASIRARLASRATTTASGADRQQMMWGLGELERQPGMMDTHEGQVERDGAGGYWDYLDSRLRPGNGEGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZR6</accession>
    <name>A0AAE0TZR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_472778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZR6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042118809" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9797" checksum="FCC4081AEB906FFB" modified="2024-05-29" version="1">MRFLTLLTLSHLAVDRVPFGTGAFDSLRLCQYCMRQDISPKLNTPLDPIRCSQALPNILCCTPCHRSRTRPPPITLTVHLCEGDKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZY8</accession>
    <name>A0AAE0TZY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_184053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZY8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="285" mass="31068" checksum="6F54C0882316A89A" modified="2024-05-29" version="1">MDFAKRIGLRKPKWDDPAESIGERLGDLRAGKYTCWQPVGRARVAWNAIRPNVKKYLDDFCPPSCSSLILELYMIGKTQETAAPTILICSSDKSTRKTIRKLIKDNGFLDRYPGIGLGDTEELPDQRKVKRMARTDDDTLSSPSSSASEAQGNEPMLGRQLIFTTASGKTRLATGGPIVWINEDAYQPIVGHVLVDEEPNSELQADTPLSDDASFDGDSDAEDDEGDPLGRGVPSDGSRTPDDLLSEDTDDEYLQGAGVSSISTQMSHVLVSRSVTEPESTGNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U043</accession>
    <name>A0AAE0U043_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U043"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="35632" checksum="1A35F839F4A364EC" modified="2024-05-29" version="1">MKEPPAKPLQLKSPPSSLSTPDIPTSVSHIIAICPVVAMSIGSGPAARRFFVLDEALSVADLDVSTLIGRVVTDPRRPDLSLSSACGDSDPFSLSDIVPGIHPRPTEFSQVNLELTGGSISGMSGGVGSLLDVAFSATQSQTLRLSSQCVRRYALGGLDARKTRRYFDLLMADEGYARRVRRAIRESGGKEVYFVVGVLTTEKSSWTRVETAGREVSLTAGVPVAAAAAGMVPPAVDLGTIGGGPVLAKSHGVVASWQVEEEQVFALAYDIVKKVKVFDSGARMGIGSAVVDKGALKARADYLAMSGRDGESDDGESEVEDEDGSEHAIVNGGALGELSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0D2</accession>
    <name>A0AAE0U0D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase TauD, TfdA family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_381550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="124"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="387" mass="43700" checksum="12346A9600A39DD3" modified="2024-05-29" version="1" fragment="single">DGSEKSKLELPLLWLRDVCLCPRCVDPDSGQKNFSTTDLPDAPKAQTAELAKDGSLKVVWEKEILDGDQDGPHVSVWPAEVVHGWVRNEGLAPREQRLQRHLPPSRTLWDRALYESMLEAGQCRVAYQDWMVGGPDFWEALHALARTGMIFVTGVPEGDENEVERIAGQIGILQHTFYGFTWDVKSKPHAENVAYTSKFLGLHQDLMYNEPVPRLQLLHCIQNSSDGGESLFSDGVRAAYELRETDKKLSQMLETKTTLFHYHKGPHNYSMLKSVIQSEAPLLIGKTHWSPPFQGPLLRKSLPVGTTELSMPGVADWKRAATAFQKILESPDNMVEAKLRPGECMIFDNWRVHHGRRAFATGQGSRWLKGCYISPQVYGAMERRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0V6</accession>
    <name>A0AAE0U0V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_540387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041781193" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="567" mass="61154" checksum="97F5B1D6AE99FF81" modified="2024-05-29" version="1">MPSLLRTLAAAALTVSSVVICVTTLDQVCTPGYAHAALPAPGFYPGITIDTTSISTSIVTNRTVKSDWFPASTISYCNVTFAYSHNGIPNDRVHVTYWVPSPDTFQNRYVSTGGGGLAINSASSSIPTGVIAGAVSGLTDGGFGSFTTQWDAVFLLADGTINWQSVHMFGYQAHRELAVLGKEFTRKLFRLTSTQKLYSYYQGCSEGGREGWSQLQRFADQFDGAAIGAPAFRYGQQQVNHLTSNVVEQTLGYFPPPCELEKIVNLTVAACDGLDGRLDGIIARSDLWGVGPPPGGPLLRQRQFSGGGPTPAQNGTVTAKAIAVAQTILNGLHDSQGRLVYLSYALGASFADGKTSYNATSKTWGLSISGLGGEWVRRFLQLHPENTLPTLQNVTYDTLKEWMILGQNRYTDTLQTTYPDLSPLKAAGAKVIHVHGEADDSIPVGSSVHYYNSVRSAMYPQLSYNASVVALDEFYRLYLVPGGAHCGPGRSAPGGGPWPQTTLQTVMEWVEKGVAPARLSATGGGIDELCKWPLRPLWLAGKMECVYDQASIDTWKHDFDAYNTPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U168</accession>
    <name>A0AAE0U168_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_447998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U168"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="18592" checksum="D2EB8C58E7AE1143" modified="2024-05-29" version="1">MSMYGSYGSSSSSYSSYTSSYGSYSISSPMDIAPSRFSSRAADASCAFPSWPRRSSLSESDSEDRATSYLSDEDLYLQDVFEDDAQSVSSHGSASPIQSPQMPAMTEAEILQAQREQAAYQREVMRFIMSEKEKRRQAAKRQRRSSTSSSSGKKSKSKLSAMTPIAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U196</accession>
    <name>A0AAE0U196_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NFX1-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_541000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="12">
        <location>
            <begin position="1907"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3386890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1988" mass="221672" checksum="07FB862299576B31" modified="2024-05-29" version="1">MAESNRRSGPGTGSDPSKPCFHFQQGSCKFGKNCKFSHDVGSKQDGRKPQNTRGGHTSALGRFQASKQSEGKLREWKRLLEQGSQLVRPSPAVISRFFGLGLELLDGDVGGAQEVIKLFASEAGLSFIKDVTDRHIATVQGSSSSLSLWDGLVMPLFKFITHPVVIDSAVLEQQVAMLFNFLCGIGGNRMAKVFGFVTALVRSWPSSAARASRMAAVELSLAVLSKILDCNTTNIVDDKFSALATTLSECLQESELSQPEEEFFRLQASSYLGYIRLRLNVGEEIAQPGPTRPQAAVTREKFLLRRDLPGNLSPDGPRHDNDHTDISKIKILPTYEEIISPRAEYLPTVDPSQWHVDGIRGRLDREFRLLREDTVGQLRDAIKETLETIRNPQKGSARSRNSARTYTYDFPTLVSVEIDNFGGLELAVRCAQLPAVQALSPRGRKDWWMQSKRLQAGALVCVLDATGTVLFYVVSESTMRSSDDKLARRNKETSQESGPGINETAAKPMPMTLSDDAESLFVTLQLVDPSKHGVGQSLRWYQNVGSSLRRYLVEFPGVLLASFKDTLMALQDMYRKPNMPFADIVAPSTSSQAESKTDSPRYARKAGFSFDLSCLAHPGLQLTVSTQSSPSPEEIASKTTLDPTQSAALLNTLLREMSLIQGPPGTGKSYTGEKIIKVLLANKHKAKLGPILCVCYTNHALDQLLEHLLDDGNDGVIRIGSRSKSERLQDLNLRNVVKSFSRTKAEKAELWQLDVGIRDSVREANDLLKQLSASDSWLNVRNFLANAFPVHHLELFGKVEDGWEIVNHQPEKTIDRWLFGGDRYSTTQARPVDILEAVPLSHMTHSERRSLHRHWVRSIRDPLIEQIIKQHQDFTATIGERDRLRKDVDLRCLQQANIVGVTTTGLARNLGMIRKLRCKVMLCEEAGEVLEAHILTTLLPSVEHAILIGDHLQLRPQIQNYDLQSTNPRGEQYSLDMSLFERLVEPRHTSKVRVPFSLLETQRRMHPSISELIRSTLYPSLKDADRVSKYPDVMGMKKRLFWFHHEQLEVGAASHDPLSTSHSNEFEIEMTTALVSHLVRQGVYSQDDIAVITPYLGQLQRLRRRMESMFEICLNDRDLQEVEALEGDNLGPSDPSPRSQLSRTTLLKSIRVATVDNFQGEEAKVIVICLVRSNPQNNCGFLRTSNRINVLLSRAQHGMYIIGNSNTYSSIPMWADVIAKLQANGNFGTSLELQCARHPDTPIAVSRPDHFVVFSPESGCSLPCEKRLHCGHACIGRCHSDILHDAVKCLEQCPRSKKGCDHSCPRLCGEACHDRCQQQLNNLNLTLSCGHIVSSAKCWEVQDPSSIRCIVQVTRTVPGCGHVVKVRCCEDVNAANYRCNATCSHRRPCGHVCSSKCFHCNTRQGGKIAQESHGICTVRCGREYSNCRHSCSNVCHGRMACAPCSVPCEVRCGHSKCSKLCHEPCSPCAEQSCHSRCAHTQCTMPCAAPCNWIPCSKRCEQKLSCGHQCPSICGEPCPASKYCQQCGDEQIRSVCVDFILMKEYHEIDLDEEPCIFPDCGHFLTRSSMDGQMDLASHYDLDANGIPKGIRGTSEPFSDDSTRIKVCPSCRGSLRNISRYGRIVRRGMLDEATKRFISWSNAAYLGLAEDLVLEQNKLQETVAQAATLSAGRPKAGTFTRPRLRSLHQVQQHAGYNGRYAEMIKLWHMISSFAGKVQEEEQPFQRVADLVKHANRMSRMNQEFRFDESIIQVKGHLLATTLLLKCEIAIFSDFFRLQSQGKAPVVQSEPIKIDWSIYTAECEQLIALARNSKFPREEVQAHIFAAQLRVFARRLDLQDSTAHDDVGLGDNENAPGGSDDKAAERLTEAALNHIKHARDLLKAYPSTAVLADELDRVENMVKDGTYSQVTAEEMRAVYTAMRKEFLGTGHWYRCTNGHPFTVGECGMPMEMARCPECGAAVGGQNHAPTEGVRRAEDIDNLEHDFQNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4B1</accession>
    <name>A0AAE0U4B1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_507527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4B1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041985194" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18545" checksum="282607BDD168C436" modified="2024-05-29" version="1">MKTTAAIVALTSFLFSTASAAPADQTENLIVDDVESSVRVTLDAFNSLDANNTIPEPAFSAKAAACTWDDGFGTIDCGYWSIVFGDGNIAGHTNVLTIKGSNFEQGFNSPLPYVISIHPGNACRTGVFPIGEYYDNAWINYANQHLDLPSDSRCGPVHQQKKGRRCIIAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4B7</accession>
    <name>A0AAE0U4B7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_557299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4B7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33836" checksum="B8A5827F66076189" modified="2024-05-29" version="1">MDGGKVTNSESSPYVVNEREKIQCERCSWLCGKHCYVTVNELRSAAKARCRICELRAHVLETGLLADEWYDGNFKVEIDELDFGINQNHKWMMECRSGCREGKDEVFRFEIFTLPERMLFKRILHFATGKILWEWREYTTCECHPRDGSSLQFNSMSLWKGKRPPVFSEDPDKACFEMVALSRRIQETKNGEPYLAGLWKDNIRTGLMWRVSHPCRNSIRPHKPSMWRAPSWSWASVDGVIDYTKKDTTNLHPDFKVLEACTTLAGPDPTGQVESGTLTVAGHTTWAEVRLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4C7</accession>
    <name>A0AAE0U4C7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">B0H63DRAFT_117277</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4C7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="178"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="891"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="822"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="603"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3390501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120829" checksum="8BAE60B64CAA2FA6" modified="2024-05-29" version="1">MLPRQRLPRLLARKSPTNALASRPRIQGFCSVQPFVRPGQHSALRLRSYSENGYKLSLSNFSSCAALGKQKGSGFFDGSIEPLSEEEKKANLENKAELETEVEVEEKDVSETKSSSSDRPSGTNGQGTPESDGKSSAAGGSSSGSTGDSGSGDGGKRGRKPGDRALAKPVVPEIYPQVMAIPIAQRPLFPGYYKAITIKDKNVAAAITEMIKRGQPYVGAFLFKDENADDDVIRSPDDVYDVGVFAQITSAFPSNSANGETSLTAILYPHRRIRLSTLIPPAAAADASKPTPAAEPVTPEPIPKSAEEVSQKGDVVASFEESAVVQKPDATAQKQYDPTSFLRKYPVSLVNVENLTEEPYDPKSQVIRAVTNEIVNVFKEVASMNSLFRDQISTFSMSQSTGNVMSEPAKLADFAAAVSAGEPAELQEVLSSLNVEERMHKALLVLKKEHVNAQLQSKITKDVESKITKRQREYWLMEQMKGIRRELGIESDGKDKLVEKFKEKADKLAMPEAVRKVFDEELNKLAHLEPAASEFNVTRNYLDWLTQIPWGQRSSENFGIQNAIKVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCFVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRVIQALKKCKTENPLILIDEIDKIGRGYQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANMTDTIPRPLLDRMEVIRLSGYVSDEKMAIAEKYLAPQAQDLAGLKDVDVKLSKEAIEELIKSYCRESGVRNLKKQIEKVYRKSALKIVQDLGQEVLPESEVLTDEGKAALAESETESKSDEPSETASEKETTETPRAALKVPESVHVVIGKENLKDYVGPPVFTSDRLYDVTPPGVTMGLAWTQMGGAAMYVESILQSALTSSSRPSLEITGNLKTVMKESSAIAYSFAKSVMAKEFPDNHFLDKAKIHVHVPEGAVQKDGPSAGVTMATSLLSLALDTPIDPTVAMTGELTLTGKVLRIGGLREKTVAARRAGCKMVIFPEDNLSDWLELPENIKEGIEGRPARWYSDVFDLIFPNLDRKKANKNRIRPDKKPEDKSDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4F5</accession>
    <name>A0AAE0U4F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_507645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4F5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="42287" checksum="87D03E6A17374519" modified="2024-05-29" version="1">MPPPIIHRPLQMRIGTDICQISRIKNILTSKSAPRFLRRVLTPEELEFNPKPKLARALAEALKPDSHSKMSSPDVTILSNFVAGRFAAKEAVIKAHPYRALSFADITIKAQMLVTKNPGGVVRREAAEDEAVANRSWPPVAIIRSNPALDTPDCHVPISISHDGDYATATCIAADEGTAQVVAPKTSTHIVADLLELNIQQAQLRLAWLLRRKPSVNIAANAPWRYEPHLIEIHTLADYIELAEQEVSEIRRRNGRHVDKKPNSLSEPEREYRVNRLQALQARVQGFERMKRGAQRRLAAELEITHLKVELQKCQRIFKLVPDVEARWDYERAQKVILRKSAHLPGQENQEPAAGEAARVISDASKTPNDGEAPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4J5</accession>
    <name>A0AAE0U4J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_557364</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4J5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="129"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="342"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="837"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="849"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3390385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="922" mass="102524" checksum="850634D116E6CF6E" modified="2024-05-29" version="1">MGRRSVSPARSEVEVDIAGDLFLDDEEIAARSGFGRIKQFKKTGNGDPAVPLDFNDLLNTGSDDGWEDDGDEAFIASKMRSSNRKTTNAQGKATKKGGGFQAMGLSANVMRAITKKGYQVPTPIQRKAIPLILERRDVVGMARTGSGKTAAFVIPMIERLKAHSPRVGARALILSPSRELALQTLKVVKEFAKGTDLKAVLLVGGDSLEEQFGLMTANPDIIIATPGRFLHLKVEMHLNLSSIKYAVFDEADRLFEMGFAAQLTEILHALPPSRQTLLFSATLPTSLVEFARAGLQDPSLVRLDAETKVSPDLECAFFSVKGGEKEGALLHILHDVIKMPLGVPEGVKEETEEQAFRKRKRGADRPNAKEKPTENSTIIFTATKHHVDYLTNLLRYAGFSVSYIYGSLDQTARLMQVDDFRRGRTNILVVTDVAARGIDIPVLANVINYDFPPQPKIFVHRVGRTARAGQRGWAYGIVRDTDLPYLLDLQLFLGKKLVVGQEVTKPSFAEDCVVGTLQRGQVEANVEWVKKVLDETEDLSMLRQVTVKAEKLYTKTRNSASGHSAKRAREVMTTKAWNQLHPLFGEDAAQAEEERDNLLSKISLFKPQETVFELGPKGKSTRNKAAEVIRSIRAKMPLRKTKKKDEDEEMDNDDDDLPVAEKVDKFAEFASDVDEMDVDGVPSDVEMESDDELEVTVSNTAVSKKGRTTFQDPEVFMSYTPRNNAAIEERAYGVHSGSQSTHFIEAAREAAMDLTNDDTAKQFGEGGRSKLRWDKKQSKYVARVNDDDGSRGKKMIKGESGVKIAASFQSGRFDKWRKAQKVGRTHIGETEKSNLVRNFGSQGGARYKHNAEKAPKDADKYRDDYHVRKKRVAEAKENRVGKYKDGEGSKKELKSATDIRKARAVKEQKMLKNARPSKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U509</accession>
    <name>A0AAE0U509_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_124285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U509"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50189" checksum="E8753991EAA8F74D" modified="2024-05-29" version="1">MDFLPVELIRLIFECCDAPTTRALRLVSGRLADVGYDYLLAPHFTSVEWKDDIKRLHNIATHDRLRHDIKSITFNFSKFDEYHARHASFFQHWNAEAEEPLSIALQDAWVAYYKMEETSRSLPAFHQRSTMVEESVKRLSNLKELEITYTKCPYDIEVFQELYRARNCMKRDRTLACKNMNAIVSAIRHVRLSSLSIDQLPLEIFRLADDRRHWFDCARSFASLSKLVLTLDPPSKLLPTARFRTINGLGHVLQFSPNLTHLSLGFQPFHAPTEKFSLSFHELLRDFTYEKLTDLKLEGISCAEDDLRVFLVRHAKTLERLRIGGPGLALPNELSIGGVHLHEGTFKSLITSLKGKLPRLQRFHMEGDIEGGEITTNSRELYMFHAVADDNWADLGPAQGRPPWPKTIDCLGLERYLLHGGEYPKLAAASPRSSWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U545</accession>
    <name>A0AAE0U545_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_520386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U545"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28734" checksum="EE6FDEACFAB10D4A" modified="2024-05-29" version="1">MTNALRAELDLNSEYMLRVNGSKTHVAGLLLYTTLLWLLKDAGEGVHKMYKIIQWAYVILPATYIACLLVVSFKCIPFHHQWQINPFPGSKLHVVFWCQPRKVIDQPSPNSCGPSISTLQTIFAMVMNTLTDFYLLAIPAPMRWFSGDYIGILRAASILTLGDIGPAQSSYWSIRELFVSVVLTNMPMVYPLFRICLETGLNIFRGGTKLTTVLVQQQQHQQSEGPRRFSLRPTPPTTDALIASFDMLNPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U558</accession>
    <name>A0AAE0U558_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_466621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U558"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="248" mass="27647" checksum="D092C069451785D4" modified="2024-05-29" version="1">MGPSQSRPAAARDEQAKIVDRIPVGRTGPTSIKNPRVVMVLAGSGCLGLTQYLTLDKLYSPNFDLITPRKAERPHTSFQPDPQIWLPMVEFVISSHSLSSAGSLQKAAHHKAWTAGLVRMRRDKVLPSVPLKYLSEFWRDQTKPTPARTIAQQRHPPTCTDALDVLIDREIALVTRQGLSRTARQRLLFTRAAQLKGWPVHERSGACACSADTRTLGFFLLLAFPRHGGRSSRLLCCFWCISNIRVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5H2</accession>
    <name>A0AAE0U5H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_467418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="460"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3391179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="809" mass="91562" checksum="BDD47B2FDB60E952" modified="2024-05-29" version="1">MASPVFKIPLTLLEKILLSQVARIAGLETTTPLALDPDNVVFRAWNWTRLAYRCLREDLKSENVAKTYNGDRSLAYRDFLHFLAHQGLLADSQFRSDALRAANPDFPGVFTQHSINSIEAGIHPDDREAWSIVSWMFQMGHLYWDPPSLTHRGRTYDIFKSVYTFQQRLARAGNFQDIESHVATHPKLLGQWTVGPAQPIEDAHSDSDTNSSLPPQNIGKRFALHPKNMAAESRPPGKPRVDETGNLTSEWLKYALRTRYLEEAVEGVLENVCMLPFADLREVSCERLEQSAVNYSVPFMERENFGRLRWVVWRSVSQTAMGAHLLYTEDEVYQYCLRNDWYFPDHFCNGEVLFAMRPVEDTDFFAKTKEFWSSWNDCCLSWDAQRKQLYLLETLPGLRFRSRRKFQDEQVAQTYFRNLVEDHAAGRLVDFTMQDLLGAEHYNTTYSQSLRYIPGDQITVYPNSFLGEGRNGKVYRATWTRPDGVLATSLRGQTVEVALKELKATGMSMKFARELDLTYTSLGGSSVGCVAFFGISTVTGPDAPSRSLRAPTDQARKFVLVSECANMGNIRDFLCNELPKRTFQESWILILNMLSGIANGIHTLHKHGVIHRDLHLNNILVTETVFPDQPQGLSSEISAKVADIGEGQHAADPGTFNASVEARDFHAPEILSSRTWSPASDVFAFAVAACKLLDKRQELCLERPPEHVLKQAGSVSKPVDDGSSVLPLKLSWIITSGLKKDRGERWTIRKYIDAIEDLEEDFSSEKDQGGVLRVEWVTLDWWTAYAEAYERIPVGQGDAQTWSAVSDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7L7</accession>
    <name>A0AAE0U7L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_554892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7L7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="393"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="564" mass="63705" checksum="EB57FF6F02F5524D" modified="2024-05-29" version="1">MTAAHVHPLSSTILRIRAPWYTGSSPTVDDAAASKQKQASPPVPAIIYKIRCQAETTEGLFLGEPFLSESGPHNAHLRGSKAINNLEVYLERNKNVSFTVYREYECCAAPLPQPARGMVEEPDISSFWKRESITIISNDLSRALGGVARSAPYEPKMQLTVLREYVYSRMGQEWGCVNALTSEGRIEAKYIDYIFVSSPATSHINTEWQNKSELQAFIAMDWLATQHDNVGHISAYIEVQYWVFDGRGQMFWKCRRQNYVCYTNGNKDQDMQVATDARYMVDNATYKQMHANAPGASPLKNSMDETVDAVMDEDEHDLGDKFFMCLPTSIYGFNMQKKEWVDLRLGEWIKCSGTRKRLICLLIDEDTKEFVKAVVTNQLNAEDNTDIIRGKGNGLFILLHGGPRTGKTLTAESVAEIAKKPLYRVTCGDIRAKAEEAEKYLEVVLLLGRTWGCVVLLDEADVFLEQRTINNMEGSALVSVFLRVLEYYDVPNTAQPSDQNLDGAQRKKIWKNFIDRLDKLHDKLRFTVAINLGVNIKEICDKLDILAQPNLNGREIRNAISTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0K2</accession>
    <name>A0AAE0K0K2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0K2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="265" mass="30160" checksum="581EB0A49D6DDC42" modified="2024-05-29" version="1">MKDRFLSSDEQLLESGLFADKLHKNIICSRSVWFHKALNGHFSEAKTGHISIENFEPELVEWVIRYIYTGMCDIATLRTGTKTNFVTCIDVYTVVDFFTMDPLVEIALSTLAAELDAKLGVIQLQYDAVDWLDELFDAMRLVYQDTPVTDKSMTPIRAAFVNFAHAARFYLMQNDQFTRFLDDEAPVFALDMFRAMRATGDFATYIPEPHCSYYKNKPTRSDKGYYTHLAPEKPRLVAACSSCATKRDFSAPTTDWSGKSTKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0L4</accession>
    <name>A0AAE0K0L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_535911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="256" mass="27230" checksum="C7F3D827DEE43CE9" modified="2024-05-29" version="1">MLRSESGGVFVQAVHGAVIPLAVPRVLAALSAGTSGGEGDGLVFRNPLSQIADMLMSFSDEAIETLEASVLLAAVPVSSDDPEGRYMHLWTICSLSALAPGNRGSETPFMGRESLDRSFVIARKSTRGLAIIAYLAINNVRSGTFVVPVSKDGHVDILLRTPMRSDILNSEFLPDRKLSAIVRLIDIEVFAAESGNQEGLRAALEAYLASTAEPEVEALVQIIGDHRTIIGSILIEFNDRGLSADKRSGTIVGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1B2</accession>
    <name>A0AAE0K1B2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_528586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1B2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25411" checksum="0478EFEB0E6C211D" modified="2024-05-29" version="1">MGDNVVDSSPEETPFPLTDVDKWVLSQTDEEYSYHTWDDLRIIIQKNDLSVLKRKPSDLRRYMKWTAETKAEYGNMTNYLLAHRLPKAWGSPPFSPVSHTPFEDPSDFRVLKNDWPYGFTPGIVHIVVWTRTVIPTDSEKGDMTPESRKTVDDFVKRYFVERLGLGGEDRVMWFKNWVALQSVRALEHIHVLVRDVDPAVVDEWTREREWHHQPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1P4</accession>
    <name>A0AAE0K1P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_489796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="160"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="436"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3367801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74496" checksum="DE263CB7BF98F64B" modified="2024-05-29" version="1">MSTSTRRLGRLLDNYLRKRLSRDIHPAITLVRDRGEATSTFLLPPDDNPQATSSKALVGRPQGEDDDDKFEIDLDEIYRDAKCEKQGFQLAMEAYESTTVGSKFKTDVTENPIHTWDDVLTEVQRAQDMYSDASGMWGRIQKGLRRFGSNGQALEAWASLLPSESEYTSVLCGGLKLIFGAAARLHDLRSDIGDALAEIPEQLRTTHLAMGIFKRSKELHQTSAALYTAIIAALHHIVVWYKEKAIKTLFKSIFKQESYAKHLDELLQDIRKQSERFREAVSLCSYERIMDTSLMVKTQGIQQAENHKVVVGYLDKSIRELQGFKGDFQAMAGDLQGEMKEMRAQFAEMLTDILAAFLSSDSRMDPGTQDLKDPNLPIRRAKSESKLIRDIPGAQDELLSAFDYNTSLAQDDIAASLRSVWQIPRPDQDRLVAAMQSPKLQCWITQTVSSALFLHFNAPRNQRSTSFIAAKLADSIRSSSSSAGNVIVLCFFCGSYSRPVVPGEDADFDVASMMRSLTSQLLIAYPDFSIHIVRRIREADLNSVGDLGKLFHLLLRQLPRHKTVFCILDGVTRFEENKALREESELAVRELMEIVSWTAEHENGGCCFKLLLTSPGSSRVLYRHLVDPEKDSVRLPAKIPSQGGYTRGKWEGSINRLGFFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2I2</accession>
    <name>A0AAE0K2I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_76313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="354" mass="38176" checksum="B015414EE11C223E" modified="2024-05-29" version="1">MADQPGPSTAEGAGTNDRAEEVQLKVEGKDGDQSTSDPIPRALSASPRQHDASPRQPEPADAAPSRKATDGPGHGSKTTEEPAPIRLKDAVGRSFSFPFNLVKTWAGMEEMIRSAHVHIERIGSLVSDGHYDIIDPNGDIILPWLWERVVQPGWQVSMQLWPSSLPAGYPNRGHQPLNRPGMPARAPPRTMGGARPPPPPGPPPPFTLPQRRRPGRGPPPPPMAGTGWTGLPPPEKAGVLQEASRKDLIVTCTIPTALPGERTEDPDSPELLKLVSARIYLVGPSGTGVSSLELIKQSHSTVPLSDEQKQTQNTRLWNWRHSTTKLMDFGEFEVSDPATGPRGDCFTSQPSATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2W2</accession>
    <name>A0AAE0K2W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_77988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="226"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="579"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="952" mass="103170" checksum="88993867ACAFEF4D" modified="2024-05-29" version="1">MPREALSAWVHNHNGSRQRKLELSPPRGSQNGRRGVVTTSQARDQDVCEAATACHHSHRPPALETMHEETWETRAETAEAPNLERDGRGGIRRQLSGPLCSPEKLSCHIDRLSSYSHSPSLFSDSFLDTRFLPSTASTGRRNSSYSASLASGRGLLGNTHNTRTSGISWYYIMMGLSTILTFFLLAFRLLSPALAIPSPRATSGYWLSSIERKGTVAFGDSSYKIFRNVVEFGAKGDGVTDDTEAINKAIAQGERCGEGCSSSTTTPALVYFPPGTYLVSKPIIQLYYTQLVGDAVSPPTLKAAAGFEGMAVIDADPYDSQGTNFWVNQNNFFRQIRNFVIDITAMPATNGAGIHWQVAQATSLQNIVFNMRTDGGDSNGQQGIFMDNGSGGFMSDLTFNGGKYGAFFGNQQFTTRNMTFNNCKTAIFMNWNWAWTFHGIKINNCGVGIDMSNGGATAQTVGSVLVVDSTFTNTPIGIKTAYDPKSPQTNGTLILDNVDMTGTQQAVFNNATQAVILPGAQKVDFFAQGRAYSNVSTAEGTPVQSPQTGVTKPKSLLDAAGHVFTRSKPQYENLPVSAFLSVKANGAVGDGKTDDTAAIQGIFDKATPDQIVYFDHGAYLVTKTVKVPKNIKITGEIWPLILAGGDSTFKDQKNPVPVFQVGQPGDKGNVEMSDLIFGTAGPQPGAIMMEWNVAGTSQGAAALWDVHTRIGGYAGTELQLEKCAKNPNVTNPVNPDCFGAFMMLHITPTGSAYLENTWYWVADHDLEPAANNGQIDVFNGRGVLIESQGPVWGWATASEHSVLYNYQFSNASDVYLALIQTETPYFQGNPIATDPFEVHAKFDDPDFVTSCAGKTGGTCERSWGVRAVKSKDIFIYGAGLYSFFDNYNQKCLETESCQENMVSIEDSDVHFFGLSTKASVSMLMVNGQKTALDVDNRNNFCATLAFFHSDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5G0</accession>
    <name>A0AAE0K5G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_440322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1882" mass="205783" checksum="05508730816BF90E" modified="2024-05-29" version="1">MISMQRSLSSPVAIHSSPPLSASATRSPTPSPSDNHVEVSHSRRLRSRSPPRATKDAAMSASGRRSDDLPRRSAAQLIPGAVPIRTKPIIDQASASSSGLAPNDSSDSLETVGSPLSPPDDQPGNMKFLRPLLTDVSLYTNPNLGPESDGTSLEELAHLVRLSKYQERKRANTRIRLQRSLISTALSARLMRSGEIAHRNLVDCFRGDDKKTFAALYNAIIDVRKSCDETRRYALLEPEMELMQSSGLTSTDSLDTPTGSVAGGNANPGIAAPFLNDISASARETFMNFLSQIRTNPDYLATRIASLNNVELAALTSFHQALEPIESVLPYHNSRPSARGPSGGSVFSGSGTPGGAGGPGGRYSTQERSAIERLLSFQRHDPISALIYTCFANSAGPDSAEDKRRTVTWANACARLISTQTTGCEQTVISVLNVWISMRDWAGKSNMEWYLMKILEDGAFLLDRAEDQHGTRFNISDWTSKDQIAAEEFYTRAVDELFEVIDDEDATGIPEGLIELGNEILKRLDKKVVESTRRWLVAKYLFTVWLLGVVIHPEAYGMMAEYHITEYGRQKILKAVAMHAQKLVVDMLQSKTPVSTRPKVKTHIENIYSRFKDSKFKKKPRLLPARSITSLRETTEVHPYLVLSPADLATLVNALFPERRPQSAHSGSLRSGAPSISGFSAISQPISVKTTQSNFDTMSVISTSAESFVSDTTTSREPLLDEGSPRRYSPLILDSAGPKQTTNYEDDGYRLRLAMHEMTQILGQDVVNGSCHPCAERWAVLFISADGSQLSTQMTYDPDDDVEEEANSSTSDTEGDETEDERPELDKDYHQLRDSILKLVQDYEIPQNLENDGAKKQTFSNRALSLKKYRSKNRIITTMGSRNPYRQRAQSFASSQAESPPKSGKGKESAESVESSSPLITMLNAACSQSRAQSDFVNAHLYWKTLQQLSSLTSDSLRRDGFATLLNIFSRGPRDSIRRSAAAIEQYDAWLVWLKQSQERAEGLIDSMMRRLRALRDKMWYVTDVRNSAPYEDSRNIAAALKTMGLPRRWDQFQKKRSQMQRGPASSYILRTESQILDLLAVSEDQGGPNKLRDEQAEKTARWLQQCGIENFCRGEERIHRFCCEVDNCVNKLVGDSIIDGPVLWSSELFARDRRTLEGAKTPRDRDSQSVWGDDSVSVISDPDRRPGFVSVARPPSTTGGGLGGLRALSGQNLSQMSFDSSRFSFSKASTVMSDIMDGQEYFGASSPVHQIDSNTTFWSPFQHRATSPSTTSRAHSPTTSLTNFSGSFHPPQHNHLPSHSHHSTGRPGTSASSNETVFQQRLSEDKTRFLGELRQTLTSLLLSDLGNHVFSRGSETDAWFEGLGQECIDRREAIQRRARQSATREKRKSAKTGLKHRIIEKKRSFGDLRGTSSNDVAGLDAQTQAGSETTGGSHHGGSVHGSSVHGNESSATSDTIHAQRQNQEPKKDAMPDFPFTKAYQRLLKMFCVHPNPYIKLNALSELEHLIVASLNSGSRRSRLAWARSDIGSASSATDEQHGPSAGISRSQPLEEAIDNIKERRSQTLFQGPSFGAGQSGRVSGGGGNMETRSVVSVYPANTDAIANVLQALFRDSSLRPKTLFRDLQFIASFVPPSVLDKTEKGKAFWDAGLAALGLKQEVCRTMVEVADDIVKNYTQTRNGSASAGSGTASNNRPGTAGTTTSSNPDSSSATGAAAEQLSPPVSPPSPLPLTTHSLADAARMWTITAKEGDSTAQRELAIFYLSNPELVPRTTLPLCKPREVFKQAVIDKYRGSKDSSRSNKYHPSAGTQAQAQRAGGLGISGGSGSGASGMDGAGGMGVGDVRSDPALMCLAIHWMGAAEQGGDELARTFMAQNEMGGGMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5M1</accession>
    <name>A0AAE0K5M1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_317826</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5M1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3370524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="511" mass="57278" checksum="BC9318F8F896D67F" modified="2024-05-29" version="1">MAIVGYISSPWAPVVVVVGLLAWYLLPYLVTFKHLRRIPAPFPAQFSNLWLLWVCRRGDRYDTVDKLHKKLGPVVRLQPNHVSINDDEAILAIYGHGNGFTKSSFYDAFVSIRTGLFNTRDRAEHTRKRKIVSHTFSAKSVSEFEPYIHSNLELFVKQWDNLIQRSRNPDGAAHVDCLNWFNYLAFDVIGDLAFGAPFGMLSSGADMAEIRASPDSPPTYAPAIEILNRRGEVSAALGTLPELKPFAKYLPDPFFTQGLQAVQSLAGIAIARVTSRLENPPAEKRKDLLMRLMEGRDDKGEPLGREELTAEALTQLIAGSDTTSNSSCALLFHVIRTPGVITKLQAELDAAIPASIDVPTFEMVKDLPYLQAVVNETLRHHSTSGIGLPRQIPEDSAGIHLQGYYFPPGTVLSVPTYSIHHSTEIWGPDANEFRPERWGNITPRQKNAFIPFSYGPRSCVGRNVAEMEMKLIVASWARRYDVYLRQDYMDTKEGFLRKPLGLEIGMKRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5R7</accession>
    <name>A0AAE0K5R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_308706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35747" checksum="B1BEDBDF72DCF88D" modified="2024-05-29" version="1">MALTARLTSHGPPTTDPEDFFASALGVIFPDDVTNQHGDPDHGLLYTSPHLPKPLHIRVADPKGAEDRRLFSHFLWNSSLLLAELVEAGTLKLDAAALTSTQAGSSSLGGSSGSSISNGNGTVKIAAPASDFDVTGCATIELGAGTALPSLLSAVLGARRVVITDYPSSEVMDTLRRNVSSNTEPSFVPPGRQLANDVQVEGHRWGELDTPVAKANKHAFDRVFVADCLWMPWQHENLRRSVGWFLSEGEGSRAWVVAGFHTGRQKMQGFFDADALKAEGLEVERIWERDCDGNDREWAVDRGFEDPGVRKRWLVVAVLRRVIANRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6N2</accession>
    <name>A0AAE0K6N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6N2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="582"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="850" mass="91468" checksum="718CCF55FB2D22CE" modified="2024-05-29" version="1">MTAPLSPTPSAALNFSTPPATASRYDSYSRGSPLSSSMENDESDNSSPFMAHVRDDMPSPQGPSPPKALRPASRIISGSELSPLKILQQLPSQQQQSQQQQQSISSASSDDNESPAKAMAPPPVPLMSPRKMSAPIKRFPVKVSSPPVVTEIPRAPSPERKISLQDAMRENEGLKHAIAIFEDEASDLIDTEAGGIEAEADTSTDTVLTATESQQHHGFDRQRQDEHENEGLYGDYDDGEGATGIDDTMMSTFSTFSSVPNMTMLAQMRSPTKFSTMGATLRTGRSEQQPPMSTSRTPRNGPLPDRSSVPPPPPYEAGNTTNLMDFTEQLRYGAGYPPQISPSRRSGGHLPSSKNTPHIAATPQRHGNSSLNLLDFDIPPMPTPRSLPSITPRELESLKSGFLSEISSLKASLSGKEAEVMSLKTAVGDAEKRVGECMEQLREVQGVHDSLTSERDSWEKRGREMESVLRKVKEEIVLGRREREELEFKLDEAEKRREAAEMMAQEAESKMAGMRAGKASAEAAAAAAGSDPSEKNNRASLGAGAGSNKEVEMAVERVARELHALYKSKHETKVAALKKSYENRWDKRVRELQAQVDELTRENDEMRLGRDATMTRVDPAAEEERKVDMARANTQIRELEAEVDKFEAVVKTIQADNAELRVLLEQERVEKGELVQLAEEMMNMQQTLAAAPPPPPTPAPAPAPAPQSQLQAPPTPSAAATRTPARSSFTGGLRGTPMTARQSAQPQQQENNPATGGANHFRASRGGSGLRAPGSSLKSSAASAIAGPAESRIGRFSHHERTKSAALSGIGGGGGVGGGMGLARPGSGMGMRSGIMSSIEKMGSYRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6P4</accession>
    <name>A0AAE0K6P4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_314235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="220"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3370310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="588" mass="66314" checksum="7BF4BEE00455FF24" modified="2024-05-29" version="1">MPPLTDDEWAEMALELPDMDSSVIQKYLQNREALISEEKKQRSDYSFRQGLSPIAKKACEIVSRIRAEEMQTTWTSALEEELAQQMTTTVFPGMMFSLAKEKMESTKLWKIVTRMPKGALLHAHCDAMVDFDYLLELVLNTPGMHVACHTSHLATAEARKEQVVDIVFRAAANTSSSLWKEDYVPGTFVLMTQAAHEFPEGGRAGFLQWLKSRCIINQTDAVEQHHGVAEIWRKFVKCFEAIGAIIHYEPIWRAFLQRLMNQLVADGVYWVEIRFAWPLNYCREGSEVPEPDYNHMFQVIEEEVAKFQATEAGEPFWGLRMIWTTLRGLGTRSVVENMDDCITTKMAWPHLLAGYDLVGPEDVGRPLADLLPELFWFRKQCAQEGVNIPFFFHAGETLGDGDSTDNNLFDALLLGTRRIGHAFSLFKHPRLIEAVKDKRILVESCPISNEILRLTGSIQQHPLPALLARGVPCSLCNDDPAILGQGTEGMSHDFWQALQGWENLGLAGLGSLAENSVRWAAFEDQDTEAWTRDVRSASVGAGIKSARLRQWAVQWEHFCLWIVTEYGDKYGDGVDDVVGAGGLEKNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6S5</accession>
    <name>A0AAE0K6S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="193" mass="21616" checksum="435A2237452B5890" modified="2024-05-29" version="1">MTERDTTGSVPSIVFTLVFRAPTGLVQPRTLRELLTTTALPDSLTDRLNIAQALAKSVSYVHTFGFVHKNLRPEAFICFSDPRTGTFTIGGQSVYLVGFESFRKEEGRTHRTGDDAAEGNLYRYPSRRGYGPREDYIMQHDIYSLGACLLEVGLWHSFIEYSDRDQAPILADHLGISDKTGPEATHQLKEFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDZ3</accession>
    <name>A0AAE0KDZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_503061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDZ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="259"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="533"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="826" mass="90664" checksum="06C78D4073C69372" modified="2024-05-29" version="1">MAPSEPKAGQPEEHKKKVNLTDVSGSERKHDDDTATAILKKKKKPNQLMVTDATNDDNSIIALSNNTMETLQLFRGDTVLVRGKKRKDTVLIVLADDELDDGSARLNRVVRHNLRVKHGDIITIHPCPDIKYAKRIAVLPIADTVEGITGSLFDVFLAPYFREAYRPVRQGDLFIVRGGMRQVEFKVVEVDPPEYGIVAQDTVIHCEGEPIERDEEENNLNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKSIGIKPPRGVLLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGVPDPTGRLEILQIHTKNMKLGDDVDLEQIASETHGYVGSDVAALCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMDNFRFALGVSNPSALREVAVVEVPNVRWEDIGGLETVKQELKESVQYPVDHPEKFLKFGLSPSRGVLFYGPPGTGKTMLAKAVANECSANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCIVFLDELDSIAKARGGSVGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDPALCRPGRLDSLVYVPLPDEPGRLSILKSQLRKTPVADDVDLHYIASKTHGFSGADLGFITQRAVKLAIKESIGIDIQRTKEREAAGEDVDMEDDAEDPVPELTKAHFEEAMQMARRSVTDVEIRRYEAFAQQMKNAGPGSYFKFPDGAEAGAGNGGAGNSFGDAGNDDGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE65</accession>
    <name>A0AAE0KE65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_259428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE65"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="19925" checksum="2B24A6F4AC7A2B8B" modified="2024-05-29" version="1">MLLLLVLVLLLLLLLLLLLLLVLLLLLLLLLLLLLQLLLNCALLLLYSAGLCNKFGLGSGDGNPLLLCHGLKLLGNGRHGKRRDKLTSNCWHSPCWNLHWPSCGAILLWYGELTRNVEPWSSVDDITGRKLSLLSLLGLNLGLGLSLSVGLNLSLQLGLRLGLYLSLGGWCLRKWNPSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEB6</accession>
    <name>A0AAE0KEB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_562666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="38471" checksum="265A98612959A2FC" modified="2024-05-29" version="1">MAYGQAAEWEYEEEKVAQSAAHPDDTTAHPGWSDDGELDYAQEKVADDVGNAAEQPGWYDGEQEHNLHTETAEDHVENDTAQAATQPGWSDDDDERAHEQSNSAARATVGTASTSPIIVKPPTVIPFMSLLRLNGLVDEPSRRFDWFDIQMTEDWENLRQQRATGVVVAHDARTRQWGIMLTLPGRPKALRLEPKPTRDKAIGKSGWNRVSVVVTALHDVVDFSPSGGKYDQISEISYRGTVEQFFRTIYDNGQCHYECKPVDDGEPLRGWMLRQISLFHQEGIEVPFDRAEAKEAKKIIREWAPDGRGKGRVERGDFVLRVRFWSLVGYELRRVFGCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEL5</accession>
    <name>A0AAE0KEL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_273563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEL5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="317"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="639" mass="72327" checksum="44CA19813FD74E00" modified="2024-05-29" version="1">MDPVSAAGLALGVASIGLQIYTGAIQGIQLLITAISFPEDCRYLNLRLRMEQQRLFAWSETSGLLDVNAKDKQKILETNTFILHRQTVLDLLVQVQCLFKEFKEHQERNQRLQTVPDQDQVLGKPEKDAEAANFPLPERRRAFIKKAMLSLRETSQEAIMRLRWVTFDKPAFELLLSRFSALNDNMTNILDARMQVEIHHTVQDTNRGVLQLHHKITDLSRLVMALNIKLEASSAPLESQMSASQKRANADGLHILSQLAKFKAFNKSIETNTRTPWDEATVMCLELRGPNEQKNLVLNRSMIEIDPAAEESDLPRCEAILQLPDGARRKVWVEWKEYDPQKPGDISPPKDVIFERVQMLAALLNHTPKPEAFRTPHCLGFFDRASSGGAPDEDEDSLNMRLGLVFERPQDDDLHTSLPPVSLRELLQKDRKPRVTDRIKLAHAISNCLLYLHAVNWLHKGLRSHNVVFFRTSRGHVDYTKPYLSGFGISRPARSDEMTQGPDDDVENNLYRHPHAQSINPADRERFKRSFDIYSLGVVLAEIAHWKTVDAIIGIDLNGSRIRSSIALRVRDILLADDQIEELGACMGGVYEKAAKKCLAGGEELKLFESDDETNDVVAARLSMVLHEDVVKPLGDVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEL7</accession>
    <name>A0AAE0KEL7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_437333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEL7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="58364" checksum="F83E6DA8427B974F" modified="2024-05-29" version="1">MNRPSRTDDDFEHPDWNQMPPFLAPDLTTRQDLNGIANARVQRSRFSGMPDASFGFLDDKNLADMNRPVTENRWPGSVPAPAMNGCLVTLPFIAPRTVLGGEGQARLSLRSTRPQSSSWIWGWVWWFASVFVAAAFVNMAGAFLPAAMSSFRAVMPSTQSIVGTAESTSPRRSLMKRSSDACATQGASPSDYNVPLHVGALFIIFGVSSLACAIPLFAAKFPFLRIPEPFLFAVRHFGTGILLATAFVHLLPTAFISLGNPCLSSFWTMDYPAMPGAIALFGIFFVTVIEMVFSPVRQFTPRPGEAGDSGGGYEKKKTTKPTTGGHCSHSTVVAAVTRPRRGSSATEPASHGSVAANSYEQDMLREESQSQGLTDEQLHKKAILQCMLLEVGILFHSVFIGMALSVSIGGDFVVLLIAIAFHQTFEGLALGARIASIEWPEKTLQPWLMVLAYGCTTPIGQAIGLATHTLYSPDSEFGLILVGTMNAVSSGLLVFASLIELLAEDFLSDHSWATLRGKRRAIACTLVLFGAICMSLVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF14</accession>
    <name>A0AAE0KF14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF14"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042258421" evidence="2">
        <location>
            <begin position="18"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="810" mass="89393" checksum="DCB419939D3B7CDE" modified="2024-05-29" version="1">MAEVLALLTSVVGLVQAVELTRKSLGAVCDLKNAPAEAKRVSDELQQINAVAQGVEKHVRSSQSPITSEPARILHSHVSALKSDLEVFRTLIEPHQVQDTGWARLKIRMKWATGLDKRLGQISSRLTAHVGRLQLAVSLYSSDESRTSSQQIQHQLSGLTRSQETEPVSHSSTDVAQAAVMSLNRAPRPAQSSPSRPASITHQLLGTTFVHGSPRLCADLLIEVSPTISKLFNDKGSLVTLTSQADWVRSQLFELLHDIYAGQVKESSVSTRLPEPPPAEKADRSAVSPRRQHAISRNTKFDPLAGMTVLFFLKISSLVDATSVEHAGDQQTLYLDSSKYQTPASSGNGIPDSFAQCRLFVISTLNSTTPTAGAIVQFSELSGTKHQLWRTLITFGVHPASSQVFQHIRNKDLAAIKRMLSLRLISPNDRDEDGNSLLWHCLSDHTNYDMCELLLREKADPSDCTRRGDHALAVVVMHMSLRGQQIPAGLKLVDLLLRFCHGKEAYGMLQYKRRKGVDHAPASILHCAFPRHQSGFVAQLPTLLGRFIQSGVDLEMTDKNGNSALLYSLFYHPVLVLTETATFLLEAGADVLAKNKYGEGCLHLIFRRLSACSIPNLSRAVKARIVDFVVRLIGAGCDPVEGNVVGYTPIDAAMSPVGWPLLCVALEKVGRSIDGELRLLDFAASISLSDAEMEEKCRDPMTLVAPQRGYYPSRIEDRGIVCYLCGRGPDVSFRDPPFDEFYSDVVDELGHGIHMIKHLHENKEECLHINEEDSCHNLDYHPAEMIGMRLEGRSIRRYVAASLWKRGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF24</accession>
    <name>A0AAE0KF24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_280908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF24"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="112" mass="12861" checksum="CC6F716EFE0654C1" modified="2024-05-29" version="1">MRRALCVCARVYLRPAFARSLACSHARTPKALKLKTSGCSTQKFPPRAYRKPKWKLPVYYGTTCTCCTHVCYASSTPRLRTRCQRPRRRRMWAGLVGKTNRRGRLAGNLWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KG92</accession>
    <name>A0AAE0KG92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_278834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KG92"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3375421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="307" mass="34103" checksum="976AE7CF68119993" modified="2024-05-29" version="1">MASAHPYLAYLAYFFASYTALTLSFFMLSFVVPKAAFVARVLASYLALLFTAIYGVVASILLRLAGYGQISQWATGRHFKYMMILATGITFEVEDPKHHLETMRPAVFLGNHQTELDVLMLGCMFPKYCSMTAKSSLRRMPFLGWFMSLSGTIFINRQNSESAREAMRSAVEEIRGKRQSVYMFPEGTRSYSKEPMLLPFKKGAFHLAIQAQVPIVPVVVANYSHILWLRGLVFNAGRIPVKVLDPIPTTGLTAADVDELTRTTREVMLKELITLTEQARGQKVAVPIVNSMNGVAKASGIDLKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ90</accession>
    <name>A0AAE0KJ90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_478007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="157"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="364" mass="41717" checksum="0ACE9C6BB8F74CA7" modified="2024-05-29" version="1">MASEGVVAPAVAGLADEHETKLAAEISSLEIAVDQQQPTSPPHRSHDPQFNQKRSDPFQFGSRFLQEDDDPFEFNAWDHVETDDTYKEYAEQQYEMQRQAPVSDFDKYRFNSDPAKWWNLFYKNNTANFFKDRKWLQQEFPILDQVTEENAGPVTLLEIGAGAGNTAFPILSRNKNPKLKLHACDFSKKAVEVMRAHESYNTDLMQADVWDVAGDSLPPGLEPGSVDVVLMVFIFSALSPLQWKKAVVNVHQVLKPGGEVCFRDYGRGDLAQVRFKKGRYLEENFYIRGDGTRVYFFDKDELADIWTGKLDDPAADGEAESRHSFEIESLGVDRRLLVNRAKKLKMYRCWLQGRFIKQKEDNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJB0</accession>
    <name>A0AAE0KJB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_547284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJB0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="182" mass="20875" checksum="7FCEBE5E4AF38780" modified="2024-05-29" version="1">MADGLNEYRTSRVAEVLSDFRTLQYYIAAAPVSPADMDDYYTEGWAALRQCAIDGQHILNCAADITVPRTTGGPEEQAKAELKQVHLDAYARRHEGQKIYLRQAAAQRWVEWREQILMGGRPHSGNQSQLRACDQQLRAELATITDETIFQELLASDLNMNRWTDEDPSLRAVQRWVRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJK0</accession>
    <name>A0AAE0KJK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_546897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125422" checksum="C652B82477D3E860" modified="2024-05-29" version="1">MHGSSRDRTFTTSQLVPLGSIRKQDANAPAHHKGTETRKICFATGIDGETEIPRGIELLEVDPGIRKDGERGALFVQLGVQEFSPEAACEAIVRAHRDPSFDEAGLSPADLAFHALFLYRSGHYGRRESRLWFVAQDGTRGRGHEFYIRSARGFVASSWPREFQRSIRFLHEEYLSGFLEDPASAEAWADWLASFHGVRIFPTLVSHSSTEGPSLSEDFLSLLRCYGSGKVLELLKHQWHYYAEQLNCPNRGRGELNQPDKRVVTELGSIRVPCRGGKVVPLDQTILPSSNIPPALSSELNILDIPNPDDPQWWFLSMLVVSSKLEAPGLTRQIRVLRDSGQSMEFVETIYRELQWLQHSDRDKELLRGSFATDLLIFIPGFGRTKGAWLKTDGCVWDGHQSLHRTARLRKHYPELRHPFQNILQIGDASLVTMLAEARSIAANQDVHLQTIQDTFIAFSAMIHDNPGGLDATILRELASLRIFSIKGRCDWGAEKIADVLSVHMPDGSTAKFQADAGFTCVKEAHGELCAYLTKATLSSSQAPIKLVEQFAEICGIEGQRGILLLQQILSRDDVPSLAREFQSKGSSQKSSILVPMWMESNLTNTLTAGQAVHLLSMAAKAKNRDEVHLLPLKFTAKARQIGMHRPYEELSWLHRSCKAPGLDWKKAFPSSDLAFQALFLPQHDSVLISSKNVNNVTEDVAFLGELAVSMFLKFRLVNSYDPERCWTSPLRIKAGLPPCKSLQRWSSTFTIVDRDGAFAGLLSRLGHDNNFAFSRHTYHIEVVTTEEALERNEFFLGAEQFKKAQRLSRARNPELLEALILIRVFNVHKDPRLAIFVDPWSMIADGSLTVLHGAHYSVAFAGKVPPHISSFDFCSWIPYWTQAEYPRTISTWDTPSGGFRASGNTKLDAYVHRRDNTILVARGALIDRIKGVGSVTHNSTDAVEYINSLHADVDSLPTPYPTSESADEIKRRLPVGNASRPHLDPRAGAITAHQALAGPMGDGGEFSLLRRVARAATAGEPVSNFERASAKASTKSHTATAFSVRLSVAKSCVTELGYIGLVPHDAEVGDTVIILDGAAVPFIMRKRDKKAEDTLPNILMGECYLHRIMYGEALEFDEVETELIQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKC1</accession>
    <name>A0AAE0KKC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_477547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKC1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="57"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="36749" checksum="ACB30C142CB58910" modified="2024-05-29" version="1">MSRPERIERGCRKLPTETLVPSRPFEMDRADFYAPYGPKIIKDSPPPTSRPATDGYFHPFKRLPAEIRANIWNMALGHRILKTKLFTRTEPSGVESRNLWDRVRPRPIVTPTPGLLRDVLETQSLRLSCWEAHNELRRLLPDRLPVRVTRRQTVLVPYCRERDVISFTQISHQISQCLDGTFAADIRILEKLTAGVPMDAKNLRSLRRPQVVFSEELCCLLYPEIVCLLEGHQVLQPAVDINPAFLNYQPPDPAAEEENHPPFYLRLQFLPVRRDGSVDWLCVGPDGERAVKDAGDSSDEAGYGPCRCGTSGDEEEAGESSHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0MZQ5</accession>
    <name>A0AAE0MZQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_530094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000030">
        <property type="protein sequence ID" value="KAK3365382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0MZQ5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="218" mass="24949" checksum="575EBCAC13D0E887" modified="2024-05-29" version="1" fragment="single">LGLATNVFKNVTDIRPECIYQVNDAELFFMEQYLDDIFSNHLLQFDDIIRGPFVHLAFYESGNVSLASIDARMKRMTHAMTIAQRVLNLPGDVNNTTGRHRVTGKTFRTDTCVIVRWPWLAFPTILAFATLVFFACMVTETRWGRHGETEVTRQNYKTELVPLLLHGLRLKEEQQQHGGGGGGYYEGIGTAKEKRKRAEGIYARFEDTETGWRLVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N250</accession>
    <name>A0AAE0N250_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTF2 and RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_454882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N250"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="44"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="414"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="547" mass="57866" checksum="DB5D6566C616F778" modified="2024-05-29" version="1">MATNGNINHHDQYKSSADQYAAPTTTEAPTNASSGNTHLPKDEVGWYFVEQYYTTLSKSPDKLHLFYGKRSQFVCGPEAEVSNISVGRQDIQERIKQLDFEDAKVRVTNVDSQGSGDQIVIQVIGEMSNKAAEPKKFVQTFVLASQPSGYFVLNDIFRYIDEDIEEDPEAAVQDLSSVTHDAPAPAEAEVEVKPETPVSEELPQAKEPVELDAAIVDQKLEEASSAAQETPPISTSGVLPAELSEDVQEVATPKESVLEMLPEPQQAVEEIAEEEVKKAEEPKDPAPTPAPAPPAPVPRAAAPPAAAQPEKPKEAPKPMTWASRAAAAASAAAAPRPPVALPKAVATPAVPAQPRAPAPAVAQQSAPAPTQAVESTPAAAATKEQDSEWQSVAETNRKARLQATAAGPPEKEGTMAYIKYVTDKVQEEDLKNELLKYGELAYFDINRQKNCAFVEFKSTSGYNNAVAANPHTVNGENILVEQRRPKANAYGGSNYSATRGGAAGRGRGGFEGSRSGQGGGRGGFPGQGRGRGGGLRGGRGASVAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2A4</accession>
    <name>A0AAE0N2A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_528646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2A4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="246" mass="26855" checksum="7A0C2B5D506677A6" modified="2024-05-29" version="1">MSTWDSESDDNINEIIPSTSSTVRVDTIEADTLQIAADAAAVAAIWTFGLGMAAYAVFETEAIIEKGVISSKAKELNGKLTAIDANISARINQNVNLYVIQYKSNNDLIASKAPKGLDARTCRSILMQFMAQVHEYNGTLDIAGFKKYAEAARRLYNSPEINDVYDALDKLNLSEESDADVQQFIELVKSQNFDSVVMILLRNIAVTSMAFSLNIANQTIRDCAKAAGFEVAEVESSAFGMLDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N326</accession>
    <name>A0AAE0N326_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_565109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N326"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042123807" evidence="8">
        <location>
            <begin position="25"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="152"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="614"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3368415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="919" mass="99203" checksum="DD12797C914D633A" modified="2024-05-29" version="1">MSAMFKSSIFKLLFALSLAGWAVGTQPPLDNGNSDRLSNGTSSSPMRFIIEFQKGTNHDSLRNLLAARKGFKIIKSFKSDIFSGVSVESLSDSVDTLEAIHSVAKVWRSRKVMLEKHNSTLERVFANDASAPKYNIHGMTGVDQLHAEGTFGKGAKVGVVDTGTAYDHPALGGCFGHGCKVAGGWDFIGNSSYPFGNATKMPDADPYDQLGHGTHISGIIIGKSEFFTGVAPEATLYSYKVFGTVDAVYDDVLIEAFLRAEEDGVDIITASIIGYSGWSENAWAVVGSRLVERGIVVICAAGNWGTSAGPFFHSNGASGELVLSVASVEASQRAAPAFEALFHAGRHINATKIAYYRSEGAFPRTIEHLTIIPLSGNIAAENEACDPLPEDTRNLTGIVILIRRGGCSEFQKQANLEAFGAQYILMFNDEEAIGDPFFIGDTFAAIIEARAGAAIIDAVKAGMNVTANFDLDPLTNYVGMIDPASGKPSDFSSWGGLYDLQVKPDIAAPGGRVFSTALGGKYETQSGTSQAAPYIAGVAALWIGKFGGRAVHGPGFAKELIAKIIQSGAPVPGARSDGSLYGFIAPVMQMGNGIVDATKVLRCKTSLSFAKFGLNDTAHFKPTHTVDITNNGPAAVKYDFGFIPAAGLELWVPYDPEDVSTPRIKYEWRELEPTAMVPSITFPTGEFVVQPGETKTATFTFDYPKGLSNIPAYSGKIMIGGDNNEVLSVPYFGIASNLRADIGGQFQPGTPYFWSGPQYPYATIEEKNYFSFNLSIEAGDYVQAHARFLWGVRELRWDIFDANWQESQWTYPPVVGQQGYIGSVAYYSDSGGSQGSHWQFDPATDNANDTTPFPEMFLYRTAPALIFEPQFWWLGKMADGTHIPVGNYTMRFSALMPFGDPTVSADWDKVVHSFSVIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N383</accession>
    <name>A0AAE0N383_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mannose-6-phosphate receptor binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_441836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N383"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042169402" evidence="11">
        <location>
            <begin position="23"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="41"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3368595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="40589" checksum="0EE249A26EA74530" modified="2024-05-29" version="1">MHPPNPRQILLAFAALASLAYAEDEKDKPSATATSSASVVTPCVATSTGGSFYDLRPDVAVVVTEGEKTPRGNPTEDYMARGWDYGSNFTLNICGAVVKTPQEIVGIEKTLWKNVSAYYESKGKVYSLGFQSGVLVPRGRKLVLTYEGGSPCGSDDKTKKDKREIVHDGAAFKNHNYDDEDDTEELALLTGKGEEAEKKDADKDKDKEKEKDGVRRKSAIISFLCGQDLDSPTAASFVATDKDECAYFFEVRSPHACAAAEPHTPGSVGPGSVFAIIFFITVLVYVFGGIFYQRTVAHARGWRQLPNYSLWAGIWNFLRDIFIITTSSCAQFLPSRRGYSSISPTNGRSRNREDENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3C7</accession>
    <name>A0AAE0N3C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3C7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="119" mass="12568" checksum="42A4599B16C16B56" modified="2024-05-29" version="1">MTPPPVSGFNIKASNTIMFITASCMLACPAASFIGRSHSKSTLLLHSSFVAMRNISPIIASQQISPALLPTRALFDGDEGLEPRALCSLSNGVLRIFACTVLAVVLLMCASATTKISRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N415</accession>
    <name>A0AAE0N415_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_515207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N415"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3368654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="598" mass="65846" checksum="765C043D77C29901" modified="2024-05-29" version="1">MAPLTPYTYFQCPCSDPSTQARPGDATGADEVEDDERTFDPRAPRSNYSLYPLEYLLFCEDCQQIRCPRCVAEEIVTFYCPCCLFEVPSSNIKSEGNRCTRSCFQCPICVGPLSVASHESQSDPNLLPAPDNAAPPPHAGSFILTCSYCHWSSTEVDIKFDKANGIHAQLAKIRNGGATRLTAKERKERRKDLLHAGSASAAAAVAPRPEETPVDGQDLDLETQFSNLKFFYQSQLIDATSGNSGLTSLSDLGFSSPTSLSRIMNIYTGGSLHDKKSKSRVGTMREALDSDEGLKLADLDESGAIEKLQEEGYDGTISTKQRLSQPPHLGELHLHGNSRFTSQLRPIPYLLRTKRAKRCPLCRHIISKPEAKVATTRFRIRLVAGNYVPSISIRPLNMPSASSPALSPPQDTLQPLKPVQFLLTFKNPIFEPVKITLATPARTPGRFASKVTVLCPQFEIDANTDVWDEALMKDGDKDNRKRRKASADENGQYQAEAGKIWERGRNWVSIVVEVVPASLRLDTLAITSPAAAEGEAIDTGPIREDEDVLEIPMFVRVEWEADTAGDDIGSALNKEKDGKEKRELAYWCVLGLGRVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4C7</accession>
    <name>A0AAE0N4C7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha and gamma adaptin binding protein p34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_314960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4C7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="380" mass="40995" checksum="E54BBAAC232540E6" modified="2024-05-29" version="1">MKMAATKAKMEIPNPRRILAVSLADSTHHLSQVIQDLTGSAPQPATDLVESTAFLAGTTHFLSLNTQYYTASVPVWLDVVVDPADWAESFLSAEAREVLAVLGGLVVVFGLPPPSTSSSSSSSTSASRKEVDIKEAREKTKELIGHVGKVVREGLGGWEWDGVTLGVGVGDLGGENDEHEEMMDEWEDYCAEAGLEFVHFSTGGGTSSAAGKDKTEKKEKNEFGETVGIQRVLEALQANDWSGGAEDDDEEVTTTKKLEGGDEFDPDSLDFGIDPEDFEGLKRAIIWGEGEAEDDGEERGESSAKKKPNDKAVPAVPAASGEQDGGGGREEEEQLDDEDVQKLQRMMQKLQAVRDLSAGLPEEQRKRIAKKAVTEVMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4L0</accession>
    <name>A0AAE0N4L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_304691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="171" mass="18838" checksum="A4AEB61C87831D04" modified="2024-05-29" version="1">MVLGHVSLPTGPSNFKEMRDFYVAVLKPIGYGVYMEKDGNFCGMGPKRGSPDFWLHCGGEDFTRVDATASPDENLKSRGRSHVAFNAASRRQVDEWYRAAVKAGGIPNGEPGERDYVKGYYAAYVLDPLGNNIEMVHWSPWWLTAINAAPTYGSVVVGAVLGYFAQQYFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N538</accession>
    <name>A0AAE0N538_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_317839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N538"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="138" mass="15450" checksum="64FDB4AE00796CB9" modified="2024-05-29" version="1">MKLATAIFSALAAAAPQLEQRCRIGYGIQPCWVRWDHMECEAYIPAGVKYVFDDANKQITITGLCESCSRALASDRVRKFSDSWAFSFGHVEDRGNGTFVVTDAVDWSTQFLKGLKPHPQAWADSCVWVEGDPQPEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N551</accession>
    <name>A0AAE0N551_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N551"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982180" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18158" checksum="8ABD1376CB943332" modified="2024-05-29" version="1">MLSNTLLALCALASASMAAATPVAPEAIAACGETAAKVCFGTNGGTAQNVDPEDVAFAAASLRYIGQSNTGDAAFWNMPKSIDCEEWMLPVSNGGTVLALAKHINQRVNSSILFEDLANAIDGGEDASAAAIKGSLLGCGAAGGMVGVKANTANPLYNTAAYKASGAKPDGILIKIVRAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6Z5</accession>
    <name>A0AAE0N6Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_439622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6Z5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="439" mass="48829" checksum="51EC2ABEA24B1646" modified="2024-05-29" version="1">MPSATGANWEKYNKKFADDEVEEKKITPLTEEDIQVLKTYGAAPYGAALKKLEQQIKEKQQSVDEKIGVKESDTGLAPPHLWDVAADRQRMSEEQPLQVARCTKIIPDEKDESKSKYVINVKQIAKFVVQLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDASVTMMTVEEKPDVTYGDVGGCKEQVEKLREVVEMPLLSPERFGALGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDLEGRANILRIHAKSMSVERDIRWELLSRLCPNATGAELRSVCTEAGMFAIRARRKVATEKDFLSAVEKVIKGNLKFNSTAAYAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8R9</accession>
    <name>A0AAE0N8R9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_263956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8R9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042274155" evidence="3">
        <location>
            <begin position="23"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="674" mass="71101" checksum="B4EDDCB85526AD76" modified="2024-05-29" version="1">MAPFKPMAAALAVAALVSRVQATTVELPPCLDPFQPFVYSGCFQDTGSPHALTFRSNLDSQSMTIETCVAECKGNGYRYAGLEYYGVCFCGQTVSGTQLSEDKCNYPCTGNNTQTCGGSDIISVYQDPTYSPISEVTLEDYAPLGCWTDNSNLGKALTYRQDQVASGTLTTEGCLQACKDGGFPFAGTEYGGECYCGVVIGNDTYSAPSTDCSMPCNGNSAQTCGGPARLNLYVADELQSLQPCGYVPPVVSSSAPPVESSTPPPVESSTAPPVESSTPPPIKSSTTTTPLVVSSSTTPPASSSPTTPPASSSTPSSTSSTSSTPSSTSKSSSSSTSCTTTPKTSSTSSKPTSTSSKPSSTSCTTTPKTSSTASTKSSSTTKPPTTTPPTTTSKTTSSVCYSTTTAAPTCEYKCGKWCSSPLPDWDDVPGCKDGHSNCKLQVAACFKYAGFPDNLECFDYGSWCAGVSNYCGGVPKGGKCSKKEYIVKKQPKGYKPPTTTVITVPCKATSTAKTTTTSSSTTKVQPSPTNICKQPTNKQYGYGPDSPVADIDLPIVTCNDLSKDFSKYPFKLYNENQSSQCKSYPRNSCTNACADACKEQYDDCNDVYVQSCKGKRSTPNYFHWARDTVVKRTSGWTDSYNTAVNKCKQQYNDCLYVNRDSTGAGKCSSYGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9I9</accession>
    <name>A0AAE0N9I9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_273265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="344" mass="37358" checksum="E88C7C7C4E90FC48" modified="2024-05-29" version="1">MPPELIPDDEDYASEEDSDFAVDDVPGEDSSVSDGEGPAESEKEATPAKRKRQAGDVEVEAEDAGFGNSGDEAIIQKGKKRRKKSKAKDGPTIDDEGGEGGLIKTRSMRAIEKIVRKAAASSGPVTVDVDALWAQMTSEPTVGPLSAAGQNETRDSATSQPSNGDQPGIISPQKPAAVGPYKVQSETIRIKRTYNFAGKVHTEEKLVARDSAEARLYLESLGENDDPNADTESSSPPKRMPKKAFRSAFEPITDHTLQRSDLNLGMSVRLRARELANEANAKKLNTVEKSRMDWAGYVDKEGIKDELQLAGKAKDSFIARQNFLARSEAKRDEDARRVRLAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9S0</accession>
    <name>A0AAE0N9S0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L40e family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_453249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9S0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="5">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3375480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="113" mass="13172" checksum="5C6258375C43514C" modified="2024-05-29" version="1">MEGVLQWRPDPDIHIHTETWCGFCATSSLQVVFSPSSYIQVDRTTCYFKMIEPSLKANSPPTRNTERFSLASRFNCDKQICRKCYARLPPRATNCRKRKCGHTNQLRPKKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9U9</accession>
    <name>A0AAE0N9U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_513338</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9U9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="368"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3375403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="594" mass="64254" checksum="D50CD22332ABECCB" modified="2024-05-29" version="1">MLRTCRPTRILARIPSPWSPGRPAAQCSALAAKSFSTSRRATAPPPPAAAAAAAEATKDPTERDKITTLSNGIRVASEDLPDAFSGVGVYIDAGSRYENDSLRGVSHIMDRLAFKSTSTRTADEMLETVETLGGNIQCASSRESMMYQAATFNSAIPKTMALLADTIRDPKLTDEEIQQQLETAEYEVKEIWSKPELILPELVHMAAFKDNTLGNPLLCPKERLGLINRDTIQAYRDAFYRPERMVVAFAGVPHAEAVRLTEQYFGDMKGAAAPALSRSGSEISVDSLLSESSDASTSSDSSSSSSSTSGSALSKLSGLFKRRSTPSGNGASAPSPIIQISPEDLSRSSHYTGGFLTLPDQPPPLNPNLPTFTHIQLAFEGLPIASDDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCMAFNHSYTDSGLFGIAASCYPGRTLPMLQVMCRELQSLTHESGFSALGEIEVARAKNQLRSSLLMNLESRMVELEDLGRQVQVHGHKIPVREMTGRINDLTVKDLRRVASMVVGGMVENRGNGSGAPTVVLQEATDPTKQKQTRLTWTQIQDTIYQWKLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC65</accession>
    <name>A0AAE0NC65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_547576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC65"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="466"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="563"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3377953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="611" mass="68897" checksum="160019C19DDFFCF2" modified="2024-05-29" version="1">MAPIRDPNTLSNYDAWRTKHTTANFNVDFAAQVLRGSVVIELESLTDKASKEIVLDSSYLDVSSIKLNSASSQWEIKDRTEFSGSPVHIAVADGAAKGEIVKLEIDLATTDKCTALQWLTPAQTSNKKAPFMFSQCQAIHARSLFPCQDTPDVKSTYDFNISSPYVVVASGVPVSDNAEETGDNKLYKFQQKVPIPSYLFALASGDIVAAKIGKRSSVATGPNELKASQWELEEDMDKFMDAAEKIVFPYKWGEYNVLVLPPSFPYGGMENPIFTFATPTIISGDRQNVDVIAHELSHSWSGNLVTSCSWEHFWLNEGWTMYLERRILASIHGGNAHFDFSAIRGWSALEEAIEGYGKDHEFTKLVINHKGIDPDDAFSTIPYEKGFHFVYYLDRLVGRENFDKFIPFYFTKWATKSLDSFEFRDTFLEFFSAPEYATLKDKISSIDWEGRFYTPGLPPKPEFDTSLVDVAYELAAKWKQKDFSPSPSDTSSWSGNQVLVFLNAVQDFDEPLTVEQSQTLGKTYGLSDSKNVELKSLYYQVALRAKDSTAYQGVADLLGQVGRMKFVRPLFKSLNKVDRELALKTFEKYRDFYHPICRQMVEKDLAESKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ND18</accession>
    <name>A0AAE0ND18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_479171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ND18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="107" mass="11415" checksum="37F62BF33CEF6048" modified="2024-05-29" version="1">MEATSTPRITCGYLDSYVGKNVIVVGKVVQLRGDEAIIDADGNITAHLHREAHLAAGSGVQIIGKVNPDLSIKVLSSIDLGQGIDYNIANTVVEVAHQNKALFAYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG05</accession>
    <name>A0AAE0NG05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_193055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG05"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3380794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="354" mass="37325" checksum="605DE24BB5EA8BA6" modified="2024-05-29" version="1">MTTMKALIYSSTGQVSLVDYPKPTLRSPTDAIIRVTQTTICGSDLHILKGDVASCTPSRILGHEGVGVVDSVGSSVRSFRAGDRVLISCITQCATCTFCRRGMPSHCTSGGWMLGNQIDGTQAEFVRIPHAESSLFAIPESAATREGEAALVMLSDIFPTALECGVLNGKVSPGSTVAVVGAGPVGLAAVVTAQLYTPAVIIVVDVDDNRLSVAKSLGAQYTVNSKTHPDVAERVKALTEGGLGCNAVIEAVGIPATFELGQRILAPGGVLANVGVHGTKVDLFLEDLWSKNISITTKLVDTVSTPMLLRLVASGRLEPAKMITHRFKFSQMEEAYKTFGEAAKHNALKVLIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGS5</accession>
    <name>A0AAE0NGS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_396245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGS5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="400" mass="42766" checksum="8CFD684C41973177" modified="2024-05-29" version="1">MTGATGGGGGGGGGPPLGAIPGANDNLGEKIDIIVWTLVALSGVILGLRIWCKCAKQRGLWWDDNILIVAWLFLIASAVIGSVNRSLGFGRHVFAVNPANFPAIGLNGNLAATFSIFAAVWSKTSFALTMLRLVQGPVTKSFVWFVIITMNLAMYITIAFTWTRCTPPDKLQQCIDSNVYVSYSIFSGSYSAAMDFILAFLPWPLVWGLQMRKQEKLGVALAMSLGVFAGITAIMKCIAIPTLAHGDFTYDGAELVIWGDAEVATTIMATSIPVLRVLFIDAKTSAERHYGGSRSKRMGGSSSGLQSRYNTIISANKDRDGSHRLQVKGSDKTIRAGAADDGSDKSILDGGNKSHAGKIVQVNEVRVEFSERGVHEESEGWYEMTDVEVENAASSKAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH09</accession>
    <name>A0AAE0NH09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_475346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="415"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="684"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118688" checksum="E0D618B0238C1FA8" modified="2024-05-29" version="1">MAGSTTVLDHAGSMPPTNGQNFVPFHGGPAARGGGGGGGEPGEPGGTGKRRALAHIVDVVSVTVDLDPHAPIEKVLQTAETYFKQAESANTFGRPDLALKDFIRTNIIVTDVIKKNKTWPALQSDHKAQWERYQRLVRKVNAKHPEYEKIKAAIKADNVKSGVQPTTIRLATASDSIEPPRPRPDIFLADSSANDGGIKTNGAVANGDVKNGETRENSATHRQPPPPPPHRSKPVVHPKPQALHGNALQTAGAGGQSSKMSNDLLQRFANLRSPSASPGQDPRIRTQPIPSSQMQVTQDSAVSQRPSALLAGASTDMPRLPDAIYNPARGTVSSEAAELPSSAPRAMFTRTNSAASVPGPPKITKATQSDEYFVTAQTFDSTASRRKRTKPNIPEGALITVEDLNMFMRDDDVLILLIDIRSREEFDEGHIFTQNIVCVEGEVLTRENISAEQIEDSMVIASAAEQRLFYTRHDFDLVVFYDQETERIFTVSDNPQKKAVRGLYNALTLYDFKEGPKPKLKLLRGGLNAWTDVFGQQSLKQGSSAAMNSQLHLPPRKPVAKIPFLNRRPAWVRPIQDPEEARRWEQSVHDIINMSPIRTTEDFLRRFPAISPTQESMVSPATGHARQSHEEILFSSLPGPPAVPPPTVPRRSYSGLAEDKNAADMLSSRKASLISGAGHRRYRTGLENPGVHCFANSSLQAIFATPGFSRDLVKECWNDRYQIPGKENERFKNPQLLIKFIGALCRWLDEGTKEYMSAGTLMEYIKSIHGRTPDGKQKPDRDVFGGSSQQDASEFMFFIMDVIDDETNTRRNRKRDFRKEYKRGDGTIVQNALHFWQTHSQSSDSIIDRYFRGLDVFITRCRSPSCQEEIRNFQVSDWYIARFDAEVQDTDLETLLSNGQEWENMPDLRCEKCNSLGRSRVHKFARLPDRLVICISRFKGAPGSKAASKNNAKVRFPIRNLDLTPYMADPDPNMLQTQDHHFAGRMMYDCYAVTIHKGREMSSGHYYSFVQDDQSKDPTDWFCVNDTHVARVKIDSGLSADMTEKMYKDDNASAYMVFYKRQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHP8</accession>
    <name>A0AAE0NHP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_211116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="721" mass="81208" checksum="27B50D1D4663C8EF" modified="2024-05-29" version="1">MSPPQTRSRSAELAEFDTISVKPRTTGKRKSTKATKTLPQKKPKVQRPKDSASKPNAADVYDDFGEDADSVDLQALDVINNGAARSRSGIEIPLQQRRPLRNSKQKERKVEPAPTRDLPNATHHSSPSNKSDDTIRVRLLETIPEAVGAGSEGQRRPELEDEAENEQPPSHRGEDGENREVASEEGREGTGIDIWDLTRKPQQDDADDASDSDLFVDQHKDWSLSPEPQSSATKSEATINGLPLQRRPRRIPVPQPGVEQSSPLAYRDERAWPATSPTPIRWLSDNQSSPNMRSRDIGRRDDASLIIEDDEDAGPNISLSIRAPSTSEVQVTVEVSSSCIIRIRSLMGKEGWTNMGDKWSATLLNSTEPGKDTPATTRLGEKCFKQMVFLKKTVGDGYPGQFIVEQNNWLRTADKKLNKSMEEIEKVIDVICGDRLAVIGDSARDGQTNANLEVRQALTSDLAKSIIPMLALVLWSLFALGGKELGPNGHPQLLTEGVFTSSILKYMRKVTAWISRLDRVLMLELQKRPLEQVIEGREKTRQTIRRNRKMLRDLLDEWKDTLAEACREHYELVAGENNRHEAMERDRALKEAKDRAEEDELARADQQWAAMALSTQQIKGQLPLNKVKWEKSSSGLLPPSSRVSKGKGIAVDRRLWAPDDEKYLLRQLRLRNRELDLDDLEEIHDMLDYPVEDIRRKIEALKQSARSLSWERGLLVENWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHU8</accession>
    <name>A0AAE0NHU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_511541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="551" mass="62642" checksum="DE2C285B5BA052B5" modified="2024-05-29" version="1">MGSSRDFKTSLGPGKGSEESIGQSLTNGGLIQSDSRPVKGVQLVQVGRENLGHTLPPRDDYEGKHRWDPEATWTPEEEKKVVRKTDIWLLSWLCIMFFGLQLDRGNLTNAFADDFLKDMNMTSDDYNNGNTIQLVCFMAAEFPVQLLTKRYGFRYILPAMMCAWGMVSWAQAFMVNRAGFFLTRALIGACEGGFIPGTILYATYFYTSLELSLRLAIFWSTLNVARVISALLAAGILKMRGVGGHTGWFWLFILEGVLTVILGLISFLYLPASPTNTTGPLFRKPWYTEREEVIMTNRLLRDDPGKGLTSIVERITWKNVKETWMDPSLWGLFFIGLVAYIPASPVQGYLTLTLRRIGFSTFDCNMLTIPSAVLQVITMLALAYSSDYFNERTLHCLFGELWIMPLLVALLTLPDGGREWPRFTLITLTSGYPYFHPIVSAWISENTFDVRKRAVAAATYNVIVQMGSLISSQIYRAYDAPYYKQGNKVLVSICALSAVVFILQRQYLVHLNKKKEERWEQLSEPERLAYQNDIHEREKDGNKRLDFRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI11</accession>
    <name>A0AAE0NI11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_451144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI11"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40408" checksum="789D4FE47E34B4D9" modified="2024-05-29" version="1">MSTSGLPSCGANRQVLQRARVYFRDVIAVLANRQRLGWPECASAEGREHVDGLVACAADNFRFLDERAVFLAAMCGKSMAVEMNVISTAEARKSLQQSRRMELLTTLAFVVRVLVKGPSHSASDFVTQKGSQVLHVDSAQLTYAPIHGPSQHRYQIAATSDPLSIATAVVGLVATAGKICLALSTFVSSAIDAPQSARDALAAVEDVRLALDLAKGLVDTVTNLPSNRRMLARLNHIAITFSNCVFTLSELESLICYKDSIMHRMRWAWCEKKILRLLPRLDSQKASLSLMVTVLMCQSEMEALAGRDRLNAAVEQILQRDEEFAARVRNLDEMHVAENQSTVRDDGAGIRGPFGLRFVDQRYAVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI90</accession>
    <name>A0AAE0NI90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_416907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3381993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="36051" checksum="E7731989540D916F" modified="2024-05-29" version="1">MGWFWTDATAAPSPSAPGPTAPNHAQATGDASPPPGCPMHKPSAEALSSSSCQRPSAPTTTTPPSSGCPVPHGAREAASAEQQPSILSKLNPLNYMFHSISQEPAPNQTYVLPTTRDPSSIPKGDGSGNWEYPSPQQMYNAMLRKGYTDTDIEAVPGMVDVHNLVNEGAWQEIVEWERRFSKGLWRGWEISKRGEENAPLALRRLEAQEGPEQEGPSLIRFQGRPKEMTPRAAVLQLMGRIYPSKFACDPPFDRHDWYVSRTVNGQTKEIRYVIDYYSYSPHPDAEPVFSLDVRPAITPTAAAERLVRWGGDVWWRAKGKDVGETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPI9</accession>
    <name>A0AAE0NPI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_543632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPI9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="33"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="845" mass="95892" checksum="F20882F48B1C88E8" modified="2024-05-29" version="1">MDSSDASASGLKGGMGTWQRYKLGPIHGLKVSRKAKKRVAKDIPEAEPEPQLVALKALESMAQTIAPFNILRDVVGLHKRSSRFFQAAASRSADKDLRKSNTTHLHMIKILDSILGKFEVLRSKEDTTSQDAKPGSGVSVDDLKNMFQHLRGEIEVDNQSETSTSGGKKSTTPKAKKKPVTKPKNRTGTNGIDSWINDFSFLSTASMDALDDADPFDPYMLICCLFEDFNLIKDYVVERWCDYYYEDRPTRVDTLVVLTNAAFEMFHKPEQDLNTMMLMDPQNPSGIPIWHKHEIKMGEEADRLGMTANSIPGPTLKFSPKGATSMAPHADGPKPDDTYGAATRYEKFKLQVEIVQDILQDLNVIRALKRDGPEGFLLPAESEFMLDFEDALRRVYDSDTERSIASIFSLQLWLDIRTTFETKVEDAFVQMQAKANHVRRMLVHNLDLATGPRKHSQRGMERKIREIDRFMIKDITYHENNFIGIIWGTTMKLKISSRTTSSNESRFGRGCLSTHGRWPLMETWLATAYTNEGVFRRGLQILDPKEIMHNFAAFAPLLGTYTHITPDQGDECSKEIMEDAKSSDGSKKLTNRPSKTKVDHQILEACKRKEFAGRIGIRESLYSRYAYNRRDCYYFLQYLEEPTVHRLKIALSKTFTTNRSLLPTPTSGVLRNKKGKIPESWSREDDEPDLFYLAAGLGALDEAAERTLKQGAMLAQLPPVHILKLLDENLTTQLGDVLELDYLTLRREATELVYRVWVDTEDRRTPEEGGEFILEMDIEKFDPDTDEPDMLAKLLSFLAKAMDEDEEGEVYCEGEWVHMKKVVYDSSSDGKAEAECPGMFRRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPN0</accession>
    <name>A0AAE0NPN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_559865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="654" mass="73675" checksum="4EEA2B9A46ABC327" modified="2024-05-29" version="1">MRLLKTDTLELVEFVGRVPPYVILSHTWGSDEVSFLDLKTVSKAGLKKKAGYAKIVGCCARAIEDGYEYAWVDTCCIDKSSSAELSEAINSMYRWYHEAEICYAYMSDVSLEVQPPSAPASVSSGYGGKKEANEHGSPRPPPFRTIPSLLRDYETLPRTFQNSRWFARGWTLQELIAPPLVEFYAHDWREIGTKFSLRKDINRITGIGINVLEGADPSTCHVAERMSWAANRQTTRIEDAAYCLLGIFKVHMPLIYGEGQRAFFRLQEEIMKTTEDYTMLAWGLSKCLSSNLHTWNMKGMMQHINPVDQRRPFADSPDDFQLQSRATWTYSRLIPDLSQAKAAQEGPEDDTPPLMTSRGLRLSLLLRHPKTQSSDIQAYINCRTSRPGASQDATLSPVCLILRRQEGSNIYTGSDNPNNAFVLLDNDRELAHFTRKTVYLSTATKDTVLSQIHNHRMNSLDKTLYMLDRPKPPRMSSTSSTDSSIPPPKFSWKITSCFSHAVGAGRGHAHYEVPRKFTPATLFQPFDLPPSTARIFAFEPSHVASEAFAIVVGQGWCDIVPIHDPEFKAAWGGENGVLLVRDGYWNEGLALKFICYVAQKPCQFSYNSEEKGEAVDRVERRFGNFSVLVSLKKARRGDINCESAIKILWVVTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQD8</accession>
    <name>A0AAE0NQD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_186211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="339" mass="36743" checksum="3D6D5276A42A31B0" modified="2024-05-29" version="1">MASHPEFGEKTPASEVAQAFGDQIRGKTILVTGISPKSIGQTTALAFASQSPELLILASRTKSRIDEVAAEIHSKYPNTRIETVLLDLGSQASVRAAAAEVARLTPKLDILVNNAGVVVTTRQKTPEGIEKQFGTNHIGPFLFTNLLLPLLRKAAETNPPGVTRVVTVSSGGHRLSPLRFSDYNFEQGKTVPPEEDHFKPLPGAFAKTTEDGYNGIVTYAHAKTANILFTAYLQKHLPKLGIAPYVLHPGTIETGLSRNQDEEVSAQFYKVAMYWKSLDEGSSTTLVAALDPALNEIKGLYIADCQIADPYPHAKDPVAADKLWKLSEELVGETFPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR39</accession>
    <name>A0AAE0NR39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_510728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR39"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="131"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3386105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="25586" checksum="3A9071B8FE70398D" modified="2024-05-29" version="1">MSSTLLRTTPALRGAFRAAGAGSIALKPAAMASTSFVRGKATLPDLSYDYGALEPHISGKIMELHHKKHHQTYVTGLNSALETIAEAESKGDFTKAASVAPLLNFHGGGHLNHSLFWENLAPASREGGGEPSGGLSKSINEDFGSFDAFRKQMNTSLAGIQGSGWAWLVKDKSSGTLQLVTRANQDPVTGSYVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAARFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR56</accession>
    <name>A0AAE0NR56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR56"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="474" mass="51897" checksum="DB71A758D9A02E32" modified="2024-05-29" version="1">MAQKIGSKSKFAPKPAQANRNQTPNPTSEPKAAEPGNVPPPTKVKVNQPIQPKVPVPKGKRSSPKGTKASNSAEETKETSSPTKPATEAAAASTPATMGSPSGSNASTGIDQLVAGVSKLQLALTGLKKKNRGHISAAPEDAAKNEQLGRLVLLVQCMQSAGLCSPDIQFCLVRYIQALSTTEFWVLKLHLTQISTIKSSPVTNEWDTVSSALNTISKLGHNLPLKYIKQAAANVISKLDKNPETFDGPNGWFLWLASGIAKRATFVKDEANESTVDPTPAEQAAAAAAAKKAPAPTAPANRGGRVTEDLFWLPELENAMFLAMMVRFRVKNLLWDGTNTRQPIPFSFSPMLVAIEREAWCSLFRFFSDNAHFNHRCKCADKTLVLKTMAAYRGTVSQDPKDAAQVAHMEGFLTQTTQLGIDDPKSLYGEHYTANPRRVSKEVFYNLHWNNDEFFEHFQHLMEILEAKKNRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRL3</accession>
    <name>A0AAE0NRL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_520516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRL3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="264" mass="27965" checksum="2EA1D03F41F33CC3" modified="2024-05-29" version="1">MSSASGGNNNCLYGMLGVDGSAPYPVRFEPCNPLREDVLWRFVLHGSSGYNIFNKAWMGTKQRLDTNCHKAGGAQCIMWMGASNDTKLTPVTRAVEDPVRKHWRVYRRCTSFISPHGNGSGRNLLPVATPQKDQATASTNTTAADTRPTDPTTSTKPTGISDISTTAASSSSTSTTAPTASTSNSDDKKEMSKGEIAGTIVGPIGALAAVIGLFLKASASVIRVLTCGRKGGQPDQQGLPHGNDQDDSHICTHILTLPKYQVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRQ3</accession>
    <name>A0AAE0NRQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_136895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRQ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37761" checksum="A4EB4EC42F36CE6E" modified="2024-05-29" version="1">MSAQLGKKASQQASPLHNISRQLFQRVPLIPAGISLAGKTALVTGTNIGLGLECARHFLQLGPPKLLIMAVRSPEKGEKAASGLRAEFPAANIQVWQLDLASFRSIQAFSSRCTSEIDGRLHAAVLNAGLAKMKFERAADEGHGTPREITTQVNYLSTALLALLLLPKLRPSITSPEPGRLSIVTSDAALGCKLEDPGATTKILDSIDMPRGYDGYHQYCRSKLLVTMFAARLAELTDPTEVIINCSNPGATKGTGFLDGVDSWLVNTVISMLYSILGRTAADASRIYVHSALVLGRESHGSFTDWRINAWPVVMYSEVGRQLAERVWNETIEELAFAGAQEVIKGLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT03</accession>
    <name>A0AAE0NT03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphoryl diester phosphodiesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_393036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="801"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="883"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128518" checksum="340032A8B2B9AE3B" modified="2024-05-29" version="1">MAHAACSLPRNQVPEWAAFYINYKGLKKLVKALAAAAQNGEPVDLAEFFFALDRNLEDVDSFYNKRFAEACRRLKVLQDRYGKTPDVVANLDDDEIEELMGALLELRSQLRNLQWFGDINRRGFVKITKKLDKKVPSATSQHRYVSTKVDPRPFAKDVAITQLMSEINKWLSVLGDAQNLDDAKSELSTRSLGRTSAKALLSVPTPLLDRLDQAIRRDDVASLDTGLSLETSSQAMLLNLLQRSISSRSRRCIAFLLRNITSLDEPDDINGRNCIHRIVTHIGRTKTASSNKTEPEAGSFPFPGAVQYAQPYLTPATSPLPTPRATNLRETTSLLSKDDEAVQMLVYLLENLQPVQRTALSTRDVFGRIPLHYAAQFGFVVVSQILMSKMQEWGQFNVENGIDAPEWQDKEGNAPLHLSVLGGHSLTTKALLVAENWQGVSDHKAEMRRSISQSSAVLAIATKSNFRLIVEMLVQAGVNINWQDKTGETALHIAARFGHDQCARVLLKGTSQQKADLELAEKSFAWTPLHIAAVDGHLSVAQLLADAGADVDKVDSSGWTAREHAALRGHLPIARLLAAQCRVPAGMTTNSSDDERPTTEVALPHVVASLEERRSNGSSRPAEPVKTFGHRYLKNESLVLVSLGSMDMRKNTEAVKLDKVPLAEAHTTQLDTALSVVVSAHGAHGEPTVIDLPVHENIATEPIVFTTTDPASVKLLFDIVPTYSGNEKSKIGRGVALLSSVRPTIGTKRMNLQGDVCVPMMGANLEVIGTVNFNFLVITPFSHPKMEVTSRQTYWRKLTSTMVIGHRGMGKNMTSNRSLQLGENTVPSFIAAANLGAQYVEFDVQLTKDHVPVIYHDFLVSETGFDAPVHTLTLEQFLHINSDSSRSGSSAKAQHKQLKQARSNSPGPRQRSMSMDYPTKETGMDERMKHTRDFKEKGFKGNSRGNFIQAPFATLEDLFHKLPESVGFNIEMKYPMLHESEEHDMDTYAVELNSFCDTVLTKVYDMAGDRHIIFSSFNPDICLCLSFKQPSIPILFLTDAGTCLVGDIRASSLQEAIRFASRWNLLGIVSNAEPFVNSPRLVRVVKQSGLVCVSYGVQNNDPKLVQRQVKEGIDAVIVDSVLAIRKGLTKDEPVAASLGEKVTEVAVRNGGSHASSNGVANGGQKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT21</accession>
    <name>A0AAE0NT21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="83088" checksum="A85A0F830182C5EE" modified="2024-05-29" version="1">MQMKPGRALSSRWLRRVFSLERNGSISELPLYLCPAFRSPSAQQSLRCQFGKNAPSFQTRRLHSQAAYTARDTAESYQLITRHALKTLPAQCSGCGGLTQTAVPDQPGYFDMSRKVVQQYLGPATEQEEGPRKYGQVVEQALQGVDMEEMERLGVDLKALLPDPDRVASRSESRRAAAPTQPPLCDRCHHLVHHHTGNPIYHPSIEALRDTIDESPYKYNHIYHVLDAADFPMSLLPRLNYLVDLTTIRSKNRRAAEYKFHRGRTTEISFIISRSDLLAPKKEQVDAMMTYLRETLRASLGRIGKNLRLGNVRCISAKRNWWTKELKDEIWERGGAGWMVGKVNVGKSQLFQAVFPKGRSDWKPPKDKITIPVFAKPSSFSGPESDAFAKLLPKPVRRVDEDEALLPPAQPETDYPAMPVVSSLPGTTASPIRMRFGGGKGELIDLPGLSRGELEDFVQEDKRSSLIMKSRVTPEQQILKPGRSLLIGGFIRITPQTPDLVFLTYAFTPLEAHVSATPKAILVQEQSEEAPKVENIALPGVGEKIKLAGSFKMRYDVTKARAGPITRRNAANIPVERLPYRIFSIDILIEGCGWVEIVAQVRTKQLYEPPSSSTPPAPTASKKPSLNKEAEWDIYRLETLDLSEPEPEAAKAEEAPHKFKDMEGEGEENQAEDAGLEELNYPVVDVYSPEGRFVAARPPMNAWLMNQPKNAHLKSRPRKSMKGVKKMDKVARRVREAGSANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT86</accession>
    <name>A0AAE0NT86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_147102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT86"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="601" mass="67903" checksum="0D98B9CC74C539EB" modified="2024-05-29" version="1">MWWDPETIEAAVTREFVCSHLLPQEIERLDRPLGFGDGLTDGTYWEWIDQKAKCIFLILVDLGIPDQIFGIIDDSWDDEDLPIALDQVERLALTPAKDEKSERKFYYRQFYYLLRPLQKGEHMIYQDNEVVPLDVVDKKQSLGPAQGHYIDKVVLPDQPGTVFCRRRIPVGPGFGPSYLSHEDFLFEVNGIKNVQNEHLVSYWASYVHQGYGYVLFTPAADFTLKSFLATTPNTVKNMDKQERRRTVLNWIHCLVDTLCFIHTRGLSHGNIKPSTVTFTNDNHIFLSDFTRFNPESLAAMMDKTSFDKESYDYAAPEQWFRPTSGPPSPTHRRATLTSFSTSPESNHFTISRVASDLHGPTSPMAMMHAPTPHLNPQAADVFSLGCVILELLSFLLKKHGRPFATHRAAKHKTPGRGGAVPDSSFHKNLGQVESWMTQLAKDASKKDDPMFKGISPMLHVVERMLAFHPSERPAAHDVQTKLYQILTGACGITEPHCVHRYGGWDFGIGSLKLSSPPLSRNNSHDTMSIATKRSSGSRSVDHKRTGSGSSLRRADSFSRDPERERERTRTASELSSGFQAIQSLRIRDKVRPWQSPAYAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTC6</accession>
    <name>A0AAE0NTC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_150026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="446" mass="49614" checksum="D0FB763A637B9543" modified="2024-05-29" version="1">MPYDADSESAGSSHIYPETPSSTSNDESAHLRENGSRLHVQPQQEASDEPHNGFENYFGREIDDDEFEYEENTDYDLPRPGDDTQSPTPPQDHLPFQTGLVPSQRSSQVAVLLQSSPPKDAFARLPDDVLLSNEDDDEGSQGHLVASDLVPTPNFYIGVPVSRASLVPSHPDREPSAKPSSAPPSLPPTKKRGRPVGWKAGSGSYSALNGNISEPQPKIRKTPGDLKRRGRPHKLPAPTPREIYLGLSPKWVPFYCEWEGCPAQLHNMETLRKHVAIVHGYLGVCKWAKCANPPPEIEPRHFTREEFAAHIAKAHLLPFVWHVGDGPQNSATLDNATRMMGDADPLPPYLFDEDGNQVTPSIKGQEFEDDDERKRKKHRLYQLMVDRDNNAPEEPQYTQAQLDDIADADAAKKAKQKMFRSYHDRIMGGSTGQISPYNPLVRGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTF8</accession>
    <name>A0AAE0NTF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_469875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTF8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="36422" checksum="8F26BC56B24376DE" modified="2024-05-29" version="1">MSGEQSLYCHGCHHQWQADGHSIECPTCHSSTTEIITPDNDPRHFHNGHPSTQAGAAVNSDDTMPSDSQPATSAPQQPQVTAGNNNNVNNNDASTQHGNTDPSAPANGSHPPEIRFVFAPQITFFTTIVPQSSNTPSGPMPAFFSFPLQFFTTHPLMPSENSSSPPQGASAPTESATTPSENANRPSESTNTTAENASSPPPGSGLGPTFLAAMVSSIFNPANAVFGDAVYSEAALNAVLAHFASTPQGNRPSPAPQTAIDSLKVKELDEDTQCAICLENMAKCDKATVLPCSPKHVFHGECVNTWLKQANSCPQCRKPLAGAASEVSKPPPSPLAEGQDRQETATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTG5</accession>
    <name>A0AAE0NTG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_558919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTG5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="69"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="702" mass="79895" checksum="40190D04E3B0B19E" modified="2024-05-29" version="1">MSAPSRIYADLPLRTSRQIRLLKLEWKKEPFLLRHIPAFRRRRMSSSINGYWRLDCTITVASLDDSPDFHALSYAWESQAATEALICNNYELLVTRNCCSALHSIAQDEWSRSCFFWVDSICIDQDSIAERNHQVTLMADIYKTARVVDIWLGEADQDSLGALKELEFLTWLAKADRVQGDRRMRALQKIRKDQVSSVFKDRNLALPYILVPEDMVSFTHPLSPILGRTWFGRLWTLQEIVLASVAVVRLGAHSMTWSDLCDVDNQITVAEVSLGLTQYPSDIFQRVRIVADLRIILGMEEGLRYGRRWQYNLPHDHPFGPISMKRVDPLPRSSIGPRFFLSCKLAAADPRDKLFGQFGILQEHGICLATPDYHKPLSTLYQEASRAIITHDSTLELLYFTCTEGGSSGQNLPSWAPDLSYDWFPWIPDWAFTAASQATEARFQFSECGSLTVYGVPIDVVIEQTRSIDTTMPNTDWSTYPTLNRNEYVSKPKYFRKFIPVMESLRSWITFALECHTEQTEHAHGLLCQVLLQEVAQAFGADPEKWTRLQGRFSIWCELLKATENHEMEWESEPRTGLISEVLTKSSPATGDDYPDSGLELLVEQLYNQLILDDTSRTVHHIVLTRAKGNCLFRSLAGKLGIASRKIQKGDEVFLIAGSALPMILRRRKTGYRIIGPAYIPGVMQGEMWPQGGQGLTTLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTI2</accession>
    <name>A0AAE0NTI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_448096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="150" mass="15972" checksum="261F5B2EEFED9ABA" modified="2024-05-29" version="1">MSDTARWKATVYIGGLAPVVTAASLHDAFIPFGEIADVSLPKNENPNATEPHRGFAYVEFEDAEDAKEAIDNMDQAELFGRAIKVSAAKVPKSATQGGLGSKTALWEQEGWLAENAVSEEDRMAADQAQSSIPDPMQGLEGLDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTK5</accession>
    <name>A0AAE0NTK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_412655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTK5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000051">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="834"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="880" mass="95039" checksum="9DA078BD2FC78E13" modified="2024-05-29" version="1">MGIKGIYKEIGPGERISLCKLAVEQLEQTGRPLRIAIDISIWQFQVQAAKGGANPAVRTLFYRLVRLLGHAIQPLFVFDGRNKPAFKRGKRSRGQGDMVSTTMMKRSIRLFGFSIHDAPGEAEAECALLQQQGVVDAVLSEDVDTIMFGCRRTLRGWTSEGTKGSKIPTHVSLYDTAELAKGESGLDREGMVLVALMSGGDYIPEGVPGCGIKVACEAARAGFGRDLCRIKRSDKQALAAWKARLLHELRSNESGFFRTKHKALKIPDDFPNMEVLGYYTHPVVSRQATVDRLKREFPSAVAIDVAGLRGFVSETFDWTSLAGAVKLIRVLAPSLLVQLLLERQESQETQDDHVLKQEESTLVKSIFKSRSHFSTDATPELRVSFIPADIVRLDLSAEIVEEVEAYGRTGIALNDDEEFDDETIDDQQESGGSKKTFDPLQPDLVWIPESVTKLGIPLTVETWEEKQRAKDAKAAAQAAAKAAKAAKTTTAKTTRTSGKVRAAKKTDMPAGALDKFVKVTRNITADAPRKSAPLIVDSLASNSIPAPRSSPGIGSHPVAHPTPNEASEQPAPKPSRKSQQPNKSSKDRAGKPAAGANPWTLSGSQVSPKVTRLISTSAVASKSQPRSSVEPIIISSSPAVPEVASPLRSSAGNPEQTSPTRKWSLSPPPEYSLMAHPLSPSPITRKLMEVPAVPSSPQPARKARPFKRAKSGADENTGTRSTQTSITSYGRLLKGVENTYRNDKAATPNNILPAGKLGTSADGEESPLPHPTKKFSGSRVDNSHRSPRPILDIGKDFRFSDDDDDDDGDENDPFGSPLALPGLPSFLRPKDSSRPQSWNGRAQQQSLPTVISATSAAATIGGGKIWSQNGDMGVIDLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTS6</accession>
    <name>A0AAE0NTS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_159348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="97"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="21315" checksum="D7B827516C744471" modified="2024-05-29" version="1">MSSPYSSQYYAASGALPIPAGKGQYQYPTYYASNDSTYSVSPPEDPDASVSSESGVASYGNSGYSVTTSSYAGSSQGEYDSAGSVSGVDLNEYMQERFADSFNPIPLDKCTVTQAQTSGRLNDKHRQLLEMQAMAQARLAKSRARFAQGLEDAREVRNDLEWTQKKVTSLKAKASKKHSKEYTKARARYPSPDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUB1</accession>
    <name>A0AAE0NUB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_160731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUB1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="396" mass="43806" checksum="AA3618B7FD97D2C1" modified="2024-05-29" version="1">MANIPKPGPANLRPGAGLDEWLEEAKQCHYLPEPVMKQLCETVKEVLMEESNIQPVVTPVTICGDIHGQFYDLLELFRVAGGMPGDTAVQAPKTATTVITSDNIEAPTEITNPKLKSKIRSTTAPDEEIEGDTTIALSADGSTSNPSETAQSHNAASPSADTRFVFLGDFVDRGYFSLETFTLLMCLKAKYPDRIVLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDFLVLAAIVDGTVLCVHGGLSPEIRTIDQIRVVARAQEIPHEGAFCDLVWSDPEDIETWAVSPRGAGWLFGDKVATEFNHVNGLTTIARAHQLVNEGYKFHFEEKSVVTVWSAPNYCYRCGNVASIMNVDKDLKTEFHIFSAVPDDQRHIPANRRGPGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUW6</accession>
    <name>A0AAE0NUW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AhpD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_500972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUW6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3388040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="607" mass="66766" checksum="D96D9B4735AFD925" modified="2024-05-29" version="1">MASKAQPSPPPPATVQLHALSAGHFSLPEEQFVYPSSGARSTVPSLCFLVQHTNPATGIITRIVFDLGLRRDVERYSEPIRRHVATRQPMTTTPDVVTSLQAGGLTPREVDYVVYSHVHWDHVGEPRDFPGSKFIVGHGALDLLQGTSSKLRGGHSFFEADLLDLSRTTELIDPSDTQPKTGPQIKFSSLGGETVNVAGPWKPLPEFDLPAVLDIFQDGSVYIVDAPGHLPGHINLLAQAPGDGGSRWVYLAGDTCHDRRIMRKEKEIGEWFDKTGQVCCIHADRAKAEETIERVRGLEERGVEVIFAHDVEWESDVGNRGRFFGALSSVHVVETNDFLSVFILPIVLKSQLKEDFIARLGAPALHSGWASLLSIDPEFFAASVSLAAVPRQKSHLSRKHQSLIALAVDSAATHLYTPGIRAHVTSALKEGATLPEILEVIELSSTLGIHACNIGVPLLVEVLKEEGKYTDEITKPFDDRQEQLKEEFTEKRGYWHTFWEDFLRLDPEFFGAYLEFSSVPWVKHVNGDKKGALEPKMKELVYCAFDCASTHLYVPGLKLHMKNALGYGATPQEIIEVLEIATLLSLHTAHVAAPIIAELTAAPSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX07</accession>
    <name>A0AAE0NX07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_518403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX07"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="553" mass="60820" checksum="82BA62D759038FFD" modified="2024-05-29" version="1">MQGDRLGFIIGLRDLVPLEDVLGTCWKPLFHSTVIAVGFPIPPSHGTHGIRIPFDAILEMAGILYDVALEDEDGNNAGVYFDGIPHTLYPTAYIKDHNTIQWHLVSKGRLSEGSDDHSIAPDSGERPGWERISNLDTLTRSTEILGYCSNVQIQLGTAARVQYHNNILPSLSTVERPPVEIAGGSGTVGFSMFGFTASKSGTWRPRKAQQVSRDSKELDDYAMRRGLQDIKYAEPWPDGGAEVRRVLAGDPQALDYSYSNREAVEKVLESNKGKQIGNIIEQIWGSIQKIKIENGRSDLGSCGIFPLGRTGLAGWDWLELADLALPTISKQELVPRDVPRVGKTRREVMEIAGGTPRLKDPPSWVAFTKTVPIFLGRDLGELITPTRPAEVCRQWHPMPSSLNNLYLEASMRCIQALGQPSGNLHRQRWVFFNESKWELGGVDIFQPCAACLDDPTLCVKHPQVLKNERKKVVNVLWKAPPASITAVTVAATAGQQPLAAPLNQPATPQAGVQILQEASNDGAVVFSLERKPCVSSELGGVRGIKFFFLRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXA2</accession>
    <name>A0AAE0NXA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXA2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="325" mass="37160" checksum="F63790F7327B356C" modified="2024-05-29" version="1">MSQALANPNAPPSADMQAKHKLYYRLFSLKILRPWYISNVSLVKRVDRAIRIPPYDYFWVDIDKITRIVTFGLGPFDIALPQPALVWESRVQSNERDPAVLGGPSLALLESSVSCRVLYRHHEMIELALYYPYAPNCQRRADSPLMDLFFCDPRYTQEMAECLEIAATDANLAIRTRAYGVGTNWADTLEIAMSKIDRNTLVYSSQPNFPINAIMNMADPGKKPAAIFWDDDLADTASKWHHPTCSYVLKPAAQWTSSWSLHIHAKKLTNGVLMANHDSWGYQKFCLDTSMNDQDRFREFMPNSSAIFIRKDLHKPSAWLPELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXM8</accession>
    <name>A0AAE0NXM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_537638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="723" mass="79310" checksum="BD5E6ACD9DB50A64" modified="2024-05-29" version="1">MTKHHEIPDHISDRIVELCTSSESVSSLLAADPTLAPGDAWTRLYGRHALKSAARTSAKANGIATLHVERQAEDRLELAAKCGKWGPTQPSELFLQIYHDALCTLEDDPLHAMVSPSLMGSCGVVPLTVISVVPDIVRHMSNVIIRAEREVFLATNYWQDSVASKFLTDAIRELDRRAGKRGTKIVMKIIYDRGSPKQLFEPHYIVSEKEFTGKNVSLPHPSEIPNIDLQVMNFHTPLMGTFHSKYMVVDRKIGILQSNNIQDNDNLEMMIHLEGPIVDSLYDMALISWHKMLDPPLPSRNTPAAQGGLGINGSPGISDPARVPPSAGSNGILPEPGAVDPSAPAESSDPTRADILTGPSTTQGVTHPHPPQGHPTGQESVAGNIQHPVRSTALNGAADLPAEHFLTKGEQSIPQSQMQEPSPPDNLLPQHNADDPHYDDDIAGEVARVQTAVSPKLNGETRMEAVTRLLNHTVSPGFEGDAPECPPGEEMTPYIAHPAQEPFPMALVNRSPHGAPNHKSVSNPQNAAWLSALRHAKKSVFIQSPTLNAEPLIPAIRDACERGVDVYCYICLGYNDAGELLPNQGGHNEMVAHNLYRSLSEPARQHLHYFWYVAKDQTKPIVQVRKRRSCHIKLMIVDEHIGIQGNGNQDTQSWFHSQEINVMLDSETVCKAWIDALRRNQNTHVYGALVKQDGVWRDKDGNEAEGVIGVDPGDGWVLSLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ65</accession>
    <name>A0AAE0NZ65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Got1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_113669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ65"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="14982" checksum="0E0A269DC02A1FB6" modified="2024-05-29" version="1">MPTMWLSDSQKIGVAFCSGGGFFLVGGVLLFFDRSMLAMGNILFLIGLTIIIGPAKTLLFFARKNKAKGTAAFFAGLALILFRWPLIGFLVELYGIFILFGDFLGTIAGFATSVPIIGPYIAIVVEKIGLARRNTDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZB0</accession>
    <name>A0AAE0NZB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_389961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZB0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="156" mass="16570" checksum="884176BE2BF896CA" modified="2024-05-29" version="1">MSKSRAAGAVDQVVKLIVGAGQASPSPPVGPALGSKGIKSMDFCKEFNARTQALIAGTPMPVRVTVRPDRTFHFEIRTPQTSWLLLNAAEVPIGKKGKRRGASAPGKETVGTVSLKHIYQIAKIKQSELRLSGLPLEGLCRSIIFQAKSIGISVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZE7</accession>
    <name>A0AAE0NZE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_465651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZE7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="44"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="45650" checksum="11DEEEBFAADA280F" modified="2024-05-29" version="1">MMRLSVRLPSLAATTTRLSGGKHFHRHRRLFSSTACRPADFTHAVIGGGVVGLAIAQELARRGGPSSSTVLLERHQAVGTETSSRNSEVIHAGIYYGAESLKTALCVRGREQLYALCAAHQIPHRRCGKWIVAQNDTQLEALHRIHAFCSDEIHVPVRWVPRDEASRREPAVRAEKGVLESPTTGIIDSHALMLSLLGLFEDAGGTLALGSAVEAITPLGRPLGSGGWELRVRDAVSGQTSTITADTIINSAGLGAVDVHNMIVPEEQRKEMFYAKGNYFSYPASSPKVQTLVYPAPEPGHGGLGTHLTMDMAGRIKFGPDVEWVDSPDDLAVSTARLPQAIEEIKRYLPGLDETLLQPDYAGIRPKLGKLGAVMHGKGFVDFVIRKEEGYEGWVNLLNIESPGLTSCLAISEKVKQLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZQ7</accession>
    <name>A0AAE0NZQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_390608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZQ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF40">
        <property type="entry name" value="DUF829-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32237" checksum="90CF9BC49B2A868B" modified="2024-05-29" version="1">MATKAKPLSFMERLSPQVSIYRPPASSLSSNTNNHGSPKLILLASWTDAIDSHIVKYIAKYQTVYPASQVLLIKSTTRVFFKPTRIPEVVAPAIPAIRACFPEPSSSTTPPELLIHIFSNGGSSSIASLYQAYAADAASATGGDQDPLLPAHTTIIDSAPSVYTAAEAVVFFTLGLSTIPRLLALPLIYAVTYTWGVLIATGWLGFRDWTRIWGDAHNDPLKNKEIRRTYIYSEKDGLINYKLVEQHADEAEAKGFEVRREKFVGSEHVAHARKDEGRYWDVVRTTWEGAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZR7</accession>
    <name>A0AAE0NZR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_123262</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZR7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="290"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="595"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3390783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="677" mass="76250" checksum="515A17AC61CD1E51" modified="2024-05-29" version="1">MDNNGNRLYLNFGNNNDRLAATDRTYPTTPSTFPQPVFQSGPASQAPNPSGGAQQPQSQQPQGQAQQYPPGYASSSNYYVPQPQQQAPPLPKQQQQPLPQQYAPQYSSQLSAQAADYSSASQGYSQPRSNTPGTSNDPNTGLAHQFSHQNLGGAARNLQYGARGPSPSQRPRTAGATGQQPAYGSYLNAPMPAPPAPTPQLEFAPAPERNPDKYGPNANNNQKKCSQLASDFFKDSVKRARERNQRQSEMELKLGETTDPRRREALWQTGGRKEGSYLRFLRTKDKPENYSTVKIIGKGAFGEVKLVQKKADGKVYAMKSLVKTEMFKKDQLAHVRAERDILAESDSPWVVKLYTTFQDVNFLYMLMEFLPGGDLMTMLIKYEIFSEDITRFYIAEIVLAIEAVHKLGFIHRDIKPDNILLDRGGHVKLTDFGLSTGFHKLHDNNYYQQLLQGKSNKQRDNRHSIAIDQINLTVSNRAQINDWRRSRRLMAYSTVGTPDYIAPEIFTGHGYSFDCDWWSLGTIMFECLVGWPPFCAEDSHDTYRKIVNWRQSLYFPDDIQLGVEAENLIRSLICNTENRLGRSGAHEIKGHSFFRGVEFDSLRRIRAPFEPRLTSNIDTTYFPTDEIDQTDNATLLKAAQSARSATTGVAPGQQEESPEMSLPFIGYTFKRFDNNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZS7</accession>
    <name>A0AAE0NZS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_121257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZS7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3390647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="272" mass="30183" checksum="D5490BA7F0555C2D" modified="2024-05-29" version="1">MSPSATASANGIANNGQDVPDVADVPNPNTFITGAWTVDKVLDAIPTGRLAEGTTSPLPYFHILERLKTTKREGWRRFGIKHGESIADHMYRMSLMTMLAPPSLSAKLDMAKCMKMCLIHDMAESIVGDITPVDGVPKPEKSRREATTMDYITQGLLGKVNGGVTGPEIRAIWQEYEDSKTPESHFVHDIDKMELLLQMIEYEKRGEGKLDLGEFTYVSTVIVLDEVKAWAAELLKDREAFWDGHAHVRGEAGVDGGIAPEKKEMQDEYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0P3</accession>
    <name>A0AAE0P0P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0P3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="182" mass="20283" checksum="A21A9504A3ED3F3B" modified="2024-05-29" version="1">MAPPSFRARIHDERHDELDIRHGIDGVEPNPRAHHILGAVPLRGAQDYKDDDSDARNVAEEDTQNETTRPVPDARPPDVREKILAGRGQRQERKSGQFSVVYFLKNTKCWQKVKTLPSGAFLSVTAKLAGRTVDTNRLALRVLDLAYLPRPNSGAAMPTPTTTLPSKRSRWDDRAPSSTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0Y6</accession>
    <name>A0AAE0P0Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_390389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0Y6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="102" mass="11174" checksum="46537A00B744BA8E" modified="2024-05-29" version="1" fragment="single">ADGTRGKPCCATRRCNIFCCSCGGHVLGCCSQPVLTTLFNAWQPDEVNAFRLVDVEGKGNVTVIDYLSYMNVEGEPGIWVEWFRKHDANGDGVITVDELCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P438</accession>
    <name>A0AAE0P438_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 CYP542B3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_498465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P438"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="530" mass="60005" checksum="5E433F331A87087A" modified="2024-05-29" version="1">MPSTCSDRLKLPKASTNRSGLLATYTLYGAIWRLYLSPIAHIPGPKLAALTWWYEFYYDIVLGGQYVFKMIELHKEYGPIIRINPDEVHIGDADFFPQLYPASNRRRDRPRFFTKQFGSGVGTAEHELHKLRRAAINPFFSSQSVRNLQPVIEERVNALLDRLQKDAKTPSGQPLNVLYPFSALTNDVINEYAFARCDHLIEDPTFGKEVTDNLLTGTHYGKMIQHVEIILKFINALPESISSRAVAGWSGFLKMKHDIRQQIAEIKATEHTEKWELDVSHPTVFHKLLTTKILPPSEKTITRLGQEGQVLVQAGTLTASWTLTLATFFLLDRPATLQRLRDELVAHMPDPNTIIPLADLEQLPYLRAVIKESLRHSLGTSGRLARICPDESLTYTDPATNITYTIPPGVPVGMTNYKTLTDASIFPDPFAFRPERWLGDDQQRLERYFTVFSAGGRACLGLWLAQAELCLTLAKFWRVWGTRADPRPGDVGTVRLFQTTARDARMAADYFIPIPWKGTKGIRVILQSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4I6</accession>
    <name>A0AAE0P4I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_16083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="405" mass="43696" checksum="C52CF7374C6D179F" modified="2024-05-29" version="1">MAPFPPPPVNTIDWSNVGFRVREVNGHVESHYSVQTGKWSPPTFVADPYMRIHGMAPALNYGQQAYEGLKAFRLPGDDKIAIFRPDRNAARLQHSAAFISIPPVPTDLFLEAVKAAVALNAEFVPPHATGAAMYIRPQIYGSSAQLGLSPPDEYTFCVFVLPTGVYHGSHPVKALIMDDFDRAAPNGTGSAKVGGNYAPVLRWSDKARNEGYGITLHLDSRRHEEVDEFSTSGFIGALVDGEDVTLVVPDSKAVIDSITSVSIQDLGRSFGWKVEKRPIKYSELPNFTEVMAAGTAAALVPIRSITRHITDATSSQSLAASAEAKAHPRVVFQDGQETVTYIAEGVEDPGALCSKLLAKLQGIQLGKLADEFGWRFEVSEDDGKAIVSSSSGQANGDDQTVDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4W8</accession>
    <name>A0AAE0P4W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_7445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="629" mass="69437" checksum="858D95301661CBDB" modified="2024-05-29" version="1">MPMLKDPSKKYKRFPPLNLPNRQWPNKTIDKAPRWLATDLRDGNQSLVDPMNGEQKWEYFKMLCDLGYKEIEVSFPSASQTDFDFTRRLIETPGIVPDDVWLQVLAPCREDLIRRTVESVKGAKKALIHIYLATSECFRRIVFGFTEEESIQVASKCAALVRSLTKDDPSQSGTEWQFEFSPETFSDSSPEFVIRICEAVKAAWGPTEESPIIFNLPATVEMSTPNVYADQIEYFCSNITEREKICVSLHPHNDRGCAVAAAELAQMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGITPNIDFSDLNKVIKVVEACNKIEVHPRAPYGGSLVVCAFSGSHQDAIKKGFQVREKEGKDFDDHWQIPYLPLDPKDIGRDYQAVIRVNSQSGKGGAAWIIQQHLYLDLPRGLQVAFAKVVQKIADERGRELLPTEITELFRQTYFLNKNPRFSIVDYSISNDRSSSPAPPAPGKTQDTKNLMRMFEGVVSIDGTEHKLRGRGNGPISSLANALRTIGIDLDVQDYKEHAVGRGREVKAATFIECIAAGTDEKVWGVGLHEDVVQSSLSALLSAASNFALSRQGSPVVSQAVPDIGINGSASLKPLDATNGSAKIPTIIEALDAKAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5X2</accession>
    <name>A0AAE0P5X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_555196</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042146569" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3393899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="25861" checksum="A0E10F8212641BB3" modified="2024-05-29" version="1">MKLIIIVTAAAAGVVMAQSVADLPPCGKICVNNMLAQAPELDCPIVNGQPDPDCLCNQLNFGYGIRDCAAQACLPHEVGPVISHGLAFCANVAAPTPSSASDGPSTPGAPEATTAPAVPAAVSAMGGPNAGVVVTGASDGSASAASDGSLTLRTAVVVSTYTSGNATLTTTLASVTEAVSVTASSDGVVSTKQLVASASADSTVTSVTTIPSSSRSTSRITRTSTTTASSASSSVSEAVGASMPRATVVKDSLFAGAAGIAAVMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P640</accession>
    <name>A0AAE0P640_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Borealin N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_33255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P640"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="402" mass="42627" checksum="E37927747ABEE119" modified="2024-05-29" version="1">MAPPRGRKRKSNESTMSNNGEQHAHYMAGSPQKVPTKTGSPSQHQECSPAKRRKQGTITLAQKQALIDNLQLEITERARKLRANYNIHAQSLRTRIEIRVNRIPISLRKVKMGDLLQKYSTDQPQQQQSQQSLSQYPRTALTSGGGNRGPPVPAKDAVTRRPPLPSHVGGSASPMRLTKRLSHEISSGDKENDVEHILENPKKKARGGAHAGPASADIMRNPGQILSPTSSNSRIAPRERERVAPTPVAKGPSSGIARPVSPTKMAGGGGLISNMVEKARSTRAAATARKTTTSTTASSSNGGTTRTRRAAPAPAPPPVARPATRRRASGTSESSDGSTSTVVRKRPGTAMSTTAPKAAPAKRTVMSTIRKGVVASTTKKAPAAKAALAATTGTGRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P663</accession>
    <name>A0AAE0P663_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P663"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1262" mass="143502" checksum="0D90B9189555DA5A" modified="2024-05-29" version="1">MSSSRLSTGMSNSTGRASRTDSGYRSLEGGSSGSKPTLVNTYNENVGRKLRWDDSPYIEPSRDLQRVQRRTEVIDAGGRRSPSPPIRRSEVERSNERPGDYYFAPPRPRAPEESLNPKNEVSARNVADSLPMPRPQSPNRRVDLVHDPSDVKAKDITVELEMPVEEDFEHDLEDFCRLTRLGRFKDAKKLYQEQLGHLGTRPYIIIQYGEMLIASGDYKAFRNLSYPAGLLQSQTGSSQATDQSHNKLFANFELLKLLSQPRLPHFAETALRVVQDSFQALGSEGVMGSTEIQLLTLCLKVLRYLQTCSDERLIRDAKIAIRDRVDFKWLYHELLHEDRIWDFKDLLEAAVPVFGWADTAIHVFGTSSFPTVLETISRDWSQPTYDESTALGLLDLYTSLILQDPQRGSKNFRTSLLFQHAKPLAELVQANDAELMRTRPFIQWILARSVLEMEAVPQRPDGIRLEEFGGLSIQHGSGVHLPVYVPRRHSDKPDWDMFFIRSNAAQRLVVEVALQAARHTGDYTMEATSLKLLILQSQDPKRSMDILARLQLDTQDDKEGFLSTCLSKYLVPGDVNHGANIIQDFARLDKESNGSYLSIGTNAPLLWARSMIHGFLVTSDPAAEAYSNQIGIMLIGPEELCKKQIKAYGPRLPVYITNFVKENFHQIHVPLAMETIPFKLPPKADRHEPARIRIEERARVPSRAPTLDPLTERVGTRIRDPVRDTARESVRKPVRRASSSSYDYSDNESLDIRYTQTPAEDRTPGPAYRSRRPPPPPAPHYIRTVTRDVRDHPYFQPETTIIRTRARSAERRSSPPRGPPPPPQAQAQAQPVVITNRITKNKHKDRDSEYSSDESIDIHVRNVMARDRNPQAPDTASRTTQNAPEQALGQMAPIVINNRITLHSDSESYTDYSSDELSQHMPSHRRRHHHRRRRSSSTHSYVDEAREKWELERTREQLRMLQASVQRKEEQDKRIKGEVELIRTKDELNRLRQEEETHKLEQRYKDMELSRLKTELEQFKRKAEQDRKSDEKSRGSLGEPAVRTPSLKTSRDIGNKSKPDPGDFSYESAHRSFKSRVYTIDSNDAGGNSSRPSSHSKHHSRRRKRTVDNWEPESLGPATKEKGSEVTEQRPMPTPSTKVSLDSNSPNVEEVVELDVRAAPDNNDTIGDGHVGIEEANRQTASPKLLPIHPPPPFESGDVDDGRYVKEAEPMYEGWFHEIKLDEDTAEKTAAAVEAKEEPPVVSPISVVQDQDALEPYQYDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVT6</accession>
    <name>A0AAE0TVT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_524123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVT6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="20787" checksum="BF868D05C6F9C653" modified="2024-05-29" version="1">MTKTWDDNRKTIIRIYKDENKPLHEVRRIMEEEHQFKASTRAYRSRFVRWGIRKYTSRKRPDSSNTAKNRPPSDDTSLSPSSREDDDGRSPPTESPVMTSGDYFGSDSLGYSMKHDSTYTRQVTAPVPSIAGLPSSPMEFASPDQPLQYPMQQFGNPQQTAVEDYPLLWRHQVTGIMISPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVY9</accession>
    <name>A0AAE0TVY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_475545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38831" checksum="C97B38CCE5E66D9F" modified="2024-05-29" version="1">MARCMLQLAQPTFPRIGPLVETNPGSYDVLGRPITLNMNNMVQLSNIPQSIFPPQRSTYKTADKWYVVFADMQMTTLLLQHNDMVSSEDDCRTKYVARQLFRRLAKQDRLSKFGFAEDDWSACSKKRDCATLSSPDGSGSFRLWSDDFRPVNVLIDDSDEVLGVIGWEFAYVGPTQFVLDSPWWFLLDVPEMWDDGIEDWASVYDSRLRTWLSSMEEAEKDVSPGSLLLSAHMRESWDTSRFWLNYAARRSWAFDTIYWKYLDEKFFGEWDKEILTEELWKTRVHLLSEEEQEVMEPLVQTSMEESKEQVLVEWDAGRQSSTCLPFCSTRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U004</accession>
    <name>A0AAE0U004_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_187851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U004"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042222472" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31077" checksum="D757A7552A0AB6E9" modified="2024-05-29" version="1">MYPSHAVSSLLVLAGFLSPALALSKCACKKNPVLSVLSAAETASEFCSTFLGIQTQTVTVSPSTTVSTVVVALETETITVPLTATASTLVTSTKLSTTTTTHYLRNAGGPAQRRRAIVDREVPPGLEQFPEVAISTACSCYIGTTSTSAATVTVTSAYATTETSTSTDITTITVSPTVTTTTATAVTETTATSTVTVEQQLTYVARYTSHCVPYNYQTLDFGLTAPSLTFEVAFQLCAAKCWSYVGCTQIYVGYDGGSNFDCMTGTTGSFGWDASEFQCNYPPIHQYGYWFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0G8</accession>
    <name>A0AAE0U0G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_415317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0G8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="143" mass="16940" checksum="753A64C78F1F7E51" modified="2024-05-29" version="1">MGSIVLPHLETGWHVDQAILSEDERLVVIRFGRDWSADCMRQDEVLYRIADRVKNFAVIYLCDIDKVPDFNQMYELYDECTLMFFFRNKHMMIDLGTGDNNKIKWVLEDKQELIDIIETIYRGAKKGRGLVVSPKDYSTRHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0I4</accession>
    <name>A0AAE0U0I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_501654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0I4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="854" mass="94884" checksum="2099639580B0E279" modified="2024-05-29" version="1">MDKLGLDLLNLDLDERKAAVARPVGAQLWRLLCVYQIFGANTDVGKTVFTTNLINTVTENRPNAKVAYLKPVSTGPKSKADNIHLQTYTLPTVMVETKFQYDLESSPHTAAEKEFLLTGVRIPGDSEITGHIREFSRGFASPSKPGWLFVETAGGVHTPSPTGTSQAELYRELRLPIILVGDSRLGGISSTISAFESLKLRGYDVVMVLVFRRMSDTLVNHKYLADYFEEHGGVPVVTYPAPPEHVGVVAFERYNMREYYETASRSEAMTYAVKVLETYHTNRLAQLQSMSREATEVLWYPFTQHIELTPSNITVIDSAWGSYFQTLVRTGDLVTRYLERLGLLESTFDGTASWWTQGLGHGNSALALSAASAAGRYGHVMFPGMVHEPALRLAQELLDVVKNPRLTRVFFSDNGSTGVEVAIKMAMRATRMRYDIEMTEDTNLGVLGIKGGYHGDTIGAMDCAAPGHFNEDVEWYKGRGYWFPAPTVECSQGIWRVLLPNEIKDISDTPEVARYTFKSLEQVFDLQTRGVLALSETYKRFIVAKLKALAEEGYKGERNFGALILEPVVLGAGGMQLVDPMFQRTLIEVVRESAADIFYKDRMQSGFAELGLRDTAIWKGLPVIFDEVLTGLGRLGRMSAGSFFGSTDTNADIVVHAKLLTGGLVPLAATLASESIFDAFKGDYASSGLLHGHSYTAYPVGCQVALDTLRFFKAAQTKAEEKLAAENKEAENDMTESQKFYQHLADEAEKEPPKRAPSVWSSKLIHFISNQPSVAGVWNLGTILSIRMKTRYEDGKYTSQALMLQQELAEKKIHTRRLENVLYVMASLTAEAPEIQEISNEVERAFNHLQWEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0T5</accession>
    <name>A0AAE0U0T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_139620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0T5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042007970" description="GMC oxidoreductase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="510"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="70901" checksum="D6C1F7154C7B8FFF" modified="2024-05-29" version="1">MMLSAHRSRSFLAALAVTFLSVFGQASAGSKCNGNLYDYIVVGSGPGGGIVASNLALAGHSVLLIEAGRDASDDLSTKVNALYYPQSLPLQWSFFVKHHSDPAVEERYRLLTWTLEDGTYWIGPKAQAPAGAKLNGVWYPRGATLGGSAIVNAMASVLPNDADWNKIAAVAGDDSWSAENMRKIFVTIEKNLYLRPNESTAGHGFNGFVNMGQGDSSYYLQEPGRLALLSHLAKDLVGAEVDQAAALDYLERDANFLGASRDQSAQPYGLPNHNNNKGRRWTTRDLVLDTVAKTPKLKLALESLATRIIFNKSGPTPKARGVEYLEGAGVYGASWQYNPATAPKGTKKKAYARKEVIISGGVFNSPQLLQLSGIGDATLLKSLGIPVISDLPGVGENLRDNQELPVAGLSPLNITSVGGNPAWATCTFGAPGDPCVAQWEQGTGPYTDPSGNSECSFVKTAHSPDGNRDVITFAPPGVFRGFSPPASNFPFVDAATTLWRSLARMTVQNTAGYVRIKSTDATVPPDINIRQYESPEGGPVDLGAMVDAVAWVRRNFLSLPAPYGPVVPTEPPCNAGLTTDGYCKDPEEDKKFIFEQTFGHHPVGTCAIGKKGDKMAVVDSKFRVFGVEGLRVVDASVYPVSPGGFPVLPTFMVGQKGSEVILADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3K0</accession>
    <name>A0AAE0U3K0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_464193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3K0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="71"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="878" mass="98283" checksum="71DFE1261A28B405" modified="2024-05-29" version="1">MAKPYAIVDNAQGDFKVETLGSLSVPTYQYDKLPSQGDHFRLLELFPGEGGRLDCKIVIDKIYDSEKPCRYTALSYCWQNPQFDNLVIGGKRIAADDPIRSTYQICHSLWCNDKRILISTSLRDALHELLAQSGNQTVRLWVDALCINQDDLAERASQVLLMQQIYHNATEVCMWLGREDEFSSLTFQLLGTLASLDTRRPGQQQELINPQAMQRMGVPVFPSEDWEALTRLLERPYFRRIWILQEMIAASLGSKLYCGGLEPLPWTALTASIIFLDRSKWISQIEAQYLSRSGGLSLMLSAISVGVAWMKGASTPAERLLIRREAITAGRRFDATDPRDKIFALIGIINDFGHRDLFGEDSPEGLGGPQTVTKDGTVHATFKLDERGKSKEDIALEIMQSHHDECIKKLHVALLDVFRGCVRVADIILQPEEDYTTEPFLNEYAAITGKTISGLNYIGQFRKDFRNISLDHQRCADFAWNAFTMFSSGISSYIQLIAEFCETDVFVEICNEPEIIEEVSRFREATAWMVESLEPKPPSQAESSGSNDKAKIKTPLVVGDRATLDRLEYAIKFERQYPDWAWSAAGWTMPMYDKPVEQVYTEFMVKCIRDDGNLDILGDVEDSSSRKIKGLPSWVPDFSIPMHRVPFTKWRTGKAEGFYSASGSSKADPKWDVKDAGVLGLSGYKVDEIVALASKELKDDETEERLQEWTAMIDQFVGTTYPAGSCDKIEGLWRTLIGDRSVDGECPAQTEYGAHFDALQRVADVKEGMDSLSLSSSNTVVAGKETFVRATAEVMSERKLFVTKKGYIGAGPLSSRVGGGVYLLAGGHVPFVLRNESDTNLLAGVPRMSLVGDCYVHGIMHGEALLWKDFGWEDVQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3W4</accession>
    <name>A0AAE0U3W4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_492691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3W4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="72653" checksum="89A1C574E1EAAB8A" modified="2024-05-29" version="1">MAASDNTCSSRHDEFPPRGDIRSMMKREPLPFVAPGTVDTASIAGDGGPTKLAEQVLDAFNSALSADDTKTLEKLFLTGGSSPAYWKDQLALTSHLRTFTGAGVVAASLLETKKLRGVVGGGFELKGETAKFVPVTAELQFIDCRFVFKTSSPAANSKGRMLLLPAKKEGGTAKWKIWILSTWLDSLDVHPEDESLLHGPGRKLDRLDVFETDVLIIGAGNAGVTLAARLKALGVDSVMIERNSRPGDNWGNRYECMHFHLPTAFCDMPYLPYDKESLGSRLLLRHDLAEQVRRYIDTFHLNVIHSATVQSTVYDKSAKRWTVKFQTAAGSIITAVSKHLVQATGIGSQKPYIPAMKDSHLYKGISLHSKTYTNARDLVNSGVKSALVIGSANTAFDVLEDCHAAGLKTTMIVRSETYVVPYDYIQDPHGAGAYTLHGTDICDDNFMTVPTWVEASLGYKISRQFADREPDRYKNLAAAGFPVRDGAHPKAVLAHHLLERAGGHYLDVGGTKLIAERRVGVKAFVEPVGFTAGGKGVKFSDGSVLEADAVIWCTGFADKDVRDTVVEILGGGPEEANEGGKGGKNLVYPMDIKAKMEDTWGVDVEGEVRGMWKRQSRMEDVNYWIAGGHTQQHRWFSKMLALQIKAELEGILPPAYRGTPSPVGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4K3</accession>
    <name>A0AAE0U4K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_466056</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4K3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="350"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="667"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="743"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3390577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="908" mass="101557" checksum="7DA5B211D7C70DFA" modified="2024-05-29" version="1">MLPTKKNKNKRPHEVVDLTGVNDPEISRQSKVPRYPSSSSSQFSPSRPRSSFPNDDGEPEAIDLTQSDSGPAREEYGSLQGKIVGVRYYNGVATIGEMVVCVREPHNQYDANAIRVDNVFGDQIGHIPRGTAAKLAPYLDNNEIEIEATIAGYKNSFDCPVRLTIFGPSDLFRRTQLEGRLKQDKLLTATQIKQTRKNNELRLKELVERRLEEKMQETAEEFRRKRMGLKSGRSSAGFTPSQPSEPSEPEPSLQELMQELSKASQAVNFRPGGDIQTLAMDEDELSQMPKAKQPDALRARLLPYQLQGLAWMTAKESPVLPEVGSTEAVQLWKRDAQGRYNNVATQFTTMNPPSLASGGILADDMGLGKTLQIISLIVTGGEGSTLIVAPVGVMSNWEQQIQRHVFGDQAPNVLIYHGAAKQTTAKSLNDFKVVITSYGTLGSESNGGCLSKMKWCRIVLDEGHTIRNAKTKAAEAACKLEAKSRWVLTGTPIINNIRDLHSLIKFLRVTGGIGQSAVFNMAIARPLALGSQQTEILLQSLMRDICLRRRKDMKFVDLKLPAKTEYIHRISFWPDEKKKYDALLSEAQGVLAEFQARSQNGQKGRFQSVLERLLRLRQTCNHWTLCKERIADLLKLLEEQDIVPLNDKNRAILQQALQLVIESQEECAVCMEAMNNPVITHCKHVYCHPCISKVIEIQQKCPMCRAPLSGDKLLEPAPVQSAKEEEEELDMETKSSKTEALLKILQATMKKEGSKVIIFSQWTSFLTVIQRQLDEAGYTYTRIDGSMNAKQRDAAIRALDDDPNTRILLASLAVCSVGLNLVSADTVILADSWWAPAIEDQAVDRVHRLGQTRPTTVWRLVMENTVEERVLDIQSTKRELVDKAFQEKKNKGKETKETRMADILKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4M7</accession>
    <name>A0AAE0U4M7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_391240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4M7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="182"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="482" mass="52831" checksum="72D9BA062A5B9639" modified="2024-05-29" version="1">MGPGRLDFNGNPLAEPQRSQLSAEATPYQPQDAQNPYPYAQATSVGPTAGQWVVNIPPTPSAAYVPDEEATTRRAKPRSRSRAGSARRGGARQHIEPHHAPERHEWDAPPVIERAIHAASVSMIQGLTVPVVLYRGLRDMYYPPPGRPDIIKAYPVRRRLPIRIFFPSHHDMTSPALLPTLFTLHGGGFTVGGSADDDIWNRTFADAYTVLVIALNYAKAPWASFPHPLLDAEALYHAVLNDESLPVDRMRTALCGFDAGANLALGLAQLPSVRTGSNPPPAAVISVCGILDFSAPASRKGRTRPYKRQLRGPRGWGPGLDWMARMLPSSAWSYIPYGHDVADPLLSPAYAARADLPPHVFVVAAELDCLAHESWRAASVWAGRAIPDTDVPVGRRGPSRWRGCLDDGTGENGTKFGWSETHGSSGGSTSWLLVPDVVHGFDSAGWRNKYLWGDEEARMDAEMKTIAYQRELAEWLWGVVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4S7</accession>
    <name>A0AAE0U4S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_539521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="285" mass="32534" checksum="CA09530158E9D961" modified="2024-05-29" version="1">MRLYLLPISTRRTLLYCQKLNAATVEKPTLGDRIQTKASRTWAAWEQKDGGWQKKIVSYGNYALRRISYEEWGLKSVPPLSQRRRELEGKGTENVEVVYPKGLLAIDKVPKVLETLATERQALHKKRLIWCLIGMPISAPFALIPVVPNIPFFYLVYRAWSHWRALSGGKHIQFLLEKNLLTLTPSSIVDEVYLKENRPLPSSPEPTTDPFADKLGDLSPSPETEFKNQAGETMLLSQASGKKLTQALDIPQLEVELERAIWQVETAVKKRNEELSANRKERKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4X0</accession>
    <name>A0AAE0U4X0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_539170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="134"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="543" mass="57018" checksum="57EC517B1AC0529B" modified="2024-05-29" version="1">MAPILAHGLVSVESESAAAMPSAPTPAVQRTYPGAPAEAAEPIELQRIDSKKPKMTVNTASSSSLNNPNQSAGPSGNNKNTSNISTYAADSTDLESSRPATPLAAYGNNSNGNHDGIEVEAMQSIMDPYMNRWRLAAVSLMNFNGGMTDSAPGALLRFLELHYGIGYAVVSLIFVGNALGFITAAAFIDGTRERLGQARTFALAQLIMAAAYVMIVCTPPFPLVVVAFFLIGFAVSFNLALGNVFCGSLRNGTTALGIMHGAYGAGGTVGPLIATTMVTGAAHAVWSRYYLITLGLTVMNGAIALYTFWGYDKVDDYEQTGGGGDQPLFGGEQQQHAAPHTRRKITPKINLAGMLSSFAQPVVLLGALFLFAYQGAEVSISGWVIEFLKAARDGTDSVGYVTSGFWGGITLGRFLLSAPAQRFGEKLCVYIMVGGAIVFQLLVWFVPNIIGSAVSVAILGLLLGPIYPCSAAVFMRNLDRSEQVGGFGIMSAFGSSGGAAAPLVTGLLASAVGTFVLHPVAIALFVVMLGCWYGLPHRARKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5I2</accession>
    <name>A0AAE0U5I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_467468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14378" checksum="23530F8B115D582B" modified="2024-05-29" version="1" fragment="single">MGATEVTPMSRLLYAMLQQTSPKGINWNDVAKHPILSQEISNGHCARLRYYHFHKKMQNLRLQKPTPARVTKGKKDKVCRFCTCRGKSCNGGTPCLECIKLNSYCCYPQTGGTVDVYIPLRKQKKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6W4</accession>
    <name>A0AAE0U6W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_425007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6W4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="585" mass="65092" checksum="699DEE82A82494C3" modified="2024-05-29" version="1">MATITINNRHSAEGFTLNNEPVENLRPLRVVVVGAGFAGICAAIRIPEKLRNVDLVVYEKNEGLGGVWWLNNYPGVACDIPSHSYQYSFAPNPNWSNLYAPGKEIQQYLQDVAEKFGATRFIKTSHEVQHCAWDDTKKQWKIKVTNLITGESLEDSAHVLVTARGQLNQIKWPEIPGLERFQGKKMHSGEWDLSYDFRNKKIGVIGNGSSAIQIIPKLQRLEGTSLSCFMRSPTWISSAFGDQAMVQLGLDPAISEFSEEQRKQYISDPAFYLKFRKVIEDGGNMIHDSTILGSKMQTEGQAMFHASMAASLASRPDLAKALIPAFAPGCRRLTPGKGFLESLLAPNVETIFADSISSITPTGANLTSGRSIASLDVLICATGFHVSAPPSFPVVGRDGTTTLAQRWDPLPESYLSLTVDGFPNYLMMFGPNSAIGFGSLTKILEAEADYVVSVIRKLQKEDYASIEPKVERVRDFSAYVGAYFKDTVYADDCRSWYRRGERIVSLWPGSTLHALEALRSPRWEDYVYEGAEEMAGNALRWLGNGRSITQTSGDPSWYINPDEVQVPCGKRPEENLRYLARPWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7D8</accession>
    <name>A0AAE0U7D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_457644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7D8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="302" mass="32927" checksum="F18AE363EA368DA0" modified="2024-05-29" version="1">MASPFIILDFDGTITHQDTINFIAQSVVSHHKGNSASINTKGGGAQEAWDHILAAYLADYEHHSSNYRPVSAARTTLEQELAFQESLRSVDQASLDRVVASGLFRGITADDLRRAGEEAVRNGRVTIRKGFEAFIGASRNRWELGVLSVNWSKGWVEGVLGGYGEEALVVVNEIVHPEGGVKGPQQSGGRVIMTARDKLEAMRAMRMDLTGGERRLVIYVGDTTTDLACLLDADLGVVVADEDGAKSGGLLDTLRRIGYEVPHIPECCEQGGSAKRKLLVWARDFDEILHSNILERELAKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U895</accession>
    <name>A0AAE0U895_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_461624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U895"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="17">
        <location>
            <begin position="295"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3394673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="800" mass="89650" checksum="9523868ADB6E4996" modified="2024-05-29" version="1">MIPTIRPRRWVCPSCLLRGPPARQLRPAGQRRWLSFESHNPLSQRNPVPVTHSQGGTKHDDDLLRGIFDSPQVWGQFKENASGGRNAGLFGNRYLTNPDGFLAFADVSLKRARGIVAKVLAASTLDEYRAIVRDLDRLSDILCRVLDMADFVRVTHPVMRYQQMANAAWEMVYLYMNELNTMTGLNDQLGRAMDNPDVTASWSDEEKTVADVLKLDFTKSAVNLPKRHRDRFVSLSSEISTVSSEFVQEMAPEKGMLVRPSSTFVGMDPVEARRLTRGGQIYLPTMGAQAALALRTVRDEDTRKLIYCASRTASSKTVSRLELLMKLRGELASLSGFESYGHLALRDRMMAKSPEAVSQFLQALAANNGPRVEQEMASLLGKKKEYDPDATRLEAWDKDYYAESIRQSMRTVQRTDDPLSAYFSLGTVMQGLSRLFTHLYGVSFKPTETLPGETWHPDVRRLDVFSETDGHVAVLYCDLFYRPDKSPNPAHFTLRCSREISESELVEVMDEQTNDPKVAKLRLGFESPEAAANDGMAFSTRNNMLKQLPTIALICDFPQTTSASNRPALLTFFQLETLFHEMGHAIHSVLARTSFQNVSGTRCATDLAELPSTLMEYFAADPAVLAMFARHHETGKALPYELVAEKLRLSKRFEGSETENQIILAMLDQELHSSEALNPKLDSTQIYHNLQCSYGRAPPDPPGTRWQGFFGHLSGYGSTYYSYLFDRVLARRVWDVVFASGQNGAALEVKNGERLKENLLKWGGSRDAWTCLAELLEDERLADGGEEAMGLVGSWGSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JX97</accession>
    <name>A0AAE0JX97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_540128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000023">
        <property type="protein sequence ID" value="KAK3365416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JX97"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14923" checksum="A0C4146E2EC13802" modified="2024-05-29" version="1">MNLPPITTHRSRQQLSQTNFSSEYTTFFSPTYIKQQPSCSTGSGLPRYNGIDVHTRTCVAQGWLVSTGNLASSCFITAIAVNTYLAVVRNYTPPQWALHFTVVGLWVFDYLLAILGPLMTSNGREAGGFYVRAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K037</accession>
    <name>A0AAE0K037_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_535460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K037"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286618" evidence="1">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="34327" checksum="EAA2DB4E6CB6BCFA" modified="2024-05-29" version="1">MHLLRICLVFLGLVTFPIGYGDLGHEIAARATFSQFNKMSLAHCAERLAADRVHENALRLRVDILRNVVQARDDKSPINVDHSANGENFTTSTSPEDLFAQFKSVGRDGYVLAPESTEGPFYVDGEYNRSDLAEAQVGVLLCCNSTGVYGGIKFKEDPGKIHYSWLRGLQETKADGSVYFSALVPGHYTDRCPHVHVATHINATVLPNGTIFSNAVSHAGQFIFDQPLLDTVFELDPCTLNTNLLVKNVDDAFLVGESQTSDPFFEWAYVNTSSPQAGVLAWIAFGVNLTHVRHLSPAATFPAVSPRETAISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0U1</accession>
    <name>A0AAE0K0U1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_535990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0U1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3367879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="380" mass="42148" checksum="2D0CF2D141E4618A" modified="2024-05-29" version="1">MISSNFRVIIVGGGPVGLMAVHSLSREGIDFVLLESGPSIFLDAGSNPALLPIGLRILGQLNLLDAFKSVSSPLGRIQRPDHTARDLGDVNFVHLKESKPTLLLPPILAPRLTRMHPNKKVSTISTAHSSGVVVHCTDGTSYSDTIITGADGAHSITKNAPSSRPTARSRCASPHKLTFAPATPTRRTATTPPFSSSPSEETSVIGIYERLVYGPTCERAQYGPADEEAFVRRWGHLPISKHLTVRDAYDAREQAGLVNLEEGVVNHWSWEWFVFNDCAIALDPSTDTFYLPQTLPGVKARKLEARSGIWSAFEFFDSKYRHRDSLLLQRNSLRHMLGSKYHPAYSDFLMYIDSRELDLTRDSLREYGRGSFGRVYKAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1F6</accession>
    <name>A0AAE0K1F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1F6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="133" mass="14623" checksum="C70D613B65B5874D" modified="2024-05-29" version="1">MITGPGLIALSATLSIGFPGISRQGAAEIHGVSQVPEATRAAVEQDEEEKDKPLLGDMESHLVNMTAGGDKSIDTIDFEQRSEKRGVGVSGPHSVRERPWKLRLPHFVDRILRSFRDKPLLGGRKAPNWLTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1S3</accession>
    <name>A0AAE0K1S3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_528889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1S3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="326"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3368523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="652" mass="73631" checksum="E646ED1ED557A8AD" modified="2024-05-29" version="1">MASPRPGTSATHHSELSVQDPFQDPSDVSSHAASSSRRTSSDRLSAIVASPPGVVLPPPRVEDEDVIAPAPPHVQHEEVLNEKASNIFTSDSDVERGPTVVVAAAPAAATDPEKDAHPVAAPKSRNPFKRSYQAFRRTYCPIEEPGLVFPSGPTDEEKISYVHTNRIPLYIFGLVSFFTLSAGMWLFAVCAPIFAWYGVFVGFLNMYLIISYFVGVIGKDWDYQLHKDMVEQFPITDDTAPTVDVYLPCCSEPLEILENTYKHVVKLDWPAHKLQVYVLDDSNQAVVRALAESYGFNYIVRDDRPRLRKAGNLRWAFSRTHGDFFAIFDADFCPRPDFLKELVVEHMADDKTAIIQSPQFFRVTDEQTWVEQGAGATQELFYRVVQVNRNKWGASICVGSNAVYRRAALVDVGGTAEIGFSEDVHTGFGAVDRGWKVKYVPLCLATGICPNTPRSFFSQQMRWARGSTTLLTTKHFWVSNLTFMQKVCYLCGLLYYSAVSLGIFISPIPGTLLLVLRPEWFKYYNLAFAIPSILYGALVFRFWAKAKYGFNVQHVMVVQSFAYLTAIKDRLFGIELLWAASGDKKAHKSSHKFRNMRILCAMWTILTVGGAISAVTYRLMNHFPWYHTLPLLILNTYNLYITHYFLFCSWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1Z3</accession>
    <name>A0AAE0K1Z3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_487658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1Z3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="237" mass="26460" checksum="8F3AEEDDE3B5C861" modified="2024-05-29" version="1">MEWRYGNRAGEMFEAGGRTVSLGRPAIAAHRRLAADRRKKTDDLLDEHKPFGVKWYPENASIPIPRPTKHQPFPPDVVQRRYSRDHVPIRPKPDGNPTEPAGLFLFFQTRVQRHSNTLCWGAEGTRAGEGSRRIGKGLGMRFGWTFRSPQSSSLNGPRLDFDRTPKLEGAAPAKCSPSFTQGGPSHYGPMRTRRREFLLLSNGAGEGTTHPPWGIVYCPCLTSINSLTKPIFKTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K290</accession>
    <name>A0AAE0K290_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metalloenzyme, LuxS/M16 peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_69323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K290"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="228"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="414"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="808"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3368105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124856" checksum="5B68393DC31BD5E4" modified="2024-05-29" version="1">MASSGRPAPGTPGIPLREESVLSVELLADHLETPSLDDRTYRVIRLSNRLEALLVHDPTTDKASAAMDVNVGSFSDEDDMPGMAHAVEHLLFMGNKKYPVENAYGQYLSANSGSSNAYTAATSTNYHFEVSAKPTNDEEPSATNPSPLLGALDRFAQFFVQPLFLANTLDRELQAVDSENKKNLQSDQWRFHQLEKSLANPKHPYCHFSTGNLETLKTIPESRGINVRDKFIEFYEKHYSANRMKLCVLGREPLDVLQSWVTEYFSEIPNKDLEPNRWVDELPITKEHLGIQCFAKPVMDSRELNLTFPFLDQDLLFESTPSQYLSHLIGHEGPGSIMAYIKSKGWANGLTAGAWPVCPGSPGLFDCQVRLTEEGLKNYKEVVKVIFQYIGLLRDTEPQQWIFEEQKGMADVDFKFKQKTQSYRFTSKISAVMQRPLPREWLLSGSLLRKFDAKLIKDGLECLRPDNFRMTIVSRDVPGTWEKKEKWYGTEYTCQPIPAEFMEEIKQAIMGPTKNRIPSLHLPHKNQFIPTKLEVEKKDIKDTALAPRIIRNDQLVRTWYKKDDTFWVPKANFIVSCKNPLVYASAANTVKARLFTDLVRDALEEYSYDAELAGLQYTVSLDSRGLFIEVSGYNDKLAVLLEQVLITMRDLEICEDRFSIIKERLTRAYRNWELQAPWTQIGDYISWLITEHDHVVEELEAELPDITAEDVRRFRKELLSQMHMEVYVHGNLYKEDALKLTDMIESTLKPRILPRAQWPIQRSLIFPPGSNYVWKKELKDPANVNHCIEYWLYVGDKADRIVRAQTMLLEQILQEPSFDQLRTKQQLGYIVFSGVRAGPTTYGFRFIIQSEKTAPYLETRIEAFLESMVQHIAEMSDADFESNKRSLIVKRLEKPKYLDQETSRHWNQIHSEYYDFESAQQDAVHIKKLTRADVQEFFKKYMDPSSSHRAKLAVYCEAQAKSDVSTKQITELVKTLGLDSTASAQAATDLQARLSAAGHDETKEIEGLTEYLLHELKVAENKIEAAKEAWKKLHAQRGDANGVVKDAEPPSSNETTPFLIEDVRSFKASLVASAGARPARDLSEYEELDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2L7</accession>
    <name>A0AAE0K2L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_404233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2L7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="437"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3368507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="725" mass="79866" checksum="71EC80D700DEAE82" modified="2024-05-29" version="1">MAQRNGSSSPAANPAPAQPPSKSETATPMLNNEMELGNLPGDAAQNDIMQMARLGDIPGMEKLFENTEYDATYTDEEGITPLHWAAINNQYAMCKFLIEKGAEINKKGGESVATALQWAAQRCHYYTVHLLLQHGADPLITDAQGYNTLHISTFNGNVLLIVLLLHQGIPVDVEDAYGHTGLMWSAYKGFPACVDVFLRWGASVHATDEQGFTALHWALVKGSPGCIQKIIEYGADRFAKTTTGKTPSITAQELNTIGAWHKALNECGYGQDGNAIIPSWPGASYLLKDRRGFTTKFFFLWPFLMVWAFLVIVSGMPVYAGIPIGLVVAYAIQWVGKQVLAYAPSDMRTFERTPWMSGIFAASLFLVVAKWMFTVFPNTAFGDDATWLLNFAFAVFAGLTVWFYIRCMVDDPGFVPKMNGIAEQKAVIDELISTWKFDDANFCVTCMIRTPLRSKHCRRCQRCVAKHDHHCPWVYNCIGINNHRHFFLYLINLAFGVITFDFLTYQYLSSMSRNASDQCNILSAPLCRVINTDAYSLLIAVWASLQLTWVTMLLFVQFVQVTRAMTTYENMFGVGHHSAMALNSAFTSTGAPLDPSQLPPSGAAAQPDGAHGHGHGHGHKHGGFLKQWGKLLGVDAFVETATGRGAATNKAGKRSKKNPYSRGCITNCKDFWCDPAPLFGKRETGAAVLGGQRVNYMEMYESPAMMNMAGGRRTGGYEAVAAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K546</accession>
    <name>A0AAE0K546_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_564500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K546"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18272" checksum="494BAA392BE4DFE9" modified="2024-05-29" version="1">MSNKNTSTLQSYVDSATGAVQSVVGSVFGTAGDQAEGQAKQDKSQAEYDASHATAKLPGGITATASGVSKDSKDRSAGSWAQTAGSAKEFVGGVVGSESLKQSGREQNLAGQEQEARGQVNDFASGVADRVSGTVGGAVAGATGDRVKQAEYQHQHDTGKTQERGVEHDIQKQAEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5Q4</accession>
    <name>A0AAE0K5Q4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_402814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5Q4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="260"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="802" mass="88788" checksum="1970776C8A44429A" modified="2024-05-29" version="1">MTSQRAFKIIIVGGGVAGLTLANMLEKFDIDYVILEAHGEIAPPVGASLGLMPDGLLLLDQIGCYEAVRAKAANYNIETSHIRNSDGKSMSCTKGFMGHIESRHFYPMLFFDRQWLLQVLYGQLQHKKDRVLLHSRVKTVVPLEGAVSVVTTDGRTLTGDVVVGADGIHSVIRHEMRRLMMADEIRPGFVPEEEERIPCYYRCLFGISVGVQNWPDDEQTFTNGRGVSFLAVSGPAKRVYWFCFARLAEKKCGKEIPRYYTKEDEARFMEEHGHRAITESVTFGDIYAKRISSTLTPLHEVVFEKWGFERIVLVGDSAHKPNPISGVGGNAAIETAAEFVNVLLRARDKRRDGLLSGLSTSDVETISQEMQKARIRRVKGLVKTAHAMQALFAYERPFVSSIFHTILLPLLGPGFSLEQLSSRFVGGPRLQHLPVPVRPHAIPFKHELPAKPLGRRFVKYARMVFVLLMAFVLLIPLAKTTAFPNRPESPKPTCPPGGDCLGAVAWVTTSKMAQTAFAGFIMYGVECFRIGHQGTLLRVYPVLVAVMLLLGIDMDNKAVSLFAILSAYQSSLRPSGRPIDPHILKMALSISMNPTFLRLAFVVVHMLPIIACLLWPGGSLWKSWLESVPLGITTALLFLLGWRCLLDHNSEPEATDGPKRFDQYKDGDAPQLRAAYSYFFTMQAGAHIAAVAYFYLYASGQRDLWSSIQSVLEALPPSAWIGMAGHCLYSVWELRRLGFVTTREAAQAALAVILGQALVGSGAVWAATWVWREAAIAKMSTLNRPPLESSRHVGGEIKAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X7</accession>
    <name>A0AAE0K5X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_564291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5X7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="623" mass="66038" checksum="10D2D4B1D6A931C6" modified="2024-05-29" version="1">MFGSLRLNPETNQWDLVDKVNGSTYGELGSHLPRHLACDQCRAGKQRCSRQDTVCDRCKAGSIECTYSPRGSKDSRRSTAGRKNSARRETSSKLGRVKSISSSTGSSTPPQAPGRGGAGLASSSPLPPLSTPEVYKQRSRGGAPKKAHVRRSRDDGTCATMPTAASSPMAMEFTNHHHAQINTSPDNTVSPSDLTLEGTLPGDELIGRLTAEMLEHSTKSAYQISSDDGADFDLADFLETGGLGDHTMMQDCSSSRDESTTPWTEDTPLATAAASPSELPSAFDDNNTVMSPMIDGTSHNGRMDGLPPTYSLSAGFLAISSGLNHTNDNNTSLGMSLTTTANHHSHSGNMGPSTGCQCLQSIVPLLSELDRRIHHHKQQELGNHSISQHHHQTLDSVLAWQREACGRCSALLKCRQGCSADADNMMLLALICDKMITLSQSLANQSNPSAMTESTSSSTSSSTTVKNSNNNSITTNTKNGNNMDSSTLADDPFPSYFYDLVTTRNNTNNDKPASLFVGDYEVDGPGDAARIMHQLLGFQVQKVWDLVKAIQAKTAASHAATSSSTGASGGGGNAGGGLGGGGGGGRHVQLAVLHNVEQQACRLLEALNKSYVVRVLYGSCLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8X6</accession>
    <name>A0AAE0K8X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_550703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="11198" checksum="72E8D28E6778B380" modified="2024-05-29" version="1">MFLSPASPYTAMLVIFLLFSIITVVSALATLASSTAALREAQLDGDGDGSTFTYSSSTDDKLNHRASGTKPSLCPSIEEGEAQAEAMAAAVDPMAEAAAAVTAAEPILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA25</accession>
    <name>A0AAE0KA25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_439952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA25"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042154861" evidence="3">
        <location>
            <begin position="25"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="95"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="921" mass="98890" checksum="91F57852C518EE46" modified="2024-05-29" version="1">MRQNIGALLTAAGTLFLSVRTVAAGPGGESPYGAGRFAPDVQIGSRAWNASYPDFEGNAPPYLNDDDNNAGTMNLFTRDALERRARNFPLRLMPLGASITQGAQSSDDTGYRKLLRTQLRWKGWNVVNMVGSLQTGNNFKDNDHEGHGGWTINRVRTDAWPTAQKLKPNLVLVNVGTNDCDDNDASASGPDMEKLIDDIFLGVPDVTLIVSTLARSRDHGACAAAASQAYRDVVAKSKYAGKRLGLADFYNAHTLAEHISTADGKHPNDAGYRIFAAVWYDAITKIESKIQPAGAANPPIDDGATGGPNTCTKEAGDARGPVQSQAGSGHDDGIYVHSSVSRGALTSARIQKNNDPASVIDGIPSHMFFANIVVKNPNFERKDAMDDWIRVFHNPATNKNTYLYRQNNGGGNFGPETTFNVDLNCDTGPTYAFADFNDDGLDDFFCIRGGSAVSVALNRGGNPPTFQSIGQVVGTHAGFDAPDVRIADIDGDGRADYCLTQPNGDVTCSRNARGAQPDEYFWQGFSTANGVGGLVFDKKQGIPDKSGIVFGDINGDFRSDYMYISDSGSVETFINNRGWNAGIVPNWRDAGQTHGGQAGTSGLRNKIKFGRIYGSGRLDYIYLKEEATYVDVLVWENTGGGGTKLKADGNFYCDMRGTGADDYVWIYEDGHAAEINANIHSPPAWGHSTSISLNVPGPRVGIHLADWTGNGRCDVLVQNKATGALTLYENQFSNNALTFTNRGVVSGSGGWCTEGWGVGIFDRGMRLADIDGDKRADVLCLEKNGRVTGRLNKAGGLENVGQVKFSEGFDRANIRFADVEASGRADLIHLDKYTGAATVFKNNGHVAAGGSSFSWANRGVLYSPIDRGETMHFTNQGGLGRADLLHVLPVTNRAWTYFNECGGNGGDDTNPITDPGLPPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA92</accession>
    <name>A0AAE0KA92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_290440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA92"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="157" mass="18184" checksum="74DB849DD8325ADF" modified="2024-05-29" version="1">MPVAARQRDNVKGDPGISRSAICAPGRPRNRYERQTDSHFLILKSFCFLIIFTFVRFIVFSPLAPFFLFMVEVWFSTTNFQVAGLRFLDICKSSCLSRSRNRNPPHAPHKFIPSPTARSGEPPEDTPHEKKKDHPSFFGAPNYQQHQRWRSEISFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAE0</accession>
    <name>A0AAE0KAE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="18" type="ORF">B0H63DRAFT_401304</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAE0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="7"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3372467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="970" mass="107916" checksum="C51ADBE921202800" modified="2024-05-29" version="1">MADGSTWSSTKVRQTFLEFFESKGHTIVPSSSVVPFDDPTLLQTDMLTNDFSFCNAGMNQFKPIFLGTIGKTDPMAKLKRATDTQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAIEWSWELLTKVYGLDASRLYCSYFEGDPAMGLEPDLEAKQLWMAVGVPEDHIIPGNMKDNFWEMGDQGPCGPCSEIHYDKIGGRNAAALVNQDDPMVVEIWNNVFIQFDRQADKSLKSLPAKHVDTGMGFERLVSALQNTSSNYATDVFTPLFKKIQEVAGARPYTDKYGKDDVDGIDTAYRVVADHLRLLSFAISDGAAPNNIGRGYVVRRVLRRGARYARKYFKVEIGSFFSSLLPALVEQMGEQFPDLKQKQADIVEILDEEEVAFAITLDRGEKQFEKYAAAAIKAGENKLSGAEVWRLYDTFGFSTDLTQLMAEERGLTIDENEVEIAKEKAREASKAVKDAVQTFPKLNVHQIAELENEIKIPRPDAEPKYLKGDTKSKVQLIFTKDGFLKSSKDLSPKAPFGLILDKTNFYAESGGQVADTGRVIIDGTAEFRVLDVQEYAGYVVHNGYLEYGDLSAGDEVICEYDELRRHPIRSNHTGTHILNHSLREVLGDDINQKGSLVDADKLRFDFSYKTGVTLSQIAIIEDLSNRYIQQNLKTYTKDVDLGLAKQIEGVRAVFGETYPDPVRVVSIGVEVDELLENPKNPEWRKVSVEFCGGTHVDQTGIIKDLVIVEESGIAKGIRRIVAYTGEGAKNAQRDAKLFKEKLDRISAMDYGDEKAAAVKAAAVELDRLSISTLTKEELRKTFLGIQKLVVEEQKKRQKAESSTALTAVQKHFEQEENKDRKFYVGHLPISANAKAISDVMTYYKTKDKARSVYVFAGSKDDAVMHGVYVGTDLASKGVTAEEWTTAVSTVIGGKTGGKEPSRQGAGAEPAKLEEAVAKAEEWIAEKLKALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDQ4</accession>
    <name>A0AAE0KDQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_254531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDQ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="38825" checksum="98702E8B25DF7FAD" modified="2024-05-29" version="1">MAPPMQLPTRKLGKNGPQIPAIGFGLMGLSVAYGSVGSDDDRLKVLDRAWELGYTNWDSADMYGDSEDLLGKWFAQHPDRRPDIFLATKFGLRAYVKDDGSRAIAVDSSPEYCRQQCENSLKRLGIDYIDLYYIHRVDSKTPIEKTMGELVKLKQEGKIRHIGISASSSETVRRACAVEHVDAYQVEYSPWALDIEGPESNFLLQTCRELGIAVVAYSPLGRGFMTGQIRSPDDFEPGDLRRLFPRFSPENFPKNLVLVEKFKELAAAKDCKPGQLAMAWLMAQGEDILPIPGTKNIKYLEENLGAIKVTITPEEEKEIRKWISDIGITGVRNPPGMLVEFNDTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDV3</accession>
    <name>A0AAE0KDV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_563010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDV3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3375038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46238" checksum="5718B3150C6C4056" modified="2024-05-29" version="1">MASTIIPARAIIPFLVAMMLLTGVCNTLLTKYQDNECVRDCDNPDPKKRKLFEQPVIQTLQMFIGEMGCWLVVAGMSLYSRYVTKAKSYQAVNTTDDDDNDQTTPDNASIRSHTALNGSASASSKDATTSVLKGWRVLLLSLPAICDILGTTLMNAGLPLVAASIYQMTRGALVLFVGVFSVVFLRRHLHLFQWLSLVGVVTGVAIVGLAGAIQPDKKIVHDPHAATADVGAEALRVIVGVLMIAGAQIFTATQFVLEEWILERSSIEPIRVVGWEGLFGFSVTLLGMIILHLSIGQFNPYGPFDMIEGWRQFWHYKPIFISSILIMISIGGFNFFGLSVTRTVSATSRSTIDTCRTLFIWIVSLGLGWETFKWLQVVGFALLVYFTFLFNGIVQPPLKFLKVREVEELLPEEPIEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KED1</accession>
    <name>A0AAE0KED1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_481885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KED1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="15237" checksum="E02AB1A53D078D6E" modified="2024-05-29" version="1">MTVVALKQVTTGRNGVGAFILQCKKMDFHYCDWAGSSKGMNGFIKSILPKFAAAHPQIEFTVSPRPSKHPVIIGHYINGREKAICVRNLEPLQILKKVELLRDASGEKLRRVTKPVQSINESVRGVWSPYHGNGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEM7</accession>
    <name>A0AAE0KEM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_480517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEM7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3374581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="12954" checksum="C1FA3A14358D5EE1" modified="2024-05-29" version="1">MLYEMIGIARQGSLAEVKEIVLTAGQLILRQGGVIRDVKNWGVFMLPRSISRHQVRHTRGHYFVLRYDASIKTHQSVKSTLDIDPRVIRAAGVKLGDGKLETISRFGPINLRAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEQ2</accession>
    <name>A0AAE0KEQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_276213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEQ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40530" checksum="01932E2005F87C5C" modified="2024-05-29" version="1">MALPTLHALEECSDFAKTVQPFIPQLYALPQKVLDVVMSRDGFSDLYVETNPLISGFAISTVLGAVFLVVSEINKNYSQVDRCWSLLPTLYIAHFDAWARLAGVPSARLDAALFFSTIWSMRLTFNYWRKGGYEVGSEDYRWEIIRKQVPAVVFHVFNWTFISFIQSILLFLLAAPAYILLLASKFEPNLTSADFAYVSIELGLVVIEWFADQQQWDFQNAKSEYKKSGKVSQGYSQADLDRGFITSGLWGYSRHPNFAAEQSIWFFLYQWSCFASKNLYSWSGVGPSFLIMLFQGSTWLTELITAGKYKEYSEYQGLVGMFVPSRFSSYKTPPIKPPRVIRTSELAKNLSKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEQ6</accession>
    <name>A0AAE0KEQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_525926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEQ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042048752" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="32658" checksum="81AB155ECC1F87AF" modified="2024-05-29" version="1">MAFHFWILLITSSYLSHAHAITTAEIKFEDTNEYAVATSIDAGGCAVGCATRASAAFEAGPSHVCDAADPFPCICNNATASSTLRDDIWDRCFNGCGYKLSYLATSILAGYCASNTKARVDPVITATATSTVIPGEIYFEDTNEYAQAMSSNGCAGNYAPAITRSFKLAHECDPVDSSPCLCGNATASSLLFASIAAAGNSGCGEPWAQQAASILPAYCSSNAARLLNASVTITTTTRPGGTAGPVTSRGGSAGNSSGVTETGTPSPLPPTSTGGNDGGKGGLSADGIAGVVVGTLTLVVAIILGVWQVKKGRGRARAEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEV1</accession>
    <name>A0AAE0KEV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_279178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="240" mass="27047" checksum="7B02953142F80854" modified="2024-05-29" version="1">MRPSSLPFLCSRTVSRRFSSSKRNLPVERTMKKLAPPEYSSVFIHPTSTQPTPISWNDEKLVRPSIPPCSSSKQYTATNTGPVESEQTRVCLLPKAFPPSDTHHASPTIHSISATMEKEKIQKSIRKQPTNRIPSGSKKQRRKFPPHRDSVYSLSPLRKRRALFLPANEAIAYPISFFFPLRYRTTYSPSLSPFVPAGPLPGVVRLGVFFQNALKRICNPILSFWAKRSHLREGGGGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFB9</accession>
    <name>A0AAE0KFB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_481330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFB9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3374941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="280" mass="29594" checksum="239435B9C1992B97" modified="2024-05-29" version="1">MLYNTAPDKLFIPQTAVDPLGFGKVAIVTGCASGIGLAVTQVLLAHQFQVCGLDVAEFDYQLLREADHGRFHFHRGDLTAPGVCEEGVRIAAHAFGSRVDVLVNVAGMMDNFHSADGVSDDIWDKVVAINLTAPVKMMRSVLPFMKAKKDGVIVNVASTAGMSGAIAGIAYTSSKHGLIGATKNVAWRFRNDGIRCNAVLPGAVDSGVGKTIAAGRNNELWDSEAFAEIEPVHALQARPSESTGSITAHEVAKTIAFLVSDQARTINGVSLPVDKAWGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KG90</accession>
    <name>A0AAE0KG90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy-related protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_482829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KG90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="39"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="244" mass="27551" checksum="D4B03CF47A06ED0B" modified="2024-05-29" version="1">MLFCPLNCVPLLISSFRFSIHHKNPHFSTSGAMSGWREEYLKGVRDADEQHNNPANRELIDACSELVDRVAALEAEKSALQSASEAAPHGPAIASRGTPPTGTTPDTAITAETPVIARLRLDLAEALRGRGQFQTRLQAAEDELVRLRAKTAAESKLIRELTSERRTLMTKIRDREEELRGKTKMVADAHDEMTVLNMELNMETKRRREKEAENKQLVDRYMRRVAQEADAMNKSNEPLFTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJI6</accession>
    <name>A0AAE0KJI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_451679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJI6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="131"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="624" mass="68078" checksum="81652AF7BBD35E67" modified="2024-05-29" version="1">MTIWELWSGRRAESVDDYAGVLIELEEAHLHSHKHRSGRRTELNEFLVDDDDDDYGDSNHHGGGRGKIGGDDDEVTGMLDMSVAEYSIEGLRKEVRQGAGKGETWTAYEMKSKLINKAIQDIGMGRYNWQLFILCGFGWFADNKRRFLIKSFLNHGSLWIQGVSLTLPSLSAEFGVSEKSVRYTASALFVGLCLGSFFWGFGSDIMGRRIAFNATLLITSVFGIASAWASSWGGVCVLFAGLGFGVGGNLPVDGALFLEFLPDASGSLLTLLSVWWPIGQLVSSLFAWYFISNWPADQGWRYFVMTIGLITLVMFIVRYFIFHLFESPKFLLSQRRQAEAVAVVHGIAFRNNRKTWLTEAILDAVVDDDDSNSMPHPPRLLLSTTNIIKSRLATFSGDHLRPLFKTRKLGLTTAIIWFCWASIGMGYPLFNAFLPQYLSHGGGGGGSIASPTPPPEPVSSSSSLEITASSETYRNCVITSLAGIPGSLFAAYTVDMPSPLLGRRGTLALSTLVSAIFLFLFAEFGSSGPLAQLFFSCVEAFAQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRATGLMAPVIAATMAGDGQTAPIYLAAALIMAAFVSMCLVPIETRGRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJR7</accession>
    <name>A0AAE0KJR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_226231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJR7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="307" mass="34724" checksum="C4369A0F94008F97" modified="2024-05-29" version="1">MSVVYEPRNFIHDGSYPPMDDHHDPTPDVDRFADPTDSVVNELATVATYNAPPQTFVDTSEPRLDLGAPPLSKENSPTATTPQRIKAIPKPDREVTKNADGKYVCSWPNCTEETREFGRKCEWNKHMDKHDRPYKCESQGCDKLPGFTYSGGLLRHEREVHGKHGGPKKSFNCPHVYCKRHTNKGFSRLENLNEHLRRVHTQNGGGPTNGAEGETDDAASDTAIAGQKRKREPEAESQDLESDFREENKRVKMENTELRRQVDMLNHQTVMMMKQISQLQEALAQQEALAQQQRMAPQAPMATTSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJU0</accession>
    <name>A0AAE0KJU0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_231683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJU0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="537" mass="59506" checksum="7CDE8EDC32CC4D87" modified="2024-05-29" version="1">MTITSIISLGSTLALATYLKASGAGLLLSVAASSAVQLVVYLGYLSLVYRWFVSSTKALPHPKDTPFILGNLIPFLSEPWGFPLSRWQADIPSTASGFYRIFLGPFDFLIPKSTQAVTAIMTQPYLFEKPAAVRDGLVESLGTGLVAAEGDVHRRQKKLLTPIFGLSRNRRLVPQMWSKSQVLASTMKGLVEEPGERSKVLQMHPLTMAATLDVIGATTLGVDFDSVRNPDQPILEAYQRVFPSLENQSQTQRFFGATLPAIISPHLLFKLPFKPILEFHKGMAMLRRFCIQQIREKKREIEEAKMDDEEIREKDILSALIASGLQDEEEMLSHILTILAAGHESTAITLAWAILKLAQHQDVQNKLRAEIQEAQARLGFGPERPPTLDEINGLLYLRCFLMEVLRLYPAFPAMMRESARATTVGGLSIPKAKPIMVSPYAVNRSQELWGEDANEFRVERWEASHSGGATSSQAFLTFSSGPRICIGKDFATLSLKVFLTVLVARFKFDEAIPGWNPPIQKGTSLKPQGLKVKVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKQ0</accession>
    <name>A0AAE0KKQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_512027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKQ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="477" mass="52368" checksum="D4F7B8149CC1D21E" modified="2024-05-29" version="1">MQAAEMLLQRIYRVPFAPLRLATSIRQPRIPQFFVATCLYSSSTTKVSDPLRILFCGSDEFSCASLRALHAEHKRNASLIRSIDVVVRPGKRTGRGLKVVHEAPIRKVADELGLAVHERDTFTGWNMPRPNSEPINLIVAVSFGLFVPPRLLTASQYGGLNVHPSFLPDLRGPAPLHHALLAKRTHTGVSLQTLSPLAFDAGTILAQTPLPGIPIPPSCTVTQLRDQLAPLGAEMLVRGLRDGVHAPPHEPVGWMPSSTSPPLKHAPKLTQADKQVLWSRSSAEDIALQSRVLGPVWTRALLHDGREKRLMLEDLSPAPQNTWPAQVISFVRTMQQQQQQQQKPASGVHHSSSSSSTDLSSAKEPPKTITWLEASPPTNSAASSSNNTRHHRKTPYFIDEATILVPMAKGGFLRIGSIKVEGDKSRNAATAIKPFSQEQEPVGSGSYFVDELIGLFLDPRLPDHFSSWLEDIDIDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKS0</accession>
    <name>A0AAE0KKS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKS0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="580" mass="61773" checksum="DE0B2D98345CDD2E" modified="2024-05-29" version="1">MQSAGAGVGASGDQTGDSSMLISRSASTSVPASLPTSTSAVAPAAPPAQAAAAAPVEQQVLLRRGSPDLGSDRPGHVSVANSNNQLSEIPKYSARPKTIRKTAKHPIKSAPPIFLRDAGAVPTHHRPLAPGPPPAPPYLHLPHTVAQSLAQPVVRPVSQTVRPPKGEPAKKRPKLLQMPVANPPNRQPTAAEVLRQNLTVIQRQFENGGEEAAPRHASNSSSPHRLGKMLQKDGKLGVTKGQFGPPRKMASNARYPSHPSSQTPNGSSNRTEQPPMAVKFAQTAAPIPKPSTNGVSATNFRRTPEEPRFHGNEGVKDFWTRTGKNNLSLSPANASGKSSAGGASRAVSSPQDPSLNSTFARSNQPLVLKMPPQPVRPPPQVIPIPVQAHTRQPPPVSASDCLGEVSSFDSLIYGQAGAATPPVPIIRVPSFPRTKKKVEPPEDEPVFLGIDPRIHYPQPHSALWLEEKANEIRARGGRKAAFGKTAERLQQQLSRRKQTETFEDRLPDKIVENPAWLSMVKQLHQDAVNSEPSSRSASAVAIAPASAPVVEKKRGKPGPKPKPRPQLTPVDAVAECQPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLA6</accession>
    <name>A0AAE0KLA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alb1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_479175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="216" mass="23229" checksum="0BBE1DA8E18BF14B" modified="2024-05-29" version="1">MAKGGISKPKKGMAQTMSNFLRFKPPNKSPLLGTSLHSRAARRATSPGIDTDKSLKHVKPPVDTTTDVRPAVLAAHHAAGITKKSKKAVLSFKARRRQEKNMDKAEAVMDRTAKKVERSKGQAKVIFSRRRTWDEINKQALNEIPVPSLKKKAVAVPPSKDPLGDAAVAAIYGPIVDDDEEMEVEEGSADVVPTIEAGPPAASTTPPPADDEDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KM28</accession>
    <name>A0AAE0KM28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_480376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KM28"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="208" mass="22768" checksum="F98E89A1894E15E9" modified="2024-05-29" version="1">MGMAKKWNITPRSMKNARNTAMMTRGMLRIVTRVMTGTQMMRAGTPTPTIAVATTTNAGVTTTMMMMRRRIAMKKMTTTIIISPRRSPSIKNQSGPRRSTGTPSRRSPSMRSPRKRSPSGPRSPSGPRSMSNPSSTNGPSTSITNLTRPRRRSLSNLTSLNGPRNTNSPSLRSTNPTSLNGPRDPLETRRKSQLRHLGSRSKGPGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2F1</accession>
    <name>A0AAE0N2F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_455810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2F1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3367740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="35276" checksum="1F5B86FD50282F97" modified="2024-05-29" version="1">MRWFRASKNRLRDVDAAWIFAITSQHKAAAETVHATGELLFVAPEDARSHADFCRYERLHPTSLQGPSLHRMFNDKVEYQQDYTGLQKLIGDGKMNESAGRIVKKREWKAFLDPLQETCFGQVATMWVNMLGSSSVETGVFMENGFELSMRSPKAVKQFYDDDLKKQEQWHVSAGGRQTSGDELTSSTPTTPVVKPAINQAKSSAPPPEVASKPANAHSPVDGAANGPVNGQAPLSAPETSPEELFAKLKAGLDDIAGVEVNKLADDVDVADIGIDSMISMELVKEIQRPSTTPSTRMNSDDDGYKSAPEPETPPTSTKDGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2H0</accession>
    <name>A0AAE0N2H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_405165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1197" mass="130203" checksum="37941DC606AE6E19" modified="2024-05-29" version="1">MDFETRRAPDPRYSYLSNPHDEHVQTFEPSPISAHSASFENLQANSAKTRHRGSDETLVHQSSQQGDSQPQKQEGIQDKNSRTRKLWTPLFLRRPVLIAFALVFTSLIISIAVLFHFLTQDGHILSADPKLHYLWVYGPTAVFVAISAAWVQVDYRAKQMPPWAAMAEGFQPARHSLLLDYIDPLNIVTLYKSIQNRHWTVTCAVAGTFLLQAAVVLSSGLFVSKQTTIYNTDAQVIVHDTFTGQFSGVIDQKPAANAYGILSSNLTYPQGTYERYAFQAMRPRDYAGRIVLLWGSWSGWPGSSLSGRDTAEQMVVSLPTVSPRQGDITADPGSVISSGDGNPQPTSTDNPTNTTSTTSEATSGSVSKFPKFTPGFAVACKPTYSIRKGNVTLGKSENGANTTSITFVVEEAGFTFGNISSWNMLKQFVLSISTASGITGANLDNMIDLSMSNSHANSEVEKNAGTAGFALSRLFGITTAQIANIYLKQPIQTSVLGTTTNQEKCLVISIVALCAIETFLGILTALALFLCWRSPHICASSDPSSIAGLAAVLARSDPIALKLRNTGHERFKFLERLLRNAKFKTEIAPATGNGDPATFRIATISSSESQSSPLSSSSPPTAYYQPFAVTAWGRLVVTVLLVALILTLELLYQRSAGSNGLVDIDDNNTYVQYAWTYVPTAVMVAVGLLLAALNYSIKLFSPFQDLRKGKAPADTSISENYLRSVAGTVLYRATRKREWSVVAAGLAAVLTPFLPIVASGLLKTEPALTISAGRFTRLDTIDLGLRTKGLNPNSFTNPGDAYANMVLANNLSYPRWTYQDLVFPQLASIPSLSNNTASTTDATSVTVSLPAFRARLNCTAATEEQIHCWNYKRTSLTDYAIDTYHITNDQRFLGTGVFGIVNGPRDLYDMYGTRNASCPSVLMAFGHATNHTVDGLSAFVCKPYVETISASATFRLPSWELDTTSSPPPMADESTVKVYNASHIPFFLAEVPGHNFANPLVGNIADQDLGSFFPLVVHGQDGTPIDELAGPENAGRLERAVEATYGIIMAEVMNFQRRSLDFTTADAELVVVGNLTLNTRDKVWLIQSAVSTRILEGLLGVMTVCVLVTYALLLRGSRRLLPMNPCSIAASASLLAGSEMLKRIPEGSEWLSDEERKEKGVFGGMVFTLGWWGVLDNETGQWTGERRFGADYEVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Z6</accession>
    <name>A0AAE0N2Z6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_74933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="145" mass="16100" checksum="20CC126C7CBF793B" modified="2024-05-29" version="1">MIGTTKIKRRKNKTALHLFTALLLALLVSARPLSFCFLRNLQPPPCPFFLLFFGGLAKHIRYFAPYGQYSSANGNDETGPDRHGTDRSSDQNPRGAAMLGYCSDMTCRSLVVSYFEIAAPCADKRRRIAGLFQTSETPTIPDPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3Y3</accession>
    <name>A0AAE0N3Y3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_565204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1284" mass="142432" checksum="65FCDFE704F52CE7" modified="2024-05-29" version="1">MDLNNSSSTTPAGSHNDWFKAAPHEITKGDKPPTLVNQLRSHFENISLLSGIGNLSSFKDQTFDGFLGDGSFYDVQRKEMQHDGQTRIVAVKRLKPTPSGPSLMSGSSPGLRPMIRDVLIMTAMKGSPFILELIDNGSWPEKGFRSTPYCVVELSVDGTLSKFLDIKELAATNDFQAHVALQYQVHDYERRKSLIIDVAMGLFVLHRTGIFHTDLKPDNILIFSSPDGGYRAKLSDFGSSIMRNKAAPDHHILYGRDSGGTEGYMAPELSKLSSVDIQKLSDSELRKLDMFSFAPVMIEAISSCRATGFPLHGKYTERTGELMSFVRDHVGDSEWDTAILRILDKCLASSTTRCDAISEVLALLGKVDLDPFAESVPSAETLSSNFSLSLSAMMDNISHMLGEEIQGDFDVTSELQETPIAAFDSTLSFMRNFRTGLSDLQPFQELLRQWNDTIPRDSSQYYVVSGLSHVFGCGLISFENCCADLLEAAKRENIPAQIIYRRMHEALFSISSIEETGDSESTCPSGLSPLAIQDINPEIFDNEEMLRNEFPDNFIAQAIRFFERWGWATEVYHKLCEIADLSPVENSAWDIRADNDTIRDEQIQDLVRERTEALKALSQAPAALTDYDLMVAAAILFGDEHSSELRDLCEVLQALGVSLHFRITSLGEDISNIASPLMLACYCGNATAVRILAEVSRGSASNTLKGTNGQIPLHYLFTFRDEDADEICDILSQDVQPEDTDSDIHRPAGGFCALVGTPLDISLKVGSLAATRALWRRVYSGNQPFLLTVSPAPGLGYQNPKFKIPSSMINPGDTPVLDIFAIKCFASMQPTIWEFFLSILDDDTKRNMTSSFRELVFAFGDDPGQSRGLYYFLNAYSFMSLSSLSHMILHGPRYTERLVSHLRNGITFFLDVEHPELMSHLLGPLFTWPEPHTQVAMVEACRDLTTTPELAAYDNETLKGIMFLLNTQAANQGLSCGHLLGFILPRMQPASIFLEALAAAASADDIPAFQRIARGLVKQQMNLVDEGAIQFLCAHFASKGCPRDARLYLDMISAMDVPSSPPWLARRAPRWESAQREHEHSKTGSLLSDAVKHKNLDLILLLVDQDPSRLYPGLRSGALFLLCVNDRFEEVLRGLLEHLGPARSIEILRRRSRFSRLTAIDVAIFYNSTQCLRRIAECLTAGGFSMSDLFPLTSVSDKIWGPMMGSLNDSARGQKVTLGVLSLMASRSPMDILSRQWRLGVGQKAMYTFTIPSVLAMSQFVLEMSRSDPEKYEAVQSLTSAIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N421</accession>
    <name>A0AAE0N421_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_497193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N421"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="317" mass="35093" checksum="BCEFF317C4BEC6DD" modified="2024-05-29" version="1">MAQLGLPSPTSRPASSYSGFNFPSSSSSSDGGDHRDGDDAPLPFPEALARRDFLAPDFDPAAYLSALHTGSSARHQTLEDLRSELRDRSSAISAELLELVNSNYTSFLSLGDELKGGEERVEDVRVALLGFRRAVEEVQGRVRERRVEVAGLNEELQEVKSAAELGRQMLELDERTAELEARLAVGSLPGRHTKKEEEESDDEDEEDWGDIDGDQEDDDTDDDVTFVCSSPSKLAALARDYVLINRLASAIGRGLPYIKKMEDRITRCRNTILLDLSTAIKEARRAGARGQRRVLKFLGIYRNLNAQAEAVRVLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4W3</accession>
    <name>A0AAE0N4W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyruvate kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_528029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4W3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054582">
        <property type="entry name" value="DmmA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22290">
        <property type="entry name" value="DmmA-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="10">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="241"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="468"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="550" mass="61142" checksum="BE56B91E72362C0C" modified="2024-05-29" version="1">MMDLDALFTSDTLLEVRSGKMQKMRGLEIESGIDKSLCNGPVHISSLGIDGDEHDLTFHGGVDKAIHGYCSSHYPDWRQEFPSAADRFRPGGFGENFVTAQMNEKTLCIGDVVAVGDDEHGVLLQVSLPRQPCFKLNHRFVLKNFAPNTYKTSRTGWYYRVLREGTVKAGDMIRLVERKHPKWTIERVQEYLHRNQNDEAMNEELAGIEELGPESRNAFKRRVAAKERKARATAEIDLPNKKWREYRVTEKTRQTHRIVSLILEAVEPLTEPGDAALDEGAHVKIKLGNGLVRAYSIVDGDRNRFQLGIALDDRSRGGSKWLHEMTEVGHVLHVAAITAAVPIASAASHHIFVAAGIGLTAFLALVEAYKRINYSATLHYAVRSADDIPFKERVDKLGDNYVVLYDKAAGQRLDVANIIANMPWNSQLYFCGPKRLMDEAARETRARGIPDSEVHFEAFQADVSGDPFEVVVANKGGKLLKVGGEETLLEVLQKYFDVDSSCSVGNCGTCKIDCKEGRVEHRGTALSEAEKSTSMLACVSRGVGRITVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8I4</accession>
    <name>A0AAE0N8I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_452551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8I4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="120" mass="12676" checksum="8E60E09E57569260" modified="2024-05-29" version="1">MSCMAHHSPLRTSFFCGHCARAGHLTAPSAAGASGAAAGGKVGWAGLRRAWLRVKKKPPVWARGVLRWVVLAGGLSASIVGCLWTTPFWWAAVGVVGTFVALYVICWFLEGCPAGFFTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NB72</accession>
    <name>A0AAE0NB72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_524850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NB72"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="149" mass="17608" checksum="B3A842D787D347A7" modified="2024-05-29" version="1">MRWMPDRWDNTMRNSLYICPALRRLSDLCNALAHPHPDWSLHEYDKMLCVAQKIAVVLDDEPRAAEMRALRDQFRDEAETTWAEIQRLSSYEHKLPPGKEWKPHHERLFVSFIRWDRVTGDPAAKTGIPEDLRAAVARWLSQEEDNSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBS6</accession>
    <name>A0AAE0NBS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_221540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042085754" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52864" checksum="9C26519347353AA4" modified="2024-05-29" version="1">MFRTLLTVVVLPWATAEAAGPVNIIHKDVAIIGGGGSGAYSAVRLREDFGVSVVVIEKDGILGGHVNTWVDPATGRGFDAGVQNYLDLPGAKEFFTRFGVATQPNVRNVLDQYYIDFTTGARLTNYSPPPTSDRTAALRRYLQLAEQYLSIMEPGWWTFPPPKDIPADLLLPFRDFVAKYNLTAGVPQIFFTTGFGVHDLMGSLTMWVMRSFNVDLARTILGINTAFVPSSRKNQDLYDAILRLLGDDVLLNSTVVSSERPSANATTNGPVILTVRSSSTGATTLIVAKKLLFTAPPTPNNLAPFDPDPAELSTFSRFRYSATYVGIVTHPSLPRNASLLNTPLAAQPANWLASIPAAPFIARFESYPDSPYYRAIAVGDETLNSAEARKLIEGAFANVLVATTGKTAEEEAPLEFMLFEPHGLVSAYASREDLVRCQGLIQRLNKLQGRRGMWFTGAAWSVHISTSLWVFTDTLLPRVVASLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC14</accession>
    <name>A0AAE0NC14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_452246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC14"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042066570" evidence="2">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="263" mass="26878" checksum="52E7EBDEBA126143" modified="2024-05-29" version="1">MVNYRFFAFVGLAAALPLNINLGAYSPALVVGDGEISFGGKQDVSALMNALEGAAVNAAAGAATAPAAVAAPAAVATPPAAVEAASVDPTLTQQAQQISTLQGMGKEIAPREGTETDSANVAKEKRDLAGFDRALKYAEVGLTKGPKIQLGTGAEGSGVGIIVDNNPAAAKAEKRDVDETAAPRRRSKVTTMYVRRGVPASLQSNSEEIAARDATTAPTQQQARAVQAPAVSSPDTIDAINLNVDGDAGLTMTFVETVEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG02</accession>
    <name>A0AAE0NG02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_415501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG02"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3380818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="625" mass="69460" checksum="51F4CEB4536C2745" modified="2024-05-29" version="1">MAALAFPQFTLSHHDGENELVDVILKRWADALSGQPTVEVLPPGVDVDTWKVILSKFLEILGEKGVIVGDEHKLNYLDIFNLTENEHEVRGSPCALRPTTVKHIQAILKIANEYKMPVWTVSRGKNLGYGANSGRILGSIIIDLQDMDKVIEVNDKYSYYTVEPGVSFFKLYNTIKEQKKNIWSSTPALGWGSVVGNSLDRGWGYTPNGDHSNQVCGIEAVLADGTIIRTGMGSLNDSKLWPLFRGGYGPTYDSMFSQSNFGIVTKMTLWSSPAPLGFKSCHIAVPKETDLVQMVDIFRELLKHEVIQNHPVIGNILRELGKRGTRASWYDGKGAIPDWRLEELAKELDLSWWDANFGLYGPQEIIDINFRRCQEAFSAIPGAKLRGNSYYPDPAKGETYLDAAAVPYSDSWMQTGVPSMHPIVSIQYRGLDGGHISFSPVLPADGQAALDWYMEAKQICANFGFDFVAGLHLYQRHLAHIIMIYFDRQDQEDKTAANNLFVELVLKARKAGYGEYRAHIDHMDLVADQYDFGASDKGANGVPALMRMNQRIKDELDPNGILSPGKQGIWPKRYRGEDTKARGAEIRAEVKKSSESSPSAAEQITNGVTNGVKEITNGIKTALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGP4</accession>
    <name>A0AAE0NGP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydroquinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_395762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGP4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="104"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="220"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43625" checksum="EFD2315D7AEA964A" modified="2024-05-29" version="1" fragment="single">MSKARGNITPLEPDQSDDWTVYEKTVSEDVGYRVVSVPRIFDTNNPTLAQDYCADDAVTGTKKRVLVIVDSYSDTIVGDVTKYFESYAPALDNIKILPMHVASTGKDSAAVLAVIDAALAVGLSPRRDLVIAVGGGTLMDIVGFAASMYAHQGTAGGGGLPFIRIPTTLVGIIDAGVGVKVGVNQGAHKNVIGRYYAPVACLNDPDAFLLSLPEREVACGLAEAIKMALIKSSRLFDMIEGYQAHGSLEHGLKTGYVHETIRLSIRTMLEDLQPNLHEDNLRRLVDFGHEFGHIVEALARHELPHGECVAIGMGISSSLAHRKGILSQTELDRILDCMLRLGLPISATMHGCCDPEVLWRKICTDGTNHKDGMLWLVVPENIGRGTFLGHISDIDAAMLADVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGW1</accession>
    <name>A0AAE0NGW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_545682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGW1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="28018" checksum="9ACD7EBE0BD32C8B" modified="2024-05-29" version="1">MRHSDRIRFPVKALLISTCFIVLVFHFQRRRDFRNGLSEGVPIKLYSSPEPVPVDVVVASMKHEDTERVHKHLPTHWRTTVYVVDDPTASLTVPENKGREAMAYLTCVSLLVFLSLAETTLFIHASRFAWHNDDPDHDAVASLRNLNIAHIQESGFVNLRCVWTLGCPAKIWPHQDATGTLKENSDDDAIPATRPSQPEKSSRKPSWNSCQAPMCPRWSARRAARSLGTRAMLCVATRATSPSAGLWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHA8</accession>
    <name>A0AAE0NHA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_206083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHA8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041968870" evidence="3">
        <location>
            <begin position="31"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="596" mass="64711" checksum="C7F295ED8BB7F2FD" modified="2024-05-29" version="1">MRERGRAYNSVLAFALPFLTPSLYSSYVAAAPSSPSTGGFLRKLKSRVFEEEGQPYDPNNPLNIWWGPAPPPELGPPASADAVRDPIYLPAQIGGIVGSYALSLVLVAVLLLALSKKRRQRIAAAEFPEQEFTIDAFPAPFEHPTEADYKASVDHFQNLTAANEQQHPRSPPNFSVPLGSPRSPTKSHRSYPLGAGVGSQHSIHTIESPVSTIRAPGIDLSVDPVVVKHDRAMAQQQLEDMYKYVMAQDEARAAGRDYDGPPLPSPSTKSTVPNSPSSARTVRKEKNKPMSLNLAKDEKTQSRGSSILSFLKSPRKNKHAQNISISSPIMTPMSGTFPRQEDQEMNAMAPRHYAPPPMPPMPPSNDLPFRRTNSNHMPTPDISPISTQSIDERIDSAVARQPPRSSQIPWRETREDKDDSSHSRDVSQATSASGDVEPVSAGSEKSTSGLVGLPTSPKPGVNRFPSFDTLPTSPKPGSTFSRANRSLAPVNTNATTAVRAGGALPLRAYEPSISSPTASASTYKQTVFTRAAPGPLSPGMRSPWTGAPVPYTPYQPFSPVIPITPSLVTREDRKRMKRLEPKTPTVEMVKGTDEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHC8</accession>
    <name>A0AAE0NHC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_205877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHC8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041915059" evidence="3">
        <location>
            <begin position="22"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="672" mass="68981" checksum="20B3286AE218B10F" modified="2024-05-29" version="1">MRWITRSALVPVSLLVAVASAADIVYVTELSIYSALAPCAASALYYNVQRQTYDACPTPASDLQGCVCTKNRNLASIASAISSSVSYSCGSQAVDDQASASTVLSAYCNQDRVIAFPTPVTPVDVYVTDVPEYQNLAPCAASALYYAVGHMTYSACPTDATALATCACLKNQNSASINSMIASTAKSSCSGMAADVTSAQAMFAAYCNLNNGTSNFPQPTNPPGDMSYYITDLPAYTSLAPCAAYGVSYAVQGQTYYLCPKGSQELASCACFKDGMTGRILSSVTASVKYSCGSTATDDISSAVAVYNLYCSAAGAKVTAQGVTASVSQTRQTPTGGTGPKSTSKGGGTGSGAGTGGGSNGGGSSGGSGNNNVNGDSDASTNGSGLSDPANKNTGPNIGLVAGGAIGGVVALAAIGILIFFLVKKSQKRKAAAHQVLPDTSTPDNGGYDGKHELASDSIAAPLAGPLPPPSPSPSTLKVGPHRGDNVSPVSAHASVYSPPPNKAELSGAAPPPPMPNELQAQGVYPPTPNSAELYGQQRPAYPPAPNSAELYGQQRPPYSPAPNSAELYGGQQQRPMYPPSPNTAELYAQGGQFPQGQGSPYPPPNRPELMGGYYQPQKPQVQEFPGYNSYQGQQPQQQPVELQPVSWQSGPVPGVHIHEMDTSQNHPGHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI01</accession>
    <name>A0AAE0NI01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_561414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI01"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="258" mass="28658" checksum="65099AC54C836BCD" modified="2024-05-29" version="1">MRQCLEPRDKVYALYALSSDRLAFQPPDYTKPVPQVMQETSATLMNLGWGTALVNSPLSSDRLSNTGYASWVLDFASTSWPLHSAYLAGPLEIAESPRIEADAQSGILCLGEEKIPEQLSEFLQELSAKDSSGMASKKLARVCYRSPTFKNVSNTQLLEHLTESTRTKDITKTRWPLLDTRQMMGMAIVKAGGRLGICPDEVMDDDIETQVDRVSHNSSPHYRMVGIAYFEGLSDDKGVDLDAVVEAARRPLVELEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI92</accession>
    <name>A0AAE0NI92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_397022</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI92"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041785900" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="374"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3381987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="542" mass="57503" checksum="FAA725D32EDEE136" modified="2024-05-29" version="1">MWFQLKSAMLPALLSILFLAPGALCAFGYTSSGGNYIIDAASSNTLVFSVSQSSCDIKSIKYRGTELQYGSQGTHINSGLGTATVSISQITGSSKYIKVTCVTSTLTHYMVVREGDSTIYMATYITAQPSIGELRFIARLLPDKLPSEYPYGDVSNTNAASSAVEGSDVYLVNGQTRSKFFSSTRFIDEDSHCVYGGTDLIHVCIMTPQQESSSGGPFFRDIDSNNAGASTNLYNYMNSGHAQTEAYRTGLHGPYLMTFTRSGVPGLKSVDVSWFGELGVTGYVAASGRGTVSGTATGVQSGLQGVVHWYNSAAQYWAKTSSSGSFTSPLIKPGTYTMVLYQGEFKIASTSVTVSAGRTTNTNIAGSLGAAHKTLFKIGEYDGKPTDFRNADKIERMHPSDSRMSSWGPLIYTVGSSPLSDFPMAVFQSVANNIVTIKFTLSSAPAAATLRIATTLSFAGSRPQATINGWKGAAPGAPSKIDSRGVTRGTYRGYGEIYDVAIPSGKLVAGSNTITISSISGSSGDTFLSPNFIFDCVELYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNK5</accession>
    <name>A0AAE0NNK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_432302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNK5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000080">
        <property type="entry name" value="Siderophore biosynthesis acetylase AceI, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF7">
        <property type="entry name" value="ACYLTRANSFERASE MBTK_IUCB-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3384828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="441" mass="49593" checksum="C4381DEE3B9D5D42" modified="2024-05-29" version="1">MTSPSPSAPRRLAAYVASSEPILKLPHPYQTAYAVAKSQAADTYQLIPRDNNNNAANTTPLREALHNPSLSFTEPQDLKSSDRPHESNNTPWGRARRSPAVAVSWTDARQATVGQLWLIAYAIFTLRPAEESFRLQLSGADASQLAHQLKTVGLAIDHPTSSPQPATTDELLVLRGTFWQGAGSPFGSRPAWVPETQSPDLAAYPLPPPAYTMTNEPNSALTWHPIRRAKPTPGTVLYSRYIPHLRETFSMVALDYTNAEHLNLFHTWQNDPRVSQGWNETGTLDQHREYLRKAHEDPHQITILAAFEGTFFAYFEVYWAKEDRIGAYYSADDFDRGRHSLVGDVRFRGPHRVSAWWSSLMHYLYLDEPRTASVVGEPKYTNSSVLMYDLMHGFGLDKFIDLPHKRSAFVRCSRERFFQLCPLDESDKVMGGTGVGLVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNK7</accession>
    <name>A0AAE0NNK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_542840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3384822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="36886" checksum="BDAB39D7F2F1C675" modified="2024-05-29" version="1">MALPTLTFEQIWANLYNMDAFQQVSDQTWLPPKCDCFKIRQVYRCGCPDLGWDNRGHAVASLHQCLAYWLPSHWKLAIEARGFQHIPESHIHLLHQIQFLPFPCFKHQDKHIIYVTPQEATLRINESKNPKNNPPRAANLNKILREHINEAHSVKRCIAEVEAVDPELRAREAKSTKKRKTATTNYGVSLRDKQNIHDFENAHFHMGLVRRDAMPAALEEREVDQCADDSKGDPPDRPWEYNLNHYRPERRPWDNGGNPFHPNYEESYKGYKRGAYMLDERALDTTFRQAWYNKMRPGHLLESDVLRNGWYCQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNL3</accession>
    <name>A0AAE0NNL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_542857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNL3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="35224" checksum="24659530DBB36C21" modified="2024-05-29" version="1">MNAEDEEEEEEEEEEESRPLVVHWTSVNSSKPPSNVIPRSKMNHMLKIPDLPILRGPENIQKWEGALRQTLSLCNLEHFILRDVQGPSLDSIQTRYGDWMGDRARVARFMNASLMDGAVHRALCAHGWNLDEGNSFVTFKIVKQAIPSTTGTPLSFREFKASLKSGKNSTPSPFRAQTPAGISSFNILIPQQHPNQMMTPETHLQSERDRALAEKNALEQEKMALEKENASLQIALKTAGTENTAEIKKRLLATEKDNIDLRAKNKDLLAANRALEARCQRQRAALQILITDDQPRGVEGTGLDANLWDVIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNV9</accession>
    <name>A0AAE0NNV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_509925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNV9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04712">
        <property type="entry name" value="BAH_DCM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000528">
        <property type="entry name" value="DNA methyltransferase Dim-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057215">
        <property type="entry name" value="DUF7893"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25423">
        <property type="entry name" value="DUF7893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="321"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3384986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1102" mass="123743" checksum="68D3A503401F93B5" modified="2024-05-29" version="1">MASRRIFTTSSLKLDSSTSKSGLRTCTSAIRCYIWLDECLPKSTFHGFKPPLPVVTEAVALKALIEFVKKQDGLAGKDFVEFELERFTFYVNTAYYPFEMRPLQHLATKLAHDTLYLDGVLRIGDVRQYVTRVEVSELPIGNYGMSHPTVAGEIWVRSKLNAKKEIYYRLKKPAPEYVRFYNPFLWVVDLAKHFVDFCSYMIEARQQVSLGSFRELFMQRLLQTHKKSPSFQVWRRAHPGNDFRTSIVANVEFLWKEANGVFENGEATALQVFREIRQFTQYPINKSPSPLHIVSGGESASPTIVTPRSCAVDPSRQAMIRGIAAGDTISTPRDGDSTDTKWARVTSMDANDDSRWFGLVQKVHINERTGARSFDVTWFYRPVETPCCLMKYPWPNELFLSDHCTCEEGRDARVKEEEVLATHPVDWFGNPNGSGGNFFVRQTYIVENRRWITLENSHLRCSHGQERLGFASGDTVLAAISRSDQYTEPYEVIKVFRQGLKRFVRLRRLRRRRQVDPQATRTAPNELVYTDELVVINAEKISMMGKLEAHEGAQRCVPLRGDFPTSLRQGFDPQRGGFEKLKGLDLFCGGGNFGRGLEDGGVVKMCWANDIWDKAIHTYMANAPDPEKTHPFLGSVDDLLQQALEGKFAANVPRPGEVDFISAGSPCPGFSLLTKDKTTLSQIKNQSLVASFAAFVDFYRPKYGVLENVTSIVQARHNRKEDVLSQLFCAVVGMGYQAQLILGDAWSHGTPQSRSRVFLYFAAPGLRLPEAPTRSHSHFPSVKSRGLGELCTQEPFVRRSFEPTPFKYCSAGESIGDLPSIYDAKADCCVAFPDHRVAAGVTNLIRHQIAAIPTHPYGMNFSKAWEGGRGVMTPGERDLFPFHSQRTTPISKGWGRVRPQDPFSTVTTRSAPTDARTGSSLHWHDDRPVTVMEVRRAQGFLDHEVILGNCVEQWRIVGNSVARQMAVALGLQFRKAWLGSLYDASCDEVSIPLEAFVGDLKLPKGVQDWSYDKISDTTASHSPSPSDTDGALGRSEMTPITISSTECATEREKVIESRGRKRLLSLPAHIEVYSKRLAQDEEPTQTALGQTIVRISIGEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP25</accession>
    <name>A0AAE0NP25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450 E-class, group I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_522454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP25"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10903" checksum="8C733C0A2B50DEC3" modified="2024-05-29" version="1">MHDKYGPIVRINPWKLHIRDPEWTDVFKVARRAHKPISYYSMFGSNGNLFTSGTAELHRMRRDAIQTIVSITQIDMHLSEAIFPSPYTFLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPY0</accession>
    <name>A0AAE0NPY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_182203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPY0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="140"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="459"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3385394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="761" mass="85122" checksum="92AFD823675FCC25" modified="2024-05-29" version="1">MSLIPYHPREGREIVLRHDNAIVVRDPSSHRLEIRGLQITECPTCHQPLRSSSPERHFDSPSQHENYVDPDYFLMLRHGRNTPSPHPPSSPIRRLVQPVQPAASDARIQDAEFVSSIPAPQEGSRIRREAYSPNYFNNFFIEERELGRGGKGVVLLVRHEIDGCHLGHFACKRVPVGDDHAWLEKVLVEVSLLAKLSHPNLVSYRHVWLEDVKLNRFGPSVVCAFILQQYCNGGDLLNYIIGDVPKETTKEELKAQMRRRSKGQLEQPHSLFAAQRRLPFEEIYSLFKDITSGLAYLHGANYIHRDLKPSNCLLHREGKQLACLISDFGEVQPSNAARNSTGATGTISYCAPEVLKKDASGKYGNFTAKSDIFSLGMILYFMCFGRLPYRSANTIHEELENIDELRAEISDWQGFQEERRERPDLPAKLYQLLKRLLSVKPTERPSANEVLLAMKSESSLDGVTRGATRSQSPAVGLGGHRIQNLDSPIPPSTPVPGQSRSVSAAPLRAKSLPVLSVDPTKHARVSDEDAGPSSLDHSSPQPTTQNILQKHVPPQPTTPRQRHPSHSQPMRSARSPERSIGIRGTARNGTNTNTSPMPSPAIITTPLLMPPPTTRLERIKHHAELRRYQFMHWLDYHAAPPGSFLRLTLLGVKVFSMSWFCWPYSSNLGLLSSVFALAVLDLWTPGGGETAGLVGQVRGHRDMMRVGVGGGEGATVGASRWLSGWRRTLTLLLLHFLILWVTSRFGLMCAIANHDRWTDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ90</accession>
    <name>A0AAE0NQ90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_186365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="37010" checksum="77E8B2C94DA08455" modified="2024-05-29" version="1">MQGNDCKLIPVSSLRQLPNFLPNFVNGYYDMDALDGCRNYIVDICDSPSGRGAAINTGMGSLHFGTMSPSPSFLVYDGMVHEIWTTYLNTDNTNLQPGDSGSWVFDVEDSSDPAVIGQAIACSRGRAHVSLLKTEFEEIPIASKANRPDQRLEYLIRDALSVEVLSRFKNDIFALSLRDLVQETALHVDGHQAEHGVRNIAELLADCGTEILQLLNIAEKLPNLTMASWPRTVRSSSTKVALFSRLASIYHHYDNGLQREYNEKPLIAPTSGTGEVERMGTESIVIEPDTGNGEETSASAPIPSPNLWRTHVSLRPKDERPSILWLIPVPYIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQA9</accession>
    <name>A0AAE0NQA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_186824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQA9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="171" mass="18526" checksum="1CE2A98B1151F24A" modified="2024-05-29" version="1">MAPTPTLPVTPDLTARQVVTTVTVAASASNGSSNSNTGSSLSGGEIAGIVIGVIVGLLLIWWAVRALSGENDNKKQVVVAPDRNRQGWYDDGEPIPRRHSTSRHSHHRDSSRHHHHHHRRSSSGGGGAVVIEEKYAPRRPSATYVAYPEDRRRSRSTGRSRSRSGAYYTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQH3</accession>
    <name>A0AAE0NQH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_187589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQH3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="632" mass="70508" checksum="910577079372E3BA" modified="2024-05-29" version="1">MAKSNPLIHESLEGDAQFRLLHLEPGTGDADVHFTLHVADLDEYPEYEAISYCWGDPAATSTVYCQGHPIEVTNSLSSGLKRLRRSDGIRILWADAICINQYDIPERNRQVMLMSRIYAQPSKVLVWLGDDTTGLEGLDECLKGAHEVLPEEVFDPHVLATNSRKVFLENSIKRKENKPNFSDHDWTPFNNLLCRPWFDRRWIIQEVSLSGAAVPTLIICGDVELMWNDLASVAYRLAAYSIVPLISGLSVINYYAPYMASFFAEGARPVHMLSAVTMTYLLKQYRLEANLVDAVIATPLFKCSDPRDHLYSLLSLSPRSSGLVADYSLSVEEVCMNFATATISRDKDLRVLSLAPHTAFMPGGMEPKRLDLPSWVPDLTCQGGINPLVSYTIREQLFHAGGRGTEEEEQPVIRVADDGRILHLRGRIVDKIAAKAICSIDIPFPTDEDILPKTGWGARLKMRQRNLFQNCRDVAADGDWAGKGKELEAAFSEAVLCGMTGMRDPLPQDVVDAVPYYVSYVFDYFDPDWKLTDELRDKLLTYGALIETSLMGVSEGRCFCKTESGRMGQAPALARVGDVFCVVLGAEVPYVLRPHPEKEGTYTLLGDAYLRGVMQGEALTDSRYETVDISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRP5</accession>
    <name>A0AAE0NRP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_493283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRP5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="247" mass="26967" checksum="39BEE6A4F776DFDC" modified="2024-05-29" version="1">MSATNEFTATAAQINFDFTMIKYEAPPEYQALNQSLSQRRRENAESGQAHVTVRHLGALFDGISPPTPKLISAYGTRASDIVNDVSARGSLNVSNWMFLEYAGIDATSIWAAATSRKAALPIHLPAYLLARVWDESEATSIWVEIVAERRKELASKFESGVEVPIAQTTAADTSACSWLLTADTVKNLQQKQLLLIVKNISIPFNLENNAYKSIMAAWTSALETMELLISGAPYVVRDGTVLLALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRU2</accession>
    <name>A0AAE0NRU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_137738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="393" mass="41208" checksum="E1984C41DC2ED74B" modified="2024-05-29" version="1">MARLALNSCRIAVRMRAALVANNYNNNHHATARRRLFATEADAPSASAAASSSFNNRVRLVEVGPRDGLQNEKATIPLATKIQLIERLARTGLSRIEAGSFVSPKWVPQMSNSSDILEHILQSGIPSLNPLTLSFLAPNITGLNNASAILAKYPDEYAAGEGSEPLSASSGGASKPGIEIAVFAAATEAFSQKNLNCSVAESLERFAPVIQAAKDGGLRVRAYISVVLGCPFEGPNVDPHRVAEIATNLLEMGADEIALGDTTGMGTAPRTKELLTCLSSAGVLNEDVAMHFHDTYGQALINTAVSLEHGIRTFDSSVGGLGGCPYSPGATGNVATEDMVYFLESLGMDTGVDLDAMADIGAWITKEVGRTHDSTVGKAVLGARSRASSPNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSG6</accession>
    <name>A0AAE0NSG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_447753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSG6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58877" checksum="21B551C39DAAEE8E" modified="2024-05-29" version="1">MTSPVSISEAFLLCKLAFKLGRTFTSGRRSAPAELREVENQLYSLSAALLSLDSTRIAASSQLGNAALASELEGGEQGSTILAKMLENCGETLAHLGKILEQYAAMKKPTEADETSFPKRWSRRLVRDFKNINVVLGVVNNEHIGRVEDTLATVIPLLKEIQEYVAHNQHVTTAAIAAQSQAVAALQSKEAPFELRMMLNGSTTKIICPRAMLDPNWSKSSRQSQPRNPELTGRLFTCGCPRSQESPLPPHATRLSSLAYLIDFEELFIQHLATNRARSWLRQATGTTLAFVTTNHDGRQEALVLRTFLSRHQPLKSFLSQTDEKPALVPKDFAHIVIHYRGEMGHDEDIVKTTVRSAETFKTKTTQMCIDLSLIAMRLPRENKVIVLKLQAGGIHTEEIAMAEADITDYHQSRWSYHYEPEAYENQMSSLESLTCYRQTDTSEKVSSDIANDGSSQATFRSRTWVAQMLESGRTQIKEYPNGFNHLILSDVRTNKLFEGWVRSRPLAALPLIEDNKHRVCRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTT9</accession>
    <name>A0AAE0NTT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_470292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTT9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="15773" checksum="173F17E0DE43E226" modified="2024-05-29" version="1">MNRRMLTREEEEAAGEEIEVRREDQDKINKFSRLHQHELSIEEDLTVKNKEREELDDISSELELADEDDIVPYKVGDAFFHVPLPQAQEMLAISGAKIEKEIEILEDKLSDIREEMGQLKVELYARFGKTINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTU7</accession>
    <name>A0AAE0NTU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_160331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTU7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042192860" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="208" mass="23589" checksum="DA1C2089D6B105B9" modified="2024-05-29" version="1">MRLLGNLLFAGMAGLAGHALAHGDHGSGSQKPIVGENASWMEKHMAEEHHAAGFDAASFFALHDFDANGKWEGLEILRTYGLMDDSNKHVTQERRDDIVREILGLLDADHDGSVSRDEFVDFIDQQGKTLPDVGTGPGHHGDDEYEYEIHHWEKYHDENTKLEDLTHPEDIAHFKKHEEMEAEEERLEDLNKRMIVEENIPAKFRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU34</accession>
    <name>A0AAE0NU34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_392821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU34"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="467" mass="51194" checksum="5728CE0029DA2EF5" modified="2024-05-29" version="1" fragment="single">AWNGPDDPHDPYNWSTFRKVTIGVIFSLGQLVTTMSASMIAASLDDIILDLGISEATAQVVFSTFFLGLAFGPFVIAAVAEMHGRKWIWVGAQSWYILWNALCPVGNSTGVMIVGRFMSGVGAASGTTLTGPVMADLYRKEERGKSIAIASLLPYLGPALGPILGGFVTQWVQWQWTFWIMSLVNLVLTLAGLVMLRESYTPVLLRRKAGAVVAALPKTEQPWNWHLGMGFVARFGVAILRPVMMLVRRPIIQIVSVVVAVDFGIYTLQLSTFATLWIRKYGETASQASLHYISITIGITIATQIGGHIMDWMYKRLRDQEMNGGGRPEFRMPYMLPGVILAVVGLFWYGWAAERVDHWVVVDVGSVVFNLGNFVLNQALMAYQLDEFADHAASANAASKMLSYLFGFMFPVFAPKLFDALGYGWGNSLLGFVWLGLGGPVPVVLWVWGAKLRATGRKDGEHGIGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX21</accession>
    <name>A0AAE0NX21_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_388867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3389221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="27113" checksum="D231D724988A3C98" modified="2024-05-29" version="1">MALPLPPGLTHSEVAFLAEMEMVTVVPRQRLESIDLLSGQTPPLRPPHRAQLPLWLALLLKKQRRANIVPPPWLHPASLADIIHRETKGAGFSAPPPPPARANPHEPGRARRFADDDVTLSPPFQPSCTANAPAGYLPYHWLEVAESLLTHAGDDMAAPVGEVRSLLRDLVEVRAAKMRDSISELQGLERGMMLLTGVGSIELAESRGFVLGVVDGVRKIGASTEATRRDKEEMGDERDDEGSDDDMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX93</accession>
    <name>A0AAE0NX93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_463257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX93"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="55943" checksum="013F030F46A78CF6" modified="2024-05-29" version="1">MTYRFRRWQPSVLPSHNMANKLDLLTLTAVELQRLLTDGSVTSEEVVELYLAQIEKHNHVGLKLNAVISTADRDFLRRRARQLDDERKQGKTRGPLHGVPMLIKDICATVDMPTTCGAHAMLAGKTKKDAPIIGTLNDAGLIILGKTNLTELGSLKGLNIMGGWSAVGGQTQTPYVKGGVADGAPFYSHTCPGGSSSGSAVGVAAGFAPLSIGTEVDGSITHPAARAGLYALKLTPETVDNTGFQPGVSGWSSQGPFARSTSDVATLSAIMQLHDPGYYHPLPTAWDGLRVGFVDPSLWRLGSPAAEDVDGYFEQTDAALLAAAEKIKMLGGKVVMSVPLASWETIASAVPDYDEIADLFAFQIKRRFPEFLALFEGVPQSIEEFIQFNKDHADIVFTERDNNQLGLEISRDDTTTQEVHDRNAKAMRESSAGAINRMLEEYGVDVLFGPGDSLFASVAAAAGFPVGNFPLGFAHFNGRPFGLHGTAVDERKVLAVMSAWEATFPENVRRPPLLVEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX98</accession>
    <name>A0AAE0NX98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent hydrolase/oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_445633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX98"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="406" mass="44375" checksum="17CDD0A09B1444F0" modified="2024-05-29" version="1">MAAAPSTSSVTKVTDNRVPSDAASKPHHVLSSKGNLSKFANPHPSWDDGVLGNPIRALFKILGLKWQGKIPAPDTTPPTVTVRAPTFLPSRYGSTSLRATWLGHACYYVEYPSGLRVLFDPVFEDRCSPMSFMGPKRFTKQPCAIADIPIVDAVVISHSHYDHLSNPSVQEIHKHHPEAHFFVGLGLEKWFRSSGITKVTELDWWEDADFTVTPATTEGTGAAASDKATGPAESITARISCLPAQHTSGRTGLDKDTTLWCSWAVSSGKTPETSKSVWFGGDTGYRNVPETIVGDDYAPEHDHLPRCPQFAQIGALRGPFDLGLIPIGAYAPRFLFSSMHANPFDAVEIFTDTKCARAMGIHWGTWALTFEEVLEPPKLLRQALARKGIAETSVFDVCDIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXX0</accession>
    <name>A0AAE0NXX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_103669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXX0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="230" mass="25072" checksum="79E3857416DE7B69" modified="2024-05-29" version="1">MVRILNWRVDLAKHQESTTSVVYSLLFLLSLYMAVFGLESRAADRRRAHKASASQYAAVGSSPLDLAKRAGRICDTAPDVSGGERKWTAEWLGAQKYLELLPQGGGSGCTHQRAVPTWRDSRFRSSPGPVACERGCARFGGLGGQGEWPCNTKNRDLSQTVSTGSHHPKTRSPRQSILARRGPGVSQCSDACGFMTGTCRIWMRRVCTAVDRGDDSDEARDSGGLSPARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY04</accession>
    <name>A0AAE0NY04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_104553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY04"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3389817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="518" mass="57443" checksum="3F004E760728400A" modified="2024-05-29" version="1">MDAKAADSRQVSLESDDKAHVHAHEGDHFTNPHNLNVATMDPEHRARVEKSLKRKLDTRCSLFVLIYIMNYLDRNNIAAARLKGLQRDLSLNDTQYATCLSILYVGYILMQVPSNILINRISRPSLYISAVMIVWGLISTCTGIVTGFGSMVATRFLLGFVEAAFLPGALLILSKWYTRKELTYRNAILFCGNLISNAFSALIGAGVLSNMDGVLGHAAWRWLFWIEGAITMAVAVSAVFILPDLPTNSRGFTEEELMVARLRMTEDVGEADTDSADQGVFDGFMMVIKDVKVYVLMLTFTAYVVGLSFNAFFPTLTKTLHFDDIPTLLMSAPPWVFACIISLLNAWHSDRTEEKFFHITGPICVGIVGFVISMSTDNVAARYVALFLQASSYAGFICFYSWISSSFPRPPAKRAVALAMVNAFSQLGNIAGSYVWDLKEDGFRKSYGIVTAMFGITIVGCWIFRMMLVSLNKKLERGEETAWATHADVAATTAHNEGRSSVDAAATTKLRSEFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY79</accession>
    <name>A0AAE0NY79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042234112" evidence="1">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="23075" checksum="CD1DC1573CB47439" modified="2024-05-29" version="1">MLMHKTTSPTAAPCFLRLFLIFWFTAQSDFHDGGIYTKLAEILSPSSTDDEKESFSDSETTEFLLSQKPRRSAWLRLQTPALYLSNLMLLQVVFILSLQNFQLSQDKSRDPSSTVVSPANGVMEYQEKIFKGGFSTTGTLDLDNNFFRHFTYYIDAIYQPIIYYTDVSPISFYISLLLSVEEARRVAEESGFDYSSVEDDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYD9</accession>
    <name>A0AAE0NYD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_507419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYD9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="191" mass="22144" checksum="5499CDA6EF0338CC" modified="2024-05-29" version="1">MAVKMDVSVLVAEMQDTLSTIHNTIASLDTAEHDARLDELEQKRDNAIQALLAGFTAESDHLSQKRKAERDEIADRRRKEDEERERRRKLEDEELATRNQQQDDERDEKLKYDTKDVEDETDGLMNQVEEEAQRMLEEGRERLTALEEKRRELNRLIDEQLQVALPPALTRARRGGIRTGRFSQAVATESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYZ0</accession>
    <name>A0AAE0NYZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_519221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="185" mass="19315" checksum="8D17CAE376CB6EFD" modified="2024-05-29" version="1">MPALPQPQPQLDSSSPNNNPFGGSSPGASSGSNTDNPFQLPNINSPTGTNGNNGPSFTNPPITIQPPQQFNNAVQAISTGAIIGIVLSTVAFIIFVTVIIILVQRWRGKRRGTRGGINGVEVKSAGYPTFPAAPGAAGSTVGLVPYETAHFPSHHRSTTNHENYHRLDDGGVDHTGIAGVTSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZU9</accession>
    <name>A0AAE0NZU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_539285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZU9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70041" checksum="58A497C7C9DB3C4B" modified="2024-05-29" version="1">MTGSTTPPPPTVVLTGASLYSREHLKIQITTDKASILTASPSKLCPHYHYYLSGAAVLLELLLYLTPQQSQYTHLSAVIMASSTPSSSWGSEERGEAGEPGKAENNVIIVGIDFGTTYSGVAYTWSNKEKAPTAISYGARGEVKWGYAIPREKDQVKWFKLLLLDDNDLPAEARSSEKIKESREYLKKNHCNQCIVETVGRSLGQDERAASFAEMLAARTAGDTELSFISEPEAAALATLSEMDGRHDVKAGDRFVVVDCGGGTADLISYDAVSTNPMVVKECVKRSRWSCRCCLCDECFADLLRRKFTTSKWRKMTPETRAKLLHDEWEHGIKPQFDGRDGLSWQFNMPFECISGNDFRSMTSLPKVTLTSEEVKEAFDPIVNRIVDTVQAQVDSVSAKVGKDPKHIILIGGFGRSKYLYKTLKNLIGARVEVLQSRGAGPWTPICRGAVIQACAKRGISKFDVEVQSMVSRASYGVTMRETWDATKHEEKDKVWCEDEQVWNAVNQMQWFLKEGDEIAAKSQLKFPFYRLYDTESKTVEGKFYQSSASPPPDTYNHTVHKLCEVTWSKLPEMSTIPTWTNSLGKVFYKLKYKIGMECSGASVHIAIYYQGHRQGSKNVTVDYGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0S4</accession>
    <name>A0AAE0P0S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_133861</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="519"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="700"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3391243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131504" checksum="992C1CAC60315A45" modified="2024-05-29" version="1">MDDLESLELLSLVSKVTSELQNHLGISEKTLAEFLIAQRVECASLSEFKEKLAKVGADFPPSLVESIDRLVFALHPKFKGQQNGDHREHDEEPHHGRSAEEKTKVFKGLSIPDKETDAIDDTLALLESLEPKRQDRDRPARKRSRTPGDRRDDSRRKRKDRYRSRSRSRSASPPRGRGKNGRYNNDDDMFKRPPLPEMDDNPILFKVYDGHVTGVKDFGAFVNLHGVRGKVDGLVHISAFGMRVENPSDVVSKGQNVKVKVIKIEGTKVGLSMKDVDQETGMDLAPQLRLGSGANMEALGGGRHGDAPISSNNGNLNGSFQAMAVARQQQKKRMTSPERWEIRQMIAAGIAKASDYPDLEDEYQATLKGEGQMDLEEDVDIEVRDEEPPFLAGQTKQSLELSPIRVIKAPDGSLNRAAMAGTNLSKERKELRQQASDEKEGETKADLSAQWNDPMANPDKVLFNSLKKTHDKHSNPDAAVPEWKRTIAPKDQSLGKRTSMTIKEQRESLPVYVFREQLIKAIRENQILIVVGETGSGKTTQLTQYLAEAGFTNDGIIGCTQPRRVAAVSVAKRVSEEVGCQLGQEVGYTIRFEDCTSPATKIKYMTDGMLQREILIDPDLKRYSVIMLDEAHERTIATDVLFALLKKTLKHRPDMKVIVTSATLDADKFSEYFNSCPIFTIPGRTFPVEILYSREPESDYLDAALTTVMQIHLTEPPGDILLFLTGQEEIDTSCEILYERMKALGPNVPELLILPVYSALPSEMQSKIFDPAPPGSRKVVIATNIAETSITIDHIYYVVDPGFVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTEAAFQSEMLPTSIPEIQRQNLSTTILMLKAMGINDLLRFDFMDPPPVNTMLTALEELYALAALDDEGLLTRLGRKMADFPMEPSLAKVLIASVEKGCSDEMLSIVAMLNIPTIFYRPKEKQTQADQKKAKFHDPHGDHLTLLNVYNGWKQNGYSNPWCFENFIQARSMRRAKDVRDQIVKIMERHRHRVISCGRQTEKVRQALCSGFFRNAARKDPQEGYKTLIEGTPVYLHPSSALFGKQAEWVVYHDLVLTTREYMHNTTSIEPKWLVEAAPTFFKVAPTDKLSKRKAAERIQPLYNKFAGEDDWRLSSQKRAGRSGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P109</accession>
    <name>A0AAE0P109_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_389501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P109"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3391280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="330" mass="35646" checksum="573EA69FB6D71039" modified="2024-05-29" version="1">MSAEMANEIKLISGRSHPDLSDKIAKRLGIEVARTISLNYSNQETSFTVGESVRDEDVFVMQSTATGDVNEGLMELLIIISACRTASARRITAVIPNFPYARQDKKDKSRAPISARLVANMLQTAGANHIVTVDLHASQVRSHLRGRDGFFNIPVDNLYAEPSFLRYIRENFDPEDCVIVSPDAGGAKRATSIADHLNTAFALIHKERPRPNVVGRMVLVGSVADKVAILVDDMADTCGTLVKAAAVLKENGAKSVLALVTHGILSGKAIETLNGSVLSALVVTNTVPLGDKVERCPKIRVIDISPTIAEAIRRTHNGESVSYLFTHAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4C0</accession>
    <name>A0AAE0P4C0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_9398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4C0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="125" mass="13595" checksum="2815BEAF2CAEDA89" modified="2024-05-29" version="1">MRRIVVFAFLPFGDDLFARMIIHQSGTRPQSMFECTGVGTCACARVCAGNNSWPAWFAGATREASHKRATCTTYHASFAVATGTPTGRAGGQPRGADDHKLSDVAGLVVWLSPPEDEEKNSWYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4D5</accession>
    <name>A0AAE0P4D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_443314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4D5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="128" mass="13648" checksum="1A34EE00650EE1BA" modified="2024-05-29" version="1">MASMIARRAFTTTARRLATGEQALKSETKKNPEIAILGGVMVCALVGAGFYFGRSPTSATSENSVPLAKESMPWESGSTEGKYQYHPGGDKSAAPKDAPSAVNVVVVPDVNLPKSLHDKYNKWGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4X9</accession>
    <name>A0AAE0P4X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_458123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4X9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="473" mass="53109" checksum="696FDB255DEEC716" modified="2024-05-29" version="1">MSSRDVVIAVMGATGSGKSTFVSTLVEEEVGIGHGLRSTTRIPMVFSMNRPEEEEKISLIDTPGFNDTALADTEVLQDIAFMLTRTYQLGIRLAGIIYLHRITDNRVGGSGKRMMRLIRDICGDDAYPRVVLATTMWQDLHGSELDGFSSYDRAVQHEVELRRTEDFWGAMCRGGSRVMRWDGTRQSAMAMVDHLKTLRARKGGQGVVLQIQREMVDMQRELIDTAAGQTVGSKNKELAEKFRAEMREASLKFHDEHERRLDNDQLAVDAVREACERQILEAEKARDALKVDFDTLSRQKIANYEALMGEVNQQAGTVKAARREKELQSAEFYRDEPGFEDLFQSELEYNEARLKKLDQKIAEHRALGTPGLDKLLLERKRVDECYQEFLLQYQGRQVEQRIRDSELASLRGEESSLDKKQLALQGFGILAGIGLVVAGVVTIFPPLVAGGVSLAANSMSSMAHGNRKQIMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P516</accession>
    <name>A0AAE0P516_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_18300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P516"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="447"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="836" mass="95639" checksum="2FE259CD3A35A453" modified="2024-05-29" version="1">MMASRGRRPIRKPIMNKEAGEFEPCWEMLRNSMTDIHNKNASTLSFEQLYRASYKIVVKKKGGQLYENVKTFEEEWFQNHILPQISELITNNLVSVALVQQPGSSAHERRQTAEKFLRGVKSSWEDHNMSMNMIADILMYLDRTYTLETKRPSIFATTIGLFRDNILRNTVGGMAQGLTDTFTIFDLVCAVMLDLINMERDGDTVDRNLLRKITSMLEDLYETDEEFDNQRLYITSFEPRFLVASEAFYRNECEKLVREADTSSWLRHTQRRLAEEQDRCETTLSPLSAEKIADVIDAELIKAKLDEFLKMDGVGLKSMIDNDRVEDLSILYQLITRIDKTKAALKTTLQRRVMELGLAIEKNVKETDFSVPVSGAADGDDDGQDKSKPQSLTAAAQQTAAAIKWVDDVLQLKDKFDRLWEVCFQRDLVLQSAVTRSFSEFINIFPRSSEYVSLFIDDNLKQGSKGRSEAEIETVLDKAIVLLRYLGDRDMFERYYQKHLARRLLHNKSEIDTEKEMVRRMRTEMGNSFTAKFEGMFKDMELSKDLAENYREHIRELGDVGVKKTDLGINVLTSNNWPPEVMGRGGAVQESGARADCIYPPAIKRLQESFFKFYLKNRSGRILTWVGSAGSADIKCVFPKVQGKDSGPLSKERRYELNVPTYGMIVLMLFNDLPEGETLGFEEIQAKTNIPATDLTRTLASLSIAPKARVLLKDPQTKNIKATDRFCFNAGFLSKAIRIKAPTITNTSRVEGDEERKETERKNNQTRAHVVDAAIVRIMKQRKELSHTALTSEVISQLSARFKPDISLIKKRIEDLLTREYLERSDGDSASYRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P596</accession>
    <name>A0AAE0P596_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_458352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P596"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="12327" checksum="7A11B9050E862B7D" modified="2024-05-29" version="1">MAPISVYVCAKLATSDVGRYVPEAELVVVVGTLLPFLAYPFLPQKKDPTEVGNAWEPLLQICSLIQLFFVHGINFFILFIRLISNLECNEYPEFLPNYTISLYGSFTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5F7</accession>
    <name>A0AAE0P5F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_26647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="222" mass="24766" checksum="A31ECDD96ABD55B2" modified="2024-05-29" version="1">MRAPSRLFILPQKPPSPPTNSKICAASRAAARIMNLGVFAFNGVQLGQSGFSGEGRLAVRWGTRTGADNTSPNHEHENVFVRPIQGQRPSQGKRLSRFVDTDWMQRNCRRQASESSNLQICSCGRVESQLPVRSDNAKLSRRQRPLCPGPMQISRIQGARPPIRETRRGAARLEETNLIMRVMNEPETTTQRVPTCTSQGRLPKQAAATTIQHLPLLHWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5P7</accession>
    <name>A0AAE0P5P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041905864" description="UBC core domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6362" checksum="02449E7A88B61900" modified="2024-05-29" version="1">MCRGRVIVLSSLIYCLRLGNSDCTHNPEIANLFKSNRVEFEKMAVEWTQKYAAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P767</accession>
    <name>A0AAE0P767_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_444750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P767"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042068299" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="171" mass="18798" checksum="C9E52E3A521F68B3" modified="2024-05-29" version="1">MRFSILATVAFASSALAFPSLGSLLSRRTDCLTEAEAKEIVDIYVRLIANYQDADCEKYCADDFVDRSDSINTFIFKPLGEPTFATKKIFMEAQGSNPPFPVVVDAIDAVACEAVALRWHATFGAANLPSRGLTIIGTTKKTGIWQIKSLDVEFNSLIWLLNMGGNYTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7G9</accession>
    <name>A0AAE0P7G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_517837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7G9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="462" mass="54100" checksum="38A81A5E49F2033B" modified="2024-05-29" version="1">MSLSRSPSPVPGGGWSSPGLNISTSGRSSPTRGYSASGTPVMWESARLKTGYPSFSTQRNNGFFSRHMRNISSSLPRFSSSLPHAEKEKEKEKEKEQLSRGRWSVRSVPLLGRLRGIMGRMGKKMKIRLLILLMLLLSIIIFYTTPLVYHWRRTSWLGGGQKFVIILAANVGGGVTEWKGAREWAIERDSVRNKKKYVARWGYELEIVDMSMKKRYAHEWRESWEKVDFIRTSLRKYPKAEWIWWLDLNTFIMEPSYSLQDHIFNKLENHVYRDINEYNPLNISHPLTEPHLDAVSQSPVGDGNANSVNLILPQDCSGFNLGSFFVRRSPWTDRLLDVWWDPVAYEQKHMEWEHKEQDALEQLYISQPWIRKHTAFLPQRMINSFPPGACSENGNDTRIHYDQRDRDFLVNMAGCEWGRDCWGEMYNYRELSYYLNRSLWERFKEDLIALIWFKITGRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7P8</accession>
    <name>A0AAE0P7P8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxy-cis,cis-muconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_62044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7P8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40953" checksum="560A4EE8228CDDE2" modified="2024-05-29" version="1">MPFHHLMIGTWTPPGVIYTVQFDDEKLTLELVQKTYIPQDEPISWMTFDHSKKNLYGAAMKKWSSFAVKCPTEIVHEASHPIGGDPLATSSETNTRAIFLLAAKQPPYAVYANPFYKHAGFGNVFSVSATGALDKNMQNYPYQPNTGIHGMVFDPTETYLYSADLTANKLWVHQKASDSGEVELVGSVDAPDPGDHPRWVAMHPTGNYLYALMEAGNRICEYVIDPASHLPVYTHHSFPLIPPGIPDRDPVTGKGLYRADVCALTMSGGHLFASSRANSFDLTGYVAAFRLRSCGSIESQLLLNPTPTSGGHSNAVAPCDWSDEWVAITDDQEGWIEMYRWKDEFLHRVARLRIPDHPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7R1</accession>
    <name>A0AAE0P7R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_517941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="20540" checksum="99E3086E6F2D8FA6" modified="2024-05-29" version="1">MPRTVGRTSFQLSLLWRVYSQVPQSRQRKGGAGRDRATEETVNLGPPHAPKEESIKVFNDIKHELKKSLVHIRHEHNKHEPEYFAAVDHLSDSDLAGFDADDFDEVRVASSAYGIHLFGRVRIPALPEDGPAYIHFRAFTSGPEHDAKLHSIHTEEKDEPDGGKTFRAIFTKNDALEWFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8P2</accession>
    <name>A0AAE0P8P2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_385609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8P2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3395267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="641" mass="72309" checksum="AE5769175E020DF5" modified="2024-05-29" version="1">MGSPPLVTPHSLRDALRSAANGLDASAASSGTTSEEDWDELSAAGSPVAVVATGAKKTTKTTSSSLRRELPVLKIGAGEKESQASGGRGIVLSSDDTAVRDMLQQAKASSSSSLSSWGKADGTARRGKFSDLVFTRTFSAFDRQNHAAANSPFHGFFTLFWMSVFFFVLKIGADNWKQYGSPLGNNEIMEAMFRRDLLVLLISDGVMSGMTGVSWLLQRAIKAGYMDWDRSGWVLQNLWQTAFIGAVVGLTLLRDWPWTHTVFFVMHGLVMVMKQHSYAFYNGYLSSAHKKRLLLLAKLKQLEKVSPIQSPSQTEPPVSAISTSHLAHVPSAYEYKKERRRSTSHERGAVPDTDRIAAAIGSGEPLDEEQVQVFERILKWEVDALSDELRGKSSTAARSYPNNLSLVNHYEFIVLPTLVYELEYPRSDSINWYYAAEKMVACFGVIFVMIMVSQAFILPVVMDAVRMKEAGMPLAARFAHFPGMFLELIFPFMMEYLLTWYLIWETILNFLAELTYFADRSFYDAWWNSVSWDQFARDWNRPVHNFLLRHVYHSSISAMKVDKHTATLITFFLSACVHELVMWCIFKKLRGYLLILQMCQLPLVRLSRTKWLRHRATLGNMIFWLGIFTGPSVLCSLYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8R0</accession>
    <name>A0AAE0P8R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_534034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8R0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3395297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="570" mass="60962" checksum="6A4719593DB79D58" modified="2024-05-29" version="1" fragment="single">QTSICETTPGVKGFSGYVNLPATAGYTYNSSIFFWYFEARKNAATAPVVMYLPGGPGTSFLDGASGFPCTVNADSNSTTLNQWSWNTDVNMLYIDQPVQTGFSFTNKQDGLLDLITQEFTHVTDASKLVANLTSLPATLSSQLQTETTNTTTQVVQSMWRFAQAWFQEFPEYKTSNKEISLWSYSYSGFFGPATLAHFAQQNALIANGTLKPSDPKAKALKLGTLGINNGCIDSLIQIPSYPEFAVNNTFGVQAISPEIYAMAKEALDAPGVGCIDLIKDCRAAGEKLDPLGLGNNEEVNAKCVAANKLCFETVQGAYVLSGKSAFDIALPMPGVFPEEYSAAFYNQRWVQSALGVPVNFTLSSNSIPTNMFYTTGDAWRRTVGDLEYVLAAGLNVALVYGDRDYRCNWVGVEAVSLAMSYPSAPSFRSAGYAPIAVNANYMGGLVRQHGGVSFSRVFDAGHAVAAYQPETVHAIFNRALSGKDVATGLSAADAKYSSQGSNSAFLNRTLPKEVPAPARCYVYAVQVTCTEEQIWALGNGTAMVKDYVVVALTGGQNGQGGGNGSTTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ38</accession>
    <name>A0AAE0TZ38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_169313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3384745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="353" mass="40899" checksum="FD5966719D7E1B4F" modified="2024-05-29" version="1">MSSAQARGGARKISFNVSEQYDIQDVVGEGAYGVVCSAVHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYETFNEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPNTSELALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0J8</accession>
    <name>A0AAE0U0J8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_467731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0J8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="221"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3386406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="66167" checksum="DE3C4C0DFA4B7CA9" modified="2024-05-29" version="1">MAEVICPVCEREVSSLDRINDHLDSHCASYLLENISIHDGPNNSNSHGAGGVRNSPPPIQSQPSQSQPPSSTQKKRSAADFFQTPASKRHATVAAVATIGRGTTPLPTNGNGAGGGIKAAAGVKRSFDEAGLSSPTQPRATTWAAPILEEDEGGAKQDAHPEEVKKTNGVESTAAPGSKRSKTSRAAPLAERMRPHSLDDVFGQDLVGPNGVLRSLIESDRVPSMILWGSSGTGKTTIARCIARRVGSRFIELNATSTGVAECKKFFTEAANELALTGRKTIIFCDEIHRFSKSQQDVFLKPVEAGTITLIGATTENPSFKIQSALLSRCRTFTLQALSQDDIQRILLRALEQELNSEGFQPSPLIDEELLHYLSAFADGDARTALNLLDLAVSLTNKPPPPPDSGEPPLTKDDIKAALTKTLVYDRAGDQHYDTISAFHKAVRGSDADAALYYLARMLQSGEDPLFIARRMVVIASEDIGLADNTLLPLATAAYTATQQIGMPEARIPLAHCAVALCLAPKSTRAYRALNNAFSALQEPGVASLPVPLHLRNAPTRLMRDLGYGAEYKYPPNYKDGKVKQDYLPDALLSRRFLEDRDLGTEIDPDANMVDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1D9</accession>
    <name>A0AAE0U1D9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_469724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1D9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="187"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119012" checksum="53637EB124858124" modified="2024-05-29" version="1">MGDSTSIMEDDMKAGLTPLGHKDLETLMKISEYKIDRRKAEKWAHKDIKFLVYDDTNVQQNGYDSDDEDGMIRYALKSSQISRSTTPSGSLNQSLKPKEPSSSSSVQRTVARDRGGGDISYETTTTGGRGNFSHTTVPYKVPSSCDFCDKVPEFPRGYNVRKFRLVKNQLIPRPDDPPGGPRACCHYVAISYCWPVPEKDKDGKLIPAPPGTYKVRDVDGSMRASRTPDHVLDRAVQFAISCGVSMIWIDQECLPQPKENSSQEHKDEQQLGVQAMDIVYNRASITAGLLSSVEIATREEAMAVSDLLNFEVRGSGEDEDVSWKPTGEMPGQNTMATNLNHAIDLLEAIVADLWYTRAWVAQEALSAGDSLALVIWVRGEATCDFEIGFDGVFRIPLLASFEMFPNPGDNSSILALPVREFRSFLRTVRFFLKAAINNPIGEGTERRLRISSRPGYWDARRRDRAWSVLKAAEALHPVPTRPKSLAERLYVSGGNHYQPRQSVDAVGALTLLRNRGCRDVQDRVAILANMCNFGNRLDTSLLARHCKSLRLAMVALAMLNGDNSLLVPEAYDHGVQQVNKSNLRWLWPLSHSPQSIGFFRLRHGDFLGQPMYMQNRDNPFTPDGPRLGGHLWCVDGTIDFAPIQRAYSKRWRVLQVLHDTVTVRHPGETITQFQARLKATLDGGSLLDEPWPYSGDEFLEYYNFVRDDFSEGDFEAALEHARSDMADTIQEAVAGMVFAILRYLYESVDMDPRSIGLANSIWHCVRVDALRSSDKELPDEVGDWVFNDRDVREDPFLLLQLERSLHHRPGFAQLWFIDRIMRDGFLWVGRYEWHSMTPEEPSVTPTASGSSGSGPLKSSESAPSTDTILGRQMSRRFLSSMAGIAAFQRRDDDPRPYNPRGEARTVSAVMSFMRNTLGAEQRDAVRARDLVSAFDVDGPCLVAVPYNGDWEVLPRPSLRSMSVCWVVEPVVLSSKAPRHELGGISSTSFNTPKRTGEQVPSGNPQSATTSAPDSTKGEDKQPELLESKESTKDDNKPHYRVLDKVRGLWQLMDTPDHDYVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3P1</accession>
    <name>A0AAE0U3P1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_499720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3P1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="339" mass="37691" checksum="96E6FA2ECF761EE7" modified="2024-05-29" version="1">MNNIKTKLLMLSDTHALEGLSVPDVSVDVAIHCGDLTDESKMHEFHTTLALLRRINAPLKLVIAGNHEFTLDTPIFQKKAAQSQAVSRQLFTAASDDDGIVFLDEGIYHLSLQNGARLTVYASPFTPSLEADWGFQFKRGEHHDFAMIDQTVDVAITHGPPKGVLDLTSSKQRGGCEHLFAAVAKACPKMHCFAHIHEGWGAKLVAWRDDQPSENPSHFTDIDNGASSVGDRIGAHCEIVGIWRPSSPLARLSCFMKGGRLPSQCGIESLFSRGLGMKPTNEIWKLWPTKPITRHSSSFIVKYVLPRWQEGVNFRRLTTRSWSVWSVLGKPAWGSWVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U487</accession>
    <name>A0AAE0U487_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_499779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U487"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="199" mass="23090" checksum="CDB7805C365B5911" modified="2024-05-29" version="1">MLMINVGRFRSLNVHTSTKRLFWAQGKMSDFVRDLFQPQTAQALERGKFDALFTTRNLSRIAGFKVKLTTNLADHLRFRDSDKAITIFHHATFLKCQLQNPIYPAGFVAETLQTLALLFPENDANTRKWILKCGIIHRRIENYLFWHHRLVVLKDDFNDAQPTTLWYTLWFAISLAIFLGLVQSIEGGMQVYQSWPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4A2</accession>
    <name>A0AAE0U4A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4A2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="566" mass="64475" checksum="09D93C08B3B84E02" modified="2024-05-29" version="1">MAFIFPNLDATGKMYQKTYPNLPSSSRLGDHVAVKKPSRDNARILTTSVSQHPRTTQTQSSSAKLLQQPHNSPGNQQPEATRDMSVAHINPTGENAQGHPSSTVPSELQPAPPTAAHQPVSDPRATVTRSEDEPDHGFGGLTGQRLMRPRLRVDMVHIETPSTKWWKEGIHHKDVSYLFTFPPASMHEDYIQYQEFWEEEFAAPTKYGFDTAVVDTFVHSFSCESGDYLAPMEKEQETRRLLFQKLLNNKQALKDLESQRMFLSMSLKHHDPAKRADASQKEDLQALDNQIEATEEASKRTWKRIKHLMIQAGKYTAETLKWDFDYAETSADIRKAERKKKEREEERKTLNQMIVRMVRRDDEKEKSRTGRPLNPRTVEDKPQPKENNPGRALNVPPPVWNRQRPLLEDHEPEVLGTPTLKDTIKVPNWFAVLEARGVVKLNASGQQARYDELITTLAVCSQKMQNTEQAPKKPFNKQWHEPNPDWPFQDRREKGGWWMCRTGPDATKAEKACKACYAARREASMKLKVAPPSAAEKYAIITAEIDKAMALTVKHDKNAVKAMFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4C8</accession>
    <name>A0AAE0U4C8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_464886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4C8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="429"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="490" mass="54023" checksum="F5DD8952AE01493A" modified="2024-05-29" version="1">MSKYQYLHAINQVHYVHAVLGQHLVRLGVINELALPVARKAVREALDLGDQDGDQGDEFDKMDEVVQYAMTCSMVFCAACWPMHMWQGFGCGVTGDMTFGHVGGGDCISNELDKAIAALKSRPRSWELMSKPPPIQISRTDPNTDLFPEEARKAATKAMRDFMGELERHGFPQPIYSDAPRIVKWHIPFATWEGSTMYQDCGHDPELLCSYQLDPGRFLYDWVVGGRAELSPGEGVLLVNPHVGYLAQWLQGLDGMPSFRVFTDAELDQNRIHQVGRNLKGSTKKFIEWTDEPDYDPFIMVGLPPPQPVNTTSFLAPPAVAPRAITPSPQPAVQSPYCFPPPPSGPPPQQSTSSYGTSPPGSYYTAPPPPYYYSPSPASPTTSYNASPPTQCYQTSPVPEKSALDIMMQSQPQPQHHRPVPLPPLPPRQTTKFATAAYAFSPATDAELGFEAGERLEILDDSDAEGWWTARAGPGRGSRTGLVPSTFFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4R2</accession>
    <name>A0AAE0U4R2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="13" type="ORF">B0H63DRAFT_557869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000034">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="500"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="540"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="638"/>
            <end position="639"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="679"/>
            <end position="683"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="753" mass="85079" checksum="AFC1B6837FD21682" modified="2024-05-29" version="1">MTDTQDIGTAAKPALQNVRSIAVLYGSESGNAEDMALEIGEIAQRLHFQVTVDEMDGFKLTELSCFSLAIFVTSTTGNGDMPKNTTKFWKSLLRKKLRGDSLRRLKFTTFGLGDSSYQKFNWAARKLRARLLQLGASEIFPTGEADERHDDGLDSVYLPWKERLKAALMDGYPPPDGLEPIPDDVQLPPRYTLQLAPAEDTMGNSDAPSKEARLRAEEEERKFLATRTKSAVRTHIDHPRSVPEQLVVDQDRTKGTFPAFMARESPAWENLTGLRVDSLDADNLLKDYPGKYLLKEEVSVTKKPPPSDLLPIPGTFTARLSKNVRITPGDHWQDVRSLHFDVLDIDRGDFPEFGAGCTLLIYPKNFQDDVQELISLMGWEGVADKLLRWTQTATDSASFIARPKKLYIDEKNSTLRSLFTHNLDITAIPKRSFIKQLVHFTTETMEKERLLELTMPGNEQEYYDYTSRPRRTILELLRDFPGVRIPFQRAIDLFPIIRPREFSLCNGGESLKQGHENVVHFEILVALVEYKTIIRKPRQGLCSRYIKHLHTGSILKLGFKPASNLDIISDDEKAARPVLAIATGTGIAPIRALVDDRLLFRNHGSFTLFFGCRSVAADYYFAHEWEDIQGMRVYPAFSRDPVEPPAKESRNPPPTWPLASPSWNNELATLPGYDPDAGKNYVQHQIGKHADVVGDILRRKPIVVVCGNSGRMPQAVRTALLHVVVVAGLARNHADAEKWFNDTRNLIFWQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U529</accession>
    <name>A0AAE0U529_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_132514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U529"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3391132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="712" mass="80313" checksum="489D9DF1C62D0393" modified="2024-05-29" version="1">MFMAYLPPPAYSSPFRGPQGKVAELRLELNSGGKKDKNFTTKKIALKKIVANMTMSNNDMVALFPDIIGCMAIQSLEIKKMCFLFLVNYARMRSEIAVKAIPVLEHDMEDPNPLVRALALRTMSYIHVREFVEATVPIVKHLLRDSDPYVRKTAAFCVAKLYDHDRHMVEASDLIDRLNSLLRDDNPTVVASALASLMDIWERSDAIKLTIDYNNASKMVAILPDCSEWGQTYILEALMSYVPQESGEALLLAERIAPRLSHSNSAVVLTCIRVILYLMNYIADQKQISTLCRKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLRNDIRVFFCKYNDPIYVKVTKLELIFMLATEKNIDEVLTELREYATEIDVHFVRKAVRAIGKLAIKIEPAARQCINLLLELVATKITYIVQEATVVIRNIFRKYPNQYESIIGTLCENLDSLDEPEAKAAMIWVIGQYASRIENSDALLEDFLYSFAEEPVEVQLALLTATVKLFIQRPTKGQELVPKVLKWATEETDNPDLRDRAYMYWRLLSTDMEVAKRIVMGDKPAITAESERLDPVTLEEMCLNVGTLATVYLKPVQTVFRSARPRRLQESPALQRQEVPNPNGLRSDANKSLSQFGNGGQPAEFDPRTGRPEGGNIVQAVHDADAYFTSQMRDMHIQEQGDSFGGNGNEGSGYVVNQYAPQTVYQPAQGVVNNRDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7A2</accession>
    <name>A0AAE0U7A2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_458687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7A2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042255406" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="186" mass="20016" checksum="05E5C4DAA6DBADEE" modified="2024-05-29" version="1">MKWSALAVSLFAASGLASPMFADLDVYTLRLSSTTKSLNGKYLGVNGTLVGVYKETSVVKFIAVPSSEKPSFVELHTYPIGKVDRALALVGKQGLLDFTDVTEPSSVTVPKGTTCDWTSFSLGEKTLKYGGSKAGGWVAFPTGKDATEWSVKWKDASAITIQNYMPVDVVYETTKKTETTEFGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7C6</accession>
    <name>A0AAE0U7C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_458916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="389" mass="43390" checksum="91F20892E286AC9E" modified="2024-05-29" version="1">MLLKPETRQMFVDTDFEAKACSKLKNDSRDDEFLVSRIIFLTTYGTNIDLAKLIDQHGLADTISMNLGRHVKLLSTGKTKADPMESMALVETLKLLFNVTRFCEGHVSSFVSAVPHLVALLVKNDVQNTRTPLDPPLGPIINALLNLPLDDKDIQASFFPKDEPQSVVMRLIDLLDLALKSYSESELEQTTTPLVCVISIAYEHAPSDVRQSIRTGLLPTEEERQNVLGEGNTLAARLLRNSTNPLAPELRNAISHLFFDISDKDASKFVKNVGYGFASGFLFQNQIPIPEAASEAFNAGSSEGPERPVNPVTGQFLDAESVSDLPEMTDEEKEREAEKLFVLFERLKQTGVMDVQNPVEKAFHEGRFEELPDDYEEEEDDDDDSIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U864</accession>
    <name>A0AAE0U864_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_491874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U864"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003016">
        <property type="entry name" value="DEAH-box helicase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="312"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="487"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="906"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3394568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="956" mass="107587" checksum="5512F1FA60FD38F3" modified="2024-05-29" version="1">MGREQEDGRSTKRQRLDFNPLRSDDRFGDLPSRNQRNGAFNSRASTPRAGSRLAGGATPRQKEFDGPEPGVNDPDAVNALDRDWYGGDDDLGGHTFGDDSHNPFGDESGWAAQEREAAMVEKKISQVSRGLNARQMQKQKDVDAWETNRMLTSGVAQRRDLGYDFEDDQEGTRVHLLVHDLRPPFLDGRTVFTKQLDPVPAVRDAQSDMAVFSKKGSRVVKERRQQRERARQAQAATNLAGTALGNLMGVKEEDTDSALPVAVEDEVSKVQNSNKFSEHMKKNEGASTFSQSKTLREQREFLPAFAVREDLLRVIRDNQVVIVVGETGSGKTTQLTQFLYEDGYGKNVAAMSVAKRVAEEMEVKLGSTVGYAIRFEDCTSKETVIKYMTDGVLLRESLNEPDLDRYSCVIMDEAHERALNTDVLMGLFKKILQRRRDLKLIVTSATMNSKRFSDFYGGAPEFTIPGRTFPVDVLFHQSPIEDYVDQAVQQVLAIHVGKPAGDILVFMTGQEDIEVTCELVRERLDALNDPPKLNLQAKIFDRAAPGVRNLTVDGIMYVVDAGYSKLKVYNPRMGMDTLQITPISQANASQRSGRAGRTGPGQAYRLFTEKAFRDEMTNLSNTVLLLKSLGVRDLLDFDFMDPPPQDTITTSLFDLWALGALDNIGELTELGRKMNAFPMDPSLAKLLITSEEYGCSEEMVTIVSMLSVPNVFYRPKERQEESDAAREKFFVPESDHLTYLHVYSQWKANGYNDRWCTQHFLHSKSLRRAKEVRDQLLDIMKMQQMQMISSGTDWDIIRKCICSGYYHQAAKVKGIGEYINLRTSVTVQLHPTSALYGLGFLPDYVIYHELILTSKEYMSTVTSVDPHWLADLGGVFYSVKEKGYSAREKRITEVEFNKKMEIEAQMAGDKQREEDRLQAEENLKLVKKTGPSSKEKTTVTSGAVVKPVRKRPGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8S8</accession>
    <name>A0AAE0U8S8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8S8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042266160" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10862" checksum="C7F4F40200900F69" modified="2024-05-29" version="1">MGRRAPLLPAANHFVVLLAVQGFCTFRAFVSWTNHCFIQRALRDCPSLCARPPARAAPVWRRASGCRFALQMMNHNLWQTGQPDTVLQVHCLCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K035</accession>
    <name>A0AAE0K035_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_83332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K035"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="67942" checksum="08934C56EE6281DA" modified="2024-05-29" version="1">MDLRSVFWSIWTYTTTSCLSNCYNCVTHVPCFLTHDLLVIGVFAFVWATWTQLSVLLPKKPKDNIEKSNNFEVPLPPHPICETSPQQVTKQYPHEDPDGTIDGCNRLLVVGFSAEDGSPQAALCALSASGWQLRARAGRGCSPPLPSTTACASPGLGQPCSTFLVAAKHGRVPVLVLPLNSAICADYQNGCPGQQLPRGNGGSGPTAASRPAKAQSDGIPRRKRKEAASKRRPPKSGRSGKSLGNNSDDSGDGDDSANDDPADQEYPDGHSQFFACPFYKFNNARYHRCGGKLLRNINHVKQHLERAHALERTLYCPRCWCRFPPRSRAAWESHIRDNPSPRCRVTQYQPDDLRNAEMHLLETDRNASQEERWFQMWDNIFSGYERPSSAYIQYGVNEAAQLLRVELPGLLQQFFAAVSPDVAETFSIHVEQSLLRSYSSTVTRYRRYPAAAHQSLNASLIATGNQYTGSTPGQSQDSPAATSPSNMFLPSSHLQPRASSQYLLGGDPPSTLTALIDGLNPQYPLNIVHFPQTGAEQSQIAQHQLDLSGDFTPNNEGRGTRNLLSAYDDGQGLHNTPNIFLNPTVNPRDISILSPLDEHNDDNSQKIDNSEPSTSATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K124</accession>
    <name>A0AAE0K124_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_84210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K124"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042122068" evidence="1">
        <location>
            <begin position="26"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="2">
        <location>
            <begin position="188"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="487" mass="53609" checksum="D9278A2AE93697B3" modified="2024-05-29" version="1">MVDSILTRLAIGLSLTLVAIPTANADITTTLDAKSNLGAWEGWGTSLAWWAATFGTRDDLADIFFTTKSTSFKGQTLPGLGLNIVRYNAGASSSNTYNGTKMAVSSKMIKSRQIEGYWLDWASSNPSSNSWKWTVDSAQRNMLWKARDRGADLFELFSNSPMWWMCKNHNPAGSDDGSSDNLQSWNYNAHAVYMATIAKYAADNWGFKFQSVNPFNEPTADWWKGPTGTQEGCHFEASTQASVIGELRKELDSRGLSSTIISASDESYYDQAVTTFNKLGSTALSKVARINVHGYQYAKGARDKLHSLASGAGKKLWQSEYGENDATGERLVSNMLLDFKWLKPTAWVYWQLLDGGGWGVIDADNDAKSLGAANQKYFVLAQFTRHVRPGMRILDAGSDYAVAAYDASAKKLVIVAVNWGSAQYLNFDLSKFSTPGVDGAVVKRWSTQIGSGSRYAEASDTKISGKRFWAKFDKNMVQTFEVANIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1T3</accession>
    <name>A0AAE0K1T3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_442648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1T3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="523" mass="58804" checksum="B1DE0942858CDD26" modified="2024-05-29" version="1">MAILGLVYAAGVAALAMLCFVLGRALHNILLHPLRTFPGPRLWSASRLPYAWNLCRGRLHLRIRELHDEFGPVVRIAPDELSFTADAAWHDIYCGGFGNKGFPKHAAYRNVQTFVSLFDADDAEHSRLRQLLGKEFFSLEAARRQERIIQEYASRLITQLRAHAHRPVDMRTWINWLTFDVAAQFTLSEDFGCLDRRTYHPWIAMVLTHFKLSAFLMIARFYPPMSTVMFWLAPRGLLRLRDTFIRLVSEKIDRRIGRELPPSHEGDFVAAAFGKRGKEVLAAGQRPLTRGELEANCILLLLAGSETMTTSLLGATHLLCENPAAMRRLGAEVRAHAADEASITLANTTTNMPYLNAVLRETHRLCPPVANGPARVVNRPGTIIAGYPVPVGTAVGVTQFATNRSAQNFAHPDAFHPERWLTAQQASTIASTLNDPSILSEVPQFQTDIRSVARPFVTGGRDCIGQNLSWVEFRIVLARLVWNFPSMRVCRHKEFPAFGEWTDLKAFELWEKEAYNVWLAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K357</accession>
    <name>A0AAE0K357_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K357"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042045735" evidence="1">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="19478" checksum="675E223ADB90F146" modified="2024-05-29" version="1">MVLLISIVSFGFVGAAAAASRFAPYQTPKLACGSVNLLFTGLPAYHPLVTQQGFDPALIDAAVRADSASLLKAGYNVRVVLMGPEQNISVLANRIPGTNWNGVGVGNGVRSAGLPELIVRFEDILQLYHERVPRAPVLFNYISNSTLFLWAAQRHFPLANNCTNSPGKDLGFEVYCDICAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K549</accession>
    <name>A0AAE0K549_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_527835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K549"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="287" mass="31590" checksum="BF7CFC582AE29CB8" modified="2024-05-29" version="1">MLDTNPTLIQEAAGGPSRTGTTPLVLIHDGGGTIFSYHCLGELHRPLYGIANPHFRSGEPWEGGIPEMARHYVKLIKSVIPRGSKLIIGGWSLGGLLSLEISRALLDESDGAAASFDLLGIVMIDSVCPLALPKDKEGGRILVQHVVEWSPYTRQETRDAVMRSFAEARVMVGSWKMPTWRDSNLNTAHDTTSAAVSPILPRPPPVILLRAKEAVPVVEEGVSRVDVHRHDRLLGWDLYHPNLITQVIDISGHHFNLFSKEDNLIEVTEQIKHACRTVEAIAQHRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5X0</accession>
    <name>A0AAE0K5X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_485941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041776984" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="380"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="533" mass="57115" checksum="03D8A6886EC960AA" modified="2024-05-29" version="1">MRYSQGVLVSSLLLGQAYAALPPIVMKGTKFFFENGTQFFMKGVAYQQDTAAAGATTGNTKFVDPLANEAACKRDVPLLKALKTNTIRTYAIDATADHDACMKLLDDAGIYVISDLSEPTLSINRDDPRWDVSLYQRYTSVVDSLSKYSNVIGFFAGNEVTNNASNTDASAYVKAAVRDTKSYIKSKSTRWLGVGYAANDDPKIRAEIAHYFNCGNQTEAIDYWGYNIYEWCGQNTFTGSGYSKQVDFFKNYSVPVFFAEYGCNDLPNKAESRIWEETTALYSDDMTGVVSGGIVYMYFQEENNYGLVSVSGSSASVLNNYKTLSSVIATVKPSSTSSAAYTPSNTPQACPAVGSDWKVKGGALPPTPDNNLCECMYTSLECVPRSDTKETDYGTIFNYICSNDKKACAGISGNTETGVYGAYAMCNAKQQLGYVLDAYYKNQNSAASACDFDRKAQLASSPSIKSGCTASLASASSANDVAATATNAGSPASASTSSFAAPVTMKNLFSMGDMAVGLYVVVAMGVGAGMVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6S1</accession>
    <name>A0AAE0K6S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_319108</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6S1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3370657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="330" mass="37506" checksum="7D68E811FE9E9D9B" modified="2024-05-29" version="1">MAPGAIYDDPVQHDGAVLESISDAIDTVNLLKAQAAEKKKALLAAEPSPEDSVALAAFDAPSEFNSAKDKSSFRQYEAACDRVKGFYAEQHAKQTVAYNLAARQRFHSSARKRPDMTVWEAMEKLDTLVDESDPDTQLSQIQHLLQSAEAIRRDGKPRWMQLVGLIHDLGKLMLFFDGAQGQWDVVGDTFPIGCKFDERCIYPETFCANPDSKHEIYGSKNGIYEAGCGMDNLIMSWGHDEYLYLVVKDQCCLPREALAMIRYHSFYPWHQEGAYREFMAEGDEELLRAVKAFNPYDLYSKSDGVPSVEKLKPYYLELIDEFFPRKKIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6W1</accession>
    <name>A0AAE0K6W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_487445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="342" mass="36926" checksum="AA3B6955EA023C46" modified="2024-05-29" version="1">MDNSPSYVLVTGATGFIGAHIVDCLLGRGIRVRGTTRSAAKGASMIAARPQHAGRLDFVQISDFSSPDIDLSGAFAGIDINGVVHVASPFTYDTLDNEKELILPAINGVRAMLAAAAASKTVKRVVLTSSFAAVLDANRKAPLYFTYTGVDWNPLTYEEAADLNTSAVIAYRGSKKFAELAAWDFLRNNPEVGFDLVTLCPPMTFGPVVHPVPSANSLNDSNAMLWRIAEGKEPLPVARVPFWIDVRDLAQAHVEALVRPEAGGKRYIPASPERFSYGLAAEIIRDGFEFARGREVDLTGQVIDQSHGVDGETAARELGLRYRTFRETVVDMVGRVAAMSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K705</accession>
    <name>A0AAE0K705_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_487339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K705"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="29196" checksum="2082AEB840167C88" modified="2024-05-29" version="1" fragment="single">MAMVLAATHAQTRAHLPTGRALWRVVFVLGLVAYLALGIAYGVLDFILSADAVSAFKDTWVWPLGDRDFALTMDASMIRTLKTGATGAGLSPNYIASRLWSDPEGNQDGSYFYLRGTQIKLGIATDAIALALAVGLFLQVLEALLPGRRKEDVGRRTSLLVAATIGLVLTTLFNIIIDGYYLLWNWGIISSSSQWASFISEYPTPTDIFTSIVPPNGFLPAYRVAVGGFPVVRAVLEPFGVVLACAAITVLVWAEARDRRRHIVFGDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8P3</accession>
    <name>A0AAE0K8P3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_284017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8P3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042123270" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3371959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7880" checksum="AA73CA45043EA8DB" modified="2024-05-29" version="1">MSRCCIGRCTAGTAVHSLILCVCSFAANSQRSLELCEIKYQGNWASGCSQASNSSSLRPCNRSKRDATGAYLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8U4</accession>
    <name>A0AAE0K8U4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_550705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8U4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="14036" checksum="A1C8AEDDF8DCC000" modified="2024-05-29" version="1">MGSLLRATTDHSIFSVKAHHCLLKSQPCTSYIFITSPKRQKPKVKMTETEDKHTPGLGKSSTSNITTPDQAMKSGRQASASNVGLGANEPLPSAGGKGSSYKGSEYTQTTPDIDADQNEIPPDSAIETSKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8W1</accession>
    <name>A0AAE0K8W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_453624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="50517" checksum="2DD0646BA2B1528A" modified="2024-05-29" version="1">MYIEDFHNTIKNENRLLTVQTLETVIHSAASKPRTVSICLDNIEGMNYIDSHAIARELFGDSREEVVSRLLKSSRGIFLIVTFQLSYLAQLPDLDKVLKELEIIDQVIDEKKMLESPFLDYASKYLEPHLQDMDPTSITPHMRMLFDGMKAVEVLSQKKSEAKRLLAMETNKGVWLKSLGLLPFWPNTNADSKHVDRQDATRQAPLLSHQPEQDNIPGYKSRSVLNGQKVYFLPAETFAREISLSDTNCILSPKGTFRAPGDKVWICQLNSDVNLRLYLPTVPKGLYTVMWLFSYQIKSEYKASSSSRETNKLPQRYNISVGRALDPDIFMARVRDLSQPFVLANLNTFLNLRLTTQITVPLVKTQEMEDPHEVLVDYPPQGDIQHPSGGPLDVNWDDGGGLAFLINLVSPRSLEGELNFHGAHLYRLRSQFASDLRQQVQQSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9G2</accession>
    <name>A0AAE0K9G2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_282335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9G2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3371900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44877" checksum="DC183492390A02B5" modified="2024-05-29" version="1">MRLSDRPANKAKPNTRFLGRIIKETTNHNAALLAKEAAEAQARLDDLTEAEEKKRVRLRPSAVDIRRRQLGDISSILLGGGQKRKRAVAEPDNKPSQGGPLNTKGKDKQLINRDERRRKEGRHFQDKGGAADGSPDQRSGRQHSHRHHHRDDEETSRDEPRRRHRSRSPTHKERRNHDRRSRVSGNEGEDEGSQSRRKSHSRRSEKERFQYDDDDLIDAELSRRKKRGRLAQDDDETSKDDTSKKADLIRPSRSQGAQGRLAKEDGDGYMSDPLDEFIGPAPPSQSSPPVVRPRGRGSARGAAVMDSRFSEDYNPTAEVQPDDTAITANSWDESVEVFRDRQKWKQQGADRLRATGFTDEEVRKWEKGGEKDIDDVRWSKAGEDREWDRGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9L0</accession>
    <name>A0AAE0K9L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_551517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="49002" checksum="F37EC9452FB9C9A8" modified="2024-05-29" version="1">MGSQEPAGTTYHRLTSPHNPPLRVVIVGAGLGGCAAALALHHHGHEVIAVLDKVQAFQRLGDSLGLGENAYKLLARWGCNIKEIQEIGNQAPTMKIRRWHDGKVLAEQPLMDMAGYIGHRGDYHDIFLKWVRERDIPIRMGCEVIAYSDSDQPTLTLASGETITADVIVACDGIKSLARQLVLGARDDPVSSGYACFRAYFEPSPDMVADPARNAFLGGDSVNFWIGPDTHVVQNTLRGGREFNWILTHRDEGDVPESWFQPGDMDEVRLLTADIDPSIREAIRSTDKCLDWKICYRKPLATWVSPDSHQIVLLGDSCHAHLPTSAQGASQACESAGVLGVCLRLAQTRGDIRVATRAYEKLRFPRTRVSQTHGEDLRDRWHNVLKNVDQDIEIDPEMVKIKNRPLYAFDAEQDAIDKWEAVVDTVRNEFVRGKIEPLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA46</accession>
    <name>A0AAE0KA46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Soluble quino protein glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_439987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042156191" evidence="1">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="35"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="44175" checksum="17B74D58ACD08CD5" modified="2024-05-29" version="1">MAFLTTRLLAALAWGMLVLQVAAQCSGVSKTSNQKLASGYTSSVLVTGLRTPRGIAMDTEGALLVSEQQGGTIRRLTLKDQGSTVCVDTNKVLISESTSNHGVAVSADGKTIFVSNLQKVTAYPYDPVAGTVGAGKAIITNMQNNGPHPTRALMTSKFSPDTLLVAIGSAANVDTPTTAQSAGRSMIKMFSIKQISATPVTYNAGGEVLGWGLRNIVGMGEHPINGGVWSVENSMDDIKLGGKDVHNENPAEKANFHGMLNDTANKLKGANYGYPSCVPAWDTGVLGVSTLAVGSLFSPDGVPKASDCTSRQPGRIHFPSHTAPLDIKWTPDGSAAYVSFHGSWDRRPPDGYRVMKVAFGPDGQPTAPLTSRSAAVTIMENPNTGSCPSGCFRPVGLAFDSKKRLFVSSDSTGEIHVIYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAU6</accession>
    <name>A0AAE0KAU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_302890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAU6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="416" mass="45904" checksum="EE318658B7802361" modified="2024-05-29" version="1">MWYLGGLPIVERNHGMVFALFFFTALALAIVSLRIYTRALVVRIVGPDDYVIILVMLGLIGYLTACMYQVKYGLGDAVRLADLVEFLRSLYVTIVLYNANQLLVKLSLILQYKRVFQTASTKRFFLGLLTFFTVYALIAMTLTIFTCWPIPYYWDESIEGGGKCLERDILHYTLAGFNIVIDFAILLIPLPFLRQLHIATRNKLILLGVFTCGFFTCIVSIVRLRSLALNFSGPIDQQPIIGVDIVLWSGLETSVATICASIPALQALLLKLFPSLKSRTGTGSRSTPRRSKPGRVNTPTPMLPLHNFISRKSGGRNIESALDTHFDNAEDPSSGKLAGIKIRRSVELKMVAARYGDNESESELVGNTTMWRSDCYADAEMGTISGADTPGGATTSRTSSNNGGEKGIEVVTVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDA8</accession>
    <name>A0AAE0KDA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_548862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDA8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="214" mass="23318" checksum="3A9B9330C6A98055" modified="2024-05-29" version="1">MTNHGTQNLLCLPPKLSDYVLFFAANYVSHAATLVSVPGETSTETIVAALSALFVPGYGILRALPRLFLHAGLTHNSELRRAARAVSSLKRALHGSMARSNLSSSLDNIQLDDESFVLIQLPPDTPLRSFRSQIDTTAPEPTLSYTYNIPKIIIGLLKAVWGTVTLYKSRGSQIDLYGYAALGLSVAPYVFMSLVNIAIALVTPEYPALYYQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDN7</accession>
    <name>A0AAE0KDN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_496272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3374933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121157" checksum="A2C45C0387EDC484" modified="2024-05-29" version="1">MAGYSRPSSFSDHRKRSSFGDELTLHTHAGKMSQQRPRGPPTPSMSTPAADFDQQLTGSPPPPPTPAASPGPSHARPNWSNAEESEEVYLSELRQHFVKCSSPQRQRLLADLFNLCTSQQLSFVHQFVSPLLKKDPFTSLPDELCLRILSFIDDPKVLARASQVSRRWRDLLSDDMTWKNLCVKHDYQRRLSEVQPSVQLPPIRDLFSLTNKDGAPTSRTFPGALPPTLLGSGPLEVDGGAKIPPVNPRPRLRSYKSHFKQRYLVDAAWRTGGRNISRNITQDGGVVTSLHLTNKYIIVALDNAKIHVFDTEGNAQRTLSGHVMGVWAMVPWDDILVSGGCDRDVRVWDLTTGVCLHTLRGHTSTVRCLKMSDANTAISGSRDTTLRVWDIKTGLCRNVLVGHQASVRCLEIKGDIVVSGSYDTTAKVWSISEGRCIHTLQGHYSQIYAIAFDGNRVATGSLDTSVRIWNAATGECQAVLQGHTSLVGQLQMRGGTLVTGGSDGSVRVWSLERFCPIHRLAAHDNSVTSLQFDDTRVVSGGSDGRVKVWDLKTGHLVRELITQGEAVWRVAFEEEKCVAMALKNSRTVMEVFSFSPPEEVLYERPLSLPQRAIDAPVPERPLSAFSLDYGTSSSVMQDVEMMDAGPSTAPLQRSSSPFFPDGGFQLRTARKPQPPPNRPSTIITMFSRAARLARAVPARAAAPRAPIPSLVVRRSVTTNAASAQVDKSSVPQSDEEPFQVTLSDESFETYELDPPPYTMEVTKKELKQMYYDMVVIRQMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAINKTDDLITAYRCHGYAYMRGATVRSIIGELLGRREGIAYGKGGSMHMFTKGFYGGNGIVGAQVPVGAGLAFAQKYMDTKRATVILYGDGASNQGQVFEAFNMAKLWKLPALFGCENNKYGMGTSAARSSALTDYYKRGQYIPGLKVNGMDVLAVKAAVKYGKEWTEGDNGPMVLEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQHILDWGVAQEDELKGLDKEARSHVNEEVAIAEAMAVPEATPKILFEDIYVPGSEPQFIRGRTLDENFYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDR4</accession>
    <name>A0AAE0KDR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Repetitive proline-rich cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_262644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDR4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042259302" description="Repetitive proline-rich cell wall protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32370" checksum="1EEE01469558E5EF" modified="2024-05-29" version="1">MKVALSLVALAASALGANVGRTYPKETPDKPKDTWQTVTTKVVVTYTTVCPVTETVSKPGSTYYTTYTTTKTTEKVVPTTIVVTKQAPPVTKTANSVVYTTLTELCPVTETKVIEGSTVEVVWTSTSTVVTRVAQTQTVYTTDIETEYETTKVYETVTCPEIVYTTVVEGETVYRTKTSSITLAVTKVQTVTAVVPVTITRKIDVTVPVTKSSQLTLTDYSTVVVSEGNTIYSTEELPPTTIIIPTTSTKTATTVIPTRPVTSTTSTFTAPQNTTVPPIPTAAANKLSPAVALLAGFMGVVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEP6</accession>
    <name>A0AAE0KEP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_275484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEP6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="90" mass="9917" checksum="8902B65889A05B79" modified="2024-05-29" version="1">MLDKLVGLAMLVAASVVFLYYTIWTLLMPFVDSDHPLQNFFPPRVWAIRIPVILVLLGCAVVGSFLSVVMIRSNKKKAAKAKAVASKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEQ7</accession>
    <name>A0AAE0KEQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_481945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEQ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="87" mass="9493" checksum="64598EA2F2A23AE2" modified="2024-05-29" version="1">MQGTLGSGRRKGTREKNQIMSWLQTALVGLFLWLASGSLQASRLVRPVALTPEVLADLGCPAGTYTYSSAIACTLHAYIHGRAWRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEZ8</accession>
    <name>A0AAE0KEZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_482982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEZ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29973" checksum="77030BC6FAA508B6" modified="2024-05-29" version="1">MAEKYPDAEVFGTDIAPIQPTQQVPFNIEFHIENAEEEWIRPANTVDLVHLRNMAGAFGDWKFIYGQAFECIKPGGWIEVLDYDDMYAYQNFLTFYPEDSPVHHLFKGIYEALDKSGRVRGRDHMREELLIEAGFVDIRDTVYDLGIGSRASSSYGKFWLFAVVTGIEPTALRLLTKYLGWDPDYARDLCEQVAQETKKMAEDPVRAESFVIKLRVLSGRKPDVPGAWTAQVLNETAEMVDLSGADDDSTIGSRSNKTLRSEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJW2</accession>
    <name>A0AAE0KJW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJW2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="387" mass="42944" checksum="34A7A1200FBD98FF" modified="2024-05-29" version="1">MEDNQQQQPRGFDALVDELTDAFAQILYNFSVPFSQWPTQETPILNLWTWVDRSREVREAELPERTGNRSPPWTHSAYVLYGRAYLVQASFFVERSPAWPPVPEGLDASTAITVARVRSSLRDKLVIKLVDKSWGMELPDVRGAYREISLAEANAWRRDFPDWFPPLLELVFLPAPANGQQQHGHDVNGNGHVNGNGANNGNGNEPTPIADALPQDIENWAQDEDGDITMGLLYWPDDGPAAQAEWLRTFLARHPITRDLVHWPEDPAGQAAWFERWNDLLPGPSAQLFNQPEEDDQEAASNFENLRNDPNADSNATLEELAANAQAAAERTFRWGSRSPPRPPGGSDAQNGNGFQNGNGVQNGSGAVRNVNGVQNGNGALSFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKS7</accession>
    <name>A0AAE0KKS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_398401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKS7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="67"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="538"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="919" mass="102740" checksum="64D56F62E3377BB5" modified="2024-05-29" version="1">MADFPSLRPGQYTPSQPGTPRPSSPSESQFTPSSNSFYTQNAAASSAVSVTSTTSRTSIGTYNDEFRFKTMIKYLNKQIVSNSWIPPDSERRYQDGFGVLYRRSRGHYVSFPEHVAPQLEACVQRLNLVIAFTMKPEMLDGILDSLSPGQTELRLMDGSQLQISDSLESMAPSNVKKFQYACLIRLEGILLLWHDDLQQIIPTATKLEEKLLALIWGTGSLPFGLIQPASLKTPSLYSSNMSIYNGGAGEKLMGGLGALPNDSSEALESDESIDALESLRRPVKRISAIFVGMAMCLAVILLFGTFISQLLIQVVMDGSYTRLALIACVPFLFCVSLFFFQVIFSNMFQIVGPIGGQTTNSRFYSPIKPSLRRAYMDGFTPPHMTIQMPVYKEGMESVIIPTVRSLQAAISYYESHGGSASIFINDDGLRVISEEEAQKRIDFYHDNHMGWVARPKHGQDGFQRKGKFKKASNMNFALNISQKVEQYLQEMVGAKCAAEGTDVIDEQEEEDMYQLALARALKENPKAQAAGNIRMGEYILIVDSDTRVPVDCLLYGAAEMFLSPEVAIIQHSTGVMQVTGDYFENGITFFTNMVYTAIRFSIGSGEVAPFVGHNAFLRWQAVQDVGVVESDGYIAYWSESHVSEDFDIALRLQIKGSMVRIASYHGDGFQEGVSLTIYDEIARWQKYAYGVSEMIFHPLHRWILKGPFTPLFYTFLGSNIMYSSKISIFAYMCSYFALASALLLTLLNYFLVGWFADTLDHAYMSSWQVFVSLIAVFNIMGHVALATLRYRNGERSFFGSLLENFKWTPMLTVFFGGLSFHVSGALLAHLFHVDMQWGATSKEKENSNFFAEIPKILQTFKYMYIFVILVGAAMIYLGLYAPRGWLITDFTAIVPLAVNLVSHALTPLVLNPSLMVFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLD2</accession>
    <name>A0AAE0KLD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_252269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110295" checksum="285FEF03087B6BC3" modified="2024-05-29" version="1">MDQGQPDSKRPRLSTASWSAGGAHHGVSLLHPTPSPTTGQLPHHPPSSTQYQQPAPHPFNRPPGPGEPHPPPHHPPPPSSSHQTPIDDRRHHEPERYPPMQEHRQLPHSPVHPAFPQYPPRDREPLVKADPGIDDTLPQLRRPHSTGNAADSMTPGTPHSALPPQYPDDKRHLSFDGGPQPAMYRQPSYPPQTPLSHTPTYDYPPQYGGSHSDFYGIHVSTASASGKRKAQRASQACDMCRQLKAKCDELKPCKSCKEKKVDCKYREAVPKQQDKVAADMLDTLMFLKNEFMTFGDRITRLEMAVKLVLPNIDIQPPGSDAMQEDDDRPGSPDSAHVEDNFSSSPGETMTGTQAPMGVIEARTITRNMEDETEAEPGPRVKPGVPAIPVNHTTLAALLLKWRSIENLVRHHLDAENVKFVDEFPIRQEEKRGLLRVWGRGEGLDSRVDKEANKEANNDLGVVEVHGDEQSDTGAPSPADCWGGISGSPGPADGKSTTLIGIQTLDFSEPTVWKYVKSYQDNIQNMHPLIIPVELNAMVKLFLDGIQQSLKPAKRSDIARFVTFSPMGAPEGGMGKRKRSSPGPDGAELPLPTPKAGKPTFQRSINNALVLLVLALGKICLIKDKKIPDVVPVGEPSHGSPVVRNGHAAGPPSPSQGSPPSYASHSHSSGLPSPKEGAERSVGGTGKSRRPSFQGSGGLPPVKSGPPRRNLDVIPGLDYFAYATDILGGQLAGTSLRHIHAYILAGLYHGQMGRVVESYAYIKEAGWALQIKMRPSLDRFKKLQENMPFSLKAVTEKSDNQLVFAFWTCLQLESDIIAELPLPQSHILAFEEIMPYPNIDILEYQGFDPHVLQSYLAQLYLRKSLNQIHQMLYNPENIQAQGVPSANIIEYIQNSLDLRFVPPTFKFKQSDAPAPDILSARLRAKYWGAQVITYRPFIRHILESNYISTDEPVGAAPKPEHVITPEMTEYAVKGIRALVESTRAFHGVADKRFIITNVFGTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N278</accession>
    <name>A0AAE0N278_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_564917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N278"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="807"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="896" mass="97068" checksum="ED1EC3728FEA20DE" modified="2024-05-29" version="1">MSTGETLDPTAALGYASTRGYDQIVAHLLPYTKTAAAPNLVTLLERMVCRAAVLGYVKQVSLFIDYGADPNAAPDNITPLQHATRNGHTSLVHCLLSNGKVDVDSKTGTDTDKPILLAVRKGYEPVAQRLLAAHADLNCLTMDGSKRTPLYLAAEHGHKAIVHHLLAAEDPAHRVLDNQSSSGTSPLIIACMKEYSEIAKLLLDTDASVKLCDSNGHTALYHTLRPGSENLAMQILERVSSVDEIKDIGDIFLRAAYLGFITIIRRCLDAGALQDRALLTGYSDREAYGRKALHGAAFKGRYHIVRLLLSLGADVDPQDSMDLTPLALAAEAGEADIVELLLAYSADARLKTTEGETIVSRVAKVSEDSSRHASVVKMLLDAGTDPMRLTITRGMPYTGLRPWESSRLSRPSYGIPPLTLSLLEVAELLISAGADPLGLDIDGWLPTHLASQSGNIALLELLWERNPESLEARANDGRTIIHFGLPNPESIRWLLGHQADGNGRDNTGCTPLMTAAIEGLDDAVHNLLDSGCSASTVQETAKITALHFAGKSDGVHVGRALLKNNPEILSYKDAANLSALHLAICSRSTDFVVMLLDEFYSKADKTCLRDLSAVGSDDGETPLISAVRRGHEGVVRRLVMLGAETEYRDKRADSALLEAVSGSNVTLEMLRALLDPNVPNHAKFNAGGGARGKFNTALSAAAFGGYDDIARFLLELPDSKADPNIPAGHFANALSAAVRSQTYELVTPLLEADTNVNATDIQGRSAFHIAAHRGAWDTIPLSGELRSFLSILADEEMDWDIEIKDSHGWTPLHWACRHNNSLDIVEALVQCGADFKHVTEEGWSPENISATHGALNIFDYVEQNLMPVEVSSFEDSTRKTDSDGREKKSRHRRWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2M4</accession>
    <name>A0AAE0N2M4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_515066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2M4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="193" mass="21490" checksum="5BA4C12424CECD7D" modified="2024-05-29" version="1">MAYDNFYFRNESAQHGSAKRLTTPPSPVLKLSPSALSEAQGIEVTWPEPRVIEVAYVKEPVYNDGLSGLGDEGGEETEEPAPDDDFLVSYDGAIECVGLRLTCGAARWLQTDSGSRVIEDQSLEKCLDPIALQVCHEPQAHAIGQFKPMQHPKLDSWAFYFNPRSDILWLNTDVTDNPNTLNELQAYYGKQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2W1</accession>
    <name>A0AAE0N2W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_72793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="532" mass="57326" checksum="055FCDD61D787E01" modified="2024-05-29" version="1">MIVPLPRLDSPPSLPLAIQWLNMAPVTCPSSIDWRSHTIENCKFFSRPDAVLSLVIAKEPLGTFKAIVLRAEDGQREALLSESGASIDEVLHALHVKSAEAVQNYISTNGFEFVPVLKKRSSSNNIPNDVDDASDNDSAFSGSASSTVTMSETGSVCESLSDNETVSVLSNGERPAKHDTRKKASKRSSKDKKTAEKAKARRSRSESSPRSPSRSLSRSSSQCRSCANEESEDEDGPSFRPSPPRFRFPRGRCPPPPPPPGWNTHSGMFAQPAMSRIPPPGFPSMPPSGFPSMPPPPPPPPPSAPSPSAPRPAPPPVPSCDLPSPLGPVQPKLDSRPLHGHSAFFPKRTPEPTEALHPVRLLIRWRGHGEHRALEQARLSVSGIRDAALKYIRRQIVVPYNTIPSYMWTMRATVRSATIDGEEYDISGYTGDQLYHLLDCSPSPSASLSAGSPGSVVNKVPRFEVEVETQPPPAMPRPPPGGGGGTSRGGHQPPTNNSNNGFHHHQSNMPPMPGMGGGQGPVPSHMQSQHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N440</accession>
    <name>A0AAE0N440_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N440"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="12779" checksum="3052169D212E05C0" modified="2024-05-29" version="1">MPPTPNPELRRQVIAVYKELLTLGRNYPQGFDFFRPRLHRAFMANANLSDEEEIRQGIARAEYVRKGLFACPLSPFLPLSLSISTMTQQLDLRRENEPFKADDDFSHIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N578</accession>
    <name>A0AAE0N578_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_441076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N578"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clr5" evidence="3">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="690" mass="77595" checksum="A9BD514623ACA652" modified="2024-05-29" version="1">MEIMDWTNQFDFGPNSQETPFSFASSTQTASASSAPMDSLFANPPQLESPQDSAQTPSPQANPADGQMAPPATKPRKRKAPTLPDDDWEPYKSHIIELHINDNLPLSEVRDKLETKFGFKAELRQYRFRISKWGLDKKVKPHEYQAIVRKRQRRKLVDTHRGELAFTVRGVEVDNQKIERWMKGRGISDHLPYALIPAASTPSAIDCETVLGEQRSPFPSTPNSTASRLATPTPATPSMQSRVIGTPVMALASPFSASYGEPPLSPALSDISVPRGPSSFGGQSPAPDNGLPVVWMQNLAPITPVLTNWAVSPPLFSEPRFPLVAGQTSHQMTAQPMPQRYLQANEDSLRDAIRQLEVIHGPHHFDTLAKMLELGVVLAEQGRFKSAEEITRSVIDAHPAGVGTTNLMIEALDQLGIVFSRQGRFSESLELFSKTFKTKTRRFGSEDPRTLLSMQSLADAYVHMDRLKKAEDLIRELMEICMRVFGNRSEKHTRAVYSLALSYHAQKRWGECELLSRQVIDVWVPTVGNEHRNTFTAKCLLAATYWEQGRWSEAGVLQLQVVTHERKNLGKEHPRTLMTMSRLVGTYMKVGRWTEAETLGLEVREAQERVLGKEHPDTLYSLHMLAELYLHQSRWEDARSMSSEVLEAMVKRFGKEHRDTLASARLLRSVYHAQGLEVEARSVEEKYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5H5</accession>
    <name>A0AAE0N5H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_310101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5H5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000338">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000034">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="13">
        <location>
            <begin position="300"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="507"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="811"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3370184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="996" mass="110885" checksum="2316BFE96E066DB5" modified="2024-05-29" version="1">MSLIYGRSIGRSWPRVGSIHPAFSSSRYPGFLRPCHHLDFQLRGLAAPAHRGYAESKLDLPSLDKKWRKTWDSIRDSTTRSEAGARLEGARNGWSDAQIGPGSTTDAEKKYILPMFPYPSGTLHLGHLRVYTIADVVARYHVLNGREVLLPMGWDAFGLPAENAAIERGINPATWTKTNISKMKEQLDVMNGSWDWSRELATCDPAFYKHTQSIFLRLHENGLAYQDEAEVNYDPIDKTVLANEQVDANGCSWRSGAKVEKRKLKQWFLRISKYRDSLLQDLGILAKDGAWPERVLAMQKNWLGKSVGASIKFPVLAFNQDVHVAIEVFTSRPDTLFGVQYLALASTHPIVTKLAKKDPGLQAFLDTLPGLPPDSKVGYLLPHIRAVNPLAYHEETPEATKKSLPVYVAPYVLGDYGEGAVMGVPGHDIRDHAFWKTHHYDEPVRLVLAASEDESTTALPNEPFVEHGVLTKQSGFYEGKSSQEAGQMLVSLLEPADLAKPVEKWRLRDWLISRQRYWGTPIPIIHCESCGAVPVPEEELPVALPDVEAHWAGGKNGNPLETLTEWVETTCPKCGGHAKRDTDTMDTFVDSSWYFMRFVDPHNSEVPFSPETAKSLLPVDIYIGGIEHAILHLLYARFIYKFLMASSTTQEYGVSNEIYEPFKRLVSQGMVHGKTYSDPSTGRFLKPDEVDLSDPSNPKVVATGEPTLVSFEKMSKSKYNGVDPTGFISQYGADATRAHMLFQAPVSEILDWDGGKVIGVTRWLGRVYDLVVKTQDTPVSTEFPTPKTYFEHTSKKLDSLGPEELARWDADSAIWRDVQKTILSVSASYDKVYTLNTIVSDLMSLTNTIIANDGASTFIQREALSALVRMAAPITPAFAEECWSILQPDAHSIFFCQQPLSALFPVIDGSLSLLQSRKQRCAIQVNGRLRFVVEIPQPPALEGDELRDWLIDEIKKTDEGKTKMSPTTDGSPASIDVASAKKIVVVKAGKLVNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N762</accession>
    <name>A0AAE0N762_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_485360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N762"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="44"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3372613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="399" mass="45639" checksum="04A3A6F58BFDF08E" modified="2024-05-29" version="1">MATQPPAPLPGLASHQKLDEECYENYDEKRFYPVKLGEIFKQRFLVVAKLGHGTVSTAWLCRDLQANFNYPRYFALKVSTSGHDYTHHDEVFISQHLTSLAGQPHPGRPLLRLVLDHWWIRGPYGAVHRCLLFEPLGMTIRQFRNTQPGRLFSMPLLQQSMGMIVLAVDALHRSGVVHTDISPSNILLGVDGHAVFARLEQDEIEHPSAGKILQDRTIYLSRKMPVTRGPWILTDFSAALRGRRFRGDCMPRRYRAPEVIMGMSWNTKVDIWSLVPFMWDLFEHRPLLTGKKEDGTLDDEALVAEMVSVMGPPPKAFLERSATCAKYWDANDNWIAAAPILSQPLESYVTWLHGRDKELLLQFTRRILRWLPEERPTAAELLGDEFFHTTSAMTLETHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8S4</accession>
    <name>A0AAE0N8S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_400712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001039">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3375027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="628" mass="69165" checksum="3F3C8D54C9505315" modified="2024-05-29" version="1">MPQAFSSTGRYSSNERRLTVIRKGPVTDYGATIVHWMRNRQPRYKGSYLGEFERPSPSYIVDMLPPYARTASPADSVPTRHLHSSLNKIKHPVNVVRWTPEGRRLLTASSSGEFTLWNGTGFNFETIMQAHDSAIRALAYSHSDDWLVSADHDGFIKYWQPNFNNVESIRGHQDPIRDLAFSPTDAKFVTASDDSTLRIFDFAGGIAESTLSGHGWDAKSCDWHPTKGLIVSGSKDHLVKLWDPRTGRCLTTLHGHKNTITKTVFERVQGFCLATSARDQTARVFDLRMMRDICLLRGHEKDISTVAWHPIHANLLSTGGSEGSLFHYLLDEPNTPAGQPASIAPYDCADPLVVPAQAIYPAHKIPFAHDFAIWSLDWHPLGHILASGSNDRITRFWSRSRPGEADSFNDRYHIGENAAEAQGTWDRRGGRHMRQVEEEQELEDEMDGLVDQKLPIKQPQSSFPGIPGLPQLGNGVVIPPPIIPGVGGAHPPLPPLPFPLPPGMHGVPPLPAGLDLKNPSDLAAIAEMMKKAGIPPPPPPGGHLPPGMLPPGLIPPPPLPGFGLPPGFPPPPPQILSQQQQQAQAQAQAQAAYEAEQTAESIRRRAPLPSQEESLRMEQSKGHYTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9I6</accession>
    <name>A0AAE0N9I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_266590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="175"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="621" mass="69817" checksum="E6C3DC1D602184E1" modified="2024-05-29" version="1">MVQSGQHPRHWPADRSVLDHSPDDSRFYETATIRPPPLTIDRALREHCQINVQSYFLAARLEDGSTRYFSGPRGLESAEIPDYFQMDTFLRYQRRTGSESFPEDTGFPHEEPYYRDTVGPEYYGRRSYHRRRTQGPDPYGDESRRTTRKRLRGNVRREPDDDEPAVIVTAKKGIKIGNAEEVCNFYDERFKSCQQTACKLIAKIFIKTIAPKKQSNNPYTSKDDKAPDWWPKAWGPTKDEKVRHKEPDHLWKKERVHLLIHILRMVTEPNHKQHKDIQKLGITVSKLEETTMDALSTWFADKDKPAQALKKTFLKEIFKVAKVEEQYKNDEIGWLSSSKKAHLKILIAIDAGTEVFVRVSDNAYQSDDETPLLKEEEIDLPVSSVRVSPPHAAGSHNTMSTMGNEHNPAAPNVQVASSFISEIPVRGPQYPSTMMPSELAPEQHTYVESGNMTVGGQAPLHASSTMQMQDILTGPHDSSRRPSLYSGQSDFSGPSGSGLYSTPWQQQQQHQQGTTAPGNASLYSSFPHQSAPQPPGTYVTQQSASATNQGQQYPFDGIPITPTMYRNGSVGQGPVVHGQQSYPTYLSQLSHDSGRAILNDNSNKGSNGTLKMPPLNRGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9K5</accession>
    <name>A0AAE0N9K5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_438488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9K5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="37325" checksum="C32ACDE7534E15B1" modified="2024-05-29" version="1">MASPVVSRSFGSQFLLLVRSSPATLCKHTQRPAPIRLVLYSSQTATKARPAMAPPPGKPAKAKTGAVPRPASSAKKNASSPILGNAAAAAAVAARRTVSSFAEQLAAKGTRTILYEAPSHFWYRFSCLSAGTFCVSYAVYQYWTIYLNPSEGLAWWVPQAFFIVCAFMASMGGYFALGTSRIVRSIESAGAAAAAQAATAAAATAAAASTPIYIEVSTRRVLPFLPPKRTLLLPAQVSLPFQMHRVLAGEATPLSTTKHLSVAAQRAEREAKAKARQYELDHIMTAPFRDAKSGMNTAWSQVRRAFDRGGFAKIRLKGVNYKIDVTGGWALDNGRAMDRLLTVRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NA61</accession>
    <name>A0AAE0NA61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_267268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NA61"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="35788" checksum="465B4A269A35A6E3" modified="2024-05-29" version="1">MESSFTDFEKRFVLAEMIKASNMDVAVLVDFIKLHQIQPNWLAMQLPGGRNMNQCLYAAETMFNMQIPPPAIQPLKRKSLGDLGDHIPKKLAAIHPTLGDTAPYAVPRNFGLQPAGAVQPVSIQPRPAGYTPIAQAPNPPSSGPTPSSAPPAGRRRGRPPKVDATRQNPPQMIAYQPITPAPIAPSPGPQNIAPQPRSPGPSQAPGGHALYQIQTTSIPELKPKRKGRPSAVDKQSLPETPPGTAGGPSSSETCSRPSDGPATKYQDWREIAPRREHDANSGPIPREPPLPSMNSPLPPSRNLHAALGVGTHVRETTSTTLEQQARQGGHTAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBP4</accession>
    <name>A0AAE0NBP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_477190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBP4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042261816" evidence="1">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="163" mass="16936" checksum="74BD567CA1585712" modified="2024-05-29" version="1">MHLSAVLVSLLGATVMAADDLRPCGFKIAPCPPGTTCVAQDPKCPPIRGENCLGFCTPTKPTTTLSTKTKTKITSTKAPRPTYPPCGGFRIQQTCPEKDQICIDDPYSGGCGMACDAPGICVKPTFCGGIAGFRCADGKMCIDDPRDDCDVEHGGADCGGICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC54</accession>
    <name>A0AAE0NC54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_480297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="194" mass="21938" checksum="BBF40B21BE366272" modified="2024-05-29" version="1">MIPSIITGRKQGLYRLSITAACQNKIRMPRLSWRKRWSHIDALPLPAALIPFCESLVWVAWSPGVDGDTRIGKPWRPAALVSVVASLIADSPDQRGSNDQTMPTERCQEPEDDDRPDGAYHKVIISSGWYRVRAIKHDTDYLYPPRGDNLPRLAFNSVMRKLETALDPGCYLHAPMQPARRPCLSWKGIRPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC62</accession>
    <name>A0AAE0NC62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_244662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC62"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="148" mass="15630" checksum="57742C2F57F4DFC7" modified="2024-05-29" version="1">MAAVTVPAEYGYVLLATVSTFFVNTYHVVLTSKHRKASGIKYPVTYATEEQAAKDPKAFAFNCAQRAHANFTETLTPAVGAILIAGLRFPLAAAGLGAVWSVARAAYASGYAAYGPQARQKGGIPSTIALFSLYLTAAYSAISFVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCH6</accession>
    <name>A0AAE0NCH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_495920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCH6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="463" mass="48811" checksum="678AC20B6E03C428" modified="2024-05-29" version="1">MEQLPSSSTGAGTGRPWAPTRKRSASGAGGLLSKIPFIRSSAEHLRPRSSRRSADGNEPAATFPPTPSFRSIPSETSISSQQQNGSLAGPSPISLAILQQQTQQQQKTRRRRGSLRKVALLGRGAQRERREAKALAVDTKYQVDGAYNSNAQREPAGPGLIVSSSSPPNKLTIKTLTPPGTAGFEGGPGEDGYGLGISDITPRPSMDGYASRSATSLSLSNPDATPRAPPAPMTLPKTAPDLTTDSFVTSPSISYSTTDDEDGLLHMTGPPSSRPSTNPSLSLSSSSVSLLRPERASLSSGSEGYLPTLQHGRGLTGGGSSTGSGSGGLAPPGATSIQRRRSTIQRAKSPLALTALAGLSTTPLPPPDADWDYSETEKWGWVVLVVTWTVFVTGMGSCLGVWSWAWDVGTTPYAPPEFEDDPTLPIVGYYPALIILTAIMAWVWVVVAWVGMKYFRHARVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ND56</accession>
    <name>A0AAE0ND56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_244267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ND56"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="22868" checksum="0CF2B08B3D138D67" modified="2024-05-29" version="1">MGGVGEKVGGVVSMLCDTQQMSFYVGRQKGLVLNKENVSRGIIEHPLLFPHRYHTQPGLTHTHTHTHTHTHTRTCTHTRTLASQTAAINKVVVYPTVVSLDLSYELICDNIEVTSLLVSSCSCIFSDPSLFALVWLGFDWLTPSDCVQIENKTDMQERRKDKREARAEQALSVVFAVELHRRRSQEVTHAFMPTTHTYVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG95</accession>
    <name>A0AAE0NG95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_193852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG95"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="256" mass="28123" checksum="1A16B11D18C8ED3F" modified="2024-05-29" version="1">MPLHHPQIHSVQIYHKPGKLIIADATVDPPHRIDLLADMDWNLGATPTSASQAQPIRNVPTAGNKFLAPPPHWFQRSKPLETRQPAFLLRTGPLGGKRIQHSGKARITNRRAEAGLVHIHSIPSTPPSLLRRQVQVGERHISPKLPIRPTRRSCLSERHIRHLPLHHRLAKSPLIFGEAVIDTWSCPASEVAVLSCPFGLTMHVLCPFVSLGLIAVCDVFGGAGLLCCGQRSSAYHCPSWLSCSGNEKASTETWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGJ8</accession>
    <name>A0AAE0NGJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_450450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGJ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="27901" checksum="42B34E7448F7BE0B" modified="2024-05-29" version="1">MHIADLLGEPEPVEAESLPSGTTTESCDLTGIANDALIAISDPMTNDDIIVINNLMANGDLITNGDLMANADFTTNGDLKTSIDPPAAKETETLRLPRLCEVVMNADDDCTNSLESLSQDPNNALAIQLSNDDRAGLIFWYCNWETNLSRAIANYELLVLYGPHASLMPLRMESMYGTDVPNFPRTLRHFENMSEFETDRILEHLDIRYPKNARVRPLSEKKELLHHKWIRYPVGIARIAQNPQTYQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHG8</accession>
    <name>A0AAE0NHG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_475949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHG8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="41589" checksum="2426B800D32B6E59" modified="2024-05-29" version="1">MPDDEGAGFQEMMRSAGSSQPGIGTYNAQQLGIDFAKLPQLPFYSKLYAYTQSWYQHEITKSVNQASVFVRRPLTPDERDAIAFHTARQHSIEATWDPPLRVVAGLYFENRGRATLRFPFITPNPQNYHPDVFPSLRMPYLRGFQANIAWSVLRFFVYSEALDFAIRPFLVAYSRTISAVGLTGDQRLSGWRDEFLAKVKKGGPGLPSSTPAPVSHQDASQDTNQDNQDSPSSFGGREESSEQPAKSFNATAWDRRRAQAQAPVAASEEDDDAFLSEDYDDASPLAPSVRHQQQQPQKSSGGSAWDRLRSQAAPSGGKGKAPRETPQASSENNEYVYAPKDDNSVSKAEAQRKFDEMLERERSGKSDSSDRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI21</accession>
    <name>A0AAE0NI21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_216312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI21"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="116" mass="12011" checksum="8BB015B52851B57D" modified="2024-05-29" version="1">MSSLPRRQNSTNPRPGSSAFPRTPRSNAPPPRRSTATARPSPPAGVAAGPPRQSPLRSSALESATKTQMNQTMAIAMMGSLPVNPLPLFLPIPLGVTMLVGSSSNNKSAASGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP51</accession>
    <name>A0AAE0NP51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_449209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118582" checksum="03AE8DC13CB947DD" modified="2024-05-29" version="1">MELTLAHRDLDGVLQWLRPSAGGQVVQQADEPMQGTHQWINSNICITEWLDVESQKILFVEGRPGFGKSVLAARLAEICRQRSDSPLVILYEFSNQSGPSTLAASILSQLLHCPEIQPDDKALKLIVTELQELGNENRLGPSGCRFIKLWDLALRALAIPRTKWAQVFVIVDGLDQYDFNTNISLMGFLESLKDSSRVARVRVAVFTRPQCEILSFASSFPSRCLQVSLTEELLASDIELFAANKFDSLQIPSRFNDMTLERIRQDAKGSFLWAKLLLKYLSEPWTEIEYLERLRGCPPDLSSTYDTMLEDGAALFTKDTPGAAARHRFSQQRRKTLLLVCEAREPLSLVEIGRAVSIGHYNVEKTLMDRCKPLLFVSEARLHFIHASAKEYLTDQSRLRFVTGEEGAILFRASDSHRSLAWECLSCLLDPEYAEKGRIGYFIHRSFGKFLQEELIPEPSRGLSFRYAARHWDFHLTAIEDPDAELLETTRQFIDSFQFAFWSEWSIERTGNTSRVFDVWRALRTWTASLPKDKQALICLDDYFVGPYLALSEAYRDAEAEDKVLQWLALMRVGRYYVDKGETEKAMPIRREVKDGLIAVLGTSHPLTLRARTDYGLSQTFEGNYQEAYDEFKAIVEIEENSYGETSKELYRTLMAMGETELYLLLFHDSVSTQEKAALGFLKFYSQDSKQYLSARMWLCYPLIELGKLDVAFEILFYVFQKRTEGYGPDDMFAASSRFSMGGIQRKQGNREAIKSLEEAFRVRHQLYNLTSMWALDFAIELLIAYRDFGEEAKAAKLLEDLDSEGAGDRLFNRHCQVEHVRSLLRWDSGKRDQAIDLLQGLLIAADREDYNRALLWIALDLALMLRARGGEGDNHQAEANFDHILVDCKLSSSSSHRCVRQRLIDKKSGRNSGNAETHSVRVIEALASWRSGAKDKEQHTSDDKSAREEVYNSGDMEPDPPHTLRLAEKALTLVRNRKFAEVDELMREEQFDWFRVQDLWLWSGGPAADTSWMRPPLGVTSVIFHGFTAAAPTAAEEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP82</accession>
    <name>A0AAE0NP82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_543388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP82"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF4">
        <property type="entry name" value="BLR3857 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="629" mass="69281" checksum="7003A831717096BC" modified="2024-05-29" version="1">MGSILSSPAAPSNPTPVHPLKTLKFDAEGIAKKYSEERAKRIRDDGLSQFKPATGAFSRFKDDAVAPVVPRDPITADTTVVIVGGGFAGLVTAVQLKLRGVTDIRILDRAGGFGGTWYWNQYPGAACDLESDIYLPFLEETGYIPAERFPSASEILTHVERIAAKWDLTPQAHFHTGITSAAWDEPARRWQIRTDRSDHFTAQFVVLATGTFHEPKLPGIPGIETFEGHQFHSGRWNFDITGGDTKDYHSLTKLAGKTVGIIGTGASGVQLVPPLARSAKKLYVFQRTPSSVTPRENWRRDPAKAALSLKPGWQRSQMDHFANIMQGDDTSDNISTAAEGFDVFTMQAILKEARDAGVTAPIPPDQIPELIQLADLRLMERLRKIVQDTVLDGATAETLKPWFSFFCKRPAFNNEYLPAFNRPNVELVDTGGKGVSHLTKTGVVVPNGREYGVDLLVYATGFDFEIGAGFFRRTGIHLTGTSGQTPDEAWEQREPNPGPSTLFGIHSRGFPNLFTIGPAQAGVTANWTHTAYIAGEHIADVVAALVRDGTYEVVEPTAEAEEDWGKQVEAGAEMRLMFHKGCPPGYYNKEGKPEEIPARWAYYPKGIVAWGKLMKEWREEGGWKGMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPJ8</accession>
    <name>A0AAE0NPJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_179708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPJ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041969388" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="35568" checksum="5CF7D9A54EA2F841" modified="2024-05-29" version="1">MHLSCALPLAAFLALAEAHGVILGAQGESGSPPSVGFQVNEGIARNCTTISPCQLDATIIRDAEILANVVNKCGRTQLAGNIDIGENTENALAANAVTQVKSGSKITVTIHQVNADGAGPYVCDLDETSNSGLISQNLTVTNNVPGVNGLSQAKAQDFNITVTMPDKFTCTGASTGDICTVRCRNNAVAGPFGGCFAVQQIDTTPKVNTPENIATADPLDGVLGQVAVNIQDLPKAIKANQDAGSTQAEQNAAAVKAILGDSVVTKASPTTTPLGVNGGAAGGAGAVATPVTDSAAGLVSTTTAAAAATTTTKASGRSKGNKGNANAGTANTANTGNTANAGNKANTGNTNNKANSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD7</accession>
    <name>A0AAE0NSD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_540891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="208" mass="22421" checksum="397386F85F64374D" modified="2024-05-29" version="1">MIDDAQGIVSIVELVLNVPSLILALIICARHGSSRSSGWIYTVLLCLVRMVGASCHLLTYSNSSTRLIKATLIIEEIGLSPLLLAALGLISRFIDWVNIGSAHTRLDVAHFRILQLLILLATVLCVVGGTSTKPGPDGASERAIAVSVALALPFTAIRLTFLVLVTFLHNDTFRLLHGSLGARIAMVPIPEHIVIDSWTFTVSIPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT59</accession>
    <name>A0AAE0NT59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT59"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="56139" checksum="A759A566EF81AA9D" modified="2024-05-29" version="1">MSSTSPQSPPRRPRLSLQIKALAHGASVQTSRNLAAAVDVTSPTAFNTLSNVYATTVDRSTPIQEKPPTNALTGGKPVLRLQTQDGASAKDRRLHTPYLGPLLDTPLSAQPSSPATGKEVCFPSSMTATPPMSAQAQEQNSQVFTFDGSSTTPVTARISYGGQTPTSHTPRRRTTMPANPMNLPYTHPRSLRSILRNSPLPPLSTKSPVSPRRQSLRLQEKALRRVAYNSPLCETISTSLYTKSHVDLLSEDATPTTPSMASDDDVLDQTMAYTGNETRDGGQTPGPFEEMRRRMTTLSTSTPVTATPLSGGIRKRSKKREKKRRWVWTIGQESEEGEETGDITSSVGNSTPASSKKEVLAVPLIAVPSPKTRTRMARSGASLEIPVIATNIPPAARAAPYKHVLTPAPAPSPRATPEPFTAVVEPPTPSVDSMASQSSLFERESFGDVEMSDASSVMSDYEDIKTATQASVLGIDMDIDMGMGGATPTLTARPGMYTAEENRSWAPWAFSMQQPDRAETCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTQ7</accession>
    <name>A0AAE0NTQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_159194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTQ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041945640" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9813" checksum="6183BBF79F99EBCB" modified="2024-05-29" version="1">MRRPIIIASLAFLIVHMRPWRLSIGKLVRRDAELKNLSTFWRRRVSSGCNELVTRNYPICDATQGHTMPRYSRLGSELSIDKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTY7</accession>
    <name>A0AAE0NTY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron permease FTR1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_470491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="40814" checksum="2473ED5C8AE36432" modified="2024-05-29" version="1">MAVDVFSVPIFLVVFREALETVIIISVLLAFLKQTLDGPNRDPQVYRKLVWQVWLGTGLGFFICFAVGGAVIGVFYTSGANKWEGTELNYEGAFSLIAAIIITIVGAALLRIGKMQEKWRVKLAVAMEEPIRIGSTKGSIKRFFEKYAMFILPFITVLREGIEAIVFVAGVTFSAPASAVPLPVIMGLLVGAVVGYILYKGGSSTRLQIFLVFSTCLLYLVAAGLFSRAVWYFEAQKWNNAVGGDAAEVGDGPGSYDIDKSVWHVNCCSPTLNGGSGWGFFNAILGWTNSATYGSVLAYNLYWIFVIVMFIVMRYREVKGHYPLMRAKAPLTQTEATKTHDSENEAPVPSGSQSREEIAESKAVNTHTSKAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXW7</accession>
    <name>A0AAE0NXW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_391239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXW7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="429"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="779" mass="82786" checksum="708A8E51E18D8FCD" modified="2024-05-29" version="1">MSGAKFEEPVYKVYEPGYRTRRTIIVDEEIESPETLTIHLEEEAERNGGDLTGDAPTSLLSMSAFKAQAPQLHGYADSAYSQYAAQPYSTQQTENAASQINQLAFAANTAATGHYLAAQHASSANVNVLSCHPNVGAYGTKVSLKVTSHYDLVSGTMPTPYVSVMFGSQRCQAQVMRSSLDGTGTCTYTVTAEAPQFLSTSCPSLSNVPLTLLIEGNNGEELGRASNVGTFSYHHAAGAGGGVGMGGAGDTSTPDLESPKTRSPAHQHQASPPNTSVALHGRIDTTNPTSHHGIASNPATSTYGFPPSVSAATAAAQAHAHAQAAQVQSEFAYSQGHNMLSAYRTTASYPDHYPRAPPILRSPLGATGWTPFPNHPSTSIAHATSSVMTRSGVAYQHPNPAAPQLFRTKPNAGGSSSGGYSPYGVQSLKAELKICGDLDTMTKNWTQEEWESKRRLVLFKKSQSGSVVTINFRHVSPAERPPHSMCISCIWWEEKKECYVTSVDTIALLEHLLVAPNKFCVEEKNRIRRNLEGFQPSTVSKSKIESEEFFKLIMTFPAPKPRNIEKDVKVFSWNKLSLALRKIISKYSTSPAGIATPSGSPHLVTSASVSSPMAYQTLPPTPLSASSTAAGDSATLAGYGSAATHHHNESVSSPRPLSGGSAWQPYASSSSRTMSPAPKGTNSPIPSSGLRLSTLPAVYDSRGTAQSLVSPYSMSSPAHHSPHHGHGSYGQTGGVPVSQSQTRSWDAYPVSTESFPSQTSHAHNQVYSGGAYGDGVQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYB8</accession>
    <name>A0AAE0NYB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_106615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYB8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="647" mass="63347" checksum="55A1164C03E81AC7" modified="2024-05-29" version="1">MTIRFLGNRFIWCRSDTHQNAWAPFGPGFCLSLCRLDFLETMLVIRILWLQAGLAAAQLGLDGFLGGGDATTTDGSVAVAEDPATAAAASSAAPAGGLLDGILGAQAVSSNAASPTPAATTDGGLLSPVLDPLVGPSGLLGGGDATTPAPVAAPEPVITLTPDPVVSSPEPVVATPSEPAAPVVPVVPEPAAPIVPEPVIPVASPTPDLPAPEQTPVEPVVPVVAPEPTPDVPETTAPEPVVTPDVPTPAPVVVEPATTPVVEPVTAPPAVEPLPATPGVPTVVPSPEAPAQEPAASPATSPAAAPAVPVVAPAADAPANSPASSPAAPVVAIPAPAVAAPSANTPGAPTAAAPPAVFVPPGSPAAASPVNAAPAATQAVLSPAGGASAASPSAETPAAVVSIASAANPNPANAAATFLSVFVPPGQATAIAVLAATPTPGAIGTSPSSGGATTNPDGTPNTGGTTNAGTPGVLSGDPTSNSPNSGISEVAQPSSLAPGTKIALGVAGGAAGLTALVICTWLLWRRRMRSGRGRVKFGPFGGGGGHSRSTSSTEEGHGGVADKQKMDWESDHNMPFDFGLYRQQSMREAHSAASTRAEAPPIVVGDEKKELEVLLEDSREEMDLGEAKQVVSGPILGRSPSYKASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYM5</accession>
    <name>A0AAE0NYM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_519461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYM5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="374"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51839" checksum="C3A2DA86AA89F809" modified="2024-05-29" version="1">MVLKLRRVIDKEKMADNSEPVNGINGAGGAAHAINGNKDAPENMPALEGGTGEAPAAEADDAPFSWLRPHPIFVIALIGKEETPFGIQKDFLVSKSAFYKKYFTENPQTELENVVNLPDTPVEVFAFAQNFLYTGQVCPSPDNLPSYDVLIGVWKLGHDLGIEGLCDATLAAMAECRRITQHIPATPLLVQVWKDTPEGSSIRKLLLSWAAEYMRSSDSRAEFARSLPQEVLSELVVAMSSLDTTPVVQVNAAREEGPALAAPAPPPPPAPVPARRVHYIETDEKDEELTRPPAKKQRHSDVLPNGSGLLASKPPAKKPGPRVSLPSAKPVVKRRSSAFLGDAKFSTDKKLNFCADLLTRMLSGPGFWTRLVGPFKEPVDPVSDGVPDYLTKVQRPMDLGTMKAKMDRREYADETEFLADMNQIFSNCYAYWSKKDPMWGACERLQKTFEEKYSQMNKWISKMEGDEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYT6</accession>
    <name>A0AAE0NYT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_464929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYT6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="316"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="437" mass="48099" checksum="AC15E40F9C1D0A90" modified="2024-05-29" version="1">MDEVTKSTAALKLAADHSSRDSKDEVTDPLAFMPALSPGRAPYHNHLKKMTFEETVADIKSHPLFMTELDPDATENSDELAALQALAYEGTPLENAANFKDQGNECFRERRWADAREFYAKGIAVLVVEEQRRKLRAKMGADKVPAPAAAAGPGEVQLEGKDEGENDNDPEEIRKQRVLLEQLYGNRAACHLELRNYRSCTLDCAGALRLNPSNVKALYRSAKALLAVGRIAEADDACARGLEVDPDNAALRAVAKDIIAQSEAETAKRRAEAERVETARRHELLRRAALKARNIATRATGKPPEMEDARIQLVPDPGDPTSALSFPTLLLYPADLETDFIKAFNETETLDQHFGYVFPLPWDREGVYSPNGVECYMETTTGGLIKVGRKVSLLKVLSTGSVEVVDELVKIFVLPKAKAEGWVKDFKARKAAEKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYX8</accession>
    <name>A0AAE0NYX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_107989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1420"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1650"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1856" mass="202473" checksum="A6BA4F5080659791" modified="2024-05-29" version="1">MASSPMSRGDPRQARLEQLARAWGVSSPAPLVLPNPSHPPSFRGPNDDFYAEDLLKRQRLAASQDKSSQGGIKRAFSSNNNKKAWEPKEIGDALEAHINKLGAPGVAEALIDKLRQAGGNLNVASIKNRTSLITRKKSTESTERSRILQTAVENRQIDMVSLLVHHADPHNLDAALPAAIRTRDVAMVRLLVQRGASASQTQDGQDAFRQACITGGHADIVGLILQSEGRPTPGWLCMCMVDAARIGCVETVLRLSRSQADGEYQKADALRTAISQCRVDVALAILTGLKPPISGGHGLAESFTKLFEHPTIGPNEKMTLTEALLCAGAEGDAVSDALYKACDAGFYEMVDLLVSYGASVEFQNAVMVRDAISRGNSGLVQILLNEKSTFSPTYASECVKHIPKAIAPEERHAILSLLLRKGAVGTPLNDALVDSVQMNDLQSVELLVTPFFPGRTPTTTPDTQAPSRRMVYDRHHMAAVDYNNGVALDIAIRKANLPMIKQLLVGKPSSQTLQHVFPLVIGLPTADRYHVTELFLSAGVTGPCVAAALQRAIEAVPPHRDERLISLLLRHNPDVNYNDGAGILAAVTLQDLPLLEQLLSKRPSPQTTAAAMAKVMAVTNPTIRFNMTRLLIAAGAGLEGTGISEALKQLLGVNPIDMHLLGLLVEQGRGDANFDHGAPVVRAIENHHDPVVLDVVLQHGKAGPEALSRGLDALFKLPTDPAKVAKINSILRRTQQKDLIDNGLMKEVELLLKEPLDRRPLAVVQSLLSVGADVNFNNAKALCSAVEATETRLVDLLLSAKPVHTSLAQALSKAMTKVADPKERLILTKQLIDARVPNSETKRALKFAIVNYPSDLPLIGLLAGHADSTDGEALKVAIQYEHVEIANLVLGKTPKKYSASVLESAFQQAMAVNDRVKRLSFSSALLQSGVSGPVVSNALLTAASDGDIDLGAVLVSSGASVEHQEGQAVIEACGAGAPDVLGMLLTSEVEVNKRTLEKGFQAATQVGNLDKRAEVFRLLLEKGVTGDVVDAQLVSAAKFGDEGEPLVRLLLDFGACVDYNSGEAIWNSTRSAMLGSLKMMLGLDGAGTNQKRPSAATMLRALKASRKLSRDPRYQVIEWLFEAGLPPSEEIDIALNRAVKDEPDLRLVQLLLRHGASPLANACETLTDASQLLLVDILAVLLESEIPERDVSWAFRQAFTPETATTWLSEQGFQVAKMLLDKGAQGESLTMALSFAIDSYGSENDSVARQFCCLLLRAKVDVNFQQGLVLQKAAKIADSELIHQVLEQRPNSLAVSMAFPYIFDSDLLEDETLQLMLMFTEYHHGEERLDTLFAHPQSEPVVFRALDKFPRSVRILEALLDAGFYHDQATSIRVLDDLEENETVTLLFWALLQPQKRISSNVILLLIERHANPNFESPVSKMTPLMLAIQSRRQDLVKQLLLEGADVNVEDITGNTAMTMASKIGGDVGTLIMKMILEADPSINDGSLHNSARELNLDALRILVRCGHDVDYPSTLHDGRSALGELCLNAAKEGPISPAKEKLMEKVMSFLIDSGTDLTLQSDGKTVLLLALHSADPVPTTRALLKVGLWKQVNQKYNHYKAGNYTYSPSQYVAQLFPDSEVKSELITLLKANRAIDVFYANEGPQPEGAVNLPEELLEAERKRRALEERIAIENQEHERSIQRTKELAQVHNQVFLTRAELEDARARRQLEQDLSGARARQAIEEEGFAAAFHRKKAEREASLLHEQRLTEAGLSRNRLIADSQLEIDNSRRQKAIEWEKQHANLQLTNAKQLSAVRIEERQAVERFDAASDARTIKRMTEHKKLVDSQGALATKLANGGVDQRRQIGYITGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYY2</accession>
    <name>A0AAE0NYY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_109549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYY2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000033">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF38">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="450" mass="49355" checksum="600E068E72C6B8B7" modified="2024-05-29" version="1">MKFFKSARPVAAAVGAAIITAGPPKGLNISEPSSIQSVAKTIAADTMRYYHGNAKEFVDLDAPYYWWECGALMGAMLDYSHYTNDTTYDKTIATALLAQVGPEFNYMLPEHFGDEGNDDLAFWGFAVMSAAERNFPQPESSIPPWLNLGENIWNSLASRWNTTHCGGGLLWQIFASNPNGLDYKNTVSNGGFFQLSARLARATGNQTYLDWANKVWDWTKEVGMIDEEYNVLDGASARKNCKDVNPVSFSYSASIYMYGAAVLADHTKDPKWTERTTRILEAARSFFSPFENATNIMYEHACEQVDKCNVDMRSFKGYFSRFTYASALYVPSILPTVTELLHTSAAAAAKSCTGGKNGTSCGHKWYVGGFDGQTGLGEEMCALETIHGLLVDKAPRPFKGEDIKVIRTFATPSPTATPSTNPNPKPDAAGPAATPEATQSSAATQRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ03</accession>
    <name>A0AAE0NZ03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_465152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ03"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="573" mass="63902" checksum="E58FC6E19DE7BE13" modified="2024-05-29" version="1">MYVGVAIRMAQALGLGDGDKEQLKPFRSQRSAPQPPKEPSSQVSIAKEIRRRTMFSCLILDRLLGCGKGRVSTIRAEDLQIQLPCSEIAFDLSEDVYTGFLKPTPEEAARPVNDSVLSRFVRLIDIWGEISKWSFAGGRFTEDNPPWKKESSFYQLREKLEAFYKDLPVLLQWSTSNYYKHENHQASSVYVSMHMLGAVCRIMLHREYIPFIAIRCERPVGPLDEPTFAKGEEPPEFWDISAEEIFHAARDIVDLIDICRDKLPMSALVLFSVWTAAFVGIYAVSFPHMDTKHHMLPTEEEAALESDVTKCGSTGSTFKTLSHMSGWLKMAETYVGYFRDMVDYYCKIKVVYEKHNDKKGQEPDGKLSVRLGGGGLEEWKQQGPKIVNNGEISAPEDDSHGVTRDSTMEPGSVGPDNGYQLDSNTPRSTSLSFTPINSGPHQHPQQESDPMDTRVDGLPSSAVSNWAFQQQQPPIQNSPQSSYAMPSPQMAQTPAGVPPTLTTLHFIPNLPVYGSSHELEEYMAANQSLPWSVVPGGIDQFAHGPVFEVEENGNMFWGAVTDPTPLQQVGGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ29</accession>
    <name>A0AAE0NZ29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_464672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ29"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000025">
        <property type="entry name" value="NADP(+)-dependent glycerol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="325" mass="36183" checksum="6229721B1CA87786" modified="2024-05-29" version="1">MAPTPASSKVYTLNNGVTIPAVGFGTFANEGAKGETYRAVTAALEAGYRHLDCAWFYGNEDEVGDAVRDFVAKNPSVTRKDIFICTKVWNHLHEPEDVKWSFESSCSSLKVDYIDLFLVHWPIAAEKNADRTPKIGPDGKYVINKALTDNPEPTWRAMEELADSGKARAIGVSNWTIPRLQQLLKFARIKPAVNQIEIHPFLPNSELVDFCFAHQILPAAYSPLGSQNQVPSTGETVREDLTLNAVAKRSGHNLAQVLIAWGLRRGYIVLPKSSTPSRIESNLQVPELNDEDFQAIEDVARGRHVRFVNMKGTFGYDLWPNETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ51</accession>
    <name>A0AAE0NZ51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_390507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ51"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="242"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="735" mass="81717" checksum="63135219605594AD" modified="2024-05-29" version="1">MELDIDNPRGAKRKADELDGDKAPRRIRALDQDVVNKIAAGEIIVAPVQALKELIENAVDAGSTALEVLVKEGGLKLLQITDNGSGIDKEDLSILCERFTTSKLQKFEDLQTIATYGFRGEALASISHIAHLSVTTKTRDSSCAWRAHYDSGRLAPAKTGQPSNPKPVAGRQGTQITVEDLFYNVPTRRRAFRSASDEYNKIIDMVGKYAVHCSHVAFSCKKHGESSTSIAIPANASSIDRIRQLYGGSVANELINYSTSDDRWGFKCNGLATNANYSIKKTILLLFINHRCVESSNIRKAIEQTYSAFLPKNGHPFVYLSLEIDPRRVDVNVHPTKREVNFLNEDEIIQAICEHIRSKLAAVDTSRTFLTQTLLPGGAWSNSDSQQPVTATATPSKTGVMGSRKTPNRPYENNLVRTDTNLRKITSMLPPASGGSKTGAVAQSSAARQNQDVEVIEYETVDREVNSCKLVSVRELRAEVREDMHHELTDIFSNHTFVGVVDEQRRIAAMQGGVKLFLVDYGRVCFEYFYQVGLTDFANFGAIRFSPPLDIRELLNLAAERELEAAAKAGDEGFDVKKVVERSATQLIERREMLLEYFEFEISPTGELHSIPLLVKGYTPAIVKLPRFLLRLGPHVKWPNEKECFRTLLKELASFYVPEQLPPTPGAEENGSGEGDEANIDPQLKARRDHVRRALEHVLFPAFKKRLVATKSLMKGGAVVEVANLKGLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZB7</accession>
    <name>A0AAE0NZB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_428962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZB7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="167"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="823" mass="91754" checksum="9412BE9A88F879CC" modified="2024-05-29" version="1">MPRVRPATTGYERLAQAEDLSDDSDDDPLAYSSASLQPASAPRYAAITQPRPHSGMTSPKLSGARGASRSGRHRGRRVRRNSGVDLKAINARLERWADEIASKFKRGRAKKTGDEDERLEIHHSVFQPPEGVRPVTAEMLARPEPGYMTKAEFEVIVGSVRTAIQQGVHPRMIAQGSSGSYFARNTEGRVVGVFKPKDEEPYAAGNPKWNKWIHRNLFPCCFGRACLIPNLSYVSEAAAYVLDAQLRTHMVPYTDVVNLSSKSFHYPFWDRYNFSRNKKPLPAKPGSFQVFLKGFKDANIFLREHPWPDQYLSGFRTNDPHRKRKKRWADSCRPSAGAAADDGESDDGQDSPQPSTPGPGNFAWTPSLKQSFREELEKLVILDYIMRNTDRGLDNWMIKVDWETEEVSIVSEPVHLNMDDEDPATAELGPRPVDLSQREPGKTRASYPYRTQKPMDASTPVGGSSSNNRGPKITIGAIDNSLSWPWKHPDAWRSFPFGWLFLPVDLIGRPFSQKTRDHFLPLLTSTQWWSQTQLALRRVFQIDSDFQERMFAKQIAVMKGQAWNVVETLKTADHGPLELTRRAKVCVWDDLVDVPIAVPMRLTSSEMRRRAESDNMFFATGIEEEEMDIGAVASSAPQPPTAAADLLGIATPADLPHPGRFEMSSPSLLADDTTPEDGGGLLNGSTPASASVPITVDNDDKRQQQRPQLGRTSASHGAPQRSLNMYSPERQREHQRRFSFATAAGRRNSNSIASQLFYGSNQRASHDNYFGNGTAGGGDDDDVDELEGDLGYAAAEGMEGNQRKVIVERLEPVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZQ6</accession>
    <name>A0AAE0NZQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_121353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZQ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="838" mass="93420" checksum="08F1811A585B2A57" modified="2024-05-29" version="1">MALWPFRRKSRRKRARANTAEQEEIRGRAIDPTIPPRSQTLPDVIASVVGSAPTQPAKKQRTSPNKLQRRPRTYSFSPGREDSIKVDRKTGARSRQTADFRAPRDDTWQTGARGVATMNEDAFQRMPTLHNKRDGDHLPRKKSSKKRRKDDQLREAEIKAMSNFVPVRPATDDWAAGRPMKKDSRRVKTGFGFGFRGSSRQEWEKYNRSSDISVPESIHSSLSSDSEHISFRVSALEALAPRPTLHYTTHPRPGAPAGDRGAGLFRRSSQQQKKLSAPIPEATLKAHKRIDNLADDLSASDLRELMERDKRRRERKRQRDEEKLNQKLARRVEYQRFAEAEAARQGRDSPPNLERGVLGREAIGLGIDPASAVVTSSSRRESRESSRQRGKRPADDDEVDVDLAESRPPHPLAAFHRISSIPLQTPQSPADETEDIVQQKIPPLTSPRSRSSFLRYGLSRSKSPQLSEVKTELSEPMQKGSETSSSKNPLSWSSFFRWANKHKRNSAGPSSFSNTSRDSMQTTQLPTPPVSFAPRRVSAGVPKRTMSRFREDLPELPLSPPDSRLQSPEVDPIPPTIAETSPDRNINNDEMAFDPPVPGARFDTPTSEQRSLEAMRQTPSTFGHPDDPGVSPEPQSMSLASIDSEASWLSGRLSKKRKSSGILQSSPYSQRPRQTSESDHDRFQEQDNLNENMSITDDDYLSRFTQPAGERSGWNRKSTGEARPSSDGEEEVHWGSVGGHQPMVVQTHAAERMKSREGLLKSFGEEGESDLQTVSPASDSDGNGAEDVDDGLHRATSVNLGKGHARHISAGSARLLSLSSRSSVEAKRASLSRSPRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P000</accession>
    <name>A0AAE0P000_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_465899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P000"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="193" mass="20824" checksum="9A0F270F3E63FBCC" modified="2024-05-29" version="1">MAPAKAARNGHDDAKSETPNSKEKNGAGVHQSNGKLRRVASSTGTNLREMANAGAAAAASALMASAAGSGAAVVQEASNPGLQWPAFDREVLHAYRRSYGLNTPTAFTKDHHKWILTQPGSVGLYSPTIARSSEFRRQTKDQLTSTVRKHFNGLGVQENDIIVDFLHKVRSQGVLKRPKSRTRRAGNVLPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P021</accession>
    <name>A0AAE0P021_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_123589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P021"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17434" checksum="4348B80104C46CE6" modified="2024-05-29" version="1">MSSPQWRIAVGCDDAGVGYKNKIKADFAADPRVVSVVDVGADDKTAYPHIAAAAAKLVASGECDRALLICGTGLGVAIAANKIKGIRAVTAHDSFSVERAILSNNAQVLCMGERVVGIELARRLAKEWLGYVFDETSASAAKVKVIHEYEEGEGGLSGQPEEVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P070</accession>
    <name>A0AAE0P070_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_126486</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P070"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="65"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="164"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="305"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3390928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="396" mass="42961" checksum="465E2F10AF5D6493" modified="2024-05-29" version="1">MPQALMSHAPMPPVSPHQSREVADAPVGAQKPRGSAKETEPALCPTDEASVPRGQAQQQNKQSFDYVWRSGVAGGLAGCAAKTVVAPLDRVKILFQSHNPHFIKYAGSWVGVSEAMKDIYRQDGPLGLFRGHSATLLRIFPYAAIKFLAYEQIRAVIIHSKEQETPFRRLISGSLAGVTSVFFTYPLEVIRVRLAFETKKEGRSSLRSICKQIYGEHPYQKPLVAELPGASGAAATAAANALAPRSGLVNFYRGFSPTLLGMLPYAGMSFLTHDTLGDVLRLPQFAKWTTLPKPANAPPGKAAPLRSWAELFAGGVAGLVSQTASYPLEVIRRRMQVGGAVGDGHRLRIGETAKLIMRERGIRGFFVGLTIGYVKVVPMAAAAFYTYERLKMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0P9</accession>
    <name>A0AAE0P0P9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_133697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0P9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="245" mass="27894" checksum="6F29B13BF41F5CD9" modified="2024-05-29" version="1">MASKRGLCWPTTNTDPAFVFSKLGSRVSWLYNWSPHPTPSCSLQFVPMQWNHVNIEHLADCRKKAGADAILGFNEPERSDQANMPVELAAREWMRCIEPLRRAGVRCGSPGISSAPEGVAWLRGFLSAIRAQGGDIDFYNLHWYGETLGQFYDYLWSTHHQLGPDKPVWVTEFAPTNWSVENPLPKEHVEHFCRESCKYLDTLDWVERYAWFGAMRDPGTVGKWAAMLGPDGKLTELGRTYRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P403</accession>
    <name>A0AAE0P403_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AtrD, ABC-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_554284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="71"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="775"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="716"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3392792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1464" mass="162765" checksum="631511C4C6CE566F" modified="2024-05-29" version="1">MEGPVQDEQLPVKSAESSTRSSPAFRQWLQGKDPEQHLRLGVSFRHLHAYGFMSSERYQETFTSYGLTIPRLVANLLSARNNAPQRVQILHDFDGLINRGEMLLVLGRPGSGCSTFLKTLSGDAHGFHIAKTSEINYEGISYDQMRRTFKGESIYLAELDVHFPELTLGQTLSFAASTREKGADRNAISSKVGRNVASLFSLDGAIDTKVGDAMIRGLSGGEKKRTSLAEAFISGAPFQCWDNSTRGLDSSTALAFIELLRGATDALQSTVVMSIYQASESMYKNFDKVTLLYEGRQIYFGPIDAAAAYFTNLGFVRPSRATTPDFLTSLTNPVERIIQPGFEDKVPRSPDEFASIWKKSAELKALLEEISAFNSAHPLQGKDLGEDSEKVKLRASTYTIPIPQQLSLSMQRAVNRIRNNPAPMVSAIIANAILGLLIGSVYYNLPHTAESMDTRSVLLFFALMVLAFAPAFEVITMWAQRPIVEKHHRYAMYHPFIESVASMISDLPNKFAISVMFSLTVYFMANLRRSVGAYFVFYLFSVTIYIVNSCYFRMVGSLSKTLDQTMPPSAIMVSVLITYTGFIIPADYMVPWLGWLRWINPVAYIFESWMINEFDGRLYPCLTTIPNGPAYSEVGMKGKICTTIGAQPGKQEIQGADYLFEKYGYVPNHLWRNFGILIAMGAFFCICHLLAAEYIPAERSKGEILLFRKQNISKTKRRTDKDVDGNETGGSTIFAQDINQSEDSDTDGKKDKTHTTGTEKRGDDVDGIQRQTAVFHWNDLCYDIKAGGNTKKILNCVDGWVKPGTLTALMGVTGAGKTSLLDVLACRATVGVITGDVHIDGRLRDAGFQRRIGYVQQEDIHLPTATVREALNFSAIIRQGGERSTEEKLAYVDTVLKMLDMTPYADAVVGIPGEGLNVEQRKRLTIAVEMVARPELLLFLDEPTSGLDSQTAWSICTLLRKLADNGQAILCTIHQPSSQIFQSFDRLLLLGRGGETMYFGEIGKEASALIGYFETHGAPKCPPDANPAEWVLDVTKLPPGISSAGSDSEASSQEKSEEKSEEESGEKSDSSAVVATDTNAPGNDIHHAWFEKWKTSHQRQEVLAHLEELKNAKKSTDSAPTEVGKHVVKDEYAATWFQQLRAVTYRLFQEFWRDPIFLWSKLGVCVGLALLNGLSFLNTRLTLQGLTGLLFSVFSLCQIFGTLDQQLIARFCSGRALFEARERRSKSYSWTVFISANIIVEIFWQTIAAVLVFAVWYYPTGLWRHTTEDQNTRGFLVFFIVWNFMVWLTTFSQAMAAGIELPDVAIQIATLLFWLSMLFCGVVIFPSALPRFWIFMYRLSPLTYFIDAIVLAGFVNTHIECSATELRRIEPILTPLIQTCGEYLAPYIAASGGYVANPLATTICELCPIADTNPVLALFGMEPVEIGTAWRNAGIMMGYSVFNIMATFGIYWLARVPRKSSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P480</accession>
    <name>A0AAE0P480_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_498510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P480"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="7">
        <location>
            <begin position="547"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="8">
        <location>
            <begin position="927"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3393198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119213" checksum="64CD7D55040F6F3F" modified="2024-05-29" version="1">MKQRFSSLDVKVVAHELSEALVSLRLANIYDLNSKILLLKFAKPDNRQQVLIESGFRCHLTDFARAAAPAPSNFVSRLRKFIKTRRVTKVSQIGTDRIIEFQFSDGAYCLYLEFFASGNIILTDSELKILTLLRIVPEGESQEPQKVGSTYNLENRQNYAGVPPLTKDRLRTALSTAAERAIAKKGNKKKGSDELRRGLATTITELPPALVEHVFRLTNFDPTKKLSEILDNETLLDELFRTLQQARSILDEFTNLPTSKGYIIAKPYPHAAETTADGEAIKADKTKGLLYEDFQPFSPKQFEDDPTCQILAFDGYNKTVDEFFSSLEGQRLESKLHEREATAKRKLEAARQDQAKRLEGLQEIQMLNLRKAAAIEANVERVQEAMDAINGLLRQGMDWEDVNKLVEREQKQHNPVAEIIKLPMRLSQGIITLLVGEEEEEDAEADVKYDFDYESEEETAEDTKIDKAKSVDKRLEVDIDLKITPWNNAREYYEQKRTAAGKEKKTIHQSAMALKNTEQKIAEDLRKGLKQEKPVLQPIRKPMWFEKFTWFISSDGYLVLGGRDAQQNEILYKRYLRKGDVYVHADMHGASSVVIKNNPKTPDAPIPPSTLAQAGNLSVCCSNAWDSKAGMGAWWVNADQVSKTAPAGEYLQVGSFMVRGKRNALPPALLMLGFGLLFKISEQSKAKHVKHRLYDTANTTGAPSESAASELEGRDLTSKSEERPADEAEASEESDDEDHEDDDNRANPLQSKALCQKDIRNSESPKVPELPSDELAQLQVTEEAPQATEEEKKAEDSDDEEYMKEDNDYVPPSTLAPSRSGTPSTSQPTKTPLKRGQKNKAKRIAAKYKDQDEDDRALMETLLGVTAARQKAEAEATAKAQREAEAAAQRERRLQQQERSKKQIAEHEEIRRMMLEEGVEMLEESEAMEMTSFDSLVGTPLPGDEILEIIPVCAPWNALAKMKYKAKLQPGNTKKGKAVKEIVERWRVGASKKNVIDESAADPEKMWPREVELIKGLKVEEAYNCVPVGKVTVMMSGGTGGVGGSLSSKGGGGPGKGKGGHRGQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P496</accession>
    <name>A0AAE0P496_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_4154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P496"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3392942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="33441" checksum="4F45C4B20D1557E8" modified="2024-05-29" version="1">MMEYAQYQQQPPSAHSQPHIQTGYPSSAGGNSITSPSNQHLPQTSPILPSQQHQPSPTQSHPMYQTQYGVPHYGMPQIQAAAMAATAAASGSSYSYMPPDPNLQQQSPRMSAKKDPRGGPRSPQQMNSQRRLSQVASPGVPNPQAMLNHAGPRSAVQPPMTAAQQMPPPPSPELTSGAVEESPLYVNAKQFHRILKRRVARQRLEEALRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTAEEVAAQERDKGGSGQENKDPEPILTKTASGATKRKSDAHSNAPIKKAKRVIESPEEDDEDDAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4J1</accession>
    <name>A0AAE0P4J1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_443393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="49"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="332" mass="37161" checksum="26CB2F97D5CEBF61" modified="2024-05-29" version="1">MPRERRREDEEMEQRPVSPEEAPDSDGDDRMEGIDSAESSESSQMIKKLVRYALACEYSRTPIRRDGIKEKVLGIHGREFKKVFSGAQKQLRGTFGMEMVELPTRDRNLLTADQKRKAAKSQNQKEATSNQYVLISILPEKYRVPGIITPSKVQSADGEASYIGLYTTIISIITLSGGELSDPRLRRHLSRFNAGENMPSLNPHNENAPNEKTELMLNRMVKHGYIVKVVEKSQGDDDSITWHVGPRGKMEVTNESIASFIRTVYGSSNDELEKKLQMSLKVKDRKTNAPAGIGEEEGPEEEASEPGPSTRRKSRGALPPKEAAESEEDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4L3</accession>
    <name>A0AAE0P4L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_386136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4L3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="155" mass="16199" checksum="B7B0A97FAD9C4533" modified="2024-05-29" version="1">MGSLPSVRGAAQQAAQAAYKKALEVASAADARLIFLSAIDTGSRRLVQLHLDNGVDANQQTPEGRSALHPAAAGGHEAVVQLLLTCQGVEVNPRDQHGRTPLSWAAGGGFIAVVELLLAHPGVEADAEDEVRRTPLSWAASRGFNVVAEILIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4S7</accession>
    <name>A0AAE0P4S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_505250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3393329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="557" mass="60739" checksum="1B05D8906F661453" modified="2024-05-29" version="1">MSSHGSHEASSSEKHAVSHDIEPAGQLHQDVGSKAVHGHQKTVHNAELFAAVNESNIHPWSKESIHMYFAIFIAFLCACANGYDGSLMTSILAMKHFQNVFQTGTTGTQVSVIFSLYTVGSMVGAPFAAVLSDRFGRKKGMFAGSIVIIVGMIIISTANHVPQFVVGRFVLGLGIAVMTVAAPAYAVEIAPPHWRGRCTGFYNCGWFGGAIPATIITFGCNNIDSDFSWRIPLILQAFTCVIVMSSVFFLPESPRFLMANGREEEAIAFLTKYHGNGNREAPLVVLQVEEMREGIKLDGIDKNWWDYRPFLLTHSGRWRMAQVLMISIFGQFSGNGLGYFNTVIFDNLGIKDVPTQLAYNILNQVISAIGALTAVAFTDRMPRRAVLVYGTLTCAAALAVNSGLSAALATQTEQGNVQPSYARGALASYFLFNVFFSFTYTPLQGAIPTEALETTTRAKGLAASGFIVSAVSFINQFAGPIALGNIGYKYIYVFVAWDIVEALLWFLFGVESQGRTLEQLEWVYQQPNPVKASLKVDKIIIQDDGRVIEKVEGAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4U5</accession>
    <name>A0AAE0P4U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_530581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="912"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="959"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="850"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111564" checksum="86309AB8010B9E17" modified="2024-05-29" version="1">MFVCSSPDFSASRSGRGRYSSRHAVASLALLALIATYTLFVPDPRIASNQKSSTSSSHGFGFSSRLATRGHLAQEADIDCRAVHLAPDQCAFILKNCGDDEAGLIHYLAFYYCDMANVKPVAFVILALWLGLLFTTIGVAASDFFSVNLSTIASVLGLSESLAGVTFLALGNGSPDVFSTFAAMGSNSGSMAVGELIGAAGFITAVVAGSMALVREFKVSKRTFVRDILFFIAAICFTMVFLADGELHLWECFTMIGFYISYVITVVGWHWFSMRRRRQRLRDAASRGNFYSVARAGDELEPYRDDIDDDDEAAPVGGRSRSAPEPADLSMLERADPRAPRIEVDGIGLASPPPDEDDEQREVHVAAEMTSSMRVSRPRWGRSNTTITPIRPSLVGVLEFRAVLSSLHRQRNMHLGPLPGRTYSEHPILERSSSSIEVGRNRSEVRGRPRTNTLPAQAWQPTRERALSYGNTPLNLENDGLHGLPRAGSQRPETRNSSTARTIDGRLAPPTTSRAAPDHTRQHSQSSMKSSQHLNIRIPSPGGGSSGQSSPSATSFPVFESPAILTPVHGSVQGPEETAFVFPTPSQRRRASTRIFEDHIEPPRPINWWPYRILPPPHILLATIFPTLQGWGEKSLWDKLISLISVPSIFVLVTTLPVVETDTQDDNTETDLADPPGLGHVGSISMPVSIESENGIEPETEWQEYRRRAHSVSSRSPLSLSPSLVDLPAQAGQASDEPDPMHYEQRPPLAVQVPPSSKLPTTGLELDRTTSSTEEPLGWNRWLVALQLITGPLFVVIIAWANMHEDMVQPGKTLVKLMLYALLFSMCLLATLLLTTTADKKPKYHHLLCYLGFVISVAWISTIAGEVVGVLKAFGVILGISEAILGLTIFAVGNSLGDLVADITVARLGYPVMALAACFGGPMLNILLGVGIGGAWMGISSANKKHKKHPDKPIHYKPYHIQVGGTLMISALTVLLTLVVLLIVVPSNKWVMSRKIGWGLIAIWSVSTALNLVVEITGTWAEVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5F2</accession>
    <name>A0AAE0P5F2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_458821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5F2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="115" mass="12903" checksum="CD179B5FD3026592" modified="2024-05-29" version="1">MIVSRNHDRWHSPCHSAVVLIIWPCLASERATMDHLVVAYPQHALHGKPALWTDSLFFGLLSRAVLKRVPQSETQSFAIQLPTARLNRLSVAFAFTLVCRGRPTRFAPVDSVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5J4</accession>
    <name>A0AAE0P5J4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_443911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5J4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000009">
        <property type="entry name" value="CTS2p putative chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="360" mass="38829" checksum="8654DA49583CB1AE" modified="2024-05-29" version="1">MSGSPSTRKARIANAANVMYTNAVYWPNHRFYNGDTPGSLNYGCINRVYYAFANVMADGGVFLSDEWADATAPCDGVQGALGSLMHLKQRYPHLQVVLSIGGGNSAETFPIVASNTLLRDNFARSARGLVEASGLDGIDTPVVWEYPCSPQQGADFLALLAAIRLHLHEDHYLLTAALPAAKQVLQNIDLRRASEYIDAINLMAYDFFGSWTHRSGHHAQLYAMNKDEPSGSSGVQHIMAAGVPAKKILLGIPLFGRSFLHVSGPGHKFRGAGGEEGSFEYSNLPRRGTKEQVDKRAVAAQCVGGDGGFVTYDNPDTVKIKAAFCKQKGLGGLCYWSAPSDAKDTKRSLITAGFRALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6C5</accession>
    <name>A0AAE0P6C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_38087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6C5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="167" mass="17416" checksum="854375678E53F0FC" modified="2024-05-29" version="1">MGRGSTKIGVFKDGNSFRVNVPFAVPEGQFAGTGENDWGSLSCYARYKKNLYSASDGGLCSGIYDCDHTKPTTSPIDTSQSPPPTPRISTSPPSPSPTPSPSPTPASSLNSPQKPAPDPTPTPKSAPTSAPTTFTTSTRDETPNRSPNSPFSSSTTFPILDPPPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P748</accession>
    <name>A0AAE0P748_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_460419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P748"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="136"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="348" mass="38305" checksum="547FE14FED604A07" modified="2024-05-29" version="1">MRTPYAQPPSQSSQLVVQAPQRPPVSTSLAMSSPASPANNSFLEQTVSLMSSVAGYMRLPAIASTGFAAILTSLLYFKQKALIYPSHVPANARTDIPRPSQYNFRDYEELIIPTNDGEKLSAFYIRGSRRGPNSNVTVIMFHGNAGNIGHRLPIARMLISNTGCNVFMLEYRGYGISTGEPDESGLNIDAQTALDYLRDRAETQKHTLFVYGQSLGGAVAIKLVAKNQSRIAGLILENTFLSMRKLIPSIMPPAKYLALLCHQVWPSDTLIASIKVPILFLSGLQDEIVPPIHMKRLYDLSTAPVKIWKPFPGGDHNSSVIEEGYFETIANFMKRVTSGDIPSSREKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P784</accession>
    <name>A0AAE0P784_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_461439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P784"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="215"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="56698" checksum="BCD86876AE9BAA7D" modified="2024-05-29" version="1">MGVCCSKPLAVVYKMGALTIRNLTITPLELKAVERLEPAPPSFSSPPHGTPSGLAKITARLTGRGGGAAHYPLPIGQPHRGNGHAILPGAFPGDDESGVDLVEQQPPPAPPPAARKVHELNGVLIQPFSELSLPDDITPPDVSRSEQLRMTFSEPGSSDQYIADVPSSSPPRSIVMKSPSSDKEFTLIYIPSHAFLSIFSSTHLSSWMSELFPALPLSALSIPGTHNSPTRFVALPSVRCQAVSVGAQLDNGVRFLDVRVSCPSSSNSEWAAAGGAPDLALVHSAFPISLSGTKYFHDLLTEVYAFLADHPSETVLVSIKREGTGRGTDQQLSKHLASRYCVPAERWWTEPRIPTLGEARGRMVLVRRFHVDESLAGKGFGIDGSVWPDNCADGTCGSGMIRIQDYYDLGQAEEIAKKITFAQSGLEKAAQPDSTAAEASPGVPAPLYINFLSASNFFNASCWPEKIAAKLNPAIIEYLCMGHGAPGKGPGQLTIGDAATGIVVTDWVGNKGDWDLIRCIVGWNARLQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Q0</accession>
    <name>A0AAE0P7Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_533150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Q0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042015866" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="148" mass="15771" checksum="17A2075523702342" modified="2024-05-29" version="1">MRCALLGIFLGIFSVLVHFVDAWGPGGDLVDACAYNGSTFTDGYLLGAYCLNDQTAIFGYNYTIIDLNLCVGNDDGTLVGLENGSYSEGCSNCTTANRDQSLYLICACLDINGQQHSSSIDLNTVLYNVDGCAHCFGHAGNKSWTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8H7</accession>
    <name>A0AAE0P8H7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_518228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8H7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3395162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34898" checksum="7EC8B8E901BE166D" modified="2024-05-29" version="1">MPRAKNETMLALVWESKPFEMAVRDIEKPTVQMPEDGIPSSSAFRSPTRALVALPNDSSSDLEFLFLPDIFPTTWAGLNYAQFQSGYSVAVFDAGPVGLLCILSAFLRGASQIFAVDHVPERLHKAATLGAIPIDFTSPEGSPNEQILRRRPTGDKRYIDCVGEECLNAQLKPQQNFVINDAIHFCRGPIGRQHQAGISAAIPELWGKNLSIGSGNIGEVYFQELPRLFDLIKTKRARLDFIVSSEISIEDAPKAYERLDKKLETKVVIRFPRHRQPPEAKPEAKPAAAVEGAPPADVEKTNGSTGPKVSTATRVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV48</accession>
    <name>A0AAE0TV48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_494866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV48"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3380874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48203" checksum="6E7ED976AB6B1F07" modified="2024-05-29" version="1">MEGHGGEDVRALLRQQRAARRIEHPHAAYSDAGKLLCTVCHEYVKAESVWDGHIRGVGHRQRLQALQKQKQAAAATTSRTDGENTARNGGTAHKRKLNEDEDMNDVPGGGGGGGTPDEDLVRKKRSKPDMTLSTDTSAMLPMTPSSGTKTSPTNSGGSKPATPGGAGGRRQSVTPTLGVEMQIPSRPATPVALREGGIINNAHTHSANSSISSSASATTPKTAAPVGRSPLIPQDNTSDSLPPRKAGFAVATESILTTSTSSVPTTSTASAAAPPQQQEVDEDEWAAFEADLINGETKPTANGKQALSYLESDAAISAPVMTAVEVAAKSAEEEREKKRALVDVQIEDEREEATRALETEFEVMEELEARARKLRERREALRLQRGSFGGGGGGEGKPEESSSANVAAVVNSGKETDASVNVDLGKENAAAAGTANDEDDDEDDEDDDDWDGFRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVJ2</accession>
    <name>A0AAE0TVJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_415774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVJ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="553" mass="62715" checksum="7BDA655BF521E523" modified="2024-05-29" version="1" fragment="single">MMKFPEPVDIMSHFSAASVASLSERVSGSSLRLGVAAAVVLFGLYLYLVPNSITDSRRKKLPPGPRGWPLIGNLYDLADTEKVRTKVRDWHRRYGDVFYTKIGATDYIWLSSPKAVKDLMDKKSGIYSSRPYLPLAQDVASGKSRQLFMPYGPDWRNLRKHSHALLNLNAAKKYMPVQNFESKVVLQQLLDQPDEFYSINRRYSTSVIMLVAYGYRVPSFTDPIIAKIFSVLEHLSIMMAPGAFAVETFPALAVLPEFLVGNWYSWGKKAFAHDSAIYLELWESLKRNVDAGTARDCFCKDFYLGNPEKNGIDNLLAAYTCGGLIEAGSETTATTINNWMLAMTLFPEELDKARAEVDTVVGASRLPQWEDEKNLPFIRAMIKETLRWRPVNKFGMYHSSTEDDWYDGHFIPKDSVVVLNWWAIHNDPSRYPEPDTFKSSRYLDKDLSAAEYINSNDPYERDHFAYGAGRRTCPGVHVAEKSLFIAISRIVWGFNITKKRGADGTLIEPTTRMMPGFLSVPEPFKCDITCRSPEREKIIRATFAEAEAEGLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVX9</accession>
    <name>A0AAE0TVX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adipose-regulatory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_209333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="44976" checksum="99804BD761487C37" modified="2024-05-29" version="1">MEELRDGVRELKSSLSDIYNALTSKTAQKSLLYTILFTSASAVLYGFAAVSYLVFYHNYLPDQITTVPVYLQYGYGVNPYGVATIRNIKDVQAYDISVSLTLPRSPPNLERGNFMVALQLLGNPSPSSSSFRAPPPPPPVPDAAENSQAKMSPDLLRTALLADRPVLYFAARPALMPYADPLVSLASRVVFLVYHVLFPHDAESTTLVVDVAERLAFSKGGPVPTTLLVELQAGQDLQVYKAQVTLTAQLAGLRYFMYKYWVTAFLLFTALFWVCEVVFMVLSFTAIASIFGGGDSQGKVPGKSGAGGRADGEGLDLMSDTERTFPTSSKQQPLKYESQMGIVKSESDEATEVTAADLPPVGRGAEADDEDDYKEEAKYDDEADFRDSGIGTSYSDHTSQSAPRRRNSRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC8</accession>
    <name>A0AAE0TZC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_494356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3385238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="517" mass="57597" checksum="120A282B0A2B835D" modified="2024-05-29" version="1">MSGIQTIAKLASEKLPLVLSTVGAFLVVVILQYLLKGNPIAKIPIVGQHLGSDEKRRQAFLMRARDLYVEGYTNFKNGVFRVITAQESNVIVVSPSFLPELKSLPDDVLSFDGAISETMHVDYTHLQIGNKAVPHMIKTSLTPALVRLNPTISEEVKEWFGRELPPCDNWTSVNINHKLLRIVGAVSGRIFVGADIARSEEYLDMAINYTVDLMKARHAVDGMKPWLRPFKANSIPEVQQLKARLKSAEAIMRPIVESRQREAAEGNTEKPDDMLQWLMDVQGSTKFASNLSTERLAADQLGLTFAAIHTTTLTSTNAFYNLAADPSLADMLRTEIRTVLAEHNGILTSQALQSMKKVDSFLKETMRFDPVAANSFQRKVLRPFTLSNGQAFPAGVILEVPAHAVSRDPEVFPDPDRFDPLRFYHLRQQAREAGHVEAAAQHQFVSLSPSVLTFGYGRHACPGRFFAANEIKMILANALLMYEIRLVEGVKERYPNILFGSGSMPDPTKELLFKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U089</accession>
    <name>A0AAE0U089_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_473759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U089"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="15790" checksum="4986F186BBE9C5BE" modified="2024-05-29" version="1">MDPPTQAAASSLPPEAIEFATRMYNAARKGDLDVFKQALPAGLPANMTNEKGDTLVMLAAYHGHADLVKLLLEHGGDPNRVNDRGQSPLAGAVFKLEDSVIEALLEGGADPDHGAPSAMDCIAMFNQEKWKAKFEAAPGRGKAGPPAASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0R7</accession>
    <name>A0AAE0U0R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_468097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000084">
        <property type="entry name" value="Heat shock protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="807"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="930"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111099" checksum="E295EC01180CDC95" modified="2024-05-29" version="1">MARLTLSPLSIFFSAIFLFSTHVFAASAVLGVDLGTEYIKAALVKPGIPLEIVLTKDSRRKEISAVTFKPSPNGPKKGEYPERAYGSDAMALAPRYPGDNYPNIKTLLGLPVDSEQVKEYAARHPALQLEASKLRGTAAFKSAGAFTPEEDAWMVEELLAMELQSIRSNAEALAGLGTSVRSVVLTVPPFFTIEEKRAVELAADLAGFKVLSLISDGLAVGLNYATSRQFPNINEGGKPEHHMIFDMGAGSTKATVLKFQSRTVKDIGKFNKTIQEVQVLGSGWDRTLGGDALNYLIVDDMVAKFVDSPKAKKATVAAESLKAHGRAIAKLTKEAERLRHVLSANQVTQGSFEGLYEDIDFKYKITRAEFEELAESHAARVGAAIQGALDAASLQIKDLDSVVLHGGASRTPFVQKELEKVLGDADKIRTNVNSDEAAVFGAGFRAAEISPSFRVKEIRVSEGASYPAGIRWKTDEGKSKHQRLWTAASHLGAPAKDVTFSNKDDFSVNFYQLTPGAVEAETKVFATKNLTDTVTELVEKFKCEKSDVRFKVTVRLATENGEPDVVKATAECEAEELEKAGIVDGVKNLFGFGKKEQQPLKDEEGTVEEVDASSSTTSETKSSSATSSASSSSASASESADAKAAAKKKQLFVIPIQYTVEKAGVPQLPKADLTALKDRLKAFEASDRSRRQREEALNQLEGYTYKVNDIIENEDFIAASTAEERATLEKKNSEASEWLYGEGADASREELKKRLKELQDIVVPVQNRIEEAAKRPELVKGLKDALASTNEFVFDLKKKIAEHEEFESSRIASSASSTSTSTDTSTVTVAPSAADFDGLEDESATTTTKAVDVEDLKDRGPVPPLYTLEDLKESEDLYVSISAWLEEKVAAQDKLGATDDPVLLSKDLTERREKLDKAGVDLAMKGVRNFEKKKKAKETKSKKAKVSKSKASGKAAPTIKLKPGEDGKMPSFTEEEINEMLRKYREENPDAGTEVPPPKAKDEPAQKKTEEEPPLKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U125</accession>
    <name>A0AAE0U125_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_430817</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U125"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="668"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3386992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117233" checksum="3E6553E2AA590159" modified="2024-05-29" version="1">MLRSSIRALNGAAASSASSSARCFSTVSASARASLKIASSRRPLAIAGQKRFESATSNPPNPNDNFLSGNTANYVDEMYLQWKQDPSSVHISWQVYFRNVESGDMPISQAFTPPPSLVPGSTVVPGLAGGAGVGIGEGSDVTNHLKVQLLVRAYQARGHNRAKIDPLGIRNSSKGFGNIQPKELSLDYYQFTEKDLDAEYTLGPGILPRFKKDGREKMTLREIVAACEKIYCGSYGVEFIHIPDREKCDWLRERLEVPQPFKYSIDEKRRILDRLIWSSSFESFSSTKYPNDKRFGLEGCETLVPGMKALIDRSVDYGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGSLGAEDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKVRAIQHYNNDEQTHRSAMAVLLHGDAAFAAQGVVYECLGFHSLPAFSTGGTVHLVVNNQIGFTTDPRFARSTAYCTDIAKAIDAPVFHVNADDVEAVNFVCQLAADWRAEFKQDVIIDLVCYRKHGHNETDQPSFTQPLMYKRINAHEPQINIYVDQLLKEGTFTKEDVEEHKQWVWGMLEESFAKSKDYQPTSKEWTTSAWNGFKSPKELATEVLPHNPTGVDKSTLDHIGEVIGTAPEGFNLHRNLKRILSNRTKSVIEGKNIDWSTAEALAFGSLVTEGRHVRISGQDVERGTFSQRHSVFHDQETEDTYTPLQNVSKDQGKFVISNSSLSEFGALGFEYGYSLTDPNGFVMWEAQFGDFANNAQCIIDQFIASGEVKWMQRTGLVMSLPHGYDGQGPEHSSGRLERFLQLCNEDPRVFPSPEKLNRQHQDSNMQIAYMTTPANLFHILRRQMNRQFRKPLVIFFSKSLLRHPICRSDIEEFTGDSQFKWIITDPAHEIGAIKAPEEIDRVILCTGQVYAALYKYRADNNIDNVALTRIEQLNPFPWEQLRDNLDSYPNAKTVVWAQEEPLNAGAWSFVQPRIETLLNNTQHHDRKHVMYAGRNPSASVATGLKSSHTREEQELLKRAFDVKQDKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U173</accession>
    <name>A0AAE0U173_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_149162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U173"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3387096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="403" mass="43826" checksum="58430DD3782ABB1F" modified="2024-05-29" version="1">MPADLRTDHHHQNILQDGSASCSLLPIMPQNGSPRTTTTTTAATGIGRDSTTTTTTSSSSSSTTGTAAAATQHQTPGGGSGYGPVAHRLVKRYRVEVAASASSVLSTLSTFPLDSVKTRMQTYRYAGFMDCVRHTYQSEKLRGFFRGVTAPMASITLVRTVSFSIYQRSKYVYCDWVKKNFGVDVMAHVSAKGTYPTLWSVATFGAAGMTAGSCITVIACPFELTKLSAQVSVLMADKKNCPKPESHAIAASYQNKGTLKTMGNIIKHRGFRGLYTGFNLHLMRDTLGTGTYFMTYESSKQLLTTFTGDSSHSNPLAVLVAGGLCGIVSWALIYPVDSAKSIYQRNSLMYTKGQKVEPVKIQFFQRNMYRGLGVSMGRSCAVNAVFFSSFEFLKKRIKAMEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1Q1</accession>
    <name>A0AAE0U1Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_509167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81030" checksum="9F7FA5240D0AAF97" modified="2024-05-29" version="1">MASPASVTARASPGGSRIGRPPQWTISRSRKLARLYLYTTLSIEKIIKVMEDDVFKPRKNSAQKTIHKMLDNDPRYLRPESRVEMDVRISNLAKAPGRRRKRPDTSPPTIQRQREALNRAHREQDVVLSSIEVSSASGSSRMAEDTPSAGFESSATSGWTPTTPGADDLGHGQFSIPIRSYDTERPQTSASSGTSVSMIRDLQRRVSNCSTNYAQQISVLLKEFTIASASDDDMPFEHRSSIDLSEPPGLADSPDIQALEAFEAFPEPGFALPGDFLSAHSRNCADFPGQEHGSGRCWCAIAAATSRDEGSWLHPTGELRDTARRVLGNPSPANLNLRDCFGNTPLHLFAALEGYQEALFGILFNSSDVSATNNANQTFLHVLNLEWFSDIDSPAAPLKQLLAFLRQSAPDLVYETDVYGRNFFHRAHALIRDPNILASILSPYNPALSSRRDSFGFSPLSHTQLGGEGPFIPPRRPTPQQDDSIFSHGSPRPGPRDEGSFLAYHAHLVQVIQSSYNNPRVEDASNGRNGLHCLAEAIIHQQAMDEQRSVMTKAARPLKRKTNQSDPAPSSSSTAHDEGILTTRLRHLEGLLHSGVDVNDYDKAGNTVLMAFITHIADEDDDKSKTLLSILETILRAGARIEARNRCGETALLVAARLGRKVALTTLLEHGAGVHARDVHGRGVLEVLDQTCRGARDDTALYARVEACRVLLTGRRDWGVVQRPGVVEEWRTRGGVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U259</accession>
    <name>A0AAE0U259_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_448622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U259"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="493" mass="56261" checksum="20B9AA619005F80E" modified="2024-05-29" version="1">MTSANSFPPGTALIERLPIEMKLRICECLRPASSRETARIIPSLPGTGHSEYKVSQEDLLNLCLIWYEMESMEEALQKDEGMTQALFGPDMDRFPFIQFLREFHADSSSASADSICDNWARYSESDEYTTGSGESERIWARLLDLKIECFEQGQKATEMMIVAALCFAPNLKTLVFQPRTEGWRSSYDRHPTYHNLVASICALNQAKPDNAENVVNGSYPCPKLEALELYINNHFSTINGMDSLFQLGKLTSLMLALDHAYGWLEESDLGMSAEEKGEIFLRFDSMKNIRHLTVRSLLPEYPCQHGVLKEYLENAVNLRTIRVEQEDGAKPSTDRKYQRQFGPNLKLDDCFPKLSFLTSLKVPMNAIFGALSTRPGEFNDPQEAEYGSWEEWEQRHEYYETKWRKHYEEKLCLVMEHSDMAPISPIKSTHYEKDPKKRACDCRFNAASLFRALAVHCCPRLPSLQVLIAEPDFARSTNRGSSDELRGLGETFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3R3</accession>
    <name>A0AAE0U3R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_492417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="649" mass="69460" checksum="C0A27D66C29B57C8" modified="2024-05-29" version="1">MATDARCSGVYSAIKSLSVSLSQVTIPFTSRTEALAALLQITSRPEIKLLSERLAPRSDLPRFSTTPLAEKLHYAIDRRDNDAVLKLLEYEQVNPNILRSGSSLTPLHRAFFVDLLDTAVYLVLAGANLEARNKNGETAIIRAVRSGFPDDFILLLCEQGAATNAVDFAGRTALHYAAEMSPEDNTILALYGYGADMGLRDRDGRNSLLQAVGSLRITSTRQLLSCGVALEATTDHGKSALELAITQGSTDIVKLLCDGGAALDVHIRESTPLLVAITSFCTDIARVLVEAGANPDLPSKGGCFPLIMASALGYEEVVEMLLACKADIHASSPSGNTPLHMAVQKNHIGIVQRLIGAQVSLNRANNDGYTPLELAVVAGHDSVVQLLLDQGASPNSSSNGQSVLWRSLENVRACSSRGAAAGQECETSHGHTHIICLLIKAGADVTKQEGREGITPLHLAARLGLNEVLELMLPLAAKGVETRIWAGHTPLFFAAEGGHIKTVKLLIDKYGADVFARTTADEHLLWAAAPHYQLLRYFLEMKGGGRRKSSGTAIRSQLNRSRILGTSRPAFDVNHRSHTGATVLHISASAGSSESTKLLLRRGATEFLANAVFNSLADQMEGNTYCQGTPSGLARQKGHTKIAAMIEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U465</accession>
    <name>A0AAE0U465_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_538098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U465"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="522" mass="57221" checksum="80D76562330427FD" modified="2024-05-29" version="1">MTVLLAKHIYAPLTLLSIFGSVKMVVIGSKSRFAHAKGRRANQHLSSGLPDRFPPPRDLPTSAAPLLPFLPVVAVAVSSGSSKPVSRSSAQAAPWPGVIGEGRPLPKPAAPPAAANPPASLVAAGRPVLLAAANPPVSLAVSNPPASLTVASPVQPTPSPTKTTPFPLDEQFGRFVLLADLLRKAGITGRYMKSCLFKYVRSLSKDQYLRLKAYLPNIMNLSKRQGKNSTVNEAEEWGTTLKGICSLGLGHNMEMEKVDAALANIKARIRKDPAYFDGKNGWLLWVALDFARKEVTNTETKKTIARSMFWLTEAENALFLSVMSWYFFFGFWNAYSHKSRPGDLFLGDKDEYKGTYMANDPKHRSEITAMEKVLVSVMSTVKDGALQSGSVEDLHALYGKHWNNQTPTAFVQPHSVSRGIFYVLHWQNDEFLHLLDEYNHAVEIHAKEKDLNAQLANLSMGPLPSGYLEGLRGQLSYSADPSIQQSYSKRLSYEQSYPAVGYSTQQSHSAGPSNQQGYCGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4E5</accession>
    <name>A0AAE0U4E5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_109444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4E5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF1">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="118"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="29804" checksum="FB94693745497D04" modified="2024-05-29" version="1">MANVSDPSHLSLPTMKGDTTRSEATESFYKSERPSSIPVASGRPGNATPPVMSRPPPSNPRPKSAGSHVHHRFLSPAEWARVAHGLGAIKEGETHSVVHPNCWYWPPKGLPDGLYRDVVTQRTKYLFSHHLLSVLCWFLMVGQIVLGAILTALGSLELRDGTPITILAAVNTIDAGLLALMHNSGLPDRYRLNKVEFCKVEDFLKELLDTGIVEATQGVDDVLSDCFAKYQTAKATVLANMPDHYTIPQTSAKEKPIICPDPPAHFISTHAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U514</accession>
    <name>A0AAE0U514_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_500126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="648"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1603" mass="176656" checksum="9167056CF132FACB" modified="2024-05-29" version="1">MSRDAHLSTAMDPESLDAPVARRTGLMSSRMQYRSRPVSVAVDPVSLVISECIAITSAIQKNARSPHSSVSAILGGSPNLIQLVPPTPSSRRDRKSSSGADPLADSPAGDLAANRWGLRGKKGKSMQDNPLISGFGRLRQELTGVKDIHKFDSLVLLYPFLQIIQAKGTAAPITILALRAIQKFLSYGFIAPTSPRFALAMQSLSAAITHCQFDISDSAQEEVVLLMILHLMEHMMSGPGGDILSDESVCDMMGRGLTICSRSRFSEVLRRTAEASMVRMCQIIFEDLKHLEVEAGVESEALDIQTSGDMDDIKMDPAANGTDVPVVQSIATAVPATVQSAAVGEPRPSSSSEKARSSVETPASADAGRSSTSSTAESSESLDVRPYSLPSVRELFRVLVSFLDPHDRRHPDQIRVMALRIIHVALEVAGPSIARHPALAAIAEDQLCSHLFQLVRSDNMAVLQEALIVASTLLSTCRGVLKLQQELYLSYLVACLHPSVEIPREPGIDPSLYSGIPQAPKLVKPPPSQASSGRSTPVPVKDRQKLGMEGGARKPDARQAMVENIGVLSRMPTFMVDLFVNYDCDEDRSDLCEDMVGLLSRNALPDSATWSTTSVPPLCLDSLLRFIQFIAERLDDTPATEGYPDPEVLREKRRRKKLIIKGTSKFNENPKGGLAYLQEKGVIANAGDPVCVAKFLKGTSRVNKKQLGEFLSKKGNEPVLEAFMDQMNFNGKRVDEALRVLLETFRLPGESPLIERIVDCFAKTYCSSDIPEGVADKDAAYVLTYAIIMLNTDQHNPNLKSQARMTITDFARNLRGVNNGQDFPPEYLQEIYDAIKTNEIILPEEHDNRHAFDYAWKELLLKSESAGPLILCDTNIYDADMFATSWNAIVSCLFFVFMSATDDTVYARVITGFDECARIATKYSNSEALDEIIYRLSYISTLSSETLSNTSLNTEVQVGENSVMVSELAVKFGRDVRPQLATLVLFRVVTGSEHVIRKSWKHIIRIWLNLFVNSLIPPFFSTEPDRISLPPIPLQNPSQVIDRGAKQNESGFFSAFTSYISSYAADDPPEPSDEELESTLCTVDCVNQCHMGDVFANVSNLPSKSLEALVDTLLDQIPDDSGSTVITVKTEGTTVPAVNGQKARQSNAIYDPTLVYILEFCTVLALRDESTVELLGKRVVEAIQAVLRDVSRYHTILIERATFYLFTLLQASYDFDYIRVPILLHTVSSFSKEVLTKTSGLVLRGIKLCIEKPCPLRNEIMTSPDFWVILHTLAAYPDSAPVVFEILESGVSGTQSAIMADNYEAVISLLNEFASMASVGAAAEQKPADRKQGRKAPRPVKQEKRSENAVVARGSKAIDNIYRLTARIPHLMKQSHLESNEAWSAYWLPIFQALTTQCTNPCREVRHLAFASLQRSLLSEELTSGDHEEWTAIFGEVLFPLILRLLKPEVFSSDRDGMSETRVQAASLLSKVFLQYLVKLSEWNGMLDLWLKIIEIMDRLMNSGQGDSLEEAVPENLKNVLLVMSDDGYLVPPSQNPEREELWNETWKRIDRFLPDLKNDLALGGPEPLAKESVEVPTVTAAAAAAAAPPAQVEEEGKGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U5D2</accession>
    <name>A0AAE0U5D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="11" type="ORF">B0H63DRAFT_131420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U5D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3391074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="35645" checksum="565F51A64F58853E" modified="2024-05-29" version="1">MDPTTDNISGTILALRESLCSEATPLAVRFRALFSLKHLARQSTDPAQSLAAIDAIAAAFVSPSALLKHELAYCLGQTGNHAAIPHLTAVLEDLQEDPMCRHEAAEALGALGDAESLGVLRRFRDRAGEEVVVTETCEIAIDRIEWENSEQRKQEKLRQSDFASVDPAPPMDKDGQGTVEELEKSLMDTKLPLFLRYRAMFALRDLASPPDLPTAVPAVLALAKGLADSSALFRHEIAFVFGQLSHPASIPALTASLSNLEEVSMVRHEAAEALGSLGDEEGVEETLKRFLNDKEAVVRESVVVALDMAEYEKSNEAEYALIPEVTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7G6</accession>
    <name>A0AAE0U7G6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_406376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7G6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="337"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="79458" checksum="528D674049C6D181" modified="2024-05-29" version="1">MAVVAAQNGTETSAVSGRVGQPPPRKLSKEELVKTHKGYLKKQNLSPDAPRPVKQPVLSEAYPASTKSIRDVEIMPLSDLRVETHHRGKGIIVKVISMPFIGAGAVSIVEDEFGNVDKLAIYNQGDSSILSGVPEGCVVGVKEPYYKYNGAENDYMICVDHPSDVILLRFADPIIPESLQLGPLLKTSLEWRTAGDTAFIERDYPTAVFCYTEALETAEDDASEAPIYTKRAGTNLILGRYDTAKADALASLTGGSSDWRGYYNAGKAAYGLCEYKTSKEHFEKALQLNSKGSGIQKEYERSLARLREEEHGEYDFAAMAASLSPQNVHLDNGSFLGRTRVAESKHHGRGLFATQELKAGDIVFVEKATLMPNQYEPARASAALYAMMVRQLCENPSLAQSVLSLYPGKDTPYERTGAEGTIVDGVPVVDVFLVEGIRTKNCFSAPLSTLEDTKPTTPAGRLAKGLWTHAAHMNHSCVPNTMRSFLGDILISRATRDVAEGEEVFQQYVPVSSRVDERNLQYKHSWGFECRCTLCEGERRSPAAMLEKRKEVLIAVEKACDKRLPGRHGESEKFVPDAAIRSVDRLAKQLEDLHEPEVYDKLPRLMLIYPCNWLVGAHRGRKNHAKVVKYGLKVLRNFGFRVPAGDDDKEVAAWDPRNIFSKSGNISLMTIHVVVALRRLAEAYQALGQQETSKRCTEAADFGYQMVTGFKNDSSVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7K0</accession>
    <name>A0AAE0U7K0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_27269</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7K0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="40093" checksum="DAC9E76E81A2472E" modified="2024-05-29" version="1">MSLPVAVATGSLSGTSAKASKANIGVFTNPAHDLWISDAAPTLESVQKGEELKEGQVTIAIRSTGICGSDVHFWKHGCIGPMIVCGDHVLGHESAGEVIAAHPSVTSLAVGDRVAIEPQVICNACEPCFTGRYNGCESVDFLSTPPVAGLLRRYVNHPAVWCHKIGHMSYENGAMLEPLSVSLAGLQRAQVRLGDPVLVCGAGPIGLITMICLKAAGACPLVITDIDEGRLKFAKEVCPEVITHKVERLSAEDSAKAIIASFGGIEPSIAIECTGVESSIAAAIWAVKFGGKVFIIGVGKNEIQIPFMRASVREVDLQFQYRYSNTWPRAIRLVENGVVDLSKLVTHRFQLEDALQAFETAADPKTGAIKVQIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8V8</accession>
    <name>A0AAE0U8V8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_387114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="742"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1305" mass="145681" checksum="85738E17A7048530" modified="2024-05-29" version="1">MEGRTYPLGAASYNASPPLPERPTQPTPLASVAEVPLAHGMEGSNHRIAFRPITGLQSTVRAVTPELPEAGVPQMPRSFSPASPQSSPRSIPGVGNASQGTMPVRHQGAVFNEIFAGSLANTSSSPPPHPPSFRPRTHTMDGAFRQQLAPSLETRHRMGSFSSGSLPIAEDPRTPSLQPPFDAYRSPDVQLSASAPGSKDRKSSSVRSRLTKRPSSRPTSPLSSAPPSVDSLPLPIPTSDANKVLLLMKNLCGRMRGQVEYQRDKGGPWHAGVAYIEEEKGSLMFDSGENGPFHTALVSDLRACRVVPMGRPDRDRQCLEIVSPHLNLALFLRPVVAEELDLWLAALLCWQQLRPPGARPANSRSVSGVAPPARVEIKRRASSSGLREAAIIKIGKVMLWDKGFATSPRAIVKRPSTRDLRSSQTCWRKVSCILQDNGEFKLMTENDVSVLSVIELSQLARSAIQQLDRSVLDEDYCIAIFPIYSSTSTQLSIFRPVYISLESRVLFEVWFVLLRAFTIPDIYRFDPDNGGQVYEVADLDAEPIGEVFRVEKTISIRVTEAKVRSRTLTSDGASADRHGRASEHELVAGNYLAEVILDGEIRARTTTKMDTKNPFWREDCEFMDLPSSLPYLSVLLKKIDGNHESFSHQLQATLGLLKAGNLTEVLCGAVDIPLRQMERGKDHEQWLPIYDDKQQSIGSMFVKIHHEELVVLLSKNYQSLSELLHRFSSGLTAQITEALPGSLRRVAEIFLNIFQVSGSATEWLMNMVEDEIDGIGNQAPMKKPRFTERLKSNDSIDSTSDREQIVRDMGRSLQGEANLLFRGNSLLTQALEFQMRRQGREYLQETLADKILEISDMNPNCEVDPGKLQPGEDIQQHWSQLILLTTEVWECIASSASNLPPELRHVLKYIRAVAEDRYGDFLRTVAYTSVSGFLFLRFICPAILNPKLFGLLRDHPRPRAQRTLTLIAKGLQALANLSTIGKKETWMEPMNRFLTSQRQPVKDFLDAVCAIPVERTKVTLPASYSTPITILGRLSPMAREGFPSLPYLIDHARNFAALVRLWVDAHPAGKPHAYEGDLLEFHNQCVLIHQRAIDCYARIESLRIADSASQSTEDNQSLSDAMDRLNMLNMSTSSYGNNSAVWMDNEGRPPGSSGSEIDEPALAGRDARHGRESSSLRHVSKSGEPQSNGGTVRGLRNGIHPRKFLSGFIRKTRTASPDATTARERERGRELERDKSSEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKDRHHRDRNKGHGPSEQWHGDATTRHQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U9A9</accession>
    <name>A0AAE0U9A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U9A9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="344" mass="38148" checksum="656770481B7A6C65" modified="2024-05-29" version="1">MPDILPESLPTSAISEKCSTASFQSNSKSETVHEIRPIPSPQDVQALRSGSEENNPLRFRRYQTLHVFKCFRTPTRGGKISCSSKSSLPYYILRSIFAIGVAIFLMLCGAFGTSALLICTAISDMAARLLVAVERPAGYLENTEAAIPTGCMLAAAHQNATEWYLFIGDRAIVDSLLNKTMFWIPDSNTSRLVGYWLQLAHFIQIAAMTFAAGQKGWDGVSLMVLVAVNRLFERFSNGNSKLAERWLAHEGVGVDLKSFEFSGRTLMLGAVQLFSGSQTTSWMDDIVTPHPRRDAWLRYLVRGEEPDHNAWSPGDLARIEMSAKLSIEAARVLRTYLMGTLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JVZ0</accession>
    <name>A0AAE0JVZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein, cytoplasmic and nuclear</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Polyadenylate tail-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_536888</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000018">
        <property type="protein sequence ID" value="KAK3365451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JVZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="219"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="323"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3365451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="371" mass="40587" checksum="76024DDFE2A99D94" modified="2024-05-29" version="1" fragment="single">MAAPVAPSAVDQLAADLGNTSLNGGEKSAPAINTNVASEYQGDELDTAGPTPSSAAPHPQASASLYVGELDPSVTEAMLFELFSQIGSVASIRVCRDAVTRRSLGPPLPYHVVAARSCLLRKTGQGNVFIKNLDVAIDNKALHDTFAAFGNILSCKVAQDETGASKGYGFVHYETDEAASQAIKHVNGMLLNEKKVYVGHHIPKKDRQSKFEEMKANFTNIYVKNIAPDVTDDEFRELFESYGDVTSSSLARDNETGKSRGFGFVNFTSHEIAAKAVDELNNKPFHGQDLYVGRAQKKHEREEELRRSYEAARLEKANKYQGVNLYIKNLDDDVDDDKLRQMFSEFGPITSSKVMRDALTDGAEDEAREGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXW8</accession>
    <name>A0AAE0JXW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_405377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXW8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3366441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="23654" checksum="7E74522B6759FF93" modified="2024-05-29" version="1" fragment="single">PQLDFQAVFPKEAFNSSLFPNGGNIRGSLKAAFLPEEGLVRFYLNVSNVPTVGGAFSYHIHVNPVPSDGNCTKTLGHLDPFSEGEAVPCNTAIPEKCQVGDLSGKHGPISVAPIFQATYDDRFIFTSQDIGAYFRNRSIVIHQNNKARITCANLFETDESDTQSEYPQIPSLPTPPLVTVLPPTSRSSGSLTLGKSIFSSVIEGQTSTVAIIVAIIMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZV8</accession>
    <name>A0AAE0JZV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_82569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZV8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3367488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="271" mass="29353" checksum="08BC368A0677B310" modified="2024-05-29" version="1">MADRGTSAPRGGGFAARGDRGGDRGRGGDRGRGRGGRRGGRRGGKSEEKEWQPVTKLGRLVKAGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVIIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVIPVRRGYWGANLGLPHSLPTKESGKCGSVTVRLIPAPRGTNIVASPAVKRLLQLAGVEDAYTSSSGSTKTLENTLKATFAAVSNTYGFLTPDLWKETKLIRSPLEEFADSLRDGKRYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZX8</accession>
    <name>A0AAE0JZX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_489222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZX8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3367461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="79984" checksum="EB28F2324AA60511" modified="2024-05-29" version="1">MSWRDAAGDSSRRCRSYLPPLNFITLHYAYFISVCLVASIIFWGSSDPAKSVSYTDSLFLVVSAMTEAGLNTVNLSQITTWQQTMLFMLIVFGSSIWVSIWTVLARKRAFEKRFHDIVRADRLRRANRAGSAISLSTLQRFVSFRKAQTTPRMPSSGAGNLESGLALSLFRPASSPNIEMPIASSADLDSVVAAHEASTDTPPAHIAFADNPHPNSGGQESATATSSAAQYRHQESRPMRRNLAISRAPASSDKGKFSGRHFLSYRTAGRNSQFHNLSSEEREHLGGCEYRALKVLSVIVPVYFFAFQILGCIALGAWMHNNQPGPPLENGINPWWLGVFNGASAFNNSGMSLLDLNMIPFQTSHFVLIAMGLMILAGNTAYPIFLRLIIWTLLKLIAFTTTEDEFCEIKDTLRFIITYPRRVYTNLFPARPTWWLVFMLVLLNSVDWVSFELLNLGNPAIEGIPAGSRVLDGLFQALAVRSGGFYVVAIPSLYIGLQVLYVIMMYISVYPVVITMRHSNVYEERSLGIYAEDGAETDPEYGGQHPTPPPPTPQPSNIRPVASLRRAFRLSVHNFGIPNESRRPESRISFISQQIQGQLAHDLWWLVLATLVIVTIETSNFLADPINFSVFNVIFEVVSAYGCVGISVGVPNNTYSFSGAWHTASKLVLCAVMLRGRHRGLPVALDRAVRLPGEALHEEEEEDHRIRRSLTNRRVSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K167</accession>
    <name>A0AAE0K167_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_69732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K167"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="131"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="704" mass="77262" checksum="32236ACB7DBC3B2A" modified="2024-05-29" version="1">MAHHEPFKALGPVEWETAVENNSDSLGNLLSTTFENAQVLVDSIPSTAAAAASSTLATPAAATSSSGRARSHTDSAVLGGGFDANSVIAGGAKHQTTAAQLRKEWKEIKIKDNPLNISVYKLSAKDGKGSWFSRRSVHHTARDNITFDKWRMALQREFAETLANCEPGTGKEPGTGNIRGIGAERRVERREVEGHGVAELFQVSARFPGPTTPRDFITLLLMPDTSSEPKGKGRKPRQFMLVSKPCEHPDCPPRSGFIRGQYESVEVIREIPVDRPLRRTRSSIDLSREEMVKSTHKSGADSSSVAKEAMLRAARMGVTDLEPFMAAHSAGEEEDEQEMAIEWLMVTRSDPGGSVPRFMVEKGTPGGIVNDASRFIKWLESRSIDDIAAGGHRDADGKAEKHHKEEKASLSVEKPGQAAVPPHHPQEHQRTSSEDSVPLPSGFYGMIASALEAAGSVVVSRMANLTGSAQVTEDEDEIDEDGSDTQSELSYASAEEGESGILDKANNSSTPDLSIRSTRSAVSEASQAVSSTLPATASSAQQQHEKELRKLEEKRRKAQEKIARAQTRQAAKNLSKNNKNGHRHNDDSTPAISSKDAEKEALALARLREKHERELAKQEERYQRDLQRLAEKRLAEEKKAQERKRKAAEREERQNLQRELERTRAERDVALKQIEILRETVGELQAQNTMLVARLGKEGALEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1E7</accession>
    <name>A0AAE0K1E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_529560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1E7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase C-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3367852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="117" mass="12604" checksum="3DEEB7A01554B457" modified="2024-05-29" version="1">MPLTAATARPGHGNRPSHQCPDHTLEEPGRPRAPRRENAAAQRSAPRVLASMEPADLAKFLTGNLHWRVTSAGPLIDPALIPSLKVSLAVGKADHFADITKLSRFYDYKGAFEPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2A8</accession>
    <name>A0AAE0K2A8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthase side</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_441593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="528"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1550"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2081" mass="227066" checksum="C29496E7BAC3E5C2" modified="2024-05-29" version="1">MAGRRISLTFKTSASEAKSPYSESTQTVTGLFHQQAKLNPRDTAIEVDNEGVTTYAQLDRQSSVVASSLPAGSVIAVCLDRSSQLLVSVLAILKAGSAYVILDPDAPTRRNTLIAEDVNAAAVLTSAAYVSRFPGAAIVVDTLLKQTPTTAKLPKPLPSIDPSSAAYIIYTSGSSGKPKGVVISHRAAAHGIGHFSLNAHQRWLFFYNPIFSAAQRTMLATLCKGGILCIATKEAMTTSLMSVVARMNVNAIGLTPSMLVTTTPGQIPACLRQITCVGEPVSQNLADAFADKVELRVSYGLSECAQLNFGRRLARGDNPALVGKPTDTTEAIILRPGTTEFVTSAGETGELCLIGPQLADGYLNRPVETALSFVSNPFGPGMMFRTGDLARLSPSSNGEFEILGRVDNQVKINGQRLEPEEVASVLAQHPAVAHAHVVAANVKGIKSLVAAVVLSQGQEWSTAVAEMRLATQNVLPAYMVPSYWIQYAELPLNRNGKVDRHAVRERVESASMEELLGRSRSAGNLQEMVEDPVEKIIQGVWADVLALDAASIGRSDAFFDLGGSSLQAIQMLNELRRRDVYLTLEAMFHDRELVQSLRSESGVVDAFPATDFQESLVGITLQGSADYTYQRVWDIRDLDPVRLRLALHVAFLKSQTLRTSFIHSDSGLVQTVRSDMEFPLQVLETALEQYRKEDLEKGFTLGEPFFRAAMLQGSILVVTMHHALFDYWSHSFLYDDVAMYYRGLQPAPRPGFQRFVAEMLKTDWSPSEIFWRENLETTAPSVLNFAPTPQTTSLGRSFGIDLNQVAASHGVTVGSILYTAWALVLAKQLGSNDVVYAAPLSGRETPLLDIDRLDGPTLTVVPLRFVFGTDQRLAEAIQTGHALTVDALKHSQYGLRKILRAASQKADLFDTMLNILPVQNKADNNSTGSVFKVYGDKPAWKTEYTTLEIEPSADGSVSARLSSTMEPERAGFILDQFVMVIQMMLHEPQRPVSAINLITETETNMLSRTADMPSNLPATMLTRYDEMVARYPHRIAVQWQTLESISYLDFDQRTNQLARYLVRNVGVRKGDFVCLMLEKSPMMIMAIWAVLKAGAAYVPLSSENPVDRNRFIVEEVGASIVLSEKGVEQAGELDAPVLLLSESLFAGLDKSPPGTDIDSQSIAYVIYTSGSTGRPKGVLIPHGAGAAAIDSMAAFEGRRRGCWRVLQFSNYIFDASMIDIFNTLTSGGTLCMAPQERLMSELADVMNEMMVTHSFFTPTVARLLSPKDVPNLRSLCVGGEALTEDIIKIWGRDCAIVQAYGPSETAIVVTMRDMEIDHRSNNIGKPLVTTQAFILERDGTGLVPYGAIGELCIAGPQLGAGYLNRPETTAQAFITVDTISGEPISLYRTGDLARWLPGGDLQYLGRKDHQVKVNGHRIELGEIERAIMVAGEESDLADCVAVVAAVEGKPQIAAYVLFHPSSSAASAQGSSSGIQDPEEFVDHVNEIRSKLTGLAHYMYPKIVLPVPALPLMPSGKTNRKLLVAWVEKLDAADISRYYFDFFGGGGTVVAAETKAERFVEEAFSAILKVSRDALGKTSNFLALGGDSISAITLASYVRKHGYTLSVSTILKYPLLQDMAQQVGIADEGTDSESGWTVVEFEPPQAVHDQIHSAGMSQDEVEYIYPCPPGQAEFLSQGAKDTQGWVLQAVRPFPSAHDLQAWAAVVVKLTETNDILRTTFTQLNGTWYGVVLKSSGIVLDILDVASETERQSAIDAIYASSFRFGAPFIRYAAIRLPSGETSILTKMDHALYDGTLLRIFAGHFKSLQQNNEPGAVEVLSPFRSFALHLHSLTREKAAALEYFTTSHAPSLVPQFPSIPSPSATHTVFSPGPASLTGVDTFSTSAGITTPILFQAAFQAWLSRQTGRRRVGLDYLYTGRNVALPSPQDINGCTANFVPLQASVCGTLKEYLNHTQDEFWATTEHGVVSLQEIFDANHISREKACNGCLFLFQPFEPSPPRKEGEKEEMKWVVMAGSQARMMQPYGLVVEVIKLPVPGQHKLKITYDPRAFSEDGAKRCGREIWEILEGMIEGGLEVDVEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2R1</accession>
    <name>A0AAE0K2R1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="197"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="640" mass="72771" checksum="65B89D0D2A8EA362" modified="2024-05-29" version="1">MEGNVDQLCFACQQIDLRALFRSGDFADHDDKLDSPTHTVETLRAQTHCPLCRLFLWVIDQTRDNDLTAVFSDLLPSDVVLLTPTSLPECPSQYGLRLEVWRDSEGVDWSRLSAPYMLLPVASGWVPSENIFPAMARQAGGTMFDWDYAKSWLEQCDNTHGYRCESLVREGGFVGIRFRVIDVDRECLILAPDNCSYTALSYVWGNVQQPLLKTTCLDGWHIPGAFRHIPLPRTIQDAMEVCRKLGLKYLWVDSLCIVQDLPDTVAGQVAHMDSIYSKAYLTIIAASGEDCQEGIPSVRARTPIQKSAWVSDLNIATVFLNGNRELINSKWNSRAWTLQEYVLSRRCMVLTERHVFFSCGEGLRQEDILGIRPEFARIDPSPAALPVIRRSLLSNKPDDIIMRDLYEQLTRAYALRFTTYQSDIINAFTGVTGALEPYLGRFLFGIPEDFFYFGLCWVFNASCRRRSLFPSWSWAGWDFTGNSASVNMFGYRYGLEDHHLGWVHTHNKYFNGGPASRVWRSGRFSMTINGAPNHHKALYGLLGQESRKEDLGLNDDQKAHLIAFVTYFALVDVARQPNLRPTVESSKHILFIIIVAAAPDVMILPVEKRGAVFERIGNPESMNEIEWFAMNPWVDWVYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K301</accession>
    <name>A0AAE0K301_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_489014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K301"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="23425" checksum="D85B487A519A17B4" modified="2024-05-29" version="1">MSVKTQEPVITRVSDLPTSEARWVALKKVEYVDQVGTARTWEVAVRKTRSAKAGVDAVAMGNIILHPSRPPATLLVIQYRPPLDAYTIEWPAGLVDAGEAAEEAAVREFKEETGYDCSVTSVSPIQAADPGMTNANMQLVMVEVQLKEEDGEEPPLQRLEDGEHIQRVIVPMSEFYDRLVEYAKQDRTIVAAKLFHFAAGIHFAKTNRYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K597</accession>
    <name>A0AAE0K597_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_367600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K597"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3369910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="67" mass="7595" checksum="C98C75529BC73C21" modified="2024-05-29" version="1" fragment="single">LNHYELLGVDKKATEQEIGRAFRQKSMDCHPDKFPNDAAKAAEMKALSQAKTMLLDPAQRETYDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5T8</accession>
    <name>A0AAE0K5T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_486401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5T8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="83" mass="9780" checksum="E718AE4587E7027E" modified="2024-05-29" version="1">MVQCVSCFWLPLLEELSQAKLGFLTAYSVSERSQAPQVSYWSYDSSWRKVHLHPQVRYHHLWRVWELPRSDQAGKVEMVLGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K884</accession>
    <name>A0AAE0K884_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_284670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K884"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3371973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="316" mass="34894" checksum="6B07260C89141824" modified="2024-05-29" version="1">MAVSINDRTAEFRHIVSAAKRRQAAKAGSQRLLNDAQKSAAGDDGRPRRSEFARKAADIGRGISGTMAKLEKLAQLAKKKTLFDDRPVEINELTFIIKQDLSSLNEEIRGLQALSRRLHPKPDQEGENNKNILLLLQGKLGDVGANFKDVLEIRTKNIQASRSRTEAFVSTVGQHAHVSLQQSASPLYGTPNRGTPSPGADLISLNPTGGDHQMQLQMMEEGQNTYIQQRGQAIEAIESTINELGSIFGQLASMVSEQSDMIQRIDANTEDVVDNVEGAQKELLKYWSRVSGNRWLIAKMFGVLMIFFLLWVLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8L0</accession>
    <name>A0AAE0K8L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_526989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="278" mass="31989" checksum="AB7A333BFCCC7007" modified="2024-05-29" version="1">MAYNTPFPSANLLYVSPIVRDTTPECGSPTTLAAFSPQGSDNGDGDGDPQQGHSFKPWSLVLILRPSRDVASGNSRSVWMARLEFDCNDLPKLMRDGLRWDSAMNVIRERGFWAPVSEPEYQSKYAVFRQWHLQEHTTKPETECRWVARAKVYAQKVYQLSDFKLWALDRVNIESAVAHNQDGQQVFHWCKRDPEWDINCIHDGADYFSCGVGKWWFWPMGGERDLYKQRLEEEERQKQQQSQTQPQLLAYSNFGIDNPLRRVRGGPSGHFGPLTAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8Y3</accession>
    <name>A0AAE0K8Y3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_292746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="238"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="426" mass="47581" checksum="E8C85120D3C61D79" modified="2024-05-29" version="1">MVDAHAPVGSPAAEPQHHEEEKTTHQGGDDGAAAAAAADDSDFLSEIDEDTFDDNFKPVDIDENVAKSLKAAKRKRTDTEAAKKPKEGRRPKKRSRTNDEVDPDDADEGGARRPRKARTEGERRTARKEVPPPEKESEEHLTPEERRARALDRAIDAAVKNPSKRRRKKDEIDLEEEIDEQIAALKVAMEKACVADNEAREKSEPAVHKLKLLPNVTALLNRTAIQDSVLDPETNFLQSVKYFLEPLNDGSLPAYSIQRDIFNALVNLPIGKDSLLSSGIGKVVLFYTRSKRPEVTVKRVAERLLGEWSRPILKRTDDYKKRHVETREFDFNAAKLAQRQEAAVSGSQLTLTQRPVGKTKYELEREKMLAPDPVHSNRARPAGLPASYTVAPRSTFDGTRGPDHRPIGSGGNEAFRKMTQKGKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9T4</accession>
    <name>A0AAE0K9T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="127" mass="14462" checksum="66B4058BC61B49C0" modified="2024-05-29" version="1">MGQIARPMTRPNIIIRAYQELVKGLEDEQALAQYMDDKVRRRRTSQMRAREQPQNTCCCCDANRMDVVVLEVSYSQQDGKDLQKLASDCILRSNGDVKAVIGVDINYGQESSTVSLWRPNHVEEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAK3</accession>
    <name>A0AAE0KAK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_563989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAK3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042182897" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="20994" checksum="C6A1C69CAAFA992A" modified="2024-05-29" version="1">MRTGIHIFTALALMRLAAAAELSSAEICQDFCTTSSFIRNLPMPNCGSNHADFWKCICQQEQFNVAFACCYKVNCGNKSDYDESMDKMKKSCTGYGAPIKLPEILTCADASTTFVVPLTASVTRIAEMVTPSFAGPGTRTTAKGDLTSSSPTPVTVGTSSGTPAVSSSTVAPQLAEMKKLSGGGKVGVGAGVAVLAAMGHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDZ4</accession>
    <name>A0AAE0KDZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_512909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDZ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3374874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="43519" checksum="5F53A9AE03131105" modified="2024-05-29" version="1">MDLSGVDLWTIPFAPPPPGEVVNFVDPPSQAPMLATGIYVFVPLMLVFFFCRLYTRIHMTHAFGLDDFLCIVAVVAILATSGVMLASLKLEPISPSGRHAWNLITLTYVMSLMAAMFVKLSILALYYRIFQPSPWARILIWAGMAPIALFYLISAVVILSLCVPGPSETWLFKVSTGACPAVQVKLGLGVGIFGIVSDLYIFVIPLWQISHLSLAPKRLLSPSAIGSSAGGFATREQVTLDDPTYLLTPYLFSLAELNFGLMCSCMPVITVSLKAWANKTVSSWHSVKKYYYSNTFGGQSRSEANNTGGGIRGDRYLKEELPRIPGGAMSGMRTFIRRFNRSTNAQSVPMSNFVTLNSMSDKDYHGQLRDIYGADHDDAERLAPCIAGQSRRGMNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE11</accession>
    <name>A0AAE0KE11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_262292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE11"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="24671" checksum="BA3408D2F30E04E6" modified="2024-05-29" version="1">MSFETVMPPFNASDPNARFLSASCLDFLLIELVPMAYRVTNELDAAAAEKEEGFGNVVTALGGSQSAAKAAVGGTTSTSPPAVRNMDDDEERDAVFFRLDAIGYRVGQGLVERFSRDRPRFNDTLDVIKFLCKDLWTLLFRKQVDNLKTNHRGVYVLTDSAFRPFMRMSAEPGGQAVLRAQPFLWFPCGIVRGALAAMGIEATVQAESSELPGAVFQIKTIPAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEG7</accession>
    <name>A0AAE0KEG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_482546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEG7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3375308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="946" mass="107251" checksum="6FCF4E3434AC59CF" modified="2024-05-29" version="1">MAFVDTMSPAGHTLDEPSPDPCDPSPSNRSPTPPARDHSPPPRDRSPPPRRRSPPARRDGTDSYRPGRRERTPPPAAPVRTEEEKLDAAKAEYQKLLNLRSQGVYLPPQKLRALQAAITDKTSKEYQRMAWEALKKSINGLVNKINTGNIKFVVPELFGENLIRGRGLFCQSLLKAQHASLPFTPIYACLAAICNTKLPQVGELLVKRLIIRFRKAFKRNDKAVCLSSTMFIAHLVNNQVIHEMIAAQILLLLLAKPTDDSVEIAVGLMREVGLFLEEMSPSIAHAVFDQFRNILHEADIDRRTQYMVEVLFQVRKDRYKDNPVIKEELDLVEEEDQITHRIGLDDEIETQDSLNIFKFDPDWEANEAEYKKLKAEILGEGSDDEDGDDEDDDESGSESEEDQEQKAIEIKDQTNTDLVNLRRTIYLSIQSSADPEEAAHKLMKLRLPPGQEAELISMIVETCAQEKVYLKFMGLLGERFARLNRMWTDLLEESFAKYYSTIHRYDTNKLRNVARFFGHLLASDAIGWHVLSVIHLNEEETTSSSRIFIKILFEDIQENMGVVKLKTRLSEDMLQPSLQGIFPHDNPKNTRFSINFFTSIKLGYLTEEMRSFLENMPKPALPAAAAEPEHSDYSSDSGSSYYSYSSRSPSRTPSRSRSRSRTPRKAAGRARSLSRTPPREGAAGRGRSLSRTPRRIRGRSYSRSRSDSRSRSWTRSRSRSRTRSRSRSYSRSVSSRSRRSVSRSVSRSPPPARAARRDLRSISRSPPPRRLARRDSRSASPRRDYSRSPTRSRSPLPVRRGRTRSRSDSQSPLPARDRSPLNAPTKRRRDASYSRSPSPSPQRRRNSSSVSASPAPRKRYTRSPSRGGSRSLSRSLSRSPSPPPATKRGIPAQRRRSPTPPPKGGAPRLARSYRKESRSPTPGNKRRRSYSSSRSRSPLPAKRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEJ3</accession>
    <name>A0AAE0KEJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_266144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEJ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042013029" evidence="2">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="539" mass="53539" checksum="3057D3AE2E3E8FC1" modified="2024-05-29" version="1">MSLSTLRYSLAALAVVGSVTAAPTASAANQTALDTLGYRDISVYDSCDCKKWYGNEERITFDCDLHIGEYRQSVYVDESAAAFSDYTKDHYGRLTCSGDFFGYLYAGCHDLEKKYHNRIRCLRPVPKGWFETYGKGGYGYGNDDYDSDDDSESDDDEYDYCPNHEVHDYGTCKYRHRGYGSYGGYGYGDGGYGYPSRGGVYGGYGGYGHGGYGGYGGHHHHRGGYGGGYGGEHHGGYGGGYGGYGGHNEGEYSSEHHGHLDGGYGGYGGGHHDGGYGGHHEGGYGGFGDGHHDGGYGGHGGSGGYGNDHHEGGFGGGYGGEHGGYGDHGGFGGYGNDHHDGGFGGGYGGGHGGFGGGDYNDGGFGGGYGGGHGGFGGNGGYGGDHGGFGGNDYNEGGFGGGSGGNGGFGGEHGGGFGGKGGQGGLGHGGGQGVGGVGHGGGQGVGGVGHGGGQGVGGIGHGAGQGVGGVGHGGGQGVGGIWHGGGQGVGGIGKGFGGVGGLGHDKKFITTESTEATVESADDALTAVQVLVEEAPSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEQ3</accession>
    <name>A0AAE0KEQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_277308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEQ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3375363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="827" mass="91177" checksum="73D8B8DA1B3AFB5C" modified="2024-05-29" version="1">MAAPPTPDLSTLTSSTQIFTARAYTLPQIRAIHKALHAQIDDKAARLRTQVGGSYRELLGTADIIVHMRSDMDTAQAILGRMGGRCGRTVVNAKVAGLGRFVGEREDVHLDSGKSLGTEARRRMVQGVMLALASVLRRRHGKKDDGGDGLVLAAKLWVLGRLLVKSFGGGDKEDDGSPLVAASAKKNLEQLHTRLLAGIDAILRSGSDRTARQGGVLKALTAYSLAKSCGARDVLRHFLHVRSQAIALVFVAADVSGEERPSAAAAAGAPKDVLKCLALYTRTLQDVQSLVPQKLMDALASLKKHALLDDESLQAIEGLRLDVYKRWCGDEIHFFTPFIRHDDLDGRQAKEMLSKWAQDGSDVLLKGLEKTLGGMTEFKAIVDLRTSVLRLWIAKGGKARGFDPSIILDRIRDSINGHLLMVLDTKVVKLRLVGSEVSAALEAWREGTTDRYQGLWNDDSFETDLSRGAAQFTQDVVARLYGRNDAVSKALNCYRSWFHVIDDVGQVVGQLRRHRWDNDVDEIEDEETIEHRQKLLAKDDPQKLSDHLDVSLAKALQSLDEHLKRLWNAHREGPNKGAIAMYFLRLIRDIRARLPELDSTKQAFGLASVPSLQDALTSSVVVSPLDEFATVALARKTVVCRALWEGDPPLPTSPSPGVFNFLRNLSVSMGDAGADLWSPATVAVLKRHVCGQLSEIWLDVVKSLSAKEMLREEVIQDEEATAEAGGEDPVREEVTDDAGAEEQKRPRGGKADVTPRQELFVQWFFDLCYLRFFLAASSVTGDLGEFKDLEKTIYQKTGLEGATARERMLKTSQEYWKRTSLLFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KER8</accession>
    <name>A0AAE0KER8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_277720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KER8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="803" mass="89687" checksum="1CF82051B14C70AE" modified="2024-05-29" version="1">MPGASVAAMPSSAASTPASRKASLVPERKYKCQFCNRAFSRSEHRSRHERSHTKERPFKCLKCRSTFVRRDLLLRHDRTVHAKDGGVPLHSDGKRRGGPKAARTVGGPSKSAIAIDTSALEQLEASSDGIFDVETAAMLVADMHHKATAAARANNGHYDSSPGMAYSQNGSAIMEPSVTYPNGAIGLPQWDSFMSVDETKAHSISSSASGSFDAQTANQLPPIGSHNFNGLAPALQSMINSLPPSAVGTPTPQSPHLLHRSFTPVDGSHSPAGFKAPHVSNDEERNMILDNIRADNTEHAIPEGFRVPNLQSLNRYLATYFGMFHHHLPFLHPASFEPTRVSPPLLLAVLSIGALYAFDQEQAYMLHIGSKVMVNQFLQNRENFSSRKCPLWTMQSSLLNMIFASWSGDPKGLEWACSIKSLLANMVAGNRYELKLRQEAREGRSPTRAEWVEDEGCRRTYYAVYIFFGLMTLTYNHTPAISFNEFEDLQLPSTEGMWNLKVSDDATWQDHLKVSPSVTFMDAHDNLFQGETLKYSAFATRVMINALFLEVWYHKRSPEALQDVVTEYKLRLALETWEKSLELCESEVVAVPLSAPHKGHPLIFNAKAMFRNARARLEVDLKAVQEALRYHDSYEVAAAMSNARDRVKRSSEMIKVIQECYNCIEIAVHQGVRWVARTSPTNWSIEHPLCGMDLMIILSLWLYRLEHDEEPATEEEMVMYNKVRQLFDKDMDDTYVSQLSSVVARLWGSMLDEVVVWGITRLMGESFRLHSQALVGYVDDIAASSSVSTPSMTSQGADEDSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF38</accession>
    <name>A0AAE0KF38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_264808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000012">
        <property type="entry name" value="Probable tRNA-splicing endonuclease subunit sen-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="19358" checksum="434C8805AD127435" modified="2024-05-29" version="1">MSPPPSNPDNPGFDHLEALAHVVLNNLQNQHDWTETKVHTQPNLPRQILFGLPPKRLYVHPDEQIATIKAEKDRAERIPQFPEWEWVLPLHLSEKWSPADFAAVFDALDAIPPARDSLQDVQDVNGPDAAWKLWRGPKRGKRILLATVQDDSTVAYYWMHDGLVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KIQ2</accession>
    <name>A0AAE0KIQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KIQ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042098641" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19873" checksum="66756F46AA1E865E" modified="2024-05-29" version="1">MHYSRVAFIVGAALSPAPAVLVGDDGLDPETPVLFEDGMPFDFGIYGGLSTLPSAAQTTYRWPWGTVPKWCYTEAVNNGYCNLYDIEVYDVTYSDPDTFCHAYSVGTEQAFFSDCNNSTGTYVHELSHNLDHTVTTKGSYWYWETTEWKHILGQDSCVPDPYARSSLTEAYAQAGVMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJG4</accession>
    <name>A0AAE0KJG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_478043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJG4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30782" checksum="C0F288F9887B7BD6" modified="2024-05-29" version="1">MSSQPPEESLSAPNGNDSASTFAHPPSSDFSTSTPYAYDHTYAPGYFRIGEVAGTSECSTGVESCMQRGPRDDSATSPWDHDLYYGHCAYSGPSTAFGKDWWSPQYEDASEPLSSTPELSSPQYEECASEALSSTPRLSSQENGLACLVPGCPKKQPFDRSADLDRHIKMAHSPTSEKKSPCDRKCHRRGVPFLRADHFRDHMRDIHTEDLLPRGRKMDQKWWESRIIFDDWWRCVRCLAVQVKVETDGFVCPECKNPCEEDRKRWRMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJN1</accession>
    <name>A0AAE0KJN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_477199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJN1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042129460" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52791" checksum="58BD174D70C283A4" modified="2024-05-29" version="1">MKSLHIASLVLSAILPHVSLARELAPDAALARVYASGEVHQELMDKKIASWEKQKLSGALDSTQYKSKPTSAAVRCKNGTAQVIPGDPLNTFRCNNVDFYDFVSHADLGSQTGRGASSWGWTSPNGREFVVIAQADGAAFAEITSKGQLVYLGRLPQSPEAEPSIWREIRGYKNFIVIGSEAVKHGVQIFDMSKLLKVNVQSPVVFSAVNDLTGFWNDLPVGRTHNVVINEEKQYAVAVGAQPRNSSCASGLIFIDLKDPKNPKTLGCAAGDGYVHDAQCLVYRGPDFKYFGRDICYGYNEDTLTIYDVTDKNATNIISRTSYEGASYTHQGWVTNTFWQEFLVLDDELDEVRAAGPAAAGYPVTYFWDIRSLEAPKQTGLFKSPAYGIDHNQFVIDGFAYQSHYGAGLRILDVSSLSRDPTGGKVKEVGFFDIYPENDALPNGGSVEFVGTWSHYPFFKSGFILINTIERGAFVVKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJN3</accession>
    <name>A0AAE0KJN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_495631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJN3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="380" mass="42403" checksum="4F98E17E4F5E359B" modified="2024-05-29" version="1">MTDSLHNAPIVLDNGSGTIRAGFAGEDVPKCNFPSFVGRPKHLRVLAGALEGDVFIGQKAATELRGLLKIRYPLEHGIVTDWDDMEKIWAYVYDEGLKTLSEEHPVLLTEPPLNPRSNRDMAAQILFETFNVPALYTSIQAVLSLYASGRTTGLVLDAGDGVSHAVPVYQGFTVPNSIRRIDVAGRDVTEHFQTLLRKSGYIFHTSAEKEVVRLIKEAVSYVAKDPRKEEKDWASAKTDADKIAEYVLPDGQKLKIGAERFRAPEILFDPEIIGLEYPGVHQIVVDSINRTDLDLRKDLYANIVLSGGATMTKGFGDRLLNEVQRLAVKDMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPDIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKL6</accession>
    <name>A0AAE0KKL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_232516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="605" mass="67009" checksum="85BB850CFF904D19" modified="2024-05-29" version="1">MLAEIDGREPSNGTMGRAAVSNGSGGRAAEEANGSHKSETANGSSLSWKGPDAPPATYFGYDREEVTRILLQTLTDMGYQDAAISLSKDSGYELESPTVAAFRTSVLDGSWARAEDLLSGAVAAGEAPKPGNGLVLAPGADHKTMRFWLRQQKFLELLEKRDTTAALVVLRNELTPLCEMHHKLSSLSTLLMCQSAEDLKEKAGWDGARGRSRHILLSELSRCIAPSVMLPERRLAVLLRQVDESQVFNCLFHTSAKSRSLYSDHQCDRSKFPTELLLELDQHIGEVWQLSFSHDGRRLASCGMGPTVFIWEVPSFKVLHKIEAHENDVCNLAWSPDDRMLITCGKDRYAKIWNTETGACIKTLERFEEPVSSCVWAADGESFVIGSFDKAKSLCQWNLDGERLYTWTRNHRTEDVALSPDGHWLVAMDEQMRLHVYNFITRELEYLTKLRSRATSVSISQESRFLLVNMTHGEAQVIEIATRDVVQNFHGHTGGDFTIRSAFGGADESFVVSGSEDGAVYIWHKYSGTPVERMEAHQPRCNAVSWNPTDPCMLASCGDDGKIKIWSNKERVKAYANKSQHPTGAGRSTNGGNLSEMLADIASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKN0</accession>
    <name>A0AAE0KKN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_226441</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3377821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="685" mass="74670" checksum="D6EE25F96845AE25" modified="2024-05-29" version="1">MGFSDVDTLAINTIRVLAVDATFHANSGHPGAPMGMAPVAHVLFNKFMKFNPKNPKWLNRDRFVLSNGHGCMLQYALLHLYGYALSIDDLKAFRHVDSITPGHPEAHDTPGIEVTTGPLGQGISNAVGLAIAQAHTAATFNKPGFDVVDNYTYSFLGDGCLQEGISSEACSLAGHLQLGNLIAVWDDNHITIDGDTNVSFTEDVIKRYEAYGWHTVTVEKGDDDLEGIAAAIKKCQEIKDKPSLIQLKTTIGFGSKQEGTHGVHGSPLKADDIKQLKTKFGFNPEQSFVVPQEVYDLCHKVAAEGAAKEEEWNALFAKYGEQYKTEAADLIRRQKGDLPEGWEKALPLYTPADPAVASRKLSENIINKIYEVLPELVGGSADLTGSNLTRWKGAVDFQPPSTGLGDYSGRYIRFGVREHGMGAILNGLAAYGTILPYGGTFLNFVSYAAGAVRLSALSQIRAIWVATHDSIGLGEDGPTHQPIETLAHFRALPNCMVWRPADGNETSAAYYVALTSKHTPSIIALSRQNLPQLEGSVIDKGIKGGYVLHEQEGADVTLVSTGSEVCICVDAVKELAEKHNIKARVVSIPCFEVFDAQPKDYRLSVLPDGIPSLSVEVMSTMGWERYTHEQFGLNRFGASGAYLDVYKKFEFTPEGIAKRAVATVNFWKDVPNIRSPINRAFEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKS9</accession>
    <name>A0AAE0KKS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_452341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042171273" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="15752" checksum="E6AC93A08E2D8030" modified="2024-05-29" version="1">MERFVWIFLMISLREPGGGGGGGGDMLGYMSIPVIGTIQWQCQEIYIMSCSMSYVVCPGSRKEGQVGSQKLVISSRQVPFPKNERCDVGEILGRGRQKDTVTYGWTTANIRNLLSLKDFRIGPSLLVLFIIFSDHAAYLNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLB5</accession>
    <name>A0AAE0KLB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_525292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLB5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042022169" evidence="1">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="379" mass="39687" checksum="BD75A87C1076C2AE" modified="2024-05-29" version="1">MRAVLALSSLIYALAAACPLVKRQDLPIEDYENAVAAGSGSVVGPAAGDAASESVSLYDPTVVASEIAAQVTESPAVITANVKRAVVCTTRTYNGPHVSSPADSAEAFQAFQAFTDAAIAAAKASAVPSGYALVPGFVNKKATAQDPSYLTYLSSKLSNYNPAHCATFCNSLNGCTGFNIFNERVPLIVSSTTQVPDKNVCPGLATSPSATLIKCAFYGMPLLVSTATNVGQFQGKFKVVVAGSNAYIRSLAPSLDRYEGPVSFGNASINAPAPVVDHGYLRTQTFGANVPYDPNLCAASCEAQTVYNAAHGTKRGQACVFFNSYILYKNGTNGVFTCAYYSTPYGVAYAKNKGQFDKDGNKFTIGQSYGYYADGSYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N274</accession>
    <name>A0AAE0N274_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_565493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N274"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3367530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="576" mass="61919" checksum="89908259E088EC51" modified="2024-05-29" version="1">MAAAEHPLSDKEYRDGDFSTTASESDKEKSITQLPEKQTPADVEKTADEPAVDDTTAYITGVKLTAVVVSVSLACFLTILDISVISTAIPQITDDFKSLVDVGWYGSAYNLGSAALQPLTGKIYNQFSLKWSFLVFFAVFEVGSVICGAAQSSVMLIVGRVIAGLGSSGIINGSFTIISASVPLEKRPPLIGACMGIAQLGQVIGPLIGGAFTTGYTWRWSFYINLPLGALVALPLILVHVPEQVAKQAPLKVVRQIHKFLDLVGFALFAPAVVMFLLALQYGGNQYPWRSSQVIGLFIGSGLNAIVWLVWNYYKGDDALIPVSMAKRRIVWVSSLNYGLFIAVIFGGVFYLPIYFQAIKEKSAMLSGVYILPNIGPQLFSTIMTGVLVGKVGRVPPFALFSAATIAIGAGLYGTFQPDTSTGKWIGYQILSGFGQGVGFQMPMIAVQNDIKPEHLAEATSLLVWAQYMGPTIFIVLYNTVFTTSLRSEIPKLAPNADTEAVIAAGATQFRNFVSAEDLPAVLVAYSNAIDNVFFLIAGVGAAAFFVAFFMGWKDIRPKPAPEDDFKDEPTPTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2R2</accession>
    <name>A0AAE0N2R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_487591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="318" mass="36132" checksum="86DA9613B9CB5062" modified="2024-05-29" version="1">MRHVNPAHNGTFRTNFKASRLPIHVDTMGSTLNLPYSSLDEHQPSASSTTATMSKSPSTSPSTSFTTLSLHKSDIIRFTQSPPEIYNTILPVLQGSWAPGIQSHGPYDMSYEYKMRGRPFGWPDNNREAVYCCRLIRDALAYLYDHSWEFVTSIAGSRKVGAKNTLIFRRRRVDAGPPPPLRWLSVAMMGRDRLRIIYDPEKSESADTSPDHDHLGAVVTSVKTSLEELNYFQKGSWSYNSFEFKLKGWPWVSEGRECVQVRLLLLRIVECLSSFGWQSLCTVHQRTATKDDPILDTWYFVRSTMQDNVVLDKTALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2W5</accession>
    <name>A0AAE0N2W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_81092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="61874" checksum="FFDB239115CDBDC5" modified="2024-05-29" version="1">MASRARLTLESLPVEVIELILQWLVPLQPEIGDTHPVAYDQLAEGEFWFDFTRCRRGLASLCLASRRLSVMAQPLLYRVMAILDEDQMVLFLRTLAGNPVIGILTRHVSCHLTLTSAESMPETRRALTTYLHTFEYASQPQALIQSVRTYMSLVNPDDHAPFDDIPELLLSYILLFLPKLETILLQVPVVDYPEDFPLIQRLSLAKDMFFSPDDPESLPFAKVHTLFLQGDPEMIEHFDENDCECSVPDFYGVQVPRYGVLSKAFPNLTTLEVYADDGIWTDSNFQYSLYASGQTEFTPYMSAIRHLYLHDSCACPRNMHHILRNAPNLETLYMTPRPNAYFEVEEGEEDLEVAQPDALDVALAAYGKNLRHLDISWNTAQGYEGLIGPDGQLTSLCEMPKLEKLYVQLAALYGISPTALETPMAELLPPNLVDLTLEDYWWHNCDDYEEMEDWDQYEKIRHYKTQHIYRKNAVRLLKDFARDAKERVPRLKKVLLLPRIPWTWMMEDSDVTIEYHFEEVIALFRDEGIEFLVELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5L6</accession>
    <name>A0AAE0N5L6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_440690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5L6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="666" mass="76818" checksum="3D6809B681443551" modified="2024-05-29" version="1">MSLTDLPYELVAFVVHHLDLAEVYSLSLTCKRFQFLVHEPSIAKAQLESKAPGSQEAQTARRTNRYAAELRRLVKRREAISKVSPFLIAIVAVAESWIFENGVLCYIHDRQLRVLDLNRPRSGEVVICIRKLLDEAINESHNSRRYRFQLLYYARDIVSCVYTHAKPEQISWLIVFHPWQGRILTTHRLDSSFKIFVRNNDKFLYYGTNSEYGRDGYRHWVIRSFDIENRRWLENQKLELTEMVGSDIGSTVCFEIFDNYFYGLANQTAFEVEEIDWTSYYTCFRFPTSQRGFQLVEEAPRERMWRRSHAEGPIDDRWGFLKMFRDESTSELRIVESRKEWLAGHSSARRTYYTTNIDFDSADDERTQCSVPDSSHLNVDSDSDDDDDEPAPFEKGHPYSMDAPLRSPHEVHPGDDGSTSLMYTLSKCPIRTYHPSSQTFLDLVDDPSNSEPNEQRIRIRGGSRRRRTPSELEERNRTSSTTGQEFPYTFEQTIQDIYKQEDVVFWPPDQDVGKPDPALVELYKILSPPGHQGNIQGAWDDRSVVYSTGSMPGGLSPLILLSFDPSLYLVGVRPFPNSRVPNKAPAKSDKSRGDSQLQPHSHPSCEEKGKGRETKQRHPTSEPDAAHCLGGMAMSSETANDDHRCEWRVFEHPMYQDISVGYQFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8D7</accession>
    <name>A0AAE0N8D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_548860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="218" mass="23465" checksum="FF128A1644C46EDC" modified="2024-05-29" version="1">MASSSHLNPTATAFLPGIASLPTLPDAALISTLDLLFEPSDDLHALALPTLRTLSFASYDDLITTLRDELLQIAAAVSGPDADPDVTPDACKPLHNILGSHPRLGAAKPPAAAQIQGEEQEELSEQSKKEQAQLRGGDPAEAEKLAALNEEYEAKFPGLRYVVFVNGRGRDVIMEDMRRRIDRGDLQAEEREAIRAMCDIAADRVAKLQKSALEATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8L9</accession>
    <name>A0AAE0N8L9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_562869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8L9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057517">
        <property type="entry name" value="SsdA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3374877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="719" mass="81016" checksum="5C94DB3E09460628" modified="2024-05-29" version="1">MSLDFATKALGLEPIHVATVTRNAKEVARILRKDPDKVNARNREGATALHLAVIFGCFPIVRLLLMKKASISVTDHEGCTPRTYARSGERRRHKIEQFQALGIESKKKRRGRDISIIFREPEALRAMLAKNNHPLSKTVLLRDGSKLSILKKIGEVDIGSPINVSTCGYMSSHGDMTPMPQMAAISGWKNTSIRPGVLPNNVFTGFVREAAKLLKFNLPKQPWDSPGQKEVPERFVGRWFASHIEKQLSTFWVIRLLREYLNTVDLSRMRELMDIEMPPNHKNVKIFLDHNPCGNCLTYLAVLRRATGITFSAEVIPFVLMGSRAKKAGACKNCTCESCSSGRKIPPLSRAGPSMVSDEAFEEMERNRQEDFTELDQNRPDTAEAANVPGFEIEEGPEVEKEVVDKQDIPIHDQDNSIAVEAANEVDTVNPFRDRRRTLLPKGQIIRRFRHGVYKTSPPKRWVRFPDGTSKPIYKKRRLRAVDKDDSEDGHDDPQESVVRPKPRQPVTSFNLSQSSCDSVPPREVVSMMNGVSAFFGDGSPSQRQEEPGQRSSSVQHLNLSVDRRRRGAQQHTKTESRFQIPHQTPILRMQNRPLPERSKPASPLAGQRVSNKPQQKARFLLGLKKFAYTGPSTSRQATQACSRSGSIPRRLQTHRLSTQTGISGGVQKKQAGRKPRAATKEAKIRNQSVFARAFQRHHQQQQGSQDQGRQQQQQQRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBS9</accession>
    <name>A0AAE0NBS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_240250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="34617" checksum="235FB6F74AE6348F" modified="2024-05-29" version="1" fragment="single">QSTTKNRPRSRTSSSHLSQAGVGTVSAPETTPLRSVTAGPEPIPTSPSPPGSGSGGKSNLALHAQIRHLQRQLEARTEEVKQLRRLLDAKQDAGVSEQLRQTERESRMWRERAEAAERRVGMFERLVAAGMKRRKMLMQELGEGGKEPSQDKDDSKEREDDGGAATPGGMDGPNDPARKKTRQRSPAGQRSRILSSAEHTEDEVVVNSRIRMTLRAMGGHNDSGEEEDGDFDEAGVDKTGLDEEDPSTVAAMECLMSAQKHTHYYNTPNNNSERSTSDGGGTLSASAASMWMAAEQLLQLHSPDDSVSNKYVAGRVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBT7</accession>
    <name>A0AAE0NBT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_436748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBT7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="883"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3378222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1221" mass="138949" checksum="E03A1D6F6AAF2E56" modified="2024-05-29" version="1">MEAAEVLNNDTVHPEVRAHITSLVSALGGLGVDDDSEEYKLGDDALEVLRDLKKWIRFYDEKTNRMDVARCLAEANLIGNDLLQILAMWPQNCADNKYKARIALACFEIMMPLTCPIEMDREHMTVNHHRHIPVLQLAQLGYKRAIINFDATPVLSTAVRVALPSMAIPIGDRTLRDQGIIKLILYFIRNVAMISPPPGIKYDGDETQISRSATIDAFSYQDIFLTLLTISSNMGEDFRTEDVIILEILFHLVKRVDPSKLFVSEKQVNKVKADELSAAMNKEAAMLRAYSKNAPTRHSRFGTMIWVKRENGKMSTVTGQEALLDAATRERKMDNSKTFKPPRRAVKAEMEPKDLGPPVSLDERARQQLGSFVSDFLDSGFNPLFQHLRKTVDREAIYLMNYHRSQFFYLIAWFLEAERMRKKARQEAKQVPADDDVGSFNLVAEVLNQEMFITLNRSLERAFTDKDWQLLTTVMRCFSQILLTVQEMADSGNDEDEEIADNTLSRLFYEETTHDLIANIIRSYKDQGFEYLDACTELTHIFLRILESYSKQNVDLQVRSRKRIRRKKKAAKAEDPDGGDVDQDDDDSANDEQNAEKTSQERKFDFKKFTNRFIPQAVVDAFVTFTSFYRDLDDSQLKRAHRYFYRVAFKQDMSVMLFRLDIIHLFYNMIKGPKPLDKSSSVYNDWEELAKQIIKKCVRKLQERPALFTELLFSKINSTAHYLEYGYEKQTISTNPRPAAELEFKRSTERDQQIAITVSILLDKSQSDHLEWLKKQLTQAESERRAWENAENALRRNAEAAGGETVEELPSKIAPPASVRPDSEERRTAMFKNPHLRLLMKLVGMERLALTLDETSDSTWVFPAHLTADALQDSLDQIKKAEFSPPTFEDGELAEDQLRRKSAAPPKRAAYDDDNDDGIDGLIDDDDGILFPMGGPTARKPTADDAKRPKKRQRRRRREGSEEVEGPTDEQLDEKARARRLKDLEKARKIKSDMYVHSSDDEDDAERDAEFYAKEQERRDIQAARNAELGIPAPSKDVNKPAWEKLLEEDGNTDGEEATPASAPKKTSQKKKKTGIAALLGSSDEDDDDDDDDASVSSQASAASLRSEPKTRTKRTKQRSKKTIIELSDDEDENMESTQSSQTANVEDVEMTTQDTPLTSSPGHVGEREKSQQIAVNGNDGRDEDEDDDDDDDDLVLAPAKARARPRARVRAGFVDSSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBU8</accession>
    <name>A0AAE0NBU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_242199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3378252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="359" mass="39190" checksum="E32D1F887A5E926B" modified="2024-05-29" version="1">MPPLPRQHLPRIITYYQTHHDSAGKHISVLPLLNQPSVGLTHLIVAAIHLNADAAAITLNDHHPSHPRFTTLWAELRILQAAGIKVLGMLGGAAKGSYARLDSDAATFEQYYRPLAELVRSRGLDGLDLDVEEPMSLTGIIRLIDRLRDDFGPDFTITLAPVAAALLNAEHNLSGFDYEALEVMRGQQIAFYNAQFYCGWGDCSNPVMYEMLLMKGWPAEKVVVGLVTNPENGSGFIPWNVLSNVIPLLAGRHPRFGGVMGWEYFNSLPGARQRPWEWAQMMTALLRGQRTAPEGLVEKVAAGDGIVQNAKSQAAKKGGEAVQQPEADADDGSADDIPVPVPRAFEYYSDGAGEDEDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBZ9</accession>
    <name>A0AAE0NBZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_452209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27302" checksum="BEFFF0302DF67BA2" modified="2024-05-29" version="1">MLRQINAACSSGSLITEIAILRTTTSGRLDDSLKSLLAEIQARQNEWHAANFPSLPWSSAGRAAAWFQQAEDPSCVLTTVHWASVAAHWTWIGSHEIKTAMTQLENGEEGEGGGYISMGKFVLYHVDGDLFGGGLRPPAAAAAAGNPGAVVGLLESPVVSVERILVEAESKDAFGALFEELREVLDNFAVKDGWRADGAPGGATKEEFVLVCGWPSVGRHAEFAQSAGFPRYNHIRQFVASGEDDVKHYKRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCL1</accession>
    <name>A0AAE0NCL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_451567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCL1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3377714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="314" mass="34915" checksum="6FA11B22F199A28F" modified="2024-05-29" version="1">MGQSDLEVLIDMGFEQGRAELAVKKNGGLQGALNWLEENQDKPLEELQADAAAAAEDDDEEVKPTIAHLEGENAKSLVCNVCQKKFRNHELATFHATKTDHTDFSESTDEIAPLTEEEKKAKLEELRRKAEERKANKAVAEREEAKRNEQIRQKATKESQDMKEELRRKEQIKEAAKKRQEKLDDLEAKRRIKAKIEADKAERKRLQEEAKAAREGRAVPAPASPVVAAPSAPRPAAAHTEARLRLQTSKGNIQKTYPADTTLFEVAQQLEAETGAAVTSFTMTFPKKVFEPGVDFGQTLKEAGLVPSAVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFY4</accession>
    <name>A0AAE0NFY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFY4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="166" mass="19105" checksum="5A1FBEA208339E64" modified="2024-05-29" version="1">MVRMTETRKPSADAVTRRATRSTTKSWREARAERGAAIAAVKAAVSALCDFVLENPISGPFLFMKLLGELRNMIYEFVVEESGIREVPLDMSSRDSRRQHAWLGILPKIERQRYIIPVCERPKRMGRPPNVKKTAAVMALLRTSKHINVEFSKYLYRCDPYCLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG63</accession>
    <name>A0AAE0NG63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_474531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG63"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="94" mass="10460" checksum="2E3B1B2CDC679DAA" modified="2024-05-29" version="1">MRQLQVAGGQLCICSRLSVAVPAVRCCLFPTTGPQTSDRIAMRRNSIQPTLYEPQALLFPPCLVFPGRPFRYGLRLRLSDGRGWQAQNFSGASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGB6</accession>
    <name>A0AAE0NGB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_523698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35397" checksum="194DB1E159693031" modified="2024-05-29" version="1">MAPKYDAKTTATELVQDLANEIKGKVVLITGVSPGGLGDTFATSIAKAHPALLILTGRTASKVQEAADAITKANPDVKTRVLQLDLGSLAAVQKSAAEVQEWADVPAIDVLVNNAGIMAVPYALSPDGVESQLATNHLGPFLFTNLIMDKILAAKEPRVVNISSDGHRLCPGIRFGDHNFHDGETYDKWMSYGQSKTANMLMAISLAEKLGPKRGLTAVSLHPGVIFSTSLANHMDADSDFPALTALDKKMGNREAWEGLKVKTADEGVATHVYGAFHPELKEYNGAYLQDAHVADPWTETVKSWGTSSVEAERLWKLSEKLVGQEFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGB8</accession>
    <name>A0AAE0NGB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_434366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGB8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="661" mass="73152" checksum="14A3E54098DED603" modified="2024-05-29" version="1">MWPFSSPYPELRAVDVDGKTFDYIIVGGGTAGCAIASRLSEDASVSVLVLEKGRVNDNFLSRIPLLSQNFQFPLLQAVLRLSEPIGAVGGRKALLWTAEAVGGASRINALLLTRGLPAGYDRWARDFGLTDWGWDEVEPFFRKSERALLRSKTTHRGHDGPIENRTPRTTLGCIPYVNKAARAVGLNNRPHCREINDPKANAQGCFDMDQTINARGSRVSAYQAWLNCRTATERKDHLAVCTGVIASKLVVNDDGTRVSAVQIKPVNSAKTSPVYLVKARREVIVCSGAVCTPQLLMLSGIGPKDQLEPLGISVVRELDMVGRNLSDHTSFPILTEIHRKHTLHSLENAFLFLWYFLLYLLTGTGLLAEGTTPRSIFVRTTALDQKSMTVMETDDRGRSTMDPTDPQNVPDVEIMVNPVNCLTESVPGKALFSWYTTLVQPFSRGRIELASVDPQAHPKVTYPMLTDKRDLVPMRIATRFAMRLADEFANSTGYPHRAPLAFAPGMDLEYLDSIYEQKGLLERWFGIGGSTKRGPGLPAPPVPDGKTPFDEGAVQSNNVEEQEKKLDTKHWQTVSDAEIDEYAKRVCVSSLHVSSTCRMSLDPKDGVVDQRLRVHGFENLRVADASVFPQIPSAHIMAPVVMVAERCADFVKSDWSEYKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGE2</accession>
    <name>A0AAE0NGE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_560790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGE2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042288381" evidence="2">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="25272" checksum="8105F793F491BA45" modified="2024-05-29" version="1">MKDALVNKRMMTFRVSRMNLLILTLSSLFAWLVAAQSTTSIQTGSPLPTNGFVDTSLLPKWEISYQTAVDSYLPVCGESFEIEGDDYWSNSPECRPALTSFQSSASATAMLKVQVYNTSGAVTTDPIGNGRARSCLCFAVVFTPEDDSALDLCLLISPAGEVMIKNGVAVGLQAPEDDLSRTLPRCKDYRGPESGGGSGGGLSQQAVIALAVSVPVAVVAMGTLVVLWIYRRQIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGF3</accession>
    <name>A0AAE0NGF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_560804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGF3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286637" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="512" mass="54568" checksum="679A6BAB316EEA2E" modified="2024-05-29" version="1">MSSTTLKTVLSLALAATVAALPPSSPKSLGWGYPGKEFTDCLKAKNVTFRVQSDPEYAALALTYNERLQYKPAVIGTPFSVQEVIDSVKCAAKCKIPIQPKSGGHSYASYSTGGRDGIFMIFLENFHDVKLDTTTNIAAVGGGVRLGNLAQGIYDQGKRALGHGTCPGVGIGGHFTHGGYGYSSRALGLAIDQIVALDVVLANGTAVHASETSHPDVYYAMRGAADAFGIVTTFYLQTSPAPEEVVNFSYSFPNALASVGSAVSALEGLQAFSLNASVVDGRLGVGLYVDSGPAFLVRGTWFGSLADFNASIAPALLSAIPSAPASITVDRTDWITSLIQLGGAPNLTVPLYGYNARDNFFAKSVTTTMAFPDNALRSFFQYIVDKGLNGKAPVSWFSIINLYGGPGSVIPTHNENFAAYSGHDDLWVIQNYGFVPQNQIYPDAGIGFINGLNDAMTDKLTEFGAYLNYVDPTYSAAESYKLYYGAELYNRLRKLKAAIDPLNLFSNPQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHB0</accession>
    <name>A0AAE0NHB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_524224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHB0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042183662" evidence="7">
        <location>
            <begin position="24"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="363"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="599" mass="65626" checksum="24F0D8323372ADAD" modified="2024-05-29" version="1">MSPPIVSLLLCLSVCMLASLGHAAPNSTYYNPILPGFHPDPSCIFVPEHDSTFFCASSSFNAFPGIPIHASKDLQNWKLIGHVLNRREQLPRLAETNRSTSGIWAPTLRYNKGTFWLVTTLVDDDRAQTDFSRWDNIIFKGKDPYDQTSWSNAIHFNFTGYDTEPFWDADGKVYINGAHAWQVGPEIQQAEANLDTGEVSEWRTIWNGTGGLAPEGPHIYHRDGFYYLLAAEGGTGLEHMVTMARSKSVNGPFESNPGNPVLTNSNTTSYFQTIGHADLFQDGSGNWWAVALSTRSGPNYVNYPMGRETIMTPVSWPAGKFPVFSPVKGEMSGWPMPAASLDIRGAGPLITQGDDDITFAPGTSLPMHFTHWRFPNPSSFTISPPEAPNTLRVSPSTLNLTALNGNYAGPTGQSFVGRRQQDTLFTFSVTLQSFSPTNAESEAGVSAFLTQNHHLDMGIVLLRRGYPGTSSFPGHPPPPAPITDEADDEEELVPHIRFRGMSYIPVPKPVLAPLPRAWWGRPLTLEIKAANVSHYSFSVGPADARSEMQTIITTSNDAVSWGFTGTILGIYATSNGGNGTGAPGYFSKWQYLPQGQFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHX1</accession>
    <name>A0AAE0NHX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_214264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="648" mass="73038" checksum="9EC49D5A2661DF2C" modified="2024-05-29" version="1">MEQYPELSVLFNSCMRDFNDLLLASTERRRLDEADGSGTQSIDARIIERAFDEAGRLRLWAHDHRAGIPDRSRSSLGDSLRHSPDLRDQVAHIFQFLGHLIARARASISKSEDDGDDNFPEKDSDSDSSSTSDDSASAISHPAQRKSSRALLDIFNQIQLLYHLGILLRRPGVSRRYLKSGSKTGHQSHDLPATSPEDLSHIRERIRRWNNSQTTTGVLPEEEKEVSWEEILRRTQQTSETVPEGPVSFLIERLALANARRREQFLYWQAHPDQGFTAPPSATIPANADTKSVKSGASSLFSRNTVVKSDILGAETSYNMLSGSASEPPRTMYSETVVGGSYSSRVPDVPQASQLSETFECPYCRLELSSAAMRNRMVWRRHVFRDLRPYTCTHVSCPNAEKLYPTKHDWIYHEMQMHRRQWTCQDCQMHFSSRADMSSHLVSKHEATGHLMTLNHVLLYEQALEDTHPAGCPLCPLKSDLKSVLNHIGRHMEELSLFSLPRLAEHDEYFGKDEDEKFQETPVKPARIAHSNAADRTPVTLDEGREERAAGDPVPTSLASTVTKTAWGMMTLKQRLTIALQKANTAVEHDNSHEWDAAVGNYTDACDLLSSVISRTTDPEDIKKLTSILSTYQARITELMDIVIPHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNP1</accession>
    <name>A0AAE0NNP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_471407</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNP1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3384734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="14813" checksum="92462E09DCC2AA53" modified="2024-05-29" version="1">MPPKAADKKPAAKAPVTASKGPEKKDAGKKTAASGDKKKRTKARKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP76</accession>
    <name>A0AAE0NP76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase NAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_543225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP76"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="279"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3385034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="608" mass="67406" checksum="07DC864DB53ABBD3" modified="2024-05-29" version="1">MGPPFRFLDLSEAEKHLRRLALDRYAAYAQLSALLPVGVVLAYRTAEWAVNMSSPKRGAYAGVPGSPALKSQRQSGLGVWRARLRKVQWWLSDDVILFGTIWGQRDQWIIGSFWGLWLLLLCILDTGYDYLHLTKRLGIIAASQYPVQYLLALKSINPFSYLIGASHGQVNRWHRVLARIINALLFLHVAFYLNYFVQMGILKKRLLNPVVLFGVIAFLGLGLLNSTALRSVRRHSYRLFFITHLFVAFAMPPLLFMHAPSARWFMAEALGVFIADLVDRKRDTIIVEATLVSVPNTSLVRITASIPETKIDRFGRQPGSYVILVIPPAARQLANPKSASNLLFELLYNPFTVAAIDREKGELTLVARKQSGPLTGALAALAQGASSSSSSKNSDEVKDGEVAITKTPLMIEGPYGATPKFSLGSFDRVLLVAGGIGATFTVPLYRSILHDNPSTKVEMVWAVRSADDATWAVTKKEAKSTLSDDNVQIFLTGSIRPEAAEGSTPKMTKKQKLVTGKPSASSTSDNDGADAIELSSLYKERQNQKDTTQHERPDLKRIVDDIFKHSQEDQVAVLVCGPPGMARELREHVGVWVMKGRYVLWHNEGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPA0</accession>
    <name>A0AAE0NPA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_559820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="141" mass="14901" checksum="EFAB633F04F33C66" modified="2024-05-29" version="1">MPPAPKCPSILVAVIAVLPAKRRLLPPSVAIAPSPSLPVTSMVLTVRSSFPAVSLSALTAMGSAFKSQMELLKSPEAQAFAELSRAQAKLMRLRRQQEALQEKFEKVLVNETLAIAELDEEEAVAASSSAPGARCSGVLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQN8</accession>
    <name>A0AAE0NQN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_415032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQN8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124101" checksum="7108039689AC8762" modified="2024-05-29" version="1">MSSYQNGASATNGANGVKPSSSTATSIDSGEKLATHAKPKPVPLKLKPTKADRKGVANAFERHGQVIHAVVQPLPNQGGAGTFSENKKWGKLKDDLKNLRITDYKTLKKVVMTKLRGEQLSDDKTMIMESVIQLVSNLPSHSKIRVELTNTFLGELWYSLEHPPSLFVGEKFQYRQADGSYNNIMYPQLGAAGTSYARSVNANILKQGALPDPALIYDSVMKRTEYKKHPNNVSSILWYWASIIIHDLFWTDYRDMNKSKTSSYLDLSPLYGSNQEMQNTIRTFKDGRLKPDCFADKRLLGMPPGVGVILIMFNRFHNHVCEHLIAINEDGKFTPPSPTLEGEKADAAWKKYDNDLFQTARLVTSGLYINITLVDYVRNIVNLNRVDTTWTLDPRQDTGVDVGTKKGAERGTGNVVSAEFNLCYRWHSCVSDKDDKWIEDFYHELFKKSAAEVSVPELIMGFSKFEAMIPEDPLRRPFNKFTRGADNKFSDDDLAECITSAIEDCAGSFGARNVPASMRAIEILGIIQGRRWNVAGLNEFRKHFGLKPYETFEDINSDPEVAGSLRHLYDHPDFVELYPGLVAEEHKKPKVPGVGIAPTYTISRVVLSDAVCLVRGDRHYTTDYSPRHLTNWGYNEAQYDLNLNHGCVFYKLFIRALPHHFKSNSVYAHYPMVIPSETEKIQKDLKRADLFDFSRPVRIPGKTEVTSYSGAKYVQESQEKFTATWHDSLESLLGQSGGGRLHLSGDSAHHDSQRKTVHQLLSTPEWHSQIRSFYAKITNQLLSANSYNVAGHRLIDVVRDVANIAPVHFASQVFNLSMRTKEDPKGIYTDHELYAVLAVIASAIFCDLDPVHAYPVHQAAKTVAIQLGSVIERNVKTPKAKKNDPLSGYGANFVKGLSKSGLGTSDITWSQVLPTAAALVPTQSEVFALAVDYYLSPRGASHLGEIHALANQPSSDATDALILGYALEGVRLSGSFRSSHVASAADVIEEDDGSEIEVQSKEKVSVNFTIATKDPTQFPNPDAVNPRRPVDKYINYSAGPHTFLGREASHIALAEMFRALFRRKNVRRAPGPQGELKKVTTTTAGETASVSYLREDWGALTPFPVTMKITWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR46</accession>
    <name>A0AAE0NR46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="127" mass="13705" checksum="AB56647BB7D808E6" modified="2024-05-29" version="1">MVCEPNPIKLKVGDTLALLLFDATRRGGLGIDHLNILVQGHTPPKSLSSPRETSSPVLAKSLGLDIPNVIHVINYGLRNVAAARGLGIPNVTHVINYDRPPRRPPPLRRLSTPSTPTKPGILLPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NR78</accession>
    <name>A0AAE0NR78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_434062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NR78"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041993495" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="441" mass="48790" checksum="764AA9CBD701DB7C" modified="2024-05-29" version="1">MMPSKVITLSAFLCLASLILSAEEQQCGWGLLPSPLDKQQPTCVDSRGAGNNPESWAPWTHRPHCVSAEESDWCVYTNAAVPHNGHGISIITTPERAAESLSLFEHDIEFLSHPPTSRAHNVTAEKLEGPNRPFEVRDIPGKGKGAVASRRIEKGRVILVDHAAFLATDEYPADMLREEVQELLRQGIEQLRDPEKVYGLARKGSPREDDELFSAEEDLLFTNSFAVTVGEESYMALFADLAVRWVVPELTCTNSAFIHFSETTLSITVWSARDIEPGEEITITYSEAGITHAERQETLRDVWGFNCSCSLCTADNATRTLSDTRRLAIRSLRDEVLALAQKGEFETAISRAEVLFATIEAENLTAHMAGSLYEIPARLYYHVGELEKALEYATKALREADSLGVPGPKDEVRIATLREVMGRIEREMEEKRGSGGKGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRQ4</accession>
    <name>A0AAE0NRQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_430290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRQ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="325" mass="35706" checksum="87DCBB7E7907E314" modified="2024-05-29" version="1">MANETATPDLAVGLRALAILVPLFTLALTVYVVRIWTRIRPKYRLNAADYTISIAMFAEALSIVLAIVAVSRGYGRPRFLLPPDDREAIGRTTFAIFIMALWASAFARISISCLLLRIAIERYWKVVLWTNIVVQCLALGACDIIELVQCRPIRAMWSFVPGASCLPPDQVWVIVCFFGGIGMAGDVLCAILPIAIIWRLTRSVVEKVLVSILLGLGLVAAVGGILKVIILKSWDPASVDANRQIMNAFVWIRIEELLLIIGACAPTLKAPIEGLLRRRFSLPRFGPRPLPLNTVSTMPDPSRKPPLFPQEDISQMSSSAESSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS42</accession>
    <name>A0AAE0NS42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS42"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="558" mass="60922" checksum="129542BCED824577" modified="2024-05-29" version="1">MPENPPSPLGRTIAEPDMEPNVGQPPAPLPTHRFLSAHAEPTTPNSMVAEFGEVSVAMPSALERAGAVARSYHLSRGGPHPRLASTSKTHERRTRSRSREPPASPLISESLSSSQSGSFVDSSSGIGVTSPANEMRATFLQSTVQQTRSQADNNLAVDIAMGRFGHHLVVAEIAVRKLSSDFQRLQELLTQQKESDSRAQIRQSKERAFHLPHARIGEGQPRASSLSSHDISTWFSNQDAAWSRWARDHGHSDPQRLSTGLHQSQLGELCDGIGDFARLTNAGRIPLAVLNSKEKAVHALLQGMLANFLCAGIIASPFWVFKAVPPVLGQPGKEQMERLHDLLLDDEQDGDHLTATAARAAYHHRERAQIMQYFADGGMSRRDVPTTDANESERILFECRWNYARELADGFLEGPARFLLRDPVPSGIEPPKSALSNLIDEALRFSCQLWSRSPPVRLVGWKDLGGAVFDAESRLMRLCQAHAPLLPSTRTDEAAVAGDTPPRSLRGDRRVIMVVQPAVVDVEIDSSGEIGADDNNGGRSAGSEQDAHVWLKARVMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD2</accession>
    <name>A0AAE0NSD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_468395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="363" mass="39450" checksum="08CCBFA7A9EBD80C" modified="2024-05-29" version="1">MDPNAPPPPFDDRGTEIAILSCVLHSISIPILFTRIWSRCRPVFRLGWDDWAIITAAVFDFVQWILVLIAVTHGLGRPSFYVPSSQIPTARLCLHFANHCSGWAICFAKLSIAYSLFRLRRESMPWRVFLLVMMALPVAIAITTCGFLFASCKPLSAVWNPKTPNSVCLSRSLMSKGILGVAALTVATDFILALLPLTFIKRIRRSVRERIIIAIIMGLGLVASAASICKIASVSSKLLTGDPLRDGVDVTFWGIMEIQLGIIAACVPCIKRLVEKGLVRMGLISRRCGPTFYHLENNHSSRARAKGSSRPHINQAEEPSLLNTGTATSTEDGGVTAGDSSIGLSGANAWDPAGRSDETCGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTK7</accession>
    <name>A0AAE0NTK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_500687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTK7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="58670" checksum="D3B16126F6F0596F" modified="2024-05-29" version="1">MAEVLAVVSSIVEFLTLCNDGFTLIKGLVEAKEKMGEQLMRIETQHGHFLSWSEIWGTSQNGQKSRFQQYADDHPASSREILRQLALFSRLFYDLKALEKYGIKITDTSDKSVKTLEDFHFESEVDLSPQKLRRFRASCDANMSLMKRPKFVLWGREKRLEDLISRLREYNEVLWRYGPAGVQVARLDKGVYDNIGQVVAEQLGIVLASYKLEAESATDPASARRYLALAKMANFRAQVRRIPGGTTMPRIFQANDLYIRDNYKVDSRGISTMALLRNFSQQGDLRVVLIEWIQNPQLPNKRQEAEWLAALLSAPKPDEMLVPDCYGVLDDITQTNRLGIIMRPPDNISRTTTSALPPGAISERRMPVSLRQLIKGRLSPLYASAVTLGTKFNIAKHIVDTVHMIHAAEWVHKAAIFFPEGEICDSLSSNPLLVGFNNARMSRTAALNLTLDYYQHRAKLADPSVPYRRLYDLYSLGCVLLDLGLWGMLDDLIQFDGDGSEPSTAAQIHRLASESNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTX6</accession>
    <name>A0AAE0NTX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TAP-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_412575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTX6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042233491" evidence="3">
        <location>
            <begin position="19"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="392"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="501" mass="54096" checksum="FEBD8553EF29E37D" modified="2024-05-29" version="1">MSLLSLFTTLALASIALTKPVSYPRVPCTPRSQTISWGPCSFPNLGSSPIECGILFVPVDYTSPALNETFGLPLFRSRATKPVTPSKGSILFNFGGPGYEAVQSLNSLADFLHLGVVNTLRFSCFDTPADRLIAAYKFPILAIGATDVALVDTWASTQVYSNICQTKNNNTNRGGVIGTAYVARDMMRIVDALNEDGLLRFWGFSYGSLLGETVAAMFPDRIDRLVLDGVVNGHNYYHRQGVDVDQLLSADDAFLGVLDQCITAGPAKCALATVNSTAADLAKALNRLAEEIRTAPIAVGDTVINFTFVKELLFIVIKYPSDVANAALHINNLLHRQNLTGVVDYYKSLQASIAMGDDDAIWGIKCSDTFPRSKELSEVMPDIEHMSNTSSTFGPYVASVTTICANWPFEAKERYAGDFKVKTRFPILFVGNTYDPATPVASARNMSASFEGSVVLEQHGFGHASLSQLSACTTTNLQAYFVNGTLPASGTVCEVDASLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU20</accession>
    <name>A0AAE0NU20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_470036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU20"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="387" mass="42046" checksum="5DCE624DDA8B22A4" modified="2024-05-29" version="1">MLRLKPTAISLTMTEVKEVGDRRRFYRYLKQEHTSPKESNAKPTPLEIPSIQIESTSACTSEPDSGSRQVSSASSDQEPASVAGPASQDIAEQRVEEAILPLLDLPRRRGLCRQVSDESLDPCGSHATSSDARFLPVTPRRVPRAERQARIEHEVHTDDVPELGQRSSDLVSTPPAERTSTSSRYYLRTRETVSGLDGMASSTSDQQPPVTVPSVTASPVRTRPIHGTGRDLGDLRSSRSLPPLPLPREGGESRVGARPAEQVIQETPSETSSPTSIPMTPRRFRIYNDSLPASSQPQTPQNLPEARHQSRLSGSYTVPARRLSGHSIATPTTGRVRRRLIGGRNLSPPGLQTPGFRGLYGGIENTDDSVLFEQAEGSGVGDPSPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU99</accession>
    <name>A0AAE0NU99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_165659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU99"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="274"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="546"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="944"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123937" checksum="0CA54AB6C0FA8FAA" modified="2024-05-29" version="1">MDPPTQPGEELSGDPSPTDTRRPSRYESVTGQDDQLSDNFQSTDTVRRRPEPSYGSIQTPAVGGSGPADGGQSALSELTIPRPGQGQGSILSPMLGPDRGRPRPRKPPMPRRTSSNTQAPHRGEYFSVDDGIAEVEADTAGRHHSYTSTVRRRTLAPSTLPRVQASPDEEDVEEPFEERVEPPIEPLPMEEPIEDIAVEEGPSGESPDDDEDGDISDAESFTLKDRQQAINETHPFGIRLWKPALYKKDRSVQKTAEGDIHSSPGGHVSHWLLFFNVLWTLAFGWWMACIAFVGAAICFLFAAAPSGREYGRVLWGLSAYLFYPFGKFVRLEQQEAYLDEDQGEGRSISEYEQWQSGDLEYGRLFFGPEGSRSIIGRSRRSLDSEPDETDSLLGRGRGARGSDPDLPRMKRRLFGRGQWNIGRVIFFAFFYFLIMPSLFIVSGVCYFLVFWIPMGKVTMLLLDHLRRHPLALSFESDIASARAPAAPHSSILLCTYRAVGLKYWKYTIDGTNVFLINLMAIVFFVIFDWIVLEGMLHIDNFLTSPAFLFIGGLASIIPLAYFIGQAVASISAQSSMGLGAAINAFFSTVVEVFLYCVALKQGKSQLVEGSIVGSIFAGILFLPGISMCCGAIKRKTQRFNSKSAGVTSTMLLFAVIAAFGPTLFYQIYGTHELTCQDCNNFAGPNHGGASRDCRRCYFSQTPALNDRFYIQAVRPYCYMAASMLFLSYIIGLWFTLRTHAAVIWNTDADEKKHDDHITPHSTHARPSGNPPSVGDTTGIDIRDSHLYKRILGQSLRQVGHQPRSDEQTRHNSAIPATGSLNGTPHVVPPKSSMTIYGHDNLGATINIPGFSDAENNNLVHQVAEIAATAATVAARNVHGPRRTSAHGPASISAAAQASVVGSRTPGQIRTATFPDLDDAGESTGAQGGHGGHDAPNWSRLKSSIILMGATLLYAMVAEILVDTVDVVLESFEIDEKFLGITLFALVPNTTEFLNAISFAMNGNIALSMEIGSAYALQVCLLQIPALVLFSAVYSVDIPFGADVARYTFTLLFPQWDMVTVILCVFLLSYMYGEGKSNYFKGSILLLSYLVVVTGYYFSSFGTILDSPETGISRFDTLSNDGQWTSPTPQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWS5</accession>
    <name>A0AAE0NWS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_390849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWS5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="28"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="470" mass="51446" checksum="559B62F2E43A127B" modified="2024-05-29" version="1">MLTTRSRSWWTRLVAESGFKALADSCRDTKVLCLLRFVRLFAYGASFLILVHYLSGLKFSDEQIGLFMTLTLLGDVVIGSLLTLITDQVGRRLILGIGAALMAVSGLVFAVSSNYWLLLIASVVGVISPSGNEIGPFRAIEESILAHLTVKEQRSDIFAWYTLCGTAGAAIGTLSSGWIVQGARKFLHNTTKAQRVVFVLYAVLGFVKLLLTFSLSSAVELERPETRYEEISFELEEEGLITDDEEDDGDARLSPSPKTTVLQRLRGLFPYISPVSRSILYRLLLLFSLDSFASGIASPSWLTYFFTTVHSIQPWALGTLFLVTNLLATLSNLLALPIARRIGPLRTMVFTHLPSAFFLAMIPLPSATVSGHWFSMAFLAIRACMQSMDQAPRQAFLAAAVLPAERTAVLGLVNTVKTFAQAGGLGFAGLLASKQWWVLAFGGAGLMKAAYDFLLLWMFLGLPDREATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWY6</accession>
    <name>A0AAE0NWY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35815" checksum="2F3CD434F8EAA881" modified="2024-05-29" version="1">MPNACNCPAPASGVAGVVMSSPAGSDDTKIFGFFIDQKNVLALTTVPAEYTSEDKTTYSANRFVTDLATDSSVVGYLNNPSSLAVVPLGGLTAVYGVVKTTPCQTGGSISLLSPVTMPLGVQCDTQVGSIAASSDPKHDIARIYYRKPRSGTDSAPEQKISEFSLAGPSAPFNFQVVYDGNDIDDKTYLAAYYDSNHQERHVLYQDTEAQIKDVNLETGDRYDLDKALPGMDSAGLTAIYVPDNDKTYCYYVCQGKSHHEATYLLYKATGDWDDLENKWKWSAGRKVTPITHVDKNTQLSVTSKSDMRENYIVFTDQNNVIACKHDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXB5</accession>
    <name>A0AAE0NXB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_97181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXB5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="456" mass="45500" checksum="6BD38C0DB1B03166" modified="2024-05-29" version="1">MKYEAVILAMAGAASAREIPLYSGKMAKREVPQEHSHEAVLRITNTFLQLNNPLEIQDTVFGLLGNGAAAGGAPNVDNLDCLQQFIADQAFTNAKAAGDLDGQINAILFRALERNTLTVGQASVLCNEQAVNPEIASISQHQDPASAEAAGNADIEIAVAISLASIGADPLLALQSATFAPGEIGDPTAAGNTCNDADDAVGCIISQNLLTPAVSEAEIQSAVAGGAQANAGGAAAVADAANSCGANAVVSEEKAAVSAGGAATAAGAATATVNVQAFAGALGGPAPPVISSASERPFEVNGATFLNIGAATQRSCAIQKNACSNAANSGQIEGGTGQCDTQEKACLAANAAKKMKRFHKVRQAGLDFGSCGSPAIQFAEGLDGRKEASFQNVNAADFNHGSALNIKVIADFTCQRLDSSCKADAAAVEACKGAASAAAAAKGQAAADAFNSALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXY4</accession>
    <name>A0AAE0NXY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_445848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXY4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="774" mass="86010" checksum="0EE6713597ACBB11" modified="2024-05-29" version="1">MDSAVDIDTFMREVEGENPGLALEAMNNFEYRDPNLDSDADSNFEDEDSGLCLDKNPDSDSKPGQKRRATDDSSDKLRRLQRRAKLERALGLKHAATHELPSFETAAPAKLTPNQKKRLKLKRRLARNREAMLAAAANGVQPDNTNPSQEPLPLTMSQVDAQRRRRRLAARHLDELPSPDCMDVCMSHTQKMKALRENRIERAALGLAADLTRTQKTRAKNHAILARKRAAVGLPSVIAQSERVHPPGTTATQKKRILQKRSLARKRAAMGLPPAPPPPEPVYPPGMTRAQKKAARKRRKRAEMGLTEDDAATPVIEGPQRTKTQKRQDSLKRMKARRREAAAAATPLPIDKDEDDPMAQSPDSESTMSLDSHSGSSKRTKTEKRRETLKRQRARQALAVATATILPMDDGDDDDDDNDDDDNDSETATETETDIPPGQKRTKGQKSQARLKRRKERQRAAKALLDELPLPVVEDPKPKRSRTRRRAEQIKRQKQRACAAKELLGELPLGVIEADIIPTPVPALTKTQKRMAQKKRARARKVEGMMGVSAATPFPVSQRTRTQKCNDNKKRVRVRKREDEAAEKAVARLMGRVTVKTETQTSTPGEMSMAPTAVKCEPAAAQDDTRTVPEMLAALSLDDLHTKMIKQEHSDTKPVTISGGISKKRNRRRNPETIRRKRRNKEWNAKLRFPQFLAESFSKLSISDLPGMILSYFAPALASAPAPAPVSELAPAQPEADSDNDMEPELGSDTTASPPQTPLTPHSDGGKGYTPWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY90</accession>
    <name>A0AAE0NY90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate 1-hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_464258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="472" mass="51166" checksum="8A8E5F2F975766E0" modified="2024-05-29" version="1">MSDPKTDSQTVAVIGGGLGGVILAIGLLHRGIPIHIYQAGKGFAEIGAGVSIGPNAVRALRLNTPHLLEAFNKHVTCNADAPTSFLAFRRGIPSPDHDQDDDLYFDLTNEETAPNWTASPARMAVHRARFLDEIVKLIPADSVSFSKSLVDIVETDNSVTLSFADGTSASCGAVIGCDGVRSATRRYVHGPDAGPTFSGEYAYRALVPSDVFQTVMGAERTMNGQLYIGHGATVVTYPVEHGASINMVGIRTKPGSEWTHPSWLMPTTLQDLEADFAGWDKRLLDMLAKYGTNSKWALFHYMHDKPYYKGRVCLLGDSAHATTPNLGAGAGQAMEDAHVLAGLLGARPPKTGKDIEAVFKAYDAVRRPRSQESIRLSGLCGRTYSFQEDGVGDDFGKMKSVLADRLRWLLDEDLEVHFEKAKRLLLKEGGEVVGETGVAKVQEVQKSGKGIALGFWRAGLRRLSKLLSRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYZ3</accession>
    <name>A0AAE0NYZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_111513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYZ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="424" mass="46420" checksum="BC1AFD9491EF8AD5" modified="2024-05-29" version="1">MPGEAVNDLISTQPSSNSGLQIALHPLPILEISDYITRSYQRAYNGAVVGGLLGQQNGREITIEHSFSCKASKNEDGLYELDEEWFLARLDQMKQVHKAPPLDLVGWYSVMDKTGPSPLYLPIHNQIISQNESAVLLGLHIHEIGQPGAGESLPLTIYESTLEAVEDTPKDESHGEDKVMKDSEAAVKQLTLKFRELPYGTEIGEAEMISMQFIREGGAYATAADGEKRMIEQFEQKIAVNEGKGKRRAVAREESKASTAANPDANLTKDEAEFMSALQAKYNAVKMMKSRVDLIVAYLEKQSPDFVSGKLTTPEAAKAVNVSGGKHTTPSNSILRQINALVTNIGLASSGQQLKDLEKEIIKETNDVKLISLISDLISSTAEMRETGKKFAIVESAKNHRSRQGPFDPIAMSGDYVRGSTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ05</accession>
    <name>A0AAE0NZ05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_107872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ05"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="214"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="701" mass="76798" checksum="22816940688A89CA" modified="2024-05-29" version="1">MDNHFCERCRHVSPRSISVEHTHTTPNGTLPSRFGYDHGTFEQLGDSAKTCPMCNMLLAALNSAPGMHKLKKGKEHRLLLSSDKYIKDHHIPRSVAGMTALVTNSNLRAYFHVFAEPGSPAALSGDITGRDIRNEPDSPQSLSRIQSWLGECIQGHPECGLVPLARASSESSPLVQEFPSRLIYIEAWSDGDHDEPASCILVPRSAAVHDQGRYIALSYCWGPLHQQLRTLKANLTDHMKSIPLETMPLTLRHAVVAARKLKICYLWIDALCIVQDDAADWNREAPQMGLIYQNAYCTIAAAGSSSSSSGLFHRRTVTGQIITLPYNRDGGSSNRNRNSSCSTSSAQTAVMHITPVTADIPALVQNTAWNSRGWVLQERNLSRRIILFTTGQTFFECGRRSLAEDGRALAGYQHKRLGSGDIHQGDDWAWCGLVADYTARALTCAEDKLFAVAGLAANMGARQASNRRFCAGIGVDALGLHLMWRSEKGGMRKPVLSEGRELEAEGLFQVQVQADGTRTWKRAPSWSWAALEGPVIWEPSALEARVVCELGLVGERDVVHLAPDDVRLREAQLTFRGLVVEVSRSRRTLVDDGGGFNLEGQMVYVIDINSHPTCYALLGTDDEALGWAVFDEAESNPGPYVAAVISYNSDSDDQATSGGLESSANALILEMSEDSTYNRVGMGELSRLNKAKFSETTITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P039</accession>
    <name>A0AAE0P039_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_123373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P039"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="23695" checksum="DB230227B14E6C29" modified="2024-05-29" version="1">MDFAPYQSSPPEHGRTMSPTNDGTSSPRTSYDAARRSFSPGGNGLRPPQVSPPPLQHPQPQRAWSSDGVGSSIGGGGNGIGLGSGGGGGAGGGMGDYFNALGAREGMVSEFDTSLGLRLDYEACLAYLVFPPLGAIVLLILERKSDYVRFHAWQSSLLFTVLLVVHLIFAWSRFLSWVLFLGDLVLMGWLVMNAYRDADTLDRYEVPIIGRLASRILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0L1</accession>
    <name>A0AAE0P0L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0L1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="72" mass="7624" checksum="1A5CF8A783CAB717" modified="2024-05-29" version="1">MPSSSAVAVPVTEDNRLRTHLQTKGVKFHIKAGNAKWACTLVDRATHERQRGPRTDSSSSVSSSGSSSAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0T0</accession>
    <name>A0AAE0P0T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_508373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="21242" checksum="292F7F59924DFFB4" modified="2024-05-29" version="1">MLGIIVFQVSSAWRVKTRSASDYFFQTSLIPISLISRLLLHVTNMLPPKTLFLAPWLLASWGEAVAASRPMECALPTWTVNDLSINFNFPGSQANFTLHNTATNKWEEISCALEFATLCEINGTPLDKGLYIHLQTKGPDVWVNVTSPYTCDGRTGHVTGSGERSYECAENDDYKCTAEQILVDVEFEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P193</accession>
    <name>A0AAE0P193_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P193"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="278" mass="30708" checksum="E5B1E9B119C950AB" modified="2024-05-29" version="1">MNPAKEILEYSKHYSNVYSNELPGRTGLLSAEEMEFMEKQANSSISDMVAACQAKLNLGLEYFYAVQQQLMSTQQAWAAIIAEKERYDTVGWQAGTADFTRALHTCLYMIPKRSNMGLLGPFHGVKGIGACADGVADFSSNSGSIPVAYDNGSGLPDYEDSLCESAEFENWGGLDALSSVEGDDQRDGDCEEDEQNDASRDEEEEQSIYEPRGTQNLEDFQVFDPWNAFLSDQEPFLGSTVTPAKRPIIEGYEGPESDVEIGGDSRFLVRQNHNVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3T1</accession>
    <name>A0AAE0P3T1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_456853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3T1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="498" mass="54775" checksum="ED5AC1F5F1D74FA9" modified="2024-05-29" version="1">MKVKQKSICETCRKQKIPCDGTKPSCSQCRLRDLCCPGYQSDWIFVPHTAQSDRHSGATVVSQSGIVGGRKRIKDPRPNPKYQGARELTVPRVLGLSVSHLMTLIIRSYVPEPELASLDSNSNGANTYSQPRICGCWVEVLPNLIAKGETVALSSAVRAFAVSILSGGPMPIASLASGLEAYSVALRSLQRALRSACQFRDELAAAIMCILLAELLLPTTLNSWAAHLQGFGELMQLSGPELYTSGIGHKLFVGARPSLVILGFLSRKASFLGTDEWRCLPFGLQPPSAMQQLLSEAAVIPSILERLDKASGLPPRDRAIVDRESLHDFVAVLGRLGQWETYLQSADQYPLSWVKADAEEGAISCRWFNNITDANVLTHFWAFKVICLQNIDELAGNHPGMTSSSQFSTSFRERVGLSVMISQSIGYLMQDEMKLFGPSSVIMPLRTAYDTFRAGSSQCKVELRQCNEIISGILERGYHFVPLFFEAFRDAQFCPMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3T4</accession>
    <name>A0AAE0P3T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_530231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="18883" checksum="EBFF5BDA62D06A53" modified="2024-05-29" version="1">MANKSQVDDPFSKEVLRFRAETPPGDKSYMTYWFDDGTKYGSAVVSSTFPIDGDDICPLDCCLEHPGLIEDDSEDVKELVTKLPLVRVDPAKHFAKKGKFRSEIENLIKCQGGSVPGHPLSPNIIQLLGRSADGELVFEKLSSSARTLGRFHSLAVYRSRILQLIDALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4F5</accession>
    <name>A0AAE0P4F5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_491232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4F5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="532" mass="56452" checksum="4614BAA8802BCEB7" modified="2024-05-29" version="1">MMESRVRCATWALSDPFDVREATIDGVHNALLTRLTTCREIVSSFIARIEKFNPVVDAIISLNPDALSEADRMDVQIASGNVTEALFCIPVLLKDNYDAIGMNTTGGCIGLANNKPLVDAPTVTALKNAGAIILGKANLHELALEGLTVSSLGGQTANPYDLTRTAGGSSGGTGVSIAASFAIIGTGTDTVNSLRSPASAGSLFSFRPTRGLISRAGVIPISYTQDSLGAFARSLKDLAVALTVMASVGFDPRDNATALVPPEMKHTDYSREVFGRSLREMRLGLVDGSINHTSSPETTPVNDIMAPKIVNITESIYNSAAISAALDVQVFEYRELLDAYLSGPELSGAPRPLSFNELYTNNSGRFLVIPSQYAFVETAFCSSTSNASYFMAQRGIQNLTQALKATFVRNNLDALIYPEQKNLVVKIGSPSQAGRNGILAALTGSPVVTVPAGFSPPTDDAPLGVPVGMEILGRPWAEGLLLNIARHVSDLVPVRRMPPLTNTSAEPKHFDSVPVIKPNSKNIPATYPVGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4M5</accession>
    <name>A0AAE0P4M5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_457689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4M5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="281"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="403"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="510"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="609" mass="67696" checksum="19B79768567D9B0E" modified="2024-05-29" version="1">MMNGDTYSSREGGRHGSGRDYPSSSSRRDRGDDSRRDRRDPERGGDRAERGDRSSGGTRRRSRSPADYRNRSRREDGDVDAYSSSRSHRDREREDRYSSGRDRPRPERTEREWDRDRGAARGGGRRDDDDRMSHRRDRGDRDLMDDRRSGRGGRDGHRDGGRGGGGREGPRREERDPDREFLERDRRRSASPPPKKREPTPDLTDVVSVLERKRRLTQWDIKPPGYDNVTAEQAKLSGMFPLPGAPRQQVMDTAKLQAFMTQPGGAVNSATLKPSNSRQSKRLIVSNLPASATEESLVSFFNLQLNGLNVIESTDPCALCHVSPDHTFAMLEFKNSGDATVALALDGVTMEADDAYSANGNGSAPRGLQIRRPKDYIVPAVVEDPHYDPDSDVPSPFVLDTPNKISVANLPPYLTEDQVIELLVSFGKLKSFILVKDNGTEESRGIAFLEYVDPSVTPVAIQGLHNMVLGEHALKVQKASIGITQVAGEMGVNAMSMLAGTTSADSDVGRVLQLLNMVTPEELMDNDDYEEIRDDIQEECEKFGKIISLKIPRPVGGSRQSAGVGKIFIKFENSEVATKALRALAGRKFADRTVVTTYFPEENFDVSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4Y0</accession>
    <name>A0AAE0P4Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopropionate ammonia-lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_16488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4Y0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="38"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="390" mass="40828" checksum="1407A2685FD3FD15" modified="2024-05-29" version="1">MASGSRNPIILNPLAKEPWRFLSSADDRARAFHQSMPGYSLTPLVSMPQIAAEVGVGAVHVKYEGDRMGLPSFKILGASWATFCAVASYLKLPLNSSLTVNNLRDVLTGWASSHSQKPTLVAATDGNHGRAVAYMGRILGLPVKVFVPGGLDNDAVQAIVNEGAAVARVRGSYDLTVNLAFNVAKNMLGGILVQDTSFPGYTDVPEWVVEGYDTMLSEIDEQLENQSQPADLIIVPVGVGSLAQAVVTHYRSLGVGTKVLTVEPDTAACLYTNLRGDVAGQKPVPLETTGPTIMAGLDCGTVSLCAWNLLNAAVDACLSVSDHEAHSACGILKTHGVAAGPCGAASLAALLRLGDKEKKDLGLGNTSVVVLLCTEGERQYSVPAAGLATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6F8</accession>
    <name>A0AAE0P6F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_444382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6F8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="111" mass="13048" checksum="372C18BC3B6EABF3" modified="2024-05-29" version="1">MDSVKPADKPLGMRVNGKQWHAPKKAFRPGGGLTAYSQRAKERVAMAAMKTKEKEMKEEKEAERQRRITLIKEGKAKKEEKERYEKIAEKMHKKRVERLKRKEKRNKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6P5</accession>
    <name>A0AAE0P6P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_444493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6P5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="41841" checksum="F2E7BE392DF18C89" modified="2024-05-29" version="1">MSRKAANGARGATATAAAAGGSSSALPAISSDDMCPVCKTIRYLNKDMEFLINPECYHSMCSNCVNRLFNDGPNQCPYASCNKTLRRRGFRAAFFGDLKVEREVDIRKRVAAVFNQAEEDFETLRDYNNYLNMVEDLTFDLVSGDDASRSKAEAELQRWEAEHKADIERNRKAGREAEEITRRRLAAEREAARQRRIEAIREAEDEKRERALSREQELDNLAQAADGQRVQLKRRGQTNRATAAAVDALMSSNSAAASAAMASADVGRLSIRGLKEKRKPAAAEGPYDAFGGMDFVPSRYKLSEDLNVPWLDKYRIARDYVTGGYSFDEYTSRAMYEAFAGLGVFIEDEKEVGIGLDASRVSAISAGIAAVGDKMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P753</accession>
    <name>A0AAE0P753_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_517732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="102"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1355"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="865"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1404" mass="157555" checksum="48FD60C1E504DFE5" modified="2024-05-29" version="1">MDMATEVLIAHTGQRLQINASQFASLDEFKNSVARQSAIPVQCIIALTPQGKPLKLQTIQVEKEIYVYDSRLTQSFVPGAVPPPKPELPTPKPYNVSNPPNSLDDARSVQSWQELFNTRRAWARKVVEDCTKMANTAHERYGEMDVMLRCLDAAVANLESVIKGLEPKYADLKKWAPAAQADYGVLAAGWEQNLSLARSIPISPAMVRFMTGRDAGGTKGRPLRQSTLEDLVDLDTAQKAGRLAPAALRKFNGRIADLDKVATRLFGDAENLFREFERAVARSALSHEGEALQLLHDIEAVYKKVDTDFQTTLEYTGSNRDALQQASKVAANHTERLLPTVRTRALEMDEMLRYATQARNNLAAESVELMRNITDITSLSHSVKSQVNAVNQEEELATFDYLRLIQQVPYMYASFVAEALKRREWYDKLKQDSATLANEMALFQEEEIKRRRRWLKSVGNAYGPEMSTPDSNVPGLEVNLLGEEEQWPAMTRKDLEDFYSLFQAQKADPVLVSDIGKVIVDITSPTRQQSKRMKAFKNGSIHEAALGRSGLMIRGDDDLLRSLQDDKLRLESKLKTSESRVRRLEDLLHRQTQASRPSLGNLFQLPSQQLPDRNDSTISIRSPRSSEDRRKSVEGTDVLVNRIQQLEAELGTEKERSATIEKELDERRTLHDNLKGQMEETNSTKKDLLENMEALKREHVEERKSLEDEIKRLQARLEDTEDEIEHFGESRENEKASYDDKVHLLELEVEQLVKEKHDEALKTEGQVDFLRKEARLQRERMEAQERQLQTAHDESKGLSKKLASLSEAADTQLRALRDLWEQLSPDDIVPEDLADLIEGLSGRVADSLAKLRSVEGDMSLVRHDLDSAQNAIKLIRTEVAAAKEKLSGEELASIRLREVLAEEKAKVAALEGEVADGRQQLSQLRAKIADGETGSESLRKRLEEEEERITSVTEELALRQSQVGGLENEVQHFRSRLDESQAQLSELTVRFDSRTERAKDLTQRLYSQNERLARLLERLGFSVTRQGNAMVIQKIPRSERNESDPNSSLRRSGTLNSRVMADSTDLELLYWMDSSDVGIESANYEAYMASLGLFDMDAFSEAIYRRVKDVEHLARKLQRDSRAYREKTHLLQKEAHDKIAFKHFKEGDLALFLPTRNQSTGAWAAFNIGFPHYFLREQESHRLRNREWLVARITRIQERVVDLSRSLQHQPSASRSVGAAETESLNDDDNDNSMNNNNENSDNDNPFDLSDGLRWYLIDAFEDKPGAPSTPGLAKSTVAANNVEAMSDMHTHKGASAGRGGLSAGIEGVSKTLSKSLESRRSSTGSKKALPFTIGVSRGKDSALASETNSLRAAPADALAATSPTQHSTAAQGSPRASVVQTADQGNDAVQVEVGNPTHPPMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P756</accession>
    <name>A0AAE0P756_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_444666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P756"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="47"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="24347" checksum="55259E2270325FDF" modified="2024-05-29" version="1">MSFLPRTLYGSDPSFTPLFRLLDDFDSYSREVQDPQAAGGRTRGHRHHAPTFNPKFDIRETEKTYELHGELPGVERDNVQIEFTEPQTIVIRGRVERTYTAGTPPASLEAPKAADAITEKGEDHNSSHKATVEDEEAEAAKEQGTQVATKKDTTDERPKAPLEKYWVSERSIGEFSRTFSFPTRVDQDGVSAKLNNGVLHVTVPKAKKHETRRVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7C2</accession>
    <name>A0AAE0P7C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_461527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7C2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3394639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="54850" checksum="6B97E90B839D4A1B" modified="2024-05-29" version="1">MFLHHSSRAARQQQWRLYSGRLGRLATACCPPPASAASRAFHDSKSLRVVKPVLLADIGEGIVECEVIQWFVEPGARVEEFSPLCEVQSDKASVEITSRFAGVVKKLHFDAGQMAKVGKPFVDIDIEGDAKEEDLKVLTPPEPASKLESFGLKETPTPEPESETEPLEQGSALSGNATPISRPQKGTHAGLATPAVRHLTKELDVKLSDIDGTGRDGRVLKEDIYKFVERRNSASTQTPNPSAAAASSSFSLPELPTSGSQKETPLTMTRTQEMMFKTMTRSLNIPHFLYADEVDFTELVELRGRLNKVLAKAGMGDSQVGKLSYLPFIIKAVSMALYKYPILNARVDVEGSSGKPMLVLRSRHNIGVAMDTPSGLLVPVVKNVGNLNVLGIAAELGRLQSLAAAGKLSPQDMSGGTITVSNIGSIGGTYLSPVVVEREVAILGIGRMRTVPAFSSAPGEESKVVRRQVCNFSWSADHRVVDGATMARAADVVRTIVEEPDVMVMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7L5</accession>
    <name>A0AAE0P7L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7L5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="40194" checksum="42CC7067BD402569" modified="2024-05-29" version="1">MLRSFLAKMTENAAKRLKTDITIGTHNGHFHADEALAVHMLRQHVPTYTGARLVRTRDPKLLDECHTVVDVGGEYEPARNRYDHHQRSFATTFPDRPTKLSSAGLVYLHFGREIVARRLAVPEDSEQVALIWRKIYESFIEALDAHDNGINAYDPAALAAAGGIEKRFSDGGFTLGAMVNRLNPNWNDPVPKDPQEAQAAEDKRFELASTRIGEEFDRDLDYYTQAWLPARGIVVDAFTKRPDFDAEGRIMVLAGQSAPWKDHLYTLEEQGQEVGKVLYVLYPEKPGPDAKWRIQCVPKSKDSFQSRKPLPEAWRGFRDEKLDELSSINGCVFVHAAGFIGGNKTFDGALAMAKKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7X0</accession>
    <name>A0AAE0P7X0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_445038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="471" mass="52359" checksum="ABDE7015CA7AA7BB" modified="2024-05-29" version="1">MATPVPTARSVHWADELEQDLSKSEARRLISNASSLRWKQGLDGHIIITVGGRVQSPMQYETGWQGSEGGQVTEAALLQDALNQAEVLRYVSAPDGRIWVNGPDVIDPSASQEAGHAGHLSIFPLFVKMNSLDMGELRQLLDNRADIDGRARAINGHIKEALIDIACEFGIEEFVNMRRRFAPQSAAAPRAITPAVEEEDAPPAVSQAKSWISSFNISQLVQFIRNNILLPDLNVPSDPDTSDAEREESADDENAGNEEPAEEQHTAEAETTSQDESPHSTNPNLDKVISHIKGLNTILTNKEMSGDTSHLTNNWKLEYFTEHHLREHLRAITQFLLEFNHRFATTSTSDDDFTSAYNRAFVFDNQVPVTHLRELVFAILSIKNLAGNERRQMTAVQDRLRVAESLFEQFATVVAGAADDEEAVRQEWVAFMERERRLENVPMPTWDQVLENLCPEEAAAMRAAAMAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8A3</accession>
    <name>A0AAE0P8A3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_462812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8A3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="99" mass="10796" checksum="94F032CF1B99E139" modified="2024-05-29" version="1">MFVDILELLSGRSLTILLVGLAGLRLIGHLITCTENETVPKIWKQVIILRFISSLGPQKMQIRAVAFGAEAPSIHVANLSVILRAVGESKVIDKKKHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U015</accession>
    <name>A0AAE0U015_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotide kinase 3 phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_395544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U015"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002548">
        <property type="entry name" value="DNA kinase/phosphatase Pnk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="469" mass="52936" checksum="703F4C3BC603BF6C" modified="2024-05-29" version="1">MSPGGFSRLSSTNSKRDTPDSERVSPPPLKRKAAAQSTISKNAVANFFTPTSQKPKDRTTWTERSPNSDTPATLLVGKYVPDKEENSKSATLTKERTKIAAFDFDSTLIAPASGKRHAHDAADWKWWHHSVPGRLRQMYNDEGYQVVVFTNQGGLTLHPDPKSKTPKIHQTRVPAFKQKCGVVLAQLDIPITVYAATGKDIFRKPRPGMWNEMKADYDLDDSDIDLEHCIFIGDAGGRAAEVKGGATIPKDFSCSDRNLADNIGIKFQTPDEFFLGEAPRAFTRDFDVTSFEYTEPDDKDSVVFEKTNKQDVVLFVGPPGAGKSSFYWKHLEPLSYWRINQDILKSKEKCFKEAADGLKVGASIIIDNTNPDPEIRAQWIELAKKHKVPIRCVWFKTPLQLCEHNDAVRSLNKQLNPESRSSLPKLAFNGFASRFKEPKIKEGFQDIVEVDFKFQGTKEEFNIWARYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U029</accession>
    <name>A0AAE0U029_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U029"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="253" mass="29058" checksum="AC331486DE32BF18" modified="2024-05-29" version="1">MYQQAVVLCRVVQKHLRQGRWQSILAKVVRQACSWFHRKQVHGYMRISAEQAGWIEKSGLPPEMWKTSTGEELRGVQSGSRRKEEVAVQLLKVGVQRVDVGDEPLNEPLGVLMLDLRVNVDRWPDSEQQTSNKGEHLEYEGTRRVLDYLGLPTGIDVEAPTKIVLLSRGEKRHYGSFQHRKAARQARARRIDKRQQELNGNECLRRKTRSTDTGEGSSGLRSMWSSVRLRDGRVSESMLRNEEEGREQSENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0S9</accession>
    <name>A0AAE0U0S9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_558344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0S9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF23">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042259354" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3386707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="356" mass="37958" checksum="AF2D39F9D9A73FAC" modified="2024-05-29" version="1">MLFGTANLVLGLLWTRSASAALDPRHRFNGSPKYHHDKDTTKFCVSWLDNTGDWTCGRIKNELDVSLSDFHGWNPSVSADCKTLPRQQSFCISTGDRPAPLPGWPSMQTVTVSATRISTTTLATTATVNRTLTAISTATLNRTLTSTAISTLNRTLTTTALSTVNRTLTATATATLNRTLTATSTATLNRTLTATSTATLNRTLTATSTATLNRTLTATSTATLNRTLTTISTATFNRTLTTTAATATLNRTITVSILTTSTSTATRTTTLPPVISTVTATPTAARNGIATPLPPQPNMVTNCQAFYYVRRGETCNSIAAKLRGSVSAQQIIAWNPNARSDCTLLFADYFACVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1A6</accession>
    <name>A0AAE0U1A6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase kappa 1</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GST class-kappa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_468623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1A6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="7">
        <location>
            <begin position="50"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00083519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="30930" checksum="88B3B2DE887AD115" modified="2024-05-29" version="1">MLRKRLTAPSATATTTATATTTLRVLTRSLSQSQFTMATQQQQQQLRNKITLYVDTVSPFAYEAYYVLRHDAVFRNVEVSVVPIFLGGLMHKCGNTAPINIKNKDKWINVERIRWAKAFNVPIVSDMPPNFPPLTLSIMRALCAISASEGGAANDQQQQPHLTKALDALFAKYWVEGVPTHQPEVLRSVLGEVFGAAEAEKILAEANTPGNKALLLQNTDKAFDSGAFGLPWMVCTNGSSGATEGFWGVDHLGQVAQFLGLRDRQQQQQQQQQSAGWKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1P2</accession>
    <name>A0AAE0U1P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_392956</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1P2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="181"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3387591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="41231" checksum="949BE3830F20A073" modified="2024-05-29" version="1">MSPTTIHLRSETKPLERRSPLSPASAKALVEAGFLLRVERCRNRTYGDDEFEAIGAEMVPAGSWADAPREHIILGLKELSEDDSSLPHTHIHFQHCFKNQEGWAASLSRFVRGGGMLYDLEFLTGEDGRRIAAFGYWAGYAGAAIALIAWAHQLLHPGTAQGRVPRFDSALALADHVKSIIEASIDTNGGQHPRIIIIGALGRCGKGALDFCLGVGIPRECILEWDMEETSRGGPFPEVVASDIFINCVYLGPTRIPPFVTFDSLTTPERRLRVICDVSCDPNSENNPIPVYSSYSSFDSPTVPISRKLDGPELRVVAIDHLPTLVAREASDEFSRLLLPSLLTLNRRESEGVWVRAEHTFAEKVRELPGGCSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3M9</accession>
    <name>A0AAE0U3M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3M9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14398" checksum="4A03D04E5FFAF9A2" modified="2024-05-29" version="1">MPPTSEAPAADAAAAAPVAIGIPLSHSPDGVGYKLIELPQELLELLEGDDPPILTISASPAAALLKTADKTYSLRQKNTSNGLTLLTPIPSSPSESSNGSGGGLRSIATVHETIELVAGAGEAAPTPVARGKWHEKFGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4C4</accession>
    <name>A0AAE0U4C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="692" mass="78603" checksum="7E68F19053982282" modified="2024-05-29" version="1">MASSGNVTLFTVHVFIYHDPFLASVFLADLFSDFPDSAWRLPQLIATPPRPPPNPDVINGTPELAGRTEYPPYVNPRRGVGRYILQQPLPGSTAVGEISDAIEKQFSVAKKLHAYFTIFPQGHDYDQYPSSGFPPWHDKPLSPSTTISEAVTYDISALEVPDLFSDVPTVHLVLETKAAALRRIIQPGFLAEELGRGYERRFNSWNLLESCYHSSPFRMSDYYASELQRSLRHWRHAKYALSYLFGKQRDEDSGEARQEVERQVRKLQKDKADAKAEISTFVGEWASWVPSTKPEHAIEIPVGELRDEDVEDTVQKVWRGKQALIEEWKARDSTKAMRTALEDDYLANNPGARRGDDQHSSTAHYSTDNILTTHQVNVLEEGAPVKTISFRNEDGTLSTTNSTFTIKSGIMLWGQMFPLYHGSLQDNFTNNADNVSAELPGGTIRQHVHTYRSAARNGEWKVRRYYSNWRSERNHDAPPKDLTGWVICHKDLDPIKLIQRARAINPYGEAISLGNSHIDKDVLYINRYDWLNPPRKNIEEQFQAYAEPAVGPCPPPDPEADYYNDPCVSNVKSHGYFVAMDAQGWGLDFLRAYKQECESKGNWPWRRDMSVVERTFRKNTGEAFGAYVRKPSEYEFGWLIFSGNKHSQHDADELIAIIYDGSYEVLSGLYHDAERETETDNASAAITTEHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4I8</accession>
    <name>A0AAE0U4I8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_507983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4I8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="321" mass="36245" checksum="B5480E603B976B66" modified="2024-05-29" version="1">MTCYDDKISDGNLGVLRKFSVRLWVLHVARRNDDYNLMESELVEKATTHIHSLVLKPRIWKWVSLSFYPFMGKVPTCDDGHQQPSGGISRNFYTFEQACKTPFAHIHRSVKKPRIWKYLRHQKDIMLSHPPIREGAADLEVGFHSLTKLAILQQTYKVQAAMMDNNDNLRCVSQSYVDFQNKDTHPHITVPQHAVDTDQEVKYILQEQEAEEEKGQYLSNHYTAMIQSKPGISSRLKSMLMDVIDLGCQPWNSPSSPFMILSIASASERGSASRIPAIRSSYMIPSPEQITVSGVIPKAPQPVDEEILAHGPGILPASSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4V5</accession>
    <name>A0AAE0U4V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4V5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="386" mass="42241" checksum="52EC1D1B20B83274" modified="2024-05-29" version="1">MPLPVAAKAGIIVVSVAVAAAIAIYESPEVRRAADDIRRRIAIALHSLGDNVDPNRRDPLFNRPEDADGFYASRRQEPEVDGDEESRKRQREELMYWNSRRLEMQEKARSERPSPPIRGSTFDDFLHEDKNATERGTLVYNTGADFRGPAAEEGLVRRRIEGVRGLNASMIANPFSDEHGIDFDEHPGMELNEKHPLSPCHDEVMSDIYDATPLNPRSPVAVARTLSPQSKPVVPEVLFDFDSDSQPPKSESATVDQTLPSSNASQSERSETLDRELGDDEYMTAGQADRHDAYSSIQAWAQGSHPGFYSPLPVSPQAPLSEADVISRGDLTPTDSMSMAGSGEDVGNDGVSSKGGDYDVMSEFEDGVATPNSWSEVGSVVSEEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U724</accession>
    <name>A0AAE0U724_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S1/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_2189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U724"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042028466" evidence="8">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3392829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="311" mass="33612" checksum="BB65BA5A2746E3C9" modified="2024-05-29" version="1">MLARTATLLLAAAAATPAFCWDGFGHQTVGFLAQKYFSSEANATFGALAGLSDGFDIGDAAAWADTVRGVDNLPWSKNWHFINPKGDDPENHVCVMNYPTDCVSQNCIIAAIMNQTSIVLDTEKPLIQRRNATKFLLHFFGDLHQPMHTSGFKYGGNMVRPVCWNTAAPCDGTRSLHGVWDSSMPRKLRGVPDETGPEEDKAVAVAWAEDLYDLQQAEGVNGGDVCADLSGPRCILNWAAESNKLVCSNVLNKGEAWILGNDLSKEYFDENAGLLNTQVGKAGLRLAAWMNAIASRLAASDDGEWLGGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7G7</accession>
    <name>A0AAE0U7G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_531744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7G7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="503" mass="58305" checksum="889F5DE6E438BBD6" modified="2024-05-29" version="1">MTRLMDIAVPRLDFVLSTRFWVILHVVLWIHRYLRLLVHCIAHWSYKSKIPQEKPRYTSDDVTVIIPTIQNHDGLQELAARLRTIVACKPAKLILVTTWNKHDALEQVAATLRCPHDPHATIVEVLHVDKANKRLQVCKALEEDHVKTPITVMADDDVEWPPTLMPWLLAPFADDKMGGVGTCQRVKRVNRAEAGLTTRIYDWLGAAYIERRNFEISATHSIDGGTSCMSGRTGAYQTHILKSYDFLSGFKNEKWGKYILNADDDNFVTRWLVAHQWKTWVQYHPDCEIETTLETSIKFLYQCSRWARSNWRSNWTSLMHEKHVYTQQPWCTYALHIATFTSLAFIFDPLIIYSCWRATEDWTPASRQTFLLAEIIFMFAFTKTVKLMGLFRRNPGDIIFLPVSIVFGYFHGLIKLHALFTLKETSWGSREDGDEDNKYRLLDEKLPRSQSMATPSGPALTDPPRRSVAHPEPRLPWMVPAKDLDILKLYCSAMDRLKCWVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7H0</accession>
    <name>A0AAE0U7H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_443520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3393264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="19901" checksum="16EC54BA4620F867" modified="2024-05-29" version="1">MAKWYTLTTFDIVGDLIFAMPMGGLDRGDFHPWVTFVLRGTRANNVTSTMCNLGMRWLVQLLFGLIGNAAIVQEGKFSEDMVRHRLSIDRGKEDFVQALADLTLEKARKEVRSAFSNAVQISVASVTDLPYLDAVINEALRLYPPLPVDLVRVVPPEGAHIAGHYISGGDNWAEPAAFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U888</accession>
    <name>A0AAE0U888_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_53539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U888"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="566" mass="62781" checksum="B19970F71C34FBEF" modified="2024-05-29" version="1">MNNDQFRKLVLANAAKPSAEKKNGASSSPGAPPTPSTLGSRLKSSIPMTPRSVITGASRVDFLRQLSEKNNQTFDKAQKKQRTSMPKGSKFAAGYVDRAKTRQEQEEEDDRAARLKALEESFRKEEIDQATYDRLRSEIAGGDLSSTHLVKGLDFKLLERIRNGDDVWKEGEGEEESYHNSGEAEEQQKEAEPEEDPDDILEQLESAEVKSITREKTEKKGQYATTTLNPGQKRSRNQILAEMKAAREAAAKAKAESSLGSRFKKIGEKKTPGTRIERDDKGREVMIIVDEDGHERRKVRKVEPRSREEEEKEKVAFASGSVLGMEVPEFYKKQLAEQAQKEAEEARKEVKIFDDEDSDYDPLAGLEDDSDDDSSAEEGEAKDDNVKDSKPELPSGTDTKASPNDMPPPPKPGASGGVRNYFKDSKTALTSAESYKAPSLNDASFLAALAKAKAISAAEKSEEEQKAAEREERLKKKLQESNRDDDDLDLGFGSNRVEDEADGEDDAKVKLSTWSGRNHGNDDDDEDGGGGHGDKSKRKRGPKKRKGDKNSFEDVMRVMNRNKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JWV9</accession>
    <name>A0AAE0JWV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_424352</name>
        <name evidence="11" type="ORF">B0H63DRAFT_424552</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000020">
        <property type="protein sequence ID" value="KAK3365440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JWV9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3365440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3392762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="60102" checksum="CED6B45EBAF59959" modified="2024-05-29" version="1">MLFNIGLASLYLAYLVAFSTAVHGAVAYFRNRKFSKANGCEKPRNVAHTREPIIGLDFLLECLRNAKSGHYIRYCASRLFRYGFTYITRRATFDTIHTADPENLKFMLATGFDNYKLARLRVNAMAPLFGSGIFTTNGPAWAHSRAILRPSFTRQNMAPLLAMMERHFQMLLRQVPKDGSTPFDVQRLFFCFTMDTATEFLMGRSTNTLDPSRHTEADRVFVQDYLDCCFEAVRMIASGPLQAFRVSSRSLRVSRDRAWAYVDRFVDDALAKREARRLNPNKEMMDTVDKEDYEKGAEYNFLEELAAQTTNKTLLRDQVLNVLLASRDTTAALLSNMFYELARHPEIFAKLREEALSKIKGELPTEAELNNMPYLRWCINESLRMYPVVPGNTREAVRDTILPVGGGEDGRSPIFVKKGTPVLYNLYAMHRRPDIYGEDVDEYRPERWDGLRPGWGFLPFNGGPRICLGQQFALTEASYVTARMLQSFETLVPRDAEPWVEFYSLVMCSKHGVRVSIKPVKSVAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXZ9</accession>
    <name>A0AAE0JXZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_456129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3366423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="161" mass="17801" checksum="9D24DA4485A3211F" modified="2024-05-29" version="1">MEAFRRARSLQSGVLNSSFVALSKSSSWESCLAASSSAAILYLLLHMPPRSVPQLFGGVTGSINPCIVIGQLLGIFWVPESPWWLAQEDRMEEAQIALRQLASERVDTQRRLNFIVKTIEGERELQMCTGSTFGACFQGVNLRRTEISVGIYCIQVLSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K085</accession>
    <name>A0AAE0K085_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_84947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K085"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3367668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="524" mass="56890" checksum="E47E801F1CF41878" modified="2024-05-29" version="1">MASSPPDLEKTSAGEAVQVNTADASSGDEAHSALRPPTARKKVDIRVPPSLQRLNDWIESLSGFEARGITRVLPEERQPPSLASDVQVAILWFSANISANNLITGLFGPLVFGLGFGDSVMCAVVGGLLGSMSTSYMSIWGPQSGNRTMVVLRYFMGYWPSKIPCFLNIVLMVGYITLSFIIAGQMLSAVSDGSMTIAVGIVVVAIVTWFVAVFGMYLFHHYERYAWLPQLLVLFVLVGSAGPHFDATLQSVGEGAVLAANRLSFLSLCLYVPNSWAAAASDYYVYYPEKTSRLKIFLLTLTGLWVSFTLVYMLGIGLASGLASNQVWTDAYATSTGALIVAAFDGLGGFGKFCGVIVALGIIANSIPGTYSAALGCQVMGRYGEAVPRWVWSCVVLVIELVCALAGREHLMVVFQNFLALMGYWVMVMIMIVLMEHLLFRRKTAGAFDWTRWDDKEYLPIGLAALVAFLLGWVGAIMGMYQIWYIGPLAELAGPSDIGVWVGSGFALVSYPPLRWLELKKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0B3</accession>
    <name>A0AAE0K0B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_84346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="935" mass="106586" checksum="EEEB7BF6F3ABC2A7" modified="2024-05-29" version="1">MSQTKNLDTSTISQLLRELNESREKQNALLERLIDALTSVEGQTPQETATPTKELEESSSPSVEGDGGKDDRASIVFGDKFFDHFDPRRRGIHQDQIALYKPAEPNHEFTGGTKLPPHVDPAEVVAFEPGTGTTSPDWKYWVPVYTLTGASESSSSTGGNERILVYMKSEGGRPDLIPPWELREVNGQFYHVDDLHACHPIPGPHFNNSGEVLKFDVPYSHMPFMARGRFAASGMTVDWTDVQKSIGDLFSVPADNRLPLPFAFSKNELRLKCSAGEVDTYLRNARRFFSSLRDKGGTFYIYDFDTNMNALPYGLPGNDHPFLHPIRPRPSLNLNRTATYWKAAEPALFGEQMGFTVESTKISVLPPTECGKMWDKAPLWFEPKRSMTWEETLKQATTSPVIRWPNNMVEPAHGPWYRLVCFEGLSLVTGPGVTLQDVSRIVFGRDFSCPIQVRWSSRRAIPPPPSPHDIDRILESHMYCKRRSTDGNDFSSSWKQFHFTWFDIVSMGDGQPKTHWRGRPQNWKDSSWRFGPLYGDENLSLCERAFTVAIFPWCSREPRYQHEDWEARRTRVGDQLDFWTILLLVPPDSFAARHLHAGICPAAGILELIGAGLSEAVEAWEQVRNHLYDMLDDGGQILYPDRHDSLLFDDDTLARSRKYFWAMNSLDVFIAQISDVLKEWDDFWDAREDMLRAFESIHQDRLERYKPGQRVPPRIDDESLPRVLTQIQALKDLLVEFNGFRQRAATLREGLFNASSVIESRASTRLGENVKLLTYVSIFFLPLAFCVAVWSVNETYDTSSLAITATVVSVATYFIVANLQNGTSILSRFYNQLRKRVVRKMTEYHPSNKEETIWVARGKAFSSFRPERTKEQPSEWYVLYFFLVKIIPQVITFRPWKKNLGQGASRDAEGSEALPPGGETSPKAEEESHTEIFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0K8</accession>
    <name>A0AAE0K0K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_504583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0K8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18817">
        <property type="entry name" value="GH43f_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042143550" evidence="8">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="428" mass="46469" checksum="8B192C3F08E0A7F3" modified="2024-05-29" version="1">MSWKAKFAPVAALLLLAPSPTTASPAAITYTNPLVNQRADPHITKHTDGWYYFTATVPEFDKIILRRAQTIQGLSTAAETTIWKRKSSGVGSGQVWAPELHFIDGKWYIYVALGVSGQWKIRAFVLEGTGANPLTASWTEKSLIKTNWDTFSLDATTFLANGTRYLVWAQQEPSRTDENSSLMLAAMVNPWTIKGTAVAISRPTLAWERIGYKVNEGPAVIQRNGRIFISYSASATDYNYCMGLLTASASSDLTNPASWSKASSPVFASNADTKQYGPGHNSFTMSEDGQSDVLVYHDRGYRDIKGDPLNDPNRRTRVQKLNWKADGTPDFGVPVADGATVVSCVIGRRGHSSSSRCRCSSRVQVQFETKTATGGGEGVVADDTFFRHVGLADSSADVSFEVCGGGTSGQYLVLGGDVRTWGCRAWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K189</accession>
    <name>A0AAE0K189_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_71864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K189"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="335" mass="37970" checksum="31ED497B74340A31" modified="2024-05-29" version="1">MSKPIFVATHPRACSTAFERVFMTRRDILNCVHEPFGDAFYYGPERLSERFQDDEETRIKSGFSGVTYAQIVDKLQEDISHEDKRVFIKDIAYYLLPPNGQPATTAPSLVSKGAENVVNGTATITTTSSSDEKPKNPTVLPTDLLRQFHFTFLIRHPRRAIPSYYRCTVPPLDKVTGFYHFMPSEAGYAELRRLFDFLKAERIVGPDIATGKGTGNGITITVIDADELLDKPEDVIRAYCAEVGIDFHPGMLSWEDPESKKLAVRSFEKWNGFHDDAIGSTSLKPREHAAKTPTIEEENEQWRQKFGAEAQKVIRECVDANIPDYEYLKSFTIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1C1</accession>
    <name>A0AAE0K1C1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_488049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1C1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="96"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="359" mass="40012" checksum="1C172B60E257A7B4" modified="2024-05-29" version="1">MTGKDLSPLQPSLFVQQASVFEDLVVRCVRYAFANIPPRIGRVFFCKEVVRPFLRFRMLRHGSFKPPISWWEHNGSSFKGIWIIKDPAEKPDFVLYYAHGGGFSMGSADFYLEFLLSLVSLLTSAGYHNPAVFALEYTLVPNASFPTQLRETIGAYEHVLSVAEDPSIVCVSGDSAGATLILSLLLHLGCTEADGQDRSSQLRKPALALLVSPWVTLVSTRHKNTDSDYLDVQQLHRYGKQFAGSNVFLRDPRASPGCCKDVAWWRRASPSNGIFITYGKEEVFAAEIEELIGVLQQANVLVGSKGEAGGIHAWPVASLFLSSTRGKRLHGLKTMTREIRKRVPPRPCHQEEEKRVMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K249</accession>
    <name>A0AAE0K249_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_489120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K249"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3368739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="206" mass="22964" checksum="B99700E0643D264C" modified="2024-05-29" version="1">MHRTESDVARASALYFLQPVDQGLSAHQEVNDKVRSECENVIAGTRSDLAYSRFVTIVENRDAFAVVEYKKRGVIHDDEFNAALIDITPQGTNIDTIVKNIIARNRGADATLFKKSSLAIMKQASAYAISHGTRYVAVFNWDVLLLIKFCCFNPAVADDGVGSYCEISYIPNGSMLQQPQIMRKALLGFLFEAYRFHTAEVPAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2E6</accession>
    <name>A0AAE0K2E6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_564926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2E6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="802"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="928"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139869" checksum="6A4FED4E31879B0C" modified="2024-05-29" version="1">MASSLMSSQANGALNGTPTKNGALNSVPKSKRFSDIPSTIDIPVQDQDDEAVEIDLEVLADDPTELCTLFEMEHAARTYWMTVALAYAKQKKVDFAIDMLKQGARVLDSNPREKLSIIACLCWMYLWKSREAPRVAPPGSTPDEAKTKESYLTAATTSLNEASRINPAFPPLFLARGVLQLLRASLQAPSKAPGAADSDKSELLRSALKSFDDALRVSQGKNMLAVMGKSRALFSLGKYPEALAGYQQVLSKMPDLVDPDPRIGIGCCFWQLGYKDDARQAWERCLEINPVSKIANILLGLFYLDASGHIPINSPEFAPLYKKAMTEYTQKSYKLDKDLPLTCATFANYFFSRKLFPNVDTLAHKAIQFTDVNAIASDGWFLLARKEHFSGDIERASDYYRRADDARGGAERGYLPAKFGAAQLSVLKSDLGEAKLRLEKMIQQSKNHEAMILLGILYAEEVFANQYAVVKEDKSAEAKKAIGLLESVRSAWKDTKKNLAPDSAVLLNLARLYENDSPDKALQCLQQVEQLELDQAPRPEQTNDQDDEAIRASLRKSLPPQLLNNMGCFYSQEEKHELASEMFEAALESCVRIDKTSADIDTDALITTISFNLGRSYESRGNVDKAVEVYEGLLKRHGDYTDARTRLAYIKLRKQPNKEGPDAVAKLYQDNPSDLEVRALYGWFLGKINSKKRPSNINEDPELRHYKHTLQNYDKHDRYALVGMGNLHLMSAREMRRETEQDKQKRSAAYGRAVEFFDKALQLDPKSAYAAQGIAIALVEDKKDLKTALQIFIKVRDTIKDSHVFVNLGHIYAELRQFSKAIESYEIALSKDGKANDAGILSCLGRTWLNKGRAERSLEAYKMSLQYAKKALAVAPEQVHFKFNVAFSQIQLAMTIHGLSETQRTSAQLQAACEDLESAIKALDEIAASNQPPYPKHDIEQRSNMARNTQRKQLERASASQREYEEKNKEKLTAALEARQADLRRREEEKRKQEEIIRERQEKIKKEREEIAARDRALVEQRLEEERRRLEAEMTTDSETGEKMKRKRKPAAPKRGGSSEPRAAKKGGSRRKKAAAADTGDESGDDEERERRAPPKKKQRLTSRKESAKYKSEEIIVDSDEEEDPLDRAERALEDKGTPVSDDGSSRHRRRRSNRRDEDDDELSDRMDVDQEADAGVNNDNDEEEEDDGESAAVNARRAQVKRPRRGRIVEDDSDEEESAGPARGGDDAQEKDTAMSDLDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2F8</accession>
    <name>A0AAE0K2F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_489187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2F8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="64"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="385" mass="43241" checksum="812A61CDC546E6C8" modified="2024-05-29" version="1">MDKFRRIINRTKHKPPKDDGDESGPEINTAPGAPHALDLLPSLPARRHPLTPDLPSAFSSPLTPLFTLPYELRHQIYLLVLGGTRTIHLDMRYSAATAARPHTTVGAFLHTRRWRWRVSTCHRDPSAQAAYDRCGEGGPPPTACALHDTPCTIGPDPLNMMLSCRRLYREVSAFLYGENTFHITTGVMILYTDRLLAPSLAAQIRSLVYGLSSQSVETYAREHLAIEPGWSAYRAILGAIPKAFPGLIKLELVALAAGRADVSWRYPDAPAWDRGGEHSEIHGVDGLKRALFRPMDDLVRAYRGQLRECAFVMEQVVFNSLVLNDLTEPTARTESRSDWVQFWRRLDSVACDLGENNVTAEEEEGYWVRRIVSRTEFWFNPAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2H2</accession>
    <name>A0AAE0K2H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_534553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="307" mass="33578" checksum="96C6589E2AB0FEC3" modified="2024-05-29" version="1">MSDSTEECKAVSPACPVEATLYGYSPNLGGNAFYTVVFAVCALAQLYYATCRCFCRRRKDPGGGKNWTTYSVLTMVGCVGEACGYIGRLFLHKNPWNGAALPIQMVLLMVSPSFLAAALYTMLRPLVRHFGAEHCNRFVPARYWTWPLVTADLVGFFLQCGGGIVASMSERDPKFGSIGTAIMIFGVSFQAVVMAVAGLLVADFTLRVGRRHGADVFALLQRRLRIFLLAMTAALLLILTRCIYRIPEMAGGVGGPLMRQEAEFMIFDGLLILLAAVLQTVVHPDIFASDTQDSQTQVYELKTLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2H9</accession>
    <name>A0AAE0K2H9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_72994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="365" mass="39985" checksum="B52776825F5B6DCD" modified="2024-05-29" version="1">MSGDDGGTYAPKSPDLSSFYSGDPTCQSQSGPSQPQQLQGPLSQPSQSQFTPPHLHVQQPLSTTFFQGPPVNHHHPYAQQPHQLATSPHALTQSTPANTPTVGYSPHSLSQQYLNYSAREPPAQSPAQTHSASAPGYTVQAQAPQQLHQQQQQQQQIQPQFYQSYLGAQYQQQFSQFPIQAKVAQAQFYSHPAPAPQGAQQQQQQQQHGQHQQVKSESQSPSGTMPPKRAAAQAAQAAAVEPSPVKTKFPTARIKRIMQADEEVGKVAQQTPIAVGKALEMFMVALVTKSADVAREKNSKRVSAQMLKQVVETDEQWDFLRDIVSRVENEEKAAKSGGRAKAESESEEEVPETKKVTRAGRKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4T4</accession>
    <name>A0AAE0K4T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="100" mass="11827" checksum="9A154C33802EEC0A" modified="2024-05-29" version="1">MLIIKRESWCPGFYDMARRGVWVFLFSFSFFNDLRMGPNDGMNMTHIYKQGTRMGGQKTLGESRVFFFGLGTQLVFYFAVFTSPATRIFFVRWWYDTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5B5</accession>
    <name>A0AAE0K5B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5B5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="32215" checksum="3F11EFE2CF1F7F66" modified="2024-05-29" version="1">MASQQPVNKRIADVEDPAGAARRKKRAKRVKVNKKPPTALDALRQQIRSTSDTAYDVATLRELPDIAIELGAALDLANGSTAFFQPHGGTGFFGDALAKLEADDPLWLPPPDHTERDPDCHFVSCTRQHTYLLLGTPKFLRNDKHPNLHKWHARLANQETAQLPTHVNFSRGGGWFNNAIYQYQDGKPDWACTVSDSRELEASKVLDSELATAVFLMKMTLQVKIAEPIPKPIITIRQSAAAKMPQEWDDPIVLSILRWIFSTPTSLGRSNPASSSGRSSPAAATPPPDAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5I1</accession>
    <name>A0AAE0K5I1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_485929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5I1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="451" mass="49617" checksum="FF21AE7BF0E02DCA" modified="2024-05-29" version="1">MAAAQPQPENGWEEEMIVEIKAQCLCKAHTFTAQIPSSALPLSASYCHCNSCRHVTGALHSVDAAWPGGTPENVEQLKRYDLFPSSVALLFCGTCSSPMFFEEHEPVQIQGKEEDKITYGVFTGVLRDPVVANVGGDDGEKEKKKLPQPLVRFKDHICIEDTKDGGAAVWLRRQTEDASAPVARRWLGRRDKSELIPPMEHWPPVAELQQKQPLAEGDGDIPIRCHCGGVDLVLRAGAARREFAAQKEKGEEELPWFVDPATFKSVGSLDGCDSCRLSAGVDIFNWTFALVKHLGYAATNTPGGDGYGFPKSSIELRAALEAEGGKRDPRLGTLAFYVSSPGVQRYFCSRCSACVIYAADDRAEMVDVAVGILDAPEGARAESAISWSLGGDIVWKQDMMDGGWREELAKTVLKEAEAWRVARGYPKFWKRAEREAREAAEKKAAEKERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5J1</accession>
    <name>A0AAE0K5J1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_305801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="319" mass="34885" checksum="E18EBB14FA5CC6BD" modified="2024-05-29" version="1">MGRDKLRQPSRPPPAFDPFVESWLDGLPPSTTKPSAEELAQWRLDERGGVGRDFFITSVVLRVLSLIFAATVTGLVISIVALQDGDRYAGLDRLIPVLVVCPIIILWNAAEFVTLCWLSGRGISFRIHVWADGLLFLGAAIATGFLLVDVVMGLGSYDDVLDTASKEIASACLLILVTILHTFLFFFFICNCLDRREKKKTKPRVMYLPTGQAVLVTSQPVAAQPAIGLQQLPTEMGRPKNSSASLGEVAIARDLKGVQEGRKGHEPHALVIPPPSRPANHESYKKDGKDEEITGISPQEAALKAKLVQLPIETSHRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K6G5</accession>
    <name>A0AAE0K6G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_316966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K6G5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042090850" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="142" mass="14698" checksum="EA855D5B4229212E" modified="2024-05-29" version="1">MLLKTATIAAASALLFGPSASAAAVPQKRIPVIGAFAVSPFRDCPITNGTITQLTYGNDCGKCNNFWAGSTMKSIDVKGQVADGKCVITVYNTADCSDPGIQSGPSCWAPEGGVKGWTITCPWADPEQTYQPPCAAKPTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8P6</accession>
    <name>A0AAE0K8P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_453496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8P6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="17406" checksum="827415776B405620" modified="2024-05-29" version="1">MYQYQGDTFRTPEQKYDIAEAIIAQAYPLKFPLPAGIAATMIIRRRKAWRRSFMELDQQPGMHASVDFFGNRSRRLTERRTPEQKYDIVEAMVAQAYLLMANRFGNFPVQRSQLHVVSFSAAPIQAYRQGPTLEIGLLACYIRRDLDANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8T0</accession>
    <name>A0AAE0K8T0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_550774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="593" mass="63979" checksum="EC3662E79CFCE62F" modified="2024-05-29" version="1">MTTPLQMSVIAIDAGPYNPVNGPAVNTTSSQGAVVVPAGTPLLEVWNVPQQVAVKDPAWSNDGSIYPVTVLLPPAPSPAWRLPLAVTVSLTGSPVGWTSNRGIVYGSLLDPATNQLVPVVESDPFVLTSQPQIAVCTGFRLVTGRSFLNPIEPNYQFAIPFRASGDWTWTIQDAANAESIPVTAPLTTRMELNFVVWPATGGPAAAPPVLYPTTPLLRSKADFGASYPVQVQRWSYPNILDPVLTTGPTPTRDQLLVFYIKRLVTTMWAYGQSGRGKFQSRFILDPSSHNMGPFGGVFLLDPWVNPPANHFVNDWDLAAVLQLGCAVALGTTGAELFDSRWIVQYPFGYFLPGQLFGQAATSTQCNNPFWNSGAWNANPYVPNPYDTTRSGLITHSWIEVQLNRGQGLQYYVIDVTHALPAGPQNMLPRIGVYGTSSQIVPGALPFNYTSGNPVIDLYFPNLRKPKASIAEAKNVERHDVLPKFNNASPTAQTLLDLIDPNGTAKIMLHDLLPAVDRTTLYMVLALPTDVVGTSDDLPCPSENQDPVNGRADSAGSDNSPQLTVQMVVYSSAAIARDNPNTARSTPEKSSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAU1</accession>
    <name>A0AAE0KAU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_514058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="20803" checksum="02BA6E0EB99EE4C4" modified="2024-05-29" version="1">MRIFAATPTQRIPSPDAGTPFQRLIRAGFDPCTPANPPGARVVHKKLRRITPHDPREDPYIAALLIALAQKQRRLHLGDDDNSGGSQVLLLANLHGDEWLYIYTSMVSPEFLDGLDNPSRPPPPVGGAQSQPGMVIYRRQLALESYETLPWRLTVVVRDAGLATREYVSTDLEDKPQAEEAVAEQASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KD88</accession>
    <name>A0AAE0KD88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KD88"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041982933" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="209" mass="22355" checksum="0E39CD29AD69FBDA" modified="2024-05-29" version="1">MKSSFVATLLAAAAGSAVAIPMPMPLPPGIPTKAAATTQLAALTVTPYVDDGAYDRDLFPTWNTVSGTCNTRETVLKRDGTNVVVSSACAATSGSWYSPYDGATWTAASDVDIDHMVPLKNAWVSGANAWTTAKRQQFANDLTNPQLWAVTDNVNQSKGDKSPDAWKPPLTSYYCTYAKAWVRVKYVWALTITSAEKTTLTSMLSTCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDS4</accession>
    <name>A0AAE0KDS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_480742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDS4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="486"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="590" mass="64901" checksum="E0D59C4EEBA6A967" modified="2024-05-29" version="1">MAEFAACLIGIISAGTKVAMVLSKVASEVGSAGKEAQVMAREIRSFCTILRNISQTVDIVKEANQAAHCSEIIFDMTAASQQLFTEILDLVDSTQKVTVGPGGAKLNLAGRIKWAMNKPKFMFLRTAIEAYKSDLCLLLGSLQVAQSVDVQKSLMPQTTMAADEPVTQPERASRVISQNLEELALDYQASLQELEAARYALSEDEEEDPFPPMRRLEGSSADNRSPTATTNPRRDPKLVSMIRSLREEVGSLCSATSSVYSTNTTSSIYSSISMHSARLSQLVEQLSLDDSPALQDLRRTSLAMSIHEVQPHRDSPNFSNPISYGLAPPSGRPIPRLPRNSASASTSPVLAVPNASPLLPNRALKELRQWPGGVPPWDNTSVTLDFLRAFIVPCTAIMDEKKASLFWDWVKVAAEDLSRLHSRSKLVYMAQVMKAYALQVPQYTPEQPPVPPGPLSPGFPGAASEEEEEEEEREGEVSKSPSVEIFKSLRVSMNDTTTKILPAALRKYKINADDSYSLYLLYQDSGEERLMLPEDKPLLLFKQMDKLGKKPMFMLRKNTSITTGPISTNLFHPAYPNPFPAYPKSGPAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEI3</accession>
    <name>A0AAE0KEI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichol-phosphate mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_264899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37011" checksum="E0D84942F2CD770A" modified="2024-05-29" version="1">MTGIITTFPVTVHEYIPNPTGRPNHAVCTYEYGVSSDSAAKEKGKKNANANALVFIGGLGDGPHGVPYVRAIAAKLLLSSSSATDDASWSVFEARLSSAFTGYGFSSLAQDVDELEGLVRYLRKDLGKMKVVLMGHSTGCQDCVAYGLRRRRDNNKRREEEPDKEEELDVDGLILQGPVSDREAIAMTMEKGEMEESVRFALAAVERGEGADVFMPRGLLPEPFKGGSPVTAYRWWSLAGVGGDDDFFSSDLPEEKLTEIWSSQRQPILILPSGEDEYTPKHLIGGGMVNVVERWRSFCPPGIGSGLSGLIPGATHRVDDRNAQDWLAARVVGFLQGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF97</accession>
    <name>A0AAE0KF97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_279203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF97"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3375439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="22501" checksum="A1862D730904C309" modified="2024-05-29" version="1">MQCPGYSLPKAASSLPPPNLFYHCKDLLHQYIPSAVMKIHLTNLEPIGVSYLGTTSRAKGPFIAEPRTLDSPTAVITNDRGFRLAHSVMFLPKSLLYMHSYNGWLKLAVLLRASEAVSTTTSFDIRALSVTFIRLEHPACLLSQVLSTEASVCSGSHLSSRKEGGHEARLRRAEPYGFAQKNEFRHITRRDSVTLHPRCTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KG13</accession>
    <name>A0AAE0KG13_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_275742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KG13"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="464" mass="49680" checksum="6A181EB9DD4A92B0" modified="2024-05-29" version="1">MASSKEIQQTSRPLTHRPSMSSNSILGGLSASRQSHSRNNSHSVLVGSLNGSHRVTRRKSMTNTGANVAAVTAALNEGGDRAMALPIAVSSRRNTMSKNGLSRSAIVGSLPSPPASLPMHKFVTADGSVNMQDSAIDDELNGMSGDDEDPALHNAHLRRASDGQPLGKEGRKSSRPELRCDKCGKGYKHSSCLTKHLWEHTPEWTFTSKLLISKHQQVQLLEAASVLVAMNNNPTGTTPPDSARDFNSDQDSASPAASGYSEQHDRSSADTTPPPQSDTVAVANASYKSFAKRHSSGSGFARSYQSAPYLGSITGSIPNGSGFGHFRQLSQDQRPTSSGKNATGQEDRDLAAAVELLSCSFGSNPGSRTVHLPADAPPVPPLPAQYLEQAWTGTSFINSFPSGPPESFTRGPPESFTRGQPRRDRDDVKMEESGESVMDDDDDDMRSRARSDEDDDGVFGRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJE5</accession>
    <name>A0AAE0KJE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_477473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJE5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042043899" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3377598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="37685" checksum="891886348E2AA0FC" modified="2024-05-29" version="1">MLHSLLSLAVLATTTAVGAALPTSPADTPKCTTPQKRNSWHDTSDADKKAYLAANRCLLTSPQKQNIFPGAKTRWDEFVALHQLHALQIHTTGQFLPYHRYYIKVLEFLLLECGYHGPLAYWDEPRDAGKFSKSLLLDTNLGFGGSGKGTQNCVTDGPFANLTVNIGPGFKSQPRCVNRKITDAFSSQTGATYVASAIKGSTYKEALDAIYSGPHLLGHMALSMMNGDSITSSGDPLFFMHHGFVDKMWRDWQLKDLTKRLKDISGLNAQDPAVGFSEFSGGIEVESAMWGKPTPEMLAVTPDPTSGDGGKKELTLGHVMSSLGIIPNATVADVMDTKGGYLCYEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJI1</accession>
    <name>A0AAE0KJI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_225953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJI1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269062" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="60393" checksum="29F86D8252821DF7" modified="2024-05-29" version="1">MSSLCLLTAHKPTTTSTLFTLLLIFTTLASALQVTPNSPCASICMDSPDLDKSDPKSSNTKNKDITCMDAAYASVAGTQWKSCMSCLQTSTFSQGLETDQMWFLYNMRYAVSYCIFGFPNAVGVGSTPCSTSTACGPLQAGMQHGIQNPSNMSTYSYCYAGGDDTMEVRNYEKCTACVSAEGHTEYLANYVVALEAGCKQQPPPGRVVGLSGTVFVSETITIVDPDTLNSDSHHGPALSTTVIVGIVVAIVAIILIISGVLFVCLRRRRNKRARGTDKQEFYDRIRHQRQSSLSFQCQTHMASPRHRPGAEEPLPTQDDMADAPWPLTQDVRDASRPSSIWKGQDPELQDKSQAPPYSPEDPPFDEKTALSKRGSSGLGLTNVPLHNLKTSLPTMPPHAYTTPSPASMFYSPTDFRSPMSADSVRSTTGLLPAIKKYVPAEYAGTSPTQQRSPSAFSPVLPTPISAVSPHHKGYPWPDQHRRSSAALAPTSAVAPRLNVNINTVNLSPTTAPSPKGTSSRYSLAAAATWRSQAPKIKESGSPVESWEIQTAFAAPPTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJP0</accession>
    <name>A0AAE0KJP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_435697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJP0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="89"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="729" mass="80170" checksum="99CA7C030708106A" modified="2024-05-29" version="1">MAESSMGDISNWRSIVTLLVFVFTNIIVIFPFHIPFYIPRRLSNAFLDALSWLRIISPGKDTQHGESENEKRRAWARLRFPMNFVTAPIIADLFLLAILAIGRQEVYEGTIGVDSIHPYDIMAFFITLAYIAISIDASGLIRYLAFKVLQWGGKNGNRLFFYLYSFFFVLGSFIGNDPIILSGTAFLAYMTRVSSNIIHPRAWIYTQFAIANIASAILVSSNPTNLVLAGAFGIKFIEYTANMIVPVIITAIVLFPFLLYIIFANEDLIPISIKMHELPEEIRAKKPVNPNIPHARGVAEEEENNNNNNANEEQGKLLSLEEIMNPFLDKWGAGFGAVIMAATLITLLIVNAVGSPQGEARPVIYITGPAALVMFCWDVASGWAHRHETREIAHKGKREVEEARRERALREEEEARLAALESRKEAGTGTEETRPAVGGEQTAPPLQAELAQGRSSSAGGGSNEDRAVTDQDKVALKKQEPAVVDPNSTSERPIDPGSSTEVDEKGQSAVDAERSRTPNQPGANKGRATLVSQCALAYTWLQETFPSVTAVVAHLPFALIPFAFAMFVLVQALVTKGWVEVFAHGWDHWVDKTGTIGAIGGMGFLSVILCNFAGTNIGTTILLSRVIQAWLKIHKDNGIPISERTFWATVYSMALGVNYGAFSTAFSASLAGLLWRDILARKHIHVPGIDFARENLPIIAISMTVGCVVLIGEVYTIRSDNAYLIPDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKC5</accession>
    <name>A0AAE0KKC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_418148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKC5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042063639" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1247" mass="137430" checksum="8D1577B02F84DC2F" modified="2024-05-29" version="1">MQPKTVGWKPHTMRAPVLVAVIVLTLALAAAVEVISQKSQRQGGLSLSNSIDEIPLASKFAYLYATTIIAVVYSIVWTWVDLDIRRMQPWLELSRPGGAVADSSILLDYPFTFLAFIPFSAGRRRHWPVLLVGLASMVVFWGITPLSSAIFGLQSVNVEVDMAMAVPSTLASPQEQSINTDTTILYAAYGSTGLGQLLPPFTSPKFGIVPFSPMDTTRAHLPNESWTSPTTMLSTELNCWPAAITNLTHLEGSTPAAPSYKFSNGRGCETTPFGFFQSSKQHNTTSMLLYVGYDDHATLDYHLGGTNCPKSSRNQFLAIWALLDKNRYPHETAMTALFCEPSYWKQNVSITVSAAINEPDEQSVVILGPKERLSQDEFNSTALEYLIGTGTPPATATLDYAATQTLEPFFTLLKTQNVAWPVTNMVSFALHLMDVPAASLQNASMLAKAFELAHKLVFSIAVAKSMSTSSDYMDNPTKLGKVQGTVYGIVVSRAISAVLEGLLLLVALLGAAVLYVCLTAESKLSSDPAAMGFTLSLLKSSRTLLSRFATEDCSDTATLRASLAGHRFALHEGCPGELQEVNALQYEVENHETRNSPATMHRQEPLYSPVQQCSRHNTYKGHELETLQVESAAPSASGLGKSTPRKEPEYFPVQPLELKPLTGVSLTLLLLGGVSALTYLKKQEEKLHGLPRPTDNFEIMQLLENYIPTVLATLLEPLLVLLTRLSCILQPFHDLQKGKCSPEDTLEARYTSLPPQLVTLRALLSRHLLMAALGLICILSNALTVALGGTFNELPVDIDYPAIFRQERNTNFTRDQFVESSISSNQYKDQWYAEWARLTRNTSLPPWVSADFAFLPVTETVPRQGDKVVMRTRTRGFGADPKCSPISTTTSSTHSFVDISGILKHKANPAFNFPSQNGTSIACTAFFVGNNATNDRSALEITGSMAGANASRSLFCLDKLALGWVRLDSRRSAPDSLQSTIIICETVMRTAMFDVLFDATGKVVEFSQAGEFEDMSRYIAANVSRDMIQQMNRYMATSVDTQWHNITNTHDWFNFILKYRLNTDLVDPAKDIPSYDLVIPAAQDLYKSLFAILLGQNLDLFELSNLITFPGVVTERETRIFLDETSLIVTIGILCLTAVVLVALYVRERRAFLPRLPSTIASVIAYVAAGRATREYARQENGKGKTDKPTELLRTYRQTYSFGRYIGVDGKLHVGIEVDPLVMPVDGTMLQKKQTGLGLVKRTPWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKV4</accession>
    <name>A0AAE0KKV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_547580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKV4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042061170" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="161" mass="17374" checksum="D58BC344D649CD84" modified="2024-05-29" version="1">MKLSPILFLSAVFGSAMAQSITLPDLPDGSYIISIGSDGKPTEGPTSQPTSPLRVLLRPPCGSAMNDFYNYGWNAFYNMCAAGGSHKWPQGTVITQYQGTSVTYMCSYTTNPCSTAEWADAVNWASGNCIGRSNGWMEPGYLHVPAWNKRYGYAKSGSSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLD4</accession>
    <name>A0AAE0KLD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_235165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLD4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="248" mass="27338" checksum="51F8FCAD23CC51D8" modified="2024-05-29" version="1">MSGVWGWFGGAAAQKRKDSPKNAILDLRTQLEMLQKRELHLQRQIEEQDGIARKNVTTNKTAAKAALRRKKLNEHSLDQTLGQIGTLEQQINAIESANINRETLAAMERAAVAMKQIHGKLTPEKVDEAMANLSEQNELSNEIAEAMTSVNIGAGAIDESDLDRELEELQQNELDEKMLQTGTIPQHDAVNRLPAVANGDRRPPRTPLSNNPAIAVLNPILAVKGKATAVAEDDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLG5</accession>
    <name>A0AAE0KLG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spb1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_495938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLG5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="639"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3378407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="843" mass="95240" checksum="3B0FADE7CECDFBF1" modified="2024-05-29" version="1">MGTQKKTAKGRLDKWYKLAKERGYRARSAFKLIQLNKKYGFLEKAKVCLDLCAAPGGWSQVAAETMPVNSIIIGVDLTPIKPISKVITFQGDITTDKCRATLRGHLKTWKADVVLHDGAPNVGTAWVQDSFNQAELVLHSLKLATEFLVEGGTFVTKVFRSKDYNPLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCQGFKAPKRIDPRLLDPRSVFEDLQDPTPNNEAKVFQPETKRRKRDGYEEGEYIQFKSIPASEFIQTVDPISILGGYNQLSFEQPKNGDVALMALAKMAETSEEVRQCCNDLKVLGRKDFKLLLKWRLKVREILGFPSKKALATPLGEEVAEVEDMDEEMKIQEDLQKIKEKESAKKKRERRRLNEQKQKGILRMQMNMEAPMDIGKEQEGPKGEDSMFRLKSIDETAALKRIAKGKMAVLSEAEARVDRDSGIGSSGETDGDSDEEEDRLETQLDNMYEQYQERRMEADAKFRAKKNRKEHNDEEWAGVSASEHEDTDLEGFEEESSDDDSDTEETNATNKALLRDLDNTPQNSSGLSKRAMGFFSQDIFKDIPGLMDVDDEGDPADEAKPDVEMVDVEIPISSNEPETLAARPKRKADATPKPKAKKSKPTPTNEDLFLVDKDEESDWEEVEKKTRSTKPNIDIITAEAMTLAHQLASGEMSKEEMADKNYNRYAFKDRDGLPDWFLEDEKKHDRPHRPITKAAAAAIIEKQRALNARPIKKVLEAQARKKFKQAQRLEKLKKKADILAGDEGIPENEKARTIEKLKAQASRKGKRAPVKVVVGNGGNRGMGGRPAGVKGRYKMVDARMRKEMRAMKRIAAKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2G9</accession>
    <name>A0AAE0N2G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_74249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2G9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="767" mass="84799" checksum="AAAEC3E8BDF5A4FD" modified="2024-05-29" version="1">MTSVEAPATSHSGAVSRSGSEDARLAVASEGGSNGGVVARDNSLHVESAGSTRTGDPQDSSYVASFLSRQHLMPHWRNVLARPRNRSCGSVTVLSFSSSSSSSQSGGLTLQSSHELSSYAVNPSSLTAALTPDLNAGLEQADSNVLSSLPRAVLVSDLSEPLINSLGPIFRLSPETFEEHLIRSGYTSTSYQDRDSSTWPTRFLPKQHVSLRWHSLVSRKDTEPRDASSRRVLMEDMMEWRRSFGKGPGGKIMWHTRLLSKLTNIFRQEWSLSPTSRPLKRRLVMSDQPRGLIDIGEGDEFEEVEKGPRADEELDVVAWEERVTFCWGSWNQGRCPILFFDPLPRMLLNDRQVHQESKWVNFVPFSKRLAPRGPPPAQEFDHAPAALDAVSAYANSTSDALSDAAAWVRHLTGESAFKDNGSSAVDLLLFAVFQVVRRDTIALLGHVGDVLDQISSGSMDERMMQEQLEHWRAVLSRLQRELPVLEKSMGDFFMFPYYAESKHGEASPPPPPLLNAALRELQADTAAMTVRCQKVQESLRAEMSLLESKRGIQEAESVSRLTELAFIFIPMTFAAGLFSMQIRELADNPPPAYGFVIAAAVAVALSYGLRLVQRSTVVSESLNKWEDEIRRDEQVMTRVIPIRKIAHWLMLKLRLKLLIFFVSSGSIAILVAPLWTRTAMDTSFKVVITVLALLCMLLVVGMVLWVSTSAFESLIPNRGNTVLGFGRIWRGPPRVREWETGVNPNGPNLADDNVTAGQQGNSADDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3W5</accession>
    <name>A0AAE0N3W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_76736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="470" mass="50761" checksum="52C81A26D6B38C2F" modified="2024-05-29" version="1">MGNSNSALSQCLGGVANGRSGFVSYPENPLYQISWVKRYNLDVHVTPAAVVRPDTSQDIADIIKCATANKVKVQAKSGGHSYANFGLGGDDGAVAIDLVNLQEYRMDPTTWYATVGAGFRLGEVDKRLHETGRAFSHGVCPDVGIGGHATIGGLGPMSRMWGSCLDHIVEVEVVTADGKIQRASETENSDLFWALRGAGGSFGVITKFVMRTHPEPANVVQYSYTAKFGKQADMAAFFSSWQDLIANPNLDPRFGTLYMMMPLGAIINGVFYGTQEEFEATGIPASLPNGKDQLEASDWLGSIAHGAETEALALSNIASPFYSKSLGFKRSDLIPPAGIKQLFEWIDQQDKGTLLWALVFDAQGGATSAVAPNATAYNHRDKIMFYESFAVGFPLQGKTKQFLTNLHNKILQLAGPGAYGTYAGYVDLALGTDAQNQYWGANLPQLQNIKVKWDPTDVFHNLQSVQPIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3Z6</accession>
    <name>A0AAE0N3Z6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_402397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3Z6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3369927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="78" mass="9305" checksum="9601D04A2A3F4786" modified="2024-05-29" version="1" fragment="single">PTEATREEMRDAKVPLAYRDSCANLLIPLNRCRFETYYLPWKCQDERHSYEKCQYVEFKKRVAKMDELRAAKDGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4M2</accession>
    <name>A0AAE0N4M2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_318558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4M2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="539"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="618" mass="67638" checksum="A0CBD6F51EBA4A4C" modified="2024-05-29" version="1">MGISNRLPDGLDEVDIIIAGGGSAGCIVAARLASADPSLSILLIEGGTNNWNVPNVVHPALFGEHLLPASKTAIFYQGNQSLHLANRKPIVPAGGILGGGSSINVMLYSRAQRPDFDSWKTPGWSADEILPFLKKLETYHGHGKPEHHGFHGPIHISDAGFRVKNVEEDCLRAAQSLGYPEIQDLQNLDDTNGFERAYQYVSLDGRRQDAAHTFLHPLLQSGKHSNLHVLTEHKVVRVLFDDNKQASGVEFTPNPDYQIATPLSQHQKKSVKARKLVVLSSGACGSPLILERSGVGSKEVLDKAGVPLVEDLPGVGSSYQDHHLTFIPYLTSLEPHETSDSIMSGRVSIREALKTIPKQVGWNTIDVAGKLRPTEAEVAALGPEFKAAWDKDFRDQPGRPMMLMAFINAYIGDPTSVPVGQYMTFASYTAYPYSRGHIHITGPEISDPIDFDVGFFADEGEIDLKQHMWAYKKGREITRRTKFYRGEVPHGHPRYPEGSKAACVKLDAPLEGEIKDVEYSPEDDAAIEQHLREVVNTTWHSLGTNKMAPREKMGVVDKDLNVYGVKGLKIVDLSIPPENVAANTNNTALVIGEKGADIIARELGLSLPLSGELVYENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4Q1</accession>
    <name>A0AAE0N4Q1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Aurora kinase</fullName>
            <ecNumber evidence="2 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_497516</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 16"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="118"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3370676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="379" mass="42737" checksum="94576441578353A7" modified="2024-05-29" version="1">MSTLDLEAQLEHLSIKGEEAEMAPKSATPLLLEATTISTSSNSTASRPGHFLKVALQNHTRIASATASPRLPASSSYKILPVKAESEEPPPERAQQRHKPDNTLVRQPSVVVAKKKFHLGMFEIGKGKFGRVYLAREREHKFICALKVQVRREVEIQSNLRHPNILKMYRHFHDAKRTFLVLEFTGQGNLYRHLRKALGGRFPEWMAAQCVAQMASALRYLHRKHVIHRDIKPENILVGIHGEIKMSDFGWSVQAPGGNRRTHCGTLDHLPPEMVRSSDLNNSYDEKLDLWSLDVLTCEFLVGEPPFEDSPIMTTRRIARADMTPVPAFISAEAKDLIQGRLPLEQVERHPWIVENCVNKRKICSGPGHERKIADAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4W1</accession>
    <name>A0AAE0N4W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_440744</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="78"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="593"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3370350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="784" mass="84229" checksum="4A5316E33F3B7E02" modified="2024-05-29" version="1">MILPARRSLAVAAGRACRQALLVPRTSRMPHTPVCRVRAATYSTTPIYRQNTFHAQLEASPSTLPKVAPELPQTLTEKIVQRYSVNLAPGKKVKAGDYVTLSPHHCMTHDNSWPVAMKFMSIGASKIHDNKQIVMTLDHDVQNKTESNLKKYQQIEEFAKKHGVDFYPAGRGIGHQIMVEEGYAWPGTVSVASDSHSNMYGGVGCLGTPMVRTDAASIWATGRTWWQIPPIAKVTLTGLLPLGVTGKDVIVALCGLFNNDDVLNHAIEFTGTEETMRTLPVDDRLAIANMTTEWGALSGLFPIDSVLQSWLRAKATVAAMSNADDSARNQFTHAKIDELIQNQLTADPGATYAKSLYLNLSTLSPFVAGPNSVKIATPLKDLEAQNIKLNKAYLVSCTNSRASDIAAAAQVFKDAATDGVIPKVADDVKFYIAAASLLEQATAEETGDWQVLLDAGAEALPSGCGPCIGLGTGLLEPGEVGISASNRNFKGRMGSTEAKAYLASPEVVAASALQGKIAGPGWYQKPEGVEKVIIGEGNGDHVHDKAISIEEALDKLLAEAEDMIAAAEKSMLAESAAPAAAPEEAASTEETLTEILPGFPEKVEGEIVFCDADNINTDGIYPGKYTYQDNVTVEKMAEVCMENYDKSFGTVAQAGDILVSGFNFGCGSSREQAATAILAKKIPLVVAGSFGNIFSRNSINNALMGVEVPRLVQRLRETFGKDKALTKRTGWTFVWDVRRSKVTVTEGNGGATWSQKVGELPPNVQEIIARGGLEKWVKHQIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6D7</accession>
    <name>A0AAE0N6D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FluG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_283715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3371955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="791" mass="91256" checksum="5892C2212B70FB1D" modified="2024-05-29" version="1">MPARTEAVRHHTARNGVLGHHADFLKRVADRETNARVSKQPPPLSVKQHAAHRKKMTGVRFIKPKYAAETQINVSGIYGKWKRYCTDMEVGEWETILKKVNIATMEDFFLWVCEKHKIRSWGTSLEYIRQFQQLYTTVTGQYTDRNNNKELYKYHDRVLIPRFGLRAPNIDGKPVLNVDALRVILTFNIAYDTGVVPLERQRVNQAGCDMIICYAGVRPAELVNNERKPPKDGSLDELFGAKAVMSAEAQSDNEGTEDNVATDEDMKVVETLLLQETVGRDRQKALCYEDILMMIVRHPATGQATLAMSIKFVHHKGCDNKPRPTIFFFTPSKKLIFCPILLFLALALSDHAFEAKCIDDARSVLAAQVPGGLLCVPLRWKESMLKIPFFRRVSRDGALSENEAMLYATLRDHMARQSLEAGFGVAWTPKAGRRGAANAANGNAPDAVRDQMMRHNPKFFTFFSAYLNQIANFHLQNAFLEEELENQLFRMFAHVSLTRDPRATRDMVPEEVWASLPPDPEISKLEERRAELKQGQYRFDGHKDEDEIRELTYKIRLKLSQREKRIVKEYREYYFYHRPTWDLERQAEGGEVEQYEELAIDLVIPERARLAEIFCHQPDDLGDKEMAQLRIEVINLYVALCGKRETVKRKRAQRTAPAKLPTSGFIKLEADPDIEFKPAPGPFPLLTHPNQCPGCIGDERMSLKERTFRYCRPTKRNDHFDDNHLEAKERAEQLGQLIIYNDKRCKDMTLYTVDHFRNHVQSVHTITLRTSEQVQERRARKLKLRRSRQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6H9</accession>
    <name>A0AAE0N6H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_401077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="529" mass="58421" checksum="81BB3DFF9DD2FD49" modified="2024-05-29" version="1">MTSPVAITTALVVVIGLLLNYFVPATIDAREPPVVKSRIPLIGHIIGIIRHQANYHLILRRASNKPIATLPMLNGKMYAIWDPSLVSAGLRNKNLSNTAQIKEVVKPLFQVSLAGQEILLGPKGGEIVDRILLNVIPPAFKGTNLENFSGTALSLIASQLTSLATSETTSVPNVWLWIRGLVTLATSPALFGKHDPFSKAQLEGVDLEQSMFDFVTSIFLLVVNVLPSIIAPSGNRARAALLRELIPYYSSHYDAHETASAFVKNRAAELRRYGLPDEDIARTEIMLPFAALANTVPTLFWFFSFVMSRPDDLVPQLREEVNRLIVGRNNGEVTLNVSQAAIEEKCPLLTSCYKETLRMTVRQVSTRTVDQDTTLTDARGTHTYLLKKDAVVQMALGVMHTSKEFWGDDVDEFNPRRFLAFNTNHPRDDIEKDGPGSLKAMRSAFQPWGGGMHLCPGRQFAYAEMMALMTTMLLGFDVEPLDGGKWQLPGYATSSLIDAVTKPAKEGKGFGVRIKKRTGLEGVSWKYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6M5</accession>
    <name>A0AAE0N6M5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_484075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6M5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="83" mass="9566" checksum="4E6523539C545AAC" modified="2024-05-29" version="1" fragment="single">MSILKWPIFLIICFDRLSSLFMLALSAGMADSTRAWPRRFVSNWLLKLLCHHGPHQVLYYPRITGIWLAPKNANWPRSAMAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6S6</accession>
    <name>A0AAE0N6S6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rpp20 subunit of nuclear RNase MRP and P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_290681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6S6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="217" mass="23288" checksum="2348C3FF6457DD3C" modified="2024-05-29" version="1">MNPSVPVALPNRPKNKLPPLPKGARIQKRPLAGPSVTRRLNKSRGNLLRGDRVLPDVDGYNAPPRASHTVVIKIGTHTPFMAVVKRVRKALENGPQTTKGLPLTARIAALGVKRDNNSTSATAAQQPSSSGSVSGSGGFIEDALDDVVLIATGRAISRAVEIGAFFMREKELIVLPRTRTIPAIDDVVMSDEDGEHEDQVRVRNLSCIEVGIRWAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7L6</accession>
    <name>A0AAE0N7L6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_294990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7L6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3372419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="143" mass="15099" checksum="B95F3D15682790F4" modified="2024-05-29" version="1">MADATPHQRPYRGRGGGHRGGGGHRGGRGGGRGGHGGSGGDSQTPAERPKKENILDLTKYLDARIHVQFNGERQVTGVLKGFDALMNLVLVDVEEIIVDEDGEERTRPLGLVVVRGTLLVVISPVDGSAPIANPFAPAEMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N970</accession>
    <name>A0AAE0N970_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_480828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N970"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="433" mass="46797" checksum="9E409673ADB444AB" modified="2024-05-29" version="1">MSPSPLAIQVINKTDHTEQHVVTLPEDAAPAPLTTGSNSVRILSRTIALTTNNFSYAMLGGIPMLGWWNVWPMPASLPQPFNDASKYCRISAWGWSEVVESTISDLPVGARLYGYQPIGTLPETLELTAGDVPGHWFEVSNFRKPLMPVYNRYYEANANDKEMTRTSLGYDALMRTLFETGFALNKFVFAWPSSTTTTDSSKIVAPIHPLGQPPWSQADADVTGATIIMLAASGKTALSLAYLLRQGRPTEAQPKRIVAVGSDKSRGFTANTKFFDKVLIYDDVTSASVLDQITGDKPNKIVLLNFGARGDAAPKWMHALKTHSPETRVQVFIVGGEPVAGARGGNELMALAQDPTSDVRQVNMGGIRAKAMADVGAVEYFAHADASWNDFKQGGGIPELELKSGQGLDAFSKGWDALVKGEAGADTGLIYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBU5</accession>
    <name>A0AAE0NBU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_547606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBU5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="298" mass="31873" checksum="F7B3BABF3BB21866" modified="2024-05-29" version="1">MSVLLPVPGSDMSATYDYLTQTLTVEAKGTIQGWFAGAFVKKDIWFGGLRYSIRGFSNGVPPIEVPDFTTIDAKYKDHIHLPLDHFNSKNVTVETGLGTFYVEIVYLMLGVGPVKTHPTNGYKTAAAAATTTEGEEPSAVVATNGTSTIDEPAVTATTTTSSDNADTAVGGKLIKDDSIVTDVLPPIHQNLLAPPSTLQISSPIPVTIALPEIKAYIDISFNPVFFRLLDTRYAAGSIIWTVGWAKLPLGLGENPQPIDVITTVVNQADPKNISTSRNVQSYFINFVVLAGAATEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC73</accession>
    <name>A0AAE0NC73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_245290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC73"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="53759" checksum="94F0B24C3B54E735" modified="2024-05-29" version="1">MCRFLVYKGSDEILLSKLILDPTHSILKQSFDSRLRLDTRRGQNNADGFGIGFYTDPKLGAAPCLFTSTTPAWNCVNLQRLASKTASHLIFAHVRATTEGSLSEDNCHPFCHGSLMWMHNGGLGGWKQIKRRLGERLADKWYLGVGGGTDSEWAFALFLDTLERMGHDPSSQPEHGFGPTVLRKAMLKTIALINELIDSIPESILHAENVDTRSLLNFAVTDGHTVICTRYVGSASDEAASLYYSSGTLWETRAPELENRDYQMERSDKGADVVLVASEPLTFERENWVNVPTNSILTIHNQTVMVHPIMDQYYDRNPHHRRSAAFVRTKGLAANEKTSSRAGTPLPVPLTVGDNHNQLDVASLASQKKFLGPTIPFSVTSNSGNVPRARTSLSHCEVAAPTTLPQQAQSSAAQPDHRSLRSAPQQQQLQPSQGNIKKKRASLTTVEAAYAAANPLLHHDASPVSPEPARTEFGNPAKLAQYFPELTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGU5</accession>
    <name>A0AAE0NGU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_416017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGU5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3381268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="623" mass="69092" checksum="94743A1DF583E165" modified="2024-05-29" version="1">MASHDLRDVLNLPSDNSQGPRPSKKQKTHAPRPNLKGLAREVQNLGGDNPIAIVPDVAVFKKRRLISRKPAAPWVHKPFTNSARGDGGALVLRHWRRKTVEDAPPDLMQEDGEPRPGAAANGERRTDQTDEPEDSSFAKYNVRVAVPQYSEDQYHVNLQSNDWTKEETDYLLELAQDYDLRWAIIWDRYDFSPRPPQGEGIDGAGVAVVPAPKVRTMEDLKVRYYEVAAKMMAVQKPVQYMTDAEARLYEIMKKFDAPQERARKEFAINTMARSLEEARDEEMLLLEMKRILARTDRFNEERRELYHRLDFPATDSDINQFKTSTGLQSLLQNLMNVDKTKKRKSIMPGEGVSPAVPVPGSAVSEAPPGRRESIAASIPGGHRDSIAGTPATPAEPTPKDTKKKGAHQPERRKLTEQEEQVYGVSHHDRLGSGPTFRYEKINKLYSHKSGQQQLRITNALAELDIPARLVMPTAAVTGQFESLWAAVTALVDLRKVSDRLDADIRIEEAKRAERDKARGITSGGKTESRGEPGRVAESEGADAQRSQQNEPQNGDNGDGESSPAAPNPRASVEDASDNKPPPVSEVKQEPSGVGPRPSSSGAHKRSASVLSTTSDKSTKRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH36</accession>
    <name>A0AAE0NH36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_395738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH36"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="124"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="565" mass="62596" checksum="C5F4342B1CFC53D1" modified="2024-05-29" version="1">MEEKLEAARHSEISERGPYEEDLSISREKSQEDQESGGGFVPIRTTAAAPPSSRRLSKDTAASLRRERSNNGWGVDDLEADADSDAPSSSADVEGEHDPFEVGWDGDNDPLNPRNLPIWRKWVIIGVTSFGSFCVTNASAIYTATYTQMNAEFGSSRLVATIGLSTFVLGIALGPFWSPLAEFYGRRPIYLCSFAAFVMWLIPSAVAKNIETMIVVRFFQGLAGSAFLSVSGGTVGDLFTRDTMLAPMAIFALAPFIGPATGPLMGGLINTYTYWRWTHYFLLIWSFSLLVGVALFVPETYHPVLLKRKAHRIRKETGDERWKAPMEKSSRSVTKTVAYSLLRPFQILISEPMCLILDIYSAILLGMLYLFFGAFPLIFKNNHGFNLWQVGLTFMGLLVAMISAVLSTPIWRRVREGLAEKRRKETGEARSEPEDQLPPVIFAAPLITGGLFLFGFTTYPDIHWIVPIIGSAVFGLGTMLAFSGIFTFLVDAYPKYAASALAGNALVRCSFAAAFPLFGIQMYEKLGYQWATGLLAFITLALLPFPYIFFVYGKRLRARSRFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH86</accession>
    <name>A0AAE0NH86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_450823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH86"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="50981" checksum="A3ADCDA7774554E3" modified="2024-05-29" version="1">MNGILELRLKAWYYTDPAKHAKHTGLLAKYIQKKLPAKQGWAVTPASDSIAGANGNIHGELSLFLPMEIIFTTNKTGSKREYDSDGNVRVHVEIFERLFRFLVPFMGQTKLRCILGAENIKALCWSLGSTQTPYSNKLSRWMLLAPGEPIKFPAERIEQVLYNLVQISIRRSDNSHGPCGGGGVLECIENQLFKQKQTYDLLNDRMVKLPEEKGRFSQDSTYQDDQLAYIQDNIRAIERVDRDINTIVTLIEKHVGRSPPPQGRWKIVRAIKGLFQPKFGAIAVDDAAIEQLKKDVRRELNLFQCISPVMAAHIRLCHASNWYFLPPPFFSEQLKRVCDSASEGPEKREMTEKMAISPTSIGSDAAFDKVRTHYDEAYNKLLAEIEALNKALGVEYVRQGAALFRSQSVRRSGCLIEAQAQGLVLGKKITLWSSGSRYRGTSTEVTTTSPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNJ1</accession>
    <name>A0AAE0NNJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_171385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNJ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3384806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="527" mass="56121" checksum="9DF15069DB6E0D79" modified="2024-05-29" version="1">MDQPDDSSAKSLPGTTNANSSGSSLGVTAPSPPELSNSQSSQHKSAHVGSHRQSFAENQRHPPPSPRSQRHPSFTQQAIQELLNHPPTNRHPNPRFVGRDWRDISLGELAPDEARWAELDTSIEDATMALLKGNPSNVVLVRESSESKTAISTFDHNDLNAYLLVVVGLAKPDEEHVQLYDEIAKKAQAQTAITLLEIQRICRKEELVTLSAESTLDKAMEAFGSGIHRLLVTNQAGEVAGVLSQLRLLEFFWNEAVNFPVIDRLYGSLLRDLQIGTQQIIAINADAPLADALLLMSNEGLTSVAVVDHGLNVVGNISTADVRLLTSAASLPLLKSSCMHFVSVILTERGVERGRDSFPVFYVNPYSTLAHTVAKLVATNSHRMWVVESASPSPSAPTTPLLQPSHPVVTPAAAPMASSGSVVGAGGTPTPPPTVVIPSSTSATSVTQAPLPSPGFVSVPSSSLPGSGISGRLTGVVSLTDVLNLFARSSGLHPSDPSEQRARRRRSSSSSVRPTIEGGRASLDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNV0</accession>
    <name>A0AAE0NNV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_394338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNV0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="440" mass="47888" checksum="6BD7DE03E3ABA6B3" modified="2024-05-29" version="1">MCEPPTEKSVGAVLNPVLASGVTVWKVEAVPSFGLQRVYGVALSDGKAPLMLWLPPPSMLRLLRSEQMMVASAAAAVRWIRKTQTVVLAASTTTTTTTTTPSSSSSSATPADLLPFLPTLIHFSPDRINALGSAFYFFAPTCGNPLAVTPSVLTPPERRKIDLQIGWLLRRLAQLTSPSGRFGPVVAVMAPASPLHYHRQLPGVGSSSGGLMGTSGTGTWTMAFHSMLEGILRDGEDMAVTIAYSAIRRHFHRLSYFLDAITVPRLVVVDGAEEANTLVTDRSEENSESGVGEDQAPSYEVSGIRDWSSCIFGDPLFATVFSSQPSEGFLEGFNGSKIEEGASRPGISLSRDLIQDVESAEVRLLLYQAYHATVSIVKEFYRPRVDSSKRELEARRRLNEVLARLADVQDDPKKRHQRPSGEMSPAKRIKQDEEMKDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP79</accession>
    <name>A0AAE0NP79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_472472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3385172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="500" mass="56022" checksum="379614A25BBDB290" modified="2024-05-29" version="1">MPTIMSNVLSTNVTPASLLTLVLVAVVSVAIKRRYFSPLSHIPGPFLASVTRLWQVATLIQGDSIGVFHKLHQKHGPFVRVAPNEVSVCHRDGPRKILLTALPKDSWYRAGALPDYRFQTTLSITDPKVKVARAKQFMQGYSTSTLLTFEHRIDKLYTQLFTWIDKFAADNKPMDLDQFFSFTAADITGELLFSKPFGFLEKGYDIDKTLSRSHAIVGIGTTAGYFPWLSKLVANPFVTWTGVLPFRLVFVTAMDAIAERHARKVDTNDNDPDILTLWLQALADGKVTLRDVQGQTTLGIVAGTDAMSTGLQTFVYHTMRHPTAWQRCRDEVAALERAKGRSLAKIVSFADAQEMPYLQACIKEALRLFGPLGTGLPRVVPEGGTTIGDMAFPGGTTVSIHPYSMMRDKNFWGPDAETFNPDRWLKKDSAELDRFYMPFGLGYSGCPGINLAKIQMSKMAASLLRDYDIRQVNPKQEWTYEAYFNTLPHDWPVYVKKVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQP1</accession>
    <name>A0AAE0NQP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_449950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQP1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35063" checksum="121B8361E7C7E02F" modified="2024-05-29" version="1">MTPPISRKPFHPPGRLPGCRTAPNQYLCALPSKRFHDGHKRNVSSRVCLFHNVGPNSHLGKDLSTAEGQEWKTRREVIASCFNEPNNEVFEGHTERSDTSTSANYKSSVQMILENCVLIMALGRGQLPRLKCCLAIMLEMIRLYTAVPVSKWVGGDQTVTLRVGCGKTTIVLPPKTMFITSYAALQTDPKYWGPDALVWRPSRWIQERRPGQAKPGDETLITIKKSAFLGWKFSQVEFVATLAALFRDWRVDPAPLHDGESRKAARKRVLDLIEHDWLRCSCCRFCIPKGRLWFGGREIDHVWNWTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRF5</accession>
    <name>A0AAE0NRF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_192386</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRF5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042108030" description="chitinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3386130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="373" mass="40776" checksum="D0152416DEBCB5B4" modified="2024-05-29" version="1">MKRGLLSAAFRLFTSLAAAVPAKTLVPDVSPELPRLVLYYQTTHDSAGRPISMLPLVTEKNIALTHLIVCSFHINLNGIIHLNDFPPGDPLFYTLWNETLVMKAAGVKVMGMVGGAAPGSFSAQTLDGDDTTFEIFYDQLYDAISYYGLDGMDLDVEQPMTQAGITRLIKRLRADFGPDFIITLAPVASALRNGANLSGFNYKTLETAVGNDIAFHNAQFYNGFGNMASTADYDRVISQGWNPSKILAGQITTPSNGGGWVPYDRLNATIAALRSKYGQIGGIMGWEYFNSQPGGLAQPWQWAQVITAILRPNQVPRLKITKDKAEKLVDTWKYSRKPTGKDSGNPRKSKGDFITGIVHDTAPNVDYMAMINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS48</accession>
    <name>A0AAE0NS48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS48"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041972883" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="228" mass="23621" checksum="E9B528F102D9BD0C" modified="2024-05-29" version="1">MLSKLFLSAAVFGLASAYPKCSAPLPTTTAAISPSSSATTPPPSSITTAPQLICTGGSTIKTTSDCTYPSITYSYCYSAPPPLTCSEGFWPGHISYGHCMDGEICYKLNETWITTTCAPNGQTAYTTNTLFSGTLAGGVSTVISAVQCACGANQWYSWGPTDGPQSVYCMPQTDCPSGMTTSWSTNTYCATVTTPSYCSTDKVTTPYCACATGLPQYPAGGGAPTTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD3</accession>
    <name>A0AAE0NSD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_558304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="405" mass="44938" checksum="500DB206F53AC2F3" modified="2024-05-29" version="1">MPPKKNATEAPANNCVAFGRVRSNLKMGCVGLPNVGKSSLFNLMTEQSAAAENYPFCTIEPNEARCVVPDARYDFLCKVWNPPSQYPAFLQVTDIAGLIKGASEGAGLGNAFLSHIQAVDGMYHVVRAFDNDQVLHVDDSVDPVRDLNTIQSELCKKDLDFLKKAIIAEELLVRKAGGKFKMLPLFYETTAKIQALLEADKPVRDGEWTSAEIELINEKLSLITTKPVIYLVNLTMKDYLRQKCKYLGKVAEWVKAHGGTAADIIPFSVEFEEKLWAMRDDKAVQEAYLAEVKVPSKLGKITTEGFTRLGLQYYFTAGEKEIRCWPIKKGTLAPQAAGVIHGDFERGFIKGEIVAYQDFHDLCGGAKSMAPIKAAGKYRMEGKGYEVQDGDICHWQFNVAPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSM8</accession>
    <name>A0AAE0NSM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_412106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="751" mass="82416" checksum="4CCA2BB9D4BC3670" modified="2024-05-29" version="1">MFSEYASRFLAQSQSRLSNFGQPDNGADRTSRQPADWQSRGGRLGRQPYLGRGAANPYQPGAGSRFGSLATFGSRYASQDAPLFQAALEHEEEDEEERDREAADLFALQRSRRVFAAAGRLDESTETENDDSRISVEHSQEYGEDTLGERIRGIRSSWNGPKTFSRRGQEQQGTRKELDEQRRQGSSESDESRGRMVDVGLESIIDSEPPADLTMETPVDDSTPPAFQKFRSSAAPTRYPLRRESTNDSELGRHPPPSSVDTNANELVTPRPVSDGEMFKHDSFFAWIYLIAQASLFATFVLVFLHTSGNITRGDTIYSTLRASFHLLAVDTLVSVIVSVVWLAALRSFLRPLVALILIAVPVILVSFSLYPFISSYDSDTRSSPLQDMLMRWAATIPAISAVLWLYLVFKGRHALKSAIEILEFSTRILTANSLLVLVGMACLGVVVLWTWVWLLMFTRVFLGGSMSSRLSGFIISASSWWLGIYFVLMYIWTLSVISGIQRATTAATVSQWYFHRNAVPPTSPRQIVSAAMGHSVTTIFGTISLSTLLALAIRLPLLILPQRAANLISMFAYSFIPTPIAALTNPLTLTYAAIHSTTLAVSARGLSQMDFLSPQRPTTTLTPAALSAGNNRYSPLLPYRLAKLILHATRFIMATALGFAGWVMTAHQLSVDGSLGLKGSAYAYVVGLVASFIGWGILGAMEGILSGIVDAIIICYGSETRMASGGGGYCMEAAALFGDRRVGMERDELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSY2</accession>
    <name>A0AAE0NSY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_149519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSY2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002308">
        <property type="entry name" value="Similar to Rho-like small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="191" mass="21465" checksum="3798FCA033AE6740" modified="2024-05-29" version="1">MEAHTVTILFLGDDGCGKSTFLSRISQGRHKLGGRAQITLLRDLDQPFVFEVRARKGLYRFEFYDTSSPETWKLLKPDLIVVCYSISQRLSLINLQRVWIKEVRTTFASGDAIPLLVLGLKRDLRSEDDPNGIIYPQEAYQVAQDMRADKYMECSAVTGELLTEVFDDICNTAVRTSTEAGGQSEDGCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT52</accession>
    <name>A0AAE0NT52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSF-type DNA-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_521225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT52"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="578" mass="64109" checksum="50F71C45F01033D3" modified="2024-05-29" version="1">MAAATESVPRNHLVEGPDEPMGVRTVPIITPTIQMSVPSPGEPMEITTPTNSSAPASATKSPDSDVNANGYGERPQSAMQNDQLPMDNIIMPAPVAAAAAVHQPKIVQTAFIHKLYNMLEDKTIQHLISWTPTSESFVMQPSHEFSKVLAQYFKHTNISSFVRQLNMYGFHKVSDVFHHGAPDATLWEFKHGNGNFKRGDLVGLREIKRRASRHALVHREYNNQKPPPSQPGTPAEPMPPMQEGGDPRLHSIEHTLFDLNNRLQRTEENAQFMHIKHQAIMDTVSRLLQFNHDLSRAVLALAPSPDNPIHRDVSSLQGDVQRQMEMFRSLEEHHEPLFASSRPYFSNLENAPVSPRQLPQDDPRRSNLAVPQSRQSNYYRPSIPSSLSVSTRRPYGSIGGSTTQSSPSSLRSQPPPPPPGPHPLANVELPPNLARRHTSADIRAHGWQPNNPPLFASGPPSSQWPSSPSRVAASDDQRLRDSLSHYSLQAASQPHSRPTTPPPPPFANGGSGPDFGNWSWNSTNRGDNKNLAIKDSSLPPTRRGSMAHILNPTDTAERDDEDEMDPRGDDDRKRKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTX8</accession>
    <name>A0AAE0NTX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apc15p protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_470653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTX8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="403" mass="43353" checksum="8C545855F1B53F21" modified="2024-05-29" version="1">MFSMLPDLTPRDSHSLWYTSSRNPNSNPSHLDISASSSSAGQGHENGGHTSNRGNNGTTTDPRSAQGSNLHQHHGGGSSAGVIERSVLGRLRADEIYMERRRANVGNMGSTWLKPPGVSKTLFQLREERREAEEHAEAIRREMLAQELAEAEAAEAGNAVGPDGAMVLPDADGDEQMLEDEDDMRDLDEDIPDADEEGGFGFDGASDDGEEEEEEESVGEEEDEEEEMAPEQREMASIRATEDRHRERLARGGGGGQGGGAGDLYGADEDIDEEDQAHMLEEDDLAAAVYPNEVGPGEDMDMEANLDDDIPEAVDESGMGYEHTDSEASLSSSEDDGNNHNVSYASTAVRARHQVSSVHRQRSSMAGRSGGNGAPRSSLDISSILSRDGSSVIGSSPQVRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTY4</accession>
    <name>A0AAE0NTY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_163644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTY4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041931548" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12436" checksum="93B323CB8DB03980" modified="2024-05-29" version="1">MAFWLAWLGEWSSFFLLCPFGASCCAEEANKLRVTVNHGFLFLTCLDFLFIAFVLLTGCSGLALCPCARNKPEGNEREVLTIIISVDQVSVYSMAANRRRKQHYSLFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTZ0</accession>
    <name>A0AAE0NTZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_493802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="352" mass="39995" checksum="0BCD74CC36329479" modified="2024-05-29" version="1">MALIVDKHRPRSLDTLTYHEELSERLRSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELFGPGVEKIKIDARVFQTSSNRKLEFNIVASIYHLEITPSDVGNYDRVVIQDLLKEVAQTQQVDQSARQKFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTANIIAPIRSRTLLVRVAAPTHQEICDVLAVSAKKEDWPLVKGLHQRIAEESGRNLRKALLMYEAVHAQNEKVTDTTPIPPPDWEALIGQIAREIMEEHTPARILQVRSKLYDLLTHCIPPTTILKTLTFKLIPLIDDALKADVIKWSAFYEHRIKTGTKVIFHLEAFVAKFMRILEMYLMSMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTZ7</accession>
    <name>A0AAE0NTZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vesicle transport V-SNARE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_163614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTZ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3387692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="26195" checksum="782E12EAF0002387" modified="2024-05-29" version="1">MSHNPLDTEAGTELFSSYEAEYKLVQADLTQKLDSIPDLSGEPRKAALTSAERALEEASELLDQMRLEKQNIPSSARTRVNQRLRNYDTDVDGYKRKLRALADNRAALFSGGRYSDHPSGGDGGPGGSGDVQLEQRQQLLSGTDRLDRSTQRLRASQALANETEAIGASTLADLHRQRETIQHTTDIMLESEGYVDRSVKTLRGMARRMATNRVITIAIITILVLLIFAVIYSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXH9</accession>
    <name>A0AAE0NXH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_427827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXH9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="606" mass="65185" checksum="2BF67597E584AD98" modified="2024-05-29" version="1">MALESEGQRPAKLRADDLLGDKNGQTGSDSETISARPGSQLDDGNEKIGPEAVPEPEPAVDSADPTPPPPLQEYLHGAKLYVLLSAIIVPYFLMTLDQTILATVSGALAIPYITDEFHSLLDVGWYASAFQISNAALQPLTGKVYSRMNIKWTFLSFFLIFEIGSAVCGAAQSSIMLIIGRAIAGLGSSGLMNGALTILANAVPPQKQPGYIGLSLAIAQLGIVAGPLVGGALTEYASWRWCFYINLPLAVCVVPVFLLMHIPEQVAKPKWTTVLKRPFQEFDLVGFALFAPAAIMFFLALQYGGNQFAWGSATVIGLFVGAGATFGVWIGWDVYRGEDAMVPISVLRNRRVWASCSMWLFLCGTLFIPAYYLPIYFQTVLDATPLMSGVYILPIILPQMFFSILSSKAVERTGYYMPYIIFGGVVNCIGVGLTSTLDPDSSKGKWVGYEILMGVARGVSVPMAILAIQNAVPKKFIPVAMSIFVFCQTFGAAVMIVFAQTIFTNSLRNLIIDYAPSVDADFVINIGAHAVRGVLSPGDLVGVLWAYTGSLARIYYLAVGCAVASLAFAPFMGWVDVRKHEDTGDKKPVKAEKGGDEPSASVKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXT3</accession>
    <name>A0AAE0NXT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_464006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXT3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32856" checksum="2DFA8AFC9ECEF993" modified="2024-05-29" version="1">METSGDTTTSPMGFEAALVLSPEDATLGIHNDGRVNRLLATQEHIGRTSFSAYLRHVQYGTYQSRPACLLAVDISFRFPAKSSSRFSSAEVDITFEKALNRNKPSQRCTDASLDPVVTNFAPKAMLGQVRERENRKTLELEVPLTFEAPFGSAEFAARWSREMTMTEEGRAELHGNLAQDDEHDDGANSVVWDLTENPVSKEGILRSFRAVAVLYLRRRGEAFWMRVDVKPVVKFSLDPSRLFTKRLVREGDEPILLDGETVLGESSCHGHEVFDAADFPWETVLNLPGPLGGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY85</accession>
    <name>A0AAE0NY85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrate assimilation regulatory protein nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_104581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="662" mass="73719" checksum="374F5714AF3B1A02" modified="2024-05-29" version="1">MPAMRLGGQTRTACERCRKKRAKCDGKPTCQKCEESGHLCEYDLHTRRETKSDLRESTQRLRKSSVETEEVLKTIASIEDPNICKAVLQGLVDGNTSRQDILEGNFKLEDVDINIKQDSHTPQLDSDLPLFKNPEAPLASQQCFGQLLSWRLCRPPPPPTDAYIAAKTPPTVLSLPLIPLDAHSPPLQPHVDTWTRTGWTRAHIRHLVDALLTWDFLPFCLFSKDLFLQDYHTESTQFCSAGLVHAVLALATRLINEADDDDAGLLPSGWLGSNLFFDAAAAMVLDTGPVHSLPDIQAVGVLALYHIRCGREAEAQKLTEIFVSRITVLCQRDAPFAGNGEDEQYARSRATTYCGAITLARMLSMATGQLFNNPHDATHSELLCLDQTFQSSEDHKSERSAVKAYNTQLLQAITTKIYQLTEWVYNIIVSAQSDTGTGTDTAPRAMVSVYTQCLGWYEEFFALLQSNGSRTPLLLFVHMYYHFCLFCAFRPFISLYSLPDSDIRPQEICTQAAQSILALAQSYDDLFTLRRVSGAMPYFVCASGLFNLALEDSGNSSVDSLDRHRRHQSSQQSSVRGDDEDSPMTNYSYGTKSEPPEQQFRDMSVSSEATNTTSQSPLKTSAARHAQLLLAKMGSTHPAARIASRVLRDMIGMKREKGEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYM7</accession>
    <name>A0AAE0NYM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_464706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYM7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="491" mass="55030" checksum="E463D3D731D2F104" modified="2024-05-29" version="1">MESTAATTYQPPSRQKNCSCCVQAKRRCDRKTPICSRCADKQLPCIYAPKYTKVASQHVSATTSSEDAPPFDSPAYSSLFSPGQLSFDFDGFLGILPPDTHSARPHATVDELTITADVSMDDAAAFMHMVDNNATSTSPFHDMDVDRQWLVSRATSTDNPPPRPSTPADDEIARSYKKMEPFCHHFEPWHLYDPKSTLHYVTNRVKSFTNDMATRNATPFLHRYLYRDYTPQCILSCFATSVLYTSRTPANTAMVMQAIYTSVRELVDGGQSDEAASGHHNKFLAGPTVTPVEKLARVQALFLYQAIRLFDGDVGLRAQAEKDMALLQTWVGELCDLRENLGDLARSGEDISAALRAQPPKDWERWIFAESARRTIVMCYAVIMLFALMKDPDGQTEIDPGPWAYVHRWTLSRSLWEAGSSFEFDRMWKERPQFVVANFALESFLGQGRAEDVDEFAEIMLSVYIGVDETKEFVSGRLGVQSIQSPVAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZL4</accession>
    <name>A0AAE0NZL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_466074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZL4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="36604" checksum="E6DA0D5BA7CFC90B" modified="2024-05-29" version="1">MASQPTPAEQVPKQEGEKQAEGEKIENVDQVEQPQLAESSHVDDSNVVDNEHDDAGDVEEGEEYDEEDPEAEIQEVLADDFQNGEGEEQEEEQEALPEPTPEAAKPKKGKKSKAAPVPEPEEEEASEPEAPPPRRKSKKPKAKPIPEPEPEYSDESESEEEAPPPPPRRRSKKPKAKPVPEPEYSDSEEEEEEAPRRRSRRGARTSSTPGSSQPATPGDDEKPQPKWMTRGKKSTNQNQDMERPASRRRRSKREEEEMSYRQQQQMLYQQQQQQMMMQQQQQQGGGDSGGKNPLRLRLDLNLEIEIELKAHIHGDLTLALLDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZU8</accession>
    <name>A0AAE0NZU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_466244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="56010" checksum="8160D89C79DA11F5" modified="2024-05-29" version="1">MVSCRPSPSSYALAANSPTPELVFLSFSRDPTAHLPRSPPAFGLGMTQPETQNMSTINPNIANGTCYYAENTVTKGNFIPCGNELIQTWPCCKAGSYCLALGDANACWDAKSGNTYVAGCTDPSFVSPNCLHKPPPFHDQEWVAINQACTNLNANSKVDNITNWTGCVVDNNSTDLVKLPLAACTPYCDATNVLYAGVSSLPAYASLPTLSGSSIFWQNDFVPPTTAAPGYAPGVTTGIVGTGVSSKPRPSSSGPSMGADSSDLSPGAKAGIGVGAAIGGIILIAMLTTLILWCRRHGKRKQQLGLPPPGRPYNQPYSPDDMSNYPPSGGYPSPLAHPYSNTHQYQSIPGQPPIAEIATPSTPAVAYTGYKTELPADERKMRPSQGQEYVEMDNGDINPVPAQYLQPQPSPRGHQEQDQLSPHQHHGIAPPGSPPLSESSTMLHSGHHSYTSPSLQASPASAYGQPAGGRPSMGPGPGVYHSRSTSSQSQSFSSRVAAGGGLSPGVYHGGSVSSIGASPGTGYSETEGGWEAGRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZW0</accession>
    <name>A0AAE0NZW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZW0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="603" mass="67518" checksum="367BFA226A42B8BD" modified="2024-05-29" version="1">MYNFCLFHWTGSPDCLLESRPVSGTDKSTLTKPPSPSESKSQVIGAGVVKETTNHLLYPSPAACAGLRVRRRTPNMQVDDDDYFHLAGKPISTRRGSSNGWIQFTIYLLYGFVGRIDWEVSIGLIEFYVLHYALLGHISQGLPPRAARPSRESLVKAALFLLLDRWLNHVEELQTTGHVLVSIGLDASRHPVRYLCLEPFGLIKQTDLIGFGQCHNPFFGRRDHDESQIASYDGRVVGNGKKRPGFISHAFLGIDISGKVMGETQNLKVVDVTCSPEEGRKLSQAYKEEAGSIEQLKTGYGVKIVSPVNIKCSHDQPIELFAQRVHDAGHFAVPKGGRLIGPIYETDGLALNLVWALQLPNGKEFASVSICAHGYGTLNGAEMAEHEFRSQFNLRAMSGATWFDMDKYREEGSVSDAMNTDAEHGTVTTDTEPVTEQITEQVAEQRERRRLEKIPQAKSEKRELETPPDYTTAMSIQDTERTTNAYKVLCRPSKRLMGTTKDRTQIAIGFHGGPKMLPATRPHGPHQDRNYIVAVQVSGFEPVPFLTFIFQRVVFLNIDDVFHLDRMTFNLHARSSGLELITFALYDTDFQKDEVTHYMTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P066</accession>
    <name>A0AAE0P066_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_493066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P066"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="468"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3390897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="646" mass="70080" checksum="4456745A5D66C7A9" modified="2024-05-29" version="1">MSSAAENEAQTGRGQPGGAPATTTSVSPARSPYPSSAEAKHKREFLISVLESSATKRDAKAYLQTFGGSVAAGAAGPKKPPTSPVLHDGIRAVADMPLFVQGLAKENLKEADETPHVAIVKMRDPQAWGDDHLDGVAKTLTQLRDLGMLSVIVLECGAEESRAPWQGSVAAEQSNRIIQAIGRYGSPSAEIVDSSIWKMLDPPSQGAVPISSSTVFVGFDRALTTPLKHGHILVVPPRAYSDRDLGFTTANSSEVVFALTAFFSGLPIGGRPSQSGDQVNEEGRPVCRASVDRIIVIDPLGGIPGRHGHGAQVFINLEQEFDDVRNALASRTSAGIPDEKSGGEKHLENLELVKATLAILRPNASAVITSPAEAANLKEPQPGAHGADVEQFAGEVKTRRWQNPLIHNLLTNRPIYSSSLPIGRIKPNATDTEVRMPRMPTTTLATKGMPVTIFPDPRTTRWQPPQPGGPRLRLTDTCIDLPRLIHLINDSFSRKLDVEHYLCRVENSLAGIIIAGEYEGGAILTWERPVGMDEETAYRSGRLVPYLDKFAVLKKSQGAGGVADTVFNAMVRDCFPDGVCWRSRKDNPVNKWYFERSCGDQKLPDSNWTMFWTSPDASLHERLIQDYEDVCRNVVPSWADTKQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P491</accession>
    <name>A0AAE0P491_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P491"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042034811" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15109" checksum="A12BE8F3282D0635" modified="2024-05-29" version="1">MASPRSGLRAVSLFCIFASACLPTAVKDESVHPAWVLCFGLFCSKYEHFGVEYARECFFGNAFTARTADAADCNFPCTGIADEKYGAGNRLNIFTNDAFVPIGTAALDVLYLSCFVDNGNPRILPDNALGANDMTAAKCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4H1</accession>
    <name>A0AAE0P4H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cortical protein marker for cell polarity-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_12486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4H1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041970032" evidence="3">
        <location>
            <begin position="36"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="5">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="6">
        <location>
            <begin position="394"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="4">
        <location>
            <begin position="914"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1241" mass="129984" checksum="E8458D1EADDF065E" modified="2024-05-29" version="1">MRLPFRRRHAARSQPLSTFISLLTLSSVALSPASAITFTPAPAANLDLSQLGRIALAGDFSGISLYQFEEQNERPFSTNGSESLLARMPNGAFANIVETDASIQAMCTFTMSNGTVLGVVIGGNFTSLDNMASTAVALFNPNADKDKQVIPLTGISGQVNALLCDQDTNSVYVGGNFIGANSTNAIAWVGTQGWTNLPFAGFNGPVTSITKASNGHIIFGGSFTGLGNATAPSTPDGQVINLSTAKITSGFSTTAQGFSNASDIVCKAGLGGSGNTWLLQDNTPGFWQASFRFGFQPTKLRLYNTHENGRGTKTWRFTALPLNGIMNFTYIDPATGRNASCTSECPLSNDPLVKFQDFHFVNVIGMNAFRVDISAFYGSGGGLSGIELFEDDIFAFAINDFNEPTCAGLRFPSSATPTGPWAVAPSRSSSSEYLTAQLSGSITPSSASIVFIPDIREAGNYSVNLYTPGCLQDDTCSSRGQIHISGNMTQESSKSTPIDRNIFQTNNYDKYDQIYFGLIDASSDSFRPRITMTPSPGQSLTNMTFVAQRIGFTLINSTGGLNGLYEYIPGTVVNASDFQSSAFNRLGGGFAPGSAVNALATAGDITYVAGNFTSSEARNIVAMNGRDAKDKDLDGGLNGEVESMFSNGTKLFVGGKFTSTLKNPAQVQGLSNVAVYDTEKNVWSPLGAGVNARVMRVVGLTMNITGPTPEVVISINGEFSQLEAFGNNPAVAVSGFGIWVPSQSNWLQNLNLPVEWIEGILSTSILNVPGGNSLYAGSIASSTLEARGVATLGDGLARLPVNFKGSSPSAGSGSLAKRDNTTNSTVSEGVSTGVFDTNSGRNLTILGGHFTATATNGSVIHNLLFFDGSKEEVSGIGSQITPESVFVALAVQNDVLYAGGNVTGTVNGASVSGLVSYNLGSKSFGTQPPSLNGGNGTVSSIAVRASTGDVYVGGSFKSAGSLGCPGVCFFSTSSSQWNQAGQNFDGSVNTMMWTTNTILLAGGNITINSTASTFLAKYDTDKQAWDTYPGSSQLPGPVKALTAGTKDGSQIWASGTALNGSTYLMKYDGSNWQAVGQPLQPGTDIRGLQVFSLTSSHDSTATIASNEALVITGSVVLSEFGTASAVIFNGTAFRPYALTSNSGNTAGTIARIFTERNNFFTSPGGSQLSLVFIVLIGLAISLALMLLIVLAGLFLDRLRKKREGYVPAPTHMFDRGSGIQRIPPHELLESLSKGRPGAPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4L2</accession>
    <name>A0AAE0P4L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_530921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="228" mass="26026" checksum="7AADBEE10C74B53A" modified="2024-05-29" version="1">MRPADLAKLSLARLPPELQLMIAEAMVKQTQLVYVDIYGPEVLGGAQGPVDQFKRRVLSEARFVVQLPGLDKALRATCRLMRHMYHKHRPVWRDQFNNLQKYRIGPAADILLLRIHREAIWQEFFPENCPITAPMRGIFHECGNLALSGPQGLVVPSRYNPGKAAYLDFLNPNRNPLIVFYEASRKEAETLVIYPQDSFTKSLTFGEIADRFLKSQLRSPWIPEADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5W6</accession>
    <name>A0AAE0P5W6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_459431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5W6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="250" mass="26645" checksum="C6D066E7553F165A" modified="2024-05-29" version="1">MVTTYAITVSNQCNEPRAFLLSFSPFNNSTPLSNATNPIYQQSPILESGPHSQTTFSLTNEYFAVYGTMSTTQVGNVHVTSSNSMGPVTLGPNGTYAKLATINGDGVDPAWDTTPSAGVEPKTTAAPGAFTIETDQYLKPGNPNNIYIGLGARDPTNPNRVVPVTTFAAEPQTKNIITPVPKYYVCAYYHGESATMVETSMSDGLAVDFSGAKGSNPQASFVYNKDGKFVPADDSMTANGVKWTFGQDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P666</accession>
    <name>A0AAE0P666_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_34141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P666"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="173" mass="19015" checksum="E0E3B8C570C090B4" modified="2024-05-29" version="1">MQVDKLVPHIGQSHPTPLLPCHGSLASAFPPIQLGPPTCLLTVVHLLSFLYAVLDPGANEARLVDAPLFLPQRLAHSGNPHLTYCFSCIVRRRGNPAGQNVHPDKCLARRLGVHTIPNRDSKRKVSFVASQLYTFSLWSALWGFANAITAPKRYGIKKATSFGSLSFARVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6H2</accession>
    <name>A0AAE0P6H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_38841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136921" checksum="0C610EE2AA14ABA4" modified="2024-05-29" version="1">MAGVLKMENGTQNGARSNHDRDTWTNEVNGSDVKREISPDKGKGLATMSDINTAARINDGSAMDVDGQTPHAGSTMNDLPDEIQDITANLLPLSHILMRIAQFTHSSLQDEILTLASKALPQGIVNGNANYSYSSAEDTSPESLEKKKSLVDWSMDMHTRWTKLLVIAEWSKRSEQVSRLISIRGHLVETMALYPRVFWDMVGKVKHELRFAKVPSPDLKTALEILSNADASWWPDFGYIPLPPVSLEERESWIENANTLLSVRMSFHEHETLPLPFRGYTIKSGRVTFKVKGEFEVDLTISEEDFEKQFWFIDFRLDYSPAPAELSETARLVLQDRVNRILATDGLAGCYKYLHEFVLTQKIGEFCRQAVELSRARWVDTLKVERLHRAMSIQYWLNRPHSSGSKSWAIIGVHSGRNADGSQDPKATSYIKLRWFRDNVEVRDLEIPFDVDDISIEALLTTVISRHVEYLLSTIYNKLVIKPRFAQRQARLALEVSKDDPLDSSLTLQLFDDENATLRVDPLTGSFTLFPQHRVIVECQRRFNASTNPAEEGAGFLERLRCEYTLKDLESRARCIGWTVLKPFIPSDELKSIVYSNNLPATARESYTARWLRKQGWSPQWFVMMSLSLGGDQWWLIELSAPRPNTIAGSGRLKTFIKMPMASGQLSLSDTFFQNLTVYATGMIAQLTDLRELHTKGMAHTARVSSNYNLFQQIKIPTLYVRLSDMLRSRAGSTRETPEPWAKDFIPIIFKGIQNDLGDQEAAADAAPSSPRRVKIIAEARLAVTDKSKFTFLKGNVDHDVAYNSRIGQFSLRLRADMGTPVVSLLSTRIQALERLVDFVEAIRKAGKNAVPESVTLREVVFTYCSNPPASSPPDGSSEGQQPPSQAWKVRLDLAKDRGDDVRVVLEKGNPHLRVLDFLTAMANSAKFETLPFCLLFTLPLYRGLEKVENTWEAIAANNEGSFQVFHKSLTWVTVRFSLPCPPGSRRQLNLDLQPRVRNSKLMWHVYRPNGDPADKGRNDEFDKVLQEHVWNARGNGVKGLVTGAAADPERGVGNLLDLIDESVRSLVGTPPPPPPTPQQQQAQAPGQHEPMPALPAAPAAGPPQQLPPPGGGAGRFPQQQQQSMHQMQQLQQTMHHQQQQQQHQSMHQQQQQQQQQQQQQQQQQQQQQSLHQQQQQSLHQQRQSMAHLGVQANMGHPQQQPRPGANSNAPLVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P700</accession>
    <name>A0AAE0P700_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_532671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P700"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="201" mass="22503" checksum="625239B21206E238" modified="2024-05-29" version="1">MLNARPSSSTSSSSNPIYFWRDIEDQTGWLSQWYPCAFTDDAGRLYKTAEYYMMYHKARLFSDIGTGNSILSAGNPRKAKSLGRQVANFDESVLAAECQAIVRQGNHLKFMPPVIDESELRRGASDAAPLVGMTLRELLLSTGDRELVEAIPFDNIWGVGFTALDAEMNREHCGKNLPGKALMEVREIFKEDENKKTGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P733</accession>
    <name>A0AAE0P733_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_461363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P733"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="92" mass="10577" checksum="2CFBDBB539CB3E40" modified="2024-05-29" version="1">MVKRVYFLAHGGMVQGVGFRYFTQKRAVEYNLTGWVRNTDMNQVEGEAQGEDDAVQSFLKDVDKGPKHSHVVRLDKEDRDVVEGETDFSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Y7</accession>
    <name>A0AAE0P7Y7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_444978</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7Y7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3394892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="205" mass="23481" checksum="257F39C7FB6CA958" modified="2024-05-29" version="1">MADVDDNQPLLGVNRPNQSDNTFQSKYDRRKSQTRDLLSSKVKHYIILGLVALDVTAILADIFIALLSCDLDLEQESWVWKAREALHVVGLVFSSLFVLELLVTFWAFGIQFFHDWFHCFDAFVIVTSFVVDTVTRGDVELIASLVIMLRLWRLVKIIEELSVAASERMEDIEGKVVELERENSDLKLQIEALRNEHWDQSPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW76</accession>
    <name>A0AAE0TW76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_524353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW76"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="133"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="333"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="51038" checksum="F85295366EDEF8BC" modified="2024-05-29" version="1">MATHSSSDTGLPGDSVIRNTPVAPAATGTPQINNNAEPTEEIVPSSMPARQATTTSALEGDDPLNIGRHRRENVSKKQLKLEHPEGNKRKLKKYYTRQNELIDKFLGAGDEEHNAIAEDAKYQPKIKFAVNMSFCVNFFLFIIQMYAAISTGSLSLFATAADAFMDLVSSFVMLVTSRLAARPSVYKYPVGRTRIETLGIILFCALMTTVAIQLLIESARSIGNGENHDAKELHIIPLVFVGVAIFAKSSMMIYCLFYRRFPAVQIFYIDHRNDIVVNIFGLIMSIVGDRFVWYLDPIGAILIALLILFSWVTNAFEHVWLLVGKAAPREFVSKLIYMAMTHDDRIEKVDTCRAYHAGQNFYVEIDVVMNEELPLRITHDIGQELQRKLEGLPEVERAFVHIDYEHAHDPHEEHKPLYERKQAKPGRSIKDILLFRKPAMAAQAMANAEESPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWB6</accession>
    <name>A0AAE0TWB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_495312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32125" checksum="15F94E91C7946DD1" modified="2024-05-29" version="1">MTATTTIEVPHLGGIKAGYSLSGEYDPKKPTCVLINSMCTTVSLYKNQFASKPLTDALNLLAIEPLGHGATSSPVEHFTYWDTATMALQVMDKLGIEKAFALGTSQGGWMVARMALLAPERILGLILLGTSMDYESSDSRSKGAWDPKALLAPFYESWCSTTPTPDFLIDDVWCSMVGSLGFGAGATAEVIGFWTQTLKAVYKGDEGRKKVKVALACLLERDGLLLRIRDITCPVYWLQGTEDAPFGTKIPAEQIKLFTSSKEATLSFVEGGGHYLNATNPKEVEDALLSMVNKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWC2</accession>
    <name>A0AAE0TWC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_476801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWC2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="24546" checksum="51479F25BD8DFF0B" modified="2024-05-29" version="1">MPGTSLWLLPPPTHPLYPALQTLISRTLPAAFPTETAALSPHFFAPHITLTSGIAPEVYGADPQAWLDSLPLESCVGKVRVRFTGVASQDVFVRRCFIRVAASDEGVRQLAVLARAHGVYAGDEKKAREWLGEWERRCGPHVSLVYGSMPMDEDKQQEVVRIVTEAGITLSEEKRDRVQKEEEDEEANDESWNGWDGGVLWLVQTDEPTAEWTPIVTRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ27</accession>
    <name>A0AAE0TZ27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_169230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ27"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041945170" description="Ribosomal protein s17" evidence="2">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="53672" checksum="D91BFAE139967B46" modified="2024-05-29" version="1">MMTIKQVICISSFFGLILAQAQNGNNNNAGGNTLDPAVIQQGSTVDGTNSLGAEAGQARSQTSTNNFINFCKGQTLTNGFQVTAGSCNGIVMGQIPAKSNMISSVITNPTNGQQIQSGENFNITVQVLNLNAGSFTNAAATYYAAPQTLQNGNVVGHTHVTVQDTGNNLNPTQPLDPTVFAFFKGINDVGNGAGTLSAVVTGGLPAGNYRVCTLTSASNHQPVIMPVAQRGAQDDCIRFTVTGNGNTPNDAANNGAKGLAAAALIEEARTLGPGAPNPNAGAVNAGANAAGQQPGQNGQGGNGKGKGGQQGQENGQNGQNGQNGQGGNGKGKGGQQGQENGQNSQNGQNGQNVQNGQNGQGGNGKGKGGQQGQENGQNGQNGQNGQNGQNGQNGQNGQNGQNGQNGQSGQNGDGSGKGKGGQQEQQNGQNGQNGQAGQNGQDGQNGQADQNGQNGDGNGKGKAGQQGQQIGQTGQAGQNGQGGQNGQNGQAGQGGQNGQAGQDGQNGEAGQGAGQGKGKVDAGKTARLARLARRRTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZG8</accession>
    <name>A0AAE0TZG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_472224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZG8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="23116" checksum="DB16164782A5E58D" modified="2024-05-29" version="1">MARRRRPPRPGALTELPPLKILAQIAALQGLYYTSALVLMLFSTLVAGTSFSADLIFGWAAVRGDTTQGWLMGFIWMLDGGLLMAIAIVSLVGRSKLVLDFSLSLHGLHLAVVTLHTGQLPSNSAWWLAMAASSVVSVALATWGCRYRELKPISFGGNGPSAAAGGSGEDNGTRAGDMSGGDGDEEQGFSRGRGRDRGRDGAGEYEMVTINNSNNNTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZR1</accession>
    <name>A0AAE0TZR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_183276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZR1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="129" mass="14804" checksum="FE8BCD3DFEE63F8C" modified="2024-05-29" version="1">MQLAEYSTPPATLPPEALTCREGFCAKNPQTFEHTWQLNKHKKKHTLPYKCLAEGCAFSEHGHPGGFTQRRDLEKHTATHRPRPSFRCHVPGCESRATRDYNMVRHLKAQHGIRIQQRKVSELCSRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZX1</accession>
    <name>A0AAE0TZX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_494579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZX1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="449" mass="49034" checksum="C069AC79603AD9C9" modified="2024-05-29" version="1">MTAAGPPPDPAAVAAAQAAALAAMHQFAIEAWTLLSIGLAMTILRTYARIRAVGAKGLQADDYLVWVGATFYAIETCLAYSVGQVAHGFANNGMTDEQRAALSPDDPEYSFRVTGSKIQLAGWSSYSVLLWSLKASLLVFYLRLTAGLVRGYRIRIYIGFGFVVASFLIVVMNLFLACRPFHKNWQINPDPGNVCQPAISNQIIWVYLTFNVATDLYLISIPVPMLWNTTLKPLKKMGLILLFSGGLFVVICATLRVVLIVTDPENGAQLAGSWAVRETFVAVITTNLPMVFPLLRIWLGPLLGSLLSFTTRASRSTQKLDDKKGSSDAFGEASSQTWRRRPPATANPITNITFSESEERMVDGGVKLQDLKAWSDASHSELSGNNVADSNAGNIRKHVRVSIVSEDIMSVRDRHKAVSADEEQHLPPREIGAFATARGPKRSSFHFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U082</accession>
    <name>A0AAE0U082_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_544269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U082"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000036">
        <property type="entry name" value="Putative glycosyltransferase family 31 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="573" mass="64968" checksum="A429508BA75F54DC" modified="2024-05-29" version="1">MKMALAMAPAMAGSHRCFSARNPLAKALALTLSILIIGSFLLRSDTMDVRTKIIKSATSAKEAISQQKALVNYYHNGWGSGWHTPIEKVGSHPTAVVTSSHPNSSHTITCDYDMAKIREWQKKYKLQERIEYTKRYVQISRQDISRRPLTKLQQKFLPEQARAIDVNKQYEPETCPEPLLAPVTRSPFPATANASDFMFGVSTTYKRFTDPKTSPINEWSYWLTDSEGRSNGGKLILMLLDASDDDLADADRRLRQVGIDVDVYRSDSSLEMAVRYLALVPTLYNHRELKNKKWLVTCDDDTFFPAFHALAEKFEGYDDSRPMYIGTFSEDVNNIARHGSQAFGGAGVFLSVPMAKVVAESYDSCRTPEKVKESNSGWGPQGDILLRKCIYENSETKLTLLQELWQLDLYGDPSGFYESGIKPLSLHHYRGGGWHLAHPWHYTKVAHLCGEDCTLQRFITEDNFIISNAFSVAYYPSGVDFDVNQFERTFGAAPDDKGWNLDFKLGPQRPTLHKTGRKISWDLQESSINKDGSVSQVYVRKHDDWRWKMPDDTPMSDLDGIVELVWLPDQNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0V5</accession>
    <name>A0AAE0U0V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_540852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0V5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="343" mass="38174" checksum="6BED18A253FB8536" modified="2024-05-29" version="1">MLRNHILRQPQGGQDLVLKIPLANVANMLEPAERKKVMGRNRPGTERRLLMASGSEIHAFEDRSATPGLQPDNHVAISYAWGPPEPTVEIIINKEPVKVGANLESALRRLRTMSYFSSGGKLWFDSLCINQDNDAEKSVQVQMMASFMATTETNQAISYLEHHGRNYRAEFAEALDRSDALMAHTWRHIRDGVLRYTILDIPEEVTREKLGHQDQPREHSLRHVAQIAQLEIMGHKRALPNVPSGLLPIVAPTYFQHGPSLGNAIRRAIALASQSACTKPHDRIYGMLSIPGLPDLGVKVDYSKKLANVFTEFSAACVKHKNLDFISLLDQGGMSATDEHGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1P4</accession>
    <name>A0AAE0U1P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_164815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1P4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="147" mass="16309" checksum="99EB1092F56E35EB" modified="2024-05-29" version="1">MVGPKHDYVKEQIVVHIRADWRSLRGQREPSTTGQSTGLASPVQTGPRQISALEFAALIKSRGSPRLQFRIDPKGPISEHEPDASFGLVSADYPGVVLEVSYSQNAKELVKLANKYLLDTPGPRIQVVITLAIVWNFLIFHLRPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1R4</accession>
    <name>A0AAE0U1R4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_156647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1R4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3387384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="30653" checksum="C402BEF3FFACBA87" modified="2024-05-29" version="1">MFPYVDSAILEALGLEATSSKLVSHGGSGFSSTYKLVASKDGAELIYFVKTGTGAEADVMFRGEHASLNAIHDAVPNFCPRSHAHGALQSSAGKFFLVTDFLDLGSSAPGGSGLSLAAKLAKLHTTPAPTSKFGFPVPTCCGATEQNNSWKDSWAEFYANNRLRTILREGVKQHGADKELADAVEKVAGSVVPRLLGDGHLKDVVPVVVHGDLWSGNHGRGKIAGQGGAEEVVFDPSCVYGHSEYELGIMRMFGGFGSAFWREYEELVPKAEPKEEWGDRVMLYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1W0</accession>
    <name>A0AAE0U1W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_165272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1W0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="214" mass="23619" checksum="BB59CD6A47E85C23" modified="2024-05-29" version="1">MYGGSAHRSTSYRGRHGCLHPPKLRPSSIPWNMCASFLDSGLYASMTFEATRLIGVMPLLGILLASPDLTKLGLSMHKDTIKEACKIDGCSAAETICCKNREVSFFLALCRSYNMMGRQPLRLKSLELGLGMLLDDTIEPPNVNLQNLTPGEFDMTHEQVKRRAHELIQFADPSALEVLCIFGSPLTVTITSSRLGIKQSHAIFFVADIRSCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U217</accession>
    <name>A0AAE0U217_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_167365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U217"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042247162" evidence="8">
        <location>
            <begin position="26"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3387966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="557" mass="62149" checksum="1E571E5EFBB5B060" modified="2024-05-29" version="1">MFLLLAGLLFLAPVWWLASSAWCLARNIQAARASGLPYLVLPLNPDNPLYMIFSVPLWPFVERFLPGSLHDAVLATIYGWEFLEKSSLFHRIGPVFILVTTGLNRVMCGDAAMTSQVMARRNVFTQHSISKTMMGVFGGNVLVADGDDWSRQRRIVAPSLNERISPTVWRESIDQATQMVRSMLALPGGETRGSVHGIRAIAINVIGRVAYGDPKPWLKPIEFPTDPDADMSYTDVVGLMTELIIVAALVPIRILRLSVMPRLLQTLGAAMEKMPRQTKDMLDYERHRAGDGHPDTITSRLVRLSDQAKLVDHDKTASKQYLTEEEISGNLFLFTTAGFDTTAFTMGYALGLLAAYPEWQRWIQAELDQVLGDDAQPEYTDVFPKLTRCLAFMLETLRLFTPILHLPRDVLSSGTTLTTTSGTAHEIVGPCIVYLVSTYLHTNPADWGDDGDAFRPTRWLNPSPKEGEPPIITPAPGTFIAWSGGPRQCPGLKMSQVEFVAVISTILRTCSIEPVTKDGETMDQARQRLLDVMQDSQPTTTLRMKRPEDIHLRWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3L6</accession>
    <name>A0AAE0U3L6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_98380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3L6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041929553" evidence="2">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="42057" checksum="89B8C9380F248F5C" modified="2024-05-29" version="1">MILRNWNFFALLAALQLPALGLAQHREFYKWNSPRAVANAGRHDDGIFGRQTPPGYHPEFGTCGSGTTCENACGSNWQSCNASTNLSLFCYNQKELGQTCCENGSGRACDPGYYCAWNEIGGKVWCCENGQSLEECGVITSSSSASGSSTRSSMISSTKISTTSSPTGPSGSSSTPTGPSSSGPSSSEPPSTASSTPSGTDSTTSSSTGPACSATASYCSSVSLVTVTTTTTTTTSIFEATSTLTVYVDSPPRTVTAFSTISIFITVPIPEGGCSSTTSPSSPSPPPPVSSSTPSPPSPPPSSTAPTLPPTPEPPCPDSTTFLVPPPSPPPPTHTPDHTVGPPGVVYTTKIRTITTTTTCPPDVPNLKLVANPTAPADLLPGPVLPEMTSGAQVVEAGGVGLALVAFVMLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3R8</accession>
    <name>A0AAE0U3R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_409597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3R8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="268" mass="29004" checksum="C7D884B0B82D1D5C" modified="2024-05-29" version="1">MAETTTTTKGKFPEVQGGGSLILAWQVKGKKILVVGGGEVAAGRILNCLNADAVVTVICPSSGLNPDVAYRVSQNQITHIDRNFLPSDLEDSPQSIAMVLVAVDDPEASTQIWQLCKSLRIPANIADVPPECDFYFGSVHRDGPLQIMVSTNGKGPRMASTIRKLVAKQLPVNAGNAVESVGQLRAKLRQLAPDIKDGPKRMGWMIKVSDAYSFEDMCGMTEEDMDNLLRFYFSDRVPSLDVLKALRGNTDLARLDVFDGSFGFSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3U0</accession>
    <name>A0AAE0U3U0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_507122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3U0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="558" mass="63108" checksum="3E0F8B2F05E7BB3E" modified="2024-05-29" version="1">MVRLSPRLGGQDGPEDRLQDQMDHLGTKLEPSSENRLKRLTKAITWALEKKDVHQALDQIERAKTLVVLAIQNDHFKLALSMKEDIDHTKDELRDAIGDAASKHKDEELQKITNWISSLDFANKQLDFLGRREVGTGEWLISDPRFQTWIEGKERKLWCPGLPGAGKTTLAAMVINWLENEYRDDNTPVIYRYCNYKEANIRTPENMMRSLLKQLIKRKDALRGDVRNLYHDHLGKGPWMGLHDHMPPLWHAVFNCRKALAQLLPDSGADINDTTEETFLQRSRLLTLASLRGVLRVDTEMAEFLLVRGIDVSSTNSLGDTALHYAVGAGPLSEIPEEKLVPIVQMLLQYKANPLEKGAYGRNAVHEAARRDSEPVLEVLVEHLATERCSEDDNDAKRWAAAISLYFATLKGNEVQVKALLQDEADPNLLTWGHLDPHLEHVAILRQNATVLHLLLQGGALGNVADNHGRTPLLSETYMGFDAGVRLLLDFGDADHFGLTPPEIPDHWHKETPLPLAAERHNVSVVKVLLESPPRAVKPRDRNGRRMRFGNAWQFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4K6</accession>
    <name>A0AAE0U4K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec63 Brl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_114204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="293"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="517"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1960"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1979"/>
            <end position="1988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1994" mass="223129" checksum="7EE3175BBD3AB6E5" modified="2024-05-29" version="1">MAPSAPDGLSIAQWRAQVESMKAAVARLQPSQTTREPDDSDWDDDDIDSAYEPRSSPRDVWDFISDDELADIPFDSEDAPDGVDGGPAEMAHGLRWLAARCVEVSSRRSGLDPDALQSQVLDILNASRPEDEIQSSLTDLVGFDDLDFVIDLLSHRPEIVAAVAAERVRNEATGSELRLLTKAQREEALRRRDLEHKSTPLAAARAKEEEYPHVYKTFSAGNTLNFAGKRYALPVGSVRKEFEKYEEYSVPAGKVGTLGVGRKLAQIADLDGLCRNTFRGYTALNRMQSLVYPIAYKTSENMLICAPTGAGKTDAAMLTILHTISQYLTPNPMEDHHATDFAVRADEFKIVYVAPMKALAAEITDKLGKRLAWLGIRCREFTGDMHLTKSEIVQTQIIVTTPEKWDVVTRKGTGDTELVQKVRLLIIDEVHMLHDERGAVLESLVARTQRQVESTQSLIRIVGLSATLPNYIDVADFLGVNRRAGLFYFDASFRPVPLEQHFIGVKGKPGSKQSRENIDEVAFEKVREMLELDHQVMVFVHSRRDTQATAKMLYEKAIDQACVGLFDPSGHPRFESAMRDIKSTKAREIRDLVPKGIGIHHAGMARSDRNLMERLFAEGVLKVLCCTATLAWGVNLPAAAVVIKGTQVYSAADGKFVDLGILDVLQIFGRAGRPQFEDVGIGMICTTQDKLSHYLTAVTDQLPIESRFSAKLVDNLNAEIALGTVTSIAEAVKWIGYSYLFVRMKRNPMAYGIDWKEYDDDRALILRRRRLAIDAAKQLVQSQMIIFNENTEELRSKDIGRIASQFYIQQTSIQIFNTMMSPQSTEEDILKMIAMSGEFDNIQSRNSETNELLAMKENRNFVPYNISGGIDLPQTKTNILLQAYISRGQPEDFALTNDLNYVAQQAGRICRALFMISLTRRWGYQCLVLLTMAKSIERRIWAFQHPFHQFDLPKPVLNNLDAKDALNIESMRDMESAEIGSLVNNHRMGGKIYKLLGNFPTLSVDAEIAPLNRDVLRIKLYITPDFRWNDQMHGISESYYIWVENSETSEIYHHEFFLLSRRKLHDDHELNFTIPLADPLPDQIYVRAVSDRWLGAETVTAVSFQHLIRPDTESVYTDLLDLQPLPISALKNSALEDIYAQRFQFFNPMQTQVFHTLYHTAANALLGSPTGSGKTVAAELAMWWAFRERPGSKVVYIAPMKALVRERVKDWGARLAKPLGLRLVELTGDNTPDTRTIQDADIIITTPEKWDGISRSWQTRSYVRKVSLVIIDEIHLLAGDRGPILEIIVSRMNYIASSTDNAVRLLGMSTACANASDLGNWLGVKEGLFNFRHSVRPVPLELYIDGFPEVRGFCPLMQSMNRPTFLAILNHSPEKPVIVFVPSRRQTRLTAKDLINLCGMEDHPRRFLSMDEGDLQLNLSRVKDEALKEAISFGIGLHHAGLVESDRQLAEELFLNNKIQILVATSTLAWGVNLPAHLVVVKGTQYYDAKIEGYKDMDLTDVLQMLGRAGRPQFDNTGVARILTQDSKKDFYKHFLHTGFPVESSLHTVLDNHLGAEICAETVLTKQDALDYLTWTFFFRRLHKNPSYYGLEISVEEHNSTAAQQIANDFMIEMVETSLAELAESKCVEVYPNGDVDPTPMGKIMSYYYLSHKTIRQLVGNAKPKASFVDVLSWMCRATEYDELPVRHNEDLINAELSRNLPFPGTIFELPMWDPHVKAFLLLQAHMSRIELPITDYVGDQTSVLDQAIRIIQAAIDVLTEMGHLSSTLEFIKLLQSIKSARWPTEPPLSILPGISEKTNNKLTLQEMSRSRGSLQALQKLARDLSLGPGAQTNRFLKAAAAIPNVHVSAVDLKTTSLTVNLKRLNPVTEREARIYAPLFPKPQTEGWFVVVADIARDEIAAIKRVGWSAHGGKAIQVGSRPTARAVIKLPEASGKRKLDVLVLSDGYIGLQYTLPGIEIPDAPQVDDGAKKGDPRSQGQGGEAGSGSSGVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7F1</accession>
    <name>A0AAE0U7F1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA synthetase family member 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_406912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7F1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="519"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68161" checksum="5C3B2355E968B0D3" modified="2024-05-29" version="1">MSLGFTIGRSFGSRFSSLSSSAAALISSRWLCRPASFRMASTLPKLPVFEAIARHDPDSTVVVHSGSGRRFRYGELLGDVCKTRNRLYETAGREDIDGERIAFLVENSYDYVVTLLAILAAKSIAVPLSPAFPAPELQYILNHSEALMLLSSAKFANKAQEVLRTELDEQPAYLQLAKFQGGSKHENVTLEKSGPGSAGMMLYTSGTTNRPKGVLLPQSVMTAQARSLLQAWEYIASDYLLHVLPLHHIHGTINALFTPLFSGSTIEFLFPFNADAVWKRFAAPFLTPDQTPDPDSVSPFTREKITFFTVVPTVYSRLLATHKLLDHDMQSATRKAISPANLRLAISGSAALPTPIKQAWSELSGGNVLLERFGMTEVGMALSCGLDVADRVDGSVGWPLPGVEARLVELDTHQIIEKGHERDADGRERVGEIQLRGPTIFAEYWRNPEATAKEFVDAKDGRGKWFKTGDVAVRRPVPNAGKSSTPSQKDWTRGDLYFILGRRSADIIKSGGEKVSALEVEREMLALPQVAEVAVLAVPSGKWGQKVGAVVILDREHLPEGGRWTPLDMRRALKGRLANYKIPQVLKLVDHIPRNAMGKINKKQLVKDIFQDEFSGDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7M3</accession>
    <name>A0AAE0U7M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_505434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7M3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="35468" checksum="04E82DB699D7D4B8" modified="2024-05-29" version="1">MPAQIPRRAICGIRSALRSSSSRLTTSTSIWRQSPALLSSFSTSTPAARVVIPPESPKYIMIPEPPQSSEVKLPPVRGHLPVPREIFRKREGNVKVKPEWVEKAAPFSAAEKAGLPPKTEHEARQRQMAASRRASLKSGLQGLWVRKRQSDQHLAARSAAKYQANVAAAMAPDASYDVLTRSSVRASTASTMAVERDPRRFQRAKSAAEKNRRISAWKSESRRDAIIKLYTAASNFIVDEKELEARIDKLFTKDAFSRTKTDGGVSIWDEFVPIKLSSMTTGKADDINLSLTLGSRHELSSMTTRRQSDVAEELTEGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Y2</accession>
    <name>A0AAE0U8Y2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_506554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Y2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042177592" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="121" mass="12893" checksum="D899ADDAEBAF4889" modified="2024-05-29" version="1">MPVMWLPALSSLALLGDVIWLLVGGESRCMSGQTPPLIFRALCHMFTSGLLNHTGTGVLLPALDAAAGFMRGTPSVPKKWAVVTCHDPDSPTLGEQFEMAGLLSASGIETRDHAFWRSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYC7</accession>
    <name>A0AAE0JYC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYC7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="268" mass="28969" checksum="6D42FFECC6F3BA94" modified="2024-05-29" version="1">MKFALRRRGLDRLGYWTCTHGKLDLYYTLGSPTQAHALEGRYSSQRLLRYGQPLFLLCTAYGLVAGFVWASGLNPAMASSSAGGGTARFLHSFLPSLLGMAVFLHFQSLDLKLRILHPLAAAPSQDGTTANRRLLFADYAACALMQSSIHEVRNCDWAVAASSLLSTLFVLIPILASRTFAAPALPDSAVRIFANLVASGVMLALPILPFLALLALLALLAWIPPPGRSFCALHLAMCLAGVLDCLASEEWGWNLQGPESREASRPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1R3</accession>
    <name>A0AAE0K1R3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_529704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3368002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36346" checksum="BFF326C3C3C9C9B0" modified="2024-05-29" version="1">MATFLDAFICQFRLSKITCDILSKLYGDNTGSHNDLKIFETLRLAFDVAWKLSAWRRSVPEDLRPRISLISTEPPLTKPTASLEAEHLQAVMALRFHGICALGQRPVLIKFLVFESDCVDADENFLCDSGVASLRACIRSCTECITPAKDIVDQWRDQRVLLSGAWWQTAYHAFGASLIIFGILLISTKLVFADLLSAEEIKAVHSSLRDASELLSPRLNDTLVILRCHGCLENFLQACDDLVDPSRPRHSVGDACDTEMPPPALTRALPSLPSANGSGLGVVDDALATAAHDAEYIEDGFTSFDIESFVSRPFSDDFTNFDWGDGSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1U8</accession>
    <name>A0AAE0K1U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_77896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="150" mass="17157" checksum="65B53398E699CB5C" modified="2024-05-29" version="1">MPLWLVYHPEGTFTTAESKQALVSNITPIYTDGGLPAFYVVVNFVQLPSSCMFVGGKPPVRPFIRITVDHLAVHFSDNVPRRERVLSRIDQALKPHIADNGYDWEYSIDETPRELWKINGVIPPPFQSGDEKNWATLNKPVEWHKTEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K226</accession>
    <name>A0AAE0K226_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GDP-mannose transporter</fullName>
            <shortName evidence="12">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_66899</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasmic vesicle membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K226"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3368045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="394" mass="42845" checksum="6EB576B9426357E0" modified="2024-05-29" version="1">MANMSNKRNEDIEMRPKDGQDFAEEKDSFLRRNSSQRPAPVPIAPIISKIDHSPGASILAYCLSSISMTVVNKYVVSGSSWNLNFFYLAVQSLVCTAAILLSRQTGLISNLAPFDPVKAKKWFPISLLLVGMIYTSTKALQFLSVPVYTIFKNLTIIVIAYGEVLWFGGSVTPVALLSFGLMVLSSVVAAWADIQAAINGIGHTQETSVALSTLNAGYAWMGMNVFCSAAYLLGMRKVIKKMNFKDYDTMFYNNLLTIPVLIVCSLIVEDWSSENLTRNFPPETRNALFAGMIYSGLAAIFISYCSAWCIRITSSTTYSMVGALNKLPIAVSGLIFFNAPVTFGSVSAIFIGFVSGIVFAWSKVRPSEKSASVLPTSKPMMSASSASNRDAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2T3</accession>
    <name>A0AAE0K2T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_404131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2T3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042027382" description="laccase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="85"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="193"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="420"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3368390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="593" mass="65010" checksum="86050C6AD8AD7C07" modified="2024-05-29" version="1">MRGCFNSPTAACCAVVLGFLVSFSLANPIVPHPVVDLLPRQTITPGGKPCGQNNATNRACWKNSWNISTDYEVTTPPAFNTRTVDQFPGPTISADWGDYIIVNVYNDMQDNGTSIHWHGIRQFGESNQDGANGVTECPIPPGHSKQYDFHVTQYGTSWYHSHYSNQYGNGVVGSLIVNGPSSANWDIDLGPYMMNDYYWETADRLTLRAELVANGGPPDSDNIMFRGKNVHPTGTGGSYDRITLTPGKKHLLRLINASVDNSLTVSLVGHNFTVIATDLVAVTPTVRNKLFLGVGQRYDVIIEANQAVGNYWFNATLETANNCGKTRNKFPAAIFSYTGASTTALPTNKGTPLVATCVGETGFSPIVSRTAPSTNFAPSALPISLNFPTGPRGQVFEWRVKNTPIVVEWDHPVLEYILEGNNSFPAMINLVQVPQADVWTYWVIQNDFVLPHPIHLHGHDFLVLGLGSGTFNAATMMNQLNFVNPVRRDVAQMAGSGWMVIAYKTDNPGVWLMHCHIGWHVAAGLGIQFLERKSEIPGLMHLDQMEPNCQAWRTYQATSPYLPKTDSGLKKRFAGEGGGLEGQVMEPAVRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2V8</accession>
    <name>A0AAE0K2V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_565260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2V8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="375" mass="39110" checksum="0236B6289B227178" modified="2024-05-29" version="1">MAPASSAPKKMKQYVAVKQGGPFQLAATADYPVPGPDEICIRNRAVALNPLDWKNLYYGQMVKAWPEVFGIDTSGVVEVVGENVTAFKPGDAVLSLAGHGGRAGAFQDVTVVPQHFASLKPACWTFEEASSVPICYLTAAAAVVKGLGVPLPHLKDTRKEKENGGEEPEPSQPPTPVKASENVAVQKVKAIKCVLVVGGSSGVGACAIQLLRMALPSAIILSTNSAMQNGRVAKLGATTSIDRNLEPPKLVEAIKAASPGGEGVDAILDAVGGAEKNSALFDVLTADGPKLYSQVFTGANIDVPTDVSTSRVYGRMVFETPGGMLSMRKIIELAEQGKFKLPLKVQVVGKGLDAIGAGLERLKEGVSGTKLVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2V9</accession>
    <name>A0AAE0K2V9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_497694</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2V9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3368371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="461" mass="51387" checksum="949A33E48FE326D0" modified="2024-05-29" version="1">MDYNTILQGKYPAKQHAKRVADFIRSKVPNASGVLYVESRATKLLEDNDEAEPFRQRRFFYYLTGCPLADCYLVYDIDTSHSTLFIPPIDPESVIWSGLPVSAEEALQKFDVDEVRYTNDINATLAHIGADKKQRSTAFAIPNQVSEHVTFLEFDDKNFSILKEAIEVSRVIKDDFELAMIAKANAISSEAHLAVMKKVKHVKNERELEAVFIGHCIAEGARNQAYHSIVASGRAAATLHYVANNAPMAGKLNLLLDAGGEWDCYASDITRVFPISGKFTKESRAIYDIVLKMQLDCIAVLKDGVLWDDVHLLAHKVAIGGLLELGILKGDKDEILANRTSVAFFPHGLGHYLGMDTHDTGGNPNYLDRDAMFRYLRVRGTLPAGSVITVEPGIYFCNFIIEPFLKDAKHSKFIDAEVLEKYWDVGGVRIEDNILITKTGSENLTLAIKDPAEIERIMASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4D7</accession>
    <name>A0AAE0K4D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_514157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3369918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="137" mass="15481" checksum="17DE322CAA3EB67B" modified="2024-05-29" version="1">MPAVNYPTNIRLIDEIVKWAGNNAPILAEIYSQKGGWEGWAQVELARAIPGWLGGSCSREYREVYTNHDRADIFHENPLTNRRNVIELKCQSAFQDDTNIAGFGTQYSIAAGRIQPANRQGFNQNTDTCPVVFWTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4R2</accession>
    <name>A0AAE0K4R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_305785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3370026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="388" mass="44449" checksum="80572CF7A46E8D12" modified="2024-05-29" version="1">MENETIRRSLASASKAKVPFLEYVSAHRGENRRRCLIYFIPGNPGLIAYYAPFLSTLRQLLDEEEARDGCHRSFHVYGQNLIGFDDADHEPPFSAAEAGTAPFVLEDQIFHSYDRLVEVGTNGTNVGSSEAAAQAQAFDEVIIMGHSVGAYISTEIYHRHHLQLKARQQQQVNGNDGTGVTEKQLVNLQAGILLFPTISDMAHSPNGQKLDFLRTTPFLDRYAHRVAKGFVDLWPGWLLEGFVRRVLGQPAHAASVTVRFLMSRDGIWQALHLGKDEMRVITEEKWSEDLWEMQDDDDTTSTTDAATERPNKFFFYFGVDDSWVSQEHRDRFIEQRRRHENGRTRIFIDQDKIPHAFCIRELPSFSSFFSLDILSSRCFIFVRRRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4X0</accession>
    <name>A0AAE0K4X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_527892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3370146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="334" mass="34544" checksum="1C823923EC939CF0" modified="2024-05-29" version="1">MAFERGGGRGGFGGRGGGDRGGGRGGGDRGGRGGFGGGRGGFGGGDRGGRGGFGGRGGGRGGPPGRGGPRGGGRGAPRGGAAGGARGGKKVIVEPHRHKGVFVARGGKEDLLATVNLVPGESVYGEKRISVENAPKGEDGAAATKTEYRIWNPFRSKLAAGILGGLETIYMKPGSKVLYLGAASGTSVSHVADIVGPTGAVFAVEFSHRSGRDLINMATRRTNVIPIVEDARKPMAYRMLLPMVDVIFADVAQPDQARIVGLNAKLFLKQGGGLLISVKASCIDSTAPPEQVFAAEVQKLREDKFFPKEQLTLEPYERDHAMVSCVYLQKEFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5B4</accession>
    <name>A0AAE0K5B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hyoscyamine 6-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_485731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3369902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="42135" checksum="8FBCD90134CDA417" modified="2024-05-29" version="1">MGAQHDFTSIPKLDLSLANDESTKPQLLEQLRYALVNVGFLYIVNHGIPEDVIAKVVLALPVLFALPTETKVEVAVDESPHFLGYSRNGTETTAGQIDRREQFEFATELDATWSGSGNIPLCERLRGPNQWPAAYPNLRPIVETYIAELTLLGERFLRLVAEALSLPSETLFSFLSDQHRLKLVRYPPATSKQEGDVQGVGPHKDSSGWWTFLLQASPPEVRGLQALNRAGAWIDVPVVPGSFVVNIGQAFEVVTNGVCRATTHRVVMTSSDNSDGSAQIPQERFSVPFFQGVRRDLTRDEAVGTLREHFARFRAMLSQDSGEVDDGGLEARKIDSPFLQGKYDTWGESQLRIKVRSHQAVGRRFYGEVFDKYMNDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5U1</accession>
    <name>A0AAE0K5U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_310587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5U1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="37698" checksum="30CF0E67CDC17238" modified="2024-05-29" version="1">MFGCYSFESIGTLAENAAPAAAAPEPVSAAPNHNDGDGHVAPEGGDMDTWPRPELIQPLQPNPPVISKTPTLVGLDMPSPPTVDNLVHKLSRQNLRFDSLGLPLPQSSPAISDKPDDPDILPTIQPWTGLEVDDELPVRPSTPTHRLSDTIPPLTLLDHGSPIEVDELAGPSPDIRPTNWQATKELYSNSVSARVNARLASMISTGTQCNVRSAPQPGPTLPTRLTTSSVVEERIPSWDLEVDEAYANGTADVDEEERVFTESIMSLRRAAGPGGIRKNMVAGIPLRYRLSTEAALRCPNVVRSRPRMRRRDKDSRSRRDSVASSGITSAMSSPIIPPSIPSPRFPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K640</accession>
    <name>A0AAE0K640_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_486813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K640"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="156" mass="16498" checksum="082C0FED3704E735" modified="2024-05-29" version="1">MFYEVQTRTLPRKSLTMANIVSPPILDPASASAVASQLPHHVVELPFPAYGYVLIIGLGLCIFGTMIVGLWTTGFNLFDEPTEPGPPPANITSSSSSEKKDPKDWVFARPTSGSGNNKKPEVSGSGSGTKPEGSSSRQLPQGQAGGRGGNQKRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8K6</accession>
    <name>A0AAE0K8K6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Complex I intermediate-associated protein 30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_282333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8K6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="44"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3371899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="269" mass="30477" checksum="7FDEEF6D3AE96C49" modified="2024-05-29" version="1">MHTTTRLLAKGFWGRSVDELKRLTNIAIKMEGIKGPAGPYELHNFRRPESLEDCKVFSDVEIGGASTASLTWVPAKTPSTIDPRTPEQDGAHGYVKFHGTISNQLPKDRPDIKRTGYAAWRTLDRRSTIFGKSLWDIDMYAFLALRIKSDGRSYFVNVQTESVEPTDLHQHRLFTKQPGEWETVLIKWNDFVRTNHGFVIEPQTEILRQKVKSIGIGLTDRIPGPFELCIERMWATNNAREADGVANAAAVKEGELKNKQGQNIAWRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K921</accession>
    <name>A0AAE0K921_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_282101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K921"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="210" mass="24433" checksum="07AEFE263E55CB53" modified="2024-05-29" version="1">MMFPVRWWIFLFLRDSGSIWLSMDSSFSPLSWAVFVIFVFFFYIGSYLFFGGASRLRSPLGRFIDGGYSDRTVDLAMRHCVLGCCLIVFRDCDCELDLKRDSRSSLSLLLRLLLSGYPMLHGRKKKLSDEDLDKIEKTLWEHGLEGRMLSYQASLRNWGLRLRSVTAIRRALHQQDWRRCIACQRSFASKELAERRVEEARKSLAAPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9R3</accession>
    <name>A0AAE0K9R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_496794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042149110" evidence="2">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="137"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="309" mass="32322" checksum="E99BEE22B1D9362E" modified="2024-05-29" version="1">MKLSIFLATSGAVLAAATPILRGRRLFVETKVVVDFVTVTVTEGVTPTMFGNRRPSPKPAVVSSSPVAPAAPTTPPVVVVPEPTPEPKVEPTPEPTTAAPVVVPSPVAKAPEAPAAAPVVEAPKIQEAAAQAPSGDDYQSTALYHHNVHRANHSVPAVTWSQTYADYAATVAKSCDFKHDLSPGGGGYGQNIAMYAGTNAADDNASHAASGGIGDGWYNGELHIFPSQDYGKPNPDMKDFEAWGHFSQMVWKGTQQIGCATQFCPKGTNLSKAMDGWYTVCNYFPAGNMGGGYGENVLPPLGQPTVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9V4</accession>
    <name>A0AAE0K9V4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_300784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9V4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="295" mass="33185" checksum="57BA0E7F5AA11654" modified="2024-05-29" version="1">MSKYGVMVMGPAGAGKSTFCASLITYLQLNRRSAFYVNLDPAAESFEHQPDLDIKDLISLEDVMEEMKLGPNGGLIYCFEFLMENLDWLTESLDSLTEEYLIIFDMPGQIELYTHIPILPTLVKFLTQPGNLDIRLCAAYLLEATFVVDRAKYFAGTLSAMSAMIMLEVPHINILSKMDLIKGQIRKKDMKRFTTPDTTLLDDDPADIGRKKPSSDLEEHSADPQDKDALMSGATFKRLNTAVAGLIESFSMVSYLKLDCTDEDSVQAILSYIDDCIQFHEAQEPRELAEEEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA07</accession>
    <name>A0AAE0KA07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_401409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA07"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF1">
        <property type="entry name" value="BNR_ASP-BOX REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041902580" evidence="1">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="385" mass="41967" checksum="EB41DED9DA2BDEF8" modified="2024-05-29" version="1">MFGASFVTLLLLRGTSAALQAVSHTRRSVEPFGFFNNNTIYQTSGNQSITYPRFAEAQDGTIFATASLSGPSPSYFPIFESKDGGASWKWISNITDTQNGWGLSAQPALAELTEPLGGFEAGTILASGNSWSKNGTRIDLYASTDQARSWKFVSHVAEGGPPNTTNGATPIWEPYLLTYNHSLVCYYSDQRDPKHGQKLAHQVSKDLINWDPPVDDVAYDEYIARPGMTVVAWIPPISKWILVHEFPRGNSSSYGVNYPVYYRLADSPLDFRLSEGLPIVINNNTAPNASPYVVWSPSGGTPNGTIVVSDADRGVVYTNRFGGATDAWEEHATPAGATYSRAIHILKDHPDHLMIFGGETFDDFGKGLLTPFTATVVNLTEILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDL1</accession>
    <name>A0AAE0KDL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_548844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDL1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="521" mass="57906" checksum="B439F8F4C52A2A00" modified="2024-05-29" version="1">MSILKTEAHMSEANMADNPDSEDETYDVAPWAVIPIRKRRRRSPADCWFDEFRETARDDYGLAHKHIFAINPTGTPLLVHMIDTRQRFVGPARHEILHSSIIEDLANNTNSTARLLNKLRPRGNHKEDTGYDPFVPSRIVDIRAPLGLPLDSETIRLVDGADIRGPWAALSYCWGMGARENLRTLTANLAQHRRAIPTTVLPAAVRNAIETAKALGFHYIWIDALCIVQGRRRRLGCRICLHGPHLQAWKGVGTAIAAWDRKQRVVIGLLELTGALYPVRARSMPATATGLGTVGSSLWLEGTALPHDFLVATTGAAAIHHIRFPSDQVIAFAPDLPCLYGDDVVDTYQAWSPALANSLRREEETVVAALREYRAAQTLANPIPGSSGQLPPPPADKRPTLDGLLSNRDSASTIPIDQAVKDTREDHSFPRSLCSSENCACRRGWTSPYTHPLWALKIGTYRMEPGSGRTFLKDYFLVLAKSPFIPNGYVWIGVATTHRWGDEAEYLRFYGQGEDTDIFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDM7</accession>
    <name>A0AAE0KDM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_255510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDM7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042066532" evidence="8">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="79"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3374694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="444" mass="49042" checksum="6C84F684E0F79725" modified="2024-05-29" version="1">MKTPLFLTFASHFLAASACLTELELKGGHIIDLTKSPLHRRQFNNFTRPSVPVTTGDRFNGGKFAPRGIGSQKNAVFDSILNVHEIQSAIKGLVKEFGVEYFETPYKTYENTTMFGAKIGGGKSNRDYHVLLQSGIHARERGGPDALIYLISDLLWAKREKKGLVYGGMSYTYDDVKSALDQGIVILPLVNPDGVAFDHATDLCWRKNRNASSATPGIPSSVGVDLNRNFGAAWDFRTKLAPTADLFGVSDDPESEVFHGTGPLSEAETRNVDWTMGQFPNLGWFVDLHSFAGVVLHGSCFDSNQARDKTQNMLNPAFDGKRGLVPDDEGHVYKEYVDQDRWDTQRITAAAMASAMVDATNSVAYAAKQSVHLYPTTGCASEHGNYRARVGKRNKDIHGFTIEFGDWNTQAVCPFYPDADRHRTNLIENAVGFMELLISAARMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEH2</accession>
    <name>A0AAE0KEH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_481591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEH2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="90" mass="10353" checksum="B942CAD88082CAB2" modified="2024-05-29" version="1">MDNAVDQHDIERLNDKDKAELRSFITNEQQRTRIQSQTHNLTDMCWKKCVTGPIKSGTLDKGDSTCLANCVERFLDVNIATMKHLSNMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEI4</accession>
    <name>A0AAE0KEI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_419958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEI4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="317" mass="35589" checksum="09FE9F2849952FFF" modified="2024-05-29" version="1">MDRTLAKNNEPAIHPSRLSGSKKRPHAEAEDNTAVAYGERARSGPSRHNGHNAKRAKVIDDKMSSIKKRARAIERLLARDISNIPANVQNDMERELAAHKQRIAEDKERRHRSEMIGKYHMVRFFERQKAIRLAKQQRKKLTQLHKPEEEAKLKHDLHVAEVDVDYAIYFPFLERYISLYAAPAKAKETEAKAEKPTAVIALHIPRPPIWYEIEKAREEGKIALEKIQNRQSEQEAPPKPAFKKQKVMRPPAKNQFAAADSSSAPARFGAPSASATNRRERRAAMRKATGSAKAPVKADTAAGDGNDSDGGGFFEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKV1</accession>
    <name>A0AAE0KKV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_399078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="22145" checksum="CD7D7BDFC98528A0" modified="2024-05-29" version="1">MANFRRFRPDDLNKLSKCNLDPLTETYELGFYLQYHAKWPALFQVAEDQHGNIIGYIMGKLESSPDVYQFSEHYLPWHAHITAVTVAPEARRLGIGKLLTEHLEAAADANNAWFVDLFVRRTNLKAIAFYENMGYSIFRVVKDYYGDHSSDPTQTNEDAYDMRKPMKRDVKMEHIRDDGEKHEVDPADVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKZ0</accession>
    <name>A0AAE0KKZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SepA/Bni1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_238544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="256"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1556"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1526"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1627"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="979"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1583"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1674"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1724"/>
            <end position="1744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1744" mass="193878" checksum="30E5158AB32F8920" modified="2024-05-29" version="1">MSSHDKSRASSGGGKASSFFSRSRKADKRNTSDEARYLAVDHDASSSMTSRSSSRHARESSVVSVERPHSPESGINMTAGIMTTIPYESVSGERQSPIPIHYLPKTDQMPIRREPMSHQYPSNFDPSASNASFQPSGPRPPPTNNITMASTGRQTQFHQWGPPRDSTAAGSHNSKYNSYLTTSAARSSADNSSILSGNGGSVYDPSSAYRGSNLGQQPPPSASSQSSYHSQHSHRESHRLTKLPGGHQSSEGFVLHRPDDDRATEHMFLSLMQKRGWHNLPDQAKRQMMAYPASKKWTLIYQDALTEWQGEQKRRQTARIGQYSSVDLLQSSDEEGSPEWYVRKVMDNTLDSKGLASLEVILRTQQIGWVKRFIECQGQVALTSVLMKLNRKTALGPAPDSVKGDKNSDREYDIVKCLKALMNNKYGADDALAHQQVIVALATALISPRLTTRKLVSEVLTFLCHWGDGNGHLKVIEAMDVVKHQLGENGRFDAWMRLVEVTVDGRGKMGSLVGASDEVRSGGIGMENLLMEYAVATLILINMLIDSPENDLQLRVHIRAQFTACGIKRMLTKMEAFQYDLIDKQIERFRTNEGIDYEDMLDRDNSSIKDSVEGEVKDLNDPVQIVDAIQQRLKGSKTQDYFISALQHLLLIRDNDGEERLRMFQLVDSMLSYVAMDRRLPDMDLKQSLNFTVQSLLDKLHTDSEARQALDEALEARQIADAAMAERDEMSERMALGADGLVAKLQKQIDEQTRFIEAQSRRTEGLKSELESLQSLRTKEAQRYELETRELYLMLRDAQDVAASNAAKISGGNKLGEEDPVRMQGILNRDRLMERLQRQLERQKTQYKLEGRTWGETAGPSDRLRALREEMDEGFSEPAPGSGAPPRDFTNSMLGSVKRSTRIPRKPVNSRGEPVASVMEESDDAAEDEDGVVYEKPRLVEIKRPVLDPKQAAGMFGELTGKIKRYDASDSEDGDGVTTGPSHPSMESQSPVTPSDNEPPKIQITSASSPSSGPPPPPPPPPPPFPGQIPGAPPPAPPPPPPPMPGQIPGAPPPPPPPPPPPMPGMLRGGPPPPPPPPPPMPGAKGMPPPPPPPPPMPGAASSGHFLSPQQSYSATPSIGLPVVRPKKKLKALHWDKVDSPLTTHWAAHAPSAEEREEKYLELSRKGILDEVEKLFLAKEIKKLGGGNAKKDDKKQIISNDLRKAFEIALSKFSQYSVEKVVQMIIHCDKDVLDNNVVMDFLQKDDLCNISDNTAKLMAPYSKDWTGPEANKENREQDPTELTRQDQIYLQTAFELHHYWKSRMRALALTRSFEADYDEISEKMRQVVTVCESLRDSVSLMNVLGLILDIGNYMNDANKQARGFKLSSLARLAMVKDDKNESTLADLVERIVRNQYPEWESFASDIAGVMAAQKINIEQLQADAKRYIDNIKNVQMSLDSGNLSDPKKFHPQDRVSQVVQRCMKDARRKAEQMQLYLEEMVRTHNDIMAFYGEDPTDDNARRDFFAKLALFVSEWKRSRDKNIQLEETRKRNEASMKRKHAQLKATAAVGESAPASPTSTGAMDSLLEKLRAAAPQTRDQRDRRRRARLKDRHQVRVASGQQIPEFNEIPEVEAGLQTITSPDLSVRAEDDGNLLSPDMLSLTKEAGPDEDDVAKRAALLLQGMRGDGADDPADAEKRESLRKSRRQTADEERRTRRRRREKAQSGVSNGDGARDESMPDVPSLPNTPTSEEFTASAANGQSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLN9</accession>
    <name>A0AAE0KLN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_479983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLN9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="135"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="314"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3378472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="522" mass="57613" checksum="ADE3ACB70125CE64" modified="2024-05-29" version="1">MTSTSPKVSPFLEPGPYTRANSLAILQLSRDNLQPVYLQPLSGDHDGYAEGAVVNTRYGSFPHSTMIGIPWGSQIRASKVDTGSRGRKRKRIAGDEATAGQPETPGSNENDAETESASRPDAASDSKKGLGEATGFIHILPPIPEIWTMSLPHRTQVVYTPDYSYVLHRLRARPGAVIIEAGAGSGSFTHAAARAIYNGYPTRAAKRKGKVISFEYHEQRYHKMKKELSDHGLEGIVHLTHRDVYKDGFLVDGKSPEADAIFLDLPAPWDALRHLSRRKPPQQSSSLSDDDGANNTDQQIKEDDSQWVSALNPKKSAYICTFSPCIEQVTKTVSALRRLGWVDIDMVEIANRKIHTVRDRVGLHLPIDRGVNCSPKDVEEAMAKLTEIEDRFREHSRPKGTGDDMDLADDEPATNGAGAMVDGGDVDGEVVPSTQAWMDGRLVTRGEPEIKTHTSYLVFAILPREWTEEDEAAAAAKYPCGAEVKVVGSIDKVSRKKERREMLEQQGGNRKARRKERDEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0N5</accession>
    <name>A0AAE0N0N5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_513596</name>
        <name evidence="2" type="ORF">B0H63DRAFT_515820</name>
        <name evidence="1" type="ORF">B0H63DRAFT_515824</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000014">
        <property type="protein sequence ID" value="KAK3366348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000013">
        <property type="protein sequence ID" value="KAK3366357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0N5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29467" checksum="357E1E349BC179D0" modified="2024-05-29" version="1">MPPDKNAAARQMAQNLTEDELCNYVDSLAYQDGNCIYRPAPGKPGLFIKYGFKALCAEGRMQQLAFEFLRKAHTTTPPTLTNIHVPEVFSIFTKGEEAGFTIMELVDGVEAEEYMKKLKLDYAEPRTPLYDLIAHGVLSLCNVPVPPDAYPGPYLYTNAENTRVKSRIRHMIFQDFHSPRVFQTIQEPEEFLNAIGKWRAQTNPGVLTSVQLEKELTFCYTDFNEANFMLSAGADGRTHLHIVDFGHASFLPLSLMAYVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0S3</accession>
    <name>A0AAE0N0S3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_498183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0S3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="637" mass="72462" checksum="036CC227C04C9A42" modified="2024-05-29" version="1">MARCRRPVGDASDSDVSFSPEEDELFDIEDHRDDSTEPTDIEDLGEDDNDDDDDDDDEDGNKLFGGNTHPPVYYLRGMDDSDDSESDGEDYSPGSERQLNEVEGLWQHSLGTRWKVFRLVYERVMGEKLDGKLNRKMHKVLEKLAKKHGLSSKRRENRCMTIDTLKEEIHTTLSTTKKSFDLGELRILAVLFLLLLAPAGARPTSILRLRFGDIQVMVTRNPGGGPYNILIWFTLKFTKTYLGEKDAKSYPIPEILHDPSLLLSPHVFLLGILFRHRVFRSPMLVSAKQLHHLNIHPGEVELLLPFRADMEDVCVFRRAVKTLTGYEISTTEPIPYGMIAAWIRRIGEILGLAYQTIPSDISESLRNLALDHANSVPFQKHYLGRRICADPWGILRGQGPQQALIKQSCGIGHSISKRRPVDLTPEQARSVNNHPEIIRLTKRLEGIPRGLRSEKERLKRELKNTIREEWTENQAVIDIERQLRGQGFEDVPVDASCPPQRPAQKRLVETLTAPDDATLEGYYRRRYNAIDAIAAYCFVQEGRTARHITHRTTTTKPTQPSHAGEPPADSPLHVAALSVFVNTLSLEAGDHRIDELIHEYFTSGDLSKHFRRKHLLHLRDGDKIHPPSSLLRKILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1X4</accession>
    <name>A0AAE0N1X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_529565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1X4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="21480" checksum="5A0381E3ED63CF3B" modified="2024-05-29" version="1">MATTTALFVIDIQHDLAVDPDIRVPHADRIRAAGAKILSTARAILDAHRPGASSPPPAFIVFVQHEEQPEQGPLVRDSAPWKLVFEPRTDAEEELLIHKTTRDTFETNPDLAAMLTASGVKEIIAFGIQSECCVESTCKGALEAGFGVTLLAGAHSTYDADGSSAVEIERAVEGRLQESGARIVPWEDAVAAWEEKGQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2E2</accession>
    <name>A0AAE0N2E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2E2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11811" checksum="7F62674B5BD340A4" modified="2024-05-29" version="1">MADMDDYDIPKEVPASADTERDPDSVVRGHKAAINNPNIFDKAKAHSRQVLETYGEPYEPSNPSQKTSSNADGKKDPGNVARGLKASISNPGVSDEAKQRAQEKLDAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3B2</accession>
    <name>A0AAE0N3B2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3B2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="215" mass="24371" checksum="73D3C7C4F5CE424F" modified="2024-05-29" version="1">MEDPPLSVAASITGILTFCATIIAFIYVRYSIISNGYAEISKIMASVKSDGALAITDPTIEEDLRPGAVQMRKLISDFRENDHTILLKLLKVHGVNISGTDSGFAVVGTEAQESYQPARTKSMMFFRALRSCATAFGKWVDWLEIFWGFWRFSATVALGGTSATLLRWYVVREEVMDMVERRNLLRSQIQYQQMALLHMDLREIKSELSRWKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3F6</accession>
    <name>A0AAE0N3F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_490094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3F6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042259608" evidence="6">
        <location>
            <begin position="22"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="10">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="230"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="8">
        <location>
            <begin position="690"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="9">
        <location>
            <begin position="781"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3367979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="889" mass="97653" checksum="0F80D040DE958A46" modified="2024-05-29" version="1">MHLTAAALALSLAAVLGVASATRRLVSSAGQTAAIPSWDLQSSAKAGSDLAALSRIDVDTSSWHHVGVSRCTLMGCLLESGVYNDTDLFYSNNLSKVDAKQFLVPWLYRKEFALDPAPGKHFLLQTHGITSRADIYLNGKQVADKSFQAGAYAGRTYDITSFLEKTNALAIRVYPTSYFYDFGLGWVDWNPWPADNGTGVWRDVEIKQTGAVALGPLRVVTQLGTTPGSQPANVTLKARAQNLEKAAVTVTATGSVAPVSGGDAIVIRKTVTIPAQTTVDIVLDTVVAKPAIWWPRQWGEQPLYQASITVATADGALSDVAANKFGFRTVKLTRTNSFNDSQFWINNKPFLVIGGGYAPDMFLRSDPAKVEAELKYTLDLGFNTIRLEGKNEHPELYDIADRLGIMIMPGWECCDKWEAWKYNNDLAVPTPVWTSDDYVIANNSMIHEAAMMQTHPSVFVYMTGSDYYPDEKATPMYANALKEADWQLPAVSSASKRGDTFTGPSGMKMEGPYDWVPPNYWYDTEPAVVESRFGAAFGFNTELSPGAGTPDLSSLKRFLSKSDLDDLWKNPTKPLFHMSTETSSFHTRTIYNAALWKRWGAPTSLEDYVLKVQISDYEAVRSQFEAFSALWNAQRPATGVIYWMLTGAFPSLHWNIWDYYMHPAGGYFGAKIGSRLEHVAYDYVRKTVSLINRSLDRSGSRVIQVQVVDTAGKLISNSSTTVTTTPNTSKSVVDLTKALKDIKDVVFVRLLLLDTSGNVLSRNVYWLSKAIDVLDWENSDWFYTPVTKYSDYTALNKLDPATVTAKITKGPAGTTVLLENQSSVPAFFISLNLVDSAGKDVVPLIWSDNYVTLLPNDKVSLTVSPFAGAAVPAAIEISGKNVAKATVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3Y2</accession>
    <name>A0AAE0N3Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase Family 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_304532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3Y2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3369941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45059" checksum="18F44249733B2963" modified="2024-05-29" version="1">MSSILRRPLLRARHLVVVVILVFLVCRLWIYPPPLSHSWLSLPGNRKAAVVPTNSTLGFGRIYVISKEDSPRRPGLLQAANVTELDLTIPVQPTWTKVDLEGHDGIGRGSVLAWLGHLHSLRQFVESGVETALFFEDDVDWDIRLRSMQAPLVATAVRTLLAPKPDPTGSLNTDAHPNSRSDPKRYPYGDPAAWDLLYLGHCGDYWHSTGDGFEKGHVKPEDLTARPHISFNDSSVPDPNNLHPWTASLLENLGVPPRTRLVHSSVFPLCTFAYAVTRDAAKHMLKHLSLEARADDVVAYDVAILHQCRSSSGLRCWTINPELFHHMPGKSMISGIDNHSNIPPVDATGREQAEIRHESPNIDCGFWSGAFSFKPNDKRRLNHLRREVGRKGRCLKPGRDLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4V6</accession>
    <name>A0AAE0N4V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_314724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="160" mass="17640" checksum="84DBB74DD31203FB" modified="2024-05-29" version="1">MTSITSHEMDKQGLTVETTMTRLTEQPSQDPFGSDTYTPLAEKHTRSSDVSTPGSSRANPFDTDIEAIITASEHNTRKSAECTKGGSDCQVWPGKDHWRQKAKAAKRNRHSCNCLSRLSKRNRIIVKILIGLLIVGIALGVGLGVSRHLNAPIWRSETQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5V8</accession>
    <name>A0AAE0N5V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_513484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5V8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="355" mass="41559" checksum="C55D356F9353169B" modified="2024-05-29" version="1">MAPRTRAQRQHTSTTRTSVNTTTDSAPSLPDCESPDDDDRGPSRSINKPGEEDAREEELEKVPRLVHAQVLGCRMRVPLTYDPDTYDPDRPVPWTPEPEPYDAETYAAWGRKHFGEEWCKLREAMLREGNIYRVLPRVQPPRTASTAPIYYDDSDLSGISTFPHTPEPRESSPPLPDDPWESLEYERKRYGWSEEEYQWERIFRNEKRIDWARPRHENQEGGRQREKELEDIEKVRYIPGTEYISGEYERRMKKFNLRAEGWTQEQVDAEDRRIVAVRVAYAEEKPQKIFRENKPMTERLVYRFEVAGVSRERQEELAQEAGHELASETEEIEAEEISWKAYGLDGNRAGRGPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6R1</accession>
    <name>A0AAE0N6R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_484046</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3372193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="279" mass="30405" checksum="D42E4B9E5EDB28DB" modified="2024-05-29" version="1">MPGWIPKDTLHFSPEDRAFLEPHLPPRDGSTPKPDLPFTTLTFATSLDSSLSLSPGVPTAISGPQSKAMTHYLRSRHDGILVGVGTAVADNPSLNCRIAGVGGYGSPGFDGQPRPIVVDPSARWDFTEESKLFQLCREQRGRAPWIVTALADPPAEKKALLEKYGGCYVHMDIQATDTGSHRLDWHELLVVLKRRGLRSVMIEGGAQVINSLLEPRYKSDIDMAIVTIAPTWLGQGGVVVSPQRRFDDAGTAVAAVRLANPKWYPFGEDVVLCAQIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N735</accession>
    <name>A0AAE0N735_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_300918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N735"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="658" mass="70787" checksum="6D280596A785BAE0" modified="2024-05-29" version="1">MAYNYGPPPPPPAASPPGNAPAGYPPAYGQSYQQPSHRGGHGGHGGRGRGGHDRGGYHQQSHAPAPAYGYPQQTGPYGPQNPAPYAGSHAPQQGGFQTPQQAQPQQQWHPEQHAAHPPQHPQQPPAQPPLPAQNYHPNYAPQMYQQHPQPPYAGQPPFQPQAAYNQPYPAPVPQQGPPAQQWGAHPQAQTPNHYGDGGGRGGRGFNGRGGPKGQLMGPPIRIGFDANVPQGPAPVSSPYAPQPYGGPPQGPPVAYPSAPYQGYPPPAPYMPAAPYDAHPSHSAPRHNGRGGFHNNAPSKSRPPFGGGDKMRNRNNNNNNKVPSGPTAQTPPTHHQKPDAASAGKKKKRKTNTLGLTPGDESDEDDENEEERLNEMYGADAPNPMNSSDIQAWIAERRANFPTKAKVEAKKNSGNNQNGDASRNGEVKDSILERQQKKAEKLRRELEKVESSIKRKREQQDEGDEMRDVDMSSSPSSDSKSEDDEKPEVMSTRQEPSYLPPPPKKADPTKHCKYYSTGGTCGKRGKCRFVHDSSVREAALREREMNGGRMTLQQRLTLNDKEQEDLTIVQTLKYLSDKGILKKELTAKAAAASAAASNAQQDPKPASTSLPPNPIKKEPGNGLPPIPPPSAVPANHTASKYSGWNLSGFGNTGVRSGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N908</accession>
    <name>A0AAE0N908_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0H63DRAFT_399890</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1071"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1110"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1153"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1189"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1218"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="241"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1039"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="986"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="992"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1013"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1017"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1017"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3375236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1367" mass="152755" checksum="7C47C737EE4ECAA5" modified="2024-05-29" version="1">MAARPPPPGGNSNSNSSPNPDSRNDLLLDLDNEQPIYHSGQRSTLNDDDLLAYGYDQDGAQPRPSVSYDDFVGAGGRAAVHPSSIPPPAASGPSGSTRRDAPSGPYLTDADRQFSQTSDLGNYQRYADDDDYPDDGGSYYQQGGALPGGAAAAGRGTARNRNSVLSLGGGLFGRVKNKLGMGQGYSEMDLPLTESRAAGRTDSDGLDPPPSKPAKKFDMGNFKFGFGRGKPDPSTLGPRIIHLNNPPANMANRYVDNHVSTAKYNVATFMPKFLFEQFSKFANIFFLFTAGLQQIPGLSPTNRYTTIGPLIIVLLVSAGKELVEDYRRKQADKALNNSKARVLRGSTFNETKWINVAVGDIVRVESEEPFPADLLLLASSEPEGLCYIETANLDGETNLKIKQGLPETVTMVSSSELSRLGGRIRSEQPNSSLYTYEATLTMQAGGGEKELSVNPEQLLLRGATLRNTPWIHGVVVFTGHETKLMRNATATPIKRTKVERQLNMLVLVLVGMLLVLSVISTVGDLIMRKVEGDSLKYLFLDPTGTASEVARVFIKDMVTYWVLFSSLVPISLFVTLEMVKYWHGILINDDMDIYYDVNDTPANCRTSSLVEELGMVEYVFSDKTGTLTCNQMEFKQCSIAGIMYSEVVPEDRVPTMEDGVEVGIHDFKQLEKNRRSHQSAEAIDHFLTLLSTCHTVIPERDEEGNVKYQAASPDEGALVEGAQQLGHKFFARKPRSVIIEVDGKQLEFELLAVCEFNSTRKRMSTIYRCPDGKVRCYCKGADTVILERLNNNNPHVDVTLRHLEEYASEGLRTLCLAMREVPEHEFQDWMKVYDKAMTTVGGNRAEELDKASELIEHDFYLLGATAIEDRLQDGVPETIHTLQEAGIKVWVLTGDRQETAINIGMSCKLLSEDMMLLIINEETAEATRDNIQKKLDAIRTQGDATIERETLALVIDGKSLTYALEKDLEKLFLDLAVMCKAVICCRVSPLQKALVVKLVKKYQKDSILLAIGDGANDVSMIQAAHIGIGISGMEGLQAARSADVSIAQFRYLRKLLLVHGAWSYHRVSKTILFSFYKNITLYLTQFWYVFQNVFSGEVIYESWTLSFYNVFYTVLPPLVLGILDQFVSARLLDRYPQLYNLGQKNAFFKIKVFGEWILNAVYHSIILYVGGSLFWIHDGVQSDSLVAGKWVWGTAMYGAVLLTVLGKAALVTNNWTKYHVIAIPGSMAIWLVFVAVYGIVAPKLNISTEYFGVIPRLYASPMFWIEMPTLAVLCLARDFTWKFSKRLWRPEQYHHVQEIQKYNIQDYRPRMEQFQKAIRKVRQVQRMRKQRGYAFSQADESQTRVLQAYDTTQHRGRYGEMASSRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBX3</accession>
    <name>A0AAE0NBX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_244660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBX3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="13">
        <location>
            <begin position="227"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3378327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="589" mass="65757" checksum="9857C7E034A015BC" modified="2024-05-29" version="1">MALDFPVIYLLAAHLDSDELAQLEEQIPTLTYDVNEADIILGKIFRKGRALFELRKLRLATEEVTPTELPVASQHERRSSVDSDTASDGGASVVELNSTTTKTIKVVKLAWFTDSIKAGVVLPVGAFVVYEGRKVSTPSMKPPPTPVAKTSNILKHAITDTEAPAAKRPKSSYGPGRRNDEYVHRPAKRPALIHQTTSEHEVYVQLPPIPEYLHTTYSCQRPTPIRPPNEKFIQELIKIRTARTLNGDKVGVRAYSSAIAALAAYPHTLSSAREVSNLPGCGSKIALLFQEFKDTGELKEANDEELDPKLAVMRLFYEIWGVAETTAREFYNKGWRDLDDVVEYGWGSLTRVQQIGLKFYDEFQLRIPRAEVESIANTILEHANRVRKGFQMVIVGGYRRGKLESGDVDVVLSHPDEAATNGFIEDIVVSLERDKFITHTLTISTKNSERGQMPVAWKGNQKKAGTGFDTLDKALVVWQDPKWSSGEVKKNLNPHRRVDIIISPWKTAGCAVLGWTSGTTFQRDLRRYCKKERGLKFDSSGIRSRSDGSWVDLESGADGQPAPDMLTAERRVFAGLGLEWRPPEERCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGY7</accession>
    <name>A0AAE0NGY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_524055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="29444" checksum="742C84DF0BDBA812" modified="2024-05-29" version="1">MAQPQYSSDNNTSRAPAEASRGTFRPPGQYQYPSAGFENPQGYGGPPLAQALHRNHVLLPRAAALHGLEKLQKVFRANESNNPGPVDLPATGEIQQPFITPLGLVSPTKYVDLVASLERHEITARPMRMLVLDDDVPHNGIDIHFGRPFLEEYGARLLLVPSVPAASNSQANVWQSSYVGAQAQASTHLSTATSGSSQGLDSSPSVTTITSEGTPNSTSLVGTLSTGRDRYHYDPINRYIKNPPSASTLLLPQIPYGSLPTPLIPMAARWTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNV2</accession>
    <name>A0AAE0NNV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_472035</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNV2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="399"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="652"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="748"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="879"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3384964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113273" checksum="B18CB9991F9C3EBC" modified="2024-05-29" version="1">MTDYSMYHALGQGENIDPNDPNRTSQPAPPQFQPPVAANPYQQSPAYGAPPPGQHQQQHQHFGGIPQPGPYWAPAPGYGPSQPQGQAGYFQGQQQQAQTPDDGALAAQLGGMSLGAEPYGGTARRKKKDRHAYHQVDAPAGSSQPFNGMPPAGTPATAYLNADPSLFPGGATPQMNQFPAPANPQFNPAAASPAEFGARSGLGEAVPSPGVFAASGQGKVSPDDMPSVPISRDSVQQYFLSNIYPTFERLVPPPATVSFVAVDQGNSSPKFARLTLNNLPATAEGLKTTALPLGLLLQPLASLQPGELAIPVLDFGDVGPPRCHRCRAYMNPFMMFRSGGNKFVCNLCNYANDTPPEYFCATSPHGVRIDRDQRPELTRGTVEFVVPKEYWTREPVGMRYLFVIDVTQESFNKGFLESFCDGILGALYGGAEAEELDENGDPKRRIPAGAQVGFVTFDKEVHFYNVSPALEQAQMMIMPDIEDPFVPLSEGLFVDPYEAKSVISALMTRLPQMFSNIKNPEPALLSTLNSAVAALEKTGGKIFCSLSALPTWGPGRLFMRDDGKHPGGEPDKKLFTTEHPAWRKTAEKMVSIGAGVDFFMAAPSGGYLDIATIGHVSSTTGGETYYYPNFVAPRDNTRLSLEIKHAVTRETGYQALMKVRCSNGLQVSSYHGNFIQHTFGADLEIGVIDADKALAVTFGYDGKLDSKLDAHFQAALLYTTASGQRRVRCCNIIAGVSESAKDCLKFIDQDAVVTILAKEASTRLANTSSTLKDVRLGLTEKTIDVLAAYRKNYLSQAHPPGQLVMPERLKEFSMFMLAMLKCRAFKGGNESSDRRVHEMRLIRSMGALELSLYLYPRMIPLHSLEAEDGFPDEMTGHLKLPASIRTSFSRVETGGVYLVDNGQQCLLWFHAQTSPDLITDLFGEDKTSLQSLDAYTSTIPVLQTHLNAQVRNIVEFLKTMRGSKGLTIQLARQSIDGAEYEFARMLVEDRNNEAQSYVDWLVHIHKAVQLELGGHRKKEDSSEGSALSNFTGLRPSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNZ6</accession>
    <name>A0AAE0NNZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_449128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNZ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="252" mass="28412" checksum="37CB350D2303E33F" modified="2024-05-29" version="1">MYRRQDLPGGTDEVIVWNVPSLVIAIVMALFAVTFCIVWIRSHRTVARLRVEIQRLERALAKSVDCRRFLESELERVNMLVQVQSNLSSLGPFDAPSSPESQLTRRSLTSGMAGYGGDIRSPLGELEEDLKRIMQDQQDPRRSSEHTATVGINTLDDDDLDDVPIRNVEEAARDFRRFPSYQPYDFHDDDEYEMPERPTTKNQLHAMPPVGELNAFEAAHAALHRPSSSDAISVVSQKSSRRSVSPSSTDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP09</accession>
    <name>A0AAE0NP09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_178535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20551" checksum="062BE8BB8045A195" modified="2024-05-29" version="1">MVVEDGILRYIRITLLVVRFCPAYLTRGRGIFLSFFFFLSFLLLLCYFSGCLQPAFVNYIRCTHANGRMPSLKGVQPQLRVARAGKVAPPALPAFWLALPELFSPFQETQGCRLAASLQGYYRRRRVFFFRFRYRNLEKATVPWPTNMLCDLPVSLPNLIVFTRPKDSEVADDRTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPP8</accession>
    <name>A0AAE0NPP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="275" mass="28946" checksum="7B2FB2F39D3D9615" modified="2024-05-29" version="1">MAQAGEKRFGPGGFLTEREVDTLIKGLLSLPDIDAIPQPRMDKLAARMSVVQHSATSAWSRLKRKLREHIAAEENVVPAAIRGRGRAARRGGGHGAAAAGRRGRGQVIEDENDEDDDEQAATRAPARRPRKSGAAAAAAPAVPAAAGRQGGRQDIEENNENDEEEPAVRRPRGSGAAAAASAVSAAPPAACRRGGYEESEEESEDDEDESTPSRAPRRPRGSGALAAVATPSQQRVGNTTPAAPRRSFGFVMESDDEECSNNGRAAKTTEQPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ80</accession>
    <name>A0AAE0NQ80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_414761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ80"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="40521" checksum="E8BB8123CC0B08A7" modified="2024-05-29" version="1">MLHLRGEASLTPDQVRVLGILTRTASTLSALGVIAIITTFVASRHFRNPMHRLIFINAFYNAFDVTCTMISTSGPQAGNPSALCQFQAFLNQMFPVADVAWTLAMAANVYLIVFRSYDTVALRKLEWKYAIVITVATFIPAFVFLFIRSDDKGLMYGSVTIWCAIAPNWVLMRIVVYYVPIWSMIFITIVLYCLVGLEIVKRRHALKSINSDSDAILLDETLRPENSAASPNHNSTGKTTAVEFDDAQSHSRQASTSHSESPMSTHHPQRLNTPRQSSALSFRQYILMPLFFFLALLSVWVAPTTNRVASFVNPSFSSYPLLLVVGTTGSLRGFWNGLVFVTIGMKSRKRRKDLEDVALHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQA0</accession>
    <name>A0AAE0NQA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_544119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="25755" checksum="863A8F0B14A66325" modified="2024-05-29" version="1">MAHASTGRNDIIDSFFDWVLSSSMTDVQIYASVPKVDRNNSGSSTSRAADPSLYGTLVATAHPNGAVSADGHHQGSILAWSPPPPPAPAAPGYSNDPSYGAGGDGSSGGGGYGYQQGYDYSGGAGATYFAPRGDPSDQHRSGGTHSYSSRTAHPHVSAMTAAVNKLSLGSSRKDDVGRPSTTSSSGARTSRRDRDDTSQTGNSSRRETDSYRSSNISSKPAAASSSRYETRSSSCISGTTKRSSKSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQY6</accession>
    <name>A0AAE0NQY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_544670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQY6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="447" mass="49721" checksum="91255D884E20A13E" modified="2024-05-29" version="1">MTLDLNLTSLFSSRKMPAKNLPHDGLTRNQRRNAQKRKLMFQVAELERQAAREAIAKNLAAEKKGTSAPPSPPRAALSSSELFFCAASATAAVKNGLSFRQPSAAAAETEKVALPTMPAGLKRGIPFLPGEPRTMYGKKKKLDHRRIIKDEKKVKDELPIRVKDDEPPIMDLARTPRFLGELPIRVKDDAPPIMELTRIPRLPGEPSSSAAAATTTALGTPIPFEVHIISAMLDAQYAKQLRQYMRTHGWSADEVTATMTMLLLPKVTPLATTSPSLAMNLLLDIGETSYGELSFSPLAVGGSATIAIFKQMDDLLLPLIDERRIADAISGWRPSVVCSLSSSSSSGCRRPRQPPHQTHKIAAQRHIDLQQLLNIRRGRRNRLERRTFTREGEEWAANALGDLVEMCMRLEKYGMMTHYFAKSNARLCEMKEVEVEELAKFFKYVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS10</accession>
    <name>A0AAE0NS10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_382316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS10"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="289" mass="31879" checksum="99743FFCF661A058" modified="2024-05-29" version="1" fragment="single">FDSNDFMKIDPTHGFVDYKNYQDAHDGGLIKTQGTELYIGVDSDHNGVAGRGSVRLESQTRYNKGLIIAHFTHIPKAVCGAWPAFWMYGPNWPNSGEADVYEQWNLADPLYAFHTGAPADVGACTLKPSTFSATQGSNNCYIHAQGQFDNEGSALSLLSSIEKVTNRPLTDATQWTSTVFRVWTWPANKAPADALSGEPNPASWGLPTFSVDSSSCDIDRAFKDMRLVLNIDFCGDAAGNEGLWGWTTNNLPGYCSGKTGYGWCPDYVNSHAGEYEEVYWKVKDIRVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS79</accession>
    <name>A0AAE0NS79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_392320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="350" mass="39862" checksum="8B763375BDA46CEE" modified="2024-05-29" version="1">MATDSRDVEQKLDDALLAVLPDGGNVVSVTPSGMSEYVHTYRIQVSMPDGSSQVFFQKEATGSNGYELMEAAFISESTAHEFIPEFLPKPVTMGTYKSRPNVHFFLSEFVELIEDDIPDPEDYMAPIIALHMRSMGRSPYGPHQWGFSNNTRFGDLEQPNEFKGSWEEFWTGQMKMFLDREEERRGPPDAEYAKLRPLFFEKVLPRYLRPLETGGRSITPTLIHGDLWPGNVRYKTDDTVCAYDSCVLWGHNEVDLGVFRNPRYPLGKAYLKEYWKHVPISEPEEDADSRNNLYMLRNQILLAILYPHDHKLREVFVSNMKLLVHRVLAEEAAAKGSAESLGGPGLQAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSH1</accession>
    <name>A0AAE0NSH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_391816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSH1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF4">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="62"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="9">
        <location>
            <begin position="400"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="88601" checksum="44121CBFE7CD78F6" modified="2024-05-29" version="1">MRQHVEEERRLSERLKTQNGTGLSSAAADLRVLQLKYDAMRIAGERPARSTSGLLKAVCSTDLVFLIDATGSMEPYIDEARRQVRRIIDDIKAAVFDEAELRVAVVSYKDHGWGREDHYDVLDFTTNPDNVALWLNGLRASGGADQAEDVLGGINAALNLPWHHRTRCIIHIADAPPHGSVLNDLPANAGKDSYPQPGMEPHGLTYEPLLRRMVSLNVNYALLAINSSTDKMAYRFYQIYAEHSRDCKLLPKNHYYQFTRIPPRCAIESGLLFEEYSFSENPRDLRRLVVKNLTTATTHSAALSSVTLDGDKIVLGRRYGTPGGLEPVAEEENENIKEDEHGGEGSQPKSGSNSSQDASAAFKLDTKPPRWHDPNWLDEIFHAEAFSADVEVHKPDMLNAMMADDDNIKIATMDLTIRHQSRPFAQGAQRLVAYARTAASTSPLVVKSFKRGGRGGKGLAQLVEDMRIRALCKGFAVEFNALVSSSSLPSNNVTQQQQQLIDFIAVICLKPRFFFDPGNEENDEPECLALEPFLEGKYVKYNSNSGFVSQDPSLQNFNETAQAFSHFTFERSKGEFLVVDLQGSATNGLLTDPAIQTRDPNRFKLSSTNLGGAGIKFFFATHKCNRVCYQLEFASNRDMISSGRYIFRLSWHPYVTSPARPVVTMACCSNKLCSRIVRTTATTRAGAGGGGSRVSGGSNSSNSNKRDDNGHTTSESINDVDGGPSYHWCDACWWQLHETTETRLCVVLISSMNASGGRHHHEFVVSRFFYESQNKVVPGRCPKHRSSSAAAAARRVVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSI8</accession>
    <name>A0AAE0NSI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_558490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSI8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041970760" evidence="4">
        <location>
            <begin position="24"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3386881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="571" mass="60608" checksum="D4048DA465E0EFF6" modified="2024-05-29" version="1">MHVHSKLAVVGAAVSLWFQPGAAQTCANVSTTQTYDYIIVGSGAGGIPIADRLSEAGHSVLLIEKGPPSTGRWGGTMKPKWLADTNLTRFDVPGLCNQIWADPSGVSCTDVDQMAGCVLGGGTAVNAGLWWKPHPDDWDTNFPTGWQSKDLAGATEKVFSRIPGTTAPSMDGKRYLSQGFDMLGGNLGKAGWKFIVPNDNPQLKNRTYGHSTFMYSGGERGGPLATYLVSASSRKTFTLWTNTVAKRVVRTGGHITGVELECNGAGHAGVVSVTPTTGRVILSAGVFGSTKLLFRSGIGPTDQLNIVKNSADGPTMIGNDSWINLPVGYNLNDHVGTDIEIAHPDVVFYDYYGAWTKPIVSDTETYLTNRTGPLAQAAPNIGPIFWEIIKGADGVLRHLHWQSRVEGTLNTSMTVTQYLGTGSVSRGRLTITRQLNTVVSTPPYLHDENDKAAVVQGLINLQESLASVANLTWITPRSNVTAAQFVNSVPATPSRRGSNHWIGTAKIGADDGRTGGKSVVDLNLKVYGTDNLFVVDASIFPGMITANPSAAIVIVSEHAATKILALPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSV0</accession>
    <name>A0AAE0NSV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_148227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSV0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="37500" checksum="D52D69D6AC331497" modified="2024-05-29" version="1">MAPSVAIIEEQTESPPQPTPRPSSSVTIEAASPMKTANPTSTSSSPPAIIAADKEKTPLEAISLGDVLPGIPSFPNFVASRRHILTHMAATFRGWARWGFTEGQSGHISVRDPEFPGCMWMNPLSRHFGMLTVGDFLLLEIDAGRIVAGGKNPTTELRTANAAGYYIHSAIHRARPDVHAVCHAHTRAGRGWSVFARPLEMLTQDVCNFHDAHAVYANYGGIVFGSEEGERIAAALGEKNKAVILMNHGLLTVGETVDEAGFLFGLLDRSCAIQLDVEAACAGNPGLKKQVISDDEAAYNCRMASEKHALYREAQADIELEFELAGGEEVLARGFESLVIDLADRAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT02</accession>
    <name>A0AAE0NT02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_150486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT02"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="502" mass="54041" checksum="2D31D06BA493DF10" modified="2024-05-29" version="1">MQYKMSYAREQSAAAPRPPAGTGAGAAAAAAAAATAGKQSTISKQQRSNSRPAAAEGHFDPDELSRRLCMVLADQKAHAERKRRARAAAEAGSSKGAKENNSNNNHRHHPHTSESSSKSHKPAEASTDLISELRRSRSAKHSSHHNNNNNSTDATGTATGDGGEPTEYHHVPNQAAKQFARTTTVDVMRENNVLHHLSGRALKFHIEGGRTVRPVTTGAATTTTTTEPMVAPAELSRVLRYNQHQRDKALDRNQFQRTRKLEEAAQMDAERRDVVEPLHTRHTFEGELSRISAEGGGGAAGIHHQLRNPQHHHQSSSTFNARRNSTGTALMTDLLLLDQQDHRDHRRSLIMMEPLAHMPDNNHHSAVDDTTPLDELQQRYPAHEHRVDWTQSDETKVVGSSSGGSSRPKLLLSPLLRRADSLWGLRGRLAGSSSKGGGGGAASTSSPSVAMATATTAATTTNHAEKGATVSSESRTAPPVPAVLVSPKSLKGSGGFFAKFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT26</accession>
    <name>A0AAE0NT26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_152958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT26"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="23181" checksum="ABA8768FF88468E4" modified="2024-05-29" version="1">MFDIELAGHVPKASARGASVIWKEELPALGVGAAHGPRQGTKYRSGPCISMIASNLPGMFYASPHSRQEARLARNASAKASVWFIRRQTVQSEQAQNSLMMRLKSFTKKLQEAPCCQNLWSGDEISPTCVNGLFEAHGPRLPPEILRHFSVPLFNDIALNGLTLLIVQHEEPRLADRADGGIWKRGNLKLSVSISSANSYFVAAVYQHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT76</accession>
    <name>A0AAE0NT76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_468942</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT76"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3387030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="743" mass="80994" checksum="036E9D921D64523D" modified="2024-05-29" version="1">MLRQTLARSAWRTGKQQTSLASRAFSATATRPAEVELTIDGKKVSIEAGSALIQACEKAGATVPRYCYHEKLMIAGNCRMCLVEVERAPKPVASCAWPVQAGMVVKTNSPLTHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGADRGRFHEVGGKRAVEDKNIGPLIKTSMNRCIHCTRCIRFANDIAGAPEMGSTGRGNDIQIGTYLEQNLDTELSGNVIDLCPVGALTSKPYAFRARPWELKRTESIDVLDGLGSNIRVDSRGLEVMRILPRLNDDVNEEWINDKTRFACDGLKTQRLTIPLARRDGKFEPVSWEQALTEIAHAYQTLAPKENEFKAIAGELTEVESLVAMKDLANKLGSENLALDMPSGSQPIAHGVDVRSNYLFNSSIWGIESADCILLVGTNPRHEAAVLNARIRKQWLRSDLEIGVVGEAWESTFEFEHLGTDLAALKKALAGPFGKKLQAAKQPMIIVGSGVTDHADAKAFYELVGGFVDKNAANFLTEEWNGYNVLQRAASRVGAFEVGFVTPSTTVAETKPKFVWLLGADEFNPADVPKEAFIVYQGHHGDKGAQIADIVLPGAAYTEKAGTYINTEGRVQMTRAATGLPGAARTDWKIIRAVSEFLGAPLPYDDVAQLRDRMAEISPALAAYDVVEPVALQQLSKVQLVDQNKAAKSTGAPLTKVIDNFYFTDVISRSSPTMARCSAAKETGDPRTNFMAPGMEEDRPMGQVAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTK3</accession>
    <name>A0AAE0NTK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_470044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTK3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="29298" checksum="210EEF6B7903A111" modified="2024-05-29" version="1">MRQGNEFYVAGDPYTNSGFWGPPTSAVNFCEEDYVVTRYVAEFINTLTNLAYVYLAIRDARTPRRGYSSGGKQTGGGSQPPGLDLMSGALAAVGVTSFIFHATLKHSTQFADEVSMLVLAGALLQGVYCAGSSNGRRNGLITASVVATVVAMSAYYLQSGNFVVHLVMFSLLIHNVWPRTIYLIYNRTKAGPERSKLFRKFYTAVAWCLAAFALWNVDIEWCQAVRKLQAATGLPWSWLLELHGWWHVMTGLGAAAYIDLIRDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTL5</accession>
    <name>A0AAE0NTL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_521519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTL5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="104"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="961"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137336" checksum="F54404E96220255C" modified="2024-05-29" version="1">MEPQQTQPRSRPSFPHLHHIVPPLSQVPNRTANSTPVSSPGLFSPSLPRSNMSLPASQPASESTTPGILNSPYLHPLQTHKIRETHKANVEHDYTTGRKLINHYEIIEELGRGMHGKVKLARNLESGENVAIKIIPRFSKKRRLGKVTAMDTQDKSKREIAILKKIRHPNVVALLEIIDDPELKKIYIALEHVELGEIIWRKKGLPHICAYERRRVEREMRGEMPTPEEERYDRLIEQRQALKEAKRAKLSQVQASLNDYWSLEYGGTDDDDYQSHHSLSTAEVDPLPPSMEPLPYSLAESRSTSRAPSRTHSARSLSKAVFSHPSNSDLASILNEDDLETPGPLRSNPASSTALDGSMYGAYVEDPAHRGRSPSMADSVISHMSSLDFNRVHDPYVDDFSYVPCFTLEKARQTFRDTVLGLEYLHYEGVVHRDIKPANLLWTRDHRVKISDFGVSYFGRPVRDGEPDDTISESEARDFDNDLELAKTVGTPAFFAPELCYTDAFDDQPGQQPKITEQIDVWSLGVTLYCLIFARIPFLAEDEWQMFRKIATEDVYIPKKRLRPVDPSTKPDEKSLYQRVNSAPYRDDDELAYEEVEKELQDLLLKMLTRNPEKRIRLRDVKRHPWVTKGISNVVGWLEDTDPSRRTSGRKIQVDEREVARAVVPLTFLERAKSTLKKAVGKVIHPRSERAESVSSSRRRAASSAASSAGDSPVHSSSASHPRDARRKSIRPDDYFSGLSQASSEHPLTQSVVASPRDSCFEELSAPAAQPASSSASVTGPSSRQLYEAVANLNAREDFSRQHSPISSYQRTSTRHGHTRSVTNAFLTLTSGLTESQTMPTTPLFDGSLHDPSAALRKARDMRPPSADDATRARSVDRGLFASSDKRAEPKVALSTAIAPGNVHFSTPRPPQSSELTRAVEHVFSSPLTGYQHGQPRSDPNIIRQHMSLELDERPMTAHRIEDLSRSRTPPQRAYHSPESYDQTQQQKGQSREVDEVVSITCQQTIDAAPEVEPSRIPCPPSPGEDIFVQSPPPLSREETIATAVSSSSTSMGTTTTPLTSPSESMSPIYVIDQMTMKNSADQILAFQSDPSLPALLSSTSSVSADLEGEFLGNPGVVERSSVIDTTDSLTPPAFTKEPISGFPIDDDITGAVHHVRLGNAGPRASTAMSSNSAASQDQQADDEDSDSDEGLVMAKPKKNGLSKELHSMGRLVSGSRRRDTNASVGSTETAKKFIVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUP1</accession>
    <name>A0AAE0NUP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_413309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUP1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31277" checksum="2E695201D4C5D488" modified="2024-05-29" version="1">MGKITPRVWHITGANTGFGLELALKALKEGDRVVAAVRTPSKVPDSLRVDSVKVLQFDLSFSQADMNAYAKKAVDAFGGIDVLVNNAGYAYMGAIEETEDEQVKKQFDINVLGILRTIRAFLPTLRTQGSGLIMNLSSIGGLHGYPSNGVYCATKFALEGITEALAAEVTPFGVSAVIVEPGYFRTSFLSSVAATGGGGDNLAPENPAYEGTVAHEARAAFTAFNGKQRGNPVEGAARMWEYATGEGLFKGKEKLLRLPLGSDTGAQMRALSEDLAKTADYYEDVWASTDFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUU3</accession>
    <name>A0AAE0NUU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_413260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041914167" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3387944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="237" mass="25157" checksum="03A53A56E62573FA" modified="2024-05-29" version="1">MKFLSGLLLTAAAVEAHYTFPRLVVNGKPEDKDWSVTRMTKNANTKQGIENPTNADIRCYASGTAANVATVPAGSTIHYVSTQQINHPGPTQYYLAKVPAGSSVTKWDGSGAVWFKIFTTMPTMDKNKQLTWPGQNLYTTVNATIPTATPSGDYLLRVEHIALHMAAQPNKAQFYLSCSQITVTGGGNGNPSPLVSFPGSYKSSDPGIQVNLNAIAPDAYRPPGPAVWNGDAGGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXA7</accession>
    <name>A0AAE0NXA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_94963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXA7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="164" mass="18607" checksum="016B298FE135A3FA" modified="2024-05-29" version="1">MYHSRTRSRKVSNTIGFTVTYRPPEIEMIGDPISRSADIWSLGCVLLEMVCWILGGPEELKRFSREREAGSNGMVVDGFFSVKPVPSGSVEFSVKASVTRFMDDLRSHPRCSQFIRDTLDIIQLEMLIMAANRVKSAALAEHLERMHQRVIDIANSDYIRQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXJ0</accession>
    <name>A0AAE0NXJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_445634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXJ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="984" mass="107527" checksum="B7BF84C74CE1B5A2" modified="2024-05-29" version="1">MVHQCVSFLTAGRSIATWALPMASPASIAALPAELVVFVLNNLDRLKDISALARADRKLYNTINPILYKRAVSQGDVWPLAWAAHCGVTGTLRKALAAGANPNHQFVDGLPVDEWKRANAVARQAVAETGDSDVWETENECESNVDFEADESEHISDGDDKNDENALDTNQPLTSSSSDPWRSSVPYIPFFTDSDRDSDVSMDEITAPSDSASSTLDDHDHEQFVEPVVSGAGAVLRRFNPLHLAARAGHNSIIEILLDYGAPINAFSECLCDCTRLYGLLNAAECPENDHFPPSWSPLHIAICHGHTDTAKLLLSRGASYMMELPTDYGESPYLNHSATALHHAAAAGLVDLVRYLLEKGIQAVVDVRDDKTLTPFYHAYANRRWDTTVPLLLELGANVDVDTKLFLPYSTITPLGESCRMGNFEEADRLIDLGADVTRGYVSTTTGRGLSPLHMSSMPSAQPVSEIPVPRVYEERERGIRRMKTIAKLIARGALIDLKDCSGDSPLIAAAQHHNVPGLRALIKAGANIHQQNAVGRTALMQAIIGVPNPVASAQNGSSDVLAQILQELLAGGARLDDTDSEGNTVLHLVFKGANKSQAFQKGALRLLLNKPSVSALLEVRNKDNQLPLQVAFQARNLEACEVLVRRGCPRGGLDQAELSSMFEDALVNLGDQATLDFVLDLDVNGYLTSDPSLFSTLITKGGYFAVRAAHIISERGLPSLPPRDYTRLLCQAIRLGELFLAYSLLEAGADVNAPNAEGQYPLALFIRNTFVQSRLPIKASSAHQFLQALLDRGANHHVQFDPSSPERVLNRVIGLELEEALILMLKTQPLANDTRAANGFYLHGAVTITSGQRPSSEKIIDILLASGPDLGEINGDGDTPLSVLLKCLCKERRFTWRYHRFIKALMCPSVDINRHNNDGRSIADYLQELMYPKDGGPGQTTFLTRRIQLVETQEGVKSLRFLPRPRKRIRPTNVMASNVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXK0</accession>
    <name>A0AAE0NXK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_463690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="53948" checksum="4A9CE59E10E90DC4" modified="2024-05-29" version="1">MLARSASGPGGLSINTGTTGGLFGSSTNQAPAAGGLFGGGTSQPTQQPGSLFGTATSQATGSSLFGNTTAAQPQQGGGLFGGQQQQQQPQQPQQTGSLFGQPQQQQQQQQAGGLFGQQPQQPQQQQTGGLFGQPQQQQQTGGLFGQQSQPQQQTGGLFGQQPQQQQQQGGLFGNSTQQPQQQSGGLFGQPQQQQPGGLFGQQPQQAANTGGMFGRPQGLSLFGGQQQQQQQQQQQQQQQPGAGFGLTSQGPGLTMGQSTNQQAQVVPGIRIDVSNIKPTTRFNDLQEDLQKQIAQIDDGIQLCIRRKEEVDAFLPAHGSHLAAIPTDVSFVTRKSEGADGALRGDLVAINQLRELVKVDADNARLSFKAIDNLRLPTQYHQAGLWSTRGQQTAHGGTGSDADAESNSDLISYFSKTSDEMDEMMKKFEKNLSEIEVHLHGVQGNMLQQLQRMAAQNKSGAQSGMDEKVSELGAVLRDFEESIFQVAGVVGGVKEGITGLQLQDFMGHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYB6</accession>
    <name>A0AAE0NYB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferric reductase like transmembrane component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_464659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYB6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="257"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="559" mass="62338" checksum="284821D9C4B06D04" modified="2024-05-29" version="1">MSSIYTFRPIVKDQYTAARSYFLCVIGLLFVESMLRLPAFLLSLRKSDLGSAKHLQRHWTATVWLHKLSTLPSLVPFLTHHIIPSIFRCLVFTGLNFLWGWNRIRYSTDYQLYGWLTIANAGLALLFPTRTNLFSTVARIPSPILLMYHRWAGVAATAHASLHFGLTAQSYIRTKQFDVVLENIRIRVGIMAWAALALMFLTSIRLLRRRTFELFYYTHFIFLVFIGGALYHAAHGPEFLLPGLVLWAIDRIVRFWYNFRGITVKSVTQYSGNVTKIQFEGAKTVSPGQIAWVQIPSVSLANWHPFTIASAPGDEVGTIAVRALGGYTKKVQQSSIIPVSEPKCSTDRSPHSSSTTTAIPTRLRLDGPYGVGRIEWMQYPVIVLVAGGIGITPGISIASHVVKYAMARMAVETPPGPQWHIHLLWTVSDTSHARWFEDELINLAEPCARPNAPVSLDVTIHVTSHIVGAAAAMGRREGLEEENGVGDDASRRYNGPGEVRGGRPNVLKWFQRVKEARAGLDAAVNICGPRSLMDDARRAAAAVSCRGGLFYVEDEEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYH4</accession>
    <name>A0AAE0NYH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_519208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYH4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="3">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="414"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="4">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="104455" checksum="69EE05550710C288" modified="2024-05-29" version="1">MPLPPEESNNTRATPAKPSASPTISGARSQESDNGNKPKSSTLERFKSGPHARRIPETVWERWKPTIAEAYEVKGMTVVHLKDYMEREHGFVATKRQYVHRLNTLWKIGKYKKSSGPKRRRQAADLSAIEATSEQSHFEPEAYDEAYDEAYDDTSRTPTPRQFAHDLAHGRGQETVEGIPFGYSCPFRKRNPKRFNVKDYYSCAVQAFPDIGPLVSHILKDHRRPIQHRCVRCHRTFTGPHELEAHLRLPGNMMCAIEEGIQPDIATAISNTGFSLNVPTDDPEDGIRPEIAATISNMRARSRNVSNWPSLWFALFPSDTYARSYHFEPAVEYFALEDFIKTQIPGLGAWLAANYSELRFRGHTLEFDTKLLAYFNRLFESFRRSIKQSSAAMRLLNANTNTLEVFLGSDVPPYAILSHTWEEEEVIHDDLNDENVDHTAKRGWYKIRRACDQAIADGYTYIWADTLCIDKASSSELSEAINSMFKWYRDSAVCYAYLCDLPDVALEASRWFTRGWTLQEMIAPKEVKFFDKDWVFLGAKSDLVNQLHRIFQRRSHGPERRQPQTDQRGEKMSWASKRQTTRPEDIAYSLLGLFGISMPMLYGEGSRAFIRLQEEIVKEYDDETIFAWKSSSKIPITYAGLFARSPADFAQSAHIVPCQSTDVLTEPVTVSSRGLRIVAPLHTLDSKQFTESTFLLRLNCKPVHYDMRSRERIGIIVAKRFGIGHVYSRIYSDADLPIFNFKGEMQTIFGLKETHIEDLELADSCGFWVRTAPSWPSWGDYELVLGYPSQYWYARHDMFRRKWNDASTYLDYLRRPEFLLGTTTVVPSPSWSRYQMWCDIKFLHAVADLTAKDLEDLAQSDHLASASKSGNRDKHAIAEGGGLTLKCYVQLEVVYGQHLFVADLHVKFAGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYJ1</accession>
    <name>A0AAE0NYJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_464638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYJ1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="172" mass="18018" checksum="4154320CFC9B78FB" modified="2024-05-29" version="1">MSRFSSRTLSTLTSPLRAPSAFPSTISARIGTARPAAFVSLSRTYASSSPKSAEEASAQSGGSRGKDTTASEKDSSPTDGVVPDSLSEGGARGRTGGGKPLESSHSPPAQPKIHNQSVPGSHAKLTKEQQAEVDQHNKEFEEKHGKAQPASDDKVDKSFWSGQGDRQENPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYQ8</accession>
    <name>A0AAE0NYQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_428707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYQ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042231342" evidence="1">
        <location>
            <begin position="20"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="40"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="580" mass="63294" checksum="83D6E73EB1BFBFE7" modified="2024-05-29" version="1">MHFPILEVSLMALAVYAQASTPPSIALDWGIWQSQVDSLDSKIYVWNNVRFADEPPRFGKPSFPKGKNTSSTIDSCYQASPRSERFPAIQLPRDTVPQGEDCLGLDIYAPVDNFDDNGGVGEPLPVIVWIYGGGYTAGTKRPDPDMLYTGQSILRATGYKAIFVAGNYRLGAFGWLAGNYMETLTSQGEAQTNAGLYDQALMLQFVSQFISKVGGDPGKISVWGESAGASSIMHHLVREGGTVDPGFRSFFVQSPAFQWSWDNSPGGTMDKTFQSFSGKAKCGTVFNITCLKGRDVSDLVQANQDIVDDAWGNHMFPVGPSIDNGWIQNLPALTFSTAGSYWPTINSALISHTGNEAFLFTPITSIVTKQTIIDFLSKFFPGETLQSVRDQILGNYTKPCDSTYPGWKTCLNHIIRDSSFTCNTRWLHDAYPKANRWMMAYNFPNPVEAVHAFDLVPLYMNTFQDAFNLIRRNAPKLIPDSTVSSIASGVSNVVMQTYQAYAGSFGVSGDPNPVKLPAAAAWPTAQAGTAYGNVMGVSNANGWALGPDTKNTEGICQFWNGIATQVMAARGKQEEVKDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZI3</accession>
    <name>A0AAE0NZI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_466079</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="100"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="299"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="508"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3390583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="700" mass="75953" checksum="6F793AA4DB76140E" modified="2024-05-29" version="1">MLRSRQATRALRTLAELQPCRQRSLASSHKVATSIAARRNGPSLVRNQATSAAAKSPAADVRVSPSPAFNAALEPKDQSHVQPLVKGKKNDMDESFIGKTGGEIFHEMMLRHDVKHIFGYPGGAILPVFDAIYNSPHFDFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADALADGTPMVVFTGQVVTSAIGSDAFQEADVIGITRACTKWNVMVKNVAELPRRINEAFEIATSGRPGPVLVDLPKDITAGILRRAIPTESAIPTIPSAASRAVIEMTQKQLRASIGRVADLINMAKKPVIYAGQGVICSEGGPELLRELASKASVPVTTSLQGLGAFDELDEKSLHMLGMHGSAYANMAMQEADLIIALGARFDDRVTLNIPKFAPGAKAAAKEGRGGIVHFEIMPKNINKVIQATEAVEGDVGSNLKLLIPKVEAKSISDRQAWFEQIKAWKKKWPLSDYEHADGSGRIKPQTVIEELSNLTAHRKEETYITTGVGQHQMWTAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVAKPDSLVIDIDGDASFGMTLTELSTAAQFNIGVKIIVLNNEEQGMVTQWQNLFYEDRYSHTHQKNPDFMKLADAMGIQHKRVVNPDEVVNSLKWLIESDGPALLEVVTDKKVPVLPMVPAGSGLHEFITWDSAKDKKRREVMRERTCGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZP5</accession>
    <name>A0AAE0NZP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_410616</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="257"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1264"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3390673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146697" checksum="089BE17B6FC269B3" modified="2024-05-29" version="1">MAPFVDNPQIKSAELLRPLPLHRHAYIWPFAVIWPIFLRFYLSADLYAKHIAAPEWTFVWVGTIVTFQTLVWLCTHWSVDLNAIFTAKKATTVEDADLIKVVPIANAGAAEICKIVRDKNNVSFFFQKRRFLYSTEDKTFRTLTYDIDVTPPVKLDKFQRSKGITSAAELQRLEQHYGTNTFDIPVPTFTELFKEHAVAPFFVFQIFCVGLWLLDEYWYYSLFTLFMLVMFESTVVWQRQRTLNEFRSMSIKPYDLYVYRLGKWTETQSDKLLPGDLVSVSRTKEDGGVACDMLLVEGAAIVNEAMLSGESTPLLKDSIQLRPSDAPLDAEGLDKNSFLWGGTKVLQITHGNTEEERPKLVSGVPAPPDNGAMAIVTKTGFETSQGSLVRTMIYSTERVSANNVEALLFILFLLVFAIAASWYVWDEGVKKDRKRSKLLLDCILIVTSVVPPELPMELSLAVNTSLAALAKYAIFCTEPFRIPFAGRIDVACFDKTGTLTGEDLVVEGIAGLGLESSGTSTPRESDGAHSHMTAVHDAGIETTLVLATAHALVKLDEGDIVGDPMEKATLSALGWVLGKNDVLSSKPALATGKRTVGSVQVKRRFQFSSALKRQSSVASINAVDPTTGKKLKGTFVAVKGAPETIMKMLVSVPKDYEETFKYFTRRGSRVLALAYKHLTTENELGTKNINELKRETVEASLHFAGFLVLQCPLKEDAKEAVQMLSESSHRVVMITGDNPLTAVHVAKEVEIVDREVLILDAPEHTADGEEKLVWRSVDDKIRIDVDPTKPIDPEIIKTKDLCVTGYALAKFKDQVGWKTILRYTWVYARVSPKQKEDILLGLKDMGYYTLMAGDGTNDVGALKQAHIGIALLNGTPEDLTRIAEHARNTKMKELYQKQADLMTRWGQPAPPVPVMIAHLYPPGPSNPHYLKAMEREALKKGVTVAELAKANGTDIETITTPAAQQLINQDPRKAKQAEAAKKASGLADKLTQSMMEAEDDEPPSLKLGDASVAAPFTSKLRNVIAVPNIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLEGIKFGDGQITISGMLMSVCFLSISRAKSVEGLSKERPQPNIFNWYIIGSILGQFAVHCATLIYIARYCDVLEPRSEIDLEAEFKPSLLNSAVYLLQLIQQISTFAVNYQGRPFRESLSENKGMFYGILGVTGIAFACSTELIPELNQAMKLVPFVDEFKTTMTAVMVLDYGACWIIEVVFKALFSDLQARDIAERRPDQLERERVRKAEAQRIKDELLEAKEREKIADLERKMEERARQIRGWAQGTRQQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P053</accession>
    <name>A0AAE0P053_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_446908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P053"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="324" mass="35586" checksum="E9AD6D61A50C5861" modified="2024-05-29" version="1">MSRKICITAVDGQTGFLIAELILKDERFSKKIESVTGLALDPSSPKAKELETLGATIVPHNPGRERQMVNTLKKTGCDTICLVPPAHKDKFDICVELAVAAGKAGVQNVLLISSAGCDYAERDKQPRLREFIDIESVVLSAKGDPNIPLGHSPCVIRAGFYAENLLLYSPQAQEEGLFPLPIGENHKFAPVALGDVAHVAAHVLAGKGKHGFDDKHRGQMMIVTGPMLCAGKELAEAASKAIGTKMEFENISEREARRVLQSQTELDDSEKEYILEYYSLVREGMTNYIATTAFHDVTGEHPTEPDEFFRMYAGELRPKKKVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0C6</accession>
    <name>A0AAE0P0C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31471" checksum="7950E5163BC77AB8" modified="2024-05-29" version="1">MSGKRARDEGGAPTGGGGDDASKKKPKHGGFRVGPDNLPDGPWRRKTEKIKKNLIVKAKVKKQYAKVKAEFQQHQPAQPAIPYEEEPAAAPAQTEGAAPAAENEAAPAPATAPAPEPAPMHPSRLALIEDPNAPADDETNNHNEDTAADRKRAKRRGGKKLTGANADIAAEEDDPTAAAEKKEKVMQDPEHDAARRERQRERTRQKRPGYFDKDLEAAERKKREAEERAEEFARREAEKARRIAERERYRRAMAKAKEPGKDGKRKLGRESRILLDRVQRIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0R3</accession>
    <name>A0AAE0P0R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_126520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0R3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="158" mass="18079" checksum="0D06D8DDCC295DBC" modified="2024-05-29" version="1">MARDNAADDDRGGRTTRGVGDRRHIRHHSHRHHHQHRPSSVDSAYTASSSSITSSSSPSTTARSSRRKTRTTAVVVRGPDSDHPYALQPLPRRGHPPSAYDDDIDEYTVDWDGNHDQREWERQQQRQEYKRRRRHDKEGLSGLLIALGIMFAALMCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3E0</accession>
    <name>A0AAE0P3E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_51</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3E0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042245861" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3392684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="223" mass="23932" checksum="AF5F11618A18A06D" modified="2024-05-29" version="1">MRSAFVTTLALFGAVKAAVQGFDVSHWQSSVNFAAAYSSGARFVIIKATESNNYIDPKFSTYYTAATNAGFIRGGYHFAHPGETTGAVQANYFIAHGGGWSGDGITLPGMLDLESSSSSQCWGLSTTAMVAWIKAFSDRYHTVTGRYPMLYTNPSWWIACTGNSNAFVNTNPLVLARYASAPGTIPGGWPYQTIWQNSDSYTYGGDSDIFNGAMANLVKLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4E3</accession>
    <name>A0AAE0P4E3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4E3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084727" evidence="1">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="169"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="382" mass="39748" checksum="A830DC39BE879236" modified="2024-05-29" version="1">MYLSRLFLPLVFTVHVSSEALGSVLTASSASLSTLSSLLAGVPDVVQLLSTARNITILAPSNNAFTKLLARNPRAAELMQNPRLLTGVLQYHVLAGRVPASEFSTTPKFMPTMLTAPFANVTGGQRVELARVNETSMIFSGYKQSAMVTTADVEFDGGLIHIIDTVLTVPATPGSTAVNTGLTSLAGALQRVQLLDGLNLLTDATIFAPSNDAFEAIGSALNTLSLNDLSSILGYHVLATPGQVRFSTDLLVLDNPRNLTSIQGQNITIRRENGQLFVNSARVLIADILTTNGVVHVIDNVLNPLNASATPIPSATTQAPAFSGVSSVIDSPFTSGIVPTATFIPATVPLSNSAPGAGAPLASKAPYMAIMVAAVMALVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6E2</accession>
    <name>A0AAE0P6E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_39856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6E2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="139" mass="14970" checksum="928E8102386A9211" modified="2024-05-29" version="1">MMATLASLTNALGLASPARLAGSGEGWRESRLINMLPRCTVASTTVQASKLPIYRSGGSPWTDGWLRSCTDWPSRTSMQCASPPCPRIFSIRLATLPSSSVRPGSPSQLILVYQIRAVSFLITSIPPLSSWTRLPVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6H8</accession>
    <name>A0AAE0P6H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_41723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6H8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="654" mass="71161" checksum="0D234F221C1A54A5" modified="2024-05-29" version="1">MAGPDPRRSSRARTTHPQSQISSSTSSISGRTDRNPRQFNKGGSPHKSTSTGSLSSEPPEETITAEDNTFGTRRRTRGQGEDRERTGAKPEIVRMANGEEDIQEEDEAVRCICGFDEYPGPPPIDEDVKQGLGDSVDLDPIFPTDLTDDAAGFFVQCDVCKVWQHGLCVGIMTEESSPDEYFCEDCRKDLHKIYTASNGQRFSHYLPLKRQSRTSSRAASFNKDGTRSPPKEREGRNGRTSSASQTSKRRSTMNSREAAYDEAEALRRAIEASKEDAAPESIDGAPRRPKRGRSDSEEKHESAKRQRTSSRSVSPSLDKALDDSDNEGALTRNGTSKSKSRSGAVVRSQRSERAEKPSERDERERLRAEAANKRKGRAERRRLDDSDPSEELPLAARVVLKSGAVPGVPNATTSAAIDTTHPASTAEPPQPATQQPAPDTPPTSVVPIAASSTTTTTTTTTTTTTTATAAVAAAVITKADKKRSHRKKGRNQYTRDRDGHDDDSPARSQSRDIQKDDHAPPVTGKTAGEGNTSSHSRSHAKGKGGMTSKITMTDMKRRAAALLDFISRTQLELATETESRIAANAVPGLAAASERQTTADPGDVPPPHPPPQHDNSSATAVDSRLEGEFKDLNCMEMMDSLTRRLVKWQQEFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7Q8</accession>
    <name>A0AAE0P7Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Sulfite reductase [NADPH] flavoprotein component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B0H63DRAFT_492018</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="630"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK3394918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1492" mass="163013" checksum="82DA651D7EE8F598" modified="2024-05-29" version="1">MRAPLASISGPIYVTTQLLVQQTAYKLSDKIFSFSPETFDLDLAVKDWASAGEKNIHGETTTVVPLQTRVGAGAFALGYIFSKDFDLSKRHIPQTLLAPSLSLRHLRSSLDQLALLYGVASPFVAHIAAADYSANDGLVTEYESALQTAEDLGLSLVSSSSAYEVQHMSLFATLLAALLPTIHIYDGLRTARETLRVVDALGDDSIAELYKRISQEVGALNKRLDTAGKVVELLRSFNNKLGTAYSPFEYNGHESPDTVLVVFGSVESQLAKQVVNTLAAEGKKVGSLNVRIYRPFIEEAFLEALPESVRQIAVLGQVRDIASVEDASVRSALYSDVLTAVSFADRWSQEPSVVDVKYAASAAHTPSSIASIIYGLTAKGGQSDITFTLNSLDQVQQYIFWDLDNSTAVDSPSVLGNLFARESTNNVYVHEAYDNLLHGGIVRTDIRSSKKSIEVPFAVEEADIVFVGEEKLLKDIAILEGAKFGGKVILRLPNFKVEDLEKRIPAPARKEIQDKALELFALDSSYSPALEKEGQLLVELAFLKDRATLAEIADVLQACLHKVEVPATWAEDAAEVTFLVQSVVRNSFVPFQKEEPEPALKLNDWQSAAKALAFKEAFGTQDDLRPDLPVKTYTIHVKENRRLTPTNYDRNIFHIEFDLGDSGLTYNIGEALGIHADNDPKQVLEFIQSYGLNADDLVQVPSREDADVLDTRTVYQSLVQSIDILGKPPKRFFESLAEFATDEKEKARLEFLGGKEGAEEFKRLTEVETVTYVDILEEFQSAHLNFHDLVRIVSPLKRREYSIASAQAVTPTSVALMIVVVDWVDNKGRTRYGQATRYLSGLAPGSAVTASVKASVMKLPVKDTAPLIMAGLGTGLAPFRAFVQYRALQKAQGKEIGAILLYMGSRHKREEYLYGEEWEAYVDAGVITLLGAAFSRDQAQKIYIQDRMRQSMQDLVKAYVQDEGSFYLCGPTWPVPDVTAVLEEAIAEEAKANGRKVVPGKEIERLKEDGRYILEVEGYRAGKRTPPSIAAPNCLSRAVSKFADRTSRRGYATPGQDPANLKEYAFEVAASSVRFGPGATQEVGMDLTNMNAKRVCVVTDETVDKLDAMRQVREALVREGLDFRVFNKTKVEPKDYSIKEAIAWAKPYNPDVFLAVGGGSVIDTAKLMNLYSCYPEADFMDFVNAPLGKGLPITRRLRPLIAIPTTAGTGSETTGTAIFDLTSHHAKTGIAHRNLKPTLGICDPLNTRTMPAAVKASSGLDVLCHALESWTAIPFNERTPRPTNPILRPAYQGANPISDIFSLSALRATVKYLPRSVKNPDDMEAQSEMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPSSYQHAGYQVSSPIIPHGVSVAVTAPAVFRFTGASNPDRHLAAAEAFGVDISNVKRESAGEVLADALARFLADLGDQPAGLKALGFTGAHVDALVEGTIPQARVLMLAPGLAKELEGEREQLRRLFEDAMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P805</accession>
    <name>A0AAE0P805_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_506628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P805"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="407" mass="45314" checksum="926241C4BE50ED8E" modified="2024-05-29" version="1">MAWASKPIQPESRLFGEECIQWMNNQVRDCCDNHTHDLLDNNFIPKRLLDLSNSPPKLVLDAKLDSAGKAHNGDSPPLSCRNAIRTTKALDIRYLWMNSLCILQDSVPDWEQHCLVMDKIYRNAHITLCAASLSSCHESFLTPKGPRINSSAPILGLWPVETRRMSYSVILNTANLPAARGARTLPQAANRFNDPTTPAYSNTSLKTTRPSFAGLARLFHSYLEDKYICGHWDGDFAENLVLDLMTRLESRKGLLPSWSRLMQPGGTESLDNQPYISDGNVHPEYEQILFDAGANSFDELRHTGGLRLTTTVLEACHLGMSAKETTPTTDDANDGYCTFKWVSDFGEGVLAGNIFRTPDFILHPNDDKGTLAFASAIPDVANFKWVLLGSCELAGHSPPDDYRSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8V6</accession>
    <name>A0AAE0P8V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_518258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="432" mass="47643" checksum="D3CE0624790241E5" modified="2024-05-29" version="1">MVRHFRAQVKLLENYHADPLPEGFTPRRTTIVWAGASVFDGVRPRRPIFEMQEGGPEGITFLAKSRTDWGPGEWKGLFPMDEPESDVGEKNQQAPLMGRTYRQAYAVQVWLGLTPDDGYDFYDAVDVVEELCYLASHYAEKLSLPLSDLGKDLSASPDSDRWRIARLDLAGHWRASWLYAGNDGPADWSDIICAVLFAETSKIFSTAVEGLRGSDIFAINRVVGLARTTALVRADIKREGIDLHLLLVTNKPTLATDPRDTVYSLLGMANNKPPDGSDLFITPDYGLDTAAVYQQVLRNLGLPSWVIDWSKPSAGILLRETEADRLVGAANSGGYDACLGDTFPKVYTVDGTTLKLSGFVVDEISECLGDLFRRNVFRGMLNTFRWSSHLKNSPIGRTRIGLSAGLALIDKLYATLLGTKNGDDGDGTRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVK2</accession>
    <name>A0AAE0TVK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_545370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVK2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="412" mass="46303" checksum="E6CF3F9443EDC2CC" modified="2024-05-29" version="1">MDNPSPGDPAASAIVADVTALPPKMIELTMEGNVVLAISNHNETETREFLVSSKILALASKYFANLFSLKFAEGRRLAFGGEQARIELMEDYLDAMEFLLSILHSKTTDTIVSENPSYEMIASIAVQTDKYLCSDAIKPWIACWMLAHDLRNGISALWPDDRMYMLFAAYLFRPNNLGQVTTEISKQLKKPDVRVKRLEGGCRRLMKFSKIYHAEDGKHALTMSAAVTILDFMDSSHIAIVHRLQRGLAKLRRSREVHSLPRAQLKCLKCGKLYPPGSDDYSVFGICPCSRDLQRDGVCGPAYRVDHYFDELKKISMSPLWVVGAERTLEQMTTDVLKLVVPEREHECTGKEACCFKTELEHIPFDVQDIISKCVITQEDCLSDPGPALKHNGRIVFQTPAPQLDIYQGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZF9</accession>
    <name>A0AAE0TZF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_543370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="401" mass="43205" checksum="8A9DF89B03FA8A45" modified="2024-05-29" version="1">MSSKSPSKTLVILGAGIAGVPIAHHVLRFTVPKVPNLRVILVSPNTDFYWSLASPRGIISEDFSEKLFLPLATAFSKYDPKNFELIHGTAETLDQDRNTVSVALASGGGGIRDIPYDAVVVATGSRDTQGMPWKGLGSTKDTRQALHDLQHKINTAKTIVVAGAGPTGVEVAGELGERFSSSSTNTEVIYVISDDLPLAPPAKHSVRETVRSALENKLKVTIIKNTRVSSATTSTEPGKTTLELTSKDGRKRTLVADVYLPAFGVTPNTGFVPPHLLAPSGQIKQTARGLRAEGCENVFVIGDAGNLEDTRSFNTDRQTHYLARVLQTYFIHGGEVEEPEYKPGTDFVLGLSIGKNMGAGQAMGMKIFGWVLWYFKSRYMGTDVVGDFVEGKRSITGKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZQ4</accession>
    <name>A0AAE0TZQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_183755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZQ4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041918183" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="391" mass="43057" checksum="3EA4C5451EDA2AF5" modified="2024-05-29" version="1">MLFKSSACLTAALSVVSAFSIPSFEDFAIDSGLALSGLNSVALLKSYANFQGTCNPLNLKIRQEWRTLSKSKRREYIAAVKCVQAKPSNFGGSIPGAKSEFDDFVWIHLAQTMNIHLTGTFLTWHRYYIHVYEQKLQACGYNGNLPYWEWGLDVNSLKDSPVFDGSDTSMGSDGDYIVHEGLQLTLPGETAPLILPPGTGGGCVTKGPFKDMKLHLGPVIMPVYGSPNTTGALDPSADNERCLKRDLNSYILKTYSSFRNTTKLITETTTMETFQGVLQGDGRYTDTVSLGVHGGGHFSMGGDPGGDAFISPNDPAFYLHHAQVDRLFWMWQMQDYNNRKNVAGNNFFFDLAPSAAVTVEDYINIAPLTSTQYKIKDLMNTVGGPFCYVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U087</accession>
    <name>A0AAE0U087_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_433897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U087"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084119" evidence="7">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="48"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="257" mass="27482" checksum="FDFC8691ED3F3251" modified="2024-05-29" version="1">MLAETILAGALLLADSVAVVAFPILSPLEIVKRAVSPGVVIQKCTNPGMLALAYDDGPYTYTSQLVDILDKGGAKATFFWTGTLYGCIYKQAAAVQKAFASGHQVASHSWTHGHMGGMSAANIKTEMTKVETALVNLVGVKPLYMRPPYLETSGQFLPTMKSMNYKVITNDIDSGDWNNQTPQQSQAKFTSAGAKGNGHIPLMHEVYPGTVNTLTPWLINWAKTNGLKLVTVAECLGDPDGMYQAGNFTAATGPYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0T8</accession>
    <name>A0AAE0U0T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_447702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0T8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3386798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="622" mass="66964" checksum="3852093141A8AF83" modified="2024-05-29" version="1">MKLGTALSSTWAMAQTVSVLASQEGYPPRPSPDAVCRAAPGSADWPSQRQWARLNETLDGRLVAPVPPGAVCHAGWPTYSPDQCPAVQAAWLRYTFHDASLVSTYQSQFSNDTCLPDPKYPCSAAGYPDYVINATSAQHVKIGLEFGQPQDMTILRRLSELARKNHVRLVVRGSGCDFIGRSNAPNSLSISTRNIKGIVFNPTSFRPRGCRLGIVGPSITAGGGSQMAELYLATDKHGQTIVGAGGDTVGLGGYITGGGHGLLAPRYGLAADNVLEMEVVTPHGDIVVANECQNQDLFWAMRGGGGSTFGVMTSVTMRTFPTPPIVYMTAAIITNASDDSIFDAATYVVSQFPYLEAQGVSGYSFLQTDTADPFDPSGSGPRVNLYLLAMALQDTQEAAAVDAVWNPVFAHVNATWPRMSVVKMVRAYPSFAAWYAANNDTNPTGADHWSGSRLVDAATLQGNAAGGLPALRDALRAMAQGSGYVLPFLLSGKGVWNATPRGGGDSAVPAWRKALAHITTGLDFEPLNTTARAISTAMMDKKLGPIRALTPHMGAYMNEVYNFEPDFQRQFWGDNYPRLLRIKRELDPDDVLWCTPCVGNERWQEAEGRLCRVWVRSGTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U113</accession>
    <name>A0AAE0U113_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial DNA replication protein YHM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_143485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U113"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="34383" checksum="4E23FEBEEE8E396F" modified="2024-05-29" version="1">MSAIIAPVSAAVPPPPPATLEKKPVKFSNLLLGAGLNMFEVTTLGQPLEVIKTTMAANRGDGFTTALGRIWNRGGVFGFYQGLIPWAWIEASTKGAVLLFVASEAEYYARSFGANDFGAGIMGGVTGGVAQAYATMGFCTCMKTVEITKHKVASTGQKVPGTWATFMGIYRREGIKGINKGVNAVAIRQMTNWGSRFGLSRLAEQGIRNFTGKGEHDKLSPLEKITASALGGGLSAWNQPIEVIRVEMQSKKDDPNRPKKMTVGNTFKYIYSTNGIKGLYRGVTPRIGLGVWQTVCMVAMGDMAKTYVEKLTGDKVTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U392</accession>
    <name>A0AAE0U392_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_390632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U392"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="342" mass="37443" checksum="1A185E6BFCC87782" modified="2024-05-29" version="1">MDVLLSLPIASYFFTTSLTSWSTSLNLLFFYMTWSTLVLSHSPLKIELLGTAALHTVFWLIPSLLFLAFDTLLPSLAESIKFGGASALPPRSAGSIARLLSVSLFNLALELGVEAGASLGLTTFLQKPIFRTSTTLPLPWQMIKHVALLLAAREVLTFYIHRHLLHDKPVGGRIAAQHKQCGAHARRAAPFSLLLMADNPIPFLLHRFVPLYLPAVAISLYGGNLHILTYLLFVGLCTLEETLSMSGYSIVPGIIMGGIARRTALHYAQPAGNFGCWGILDWVHGTSLGKDVMEDIHDEAEKHNVKGRSAKAADDAGSMVQNGMNGLRRSARSRARRSKDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3F6</accession>
    <name>A0AAE0U3F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_518807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3F6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="14596" checksum="3FA031DF35FF8CC2" modified="2024-05-29" version="1">MVNEFVHAQKPTSEKLIIDTHGILVKGNTSTAGAGSLDTSKDFGGKYRSDDVSIGVQRCPKPSEIAVAMTSMVKNLDIELDAAEKTGVLDLSSLAAKCCDRFFNIHPFRDGNGRLCRLILNVILIKYAGVVVNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3G0</accession>
    <name>A0AAE0U3G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_463105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3G0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="224" mass="25824" checksum="B67E771C354D28D5" modified="2024-05-29" version="1">MDEMIAGLVGLKALYAEFVLGDRPWICDDSRVFKNPANSQKFLFDFASLTEPLEILHLTSVPGENWAVDVPVLHGWVWDRMAELKHLVIELPWLYGRQAELSTDFVIGDLHSSLVSLHLIDFWGVDDDDMPYYPRFVVEKDGSLKFLAEVLRDRIASSRPALKAVRITSPSFVDLPSHRRYEEAMEFVKYFKGKFAETGVEFSVSNTREFHGQWHWSGVDWRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3P0</accession>
    <name>A0AAE0U3P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_445605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3P0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="39477" checksum="F8295C152E71EFC5" modified="2024-05-29" version="1">MIIPRFRYQRAFSHLTETTIITIKEEMASQKNTEHPRPKISFRLPSLVQWLREAVPNVFDASGAGVGRGGEQGFFVVGEEQKQQQQPQGVAVGSDASPAISPASRAFAGEIIVNRGRDAATRILVVAESKPDVGVDDREGSCLLVTAAWRETETWSTAARRAAMPSFIRSRSLPPPPPTTTPSPSTSTPSRTATGCGAGLTPAKCTQYRQHAELCGIAQALLIADDLMDQHRIVQLVLVKVFADDVGAIDRLELGVVHAVEAPPSSWHNGHALPAVQAIISLFRHLARLGARVELDWAGRYVREEDVDYSQQNVPWTDRGSVLDRLHPQVKYQVSRKGSEGVPESVFAHGLTTVQKLVFTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U422</accession>
    <name>A0AAE0U422_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_390719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U422"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042096743" evidence="8">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="500" mass="55978" checksum="0B4885D19D33741D" modified="2024-05-29" version="1">MVIEAVLLLLCAGAVYCARAWIRLRHVPGPPLAGWSPLWMIRKLLGGRANEELHRVSELYGPLVRIGPNDLLCTDPDTLRRIAGARSLYTKGAFYESGRIIPGYDNVVSQRDEAKHKTLRAKMMAAYNGRENGNTTDTSFESGVDRQLLQLIALIDTKYISDHGTLRPFDLSAKSQFFSLDVISDMSFGSPFGFLTEDRDLYQFLEINDGAVPIMNVFQAMPWLTNAVQRWPLRLALPNDGDNIGLGRLMGLSKSYVEERLRPGSKAGQDMLQGFINGGMSYDELVQHMFVQIVAGSITTATAIRHTLLAVISTPTAYATLQREIDSRMMMGLISSPIITDAEALQFPYLQAVVREGLRMWPPTTGLGSKTVPRGGDVLCGFHVPEGTQISHNFAGLMRLKDVWGEDADVFRPERWLPVPGKDGEHERLRIMGQVLDLDFGSGKYQCLGKRIALMELNKIFVELMRRYDFAIINPQNPIKSWSGIFWIAGDLWLRVTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4G1</accession>
    <name>A0AAE0U4G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4G1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6606" evidence="1">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="211" mass="24070" checksum="7725458163614752" modified="2024-05-29" version="1">MALWQGDKTWQNLFIVTSCDGGDDDDDNDFLVEPARIPLATFSDPSFTETLATFLEQASTEALDRFAARSRKAGASIPEARDSVNPALISQMFLPLLEAIGSSVQVPMLRKRIRDNVNLDKAELPWRRLPYWLVLRVAVQRHLYLALGNNKGRAYYKFLIYALLSQLLTDCAGELAPKMTILLRSKLCRRLAKLEMERAEEPLWFFSYQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4Z3</accession>
    <name>A0AAE0U4Z3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_539265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4Z3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070925" evidence="4">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="20462" checksum="4597BCF66B1E4311" modified="2024-05-29" version="1">MKRRPLSLQGDVALWQLVSWLSWAKGAGCHQLLGLYMVTSGHSGRFGHEFLEFDFRVVGDGRSATARYANNSNYRNDSLIRKEMYISSLVVEEIKRIIKSSEILKEDDGKWPTKNKDGKQELEIRLGNDHISFETAKIGSINDVTESADPDGLRVFYYLVQDLKALVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6R7</accession>
    <name>A0AAE0U6R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_424422</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042033786" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3392680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="318" mass="32276" checksum="519F19E72DCDD7E4" modified="2024-05-29" version="1">MKAISILSLAAAVSAHTIFQKVSVNGVDQGQLKGVRAPYSNNPIQNVNSADFACNANLQIKDSNVITIPAGAKVGAWWGHEIGGASGPNDADNPIAASHKGPIIVYLAKVDNAATTGTTGLKWFKVAENGLSGNTWAVDTMIANQGWHYFTMPSCIAPGQYLMRVELIALHSASIQGEAQFYMECAQIQVTGSGSTAGSNTVSFPGAYAANNPGILVSIYDNAGNTNMGGKPYVIPGPAVLTCGASGSTPTTLATVTTPPATTAKTTTAAAATTTAASGGSGTAALYAQCGGQGWTGATACASGTCKVSNQYYSQCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U718</accession>
    <name>A0AAE0U718_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_456652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U718"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3392814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="21079" checksum="6ABA05FFE049C74F" modified="2024-05-29" version="1">MGKRKKSTAAAIATSAENNNSGNNNNNKRAAASCVIPNLLYLGPVEATSNAAFLTTEKITHVLSIGRNPTSYIDGIVYERLSLTDREDSNISFVADRACEAIDAAVAAKQGTGRVLIHCVAGISRSPAMVAAYLMKRRGMTLRESLEVLVRARDTVAPNPGFMRQLCEMEKEIFEGESTFDPVVVTANTRLASWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U727</accession>
    <name>A0AAE0U727_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_15207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U727"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="477" mass="54031" checksum="C661B8237059A445" modified="2024-05-29" version="1">MASLAENDFYLDKYEEKKLVSQPIFEYQFEHSAPWTSFTWNECDSVTRTERAEIIQSTKEMLQSMEADSFDLRILIGPMDHHDPIPPNDMREIVGKFGMPSCFVAERLANVTYSFGTQEDCNDHKQAAWLHLLGVIPKDPGVKKNEFGRGKGDGVPTAVYLQWTQDEKQPEEAARVTMLCFNPPRRFLRRIRALHANKTSAAWKETLQDPYMLLYLYYEAWCAALVDGCVFITTQARNMERSIFDEAQKVYDLNIEEINGTNMHEAHQIAKSTIFLLESLNAAVRSLNLAISRYAGTPATSERRVLVTGPCASSTRELLEYQRDVIESFRLRMESTEKRLQNAINLAFNIQAQKTSQIMRQDSRTVRVLSVMAMLFLPLGTVASVFSTGFFAQPDDGELVVLPKFWMLWAIAIPLTVSVLMGWVLWERRPRLVVPGSIMGVASVLACLSPQESDGEKARIPLWGAGTPEPQLGKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U817</accession>
    <name>A0AAE0U817_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_32249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U817"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="113" mass="12373" checksum="F73C84EC247E9C1B" modified="2024-05-29" version="1">MAGLLTSVNRLGGDCDPTTARCCGQNNYFPVYINPELQGCYSPVIPGYKNTSTQTTFDFNDIDASYLGPPKALAQRVYSSPLASTPCPHSITWYLSLVRLGRITSMAAIRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U835</accession>
    <name>A0AAE0U835_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_517431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U835"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="596" mass="65156" checksum="56FE22A2E0A9286E" modified="2024-05-29" version="1">MASRHADEDSSDASFGGFDEDDLMSLSEGEATNGSRDAMLLDEKDSDEEDLERFVLGGKASFREQLFRDDFGADSTSALVLASGQPGADTTGQEELDDAALFFIDTAPGEKPDLPTPAETPDTEAPAWEDSDDERLTVSLAGATRLRKLRDTEADDLVSGTEYARRLRQQYLRLYPEPAWAQEASASGKEAKRRRRSSAASQGDDSSASETSDGEEEDSALPLERFLRNANSFAGTTTNKRRKLRPETIDIQRTRDIPDAHKAAVSSLSFHPKHPILMSSCVSSIMYLHHVDPAAHPIPNPALTSVQVKSTDLRRAAFLGPNGDEIVFAGRRRYFHTWNLSSGEVRKVSQIQGHQREHRTMENFRLSPCARYMALASSDKKGGGMLNIINVNTMQWIAQARIDGRAGIADFAWWNSGNGLTIAGKDGQVTEWSMLTKRTVGIWRDEGSIGATVMALGGRSGGPVDLGGDRWVAIGSNNGIMNVYDRNELVAKSSKKAKGSAVEIKVQPTPARTFEQLTTAISVITFSPDGQLLAFGSLQKKDALRLAHLPSCTVYRNWPTEQTPLGRVTTVAFSAQSDVLAVGNDMGKIRMWEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U884</accession>
    <name>A0AAE0U884_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_517354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U884"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1135" mass="124656" checksum="2D0B0D811331A12F" modified="2024-05-29" version="1">MAGSSKPTEKKQVTLTSFFTPKTINGLSQRVQSSSARPASNSDGAATASPAHEPSRKRPLQENTDKGNETPDRAIKRAKPKAGDDKPKTPPRVAARPSPPSSPVAKASNPGGRTEKYVYDATHSSNLMAEDDIEDEDAAARREKDALHKKFVKKLGHPDSMAMMRRRNFQADAETTPVDGDDAEGGEDPDEEEPAPPSKTKKKGAKTGKLTPMETQFLEIKRKHMDTILIVEVGYKFRFFGEDARIAAKELSIMCIPGKFRYDEHPSEAHIDRFASASIPVHRLSVHAKRLVAAGHKVGVVRQIETAALKKAGDNRNAPFVRKLTNVYTKGTYIDENGELDQPGENTGAPSGGYLLCLTETPTKGAGTDEKVEVGIIAVQPATGDIIYDGFQDGFMRRDIETRLLHISPCEFLIVGELTKNTEKIIQHLSGSSTNVFGDRSRVERIPKSRTMAVEAASHVTQFYAGKLKDSDERSAGLLEKVLKLPESVTICLSAMITHLTEYGLEHIFDLTKYFQSFSTRQHMLINGTTLESLEVYRNATDHSEKGSLLWALDKTKTRFGQRQLRKWIGRPLLDQQEVERRVCAVEELLEGQSTMKVDKLAGMLNSIKADLERSLIRIYYGKCTRPELLSTLKTLQKIAMEFARVKSPADTGFKSPLISESIYALPAIGDIVTSYLDKINPEAARKDDKYTFFRDEEETEDITDHKLGIAAVEQDLDDHLKDAAAKLSKKSPITYVTVAGIEYLIEVSNTDLKRVPASWAKISGTKKVSRFHTPQVMRWINERDQHKEALAAACDAAFTALLESIAANYQPLRDAVASLATLDCLLSFAQVAALPGYSKPTFLPITAPPTISITEGRHPVAEHTLPNGYIPFTTSLASPAPLAHLITGPNMGGKSSYVRAVALLVLLAQVGSFVPATAMTLTLSDAIHTRMGAQDNLFAGESTFMVEVSETAAILRSATPRSLVVLDELGRGTSTHDGAAIAHAVLEHMACETQCLTLFITHYQSLARVAEGLGDGRVKNVHMRFTAHRRSDKAIDAHAHGDDAAIGEEDADEDEEITFLYEVAEGVAHRSYGLNVARLARIPRKVLAVAALKSREMEDEMKARRLRGAARLLEDVLHHGPDQLDHLISSMEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8A5</accession>
    <name>A0AAE0U8A5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_517630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8A5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="722" mass="83499" checksum="BAAE487CE7AC63BB" modified="2024-05-29" version="1">MAAPASDAKDGKAFYGYLFDKHKPIPNPTPVLDSLLRALAIHIRNEIGDKADKKLTPTKLAAFYKDAGHNYESLFVEMPAQSISFIYQVQGCQHTLQPTANDFDPPSIPALTVRGFVRWQAIQTLLEPQTHVPVLQFAVRNWALKNPVDGSPFPPDLPTEAFPLETDPDTDQWHRGCAHKLREEATPKEPSRAEFADRKVPFSHVRINPTSPRDYFARAPNVSYVHVPSSPYPGRGVGAGRSPERDRERERERERDRERERERDRDRERDREREHRLHRQGSSSADERRRRSFSEHAPHAGAPPEPVRPVRVPQVVPERAPTSRARRHSQPHHHSSSETDDTQISPGTKRVPSQPQRRSRDPPPISVRHVYTGAEDGPRGARASMPPPPHPHTRSRSPSAGPHPDRVVARADDHKRRSIFDYGKEKLSSLLDGGGSTERQRSGSRGKDAQLLNHHSSARSSREDNVAGSRLSRAWSGDEPDDEDPEVAARRRRLKRDRDRDMQRERDRDRDRERDRERDRDRDRDARDRDRDRTVVRDRERDRSFKEHRDRDRDRADRDSRGRDKSDGGARLSSDGSRLASGDRPLRVPHRDRDLPPQRPGDTDEDTPSPREFSRSGPYLPRPENHRRTSSHADIDRRREWDSPATAAARERLRDPPEARERDRERERERWRREDRDRDREPRVPRDRDRDRADRERDRMPSPVVTGVSGRKYPDVGWSRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8G4</accession>
    <name>A0AAE0U8G4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_54481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8G4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041922456" evidence="8">
        <location>
            <begin position="30"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="172" mass="18222" checksum="13F3F6316E121F68" modified="2024-05-29" version="1">MPSTSSSPPRWGNLLVWLLLSCLAGYATATETAAPTIYTATSGGFKYLGCYNETTGIAGTVGNRALYGGSNQVLPGEMTVQKCQDFCKKSDSNYKYAGLEYARECWCAISLSSLSEKFPDTACNLACEGDVTQVCGGNLKLTVYIARAASSIQITWAAVLVSLGAAITLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8K3</accession>
    <name>A0AAE0U8K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_46589</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8K3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3394464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="674" mass="74834" checksum="19E24AC148745B87" modified="2024-05-29" version="1">MAPSSRNPNNLGQIIEYIPDRLYLASYVEAPDENTLFPYPDPPAPRSPSKRSQRAVDGPAPAQPAALHKRPYYFTVDDTLLYNAFHHDFGPLHIGHLYRFALQFHEILGARENKERPVVFWSRADPRSRANASCLLACYMVLIQSWPPHLALAPVAQVDPPLMPFRDAGYSQADYGITVQDIVYGVWKAKEEGCCVLESFDLDEYERFERVEHGDFNWITPNFLAFASPQHTPVTRTIEGSEPWDALPKSLAQVDAHPTLPQSFKNVLKHFSERNIGLVVRLNSVLYNPSFFEALGIKHIDMIFDDGTCPPLSTVRRFIRLAHETITVKKKGIAVHCKAGLGRTGCLIGAYLIYRHGFTANEIISFMRFMRPGMVVGPQQHWLHLNQGVFREWWIEERIERKLRKEAAIAAAAALSSTNHQPSTPIRAMQKASLGRSASKNGGGTSTPPNRSSNRTPLGEMDSAHGRDNTIGVQEDYLPAPTPGQPRKTQRSAMDRHHPYTRGVHTTTTVEEEDIPVAEDEQTSQAEVISATHRTSQGTESDEEWHLRMRTTRRQMSTSPDRRERSVSHQTTTTTTTMVYQVNIDNDASNDVENLPSATTRTKSYDQVQRASSASGVLAKVRGTNSSKRAAGTAPVASGVVREAGVRKTSGRIGSISAAPTAAATTTARKISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8U5</accession>
    <name>A0AAE0U8U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_555934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="186"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="58873" checksum="C1C792E75ACE1D75" modified="2024-05-29" version="1">MGGVNKPGKPKSKRTPTRLRNKIEKASNSKQRKARKLAKKSPEWKSTLKKDPGIPNLYPYKEKLLNQIEEDRIRKKEEQLARRALARATTAGESAKDGIDEVMDADRVDAELSGDDADVMDADGSEAGDDESNPLAALIASARKAAEQYDKELQSGDDMDEDDEESDSDEELDYGVHEVPGGSSSRKAFDKVFKQVVDQADVILYVLDARDPEGTRSRDVERAVMKAAGGGKRLILVLNKVDLIPPPVLRSWLAHLRRFFPTLPLRASNPAPNAHTFNHRDITVQSTSATLFRSLKSFAASRGLKRSIAVGVIGYPNVGKSSVINALLSRLSGSRSQHNACPAGAEAGVTTSIRAVKIDSKLTLLDSPGIVFPSTNSVIPGFVPKNTTEAHAHLVLLNAVPPKQIDDPVPAVNLLLKRLSLSPDLMERMMKVYDLPPLLMNQGDATMDFLVQVARKRGRLGKGGVPNINAAAMTVITDWRDGRIQGWNEAPAAGVSITPGVNNEDATPDQKEIVTEWAKEFKLEGLWGDGGGDDTNDVEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZA9</accession>
    <name>A0AAE0JZA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_529819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JZA9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="175" mass="19064" checksum="753AB783E0F78A65" modified="2024-05-29" version="1">MLDSGAIVECISPDFCRRLGLTIRRLDVPSTINLASDEHNSIDSYWIVNILVAGAMTVAMAFVYGTGEAYHMMLSLNCMGTKALYVTSAQRSGIVDIRVGEEEDEATFSGYEEDSDQEYGTSFRALATATEFVDLLEASGMAPPSEQSTSSDCWYDTDDTEPTEPRVLAGNGDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1P5</accession>
    <name>A0AAE0K1P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_535949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1P5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042084722" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="50992" checksum="4DE91E3C96401E83" modified="2024-05-29" version="1">MASGRVSRWMLILLATSACPDLSAALAARGSIDRYSNLNAVTPTGTGTSPDKWHNLWTSHRPTDAPNQDLGAWQDLRREVGAATCGFFPEFGDPYDCGPSRICTNSGNYRRCCSGRECSQALPTACIGLRGGDCPEGGTICCQSPLYCATFLWQTSASPNKIFTILDCDQINYPEPISILAEPRNAAPPAAATTTPLPAAPNTAPALAAPTTRPTAPQAVDPPKQQTEPQAAAAPSPSNQNQAAPVDTTTPNSPTNPKTDTQPNESKPTTPSSSSSASSPSLVLLLSSTSESRQASSTSSDLPQVPTSSTPTLSSETLPVNSASSSSSTIVPARQSSGSSSESNDVSNNNTAGGSNNNSDRSSATDQNQSTPNNSNNGSSSTASAGAIAGGVVGGLAVIGFVVVALYWLRVRRVRAAATAGGGLPSYELAGDHPSSGSPARQWRSPSSSPSQLSSASPEMAKTGYAVEMPVVPLRAELGLDNNKSELPGSYGYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1P6</accession>
    <name>A0AAE0K1P6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_455240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1P6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15097" checksum="635E1AC9C4D5F6D6" modified="2024-05-29" version="1">MSRALNAIELALHDDTILQQSVDQWRERASSSPVVSLLHRDHELGRLFKIMERDLDPTRRRIDGAFQALMSSMRIVESERAIRRAETVSRLTHLAFFFIPLTLVASVFGMNVNEIADHLTGGFGLSLLSHAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K246</accession>
    <name>A0AAE0K246_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear distribution protein nude</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_80411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K246"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="131"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3368718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="615" mass="66492" checksum="327C0C2807358CE7" modified="2024-05-29" version="1">MAEPPSSPPSAEATTEDALAWYKSQYEYLEHELSEFQASSKELEAELEKDLDAADKRERSLQERAETLSFEVEEWKRKYKEAKTESNAAQGVLEKEVTTLRDSNRTLQLKLRDIEVANDDFERQARTTTSSLEDLESKYNVAIERAVMMEEEIKIGEQEREHLRVETQRLREELADLKIEAEILQDKIRKQESRHLSAISTDLSILESPTFDNSPNSTASSPMVTTPPDTKSMTTVDTVSEIQDPPSPPMSDASVPMPKAAPATKTPAPITQRKPRFPSADNSVTPKPKQFNTARPLGSRVATTANPLRTPAPRSTAKGLPPRATSHRIPPSTSLTHIRTLTAQMQRLEARVHSARSKLPAPVNTPPRASPRSSVAIPSTVTVRSRKRTVGSTTSSSIATDDATPTSHHSHIPDFRSSVSSSSTTNKHVPRLSTSGVSRLSFGPLPNRNPGGGSTMDSDMSRPSSRASVSSYARPASRTDSHAGESRIMPPPRPMSRTSLGGARTPLGRPRSSLGGSMHGHSQSVSYSTAEVDELLGADGELRTPSRRGTYSRLELDALAAGAGSGIPVPSGIPMPSSTRRQSGGTSVATANRRTSAGGGPGGTIKRLADVGETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K386</accession>
    <name>A0AAE0K386_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K386"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="384" mass="43781" checksum="4F9377E276C90830" modified="2024-05-29" version="1">MAAQLLAEKLRSTDLDETKVKYGIVFNAKDQAKDQAKDQAQTLLFVRALDSGSISQAQLVLDISEEEHRPLRVRKVLWRRLPASGHLSTNQERRKKGFETDFSKVEDFQTAAPGARFGIPELYSHEKLPCRSKTTLVSYWEFLNGGTLNRPEFMYTWLDDPTFHLDAHGDNIMLRFPRESSLFPEAHLIDFGKAKTVKTVMDWDVKTFVKPVVLRLAQASRIAPPYGTDWEQYLNKPAACGNDPFCTLWQNLEEINELHDWRRGVGVPSLKPVIDELGKSIEKELPVYIRGGGGRYLPFQNFLAEHRQTRDLDPNLGRPALYSSLDEVLKVKNVRGPWYVGVVDIKSKELVHTFDEAQHRPNEVNTDSKSDEDALEGEDSDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4N2</accession>
    <name>A0AAE0K4N2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GLEYA adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_497141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4N2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041954435" description="GLEYA adhesin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43245" checksum="3604F1F80A937BD3" modified="2024-05-29" version="1">MKHTLALLPGFAWLAAAACCRSNLCLREITGDDVPGKDGLGDCSSYLAVTVTPEVLTIYETATQAPVDYTTQIQSDILTVTETTVASTETRTVTVKTSSTATTEVNVVTAVETVIGATETLTSTITSTKLTNAGLKVRQAEAPFPEYATSACKSFNKYASACSCAGVLPTTVTLSTPSTTITVTETNAPVQSTVLTTASATETTTLSLTETITDITTEVDLLTATIASTTTATVSLTTTTAATATKLAGICLKGAALGAFKANATQYGTAPLNIYANLLNGLTGGITWSAASASTAASVQNKYIWSLDENARLNLAYNVPPYTYKYYAYMSTASPGSNWPQVNTEASVAAQVNNGGAVTYITGCVDSVTGELTLNAAGRTHILWCGQQLWMSYAKGEDINRGVCVEMFPRVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K589</accession>
    <name>A0AAE0K589_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_528036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K589"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF129">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="539" mass="57374" checksum="CD9B9363B68D5A31" modified="2024-05-29" version="1">MVVFMTDDEESMVTGKKKKRKELGHRTTAALPETADVVIVGSGITGAFAARFLKQRHAESGGGGGGGSVVVLEAREACAGATGRNGGHCQPLLYAATPAIAEFELETFRFLRDLVKEHDIPCDWVILSGGVHAFLSKDIFDLASKGVAQLEKHHPELAAQVKVVSPSSSSPSSGVKTKDATTLASLRVPDVPGAILQRNAASLWPYKLVAWVLEDLLRRFPNAEAFNLQTNTPVTAIQRQQRQRDGPGNSITYPWVLTTPRGRIAARQVLLATNGYTSRLLPAFADLIVPVRGQIGALLPSSSSSGSGVVPKLDHSYVFIKNGSASSWREDYLVQRPLSSDGGGGHLIFGGGRSRARNQGVGEWRDDEVEPPVAKFLRTNLSPRPLDLQPTTTPDDSSTSSESRTRSEGGGDLEASFEWTGVMGFSRDHHAWVGAVPESLGGGDGLYMCAGYSGHGMPAAALSARAVVEQMVIGSEGGGDQGQKSVVGDVRKIPDEFVLSEERVRRARDYLETIQEAEAKGLAGLFPELVAAAAGGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K596</accession>
    <name>A0AAE0K596_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_514498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K596"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="246" mass="27442" checksum="ECFFE06CDCC07104" modified="2024-05-29" version="1">MGLISFHLTTPRGCLRMWQLGLAAVDAWFKITNHSDQLEASSPRIDKVLALWVLSSSHKSRATNASAVVICAVLQPASATPLAGSPANKKGRPCRRPLTRRSHVSAKLPEQPNHAGVVREEETRLGRALDDAREELNVSRYHLAEAKANLEKAKGEFQMLDNKELELDGIMYILDNSTRELATLKEKVEPLVEFFQNIFGQIDHDVDVNLETFLRSIVNGIKEGKSADEVEALNISRRSKEVVRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5E8</accession>
    <name>A0AAE0K5E8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_373813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="30891" checksum="8562E322AF731070" modified="2024-05-29" version="1" fragment="single">PDGAMPLPVAPGPDESHAALMLVPVITLLVISTSLMATRIYSRLRPVVNLGWDDAAAVVAAIASALQIAFLFAAIPHGLGRHMFYVSPADGLLSAKLIFISQFPWGWAVSCAKISIALLLLRFKTTTSWRVFLYLMIALQVVLALIANIFQLVQCKPISAQWDPMTPGAECWDPRIAQKGVYVQGSLSVLSDVVLSLIPISFLKELQRPLREKLVLGFLMGLGVFTASAVVVKMTVVGNFGNTTDPLWDVVTLATWSIVEAQVGIIAMCVPTLKGPMESVLRRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5F0</accession>
    <name>A0AAE0K5F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_486938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="67481" checksum="42C80F29400C8E94" modified="2024-05-29" version="1">MASSSDAPIVWIDSLPPELLSDIFGYLAPEPSVTRFHGQPGADMFTSLGEQTLKNVSLVNKRWRATSMPLLFCHALWHLDRWEPIVTDKVERIPFLRFIRDNDLGRHVDTLTLVFPNATLQRDEGRLRLPEDSGSSLTRNGQPSPRRVHTRSSNCENWVGPRQYSERHLTFTDDNNRVWALLFTLMDPRTFTIVAAPQILAKMFSRGLYLGDAWSFNRGELHLISLSCETRSPPPPISQLELLDVWDPIPRGPFCQCNRSRPRPCDLFTIRPWTSALLNEGSFTRVYKTYEFFLRRPPSILEALLGYGDRPNAEPLIPDTVKSFSYVAVFPLSTHFNHLVTYLPHVEHLFIQLVPRDDIFSSANTEEMRNVQASDLWMERNSCYSLVMRELLSSAVMDQDDDDDDDDDDDIQIAVEQQTFEPFSHNPASVTPPPRKANWRLLKEFESGDAADREAWEMAVHYVNSSGSAWTVEREGVFVKMKGTPNGSGKSSGDNNDYDMVDGGDAQREPGQAGEETEETAAVQIFQGQLERLAFSGVAKLPYGPMMYAMDDSEAVYASMSSWQAAMQLEDDFELETYMQGVDAPTLWWQNPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K616</accession>
    <name>A0AAE0K616_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_487102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K616"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="530" mass="59207" checksum="46BDF46F36E90770" modified="2024-05-29" version="1">MISFYPNCTLPTEAQGFVAAANVRSTMDIVWTCLSTIVLSCWSALHLNVPPQFNPTTTAQRWRYKGFLLLRKVKFLLVMLIAPELLLSMAIDGWWFVHRHTPILQKLADEDGVPWSKSHTFFSNMGGFVVRFSAVSELPSVEQGQASTIELVEMGTDGTASLTTQHSSQWTTPSPERRSHSRFNSTIQRRRQRFKTRVNELSKKYGPAVWNVHGVNESIARDLFSEESSRLNPDENLSSKHSFIQMLLHLEGDAWVLTSAQLAEARRRKIIRRLPDITEQAIADKSKGELVVKLLALVQVVWLVAQMAARQHRSLSSSPLEVMTLAFAVCAFIIYILLLGHPQDVMTPIYIQADSQHVLSLGDMEAIAQLGPYRTELGTDLAVPHDYHSTSKLPQLSAISNLSILSILGSGAALFGGIHLIAWDFPFHTFNEQLLWKVSSFVTMLAPGNMILLILFAIPLEKVLKKGNTYVVFLVCGWAVWVLAVGALVLLALALLLARFFLICEAFISLYYLPPDAYYATWTASAPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8Z4</accession>
    <name>A0AAE0K8Z4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_563709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8Z4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3372261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="239" mass="26821" checksum="CD11A89CC2C909C3" modified="2024-05-29" version="1">MHQRAVHLPSGQCPPSSLAEPASEFGADTGEHACSLFQHTGVFVPARRSNCCRVRTGLRPMPFLQMPFSQMPFSRIASPGQHLRDLSRATLSKLEGPQQAPPVTLTTMNIMSGEEQKIEGNLGHLVTPSTNNIIFRPHWLSSYWADPGQTPPMQRRGRKMPLRPARTIKNKGNRCYNCHCTWSTEWRRGPDGLHTLCDACGLQWAKRARARLATAPKQKATVHMVKTWKTLKQKACYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K980</accession>
    <name>A0AAE0K980_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_527099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K980"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="583" mass="66699" checksum="D77BE9DE74836070" modified="2024-05-29" version="1">MKVKLEVTLEDMSLPLSPRHDLEILFKSFAAASWEDGVTLNHPTENESRQAWMDRCRGYFPLQELCTDDLCTARFMLRLIHDRAHHRPDEFWKMDQKAVYLGIAIRMIPRRFLPLHVPCVGVDTWCIERITSKSDLYSAYERGDCIPVSEALVALFRQAMITTFVNNLVQQLLKSYKLEKVPEDSKFVSAAACSQFIKRLEIIPEGLTKIECAMRALYALPSRTSIKELRERCSGELSPEEKKKKILARIVFRALEEDKYVEFMVDLSYFYKLMFTDLNDCALFASSPQAWHLFEPVSPLMSKGSRKLMKGLAITSSKNKIIKIFNDVFLNGAAIGYMGAENTLQSLGELIDKDREHDIFGFSSDFSKRESEHECRVINRLEKDSRRRQRLVVTTRMLERPAKILALPFPDTTYATTGKLASLWKLLREEPDSTGNVHPAEYKVYAPASASEDLVLPTRVVNPVLDTVKDGENARFTRAKAIRRALKDLGFLLSADKGTEKRDQLEWKAFVQAMFQLGFQVTTSGAGSKWRLRPREDCVFTIAHRAIMVDRPHGGRGDARPAVISRDIGRRIKKHYGLEYEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9F9</accession>
    <name>A0AAE0K9F9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_401354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9F9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="208"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="924" mass="97592" checksum="9DDAB07A97C92ACB" modified="2024-05-29" version="1">MAAAPAAAKPPSGPEGLNVIALISGGKDSFFSLLHCRANGHRVIALANLHPALGPPGYSSFAAVSGPALASDVATPAHHLDQSLPKAPRQAQTIRADPDTEPAEDPAPAGPGRSCGGAVGNDTPGLGGEGDDQEQEDDLNSFMYQTVGHQVIPLYAEATGIPLYRRAITGGAGQHGKDYSHYGDSSLSGSGTACEARAADDTEEADETESMVPLLRAIKAAHPEANAICAGAILSTYQRTRVESVATRLGLVPLAFLWKFPVLPATWSEEDPLAPTETQLLDDMAAVGLEARLVKVSSGGLDDSFLWTNVASPAGRDMVQRAMWRFGPAETGAVIGEGGEFETLVLDGPARLFRKRVVVDEADRQVIKEGGGSAWLKLRNARLEEKEKTTDPSDDDNDGEDKVRIPGLLEPRFISVQDALKTAEETAAFLGEGEQAVTLPRLGRLQIGTSEELQQLCFLGDASSRSASVEAETRSIVEQIRQGLRVAALLPSAIVSATILLRRMADFPAINSIYGELFDAPNPPSRVTIACGGLLSPGDVNIAVYLNVHSGLQPGQRQGLHVQSRSYWAPANIGPYSQAISVPVASLAAADANVATDGGLKFVSIAGQIPLIPATMALPAGDNTMRLQLALSLQHLWRIGLDTDVQWWTSAVAYFPSSGVQPDAMPLNARLAGKAWETAHRWSPFEDSLDEDDDEDNDGPDLWESKFNRGAMSLAAGGGYRDISDAPEGSLLPKWSVVDPATRAGKKTPPLFTAEVVELPRGAGVEWHAHLGIAKASDGSITSRTLLQDSLGAGSGRSLVDVHQTIIAQQTPGEAKEIAVVQTVVAERYAPPTSGNSKTGSGEGHGPVVLAALAQLGDVVQGCRPSLVVRYVDVEIYPLEFGATRMSGEDDGRLAPVVPCASLWDARGRRLASVGVYQSVFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAC7</accession>
    <name>A0AAE0KAC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_298495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAC7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8771" checksum="3515FC1AFFBB7642" modified="2024-05-29" version="1">MDDTGNSTTGFRSERSDSTSSASSMASPRRTSSHGLFEGLTAQKRKDDPASMTRRQSMNEQRPAVGFIGQMWNNWVRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE90</accession>
    <name>A0AAE0KE90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_253141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE90"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="120" mass="13754" checksum="FE8E9C192C343116" modified="2024-05-29" version="1">MARIPVETLPKTFQDTVNFTRRLGIRYIWIDAICIVQGDEKNWLHESAKMCDVYGHAHLTLASAHSPDSEGGLYSRVDPPVHIAVPIHGSEYNLLTRKTLSIYFCNHIGSTRFLRNWIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF22</accession>
    <name>A0AAE0KF22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H63DRAFT_419921</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF22"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3375321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="728" mass="80338" checksum="A975F66852299BD4" modified="2024-05-29" version="1">MADKEATVYVVDLGESMADCHNGRSESDLDWSMRYVWDKISTTVAANRKTWTVGVVGLNSDDTDNDQEREGLKGYDNISVTKNIGPVTMASLRELQAQIRPSGSAGGDAISAVVVALAMINEYTKKLKYNRRIILVTNGESAIDGDQIEEVAFQLNESNIELIVIGVDFDDADYGFKEEDKSSAKATNEKILGKLVNQCSNGVLGTMAQAVEELSIPRIKAVRPFKAYDGTLSLGDPAKYESAMSIHVERYFKTKRATAPSASNVVVRPDHGGGPSQSTQTLDEDVMMGGTEFSGVKQMRSYRVNDPDAPGGKKDVEFEELAKGYQYGRTVVPISESDFETTKLETKKSFTIIGFIPFTSYEPFLNLGEASVVVAQKHNEEAELGLSAFIHALHEVESYAVARYVQKDGAPPQILLLKPNPGLEDGFECLYDVPLPFAEDVRSYHFPPLDKVVTVTGNALTEHRLLPMDDLKQAMSDYVDAMDLSEFGADDEGNPAEYVQIDELYNPTIHRVNQAIRTRAVHPEESIAPPAEILLRFSHPPEKLVEKARADIESLVELADVKKVPEKAQGRRFKKNAVKPLSGLDIDALLGGPAGQSRRTTISPDNAIPEFRQMLQTAEDDTTTQSAFKQMANIIRDLIKTSFADVKYAQASENLGVLREEIEKLDMPEDYNKIIKALKRSILTGELDGDRRDMWTTHIVGRGLGLVTSEENPLSKVTEDEAEAFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF47</accession>
    <name>A0AAE0KF47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_438636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF47"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="256"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3375364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="45135" checksum="FCFDF11B55E54D17" modified="2024-05-29" version="1">MPPIPDLPVLAQEDSMLSHKFGRETANYFSGSPLNRLSFLRHDHDFLRSAFAHPSAAFLLMNNLSPLVQKADSTQLAFVPTSDVVSLTGPDPFAKTEADLIKDFNSQDTHPVVLFLGVDDKSQLPSHGGRSAGDEPFAYKAYKGAPYFAVDVTPTGSTADAARALLAAVEGRGFTLHDSSPRHMSLPAGQAATYGHARALLDWNARNPFCAQCGQRTLSVNAGTKRVCPPTDAASGAVTDRLPCATRGTVSNLSFPRTDPTVIMAVVSADGSRILLGRQRRWPQYWYSTLAGFQEPGESIEEAVRREVWEESGVSVGRVVLHSSQPWPFPASLMIGAVGQALPGDGETIFLGNDAELESAKWFPLDEVRDALLRGVSNLGESAPEGYVEGALRLPPQTAIANRLISSVVEGWWILPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFQ7</accession>
    <name>A0AAE0KFQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_496558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFQ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="340"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="687"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3375385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="765" mass="84592" checksum="F22C869038327028" modified="2024-05-29" version="1">MTSNNNSYYSAPQAQIQPAIGQRGPVRSKVGPGLETSNGSFKFPHFPDEKDASGVFANVNGFPASKRPSQDPSYLNMVGGATRDPSMPSSSHSETELRGGGSAYGDFPYGTHAQNAAHSQRPSVSGHSASFSAQNNRMYNHQQMDEEELPDRLRTLSMADGSNGIANGLPSLGYGPSQPFQFNPGSQPWENGQGFAPYSKEMYSSVVGHEKRGSIVDRGSPAGSAYRVGLGSPKTFPSTPQPGADPWSRPVSRDLRSSHDTERRTNAQQFVQQQPPQFYPQYYNHSYQPFPPHVYDSYSMNYNRPSTSVGGFGPPMHAYLAGAPNVPIRPSKDQDPGKGIRSVLLEEFRSSSKSNKRYELKDIYHYIVEFSGDQHGSRFIQQKLETANSDEKEQVFREIEPNAIQLMKDVFGNYVIQKFFEHGNQVQKKILASAMKGKVHDLSTQMYACRVVQKALEHILVEQQAQLVKELEPKILEVVKEQNGNHVVQKIIELVPRQHIGFIMDCFRGRVSELASHSYGCRVIQRVLEYGTEEDKAFIMAELHQCADMLITDQYGNYVTQHVIQHGKPEDRSKIIAIVTDQLVSHSKHKFASNVVEKCIEYGTTEERRIIRERLMADRDESNSALGLMMKDQYGNYVIQKLMSQLEGYDRETFVEEMKPQFIALKKSGTGRQIAALDRLMTTAQSSVSATKNATPSSTAPASPSLQVDVGSSVPTPNLTMETNSPSSSPPSPNAAAVDDAVERANIKLAGSDIAACAQPHVNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ57</accession>
    <name>A0AAE0KJ57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_221262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ57"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041981402" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="153" mass="16678" checksum="D3609CE06021EE38" modified="2024-05-29" version="1">MILPKTLITWLPLAVGNVAADPAPPAMNFLYSVNLTFNALTTLNIGNTSMGRRVAYPISGGTFVGPNMIGKALYGLDWGLSDFNGAFREDTVYYLQTDDGALIYVRANGIRKNVHHVFETSSVRYAWLNTAVGFAQGRQFKGGVGLDVWQMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJ98</accession>
    <name>A0AAE0KJ98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_547023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJ98"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="20469" checksum="1CB777482CB6BA81" modified="2024-05-29" version="1">MSRQPPPVLIDNLHVQTEEGAPRGEYIDLPPGSHEHRVVERIIHLALLLLESRNGRRSLVEVARNIIEARNDLGIPHIYNRSIRDLPNIIDFFLATMRRNFPTTYLIFGQGGKASGMKQGGTDNMDDFNPRDTGYMTLNRVIIRNMVECLLPGQPATAGHNYVKFKFQMQISVAHEIVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJH0</accession>
    <name>A0AAE0KJH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW/HypB/UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_495588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJH0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="379" mass="40924" checksum="A71D8B20EF06994F" modified="2024-05-29" version="1">MAAAPIPITIITGFLGSGKTTLILSLLPQLRAANPDYRLALLKNEFGDLAVDSQLATSGAISGVQELLNGCICCNLVGQLSTALAELRASVAPDRIVIETSGSAFPATLALEINRLARETGGAYALDGVVSVLDVENWKGYEDTSYTARIQARYTDLIVFNKWESCGERRFDECLDRVGDLELDVAWVKSDKGWVSMDLVFGIDGGLAQGLTDDYHNGGGSHDHHDGHDKKDDDHSHDHQSEVEVLSIELKGPKGAAVDANKLQTLLKSAPKDEVYRIKAVLTASSAVRDSDEDAALPTPPGEHPHNRYILNWAFGRWTFTPIAGEVAEHESSSEAILRMTMILARHESTKWKKKLDAGALLALAGSPDQESLTVAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJW1</accession>
    <name>A0AAE0KJW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_451474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJW1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="9">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3377605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="100" mass="10819" checksum="A1749BAD2333EA68" modified="2024-05-29" version="1">MKSRSGIAPTAAVLLQTAGLGAEQFGGFRPSPRCAANCDLGFVTSWPNLCAIDLNQCSCTSRKVLDTYTCYVNAACSASEAQEAFWFFQTFCARYNIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKD9</accession>
    <name>A0AAE0KKD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UvrD-like helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_221714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKD9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12949" checksum="E759976332D925FC" modified="2024-05-29" version="1">MSAEKNVFSTTLLTIADPHLPRIRGLFLKLMFHHPHTKVDHPRTVDGIQYDSRRQFTLTIAYAITIHKSQSATLDKAVVGISQRHFQLGLTYTKGLPVWLCLMNCNAWNCTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKW7</accession>
    <name>A0AAE0KKW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_250817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKW7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042012624" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="32468" checksum="135D84F47FFFEB4C" modified="2024-05-29" version="1">MPSITKTFGVVVAGLAALASALPSVPKMTRSQLHFHEIAKRQNAAAAALGLTDIDILQFALTLELLEAAFYQQGFAKFPATDFQALGLSEKDISDLTAIGGTEEEHVILLQGAIAAAGVKPVQACTYNFGFTDATGMVGTAAVLENVGVSAYLGAASLIADGGILTTAGSILTIEARHQSTIRLISKAIAVPQAFDTPLSPKQVFSLAAPFIASCPEGSNLILTAFPTLAMAPGQAATAVQAGATIQLQSDQAATATFCAFTTGGLPGGTAFSPFAAATGCVVPQNLAGIVYVNLASAGPLTGKLTDDIILAGPMVMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKZ8</accession>
    <name>A0AAE0KKZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family C78-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_238849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKZ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="245"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="496" mass="55408" checksum="66F9CC4C44AD290C" modified="2024-05-29" version="1">MADSAIDDNNDKTYIPCPFCGWSDKKGGEYDMLVHMESMHAEEGESPFIPGGASGSIKADDEDSQFVECPVERCGATMLPEQMDDHLDLHAQDPDNNSGNEIVHAPNYEALPPAASFSSPSSPSGPSRARRASGRHQSHHAERDTEKSTGQAKAVSAWKLLLRMPGSSSKSSLLQRKKTKSEDDTVGSTVNGITRLGRAQLGRYYNEDRMPSSLEAHLRRGVYVKTEGLIPVLAQILEQCPTTKCAYLCHPSVQHFSKLKGEGGFCGYRNIQMLCSYITAAKFAGYRQMDRKIPTIFQIQDFIEAAWDQGINPRGRIETGGIKNSRKYIGTPEVLVMFRLLQIPCDAQAFKDKEPGRAESLLMDEIEKYFQSGVEDPAQRVRRTNLPPIYFQHSGTTSQAPADLDVEELTVAVCVGHSLTIVGFERLKSGHKNLLIFDPEYHDSSKVTRYIGRKDFEISYPDAALMRYRRGHKYLGRFREFEMIRLKEPDIGFPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0W6</accession>
    <name>A0AAE0N0W6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0W6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodopsin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="11932" checksum="33D46384FF7668FF" modified="2024-05-29" version="1">MLFCLGRDTQVYIARIRTRYHKGVFGAADYTITVAMVAKALSASFTTVAIQHGFGKHTPTIPDGTAGLVTISNYLLGARRTGVIASGFARISIASLILPILRPGWRRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N203</accession>
    <name>A0AAE0N203_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside Hydrolase Family 61</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_504698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N203"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042028431" description="Glycoside Hydrolase Family 61" evidence="2">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="35065" checksum="4C9826B5CB1DDAB0" modified="2024-05-29" version="1">MFTCLFAPALVALLAGSQLAAAHMEMSFPAPFRSKFNPNVAGGDIDYSMTAPLDKSGSDYPCKGYHKALSTAAGKSTATFAPGSAHNFTIVGGAAHGGGSCQASLSYDGGKTFTVISSIVGGCPLSANFPFTIPADAQTGDAIFAWTWFNNLGNREMYMNCAAVTIGSESRGKREEPSSWVEIEERSAYSRRPQIFVANTDNGCTTVDSADVLFPNPGPDTVLNNPAAKQAAGNCGYNGSPAPGSGLGSGSGSGSSVATALPTPAIKSTSSSPPQAAPTPTAHTPGTTCTNEGRWVCNSEERYQRCASGEWSPSLSMAEGHGPFGWSTDVMDGLIESARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N296</accession>
    <name>A0AAE0N296_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_403532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N296"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="624" mass="66535" checksum="BC975886DF5110F3" modified="2024-05-29" version="1">MATAKRSNITVLRKSRVVHYLHHRLHAVLFLAVLVIPSLLTRGAIASAAGCGADFLFPPKDIQHDFYHLDSIEVTYRSNFSNPTLSCLCGAPGQATQKFKADNAGPFNGSAVVFLNFSSTDPCWFHLRPNTGGCGDSSSTFFLADPTATATATANSTSLPSSPADLASLTASSTAVAVASQEPQGGGNNLSPGARVALGIGITLVCLAVAAMAAFLYFRRRKRGQDSALAGAIVDHDRRSGRKAPEKALTRNGSTSMASGHSEEPLYPIQPVFDGYPGSMGYDDVRSLHSSINSHSPTGPHSPTLSHNGFWGAERPDRPEPPPIRYERSTERDELSAARLNSQPAAVVTSYGPNPVTPTLTPRASSRIELNKRAGAVSTDSLEFVPPMPTLSSIPDYTSYRIPPPAPIPEQKLSPPRKYVAPVVVSYGPNRVTPTPAVTSPTVPLDEGVVKRRIVEHAPLPPPPPAPLSAHERSFSWFEGDEPVPGSNTMGPLPPYASEADFNAMKNGAVRTLAAPQAEAELPPTKDGFYHYSTDIVEYELPGASPEHEPQLPFHPYKTHPQAGPSGGGGGGLRDIDEQKFLLSDVEMASLREQKMKIRAAAAAAAAAKPETHESYDLGERVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2P7</accession>
    <name>A0AAE0N2P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_487493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="114" mass="13151" checksum="4BED15AA3F4B0AD3" modified="2024-05-29" version="1">MRRSYTFSESSNDEQLLILRNMLTLLLLGYIGEFEEVDDHRSGKIVVQLNGRLNKCGVISPRYNVRLGELEKWVVKLLPARQFGYIILTTSAGIMDQEEARRKHVSGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4Z2</accession>
    <name>A0AAE0N4Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_315488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4Z2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042031433" description="Fucose-specific lectin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55533" checksum="1A470D4F52AE1BE4" modified="2024-05-29" version="1">MARSGVQERWLLRWTLLLSLAGPSLCGSMTAWWTDIGPSFALQNLTTGEIQYSACNSNNTPLYPNPPNILSTRYKAKINTSLAGTGWYDKTITWASLFYQNNNDDIVNAIYTCNWADGTYTHYESKVISDKTGTPQVHPQSGLSVALLGENEGYRVFFHDKNRELQILKFTQQDLWSYLGPASVNTNRTGMAIHSMFSGLRNVTVVTPRDAANFETVRLNTDGSWAVATFPTPSKITNVTNSTGASNGTSFPYDTSSPPPFRLDEWTANPRALGIAIDTALTRRIFYIGSDKKFHSVASFVSGTTESAWQAQPDTLDTNLPLADTPGGDFAIASDLGTSNIRLYYTVGGVLKEGKYTNGNWFPIADLATKNASAPVSGPADSDSSGLSAGAKAGIGVGVTFGVLLLAAAAVGLYYLGKRQARADVEKEAALTAAAAPKSEVAEVHHAPTAGSRDGSVAGVARTGSGVSKPEWEAEVKDKSPSPEPNPRELDSPNPASELPPTIDRTELPSDRHATELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N567</accession>
    <name>A0AAE0N567_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_318694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N567"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="750" mass="83074" checksum="7E935AE3CC0027CA" modified="2024-05-29" version="1">MFGATSQTPEDHGPPPQAGPPPPTSASIRRYDVERSCIRCHERKVRCDKATPCMTCVRAKVSCRYPGPERTKRRSQKTSSANRLEVLERAVAAINSSPPAGTSATGPSPPAPGHQQHQHQQVMPVGSQGHTPIDPAAAPQLPPQPAAPGSKDNRSESEHSGGFLLKEGASTRYINEFTFSRVLDKQGELQSAIDTPESNHSSDGKQLSTVGFDGLFSSPQVSSADFFSLFPTRWQATQLWQMYLSNVDPLVKILHVPSVQPNLFAAINNPKDTPLDMSALLFSIYFAAVTSLRPHELQIILGQGRQAALNTYQRGLELSLNLGEFLDSPTITSLQAMALYLMCRRNSNSGRSGWILNGLLIRAAQSIGLHRDGEQFNLAPLDIEIRRRLWWQIMGSDGRVAEDHGLSAGPTGGYDGFCDTKLPTHIDDRDLSPNMPAPPQSQPRFTEMTHFLVASEMGQSLHQINQLSALNSPNKMSKLEQYLATVKTRMEGQYLQYCDINIPIQKCALLLGRLLLGKSEVFVRQQSLRGLNAEQSAARATEDMLALACDTIELGIEMKTDELLNNFQWLFSTFTDYHLLTYLLWHLCVRPETVGVDRAWGVVDRLFKLVQTQGWPTPGSKWNVLGKLREKAADIRHAVKFQAERAMARSMAAAAAATAADLATVPPKQQAPAAADLQQQHVDQQQQQAEQQRQAEQQQQQQMQQQQMDQDMLDAVNGTVPMFFPDGYIWDLDTLVIPEWGGYQSGYQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6P7</accession>
    <name>A0AAE0N6P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">B0H63DRAFT_527559</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0274">FAD</keyword>
    <keyword evidence="7 24" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 25" id="KW-0349">Heme</keyword>
    <keyword evidence="14 25" id="KW-0408">Iron</keyword>
    <keyword evidence="17 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="26">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="27">
        <location>
            <begin position="250"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAK3372731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="494" mass="54336" checksum="122AEB362231D89A" modified="2024-05-29" version="1">MATETKTFTLADVEHHSKTDDIWVVIRNKVYDVTKYLEDHPGGVAVLQEIAGTDATVAFDDVGHSAEATDELKLLYIGDLAEEEHIEVLEIFRPTFHQVEQIAAVIVPDKKSKKTSRHLVRGVSILSLGLALSIGGAVWTGRTAELIAALRRPLSLASSYIPSSIRSDASRRPGLFWWGFGIATVADIALSISLGTWVLSKFDVQEEFTHFAPRRTATAAGYMPILKVPTSFTRPKVPKPAQATRVIDPQEWRLFKLVRKTLISPNVYRIVFALPHAHSVLGLPTGQHIALRAMINGKNVARSYTPVSNNTDLGRIELVIKVYEQGLMTKHLEAMRVGESIEIRGPKGAMQYLPNQYAKHIGMIAGGTGITPMFQLIRAICDDEEDNTTINLLYANNTEEDILLRSELDGYVEQCPGNFQVHYVLAKPGPNWTGSSGFISADLIKERLPLVADETKVLLCGPPPMVNAMSKTLVAQGFKAPGAMSKATDQVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6T3</accession>
    <name>A0AAE0N6T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="13" type="ORF">B0H63DRAFT_293778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6T3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="11">
        <location>
            <begin position="165"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="12">
        <location>
            <begin position="862"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="984" mass="108879" checksum="AFB3EED4190E9DD7" modified="2024-05-29" version="1">MSGAHDMPGLLLGDGLGVDADMHDITLHDVDLFGDPVMDSTLALPTRPLPSKQLLQRLDELRTRGCCQGIAWSRQGTIASITPDGKSIDLRFLRCRPDSGTWELTSSNPWSTVSPPLQGGPIVHLAWASTSSPELAVIDAVGRVTILSFSITLNRSYSVRRWDSDPVDDLHAVVGCYWLPLVSANRSFNVTHGQAVWNQSDYRYDNFISPSMGPFHPNPGKSALLCITTNGFLKLFFSQNSNRIEETDIELENITSSEDLITHSAMCSDKNTVLIAMATASKQLKIVRAIIHWGLPQPTDKQAPPGSMPLHPTIKDSHVAVTSWLQHGAGNTPLDASMTQLSHIELLPAAVEGQPPTLSPPLVLTVRSFVPNETSPFSQEPQSIIDRWGIHFDQSQSLHPAFEQLGSKNAPRPPPLTPRLRKLESIIMPKIIVSIHQLQLGKVLCFVFSDGTLQYRDRITMNETLNETNITHITSLHHVGFQFFDASPCLQVAFSPTNCSFVQVCEDGTLKWNRLNYPMEDPTVALQDPSQYHAVLAGLSLALAPSAVHQTNCDDILAIARPFSQKTDFTYAWIREIVKLLKFSVDYSEESHHDQLVRNHHLQLCLSILNHLGFRGEFEPRSFGGKFAMLALNVRNIVILITIASNTPINLKGQLSPLDEPEVVEALAGCAKWAVDLLSWMTDCLYRLLDDPIFMSILSDPKRFPELANYLQSQGDVSLHLLLCSSTRGFLSAACRRLTHLQSLCTRATQFYKNASRPPSPLKNAYEKMQHSTSSSLVKVHKFDNLVGGLSEDIRSAYRRTLSGLVSKPKPQNGTGNTQQGQDGNEQLVKKAQAHCELDMLLAANPPPGFREVLFNFFNTSLPNFRVQTDPARLYFGNYDLLEVEDNPKILAAKKTAGKYIDVFKRVEIYSGAGTVKNALSKNGGHANGAGEEEGPRWRRCVRCASVMEDVYGQRPGFTFVLAQQRKCSCGGNWGLLPRGSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7A1</accession>
    <name>A0AAE0N7A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_453461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7A1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="374" mass="42045" checksum="BDCB9C3030CAC770" modified="2024-05-29" version="1">MANKPTPAGLLDDEDTEPGVPTMVARLQKMDRQMKRVSEEAAASCCYLRRARTQLGLWPAQPKAGGASSAMIREHSHDPLFIKPLSWTSQDLEILGCEFVKLDRPPGEAVDGRSNAAQNDANKKDNKILEAIQGIFHYSGRDPKSWVVNRLLQHFSIFELPVQFSQQKPVHTLFTEGILTAGNVCDAAPVIAYLGLESDSIAERRNRVRATQRASPPCKPMAVSALLESSFREKLMRPVQPESELEDPFLAAVMIALAQQLHMRRRPARAFKVHILTLADSPQEEPTLFFYQSVISKELLERLDRPSLYIPARPITISHFQMPLYPYEEAIDVVNRFLANTDDGMTNCIAALTRKEILNVTEDPVTNYIIYHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8Y1</accession>
    <name>A0AAE0N8Y1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_269753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8Y1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21523" checksum="BC680C3C404D092B" modified="2024-05-29" version="1">MASSLPLQVAETIQTAHINRDPSAAHDINPSTAASRKEPVVLDNGTAAMSSLDKPQNYEYDDDHHHQDFLDGDGIDEGDNDNDDEDIPFSVLRPRPRKAQLPPIPDLRYEQSYLHSIRNVDRWGKVLWITARDQMMMPFVQGVIYNLGICGWQYWNKNAQLSGSSIGARVRRWWWGVNNWAIPGEKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8Z0</accession>
    <name>A0AAE0N8Z0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_269769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8Z0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="630" mass="70270" checksum="0977B11CB6E8F0B0" modified="2024-05-29" version="1">MADDDSSDLSSISSLSAPPSDDETDIQLERKHGILKFFHKVDQNPALEPKDSTPPRPKREPSPPHEYVLADNADIAFIVMFRGRFTDAFPKSLPNFGPQELERDIVDSIPGERVVHFLCALLGLLLNRKQDVKPGHYNRALEEAIQTHKGQWAKDWESQNPLSGSATFASMAPVQRLTLLRTLVQWALSSSEAIKSTINQQYKNRQDDDANIPLSVQPWGSDGDKRRYYLIEGNDDTGFRVYRESNPAGINRTWWNVAGSINELKSLSERLEIHDGGPKARTLARKIMSSIPRFEATEEKRRRREYRQQRKEQFKRPEVGMSLYEGRTRGKRMKYTYSDDEADFYSDSTNRRSSRNTRNHTPAEPAGPVTTARGRQIRAPTRLNADNGSSRGPSAPASVQGDGYVEDTGMTIDESMVGRGRPRRSAAVNHGMNGWAKKRKSQSDDESDESGEEESSEPDLGNDESDDEEEFEAELELDDELEESPYASDSTSPQDASYVFKFPVRVAFDDNNKVRRIPGPPIVTETRKHPRAAHRNIIISDESGTSTPDDGESEEDLAPQPEEPAAEVIAVAFKRVMPNNSEKNPPGSSGTPVKSPLTPGSSAPSTSLTFRGSPEKPQHIPSTIDMGHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N904</accession>
    <name>A0AAE0N904_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_271749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N904"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3375221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="23862" checksum="8A17145D32888870" modified="2024-05-29" version="1">MYHLAKGLYRLATSKEEYSVVLLGLDNAGKTTFHEQVKSIFLPDNPEPKLKTVPTVGQNVSTIVLPDMYLKLWDVGGQHSLRQLWQSYYASCHAIVFIIDSTDIGDGNLEHDSSGRLDECRLVLEDVLQNSETEGVPLLILANKQDREDCVEVVRIKEGLVKRVFEGDKASSIRDSRVLPVSALTGTGVREAVDWLRSRVKWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N945</accession>
    <name>A0AAE0N945_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_482676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N945"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="236"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="592" mass="64449" checksum="48DE2CBBFB400EED" modified="2024-05-29" version="1">MCLASLCIRIDRSRSPDCVGPCPSSRFAFPLRSRLDQYPTRPYSTYLPTLNFHPPRQLSGALSSLMTSICCTSSRRGHWRPLVERLRLSATRSSSSSAAAASLVLGSYLRPRRARSSFHHQLVPFTISPQQKRRTHHPQPVHPNHGSLIPSDDHKHTPSPSRPNCSLTNSSSYLYLAPQRPTTLRPSNAKILAAMATQTRAHSGHSHSHAHHHHHHDNVYLTSQNKKDAGVRITRIGLYSNLGMAIAKGAGGYYFNSQSMVADAWHSLTDLASDVLTLATVSWSLRPPTKQFPLGFGKVESLGSLGVSSMLLFGGLFMCMNSCTSLYAHLLLDPDAAAAMLEHGHHHGHSHSHGHDGPSLHAAWLAAGTVAVKEWLYHATMKVARERKSSVLASNAVHHRVDSLTGIVTLLAILGANFLNNAAWLDPIGGLLISLLVIRAGWGNTLSALYELADRSIDAEVTRSIKRQISSALSAEAVPEVTVRDVTGVKSGQNYLVDIELAVPKAWTVEEVRGVEDAVRAQVGAKVRGVRRVRVRFVPLDAGALAAEKSFDDEFVSVDISPRTSPEPESEDDDHDAAHNHGNGNGDNKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N950</accession>
    <name>A0AAE0N950_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_496532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N950"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3375356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="921" mass="101003" checksum="AAD5A39F6E681B36" modified="2024-05-29" version="1">MAGRIPRLRDHRGGSDVHDGHDVEGGSSTDHQGYLSLPGSPTAFRRQPAITTDAGSRSRSRRPSNSELPDERSPLLTTSRSRIRIHSAHGSPRVPNLSRNQSYADSVRSTRHHSRANSWGQRLIHALGDRQESSMAESKGSIFPDDRVWYDQFTSTDWVHDSIADAYRVKALRSRKDFWGRVYVLFDGAQGWILSALVGFVVAVIAYVITVSEATVFDFKEGYCARHWYIGEKKCCPHGPCTDWREWAEVLNGYPFGERWTEFVVYVTLVIVLAVLSCLLTLTTKTVVPSAYRLSTLDENLAAESVALPAENEADEPSVSPRQAADVPGGPPMIYYSAAGSGVAEVRVILSGFVLHGFLGLKTLLIKSVGLVLSVASGLSLGKEGPYVHISTCVGNIACRLFTKYDRNDAKRREVLSAAAAAGVAVAFGAPLSGVLFGLEEVAYFFPAKTLFRTFFCCITAALTLKFLNPYGTHKIVMFQVKYVLDWEYFELVGFVFVGVLGGAAGALFIKASRHWAKTFRRIPAIKTYPLLEVVLVALTTGLVGYWNVFTKLPVAKLLYNLAAPCDDRDNNLEDLGLCPDSIDDIPPILLSLLAAFLIKGFLTIVTFGIKVPAGIYVPSMVVGGLMGRLIGHVVQLVVLKFPVWGIWGDCAKVSSATCIQPGVYALIAAGSTMCGVTRLSVTLAVILFELTGSLDYVLPFSLAILVAKWTADAIEPLSIYDLLTEMNSYPFLNNKHKPIFTSDLADIVPRVRKERIIDISSSPVVPALSLRTKLELLHRAGELDGGLPIIRDGFLVGLIPAPDLEYALDNLDDESSSLCLMAHVPNIDDSDDGHPDPTDFTPYIDPAPVALDIRSPMDLVYEVFVKLGLRYICILRDGRYAGMVGGAPFSGFAAWLTMNQTHKKTFVKYIRELEEKEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9A1</accession>
    <name>A0AAE0N9A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_262115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9A1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="136" mass="15052" checksum="8039966824B4FB6E" modified="2024-05-29" version="1">MSYILYTASFAALAMGTVLYFTRARWLPSVQETFANLNLPGQNYLYSALPGSTSNTFSGDMEAGLSSSTFDLSGNVADGDGRAGLDNAAKREILKIMKRRRLRFDEARRVYMEQRFQANGIGADGRPKDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NB34</accession>
    <name>A0AAE0NB34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_495429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NB34"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="225" mass="26539" checksum="4878D4721744D2AA" modified="2024-05-29" version="1">MVGCIRYGAYFMAHLKDYVKATSPVMHFLTYADNYATGYFAKQGFTEEITLDKPIWMGYIKDYEGSTLMQLSMLPRIRYPEAGPNIRALSKRHIIHQPPQIFPIDPLSIPAIRATAWSPQMDELAWIPRHGPHFNEPRRFLYQIQNHTQAWPFLAPVNRDEVPDYYNVIETPMDLSNMEEKLSHDAYNTTKEFIHDLKLVFSNMEKYMWTLTKEIPEWFDLLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCD4</accession>
    <name>A0AAE0NCD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_219750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCD4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041988810" evidence="2">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="220" mass="21849" checksum="0D13E8BC73BE165D" modified="2024-05-29" version="1">MHASIISIVLVAFLTHEVSAAPTTRTCTAKNATPISALTGSNGIDLNPDIDSLIKRSFTSSSSLQKRADSVECYVDEYCAETKGLPFCYETISGRMRDTEGTVGNLITGDYTLADGRKGNMYKGPHPQPGDGGASGETATKTTSTGKSKATGASGSSGTTGTSGANAAGITDAPTGTAAADEADGTAPATSSKNAGMPVYGGASGAAVGGMIALLGVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCF0</accession>
    <name>A0AAE0NCF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_399232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="3">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1680"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2003"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2009"/>
            <end position="2022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2022" mass="221554" checksum="EDA282FAD72A9D24" modified="2024-05-29" version="1">MDLLSTVRKQGSRGGVNFSWDDVATSAHRENYLGHSLRAPVGRWAKGRDLNWYASAEPTAAGSGETEEEKLERERLEEIRKLKEAEEDAINRALGLPIMPRIVTGANDRNTEIRRGGTGGGTAAGIEVGIGTAAGMIGLGAEVAAPKNIPTATTGDGIPTEVAAGRGTTKDENTDDTVAAGAGTGDKSRNRGITAETGAGAGTGDQGAMITDNGEADLSQTPGKERRRAAKLKPRAISSTRHANMDYSRLRAAALKDGEDEEAVTVDTRALIDKVLARYSGEWTTLRELIQNAADAQATTVKIKWDTLPSTKVPLPATTNQSEILKHALTHHTLRRLVVQNNGQAFSSKDWARLKRIAEGNPDETKIGAFGVGFYSVFADCEEPFVSSGNEAMAFYWKGNALFTRKLQVPQGEGSSETAFVLDYRNTTTPLPTLLSVGQFLATSLTFVALEHIEFWIDDWKIMALQKKSSPSVEIPIPRDLETKTKEGLMKLAMADRTSTQIDAKFMSVIGWKPQASASAAKPTDYYFGSNTSELPSLRTFFSRLTAGPSQGRGKAAKEEKAIQEAVAEDLTVTSTSSIFLRVTSAQIVTNVSALFATELERATKKPPPKTTRIAILTSSHDETLASEKSSDSSRTAKAVDVFSSVLPSKKPGGRIFIGFPTTQTTGAGMHISAPSVIPTVEREAIDLNARWVRTWNMELLRVAGIMSRLAFANEMSDLNDKLRRMSNPANTKGSAISPSDVEKCVPEGFHILKTYTFGDSTPSGQVAQIIEEAFWTAFKRPTIEVYSSRGVLQTSKVRASSDELGKFVAGIPVILKDMKDAPFIKKLRDFGLIKDITVDDICEELGSKALDKDQLHHFIAWAARSAVSGELDLTSKQRVLDVAVATISDGGDSGDIIALGSIKNYLNNKIPSTLPIPPSTLPITYTASIPEVQLQALGWEPLGIVPWLRFVIESGPNKDEEQNLTKSAKFSLQVLAVLSKNWDNLSPSSKSSVISALQHITAIPTKMGMRNPGESFFPSVKLFDDLPTLQGCQNIKEKFLTALGVRKTVDLETIFTRLLNPTPPSGEAVHKKWSHVELIKYLASVKDDIPAADMKKLTESKLVPAEAGPRGMESTAGTTQLYRVSELFEPKDTLRTLKLPILQWPGPPGSFRNTSIEARFLYSLGLRPFPSVPELVDMMASPDLELRRNAMTYFIGNHHLNGYASFDLAATNKAILPLDGNEKQLVPPSTCYTNERAAVLGYNILRRDLHQHANKFGVTREPPITGCVERLIAKPPRDRSMAITLFEYFTTRLGDLGQNHIVKLRDTPIVPVMRAKGASGGVPGKTEATLIHVRPQNCYLGSSSTYGDIFDFVDFGTDANTFLFKCGAKTEPTKPELAQLACGEPARLLSVLQSSEKYLNLLRSLAEDLPILKRDKDLFRKMKTSFWLLGSREISSGTAKQSESYEEVEAPIKQYQLAAANQIVVLDDYISYQLFSQSLLCAPEDDALEAFYMALGSETLGSKVQEDIRIGPHAEKQDGAEWLRKHVLERSKLFLHEYSKYKRDSIKHDAKWLDKNLRIEAVRTVALRRSLKGHGQSHTEKRSAASNSAGGTWVLYVAAEGRPDMYQVGQAVCQMLLTRPSQQAYFFFEPFLKLDLLDLRSRGYNVDRILRAKAAEARIAEEERRKALEAEEQMIQEREKEWTRQTRASAAEAAREQVKTPEHRMPGAFNESPEAESAPGPSQPRQPKRGLFSNLTRRLGFESDEASQSQLDKFISPPEQKGSSAGPTPVHGEDRGPNKDDGRVTSPAVVQQNLLNAIKSTRAHDSTQLFSPPEQNEVKEQATYCDAKPATNINFAAEAPGGMRVFVAKDLSVEPMTFLSSNIGPIGHFETLLREIGGIYGLSTKSVHIFYDERGGTIAFNSNGSIFCNLRFFNQLHAANMRGAGANEAKVEATTWWWVVIAHELAHNLVGPHNSEHSYYTESFIQQYFPKMMAKAVAWTSASAAATAPAVAAPVARASLLPPPPYTRGTNGPTGYQSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0ND84</accession>
    <name>A0AAE0ND84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B0H63DRAFT_247025</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0ND84"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="378"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK3378419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="57495" checksum="BD5406EDE6F6ED65" modified="2024-05-29" version="1">MTTRTASNGANGFLRAEDAERSNGHSNGHTNGGSNNLNGSSTANGHTNSSSTNNGSNNSMKVVHRRKSDRKKSSPMMPTFMVSAPGKVIVFGEHAVVHGKAAIAAAISLRSYLLVTTLSKSKRTVTLTFPDIDFNHVWNIDDLPWSTFSHPSKKKYYYDLVTTLDPDLVAAIQPCLANVSPDKPSEIRKVHQNSAGSFLYMFLSLGSQSFPGCQYTLRSTIPIGAGLGSSATIAVCMSAALLLQLRTLSGPHPDQPPDEARLQIERINRWAFVYEMFIHGNPSGVDNTVSTQGKAVMFQRTDYSKPPKVQPLWDFPELPLLLVDTRTAKSTAHEVAKVEKLKKTHPKLVGSILDAIDKVTESANGLIDEEDFDTENEECLRRVGELMTINHGLLVSLGVSHPRLERVRELVDHEGIGYTKLTGAGGGGCSITLLRPNVSRQKLDRLEEQLDEEGYQKFETTLGGDGVGVLWPAVLKNGMDEDEEGGMEIDLENFLKAEGNEGVERLVGVHGGVGEREGWKFWRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG28</accession>
    <name>A0AAE0NG28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_501729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG28"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3380863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="32069" checksum="D5AB7F22CE014158" modified="2024-05-29" version="1">MGKNFLSCVSYQFGILYFKGCSPIKFAIAPERASRSPCPVVNALANHGHLERSGRTIYMEDLNASMRHVGMSPLLGSVFAIPTYFEYHNPAKAYMKKPVGTWQRIWSLIKNLYSFFDYFGCWKAHQAIEGRKFLNLEDLASHGAIEHDVSLSRRDFGQEQGNNDPQQDLIHEMLEYSFDGESLTIDDLGRFIKARIRRQLVDNPELVYGPAEHQVNCGQIALMMDCFGDGKTIPVSYVKAIFEDERLPIEEGWKKRYWWTMGLIEFFGAVGNMVKAVGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG81</accession>
    <name>A0AAE0NG81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_396365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3380914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="334" mass="38269" checksum="57322B217CF07BF2" modified="2024-05-29" version="1">MTLTPVARVTQELKGQTLYLPNLKPYFSQWPTEISPYYEQLKVTIESKIQEWISPVDERVRLKARKVDLPLFCATWYPRSTLDRLETMAWFSMWLFLWDDVIESTVVSTTSAPTNDVAWLHDQALTYVAFHLGLSESVDEPPPPTKYCTLFKHAGPALRAECTIAERQRFHDEIRYYMKGCEVEQTYVRAGELPTLHAFWENRIGTSSVNMYCSLGEYMAGTHIPAELYETEELKTMWFELNRHISAMNDIVSLKKEIGKSLHSLIPVIINETGVDVNTAVGAVIETLRTSAENVDQGAKALLRVTAHDPKAHASVQKYVMAYWTNMTGSYWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH10</accession>
    <name>A0AAE0NH10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_203851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH10"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="233" mass="26339" checksum="FFBEA7A2A4446B04" modified="2024-05-29" version="1">MSPTPPGHYWVCWGGRRCRSEPMLSYLSPFCNAGRFPGLAPFLLLPELRKKTEYCWAAEATAGRICGELEIFWISLKSDCCRARSGSGHPRCCCCTNPPLQSQLPIFFLFVISITGREAVTYWTEPRHDSSVCSEKWRERCVNAPRLTLKGPGPGLKLSYPRIATTMGGASLMAVEIDSFLKSRRHSGRQWKPRLDEVNGRHKVTDNSFSIQIHEEILPKHVSTTLNQRWSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH56</accession>
    <name>A0AAE0NH56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_434908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH56"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="304" mass="33503" checksum="9BAD3E0BD33FC747" modified="2024-05-29" version="1">MTAGAQVIANSGHDDMIHDAVLDYYGRKLATCSSDRTIKIFEIEGESQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVFIWREQGGSWQRIFDFALHKASVNIVSWSPHEAGCLLACASSDGNVSVLEFKDNSWEHSIFHAHGLGVNSVSWAPATTPGSIVSSNPGPASTGNRRFVTGGSDNQLKIWVYDPSTNSYKMEREPLTGHTDWVRDVAWSPTVLQKSYIASASQDRTVRIWTSDAANPEKWNCKVLPFEAAVWRVSWSLSGNVLAASGGDNKVTLWKENLRGEWECVKTIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHH8</accession>
    <name>A0AAE0NHH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_209075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHH8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="575" mass="64734" checksum="1D2247BAA23516CC" modified="2024-05-29" version="1">MSKVIRSVKNVTKGYSSVQVKVREATSNDPWGPTGTQMSEIAQLTYNSSTEFYEIMDMIDKRLNDKGKNWRHVLKALKVMDYCLHEGSELVVTWAKQNIFIIKTLREFQYIDEEGKDVGQNVRVAAKELTALVLDEERLRAERSDRKSWKSRVTGLEEYGPQPPHQEPARRQRRQFTDEEDAEYKLAIEASKQQEEEDRRKRLSRAVDDDDDDLAKAIKLSKEEEERRRRELEESNVSSLFDDEPGQSSQPQRFNQGYEQGSAVDFFANPIEQGQMQVQPTGYMPNAYTGFPAQQQQTGYPNSFQNGFGQQQTAFDPFGQQQMPQQTFQQPQPTGYNPYAQQQQQQQQQQFLQQQQLQAQQQLQAQQFQPQTQESSLHAGSNNPWAGNSMQTGIKPMPTGSNNPFAQQSSLSRPQAFKAPSMPSLGSLPEQKTLSTFPQNQTTYNQPQAQSIPQFQPQRETNEHEARLNALLASGDGMDTFGNTGNLRIPAQHTAPGTFVNSAGAGLSRMTADATGNNPFLRQQFTGMPNTSYGGQQMPAATGPVGMNGYGSQQTNNPFAGRQQQQNGQGDLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHL5</accession>
    <name>A0AAE0NHL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_476419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHL5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="69990" checksum="3640474E6CA02C4A" modified="2024-05-29" version="1">MPRLEALVYKGDDDDDVVHNLQRLELETGSSSIYSQSSATSLLDQQRERSTGGRYSPPPATPWFSEEDELYRARTLEVAQSRRPLTPSTRPSSNGENLARKDSRPRISERRPSKASSHTVGGYSLYPPTKPLPPVPNLPKGSRRASSQASFDGYAAEATSPSSFETSRFSQQSRTTSNLDRDSVGNSPHTTTAPPFLPTSTAADRRKAEALTGVSSVDLAAWKILTVPKNEKGLKEPTVFWVDISTTAATLATKHGNNIVKVWSVGSSEVQSTIKISCYTTAQSRSREYFVRSHAILSEPSTMIAITTGFGDTLEIYDWAKKKKLQTIDKADRWAAVRCNVFESGWTPLVVYHGDDDTIDLYATTHSRKPLKKSRTIELRKAGLPLLPKYPELAFSSTGPLLVAASGPRPPRLGHPPPERETLLVAWQIHDDIEEAPSVPYKVVTPWQHQELDTALPCGLATYGSVAVSIWIPASYRAVPVPASRGGQGYNLAPAAVPFRYVLIWDFSASSTRTFRIPNAISCVSPDCRFIAYCDASGANVGARGNLVILDAMAGKQLWCWPDPDATAMDSGPQMGFEQFEHLNRVTDLSFSGDGGFLFVGDSEGNVGVYEVREREAGHRMQLQVTRNSQHSRSDAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHM0</accession>
    <name>A0AAE0NHM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_209406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHM0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="196" mass="22362" checksum="3ECFEBE8F502EED2" modified="2024-05-29" version="1">MCKKNRWLVLTKGLICLVLMINTCGEIDFLYSLHYDSVDPAMTMTTKRSRILALGWRWKSGGCSEPLEGEKSLSDRFMLRQHSSQRGTRKDFGRGGGGQPPFPTTYYFPYFQWGFSFPNGGLQGVRWLDGVKAIIARGRKCIGFWETKQGQRNVTARHPRTHANARTTTISMQAVPVLCCNAAPLPQSHRRWWKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHN0</accession>
    <name>A0AAE0NHN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_546352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="53158" checksum="19185FEC0F5CA05B" modified="2024-05-29" version="1">MAIFNYTIAAAAAALLSTLSPVLANWQYRSRPDLSPPRLNITIPAHDDVAPGYLFVAPYSAFDGRASGPEQPTAYIFHNDGDLVWSSLGYLAGWVANFFQAVPYQGRPVLQASHGSLDPFHGHGYGTVALLDHSYSPVATLQSLHKLVSIHEFRIVGEKTALVEVSQPIPYDLRPYGGNESQQWIVDGIWQELDIETGKLLFEGHSLDSQESVIPLTTDKRHPGTTSGDAWDYFHLNSVDKDDEGNYLISSRHTSTAYKVSGVDGSVIWRLGGRNSAFPLSNDVSFAYQHDARFLSRSADGAIETISLFDNAALTDGTKIRPSSSKYSPPLMTYLQGNAQVLPNGNVFVNWGQAGAVTEFRGSGAEPLFHAYLDSGSLGPGVQSYRGFRYEWEGRPRESPAVIGLQADSHTAVYVLWNGGTLGAVQRESFETVFVVSSTGLQTLGEDVRVFAVALDAEGHVVGRSSGVSVQDDIRPTKRVPGKPSHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNJ9</accession>
    <name>A0AAE0NNJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_471704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNJ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="104488" checksum="872B52631F695B9F" modified="2024-05-29" version="1">MTNSWSSRPYMAYVGQSSGAEADQTGPAAMPSALKPGLGQPPPVKQPADNMPQLGATFVPGGFDDYYMPEVIAPAPQRVMPEVPQNMQEDLQRMELEAHEAAPRRESTQEDKSFKPFPIQKTGSVLSAMDAPSFSPFPKIKGENIPPSDDEKEGILWQARALVLHSNNVSMQVTWARDTLSWVEVAQDAQAREWKRTGKGRDRPATPKTEHELRVDAVNILSYLSDQDHPEATFMKGKWLEFGKFGFREDKREAYAYYKKAARFGNGRAEYRMGMLYELSNDIPNAIKHYLLGTEKNDSASNYRLGMMHLMGQHGHQRDFLQGLELIQKAADTADEDAPQGAYVYGMLIARELPDITIPETLLPCELSVARQYIEKAAYLGFSKAQLKMGQAYELSQLGCDFNPAYSLHYYGLAARQGQPEAALGVSRWFLFGFEDVFPKNEALAFKYAQEAAETGLATGEFAMGYYYEIGIHVPKDVREARRWYELAAEHGNSDAKQRIDSLSQSKTLTKQDHETTTLTRIKSQHGSQRGKRPDRFNKPAAILPTLSESTPVEDSIDFPDPERPHTMIAARPPAFQLNIDQNLPMRPKSAAPYPLGDRPEALNLRPKSVAPYPEDDTPPLRPSSQHYNSAAARLSSGPHADRPGSAFGIRPLSSNSGPPPGQPGPERGTYPPNPPQGAGWQPQVPPGYRQPSTGPPPRQDYRNEAPQWQQPQHNLPSQRVGAAPVGPGVTVPAGAAPVGDPNRNRLQKYNPHVTNPPPGPQKPQGPPYGQQPPAAGYAAQPNLAPGPGGQPGRDYGPRINTRPASDTYDRYDRYGAGPPPAGRLSGSVSNGNPQPSRVDSYSPAHGRLPSTGSMPLKTRPGQLESMSGGRSSAPPAQGGRPYSAVSQGPPSGPATPATPATPAPSVASTTKLPGHGGPARPGAKPHVPTNHPDGKTMGQGPATFEEMGIPQGKHEGDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNM8</accession>
    <name>A0AAE0NNM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_448928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041936995" description="Peptidase M24 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="199"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="481" mass="54120" checksum="81923B878E72B39B" modified="2024-05-29" version="1">MRLTWAGVLAALLVRVTAVAEPESWPHLPRYYTLPSLREQADIQDAWTRERRDKIPAILKKHGVDAWLVSQREYAEETVFWSLKSARQFSARRRTTMLFLASDNDTTASSYTWVDNTPKLWDELIHILDARRPRSIAVDVDPQIAFSSGLHAGELKAILAELGEHWIKRLVSKPLVAIEYIATQPKSRAAWYRRLQSTAWAMITEAFSERVITPGVTTTADVEWWLRERIQEMNYTTWFHPDVTIIDEHAWNLSSTASMMPSAVMMGPDLEIKEETGNVVNYGDMLHVDFGVTALGMNTDTQHLGYVLHPGETEDDVPRGLVEGLRKGNRAQDIVKANMKIGLTGNEILKNVLGQMHAEGIEGRVYSHPIGDWGHSAGTLIGMTNLQDGVPILGDIPLLPSMYYSVELLVEHFVPELNATLRFPLEEDIRHVSSEGDGSAWLWAYGRQERFHLVHTPLSSASSARQGHERLGFNSRGGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNT2</accession>
    <name>A0AAE0NNT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_174318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNT2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3384946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="741" mass="82099" checksum="E023CC9CF12044CF" modified="2024-05-29" version="1">MDDGQGRSGLARFACDFCKHKKIKCSRELPKCAACKPWPGICDYSRRPVSLGAPKPEIMPLPQPETVPISLGLPVHAVQRIEANSAAARLEKVEAALESLTASVNRLLAASDPQDTRGREKECSRVDSIKSIALGSPQTGRAKSPISPHSFSAVGEADSQLGRILPLLKPQPDYNIAVNGLQDLTKDLKNPPCPPLSTVNSNFTRAYIVPDRETGLWMMHNFSRIMRLTKVYFDTPSDELLQQVIFKPTEAPPAWVIFVSYLLLAAPDSTDPGTLTNLLRWNTKLALNHASMYLVPCNINVQALMLLSFHGEDYASPNTSWILTSHACHQAEAVALYSPSTELNREAQQRQLSLFWGLFVLEKTCALAFGRPVFMPTAFYRNVPVPSFDHLAKFNFHLHNSSFESSETTYSPFGAHLFLQNIKLAKLIGTILDVLASGGSLEERDRLRAKLDAWCQETTEILGSAQATERKLFGEKPNGEMSQLVATIKLRATHAMIILVKGLPQYDELRLSGSRQILQLLPQMVAGWHPFYNGVIWQILYYPFTPFFVLLSHVLRNPRGPDVHDDLALLQSLTGHFTNLRSRLTLLSDTSARLAHTAEVFFRLAQRYVQESNAAPFSGFPLANPECPSTPSAPKGKVSTRNLHPESVSGRLVSNPALEDFTFNDVEIDKFMSWLPQDLPADFSSFGSTGSHSEDNAGSTSTARQNAPHGQKRPFEATFDWFSWEQYYSDSGAPSGGSVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ59</accession>
    <name>A0AAE0NQ59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_544061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ59"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="28337" checksum="43B906B4094F3728" modified="2024-05-29" version="1">MASTIVGKSGSVYIQGEVLQQSFVFKRVPRPFFELSLRLADDNQDEGILIYPYFKDTLLALIKKEPDLSLAGRKKILRCVGEAIQEFHSKNWIQIGVKPDNILVNWSCDEAGKTTIGDVALGSFDIAFKSEHGEPRETPHAIGNAMWRSPEGQTGRGVTKASDIFSFGLVLDLLLLSGDEYQQITQRGISPEQEILTRHFSYFGPAAEGLLRQVGSPDWCDALKEASAMAELAAKEQPERRFEHWGPQVPRCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS46</accession>
    <name>A0AAE0NS46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_558320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="47914" checksum="8C53A4DBEE8B92C4" modified="2024-05-29" version="1">MTPPRHPHRIIPLLRLDIHILFSPSCSLHITRTHRFLCCQPQLYRVAKRPCFSNNMDGPNEDNLKQSMPVGRFIPYLPNLSSGIKSAAASPGTAFAIAMVGICLAHGFALSSLFAQKPFGSKPFSNWFLSPSKQSSSSQKDPAPPPPQKSFIKVALTDIAKTFTMQILCSLPVLVTLLFVYVDSSPTAPARKGHHRVGLFNVCAALFFLKKGCSTSGSATFFATLALSMAAASAALAGVNDMGLPIADEGVSVTLSIRNASGHSYLQTMSVASITQTILFYMAWVQALFTLCAMSRKLAGLWAFYELELANICAALLFVRKGCRTSGSGTFLASVALAMALAQGLLLLLTGIYRFGKPVDEGLSVTLSVQDGSGQTYVQAIPIKFILRGVAYQLCLYQAAFTASAMSRKLAGLAALGYVVVKCLESIYVDLSKPREGKDVDNRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT53</accession>
    <name>A0AAE0NT53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_154492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT53"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="843" mass="92619" checksum="B214EA106E69EC4A" modified="2024-05-29" version="1">MKFSHSIQFNAVPDWSSHYIAYSNLKKLIYQLEKAIHQTAGGDAESRPLIQSEDPESVFIRALDVELEKISSFYVLKETELFDEVNAILRDVGTFEEESGPADGAQPRPPVRTRSAERPRPTPLRSGSTARSRGSTDDGVEDSDDDGDETTGLTKKRRVSFGGRRKTLPNIMQASTDMTASTDLTTSRSLRRYSQTYDDYAEQAALFSSGIMLKKRIINIYVQLCELKSYAQLNRTGFSKVLKKFDKIVDRQLRRKYMDSYVDTSYPFRSETTKDLEEKISKMVHAYTSIVTDGDEEAAKRDLRSHLREHVVWERNTVWRDLIGLERRAEAASLGHTLLGRDTDPHKTLLQGDDERVLPTKEIATPFGRFTCPAWLFSSTMFTLLTILAIFFLVLLVPLMEKPEQQNCLALLVLVSLLWATEAIPLFVTSLTIPFLCVVLNVFREKDKPYARLGSKEATAAVFSAMWTPVIMLLLGGFTLAAALSKCSIDKRIATFVLSKAGTKPSTVLIANMAVAAVASMLISNVAAPVLCFGIIEPMLRNLPAGSDMSKAVIMGIALASNIGGMLSPIASPQNVVAIGIMEPAPTWGQWFFIVIPVGVISLALIWGILLVTFRPGRGTTIVPIRPVRDPFTGVQWFVSIVTIATIGLWCASHQLESVFGDMGVIAIIPIVLFFGVGILTKEDFNNFPWTIIILAAGGLSLGKAVNSSGLLHTVAKAITEYVKDFSLYGILVVFSSLILVIATFISHTVAALIILPIVFDVGKGLEQPHPNLLVMAGVLMCSAAMALPTSGFPNMTAIMKEDPTGQRYLQVKHFISRGVPSSILTLVVVVTVGYGAMWMTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTD1</accession>
    <name>A0AAE0NTD1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRF-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_558888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTD1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="2">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="240" mass="26181" checksum="2A6D8BB6C5E2FC97" modified="2024-05-29" version="1">MAFPAFPLPQPPRCLTCGQPCTPQRTKPGNLNGNQGRNYYICFNPQHESHIFSTFDDNIGIGPPNPLCRCGYYTRRSFNRGGGGEFFTCPVGVCPFKRSAMPSSTTATSPPPQPSAYSTPSPYQSPSPYQTPSPYQAPSPYQTPSPNPPQPAYPSNTHVVQSQGHYGYQNQYRYELSAIQPPSQSTGISYGPAEERYQQPPSESTAGIYYGPAEAGYPHPHQPQQNVQGRSSGCCSCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTJ7</accession>
    <name>A0AAE0NTJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_448213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTJ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042249188" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="206" mass="22681" checksum="FEF08894D9A26CE0" modified="2024-05-29" version="1">MFFAKLAALALLVAAALMATAAPSANEETLTHLHGTSVEQYKQVKASWEASNVSHHGLKTPTTTIHESQSASDCSGSFPDPFGNVDCSQLSIVFGDHVTPNDRDIMSVFTKDGKVLFPPSVLGCVVDDIPGDYWNNFTVEGLPHSLDIHPGNLCLRLKYSDHWWDNAWVHYGNQFLNVPTDDRCKGIWPDEHNQDMGQRCLIDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU16</accession>
    <name>A0AAE0NU16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_470784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU16"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="618" mass="67756" checksum="D0CFB5ED88377097" modified="2024-05-29" version="1">MRITSIKLLSPSSSLRLINRTNQFRAAPRLWARNYFAMVSIEGDGAVKPAQAAPAVTTSNDLVPGAKRQYTGNAHNKKPFKKQRRKDKKPAEGSHDEVLMADIIELEEKLAAQKLADEDATAAALPEQGSEIEVDVMELSSTGEGLALQRGSHQIYVVPFSIPGDTVKIKVYRHNEHHSVGDFISVIKPSPLRDDSRIQCKYFGVCSGCQFQMLDYAEQLRRKRDIVVKAYRNFSQLAPELVPEILDTIGSPLEYGYRTKLTPHFDGPPGAQRRGPKVTHPEMPPFGFTPKATRKVLDIEDCPIATDAVRKGLVAERARLAVEYGTYSKGATILLRESTKRVPNGATGEDARTETEGGIIPPIVVEADTFTDYKTCITDNNATSTEYIDDFVFTNPAGSFFQNNNSILPPFTEYIREHILPPASPTAKPIRNLIDAYSGSGLFTITQASLFPGGSIGIDIAEKSIDYARKNAALNGLSDGSSNDGKPICKFIAADAPALFKSVSQYDPDETVVVLDPPRKGCDHSFLTQLLKFAPRRIVYVSCNVHTQARDVGVLVRGQVPGGAKKQPPPVDAFDAILTPAETDQKPVRYDIESIRGFDFFPQTGHVEGVAILSRIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NV54</accession>
    <name>A0AAE0NV54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NV54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3388005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="394" mass="43166" checksum="9EB8F144953F7621" modified="2024-05-29" version="1">MYLEDNPDQAPAAAPQIQAPARDENGPVNASNSDNEMDADPGTPAQYTESQFAAIQDDADQPFSHEQQETSSPLSTPSQNGLPANANSIFSPRPAKRRRLSLGGASSTGLGNQEQASSSPLMTPNHPHNLPAPGSTDGIRPLPSALQMAANGPVLPLPEIKPEISSMSPPRQPSTRSGEVVKLYEEDNILSGIIRTFEDAGKEQIPRLKADWEKVRRELDSMEESVASAQRVSLAVRHEFAKAKMCMQEYQDDLDQIVKKIDTAKRHLTYLREFRRENPSAPDDDAEALAAQKLARLSSEKVKYEVLVNAEETKTYGLQTKMAQTAAGVEQMKDPAHLTKLKQAEAEAKLRYNDAVAFLNSMHLGPAKLGQVTRRGYGLTAEERVGLHLPLYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX50</accession>
    <name>A0AAE0NX50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase family M3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_518574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX50"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3389342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="952" mass="106770" checksum="CACA290C8D392982" modified="2024-05-29" version="1">MTSNFENQASTNYKEAFSLFDKRGTGRVTLDCLGDLLRACGQNPTLSEIHDLEKNVAGEFDFETFQRILNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGIGQLKYILTNLGEKMTEEEVDELLKAVDTTSGQVNYTAAFILASATFSRVRQATILLIFSIFLFSTVAVILASPRVVPRLQSIFSSLKHAHYPKPPAPGVGLTATQPGPALATVTYTSQSSLLTHPSNFSMAKFANPPQPPPLFVGTKESIVADSEAQVKKTRALLDKLVAEIKPAENPKAATFDSVLLPQIEDENEAALSSRIRGFYQHVSPNSELRDASSQAEKIENEFGIECSMREDVFGLVDAVYKDSGLVASKEKDKDRVIDEALAKSAGLADVESARLLERERQGYIKAGLGLPVGEKRDRFKVIKLRLSQISIAFSKNLNEENGGNWFTREELDGVPEDVLDTLNKGTGENEGKLFLTFKYPDLFPTMKYAKNPEVRKKVFIDNENKCNQNVPLFKEAIVLRDEAARLLGYPDHASFRIEDKMAKTTKTVFDFLGDLKSRLIAGGAKELEHLLDLKKKDHEARNLPFDGNYYLWDHRYYDRMMVEQEFNVDENAVAEYFPLTSTVAGMLRIFEELFGLVFIELTPEDRKRISPTGKGEDISWHEDVIIFSVWDDASEGEGFVGYLYLDLHPRAGKYGHAANFGLQPGFLKPDGTRRYPATALVCNFSKPTPKKPSLLKHDEVVTLFHELGHGIHDLTGRTRYARYHGTSTARDFVEAPSQMLENWCWKPAQLKSLSSHYETGKQLPDDLITKVVSTKHVNDALFNLRQLHFGLFDMTIHTPKAHAELEQMDVSKVYNDMRAEISGIKGPEAQGKPSDWGSGQATFGHLMGGYDAGYYGYLSSQVYSTDMFYSVFKDDPMNKANGRRYRHTVLERGGSQDEMLTLEQFLGRKPSTEAFLKDLGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYF1</accession>
    <name>A0AAE0NYF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_519291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041906396" evidence="2">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="34743" checksum="4C46E81A2F41B05F" modified="2024-05-29" version="1">MKLGAVIVIALTQAMGTAALPIIGIPNYPHNDQPDIVPVPRIFGLPIPIPGPPVEPTIQLRDPKVLARKPKGFIVGPDDDDEEEAKKRSLLIHKAKGFIIGPGDDDEEEAKKRSILARKPKGFIIGPDDDDEEEAKKRSVAVRAPKGFIIGPDDDDEEEAKRSVAVVSRAPEGFIIDPDDDDEEEAKRFVAVRAPKGFIVCPDDDDEEEVKRSVEVVTRAPKGFIIGPDDDDEEEAKRSVSILGRRAPKGFIIGPDDDDEEEAKRSVVHGIWHEGENGNPNWYELLHNSKKREVKPKGFIIGPDDDDEEEAKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYG4</accession>
    <name>A0AAE0NYG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_464612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYG4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="10866" checksum="C7417AA62D46A972" modified="2024-05-29" version="1">MSWSAIGAKAFAAISLLHCCRRMLWPLGPLFFFVICPTRACIGLFQSRQPREQAAQLAAVFPPPDCLNLALCTWQECALSLSLWRILLAARGCESSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYN9</accession>
    <name>A0AAE0NYN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_507582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYN9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="242" mass="27519" checksum="095B452858CCDC83" modified="2024-05-29" version="1">MDIYRALHQDYHNLKTESSQRQNPVNITENSIMFGCGDTWRGKGSLYGSTETQGNQTEAGSSTSSRRQSQWPSTSWLRDEKQEEELENGQRTEEERQAEIRAHNRRLFKTRPAFGNFLAQTPDDRRRICLGDSNSKDDDDYEKEGVGAGGEGVEAQPPAAVIAAEYLQTQQQTLLQMEADAQAREKKNDEVRERMFRMRVARQRALRNMVGQQQMMRSTVLRDAAAAVAAASEMEEKKKGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3Y4</accession>
    <name>A0AAE0P3Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3Y4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="316" mass="35522" checksum="7366DAC028E89FFE" modified="2024-05-29" version="1">MLRTLLITAKPRYCFSRLIFNRRYLSLSTASMTSTAGIDETLSEFFAQYSLNDSSDEVTLSAIVQVLADQVQQASKVEDYVWDANHRILKLAGETNPGPQDALIEFLVKLRQTPVTKAGSDEPLVCEGGRVWTDLPMFGWAARDLWNFDIYNKDTKLEELNTFRCQNAFLAQLTALSNLDDPKDPFDYSLYALWTLRTALEDTPPKDASAGRVTGAVKLAEIWIHYAGDALKKLSAKNLSFEGNMGNPGDKYADRDWKGFSEERWAVWMEELKKAKKDDDDAAKKDDDDAAKKDDDDAAKKDDDDAAKKDDDDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P435</accession>
    <name>A0AAE0P435_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_5643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P435"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3392967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="493" mass="52801" checksum="2CC538ECD9D31D77" modified="2024-05-29" version="1">MGVASPNLAKDLSILDTDWSSPLHDFRQARLSLPRLCTPSRMEKQAGPASLPTSIRPFPLSGPAHCRRGRANDCGSLGSNSSIPEVIEDQGSDVSAEDEYATGAALWDSCLQDHSHGAQSIIFIRPQYTALVDTPARGYNTPIGGTASPGQNRHLAVGRTSCQEGRRDQPLGASPESSPRHRRPQMPKPVSYSLFPLGAINGRPSVPPRRSCLPKITPNTVTYQNVSQPSSNTRDCPMSPVRNPAALALDSISARNASTPLLAISLPPVIPEEPSQTSSCEKPLLDLPRPLTATHRPTISKFSSLSNISTRSTSALAQLAQSQAQCGPINTTRRTAELPPLPRCFSAQPSLSPEELSSPPNKSVFEDPDDEESDNTTGGDESSTGFARKLIRGLVLVRSRDGPKGKESSHQRSASDHSEFNIGSSSCCQSPRSGIASPAMSRRPFAFEINEESPELRRGSGRTEGSSKAGASSWLKRNCSSEALSRILGRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P520</accession>
    <name>A0AAE0P520_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_21562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P520"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="314"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="731" mass="77928" checksum="ABB2E2D8EE19C1BC" modified="2024-05-29" version="1">MKATPLIINWHHENNPHPIYSAHFEPHGKGRLATGAGDNNVRIWKVEEDGEDRKVEYLATLQKHTQAVNVVRWAPKGNLLASASDDGNVILWVQSERHNPASNFGSDNLEDKETWRTKHMCRSMGHEIYDLAWSPDATYFIIGSTDNIARIYNAGTGTLVRQIAEHSHYVQGVAWDPLNEYIATQSSDRSVHIYSLKTKDGQYTLNGHDSSNPSMVASHIKADLPPRRISSNSPAPPEMGYRSALAAIDAVPSVATSSPAPSAPGTPTSVALPMNPPSVFSHSRRSSFSSRRSVSPAPSMPLPAVMPMEASPRPIPTSSGMSMKNAALYASETLTSFFRRLTWTPDGSLLITPAGQYETKHQVDGGKPSYEVINTAYIYTRGGINRPPIAHLPGHKKPSVVIRCSPVFYTMRSSPPVTKHITIDTSSAEEPIPALPEPLSKPSPVPSIMEPPPPPVSTDGSSASKSLNLETNVQTPGPKPVFAQNYRMIFAVATQDAVFLHDTQQMTPIAVVSNLHCAAFTDLTWSKDGLTLLITSSDGFCSTLSFSPGELGQVYAGEIGPKGSSGTAASSSQNTPVPTPTALFAPPSPFPNGSHHRHRDSASSITAPSPPHLSAASFVSTRPASPSRSNSASSIATIQSSATLQPGGVVSNPTLISGQVPSIAAAHSGKIIGVPITTPPETPRASATGPVVGTKRDTSESEVDETEKQPKRRRIAPTLVSAGTDGSANNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5C4</accession>
    <name>A0AAE0P5C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_386871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="82"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="309" mass="34497" checksum="4637B8678759150A" modified="2024-05-29" version="1">MAVINRAKVAGAAAAAVVLAFNIPFLTDLPSLRLTSFIGDFLILDYPFTLPFFRSHDGSHVEDPFICDTQHTYRTELVSLDPLIIYIHNLITPVEISSILRTAEPLFAPSQVTKNGRQLHTSDRTSSSAGLPRDDPAVVCVLGRTRNFLGTMLRNDYDEMGPPQLVRYSAGQRFNIHHDWYDTPRVANDGTSRRWNRIASFFAILESNCTGGETHFPFAKGVAPPSPWGEEQWQGGQIQGEMKTESQPLWREHEDGGLAFRPVAGNALFWVNLHANGSGDTRTKHAGLPLLEGKKTAMNIWPRRYQPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5D5</accession>
    <name>A0AAE0P5D5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_26788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5D5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="183"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="327"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="479" mass="53498" checksum="8E9DBF4B4BE9B522" modified="2024-05-29" version="1">MDFNSSSPYPEGVISFLDTDLYKLTMQCAVLKYYKDVTVSYSFTNRTPEKKLSRAAFYWLEEQVRKLGNISLSAEEHQYLKEHCPYLTPSYLEFLQEFRLRPREQVVTKFLPVGENTGAETDIGDLDIKISGTWAETILYEIPLLALTSEAYFKFMDTDWAYDGQEDQAFEKGMRLLEGGCVFSEFGTRRRRDYHTQALVFRGLTKASKEAEKAGLPGKLSGTSNVHLAMRFGIPPVGTVAHEWFMGIAAINGDYKIATEEALSRWVGCFGEGVLGIALTDTFGTPEFLNAFSKPVIITEAAPKTSRKPSIADSFISAVTALPNTHKEKKTYAEIFTGVRQDSGDPKTFVKVMRKFYDEQGIQDKKVIVFSDSLNIERCLEYKQAADEAGFQATFGVGTFFTNDFVHMSTGKKSTPLNIVIKLSSAGGGPAIKISDNIGKNTGDKATVEKVKRELGYIEKEWVDGDETARWGREEGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P623</accession>
    <name>A0AAE0P623_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_532013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P623"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="510"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117321" checksum="E4742525AF75BCE1" modified="2024-05-29" version="1">MASISALMCFESEEDFEERHRRATIIENQHELKDIIAFNRKRIQFRALPISLLAESADSLREVWLIFVDPGDQNCGTQQRFPKEGDRCRLQLVFPETDDLGEYALYDTERIDNPAALLQFHHAEWNRLAAFKVFLSKGEQSQALRETTAQSDMNFRSGSGPKVLMEGGIRVIFKLGTQSSTTEAELNALKFLMSEEASEKQKEAFKYLMAFQPTSHVNLFHHFKHMAKPRANPFGLPKSVASLYTSFDEDQANAYRHFFSKLPCGVGVLPGGPGTGKTQFNLSSICLAQAQDITVGTGWVETRGAKVLYLLDINKPLDDISGRLAKMYTDVGLKKKVVRLYSWHYGNAAGILDFSKGFLDVVRLAKRLGKDSGGFQLPSHRAPTVHELAWDIFQREKFAFKKLSNKLNAVLRNPRASTIDFKKLVVRLYMDVFKQVDTIFTTPVAASKQFSGLFNPDIVFLDESPHMRELSSLIAIAQFSPVCYIFTGDHRQTEPFVSSGEDENKYIAQLQTSMMKRAYASGATMHELLVNHRAYGNLLSAVSKMFYNGKLVSGLPENGKFPLSVQRLCDRYFKPYTKRNPVGTVSRLIVQISDSEEESHGTSWFNLTHIDFVMSMAQKLCKDPEFTNIRGDGHGSILVISPYKEQVMRYQSVIRASELKGIEARTIDTVQGGEADFVFLDFVRKLATPFNNDPSRLAVALSRARQAEVILMDRGLATNRGGKPWLCDVLHECEASGRFCRVKRLEALEMSKSIDIGRDIKKRLVSQIHKMSEEAKARLPDKTVAGDSEEDEGSDFDDNGGDKWLGDFKSLAIGVPYRSGRVSNKPPKDKPYIINGVVMGPLKFVDRDNHSAQNIDDFAQQWPKTQSPPTDSFHNLLHQAFPNGWTKMVTKSDELLCGLYAVIDSMLAQQLALPTPTMDELRWMLQNANAHFLDKTQDSFLLPSNNLTVDQVAAALHDWGIYQDPALHLRLGVVLGGQDPHPHWIVPTASDKEPDLITVWVHNNALDVHGEGLAIGHYSGIKPNAKPGQILWSNRPNGRPFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P626</accession>
    <name>A0AAE0P626_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_498841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P626"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="292"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="976" mass="105297" checksum="6B7AB6DB41A82F73" modified="2024-05-29" version="1">MAYNRTHTHICGFYFFDLQHHTRRYLPQVAVSVHAQIIASTSRTTLTQTFVNPPENASAIPELRYTFPLYDGVSVVGFVCTINGNRVIRGLVKEKEQARQTYNAAVARGETAGLLEQLPDASDVFTTTVGNIPAGATIKVDITYLGELKQDAEVDGIRFTIPTSIAPRYGEYPGELISSAVSSKAGINIVVDAEMPDGSQIKNVQSPSHPISVTVGNTSTGAAKNADMSLQKASATLALGSAELDKDFVVQIVATNTGNPIAVLENHPTIPNQRALMATLVPKFNIPASRPEIVFLCDRSGSMGDGIKIPNLKAALHVFLKSLPIGVKFNICSFGSNHEFLFKKGSQSYDASTLEKATRYVDTFNANFGGTEISRPLEQTFKQRYGDMELEVFLLTDGEIWDQENLFGMMNRYIQESKGAIRVFPLGLGSGVSHSLIEGCARAGNGFAQIVGDNEKMNNKVVRMLKASLTPHVKDYTLEVKYEAESTQGSDDDFEIVEKVMDALVLEVPESEPEGEGSKPAVASKPISLFDASADPDADVEMADASLDKSAGGKYSHVPPVPEPKLLQAPFNIPPLFSFNRTTVYLLLSPETTQKTPKSVILRGTCAHGPLEIEIPVTVLPEKGETIHQLAARKAVGELEEGRGWIYHAKDAKGRLLVEKHQGRFSDMVEREAVRLGVTFQVGGKWCSFVAVENNKEQNETAQSQAENFQQGAMSGIQHSALASVPKASSVKAKSSAPKLAIAHPQKRSFQTRGAVQMSAMSAMLGGPPPGIQQQQLQQQMQYAAIPPPPMDGMSFGSPLPTGGVRRNRAAPPPPAPQAFMAMAAPRALAASRPATKSISPSSTTVFKKSRKASVPDDPLLEGVRDTSIPADPLEALIALQTFTGSWAWTRSLLDVLKLQGSQAEISQKAVSLNLDPVGSLFATALVLAFLETKLAGKKDEWEMLVEKARDWMSAELASAGGPSAEECIEKVKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6D3</accession>
    <name>A0AAE0P6D3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_426162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="5">
        <location>
            <begin position="446"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="658"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1336"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1346" mass="144447" checksum="9D776237E11EBBC5" modified="2024-05-29" version="1">MATNDLGTKASTPSLREVFATVPDLGGGDDAPPPAYGDSLDQLQLSQAGFEAGAAVTDDGRVNISINQKNRRLSELLAPTLRKQLLTESEPLPPPYIPASLGGLPGQVPPPPMNIVIQIVGSRGDVQPFVALGQVLRDTYGHRVRLATHPTFQKFVEENGLEFFSIGGDPAELMAFMVKNPGLMPGIDALKSGEIKKRRQGIEQILMGCWRSCIESGNGLGPPPRQHRPDEPLDDRFILPGNPADKPFVADAIIANPPSFAHIHIAEKLGVPLHMTFTMPWSPTRAFPHPLANIESTNTDDIMTNYLSYALVEMMTWQGLGDVINRFRVGVLDLEPLSLIWAPGLLNRLRVPTTYCWSPALIPKPADWAPEITISGFYFLNLASSYTPEPDLAAFLAAGPPPVYIGFGSIVVDNPNALTRTIFDAVAKTGVRALVSKGWGGLGTDAVGMPDGVFMLGNCPHDWLFQRVSAVVHHGGAGTSAAGIKLGKPTVVVPFFGDQPFWGAMIAKAGAGPTPIPYTKLNADNLSAAILEALRPETQARARDLGASISQEKGADVGGKSFHQFLNIDNLRCTLAPSRVAVWRPRRSKVRLSALAAAVLVKEGILKYSDLKPYRSKEYSTEDQPWDPISAVTSAFVGDIGTLTMAVADFPREIFKAGQKKNSSQAGAPTGPGIAPKEEDNAASDYVTSSTASGSGSIHSSSLPQPQQTQHNSGTNAANVGVSCPTMPASQSSATLLTSPQQTRGSSKSPSQSADGGENPNQGRSQSPFNMETAIGAGKGVGRIVNTGMQMPMNFCMGLARGFRNAPRLYGDETVRPAEKVTSFTSGLKIAGKEFGLGFYDGIAGLVTQPMKGAEQEGGAGLLKGFGKGIGGLILKPASAIWSLPAYTMQGIHAEVRNMFSKSSLNYIITSRVLQGNGDLAASTAAEQMDILMRWQTHKDDLKGLFQLKQKAAAEAAAQQQNPGGAATTASDTRDGPPPKTGWLHTRHLSIDERRKLHAEKEAWKKRQAEQRSTGRLDIPTNPPSSTASSSTPVIDEEEFERSIRAAVQQTSRGDQDEDARVEAAIRASVAEMRRIADHQNNSNSPALTSSYPVEKRSSPATPTNAAATAAAAAALMVPVEDENLTNITDEEYQALVEEAVRQSLSQQKQHEAPGGGYCSSYDDQSGHSISNEKRGHQSQYFNEKGGKEAATAAQTGAVVDDDEDLRKAIEASKLISKHDDHQLRPAKAFTNEEDDDDAQMRRALEESKKEINHVQRQLTEEETVFEYIKRQSLAEEEYRRLRQASGQQSGGDKGKGTEVSPMDEDEDEYDADLKRALAESLRAANGNPGAGGGQHSKDDGVFEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6I9</accession>
    <name>A0AAE0P6I9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_42066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6I9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3394286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="367" mass="40408" checksum="FE2F1EFB5CDAD916" modified="2024-05-29" version="1">MESLPTPPNEEHLKSQSSKRQHSSSKTVKTVHRGSKRATIHAHHPPSPSHDSQSHSGGDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLVCTAGTRKKTEYKQLPRGYAEVLENTQFALIATVHKLYAMVRNQQPWELGEPELNDRGQPVIHNIASKLGCIRPNSDMDLPVHSVFPEDEAGLAELARQLEEQQRETGDHLVAGGSGSSRQETDSGCCSRTDRASSSDLDHSDLEQDYRRSAFRGSNTAVTMSPVSLSYTDFDVSSTAPPSAVDSFPSQSPSHLPAAFASWMSRPTSMGYDSAAPPPFVPNGSYLNMDMLNQGLLESSFGTIKPHILSCPNPEVMMGMGDPMMYSGYDTESLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6Y5</accession>
    <name>A0AAE0P6Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_444589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6Y5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="357"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="57104" checksum="CAB7683C02434019" modified="2024-05-29" version="1">MVSRMPLIGSSRGCRDPRRQAAQRLSVKVPELERSQPPHSSSDMARGIEEKIQSTPESSKEKEMLAPEDNAGSKKGRGLLPVPSRSSSQRIQPSPTTTGLSGATAGDPRDSIGGHSKESKGRPTATPGNSEPGSPAVASHKKKKGPGFLAIFGCCGVPDNANGLDAEPPVPNHKLDKIPARPATASRRTATPSEQPSNSKTQLYEKESTQQPQSSLEPSKNGKRVSGTSTQDQSTVGGDKDAESKQTTLVGPGSSNPVISVEAPHTTNSDSHRANESLAEKDAEGDVPMPDADSTQQKQGPQSLSGSGDEAHSRLPPPPPGPVPAVPNAPVVTSIDTPSVFAPEQPIKYLLPPQAPEFRGKKCLVLDLDETLVHSSFKILHQADFTIPVEIEGNYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHKVVHHRLFRESCYNHQGNYVKDLSQVGRDLKETIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLASSNVQDVSLVLDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7F3</accession>
    <name>A0AAE0P7F3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_517789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7F3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="856" mass="92242" checksum="9C6D02D5B5DF91C7" modified="2024-05-29" version="1">MPSLWKSGSVAGRAKPPHKSIRGTISAPIPIPPALVDDEFPIRTPGSMVASTVLDDEFPMRKPGTGIASTVPPVEPEIVSSHEHQEELKPNVHPQEQADEQDSEEAREVEEETEKEKMQDVELEHELEHPQPVPVAIPAIPVDVPKSTEVQQDIEPEAPLHPPPAPPSGSSATSIRGPVSRTPPQRASPRRGSPPEVSPHRTSSPLRASPPRSSPQRVMTSPLPRRATNPALSAVRYSVASEAPTSQSKDAPQRKKSTLRSALGRLFGRGRKKNNSAIQDSPVPARDSKPLGSSQHRSDPTAFSRVKETSPQRTASLPITEYDRPLRSHSIGPDDIMAIESARDSLQAEAAATVAGARSSISPVGRRRAATTTSRLFLQPRIRTDWGAGLSPRPASSHGRASRLGDSGEPEDPNEIGRAITSDAGHGLRRRSRSLSGLKDFIQPGGRRRSDEIRYWRESYDPGFMSPLSSNAPEDLDGPMDVSAPESPAVDRPPKTPPQPFNFGPITNDMVGMKITQAASIDTRIGDLEGRTHKLERVVDQLCHSVPGFRGPLGATSQGDLASRKGTQPSYAYSTSSPPPIPAIYRTISTDLKEGPPGSSSQRSLETDSHSQISFGEAPTFIGSLHPPSSSAAQSQSLTVTAPPTISLQDRPTSTSTVRGAASLPTMGRETGSGADDQYAMLAAQLETERAARQVLEAQVMKLSERLNTLSTTMFAMVRGPAESRSHERLAPPSIGGSSPLLQPPKTLVVPQQEALKALSVFETDDEEEEEEEREAEGKESPVKIVAESEDGFTEDDFQTPREDQPTFGYGAFGEELRPDDDDDTAADSDDPKRKKAARTLSLSQLTLGKGQRTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8G0</accession>
    <name>A0AAE0P8G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_492178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8G0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041925472" evidence="3">
        <location>
            <begin position="30"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3395240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="653" mass="72310" checksum="B225AF526D0CAC35" modified="2024-05-29" version="1">MSPSQFCSLRGIHIATVALLLACANGVEALNFANCGEKVRGILNGTIVEGLINDKTIWELGYIYTGPVTKLKPSCPRSEWLTLTLEGCQAICETGVDIAEPADALSLTATWVFPLAILFNLPYESHHHRKVWRTLTAVFNWLGSPPAAMTATFWNFSQIRSCHRRSKGQSSRLNDAYYALSCLNQFDLSENLPGPGQRSSDLEEAAGNKFFKTLAYGLGVFPFSAADPFSAADPFSAADPFSAADDLEVSLDIVLTQELLEKLAYELRMHRRRGVMPTLASLAVFLVAFVFSVVLTFSDIATGSAVVYLAIGLFVLWLPILVTFSIVDRNPISSGRTAELLSRWLYNVNAVQSWAELRRQQPERYTLEHIQWWKEGDVANVSFPVGEFLGQGRAMQYCGIVHAVIASIDEAKAKAKADARAKSEAISQEKSSDHQSEAAEGTDPYDTYGKAIVTHLAGRRPWQWFLIAWSAFLIFWTEIMMAVMLAFMTPTVGPGCYSGSCFLFGAASSISWIVLQLRKNPGRFAKGLAFIFNAAALMWLTATIVMQLAGVFNNCWCQSAPVAYPYLGGYMDFGSYDDYRKYFDIVNYWIAASVVGGLVPIIAFVVALIWWLKCQHLWAASERRDEEIREALRASPRRVVDGVAVRVDTGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8K7</accession>
    <name>A0AAE0P8K7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8K7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="23771" checksum="A491228956B500E9" modified="2024-05-29" version="1">MAMRKPSIKAAMAANVGSCLFLYNGLLSISPQLFTEAALQCIPSSSPSSTTAKQQLQPNSSSEMGLAPSKPTQVKQAKPPKKHKKEYRFDLVCTGCENRKTPCPTVADYLPMYLNDSGKEIAFRMVDTKPDKKDINRYELRIALCPLVQQDALTILDRHLKSRRGENINIDLLEAMLERKVDIFGNVIPLPAEGEKGPRPIRFKREFYDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TV78</accession>
    <name>A0AAE0TV78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TV78"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042073991" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16106" checksum="65AC6F83491C79E4" modified="2024-05-29" version="1">MQFRSTVLSAALLAVSATASPSSAHLLAKRCSPARDPDLPHGYYPPAPCWQDFDTACRAYKREGTDYLIDSKHNLTVIYGVSEYCAAEIKEELARTADGRKNYGWVKKYGKLDYLGSGILVVSNMPTTAVTGFQNLPPSMPGYPSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVB8</accession>
    <name>A0AAE0TVB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_195159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVB8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="199" mass="21981" checksum="3280EA7A789F1AEE" modified="2024-05-29" version="1">MYATFTAQIFPIRTLRSAVVSAMRTPDGSPHAFRQHRGFSIHIAIAAKDLCSASKTSISECDTPVPRVPPSFPHQVVRSYPDRAFKDDACVKFCQSQQGCGKVQTFVNGCWSCCDRWASSESFRQWCDSSPGITLREKSAGRCSRGGAFQTNGHIGVLPSPFFVMNAGEVFYLCRFCPCLQLKLAGGCGELREHAQRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW02</accession>
    <name>A0AAE0TW02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_204615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW02"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="74"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="474" mass="53364" checksum="3960DDE4A33313B9" modified="2024-05-29" version="1">MSFDSDGSHASQQIISVTDYIISHDDDHFVWDDSGRELSEAWVQPVTDAGLDPRKHKVFHHSNKEYLKPPSPFVQQGSELGESGTTKVYKVTPPEGYSYKRPLAVKVIICNENTRPPGPDSNVRRLALEEVRNMAAIRHPHIVVYVASFEDYCIQTKQVKQRMGNRRIVVRLDQQVRRHILGIVMYPPAVCNLSVLMGEVFRNPENEAGLLACLHTYFGCLAQAVAYLHRSGVQIRHKDIKPENVVVDDWGLPVLTDFGLSKHFETGQHSEGPTGKTLKYADPEAIHEVQRDERSDIFSLGCVYLEIATVLLGRPAMFAQEQLTGGIGGGASGHDFKYSESLGRLGHYISVLSRIAEEELLHNPDKEPSARAVLSVLPHIQRMMHRDFHQRPYAHELYPWFRPLYDIHETPGLCHSCELERQSNGRGWSSRTSSPTLLRRMNSSAAASPVMRKNSLLSSSQKSQSPTELETTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWF1</accession>
    <name>A0AAE0TWF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_217238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="150" mass="16689" checksum="D9DCC8CB6A70FB7D" modified="2024-05-29" version="1">MERVHPEMVPLHPYRAPLFSAESALLLAHASRCSCVPSPSSLRLKQNHHRQYQPLSFSLVSRSMLIINKRRLAPSVPLRLISHNTPHQRVSHLSKRSVALAFQSRASNPSPPKETSYFPGPFFAPPTLSVEIMVPLPVIDVSSKTQNGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ65</accession>
    <name>A0AAE0TZ65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_432374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ65"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="176"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3384877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="384" mass="42844" checksum="8B68B986E32F8B31" modified="2024-05-29" version="1">MAAPIAAFNTQNATPVVSIVPSPEYLDQLTALSHSVPTLQKAGYVMYPLSRKEINDKKRCIRCGRRCKSRDKKRKERKEQEDGAPAAEDKNQQKAVPTTQGRLAAKQNPAAHRCRFHPGQNVNGRWTCCRRSASGFAPCASEEFHQTQEYGPGEFESRWKFHSTPFDSNVSPITRAAIAIDCEMGIAVDHESELIRLTAIDYFTGTVLLDSLVWPDIQMIHYNTRYSGVTRGNMEQARRDERCLMGIDAARTELLKYVGPSTIVVGHSAYNDLVSLRWIHTAVVDSFLLGQKEKYDQQILDQQARKAIQRVPTMANAVVSPYDVTPTQAGKKPEDGLSLKAMAMRKLGRAIQTGGRRGHDSLEDAIASRDLVHAHILGLTTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ75</accession>
    <name>A0AAE0TZ75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_471587</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ75"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="311"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3384789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="800" mass="90966" checksum="9642214B87E4D70F" modified="2024-05-29" version="1">MEKVEKVAEALKKATIGAEKKPKKEKKGAAATTDGADAGPLELDPPASFLQERIELFDRLFKEQQDHLATKPHDEILITMPDGSVKPGKAYETTPADIAKGISNSLYKRTVVARIDGDREQLWDIERPLERSCKLELLDFNDDQGKFVFWHSSAHILGEACERRFGCSLCIGPPVDNGFYYEMALPGGATVQTSDWAPLENIVSKIVKEKQPFQRLEMSKENLLKMFAYNPYKQHIIKDKIADGTRTTVYRNGPLIDLCRGPHVPDTSRIESFAIMKNSSSYFLGDANNDSLQRIYGVSFPDKKQMAAHKKFLEEAAKRDHRLIGRQQELFFFDESSPGSAMWLPHGMRIHNALSDYIKEQYWQREYDEVMTPNMFNVSLWEQSGHLAHYKDDMFILDVDKEQFGLKPMNCPAHAMMFRHRDRSHKELPLRFADFGVLHRNEASGALSGMTRVRRFQQDDAHIFCREDQIKTEVADLFDFLHTFYGTLGLTFKLKLSTRPEKFMGEIGTWNRAEAKLEEALNEFASAGGVSWEFNHGDGAFYGPKIDVAVLDCLNRQWQCATIQLDFQQPINFSLEYQTAEGVPKEQQHKDAKAAPVAKIEATKPEAAKPEEAKPQEAEAEIEHTHSALCNHGDSKKVRPLFPKKALTPGCARPVMIHRAMAGSLERFTAILCEHFAGKWPFWMSPRQVIVIPVGMGFLNYAKEVAQILKKEKIHVDVDSTGNTLQKKIRNGQLAQYNFCFVVGDDEMKNRKVNIRYRDDTSTQARDVPVSLDEAVEKLRKLKAERGTYNPFPPVKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZD8</accession>
    <name>A0AAE0TZD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_472338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="50750" checksum="0972EC2E18814326" modified="2024-05-29" version="1">MALWKRKITVSDDTVTSAAHLTLQASLIPCFLVTILFFLWGFAYGLLDVLNSHFKKSLDLGYAEAAGLSSAYFGAYFICPPTISGWILRRAGFRVTFMTGLAVFAVGCLLFWPSGVNKSFGGFCGSMFVVGAGLATLETAADPFLSICGPPRYSEIRLNLAQAFQGVGSFVAPLLASRVFFAKTVDNDEGLRNVQWVYLGVAAFDVLLIVLFFFAPMPEITDADMNVQEKEIGAYDPGPFRKQTNLFLAIWSQFCYVGAQVAVANYFIPFCEEAGRDPAQSSDLLAVGQGLYAFNRFLAGGLLTIPMFKPRYMLTVYLGLCFVFIVAAMNTVGTASIAMLILVLCFESLCFATIFTLGLRGLGRHTKMGGSLLVAAISGGMVFPPMTGAVVDARDAHTAMAIPMMGYILALIYPIYVNIWKRDIMDSHRDTKVGLEPLAPGDKTLQLEAQPSRAEREHTEVPGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZI1</accession>
    <name>A0AAE0TZI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_395340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZI1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="455" mass="49618" checksum="49D83B53B4470E75" modified="2024-05-29" version="1">MAPLRLGYTKSRAGCLRCKQRRCDESRPCRACVRHGVECSLVTPSSPSVDGSSSSAQQTGAPSSPRDVSPNPPARLSRRQRTLRPQPTAPSQDDIPIDPALDLSTTPSLSLSDVPTFEIPDDSPPPLAAAPDPFPYLDKFVAGQACDYDATWVSDLELMHHFTTITSESLSKHGGLGVGDLWRTGVPKLAFVHVYLLHQILSIAASHMAYLHPHNGSKHALQASYHQSLAIQGIRAALTNISPENCHALFASSSMLFISTFAASRPRHDGPGGGPTVDDLIDIFLVVKGIMCVLDTSYETIRTGPMAVLFQKTNNGAVSITLDRIEGQLDNYLGRVCELPEDDPTCAVMKTETANLRRSIRNAVEASLTPEYRIIAEWPIATTDAFITLVRQKNQIALALLSYFCVVINATEHGYWFTQGWSRSIIDDISAIMTSPWNQDSAWALGWITAHSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZL2</accession>
    <name>A0AAE0TZL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_449443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZL2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="791" mass="86819" checksum="8FC61F749E8786C8" modified="2024-05-29" version="1">MTPPTRNKAQSLAAAPPPPPEPEPEPEPEPIEEPPPPPPPLPRSVTAGKPLPIVDTPQPENLPNKDYQSVQESGVLAESLARSRAQWIREGIFEKYWSKPTKRKGAVTEDPNNPPKDSMVKLGQVTITVEPHVFEAIMYGVKDSKPAPPAPSPATRPFQPKLLHQLQRQLQHRLQHRLKLKPQCNLPRELQVNKHHILSRHHRLQFNTRIHNLPTSRLLYTTTPIAFQPMPHSPYHHSMPAPNASTTPTYTTPNYSSPNYAPPNYASPNYPPPNYSPSYPSPSYVAPNYVSPAVPPRPVAAPMMPPPSPHSVSTPPAVAVPQKPAQQTPTQTTPTQPTAAQPQTADPIILGLADRATDDAPLRDIMKRVASGEATKEELIYFQSIIDGITQENAQSKTGEAAPSADTLMVDGRSVRYFADEVRVILEIVLRSNPKQTSANLRPPVGSDPLIVMLVKSALDNSRIKNIIQRIAGNTPNFTDAKELQAALEFLLSKAKLAKAKELQQTQSPVSATSPAAAKASGASSAGPAASSPVVALSATHQQQQQQQQQQQHSMPPPPAPPSLRSRGPPPAPVLDLSAVVFEFSGGTGDRYLFPKFSVVENVPVATGHQVIASFFIVRKGSQSEYPMADPELDYYQPLTIRLFAQTGRHLDYLSKVVAPQADVARYMDDIMDNMTRAEYVLIAMRLPRGEGAGKDLEAGSDEKEKEKEKEKEMEQTSGVKGPKQGDVEPNVQNPPPQPGVLWTTTTTKLQRPEIRELPPRSRMYSSKALDNDDQYQSFISTVSRKEPREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZV1</accession>
    <name>A0AAE0TZV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_560205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZV1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="483" mass="53482" checksum="B9A58F064A4E60FA" modified="2024-05-29" version="1">MDPLSITASVAGILSAAVQVTNILGQIKDASESVKAILVEVSHVKIVVTALQKFIDRSLRLDPERAALIQLEDVVTILTQTVLVFSELGAVVKASSSSSSQGSLSRLRDRVAWTWQQTAATRLVGQLQQHKTSLQLLLQIMQCESNMEALQTAASLQDHIEHQLEGDSDLASRLENLDLPPGALELEDLETSEPSSPIDDTGMNMETEGANKSQPPNPLLLQTESQTVQEVDGTPPASFNEVLHASRVYNRVQDREMDAASTILTTRSRAWSILSGISLAQVSIIAVIKLPLYGAELERFWVIASPMAMSSELTVTETLIPTHSNAPRHMEAALTRRLKKELKEMERAIEQGLTRFSAVPVTDDNWLNWQGTILGPGNTPYSGGVFFMSINFPSDYPFKPPRVRCTTRIYHQNIDTSGYIGLDMLEKQWYPILTIVQVLEAICSLLSTPDPSKPLVQEIAQKYTKDRAQHDKTAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZV7</accession>
    <name>A0AAE0TZV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_186082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZV7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="535" mass="59758" checksum="540A248874F76837" modified="2024-05-29" version="1">MDDQQRARVGIMETLDYILGSLLPGNRHPGFGVTEYEVSSVVMETGFQDFQTLLFQDRDFEYTSTSDADQLNFAHAGFRMLDVLASHLKPHDRHTPPPAAAGHPRAEDEADNPETETILEWNYSESYATYEAPIEHDVTTAVAPQRMQKPARKCSQKLVKMSEIMTVMVTLALATPIVSARYKRFLDMFHLTMDSNDVVRPFAGRPFKAFVRLYTNDFELARKQRLPPDVLQLAAAVNSGLFSRSSLLEASVSGAASGRKRADEGSDGDLDNKERRQRRHKRDKKLADAHELMSSWIYTENTVVVPCGLYVWLVILGAAILVGGGLAIGLTIQDRLTGVDPFNITMYAWALAALWLLILKALLVEEWSWSDFLHGRVRCRSVSELRAVTGIHDQLVIAKLLHDERDSILKTRGPFNAVFLSKSEAGFSIDVPLQNKTLLLSGLVMIKVETPLGHALVCLDVRRGTELSIVAHREVGSMRKERLICPSIERLAQPASTKTLGNGGPYRLPQFPLKSGKLEWRKVEGVYNVLDAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZZ0</accession>
    <name>A0AAE0TZZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_501450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042010564" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="802"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="926"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1326" mass="138584" checksum="1F8AC7897F174AFD" modified="2024-05-29" version="1">MRSLAWAVLALLPALVSAVASTDEYTDADPPQSGYLPNHNIDPNALGSYIAQWRYTGNVNEMFHAKPLTWTPPGGSHEYVIYVSNQNIVRVFDGLTGAIVTQRTLRPYFTAADAQCGDIPNMIGITGTPTIDPATDIMYLYSKGYKGDATGGGTINGEYKLYALRLPSLQDVAGFPVSLEGHNADNDKARYFVGGTVLQRPGLVQAGNQIIAGFGGHCDNFNYTGMLVAVSKTSGVGVTAMRAMMAAPGAPSPQALNIQDQGGGKAGIWQSGMAISFDSFTSRLYLATGNGRGEGDNGNGVPASGKVPISALANAVANFGINTGTGAISPQDYFEAYNYENLNGGDNDLGSCGVALLDPATFSGGGVSRIAVAAGKGATVYILNADDLGGFANGPGGTDNVLQQFSFGTNKFFGGVGSYPLEGGYIYFTPGSDALYAYKFGIVGGKPVFTQAGKSAMTFAGNGVPTVTTLNGRAGTGIVWLADVNQGLVAYKAVPEGGVLVPITLGVATGRLQKFQRPVFGNARVYSSGSNKLICVAGGTPPPLPSSSSTSSTSTKPTSTSTSSTSTKPSSTSSTTSSTSSTTTTSSSKSSSSSSSTKSSTSSSSSSSTKTSTSTTSSSSTKSSSSSSSTKSSSSSSSSSSKSSSSSSSTKSSSSSPTTKTSSSSSSTSSSSTKPTSTSTSSSTKSSSSSSTTKPTSTSSSTKSSSSSSTTKPTSTSSSTKSSSSSSSTKSTSSSSSTKSSSSSSSSSTKLSTSSSSTKSSSSSTTFKTLTTSSTKVTTSASATPTVKVPKPILRTFDWDIGWVRAAPDGFARPFVGINGQWPCPPLVANLGDEIKIRVTNSLGNESTAIHFHGLFQENTTYSDGPAMVTQCPIQPGGYFVYQFVINQPGTYWYHAHIGGQYIDGLRGALIVKDVRAPYGIPDQEFAVTLSDLYHKEAPFLVHEYLSAENSDATGGAEPVPDSNLINDAQNVKFNISPGKTYLFRIINVGAVAGQYLEFDQHDMTIVEVDGVYTQPSTVKQLFIGVAQRYSVLVKAKTTTTQNFAIVALMNSKMFDATMIQPGMLTTGGWLVYDSSKPLPAFFNLESRIQPWDDSKLVPHDVEPVLKSPAATIYLTTSFGTNSWGSTRAMFNGVTYLAQKVPTLYTAMTAPKDVVADPLIYGQNSNTFILPFNAVVEVNINNHDNRAHPFHLHGHNFQIVARGDGGANFPGLFSEPATPIKRDVIIVYADSSATIRFVANNPGINLFHCHTEWHVESGLTATFVEAPEELQARDLYIPVSHRSVCDAQGIKRKGNAGGNAKNWRDLSGAVTESDPNYWGALVAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U098</accession>
    <name>A0AAE0U098_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_191941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U098"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="454" mass="47836" checksum="3065904A3E2C969B" modified="2024-05-29" version="1">MSDQTTIITSSTTILVSYTALFGAVSTQPGPPPVVVGTFRNFLPPLPSIPGGAALPPLFSTGALITIIPPVTTTTPSASVPSTLTKTSPTSSTATPTQLTLSDSTGSFLPTTTGGGFTTDPNKNAIHGDSGTNAGLVAGVAIGCLIVGLLLGLAVAWLFLRRKKERPDPHAGQLVDSTETKAVDSRTIAPPVQDASLSLDRFLLDATPDDEIVAELRALGHLIQEHVENNYHLNPLKANAQTLAQSLFQLGFGKRGSLSAETITALALEPRTRHVALQHVISQVLFSSIDVSARSRLSMLPAPIAAFLQSIPPAEKGSSNAEASALALNRWRVLSAFLLHPNRSQRLALSPSEAAVEPQAAQLAAALDTFLAPFVADNEASRFQQNDHLRAVIVECTKLGYLLLSQPTEWQFDHGDRGGGRVAVVCPGLAKASRKDVPPYTPYRLVVAPSVVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U154</accession>
    <name>A0AAE0U154_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_558654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U154"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75471" checksum="2B73D0F18DDCDD77" modified="2024-05-29" version="1">MPMATETRPRPASGVDLDIHNDNSCDASSQRVPSNSSILGDLPLGNIQNIAKGSVDSLALDFNNLHIHNPAKENIYDQQTTKFRARKARPQVELTTFQTPSTELDVDFSSTRAVSGSNASIVSHEDEGTLPTEQPPRSGGPYLAQQPRAARETPRRSLNAAREDMDSSQAGQKKYLFGCNLIHRRTQSGGDATKDARSANIYTILATRVEEKTGSSEPAIIEETDNMSTTTQVLEADTTIIRLAESQTEEPEIQRDSEATLDTEHDEHHDTVLSHSPSPSVHNAAPRIEDSVEALDKLEEELEALNDVARVNRVLSPETGKAHPPAVMQTIADTVAKTPTTLQRTGSTATRRPGTETVRAKRVERMLSVRKSTSMAFDDKVLTAAKPAGPRKSMVARPTSLLPPKAPAKSSKPPTVSTFELPGEAVARRLKEQREARLSRHITPEEAAVVAAAFSPSKPHVKSTKVPTRPTFELPGEAISRRKREEREAKLRAQEEEERKRREFKARPIRNSIAPNSYPRETVASRARQSKVAPQTENATTEDSVATPRVSPAKKRSSMAATSSSTSRASLSGTSTLSRGRGLMVAPVDSHIGRAASTATSTTGSIHGGGSVGKHSTVSSEEAQQQKLRGKEILARDNVYAVDRERERREREATQAQARQAAAIRSRQLSREWAEKHRTKEAVRASAGASTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1S2</accession>
    <name>A0AAE0U1S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_541735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1S2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="60086" checksum="C56A97A30ED57BA3" modified="2024-05-29" version="1">MNQASPAKLPLSLPLLALVFLALWLVAHYTREYLRLAHIPGPALARFSNLPRLWWVYRREAHNVHIAQHRKYAAAPANAGSASAEPGWAPLVRYGPNAVSVGSAAAVDTIYRMRGDPLLKSDFYSVIPPMRKGAILPTIFATQDEALHRVLKRPIASVYSMSNLVSFEPLVDRTIDVFRKELDSRFVATGETCDFGTWLQYFAFDVVGEITFSKRLGFLEGGRDVEGIMAGIWRWFEYVAVVGQMPWIDSIWVKNKLLSRMRPAKWSPMVQFANKREEERRAMSAADKDKNDRDFLSRFVAAMEKDPSIPPWALRAWTSSNIIAGSDTTAIYLRTMFHQLLTHPASMARLRAELDEATAEGRLSASTASWKQSTALPYLSACFKEAGRVHPPFGLHLERVVPPGGLDVCGRRLPPGTVVGMNAWVVHRDPDMFGPDADAWRPERWLEGDETRIKRMEASLLTFGAGHRICLGKHISYLEIFKLVPTLLQGYDIELVDEGKTWTVENRWFVPQSGLNVRLRKREAKEYEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3L2</accession>
    <name>A0AAE0U3L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_537823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3389753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="325" mass="36613" checksum="404702AC17290D88" modified="2024-05-29" version="1">MSAPSKVAYEAVDLVAEKDEEFETLLESALIKGNGSDDVHAHCSCSNTKQRSPFLQPALTITPWLLSIFFGALALLLWSDHRHEASPRLGTYEAGFATDLVPPSKIPLQKVRFRGSPNFSNKGTAFLDPVDKTAPWPENMVLFGPPSPEIDANWDRILDGRYFSISEDEAERAWGDKRFEYVDEMYGGYTAGLEVFHALHCVNALRQKLHPEYYHFDEPHGPFHTEHCLDAIRQTIQCYGSTTLIPLRYRDALHHSYVDSGQEHTCRSFSFLREFLTSRAKGQDGFAERDQSVLNETRHKLAVEWKTERKKGTSGGGHHGGGMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U847</accession>
    <name>A0AAE0U847_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_48289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U847"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="38843" checksum="0163B0A50A6DC185" modified="2024-05-29" version="1">MKGRPVDQLVYEFMFPKPRQSDPQNFHALLNRHLILEVRQEVHSFYGHLDTPEAKYPGLDYTHPTHRIRLGRWQWHRRLFRAFDGLRLTHAEIAGLTKWEGTKWAKERFEREQGITIEDTTAEGFSDWVPPEERPSTQFRRGGSHEIETQREIGDENMGDESDEELESVGVALNERLRERVAMRNVSGDTSMPLDEEWENWLKNAIESGELRQIAQSSGPDNSLTAEDIFPPRMLAAARSGHWDEIPDFLHDMIRQGLESESQDVQRPAAPAPMPPRSSRRPGSSSIQGISPLEFARAEARAIDFAPDPRRTFSDLRLPLGESGSAPQSDVRIPRAAQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8J6</accession>
    <name>A0AAE0U8J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_517857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8J6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="209" mass="22711" checksum="0EFD97E5FDDBD19C" modified="2024-05-29" version="1">MQVRVFLRYANRRPLSGGICEHPSFLAQKKHRLSSPVAQQSSWGIGTLQITLSQSPPAAALSVSPIPHPRLYLFQSATVLIMDICRLPGIGSNKTRLLAVESFVQQPFRAFSRLLCEGILYSVELARGLASTATLATDIFDLSFHMLSVGQRVYARKLIKGGIDLPSLARSGGLLKIFVCIPCSPTATSDQLSMSSLLLALGPLFCPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8W2</accession>
    <name>A0AAE0U8W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_64326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3395122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="610" mass="68092" checksum="7E059857048E5876" modified="2024-05-29" version="1">MNAGKAMRRTEADEQADFEESLKNFSSEAYTDWPNEAGFDGLTEERGPIEIPVIDNIPPWAAGSLYRTGPGIYKVEDTPVGTFHTTHWFDGLVHTHRFDIVADAQGHVSMFYSSRRQSDQMLEYIKEHGDRKFYSFGQRRDPCLGLFAKFMSAWRSATAPQSEKSIENISVAVHPNFPGLEFASGNLLTDKEASLPPIAASGHRGAFPKNIWITTDNALLKQVDPQTLEPIGFATQQTLHPDLKGPLSCAHAQRDPKTGDLYNWNQQFGRETTYRIFRVSAATGKTDIIASIKGPNVKPAYIHSFYLSPSFVILCIPSSHIGWMGIKIAWERNVLDAIEPFSSSKKCRWFVVDRHHGKGVVAEFETDAGFFFHTINAFEERDDKDLSDGTASLFCDVIEYTNLDVMSSLYYDVLMHKNDAEKKFWGNQQRARDAMTHMARYRFRVPFGENATGDVFTGKGSDSVPSVTKLFRIPGPHSGELPTINPNYATKRHRYVYSLPYWGRNTAMDGIVKTDTLTREATFWDIPDGHTPGEAIFVPRPGGTEEDDGVLLSVVLDGHNRTSYLLCLDARTMIETGRAEVGFAVAHGFHGTHITGSADTIPRVGGSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Z9</accession>
    <name>A0AAE0U8Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_462853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="10022" checksum="D8854D7D233B7BCB" modified="2024-05-29" version="1">MAASIDAGLAFLLAVFLGVVIWQWRRGVRHRRRCQQRDGNGNGNGTNNNKNHTGGPMTTDCEKNGAAAAGECGGGGLGIVVHNTTTAATGSTAEGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JWT1</accession>
    <name>A0AAE0JWT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_136191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000029">
        <property type="protein sequence ID" value="KAK3365387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JWT1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3365387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="15360" checksum="FF02118A8D84811F" modified="2024-05-29" version="1">MYHPLSVFSTLVLSSMYCIVRSRRLSDRSPAPEIATRVGRRQKRHPERRSEIPTTWDDGEIRKEKKTGAEPLVKTLLEHHTSLEREASISPSHRATVTSHPATRSPRALPKRLGRPIVTWLHPSPRPRPPARAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JXZ0</accession>
    <name>A0AAE0JXZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_490314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JXZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="173" mass="19221" checksum="9AE05270EC54DF08" modified="2024-05-29" version="1">MSYYFAVIGTQDNPLFEYEFGTSKQGGDGQLRFSDQVRHLNQFVLHSSLDIVEEIQWTNGQLYLKAMDKFFNSYISCFITGGNVKFLLLHQPPGANSSNVIGGVGGIAATTTRSTSIGANPTSPQTEEAVKNFFTEVYDNYVKAIMSPFYKANMEIKSPVFRSRVAAAGRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYB8</accession>
    <name>A0AAE0JYB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_405482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYB8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24684" checksum="7810467CA20BF4BA" modified="2024-05-29" version="1" fragment="single">RFWLTRTAVVDFVFSILIIFISLAQVLSVTSPYRRGFGLLTWAAVLGCLGNFALGTRNWLLTLSLSKNLETVWNAQAIEVQSDIQTAFKCCGYFKLESPVFVTDQICLNTEVAGLMTGCIMDIVPIVDVRLRAIFTAHFGMVGIRFVMVMASLCWIKENKRLKSKSDEEKKVGKVGITQLSPYSKQMEAPSQSPPVNAAVIAKRRNGVIIGQGLFWMVRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K171</accession>
    <name>A0AAE0K171_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_489705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K171"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3367732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="42651" checksum="655B0CFC606483C5" modified="2024-05-29" version="1">MVFDVIVVGAGVWGAASVEAYEKAGRSVIWIDDNDDEHPTAASADIARIIRAEYSDPAYRKLAEESLQSFKTQEPYSKYFHQTGWFLIQDEQQARHGSIPSGTEDVAVEEFRRKFSAANVDDNLFITRTENVGWVEANNLQQALNAEIRVKKRRGTVTDLIFDGRFCRGVRLGTEDILGEAVVLATGWRTNRLLASHNLAQVDYQVVGVPVLGIQLTDEQYMKYRDMPILCQPGRGEILPPTAQRIMRVNNPRSFHLNSSSAAPTSLSPTHICFKENWDFLGKYFPDLVDRPAVISKICWDALTDSQSFCILQVEGTNNVYYVGGGSFHSWKFRPVLPELIAARLGLKGDDNSEELWVLLTQEQSKKHADLIPTRRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1E5</accession>
    <name>A0AAE0K1E5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_529501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1E5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="36570" checksum="67C298F4FB314E2D" modified="2024-05-29" version="1">MSRPVPEIVPDTKLDSDIQPDYTDYFIFGSDTNNDDPTPRNIKERCWRGRQLGSGGYGTVWLEVGTLGSQKGQARAVKGIMHVPMSSRPLASFRNHDIAITLSSRLAGMRQLILFLSPWIFLEHGDLQAFMGRPLPEAGAIRITKQVIESLTFMHENQSTHRDLKPKNILVKSPGPNWRIKNGYMAPETRGIYTIEDMRLGTTQSPTYPFAVDIWAAGTLAVYLIANESPFKSPMDLSAYFFVGTPLKLPLPINAVSNRCEDFILKCLAASARHRPAAKDAIRNIWFQCHDGNTTESTFHSDTESTFNPTEWLAPDVPDDSTGQSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1F7</accession>
    <name>A0AAE0K1F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_514938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="290" mass="33347" checksum="88989140E234F94E" modified="2024-05-29" version="1">MDFGSPQLDFKVQFQERLQNGAGKALLYSTLDMALFSQAKKAIYSLSYVGRRAYDDSWDRKIYDYEAISYTWGRSTEKAAVRINGRRMEVPKNVRDMLLALRLRWQPRYLWINYICVNQADNDEKIHQIQMMRRVYHYASNVLVWLGDAPDAKDTVCLLTEIARLVVQEAAVARNLQILYGDQYIDWRDLLAVIALFMRPETLGLIRRRENADIGVDDIIRLNNATLLFQVKMQVSAGVSRSLAGYLHALRSFVVTDGRDKVFALLGLVENSHHPLILPRYKKDGGGGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K364</accession>
    <name>A0AAE0K364_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_528977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K364"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042141926" evidence="2">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="216" mass="23714" checksum="D0B2A499F690AC85" modified="2024-05-29" version="1">MPLSPSLMLSLGLAALIAPSLGTLIDLDLIPRGVTGAISNPLAPGVYALEGANFQGNQSWAVSYSKEHGRAVWEEQDHHLATAPRNLLEKRQNDKGKPSPDAKWGTSTVRWCPEDPENTLPAGVCRETEHVAELQRVDPFQQDRLGFREVPPFSLDDPTQPVPSSTQGQLLLYTSCGCEGNPAIRLALREYMQCVNTQTFITQARIFSIKHARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K3E0</accession>
    <name>A0AAE0K3E0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_423334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K3E0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="751" mass="84041" checksum="AE4D389A8BBD4F33" modified="2024-05-29" version="1">MSDTQESPSLEDLTPEEANRIIHSHRKVRYGTACWPCRQRKVKCDNRSPCENCVKREHPQLCSYKPNRSATGKTGSFGAEQLPGKKRARSPDEQDSGQSSEPRETISTYEQETAEITRYVGQNSIPALLREQTSSNEPREVSDIRQDMRSLLGLDNTAPFPLMSSRHLDRLTIDIQSELPNDREVMKLFRTYKEIPQPFWGFIIDIDDFENKLMVYLEDRAKNARASTKVTKPVSASWLSTLFAVLAVGSQYHDSPYHIRTRDSQKYIQISFHFLRLGNFLLRPNLDSIQALLMTSFVLLNDMKAEASWALLGLTCRLAQSLGLHRLQLPDTRQAPAPDSNKKEMARRKLWWTCLWHDTLTSLSFDRHVFTVPICSPMTNIPCCPIPLSPTAKTEGWAYLEAMYHLCQIISERLNPDAIAAASYAQILENCEAVEGIRDRLLAQLRNKESCKSAMDRLQHFAIKLHTSFMVSVCCRPALLRGESVRLDSSQKKLLADRCKQNLTETVRMFLAMHQLSVIPTRSWAFTYHGLSSAVLLGILGETKADPEVRQLQGDLISALSATAAKEQTSPQPHIQKSDHDIELSGPLSRALTALKNIYDHGSVIGPGVKREGSISGTGSGTRTPLNIHQLAGLSNGVSMGQDVQSRNSVQPALDPHQNAALAMAEMQQQQNGSALPDFGSGMAFGQPLQQQGVMPDLSGFDPTAYMAPMDLYDSIFWENPDPFNSGVDAMNFDFLPHPPPGQPPQQQFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4C5</accession>
    <name>A0AAE0K4C5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_564116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4C5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF48">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3369816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="570" mass="64022" checksum="8E65B9F97B521645" modified="2024-05-29" version="1">MPWLTLVCRLITRSYCQIELHTRLSCRPEFICRMDGEDRKRHCWECRRRCLVCDFTRPGCKRCSASGTACPGYSDVKPPRLRWLQPGKVKSRKVQKFKPGPKSDEKTETNNNSSSTPTESASTGEVAEGVCYPGTTAIPRRFEPRTEICALAQAVGYFNTCIYQDLIPVQGLGPNSAIYTISPSQLEGGIVFPDYVRLSLVCMTLSHRVNRTRSDHDTYEQSGLLAETFYRYRGIIIRSLNEDINVESKRTSDAVLAGIISLLLADAQQGPSPHWRIHLEGVHRLITLRGGIHFLARLESLEALLLCFVSVAVIGNTTSQATDLVMAPWHFSELDFILSQYGSKLFPPQMCPPLLFAEIIRINYLRHMWATIITTRPKIAETITHSHEEDESELRQEAYGILSRIQTFHPAEWVSLKPPSAKHDWMLLGEIYQSAVAIYCISSLQSLSILPLAEPLRSSCAAHAERLHGFLVEALASPRIKRFMLWPLVMLGMSLEAVYSITKVHGFVAEELVELSRHLGSYAPLTAKGMLERFWASGGGVGMSWDECFDQPYVFATQIAVDISRISPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4Z9</accession>
    <name>A0AAE0K4Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="8">U1 snRNP C</shortName>
            <shortName evidence="8">U1-C</shortName>
            <shortName evidence="8">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_311234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3370233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="274" mass="28031" checksum="FDE5CF1B949AF300" modified="2024-05-29" version="1">MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQRKPRPAYPNYNHNRYLYRQSPPFSLTIITSNPNHLLTNPRCSSLEIGHEKAQSVIDSITSSYAAEGQAHANPMLPQNQPGGGHGGMGGFGGFPGAPGGMSFPPPGGMPPFPGFPGGPPPPFPGMPGAAGLPPPPGASGAPATTIPPPFGIPPPGMIPPPGGRGMPPMPPFPGMPTNGVMPPFPPPGGLPFPPPGAPGAFPFPPPGAGGAPGGFPPMPPFGPPGGGGQGQGGGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K587</accession>
    <name>A0AAE0K587_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-dependent anion channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_485728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K587"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3369895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="702" mass="74328" checksum="166D6BA6216FC2F1" modified="2024-05-29" version="1">MATTPDRDKKRDGVYFDTVYRCSNKIYQFFGISPASTPSSLSRLLSGVGGEGSNRSSGGSGRHTGTTASATHLISPTEVHDGDHDGGHENGHVVPPAAAAGAHTRDNGHVVVPISTAAENGHPVASHAVASRIRKGKAPPSTCSLMVDNGHAIGPTYGIRDDGHAIAPNGHASTPVTGVAWNNMKQQPNGHAFSPVNTPTVPTAAASHVSDAGGHGRQSWMRPEGLVSPRYFPSPRRTWTWSRGGRTGGGSGGGGLGYRFEEENDRRRQQQQQQRKVRKGGRKGVIKALVQDFGPIWFTWPINAGIIGLLLRLLPSRFQFRGLQALSTIAFLVSLSSFVLISSIFLLRLAWFRRRDVREIVGSGVVNAEDAETADAADLGYLACWPTAWLTLVAFAALVAAEENTDHAVYNFRAVGLAAYVAWWVGAAWVVFALIFALAGLFARPRPGLKTGEGRFAPSLALLICGFGLATLALVGGILVLRLGVPSGRREIPVVSLGLAGPVVVFSLFAAGAALLVSLAVYAVLLHELLLVTGWPPPEQTGAVFLCVGPLAQCAAALQFLGDAVNSMFGGISGESVIDGGEGGGDGVTVVPAFGLPLRIVCTLLAMLLAGAAAIWLFLAFVAVAYRAVRRELAWQQSWNGIVLSVAALALATLRFGVELDSGFFQVVTCVLLVFCVVVFLVNLGFTLWYGFRGSMADHKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5A3</accession>
    <name>A0AAE0K5A3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_514508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5A3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="182" mass="20045" checksum="AD55F17CD2F66E4C" modified="2024-05-29" version="1">MPITRLAAGCLAPIQLLSRARICKRMDPISGLALACNIIDIVGLAIKCGRSVVEAYSSADGTAKAVQAVDTGAKASKASSRSLQVAKPSWSICQRWLKLRSRHASVALSRYPQKEQLPVTPGAMATTEVFRILFAIEESRQRTWPIKDDAMNRYELHSVVYLSAYVGHYEFIDWPLLKQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5B3</accession>
    <name>A0AAE0K5B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_486403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="351" mass="39752" checksum="A7258B0318BA1CBE" modified="2024-05-29" version="1">MSRLKSVSLPLHTSYHLERKPVQGYGLLHTGPRKFRVNLSGLVTDIWHLVRHQVELSRPLYEKRRKIVSQISHFWPLVIEQAPPDIDEYIQPSDSSVLLQSLTSLSVSHFEIENGGTGDPRSVAIRWEFSENEHFEDKVIEKKFWYRHSSDGWAGLVSEPIEIKWKKGKDLTGGLLNMVKAVWDEEQAAVGTNGTTKSKKAKKTADDLTPKQKALKKKIENTGLGGQSFFAWFGFIGRAISAEESRIAVEEENEKRRLRKAGAEVPDSNNGAEDDEDNEDDENDLEIFPEGDTLALAITDDLWPGAIKYFTQAQEQDDMSDVDFESQEEDSEDEQPQDASPGERPFKKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5D2</accession>
    <name>A0AAE0K5D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3369937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="25182" checksum="545DDD349FCD2CE6" modified="2024-05-29" version="1">MAAISIPQVLAKSRAAPPPEVISLENVLRNIDFTKQVTEWANWVSDKCVMCQPSVQWAVGKQDIVRSMDWNVFDMSLVRLPPQPTPPIVPLDTKDFKLKAHELKPKDFVEQRLEEFLGLMDKAELSHDTFASPELLMTVISIDDFTNPGHPVIKPMAIECVAQDPKLNDGDEMPGHPDFQKAGADFYLPALRNDQTLGDDVTLLGMAGCEEDDLYYAAADSFQLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5T0</accession>
    <name>A0AAE0K5T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_454108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3369875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32929" checksum="FC0C5392660F675D" modified="2024-05-29" version="1">MPKPVIGSKDDVLVDHYYDLSKATWHSPYDEPHYARMPGDPSQHTVQQINAALEKMPHECIFFPLPIPWHHYQTPVIVAATPDAEPEDVFLAAEVRMLEHLSRFPPHPNLVKYHDCRARKGHITAIQLRRVEGSNPFDHVRSGRPVDKMAILAGLASAVDHLHRVAGIAHNDIQPMNVMMSPDGRTPTLVDLGSADVLGAELIHNRPYTIWGEDPLDLNQKTLLDGPGGLPTSRKSRDLATLKRLAVWIDDPVDLVQPEIHAGSSDSDSPAADSNTCHDETREAGRMKRKLDAEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K973</accession>
    <name>A0AAE0K973_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_284382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K973"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042006284" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="743"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3371965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="976" mass="105925" checksum="12BB137BC3DE0206" modified="2024-05-29" version="1">MLPPQLSALLLLALPSAVRAVFQDEVGHIDYHYELLGVPQQETTFFHRPRRDEKASLLYTLSDVGVLGAVNPKTGVVLWRQLLNGSITEGGGFARAGEGENWVASALGKSVHAWDAVNGRNKFWTDFDGEVKDLEIMEMTENERKDVLVLFDEDKTHSTVLRRLSGDDGRVVWEFKDVTKDIPLQVSNNVEKVFVISLWGTPAAYNLKVTVLDTLTGKRVDELVIGTKGDVHGKEDVMFVGANSAAPIVAWTDAAHKHLRVNVLGTKTRQEFMLPDDTVSIEIHAPHLVQSQPHFLVHSKTATGNRADVYHVDLKTNVITKAYDLPLLAGPGAFSTSSSGANVYFARVTEEELILVSSASHGVLKRWPLKIEAGKGSAVHGVSEVVKKDGPGAEDSFAIRSAIVTNSDEWLLVRNGEVSWTRPEGMTGAVAAAFAEIPESEELAKSLEQEAHSNPLEAYIHRVKRHIHDLQHLPAYLNSIPTRLLSSVLGTDVTSTEGELVRDSFGFHKLAIIATRRGMVYGLDVANSGKILWNTRAFDLNGGRWNVTAAHVNDTSGQIAFRGSNGDFVVLKTDTGEVSYWNPPGPEVLAQSAAIVDHDELGTLSLPVRLDGKIGDLQQPGVVPRNTIVTRNPQGGLNGIVFTADGDVARESIAWEFSLPKGQHIANIATRPSHDVVASIGRVLGDRTVKYKYLNPNTIVVAATDDDASTLRVYLLDTVSGQILSVAKHEGVDAEKPIECAMAENWFVCTFFGQYTFQDDSAQSIKGYQMVVSDLYESDEANDRGPLGDAPNSSSLGPIDNPLGVVLPSVVSKSFILGAPISALQVTQTRQGISSRQVLAYLPGTHGIVGIPRILLEPRRPAGRDPTPAEMEEGLIKYSPAIEFDPKSIVTHERDVIGVQKIITSPAIVESTSLVLAYGIDVFGTRVAPSFLFDILGKGFNKVTLIGTVLAITAGVVGLGPMVRSKQINMRWQAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAW1</accession>
    <name>A0AAE0KAW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAW1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="239" mass="28354" checksum="A117CAE766CCC8A6" modified="2024-05-29" version="1">MDAPPSNITPPTGRWDRARARWDRGPDDAVDIANSLEIYNLKQWGFVIFRCTYKLQEKWDRFIALARKHARKFLEDRERDDLHGSLVWTVIHDRETLEGAGILDTSRRFAEWDENEGKQEREGSKFTDTWNNCPRYTFFLRADENSVESVVDERQANDRRDEETWEQEKNEEGVNEDYSEFFELRKKFYIDQLVGFFLSYHAFQEKEVIGLVTKCKPPSLEFRPATMHGIFESKFLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEX5</accession>
    <name>A0AAE0KEX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_419297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEX5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="830"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3374942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="886" mass="97866" checksum="75D7E4BB6E2B19A5" modified="2024-05-29" version="1">MSEPKMQLEDWLDDLCVRFIINLPKEDLSSVARICFQVEEAQWFYEDFIRPLDPTLPSMTLRTFCLRIFQHCPLLASFSVENHMRAFEEFLTYKTRVPVRGAILLNEDMDSTVLVKGWKKGANWSFPRGKINKDEDDLDCAIREVYEETGFDIKEAGLVPKDDEVKYIQISMREQQIRLYVFRNIPMDTFFQPRTRKEISKIQWYKLSELPAFRKKGSNQAEDMQAASTAANKFYMVAPFLVPLKKWVLQQKKKDSIRAPNHSHLAVQVPFDEPLTEDDLGMQTEPISGPPNTTSSIETLEGATLELQRLLKVQPPTQGLQMSPAAATIPDKGEALMAILQKKDEASFQLPPQAQPGHPQQPQQPHTPFDLTYSNAPEPHTPRHHHPTQRLHVSEYQPPPNFPLPPTIHHQNGPAGYYNQARAPPQAFHQNQQQFYGRNPYMNPGQMPRKEPVLLHPQPLPPRAQQSILTRGIMPTPNIPDASRAPPQTHQIGPNSYAMRNPEPPQFQQQQGGKLPAQLTNHKISLLNAFKTENKQSSENQAPANTSRGDSTTQSQYSSSARANMPAPQAPNAAAKYLPHPIAPAGQLRSETTATQLVASIAASASISKPALPTDPHRSSLLDMFKKPVPAQASSASSDSTVVPGMSKAAASFAPEEEYGNPSAKPRSAAETLAFAASHTNTGGPVRMNPEVNLPYRAVQILSRPKQAEADKGQAPAPMHIQSQSSASTSSGRHDVRDTTHASLPSPRTHSLLYKSETQEKKTALVSHQSPVQTLSSTHSVSSFQLHQPPASNPEQKQKLLSLFGKAQPSPTAFSAAELVKGKDPVMFDQIRSATPRSRLASLASVPGDSGPGSAPTSRRGSQTPISPADRNFLLSYLENVTSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFD5</accession>
    <name>A0AAE0KFD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_482014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFD5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7593" evidence="2">
        <location>
            <begin position="141"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3375157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="485" mass="56691" checksum="4E5D71BF3E61AB35" modified="2024-05-29" version="1">MKEEEERKQREQREQEERKQREEEERKRQEEEKKRLEEEMARKEAEERKRKEEEERRKREEEKKRKEEEERKKREEEERLRREQLEREAAEQARREREEEERREQERKERALKEEMERRRVAREAREAEQRKIRLEQERIRLAKLPPLLRWLDGSPNPKLPDIAEKFSIMQGVRYDCIIHEANGTPDGREQWLLNTQLALLLGEKDLQLSRYTAWTKIPVSLVAKRIIWRLESDRYALTTPSLYELGKQLPGYYGREDPERMSYRVIERLRADAWEKFAAMDMFFVKASDFMYIIPTIQHLQNVRLTIAYRELPENESQLIKSTPAQKWKNDPDANRFYGFAPSNKHFINGDLISEDTPGLCAVSTSPFPEKRVPRRGLVAVTPDDPDYHRLCKDQGLEYLLGDAHSPLLPNGVHSSPTSASSHMMATSVNGLGSPALITPATTNGGGSRHGHDNQPISPSSESGPAQGRPLANGVHETVNGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJV6</accession>
    <name>A0AAE0KJV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_547096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJV6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="445" mass="49440" checksum="468246FF79982DAE" modified="2024-05-29" version="1">MANNPYSPYETPGQEYFFDEKRLPSPPPTPSPRASAFYFGAAQQRPAVRAHFRNPSVNAGFNYSSPRGPSFSPRYTSDGQYATVSFNYSSRRGPSSSPQYNSDGQYATANTKPLRPNHSPSPSNRRSGQRRTDGRSNTSEDSDEDEYIEINGVFYVLTARRSKPSREYYTVNAGATDYHYHAQGVRLSPPQTRKSPEKPSTKRQATEAEAKLRGNPVRYSLKNWDPSEEPIPLLGSVFDADSLGKWIYDWTVYHHGPSTLISDMAGELWLLLLPLAGKLKRADSSKDIESKGSSVDLRADDPTHWRGIKAGTYIYGFLGAVSGFSSVTISARGAAQEASQLIHESLMIMAATFALPFILFLGKWHPGNDRALFYGLQVIMTLVMGFSAKGWLTSTELMFDWMGYVPIFALLSAVLVSLGIRGYRDEKYYSTCPPTSPDEESTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK08</accession>
    <name>A0AAE0KK08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_398256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK08"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042172407" evidence="1">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3377446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="37636" checksum="C5BA93F84AD41F68" modified="2024-05-29" version="1">MLFSLLLVGLTSASSWASQTVEHSGLHQTGANASTFWYENIKHNGISPFITNGKNWIIFRNVKDYGAKGYGTSDDTAAIQKAINTGDGSKLRNMGSYGATGQPAVVYFPAGTYLIKSTIKSAVGTVLMGNPTNRATIKAAASFSGMYVIFGHDQLYSGLTGFYHGIKHLVIDSTSVPGSKSLGLVEWGVSQNNILSNVMFNMPIGATGHSGIVTPGMCSGLILNNLHFVGGAVGIALSATQYHLKSISFKNVATAVKVTSLVQGTGQGLRIDSCNIGIDATSGGLGAFNLIDSSATKTSTVISSASSSNTFGSLMLENVLVDSSVPTVRSISLLKFSQRLTKSKDYQGRWNNRSHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKJ9</accession>
    <name>A0AAE0KKJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_547954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKJ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="42128" checksum="D22F3189916F0977" modified="2024-05-29" version="1">MATTESSLPSSDAKRQDIIPKSNYDWLLDTVIDGGYLPIPVLRMGIRRQFDARAAEIGSTSVAAARDRKMKFIEELRSREMAIATKTANQQHYEVTTPIMAAALGPRMKYSGCLFTNGDETLAQAEINMMRRYIVNGGFKDGMSILDLGCGWGSATLYFAEVFPNSKIVGFSNSKTQKEYIDGKAKEKGLKNIKVLTGDVVTFEFQPEAYDRILTVEMLEHMKNYDLLMAKIAGALKPDGKFYIHIFGHKDTPYHFEEGWMTTHFFTGGTMPSQDLLLYFQKNLVIEKQWWIDGHHYNKTAEAWLSNWRVNKKNVWPHLEETYGKENTATWFNRWTVYYLAIAEMFKYGGGESYGIIHMLFQKRQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1U5</accession>
    <name>A0AAE0N1U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_515449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042105912" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="228" mass="24080" checksum="56962FFA0E709F97" modified="2024-05-29" version="1">MGLTSVLLVAALCFTPVVLAGEAPTTQFQCDKGKEPTTGFSITDDNTLTYHGSSKFFACPATDTEWNVYVSPDFGQAKCVPIALKADGKCGTPPVKTSSCPVLPAPSTVTEKVRETVWSTVTFTSNFTTVTTATLKATETETVKATETETKYKTTTATTTATEIETKYKTLECSSTSSLGWNATTSKHCTKAKCNKTSSTLITSHKCTKCAGATTAPTSATSAEVTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3X8</accession>
    <name>A0AAE0N3X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_77160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="411" mass="47703" checksum="EC448DF5F21EFFD3" modified="2024-05-29" version="1">MCLTKLYYNTYADGAQDMTEKTYTCKEGRMCRSPELKHYDRKLPFNRLGNFGPESQKSVSERQPTPYKFSSGMEPASSRRSKSPSPVSRHESGMYSSRHRDYHDYYDQPRRSHHRSDARDPRERQDRDPSPKIKRSTTMPGYVVIDQDRPPRPTSRDYSRDIPLGPVHLAEEYGRRRSSRDRDRERDLTPPRDKYHTTSSRRHSHSGGADPRDYVIIDDDQERRRQRREQRRRLSTSAYDEASTSAGTSGVTYGSDPTPSRFLPRRAATVLHSGDGSTSNSLGSSPPKAKHLRWDDEVRAKRERQNAEIANRPLPVELHQDPSRVKGILKTSPSDLKGKGREGDDIYQLRQAVKRMDLPRSRDRAAREGDDYDYDRPRSRFTATDDEYGTDRRRRSRAYGGGSDRYRDSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N573</accession>
    <name>A0AAE0N573_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_487336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N573"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="210"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="443" mass="49863" checksum="E32677037FBCE6C3" modified="2024-05-29" version="1">MSTNNSNPSSSTGRFRRLLHTIRGRNPVDDEPHEDDDRPSLPFLTAERPSILTPTPPRQSVVSLGTFALLPPELRREVLLAAFGERTLHIDLRLMHPRLPDRGDGIDEHGGGLAPKGWNYNPDRTTPKAWRWWSCECHSQFPPGSKWERRAVALTGEALKKRWPYHFPSDDTCSRGDPPFCQLWSASSPSPELISPPASLGKAKKRCESGVGAMGWLLSCRQAYAEGIDVLYATNTFFIESRDLMDALFRPRPRLDTDTTPRQHLLLPERLASVKSLVIRWEVVLFGWLPTEEERAHLIAQLRHLGGSFPSLESLVLCFQDGLYNNPRQRPADALDELERVFLKPLADAVRGLPLRGTKEGGVVVEVPSNVFGELGRLGLNVEVRGVEWASSSVFWWKYPIADDKSDEKGGFYYIKQGAMSDLYWDCDGKPQRASRWVSNCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5Z2</accession>
    <name>A0AAE0N5Z2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_563462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5Z2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="30126" checksum="4EC05ED06A95FABE" modified="2024-05-29" version="1">MSETSANSLPQSCNSISLPLTVSDDDQTIDFLEVVATKGAYLITRPNSPLPRAGCVDSAFVGKLQERLEALLPTCTLETARPDLGEAVLGTISPGEAPSVTAPDGAGNKTQPQGEKRQRDAGVAEAVGGSTKTRKIRTTPRPQRPDALNLRWHSTTRQQRTFDRNELGSQPEIFQTNEYLEGFSESHLVDWRTVRRTGRWFQYLSQLLRTKTGSAVLGRHETPVIENGSNFMIPLGSVPDSKLTEALWVLGVDEDDRCHCQDKSRTVDKKHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N742</accession>
    <name>A0AAE0N742_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_514032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N742"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042018059" evidence="2">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="140" mass="14296" checksum="CA6478939FDB9FA9" modified="2024-05-29" version="1">MIFSAAVMPTTLVSTLQLGAAARAAAPTEVPSLVARQARTGAITFYTPGLGSCGKTSSESDLVVAVGAPEFDKNTPNGNPNNNKLCGKQIKVTAGGKSVTVTIVDKCPACSANDLDLSPAAFNKIADPSAGRVQASWQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N954</accession>
    <name>A0AAE0N954_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_277437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N954"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="466" mass="49888" checksum="0F096A9BA76163E6" modified="2024-05-29" version="1">MKSAIRPTRGRPGKVTKLGSTSGRGRPARHPQAQGQIGVGVGLGGVGGVGGVHQALQQQQQQQQHNQLQEQPQHQHLLDPTKSDLASSQHQQQHQQQHHHHQHQDPSIVFDDPRMPSDEYAAAAAVAVMDADMTQDPTQGEPEADGDLDDDQDHDHNHEHEHHHHQDHTVDLSNPASILANGGGGLGSSGPSAGQTLQQDLQQAALAGHHAHQHQQPPAQMQGGHQSMDPSLVKTTEMLAQESGYRGLNVESALAKRLAREPGHRHAQQRRPDQALNLARRSNVEALFAHIAGEPARIPCKNCHKGHGPWTSCVVVDGQMCGSCANCWFNASGARCSFHETRNPQLPQQQHAAILPTGNVVLPTADPTYHFPSTHGVVSSHGSAMGGSVGHAALLSSNPMLQQMVSRALGEVRVADKASRQLILIDITAKQLALQIVEYEETMQSQEHAGGPGSSRQGGMGDDSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBI2</accession>
    <name>A0AAE0NBI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_477537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBI2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="59" mass="7033" checksum="ADD9046CA0E535ED" modified="2024-05-29" version="1">MYSHLSDLKKNNSLNIEEFKECLRAAWRAVPQSLIERLFDTMENRLRAVKKAQGWCTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFX4</accession>
    <name>A0AAE0NFX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_494825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFX4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="60756" checksum="836A91C01AF5556A" modified="2024-05-29" version="1">MDEMVMLADLVGGLNGEIAARWRRVRELTLWRRHSDVQFATEFRNELLLNPISSNPTASHSSFLLLRQWLRACDENHTQCHRQSVKESFWPKRVIYVSDRNKLTLVEEQPQGEDYLVLSHCWGDPGKEDHKRYWTTRVNYQGRLQGFNYDELPKTFQDAVQVTRALQKQYLWIDALCIIQGPNGDWDSEAKNMADIFAGAYCTIAASSARGWGDGFLKPQSNSPDIGVQGTPSTPTCACDFDKDVDKGPLMERAWVLQERVLSRRTIHFTAAHTYCECGAGVLCEQLTKLQPPFGKQYFILDPNFPSRLNNSGFMRTVDFVRFLFKKYSISGLTVETDRDVAIYSLVKRMGDVLATEVRYGIFRCFLGSLLLWRQTHENETQPISYQGRTVPSWSWMAYSGGIDFLSDAKEDLTIPPRADLDFTEGGKALKVKVRRFGENCRMEQKGKEHAIIDGVEKRVGSVWFNVADRFEFEYCVVVGMREDDKREDPEKTYYVLVIGKKDGDGGYKRLGVGMVEVQYVSSDCNDGTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH18</accession>
    <name>A0AAE0NH18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_200805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="16046" checksum="ECB776EB0BA84F17" modified="2024-05-29" version="1">MASSARMLLLRGATTARTTLFSPSSLSRLAIANPIRQYHRTTALSSPYKDDQDRQSLNPRPSEGTKSGSDDEVAQHKDAAFNPDITSPEAEAESVAKDGHSSVLDASGAYQNFSKPPKGSKSDGKKDASEKRGPSSKTGQTKTKKHGSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHP7</accession>
    <name>A0AAE0NHP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_476341</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3381665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="753" mass="81259" checksum="B62C28EF925021C2" modified="2024-05-29" version="1">MFRAAAVGPYDEAINRATDENLTSEDWGAIMEVCDRVSSDQSGAKEAVQSMIKRLAHRNANVQLYTLEVSNALSQNCGKVMHRELSSRAFTDALLKLANDRNTHTQVKTKILERMKEWSDMFKSDPELGIMYDAYYRLKQTNPSLHPPSAPQKTGLTASDRQKEEEELQIALKLSLQEEERKKLPSPAAGPSAGPSSSGAGAAGGSGAQQAAAPVQQAPPGTTAATVSRVRALFDFAPSEPGELEFKKGDVIAVLESVYKDWWRGSLKGKTGIFPLNYVEKLTDPTPDELQREAQMEAEVFAEIKNVEKLLTLLSTSNTAPREEDNEEISKLYHQTLAIRPKLIKLIEKYSQKKDDFTQLNEKFIKARRDYEALLESSMSHPPGPTYHQYAMRPQIPQSYPPPGPNYGTPPPQQQQQQPGPGYGAPPQQQQQQQPPPQQSGPAYGAPTPQPEPQRYYTPAPAQEGSQYPPSSPSPNFHRPNAATPAPFYVAGAQVPSQPAQSAPQNPQQPPPQQQQYGQRPQEQRQPSGGKQPAPIHTSSPPPPTNQYPPYQAPPAGIRPQNTYGNGGAPQELSTSAYDSPIAGPHHTSTPYSPDDPYAAASPLGGPPNAPSMPPPSIPAPLAPGGPEHRAYGQYSAYAPSQPSQPPHQPYGGAGYDARSESPRPPPAPLGQAPPVPQNNTRPTGLPSSDFAPAPLNPTGSAYDARQTLPSRSTYDVGSSSVPQYKAYVPPGPSAGADDGPSAPGDYYRTAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHX6</accession>
    <name>A0AAE0NHX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_524491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHX6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="645" mass="70160" checksum="24EE38824630123A" modified="2024-05-29" version="1">MSSPSSPPRPRQRKIGSRSCDGCKIRKVKCSETPPCSRCLAIGIDCTFHKNQKTRGPRTLRARTLQQIREAAQQEPQQNEPNPPSSAATAAQQNAPDVPETTPQHHSTATSTPEVTIDSLVLRLCIYRIRLFPVWPIVAVEGVIAALHRDSHDVETLALAVAVGAATMAQLKLDRFQDAGLQDTLTATSLEAACQRIRRGIDNLNGLANLNTLRTSFFLHVYHENLEPGGAKSLLYLREAITLAQIMGLHRPSSYLSLDPAEDRLRRRILWLLFVTERGVAMLHKLPVVLRSAENLPPLSNASSAEDEAHILPAFKKLVNLFWIFDQSRAFDILQDAADNNGIGAAGSASLNPEILNALQRRLLQDAPLVMESGSNDIQNADIWVTRQWMQVLLWRATLGHWGARHKVPGPVQIAQEFLDAISQLPSAALEAHGPAIEFKIYEIASAVADSLSTDLDLPMRASANVQPSNILIKLQGILATSRGGNNNLLGLLGARIAQIEVSPHSGTSLGVGLPQGEQRVEEIISDEDPQDWGMDSSVGDLEPASPDRPRSRHPSLSPWLSLVTAAEFEHQSVLCYSGSGETNSTPQSPTEGGGGNTRNSTSWYTQPFDPYAPTDASSLSVPPPAGDALTDVLANQNWFMGPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP68</accession>
    <name>A0AAE0NP68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_179696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP68"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="20436" checksum="89F284868BCF3C51" modified="2024-05-29" version="1">MCRSCHAWRCLGSQPLDPQNEFSRRCLGPLRDSVGELWGFLHTCCLRKAVETLHKWRFWRSGSIFSPACSCQTLACSTWQCNWTTDYGVTCRDLFNGSGSPTQRGSTTDYDLPIIRDPSILKFPVAANWYVYDGPFGTPKRLVLNLVPLTRDDEVIVHLPNLALSSSTVSPLLVIIRWTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPF4</accession>
    <name>A0AAE0NPF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_181182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPF4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3385287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="544" mass="60286" checksum="9DA58BDB6B4E90C4" modified="2024-05-29" version="1">MVGHTETQGRHLVHSHAKELVPGTVDLKAKEGDDTAYGQALYPVPAEDPNDPLQWSNARKTLILVVCSLYSFLSNSSLLGPSVYIGIYAQEFDVSPSTASNLVSYANLAFGFGSLLLVPLYHKIGRRPVMLGSLVLYCVGLIGCSQANSYASLMAFRVIHSFGSSVCEALPVQLVNDIFFLHERGKRLGYYTVCLCFGATGPLYAGYMLAGGHSWRLFFYVEFAFGAALLVLAFFVVEETTYHRQPPADVTRLSEEVARGSDSQSGEKTAEAIVDDTRLTPDIPPRKTFVQTLKFWGIWEKDSEFFMMMARSFTYFLVPHVFWVITTYGIYIGLGALTFNFIFPLKITAPPYNWSATDSGLIAVASFLGYLLAIPFTATSDRLAARLTRKNNGIREAEMRLGVMLPVMLLAPVGLILFGMAAEKDMHWVTYFAGVTITNFSSYFYFTFTLAYAIDSYNANISEMLIAMNLGKQAISFGMGLDLLTWVLDYGYAVMISGVFVGILLANNLALIIFMIWGKRIRTFMAKTWLARVHAASVKEIATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQD2</accession>
    <name>A0AAE0NQD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_187722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="58536" checksum="214478FD13BCCCFE" modified="2024-05-29" version="1">MASFKIAAPDEYLAITGMGIKSVKITKAAWVWPFQRCMRFSVQPHDYSMNLQAMTKEKLQFLLPVVFTVGPDINQRGANAKYGEVRNDAVSNDAHTAAQGLAGAPADDHGREDQGDSLIKYAMLLADSGNNGKGANNHQFLENIVKGIIEGETRVLVSSMTMEEIFTEREEFKRRIFRNIQTELNSFGLIIYNSNVKELKDAPNSIYFESLSRKAHEGATNQARIDVAEAQLRGNVGEAKRKGEQDRELAKINAETAVQKTERDIERAQAEAVLATRKTELNRDVNIAAITANRKTEAQDEDLKREVEIKRAAAEMERLRASDVVKASITREAKQQAADAKAYEIEAEAKANFEKNKQTTDAGAYKIKVDTDAAAYKTKADAEAWSYAAVRNAEANLQKKLKEAEGLAAMAEAYAKLGQAFGGPAGLLQFMMIEKGTYVELAKANATAVHGMQPKISVWNTGPEAGSGGDGVGAIAGAGQSSTATMRNIYQMLPPLMTTINEQTGITLPEWQFGRMAGQMSQLERGEGDAKANGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQR2</accession>
    <name>A0AAE0NQR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Necrosis-inducing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_523315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQR2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042144850" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="173" mass="18613" checksum="1266B058E20E79AA" modified="2024-05-29" version="1">MKTHLTLIILSLTLLILLAEATPTPAIHPGPGWIPLDKRDDQRKECGPANITDRTSLASPLVADCRQLAFNIRDGGSWSVLGSAQKQILQCKSCAFGVTGSSVTGRVDTYYVGNRDVIEMIDRSIGEFKGHVNEKGEGIIGAEGNMPCKAMFSTDTIVNWGIYNTGFVPPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQV0</accession>
    <name>A0AAE0NQV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_560308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQV0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="659" mass="72404" checksum="35C18025B5E981BA" modified="2024-05-29" version="1">MPQLSEPDFTIPAPYGQACVNCSRSKSKCMRRTAGGPCHRCCRRGQESECRPNATTHPSGPRRKAAKKLTSRTTQLEAKLDSLVTLLQSKTAAQRSSNALLLSPDNTIESPNTSHQSPPPPDPIAPSTSRTTTSNTDPDEHSEVSPQEADECLAHFRSKLRYFPIVHVAPDATAAQLQVDRPYLWLAILAVSVQSSSRQLALGGKLRRLAADSILIHNERSFDMLLALLTYLGWPQFQQNNQPFLGMYSHLILGLVHDLGLDKPPLRGDEPHAIACLRSYGMAFRCSTWVTARTMEERRATLAAYVVTSGVSSFIRKIDPLRWTPYMEESLQMLEERKETPNDAVLACLVRLKLIGDEATKPPWPPAPPSEHLRLVQTFQMKALQSRIDDIRRSLPAEMLADQVVQLHLLHTELEVSELVLWMQPSKSTTNSDPQRLHMLTTCVHNIRAWFDIFLQLSPAPYFLVGFSIWVQFIHVLVSLYRLSILDEQNWDRNLVRSTVDVIKMMDEVIQRFECIGSGEADFGVVIGSGSGEGGGDHTDRVQPFSFAVRQIRALKAVWEPVVNNSVSGAMNNNNGQGPGGGGLDEGGSSSAAAAAAAAADPNGAADLSSWMETADSMLLDGLSSDFVEGISGWMSEMFLPPDMGVVPAGVRYDLGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRV3</accession>
    <name>A0AAE0NRV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_447479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRV3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007096">
        <property type="entry name" value="RNA-dir_Rpol_cat_phage"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50522">
        <property type="entry name" value="RDRP_PHAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0693">Viral RNA replication</keyword>
    <feature type="domain" description="RdRp catalytic" evidence="5">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3386539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="399" mass="44493" checksum="F9F1FEE0B580E729" modified="2024-05-29" version="1">MCDGAYCQEHNDLTEKLQDMPMTMKTQSNGLGLPGRMPVTLECRECDFFPRGPDAKKEMAKHLQTKNHRPTEEYWRNSQFRYHREHEHPTAKDDLVRVPGNDEVDEVRRRTSKTRQGNGGDATGTVAFPAFQIHSPGSNFGNESGIEPYILELNSGEWLQPPVTEHQAGPPETKPADVPLADSGYGSAAAPVLSSWRQDADAEIEQYQPDEEKTVCSDATTILPQFVQECIQATCEDIRMKVGRQLNGNDWTVISGDVPDLLKEFAVMIASGDSSDTNRRIMHFVYRRHQEIASQLAGLFEHDDEAITPDSAVQKPGSMSLGDRIAWWDMIPGLSPPETSDPPPDYYSAEDSESEDGGDLHHPELSRYIKIILSSPAYEWLLESLVKKARVGANAEEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSH7</accession>
    <name>A0AAE0NSH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_430722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="383"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1390"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1400"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1437"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3386921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1719" mass="191269" checksum="B63C30ACD200B034" modified="2024-05-29" version="1">MNISQPVSSSLESVEFTLLSEDEIRAVSVRKIENDNTFDTLLNPVPGGLYDPALGSWGDSLCTTCNLNQSQCPGHPGHIELPVPVYHPVFMDQVYRLLRAQCVYCHRFRMPRREIHRYACMLRLLQVGLLHEAQMVDSFADSEFGEEIYDFRLQDVPTVDHDEAEEEGNTVQDNTIRAREAYVRRVLQQHKSTINLGDIRQGKHEGASEMRRALVKQFLADIIKEKRCRTCDGISPVYRKDRYVKIFERDLTDKEKAAMLQAGKKRGDALVMALKEKKKRNEFNLDEGIADIDLSSNEDEEEQPDSEGDGDDLDENGDVVMTDAQSKDKTAADSAKPAKAQRYISSMEVKERLNFLFEKEQDMISLLYNSKPRPRGAKPLTASMFFIQTLLVPPNKYRPEARMGEGQISEAEQNGLYKLILRAASRVGEISREIGQGAKVSSEGRKARDISALYQAWTELQDAVNSLIDRDKNPVRGAAGKRNEEGIKQKLEKKEGLFRKNMMGKRVNFAARSVISPDPNIETNEIGVPPVFAKKLTYPEPVTSHNFKDLQQAVINGIDKWPGAAAIENENGQIVNLRNKSLEDRVALANQLLAPSENNFSGMRNKKVHRHLTNGDVVLMNRQPTLHKPSIMGHRVRVLPGEKTLRMHYANCNTYNADFDGDEMNMHFPQNEVARAEALQLADTDHQYISGTAGKPLRGLIQDHISVSVTLCSKDTFFDRSAYQQLVYSALRPESGHIMGDRIELVTPAVLKPVPRWTGKQVITTILLNIKPPNCGDLWMNGQSSVKGRSWGANSEEGEVKFRDGVLISGILDKSQLGPSSGGFIHAVHEVYGPSSAGKLLSSMGRLLTRYLSMIAFTCGMDDLVMTPKGEKDRKEMLLAVSEIGREVAAKYVSLEEQKPTKSDPLLLERLEEVMRDDKKQENLDHQMTARCHVLSSSITEACLPVGLQKQFPKNHMQSMTTSGAKGSPVNANLISCNLGQQVLEGRRVPLMVSGKSLPCFQPFDTDVRAGGYIRDRFLTGIRPQEYYFHHMAGREGLIDTAVKTSRSGYLQRCLIKGLEGLRVTYDTSVRDSDGTVVQFLFGEDGLDISKQKYLTDFEFLLQNLDSQLAQIQYADPGTQRFFEHKDEIVKRMKSAIKSSNSRRPLDPVTSEVDPAIFGFATSEKFFTQMMDYIKTNKDGLIKDKSRSDNAGLVARKTAEKILAAKYIRSLVEPGEAIGVVAGQSVGEPSTQMTLNTFHLAGHSAKNVTLGIPRLREILMTASANISTPSMTLVLNEELTESDGERFAKSISVLPLSHVTKEAVVRERVGRGIAYPLAKTFEIRLRFFEAKEYNKTYAIEIADVLDTVEKKFLPLLTLMTKKEIKKRGKENNAATPVIGVKSGVVEQVASNGESGRAGGDDDDDDDDEGDDDNTAAKQRANRSEAVSYGPNDEDDDVIQKEQERQADDAEEGEERLDFIDEAYGGSPEPEDNLDGNKTGAAMSRSREARIKSRNDGVARFRCDEVGGEWIEFTLEYDSTIPKILMLNLVQEAAKKSLIQQIYKLGIATFAQEKVKNPRTGENEDANVVHTEGANLRAMQLYGDYINPNKTSTNDIAQVLEVYGVEACRSNIVRELGGVFGSHGIAVDDRHLNLIADYMTRGGGFSPFNRMGLTGNVSPFTKMSYETTVGFLKDAVLDGDWDSLSTPSSRLVVGKLGGVGTGSFDVLTRVPTDHHQALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSI0</accession>
    <name>A0AAE0NSI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_468551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="70"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1388" mass="156643" checksum="94514BFA20BEA223" modified="2024-05-29" version="1" fragment="single">MASAQVAVSAPNAKPHENLKSFRKVLQHSLSLSDTAWSYNIPGFPPPEATNRLGLTKSLIVKTEGLRHQILLQLQPISENRATKQDPLDSFVLVSFANFNARTLRNQSREAVGTQPATAKECTEYAVKMLRAGVTIQGLHYNFYGHSNSQLKSRTCFLFAAPKDVIRAKVAALGDFSKMKTVQKKAKRIGLLFSVAQVAMTIDPSRVEDIPDIESADGSYVFTDGCGLIAPRLAQELSRRVGIKFRDARYTPSVFQIRYRGYKGVVTVDPRMRAEAGTWLKLRKSMKKFSGGDDHSSSVVQYSKPYAFGHLNDEVILLLHSLGISSAILLQKQREHFDFFAQAVQNPILAFRFLTYVNRFDLAEKVVLGSLDEVRDQIHKLVKIEHSKMIKNEDQQRCRILIRQSRILFGVCDAWDVLQEGECHVCITHCDGQARALKNAEVLVTRNPCLHPGDLQKFRVVYKPELAHMVDAIVFSTRGKRPAADLMSGGDLDGDTFFVCWDKELIPSTVSQPAEYPGAKEPVSFNAITDDDRLVYFAKYNNGSLGRVKNLYLDWARAHGPMSPECQELNRLFSTCVDGNQIKVPPRLETAPKPPEDAPPFILDELHDNAASIIKTWQALSRDFKGSEEYSAEAIDILLSRDADDLTISEFELIQLAWRWCKKNDSQFEDVFHLFDFNLLNAEEKAWALSKVPMKVEYLRLVNNALCQSSLLQEHELYDFKLHYPGIGWKRIFSSTEDRLATFLETVAHSFELFHRKLIVYRVDERLTLAIYVPLKIEKSRECRVDGKVRLFAFPHTKGEERSSRLCLPTKINYQLYCDDNVFQLFENHRSNTWVYISRGPSNDSQYRNVVSTGDRRRARQGTIDKGVNVDFRTSVALDKFSKGLQTHIGRVNRNGVMGVEVYVISNRDTKSLRNLDLWLEYIDTQKVVPLFEQNAKGYTIETLKTVSWAEVPPHIHRIVKRDDLITLLTLDSAAQYAEVFTWLLARDQKEVLFRCFEFLLSSMVERVAFGAVPAETVMYQMMASVEQCPVLAVSFSRLDSWESLPEEVLDVVQVLAEGILLKALVLSASVVGQIMVDPFKTILSRINVLSIQAYARLAELIALTVHSPDLALDLLLEGLEKESHRLIPHRPAIIRHAVKNLVGIAIDHVGEAAEQSRTREDLLDLKLVPESEDGYTVVEAEFRIDSRGGTPEKSAHVRLIAASPPSNSLMGRVCSVDALVISSSPGSAKFKCFHPMPEFVERCSWKLQYCGPFVTTKTMFESVLNLALSPESCCEIYGPIMGIRDENTESGLFLEPSEIFYARLGELNESQNAAVFSALRWPLTCLWGPPGTGKTHTIVEIIKQIQRHHKGIRLLVTAPTHNAVDNVMRRYLKDVEQNMASPLRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTC4</accession>
    <name>A0AAE0NTC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_521390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTC4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="32451" checksum="546BE8C40CD1C773" modified="2024-05-29" version="1">MPQALNINIRKAEKADLEALSTLVLTSFSQFSLFAYLYSPLQRDINVASETLWYWRRRLRLGMLDPASHVIVAEATIDSEEDIPTADEDGDEGGQSRRLLDWAMQKTRERDPQFQLQTVDIGDRQTKTYIVGFAIWNVRDPPDGSPKAATGRPPQSWLEWLEAKYIQTEWKFWKTISPRKDQDPEAFPLYLESEEKLEAMCYSTETVYYLDNVTVDFRFQRRGIGKELIGHGLAEATRLGLKAMTEAGEKGEGLYYKLGFEKVADWEVCDMKFPVMRWTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTN2</accession>
    <name>A0AAE0NTN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Origin recognition complex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_521575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTN2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3387523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="411" mass="45651" checksum="ADA429C8C56FD768" modified="2024-05-29" version="1">MNRSIEQALVSLLPTNNATLPQDLTQLASSLLAQSRHRASTLKAEEEVARPYACAHIACARLKISLNLPPIDPRPPIPPRIYKRLYNHLDKILPASSSTPGTPGRATPGAVARTPNSRLRNGSQPHQLGSSPSKSRSRTTPAAKDKTLAEFRRGTGSKPGTPSAAKDSDGLPSWIRPTLRFLCAGLGPARIGPVVMSGVESIVAPRGVRTDDEWVNGNMVAMLGALYLYVWRGVMYSDTDLDAAQYAKFRKELAAALARAREEVKLNAKAPPRKKKQANGEEDGDDDDDERWEGWHSVRPKDFDAAALKMNRYGWLKLDWARGIDDLAQAARDGEEEDDNDDDDGTNQEPVQLRRADTMFQERYDYLSERKKKEYAVWKEGIMGRIKELEGDHRSLARPESDEDAMDIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTR6</accession>
    <name>A0AAE0NTR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_160231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTR6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042162997" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15277" checksum="67DB3A26B32AD189" modified="2024-05-29" version="1">MSLRTISTPPQQRHTILLASVFVLHLVICWTATQHQPTEQRCGESKEKQVYEEGGQRCGGGTASPCVCIEHWRSLVSNYSVSVPSYDILRLVLVRCPRLRNLTLVFFCWWLAGLGFFLLLGRRAVSETGKKGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU18</accession>
    <name>A0AAE0NU18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LicD family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_161772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041945131" evidence="5">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3387620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="298" mass="34461" checksum="074EF8FD530CB830" modified="2024-05-29" version="1">MKLFTFLPLSSLLLVTSFIPSSYALPNPRGADKERLPRFNFNSIISEEKYFIEAGNGIDLGHYDKRYFQGLIDYDEHRATLQHLIRSYLTVFREELNIETWLAHGTLLGWWWNGRIMPWDADLDVQVSAEALSLLTKTGYNMTFHDYQYTSDDDEDGKGRKKQGSRRYLLDINPWSAERSRLLGLNVIDARWIDTSNGMFIDITGLAERDPDNMPGVWSCKNYHRYYTTDLYPLRETEFEGVPALVPYSFNRVLIDEYGTKSMVQTEFAGHHWVPGVKAWLKDLSPDASESVQPMMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUK0</accession>
    <name>A0AAE0NUK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_559388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="205" mass="21829" checksum="6AFF037C98AE1CFE" modified="2024-05-29" version="1">MSSSTIYLVRHAESAHNVSKDFSLRDPGLTELGVTQASALQSTFPALSSVAVVLASPLTRTLETTIAGFGHILSSGDTKLVLDPDLQERSDLPCDTGSPPAALKTKFPALNFSGLKDDWYVKEGAYSADDTAVVARAKAVRQRLADIVQGLEKEETDKKDAVVITHGVFMKFLADDPAIDLPKAGWKAFTLGESAEGDAVLVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUQ0</accession>
    <name>A0AAE0NUQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_448751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUQ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042241740" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="18272" checksum="3B939985AC454075" modified="2024-05-29" version="1">MVNMLTASFFALALAATGLGQTAPEGYRKVYITSLVNTKFVVVPKAAKSGSTIVVQTRTDKPDQHWYIKANSTKIQLASNTSLCLDGGNWKDMGTIYLNTCVETEVGQKWNAMADGRIALEASSPQQCIDLQYMRATQNNPVGFYSCAGLGNTGAADKGINWPLANVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX22</accession>
    <name>A0AAE0NX22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_445368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX22"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="200" mass="22134" checksum="054AFE9C0C72CE54" modified="2024-05-29" version="1">MAPTQPPTDRRPVVISGPSGAGKGTLFNLLFERHPDTFTFSISHTTRKPRQGESHGSHYHFVSRDDFVALKSQGGFVESAEFSGNMYGTSKQTIEEQSAKGKVVVLDIEMEGVKQIKATGFPARFVFVAPPSEEELERRLRGRGTDDEPSILKRLAQAKVELEYAKTPGVHDKIIVNKDIETAYKELEDFVFAPEPAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX34</accession>
    <name>A0AAE0NX34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_507000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX34"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="623" mass="69266" checksum="65C3E4216BC8ADFF" modified="2024-05-29" version="1">MDDTQETSGAGGSGTEPERKARRSHRKSRYGCTKCKERRIKCDELKPKCSRCNKMNLTCQYPKRQPEGVLGSDESWLLIDEQIDPLLLQLDSSARSPVSPDSSCHSSAAAGSPLPSTSNGPSSQSLMLLPAQGRRFDSPLRSPVAQALPPVEYDLFKHYLEHTSKDMTVDEGDQYTLQIGIPNLACQSKPLMRSVLALAAACKCSDIIAQPYVSHQDRSQVIELVSLGHDYHMESLREIQATLTEARQYDNVLANAIMMGMYGSASHSVRIWLVKTASLDDPPLDHLIPRHSQWITFYRAVDLAYIGLLHDTPHVDDTMRLSPSRSLMDPALTGNTNAQMRYEYKVLSRVDLPRTSPISHVLSPILAATVGSALARLREKGSEIAVIVQASEDGVMGNHYQGNHYQGDPNNLPTAHGNSDVQACITALAVFSSVVTATFPVEGSSAATAAAHRNSFAADLESIDPLGRLAEVSPWLRTFTARATFMLPSRVPRRLIVSFIHKVPTRYLSMVEEMLGIIRNQNAPGENDDVEMKWGGSWTSSIRPEPSLAHQLAIDIFAHWLVLVILLDNVWWIGGIGAWELGRIVSIRKDERWANCLWNVDQDWWPESMFEVNRQLEKHRTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXB9</accession>
    <name>A0AAE0NXB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein rds1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_409224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXB9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042031200" description="Stress response protein rds1p" evidence="1">
        <location>
            <begin position="25"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42183" checksum="62469F7BBD587C08" modified="2024-05-29" version="1">MPFITMVSGLCCALWLLTIPGARSAPWSTPAPSEVPKHYSGAAQKLADPNYGPIPGESDIYNSYWGLDRPFPGNIRDPIFPTKVGPPADDDFTWQNLLSAEWLIFEFYQQGIESFNESDFVKAGMPNTTYRRLQEIRNNEAGHLRIFQNQISSTSVKPGPCNYTFPFKEPISYMALMTVLEISSMAFLTGLVQQPKVDFEKGAMLAIAAVETRHEVWALMDIWKSNPFGGPSDTIFPYANEVLDTTNAFIVPGSCPKENPEFPHPRQKLPALSAGKDTLSLTPGSLISLDFTDKKNQPKFDHDKVYYAVFFHGVLNVSVPIDTKDWPQKEIWATIPSSFETKGIIVAAVADKPGAPTKESIVAGPGVILEQPAKLATALLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXI9</accession>
    <name>A0AAE0NXI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_518621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXI9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1231" mass="133437" checksum="5D27E2D441C6077C" modified="2024-05-29" version="1">MTPASSTFYFDFSDTKKQSVANLLKSIIYQLISTYKEISEPAVDLHTKCHGLTEPGLDELLGVAMAEVSRTERTFVLIDALDECSEEERAVFFETFRPPLPGNLNLLITSRKEVDIETALARSASHSIRIRSSCVDTDVRIHVNNSISRDRRLFRWAVCQLDAMKRCLTPAMVRAELKRMPATLYQTYDRILQAVPTLHQPFVQSAIHWLAFSRRPLLIEELSEAAVFDPEAEEFNPEHSRLFDENVILELCGSLVTSSIIDNTYVNWLNVYTPDRRLNEHPIFYGRAMRRGPHNLPQSFYWASFLGDVELVEWLVSLGADVCAVEGNAGSALGAAAYRHNVDAVELLLSFGSDPNLENPELGNVLQVAALGGSAKVVKQLLDAGASVNAQGGSYNTALVAAASKEHYDIAAAAGDLKTAIILLGAGADINDTTYSDGTALYASAQSGSIPLVQLLLRNGAEVNKVGRGEFGYPITAAAAKGHVQIVRMLLRTGADANVMGGHRGVTCLEAAVESRSMESFRVVLEAGADPNIRGHGMTDIAKDLIQRRADPNRYLYMTDESPFTEAVKQACERDKGDLELVKLLMEKDADINIGNGLALYWAATCEGDENENVLRFLAESGADLDLVSTSQKCTALQGAIKEGRKLIADLLLELGATINGPIGGNGYVIHYAIASGDASMVQYVLQKGAFVDDSSTGHCSIWSAVRYKKAQLIPLLKSKGAKIKSVSPAFAMSRWWKDKASYRMLIEEGCTFSGNGATYLIDQIDVEAWDELKEMLSDGIEVNSHTSYQTPALQVALAGRKDVLELLFTYGADINYAPHNIVSCLVGACSNNDISMAEFLLDHGADVNFVVQERVSALSTAVSTVDNLPLVKLLLYHGTEVGLDDGYVFQEAIWGGYKILDQLFQQRMKSSQREVYLNLALQEAAYYTLRDVVDWLLEHGANAAYSGGKYGCALTAAVSDANMYDGAGINNRRLIIDLLIQHGATVNPPTVTIQKQNLNRDLKAFAHPPPLVASLHCRSISLATAFLGAGANPNLQGGELCTALQEAARYLGDMFVPLLSAGADPRAVTDGPFGTALHAAAYAHDVPAIKALVAAGADPSLVAGKYGTAVQAAAKLETVSSGWSAGLESLETLKALVEAGADVHAHGGKYDSALQMAAKSDNVLVVRWLVEEMGADITILGGRFGSVQEAAVRKGAWGVVNYLELVGGKMKWESRYGLDQWKNFKVSWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXP7</accession>
    <name>A0AAE0NXP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_463436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="616" mass="65216" checksum="85314FF9BDAEC534" modified="2024-05-29" version="1">MQSVATVATGISDLTTDLTVDHDDSAMTTASTMTQGGRKAAKPRKAAAGKGRKTKAKKEEVVEILEDEPQELQEPPAPKPARGRKRASGAMEDSVVTNAEAPAAKKRHTRVRGSTNVDNSAAATAPHDVEMDDIPPTQPTAGRKKGKTTRKASQSSVRSQASTASLRGNNDDDIDRQLQADLERPLTDDEDLAADSDSERKNAPPPPPPKGRPKKAATTRKASGQKSRSKAFAMLDPAPAALDEADIEADFKAMEAKAEQQEVPAVAETETSAVPKKGRKAGPQKVSKQTKKVKELPPPPESVDELMDDPVAAPEPSRVAVPEAVQEPEPEAADDPDASTGTVVNKSAGRPSLEKRGRGRPSKKSMSMLSAVEEPEPRRSSGVPVQIEVQLEPLRDPGSFTAVQVTPATIARKPVPAPAPAPAPAMAAPPPAPTPARTEKALPPPPPHSATRLPRPPTTPRKNTTPSASARQAAISPSQSPQSSDAENQPPSSKPAACAIAKRVVLAPIAATPMRGSPSKRNIVASLQSTTPWAPVDLDLVFSPSQLAEKENGVDKLLRKGGELTSPEKRMTVEEWIYHNAGLAEQKLKHDCETMVTAFEKEGTRAIHTLEGLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYE9</accession>
    <name>A0AAE0NYE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_105916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYE9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="296" mass="32890" checksum="2CE05D043C5F49F3" modified="2024-05-29" version="1">MTTTFETVPYFFPSHLEGDAHRLNQQHEAFRLLFSSKLVAHGPQLTPDFAGNVLDIGTGTGIWAAEFAVNYPASRVLGVDLNAPSSNVPPPNCTFAALDAENDDQWDALIPEGTYDLIHTRLLVLHLCDPRALLRRCLRALKPGGRVELQESREPFLFDRQTGAGGEEEKEGEDDTPFIRWSKLRVEGTQRCNRDCAVARHIPGWMREDGFVGVEVDEYKLPVGEWMEEESGDLGRAGRLFGECMSWILEEAVRMPLVDGLGWTEEQVKSVAEEAGRDLGNGKVYVPLAVIVGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYW1</accession>
    <name>A0AAE0NYW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_410215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYW1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="264"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="288"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3390333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="416" mass="45840" checksum="E75EB4256737001E" modified="2024-05-29" version="1">MWPVRRMASTMSASSAALRFDLIAKCSTTRARASVMTLPHGPVNLPLFMPVATQASLKGITPEQLEDTGCRLCLNNTYHLGLKPGQEVLDAVGGAHKLQGWKHNILTDSGGFQMVSLLKLATVTEEGVRFLSPHDGTPMLLTPEHSISLQNSIGSDIIMQLDDVLVTTSPDLARMREAMERSVRWLDRCIAAHKNPHSQNMFCIIQGGLDLDMRRECCREMVARDTPGIAIGGLSGGEAKDDFCRVVAACTEQLPDLKPRYVMGIGYPEDLVVSVALGADMFDCVWPTRTARFGNAITKHGMLNMKREMFAADFGPIEEGCGCACCRPIEEEGAMGITRAFVHHNAAKETVAAHLLTIHNVYYQLNLMREAREAIIEDKYPAFVKEFFARLYPDRQSFPSWAVSALRGVGIDLLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYX0</accession>
    <name>A0AAE0NYX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_110534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYX0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="494" mass="54060" checksum="429DA27ADF7816B1" modified="2024-05-29" version="1">MTTDITSKGGDTATPKYERIRSQPENPFAALIPDQQIAVIPSFTLESGVTLRNVPVAFTTRGTLSPNGDNAMVICHALTGSADVADWWGPLLGGSGRAFDTSRFFVVCMNSLGSPYGTASPVTAKDGDPANERYGPEFPLTTIRDDVRLHKLLLDDLGVRQVAAVVGGSLGGMFVLEWAYLGKDYVRCIVPIATSSRHSAWGISWGEAQRQSIYADPKYDDGYYSFSDPPTTGLGAARMTALLTYRSRNSFEARFGRNIPDPSRRQTIGDRASPSTPSEAHFHIHNDGHKWTRTALSRQNSGTGRVPGQTEAELEGTDSPDPQFHGPQSTSLTGGDVIPSGSTYFSAQSYLRYQGEKFVKRFDSNCYIAMTRKLDTHDVSRDRAATIFEALGMIEQPTLVLGIESDGLFTFAEQEELAEHIKDARLERIDSPEGHDAFLLQFEQVNRYTLQFLREVLPDIMSKDVGGAEAESSVGQLTKSSTFGEAEVDDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZE2</accession>
    <name>A0AAE0NZE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_538707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZE2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="463"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="671"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1182" mass="133656" checksum="975E34714977212F" modified="2024-05-29" version="1">MDRARRRELRELNRRAWDGEKDVFPVAASLDSTLKKNTAFIKRLRTAITSATLNTFLQEIRTVSLSKYLSEIISACYEGLCKLKSPGEVEAGVEIASALHQRFGPIEFTEHLGWLLGKAMATPDKSALKALPTDVREKEEKERLVRQRVLLRVVTELWLVGVLRTLDDVSRPDETTKGAAGKAPELKPRASTKGGGAEPFPLEVLKDLLGHDREHANLPLLVIFVKAFSWDVLGVKTAGSEGRKTVEEDGATTSTANGVEEHDDDITAPSGDAPFTSPELQERFRNVLKRYFEDVKGHLLRDQKAIFNQSRKNAEAYVKSGEVFEDRQANFEKQVKAQERLVANAQAIADIIGADMPDLKDTEDPTSSANGSIGIVKAGEYLRGQGDGSGIWEDEEERRFYENLVDLKGKVPGMLLEDAKKKKSDSDDQVGKKIDTSETAEVAKAVDTTVDEQSTAIANKTVGAQVDALLCRLPDLTNKEAIDQTAIDFCYVNSKASRNRLVKALTDVPKGRGDLLPSWARLVATLGQYMPDIPKGLVEYLDAEFRSLQRRKEKEFLGQVRLGNIRYLAELTKFGIVPEHVVFHCLKVSLDDFSRMNIEIICNLLENCGRYLLRNPETSPRMASFLETLQRKKSVQHIGQSERMLIENAVYYVDPPHRPAIQQKERTPMELFIRKLIYGDLTKRNYSKVLRQIRRLHWEEKEVVAILHKVFSKPGKVKYGNVHLLAILLSALYRYHTEFVIGAIDHVIESISFGLEQNDFKFNQRRVAEVKYLGELYNYRMLEHPVIFDTMYKIMTFGHGGPPVPGRLNPFDLPDDYFRIRLISTVLETCGMFFGKGAAGKKLDFFLSFFQYYIYTKNPLPMDIEFLVQDIFSLTRPQWKLASNLEEASKVFQLAVAQDQKTSGVDKGVEQDDRTIESLSDDENGDDLPLAEDDEESASEDGEAEENEQNPSYYGSESEEEAIVVTRQEEEIDPEDEADFEREYAKMMAESLDSRKFERKQQFDVPLPVRSKNRETAPGAEFTPDTAGSESLGGKMAFSLLTKRGNRQQTRTVELPSDSHFAIAMKTQQQAEKEEQQRIKNLVLNYDLRENEDHDGENDSIPPKANISIHKKSTGHEKANTHHHNRIEPRTGNPRSGQRVRKLQLNDLDWYDKSKQIPSHYKSDPGKTCISHTGSVARGTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZZ0</accession>
    <name>A0AAE0NZZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_557473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZZ0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="502" mass="53919" checksum="9C174F38AD46FF1C" modified="2024-05-29" version="1">MIYGSRRVKNPWYTFWIAVMIFIAAVTFCIVQCVEGALQVYISFKARQQGEKQPIVDNGTYPSYSGTAVQGHPSALLREELTPYGDDKGDIGQDARAESVIADMEPVELYASTAQCSTSPAAAPANKQRHKLALAGGDARLHRRRREEAHPDGHAREFGARVVDIGGVLAAFLGLEDPSLGGPCTSNARGSAEIRPPGKKRQTIGKVAATYTSAVIDTGDGRFVFAIALSDMIDLEHRKRNEGVMPPAAVAMPTKAMVATGVIPLAALTRGMARKQSNVNTTTNATATLHEPELDDQASDRVRDPLATRQLAQRHALNALNVLPEDDETDEPNDDQPPPGTNVAPPPPPAAQAQLGPRDPQPGGIQHLIPAPQPAQPVLSKSPIRTDSVAVGRRTVKAPGWPPNRPGHPDPSRHGPSYHSPAPQAITATVAHRPLTASVVARNTVTLYEEVQRVADGLELLIRKHVARFPSEANRLSQHMCDDLELVKGYGVRLKGVSGHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0C9</accession>
    <name>A0AAE0P0C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_411068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0C9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002118">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="655" mass="72792" checksum="9B461121E315485B" modified="2024-05-29" version="1">MASSSNQNAFQDALEDDSSVISTRGLEAFGRKVTTTASHLIGPLADPSSHPHYQSAMSEVQKQLRRPTLQRSMFSMARTTPTDLVRSRLSSKEIQSRALSYVPEEMLRNIPEEENAFSLFQGFQASFPDFTEDGKKHKRRASRGRKLLEETPTAPDSPHAVHKLKKEKASMMHQLEMLGIRKNLASSEIREIDNKMANLAGMRKIILERLANLEQEEALMEHDVVDVEGRLEDAQELADEAESAAMQTPTKSDDDMVSEREDSQGFMSQSIYEKLPSANSTPTKPKKPRNIRRKSMPILHEHYKPGTMIRSMRAHQDSITAMDFDAPFGMMVSAAMDDSVRVWDLNAGRCIGLLEGHTASVRTLQVEDNFLATGSMDATIKLWDLSKAHYDPQGSQFGKDDEDDGIAFENPNDQPVDPPTDSMSDCPLFTLQAHLDEITALHFRGDVLVSGSADKTLRQWDLEKGRCVQTLDVMWASAQASVLSAGDSTWRQTSRASDASADFVGALQVFDSALACGTADGMVRLWDLRSGQVHRSLVGHTGPVTCLQFDDVHLVTGSLDRSIRIWDLRTGSIYDAYAYDHPITSMMFDTRRIVCAAGEDVVKVYDKVEGRHWDCGAGIAEAEEGKTPAIVERVRIKDGYMVEGRRDGIVAAWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0W1</accession>
    <name>A0AAE0P0W1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_133346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="17604" checksum="DCCD5B40F8FE3411" modified="2024-05-29" version="1">MDPITSLPAADVRTLFAEDAVYSTEDPVIGERVQEMQRNGFPIESIEGLDFCEQNVLDDRRVRHVLEALFPRSGLGIYEVYRTEPNHLYAFMTGLNPELKGVAVGLCSPDLHMVLKAGSNLLPVGGWWASNGLLEMPHGILNNCKPIDVVLEKGGLYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P124</accession>
    <name>A0AAE0P124_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">B0H63DRAFT_429966</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P124"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="222"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAK3391110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="58439" checksum="5A2179180FF77C11" modified="2024-05-29" version="1">MSPTNGDAAVGSDGPRLKGKATPDTLKVGCIALVVKDGQPRRAEILSIKETKSGRQYYCNFDNFNKRLDEWVPVNRIDFDQEVEWPNPEKDKQKEGNKKKAPVVPKKAQPSKKSQKKVGKREQSVASEGQTPHPWTEFVESQPQLNKTTSAITDDAEDKVTASLEVGGTPGIGPDEMEIDEDETPAGLAKKERERASSFSREEEIEKLRTSGSMTQNPAEISRIRNISKVEFGRYVLFPWYFSPYPEVFSQEDCIFICEFCLSYYGDLKSFSRHRQKCTLHHPPGNEIYRDDFVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTTRDEKGCHLIGYFSKEKESTDGYNVACILTLPQYQRKGYGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWCENIVELLLGFSEREEKCTIEGIASALAMTTQDVEHTLQALKMQVYHKGEHKIVVPEKLIQQREKSKLKQKRLIDPERIQWKPPVFTASSRTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3I6</accession>
    <name>A0AAE0P3I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_498314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3392743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="75725" checksum="27880647A0856BC4" modified="2024-05-29" version="1">MAPAIEEINVTYIGILIGSEATENHLTNGDTVEKKNESAPEETNTTYHGIPILNDGAEDHIMNGDSVEKNESVHDEDAKTEKSDHELRDKAPDRKYNHNHEPYFEERDSAEVETPKQKDDWWRLYSFCLVRFCPSNPNKSPTTSLYVNAQTIRQLLVDVIGKYPGNPIDVDDACIHAPYHPLFYYRRELEAEGLKRLERGEDGESLEQLNLLLGWIKSHFEAEIAALNKCIANELKAISYDNLWTLFPPNVIVHCKILDQHRAFRLKEGFYDTQDENPGFVTRVLFVDFDGESLGTRRLELSISKFTGTRELKDLSVVPLALREKTTEIRKELFDRGKQFESYIGQHYLQYNAIALKVEPNGYSRISVNGRVMIDCKTYHRCVADDAFTVTTNNPQNRRAARKGVPKTKFSDEKKEYKKLSDDDFLLTNATVRGFCFAEQAFLEFFVDDLYPIEWNSSCFDNLVLDPSTKKTIQALATTHAEVRDSFDDIVQGKGRGLVCVLHGPPGVGKTLTAECVAEYVKRPLYMVSSGIRIGILFLTTNRVATFDEAFKSHIHIPLRYTNLSLDSRTQIWRNFCKMVPGGVDIDEKGLAKLAELDLNGRQIKNAIKAAESLATFDKVKLDLDQLLQVTKIQAVFEKDLTRRSEIDYTALGGTKKDTDHGHMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P407</accession>
    <name>A0AAE0P407_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B0H63DRAFT_3400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P407"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="107"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK3392922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="502" mass="54428" checksum="E28174392C35ECE3" modified="2024-05-29" version="1">MTKVYSAEEVAKHKSADSCWVVLYGNVYDVTEFLPSHPGGSRIILQLAGRDATEDFDPVHPPGTLEENLKPEAKLGIIDAESLTRLQEKERPQQAAKKGDGGKQAPPPLHTLLNLDEIEAAAKTQVSKKCWAYYFSAGDDLFSKYYNGSVFRSILLRPRVFVDCTTTSTATTLLGHKVGTPLYVSPAAMARLAHPDGEAGIAKGISSFGAMQLISNNASQTPEQIVADATPGAIFGWQLYVQTTRSKSEAMLARINKLPQFKSIVLTLDAPHPGKREHDEKSNLEAQLVVDSASNDKSSDEKRPGGGGVGQQLFWGTAADLTWDTTIPWIRKHTSLPIVLKGIQTHEDAYLTARYARAHPGSIRAIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDTIEVWIDGGIKRGTDVVKALCLGAKAVGVGRAALWGLGAGGWQGVERTFEILQGEIETCLKLLGVKTVAELGPRFINTRMVERDIYDGGAGLDKSGLWTPQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P474</accession>
    <name>A0AAE0P474_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_12609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P474"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="402" mass="43469" checksum="CCB1B509F69C5D31" modified="2024-05-29" version="1">MLSHSSIYAELLSNIRQISLAVSLRSPSDGSTRVAVTADGSDVELRHQGEMQRLALPAKIAHGGAVLPINTQGVSTLTWRLPLDPTSSQQKNTTDGDAAPWSATDLEAGSAVTCRQCGAVVVDRDAIKVWKDLPSENWAEMMEFWHCHKPNEAEHHSHENGKADDRSLAARGYGASSNISAQNGVGFVDLTTLLFSESASASLTFSTSGYEHGSTDRHALAETNASGSQHRGLNVFCSACHTQLGFFNFRAAAVTLLKWQISCKSTSAHTPDISECLAATIISTISRSASSKALITPINDTPIGTNAQANTRNALHIWVMNKDIVYSTSTAERSTPAIKLLYRLVPREQAERMLEVITCDAQEISIPSDALGRVIQSLDESNMLLPGSERLFQQWKVGLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4N7</accession>
    <name>A0AAE0P4N7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_516458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4N7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="93" mass="10740" checksum="12577726262B1B6B" modified="2024-05-29" version="1">MAVMHEVALLRAEVSSLRKANEGLRKRRRAKKTHERDNTQVEVLRKAFALHGITFTLQDTERIVNETWAKGIDELGMKNKLRKGTYGALNLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4X8</accession>
    <name>A0AAE0P4X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_457234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52026" checksum="626FD2E81BDCC367" modified="2024-05-29" version="1">MAPLILHNVPDDELYIGDDGVKRPYAMVFPHQDGASGRTRKPVVETGSFGKSTRRSRSKTGTPARREDPTVAAADKVFSNWINEQSRDAHALPQTTTGTGQQVSASQPGLGTQTLGDPNAPTQARFVKKQEPTEIILRGYRSTQQQYAAVNHYEELAGMICEDYSREPPIESRRYKSELREPAYTRRRALTAEERAKVNKADCGEHWVKVTFESAEAAEAAVASSPQSILGHLVYAEPYHGIPPARDEAIVDVPVVTEIPDVGRGRRRASSRAGGASSASAAFARAMMNPDSFDLIPPNANDRAAPASGGGSSTAFGRAMMNPDGFDWSPPRSEQSSRTADSTTVASGTGSSTTATSGTVTGRKGVAGDRSTPPPLQHTPPANPAATDEFCRAIPTVRKVKLLPMEDALLPAPSYTQRMLNHVPIFRWFSGSMIGNEVPRTDTGEFDWDKASLYWKMIWYLDSIFNLFGGEILNADKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P525</accession>
    <name>A0AAE0P525_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_458198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P525"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3393425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="357" mass="40463" checksum="025CA2641DB874F3" modified="2024-05-29" version="1">MGGYIVDEMDVDTPSKSYTSSTGPQFHLFSNLPAEIQLRIWWHAAEAACLHARVHRVGCVVTGTRPLNDDTLIGRKLGTDDEDTEKIPEPTPTQYENLKFELLPTASLIQSTQSSRALLATCFDARRETIVLQRRLPDIIPLHGGGVIRCDLSKDMIMIEDINATFLMEMRENTFGAEGIFDDLQAIKYLGLDVLGDSETFMEMQSGHPRCEAAFVKFVGSFPHLQHIYLLQSTAALDDVHYGEVAEHKETDHFFLGSATAREWYSTQPLHYYWVEESYDRDLAALTKMQIGFGVALDVPPVMTDLNIDSMTRLQDVQLAILRHYRDFQECGELLRAAKAERHLVTLQEFADFIQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5D7</accession>
    <name>A0AAE0P5D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_458739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5D7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20818" checksum="9DD7F026C4C8E611" modified="2024-05-29" version="1">MLGWYQARLAARPLLTQAVTTSILFGIGDIAAQQLVDRKGIEKHDLARTGRMALYGGVVFGPAAATWFQILSRKVAFKSANTTMLARVACDQGLFAPAFIGVFLGSMAVLEGSSPSEKLSRSYWEALSTNWMIWPFVQMVNFKLVPLQHRLLFVNIISIGWNCYLSYLNSDASETKVLGEKDGVVVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P645</accession>
    <name>A0AAE0P645_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_31580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P645"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="81"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3393980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="509" mass="56519" checksum="94B5564E1325973A" modified="2024-05-29" version="1">MLTLDGPVWFYATMAAVILLLAYLVQLNRLLNMTPEGVRRLSPSRWTQASLVETYKRLEKTPITTQSYAGHIPPKLERRYIITGGSGLVGGYIVLQLLERGQPPESIRIVDFREPNRSDMTSGPPATVEFVKTDISSIESTNLAFAKPWHSSVASLPLTIFHTAAVIVPSDRSKLTYGFCEAINVFGTRNVLNASRLAGADILVSTTSGSISIRPVEFWMTPWNMFSDWPRHYWQVLDEQDFFEPPRRHQGYYSNYAASKAAAERIVCGANSKELRTGSIRAANGIYGNPTDNTVGGPLHMRVQPTWTKHCVQSFVHAINVAVAHLQFEAVLASPNSAALPQAGRPFVITDPNTPITYGDVYFLIQTLSVTPFQTLTLQPLVMLLLSYAIEWYRLLLVRNPWLRMFLPLVSGDIQHLQPALFSICTHLVASNEVAGQPVEMGGLGYTGLLTTEAGMVQEIIEWNREHKNSKENGKTYQSSVSLAVEIQRAALGVKSTRRLNIETDGAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P671</accession>
    <name>A0AAE0P671_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_34328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P671"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113333" checksum="B69B79DE75100793" modified="2024-05-29" version="1">MAYNGGYEGGGPGGRPYPGQGPQRLPPQRQYPPGPGGPQQSNGPPQQYDHYQERYGYGPEDYGNGQDQGYGGQQQYDDMNYQRGLPPTQDYPPQDYYEPEPGPGPGRGGRPPMPGPGGRGGPMRPSLNDGGRGGAYPPRGGAYPPGPGRGYPPQGRGGRLGPGPMERSTTMDSGANRRPPMNGPGPGPISPGEPGFGGGSFPTFPGMPRKTDLAQEQQIVAQMSNMEISGQRPDPRGPNGPPQQRGPMRAPQNGVYGGPGPMGPHRGPPQSYPPQDYPDQRRGPPPGPGYRPPNGYQDDGFGPPGRSMTMPARDPMQNPIFPPRRDSAPQKEAAGRGVPPRPNTAQAVRPPPQRIYPPNNGPPPLPDAYRDPGYDSPPANAQDPGYGGQQRPASLDDFYDYYDARDSYPPQNPPMTQSHAPDFNGMPDQRSRTSMDLQAQPGSQDQPQRGPGRLPEVNRTKSQPDLRNSQTVIFEMAGDIPPLPAPNQFQQQPGPPRGPPEAQQNMQNQYQQQPGPPRGPPDNFQLQRQPSFGQQGPPPPGPEGQQNFQLQRQPTFGQQGQMPPGSGLPPNPAPYRPGAPPTGPQGPANPDALPSHPTPVRPGHMPGSVVNLSDRPPPVRHYSGGSASTTSTTLAGSIGTASSTTLAGSPASGPPPSQQSNAPPPAKPVERPVTVDELEHLRGVIKQDPNDQVSALRLAKRLIEASDVLVPNLPDPKARARSRERYIVDAHKILRKLEKASYPDAMFFMADCMGRGMFSSEPDNAHAFSLYQSAAKLGHAAAAYRTAVCCEIGNDEGGGTRKDPLKAIQWYKRAATLGDTPAMYKVGMILLKGLLGQPRNPREAVSWLKRAAERADTENPHALHELALLYESAQPNDAILRDEAYAFQLFKNAAELGYKFSQFRLGCAYEYGLLGCPIDPRLSIMWYSRAATQEEHQSELALSGWYLTGSEGVLAQSDTEAYLWARKAATAGLAKAEYAMGYFTEVGIGVPSNLEDAKRWYWRAAAQDYPKARERLEDLKRAGKDGPRARERISRSKIGKQQEGECSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6U7</accession>
    <name>A0AAE0P6U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_460654</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6U7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="400"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3394337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="836" mass="89680" checksum="6468695F88C33EB0" modified="2024-05-29" version="1">MHLVPKELDKLAISQLGFVAQRRLARGVRLNHSEATALIANNLQELIRDGNHTVADLMSLGATMLGRRHVLPEVISTLHEIQVEGTFPSGTYLVTVHNPVSTDDGDLARALYGSFLPIPSLDAFPLPEPAAYEATRQPGAVVCVKDVTVALNEGRRRIRLRVTSKGDRPIQVGSHYHFVETNPQLSFDRARAYGFRLDIAAGTSVRFEPGDTKTVGLVEIGGNRVIRGGNSLASGVVDLAQVDEIVARLQQAGFAHAPEPESADLVHEAFRMDRAAYATMFGPTTGDLVRLGATDLWIKVEKDFTFYGDECKFGGGKTLREGMGQATGRSDADTLDMVVTNALIVDWSGIYKADIGVKAGVIVGIGKAGNPDVMDGVTPNMAVGSCTDVVAGEGKIITAGGLDTHIHFICPQQAYESIASGITTMLGGGVGPSAGTNATTCTPGAHYMRQMLQACDTLPLNIGITGKGNDSDPLALREQVNAGACGLKLHEDWGTTPAAIDSCLSVCDEMDVQCLIHTDTLNESGFVESTIAAFKGRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPYTRNTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVILRTWNTAHKNKLQRGTLAEDEGTGADNFRVKRYVSKYTINPALAQGMSHLIGSIEVGKLADLVVWDPAWFGAKPSLIIKSGLISWAQMGDPNASIPTVQPIIARPMFAPLVPETSVLFVSQASVSSGAIASYGLRKRVEPVRGCRTVGKKDMKFNDAMPRMRVDPERYTVEADGVALTAEPSTELPLTQSWFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7L1</accession>
    <name>A0AAE0P7L1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_517879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7L1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="473" mass="47079" checksum="4B7996B3C3CE1EE1" modified="2024-05-29" version="1">MPPPPPPPPPPPPPGFGGPPPPPPPPPGGAALPARPPPAVAQTRGALLSDITKGRALKKAITNDRSAPIVAGTPSGGGPVAPPLGAPAIPSFPKSPGSLAPPVPGLRARSNSDQDDRQQAATSSNSGPPQLGGLFAGGMPKLRKTGGRVDTGASQDSSHLSDPEVPKPPTMFAPRPPPGAAPAIPGRPSLPGASSSPSFHPSIANLRRTANDAPRPMSSASMKGPPPPIGKKPPPPPGSRKPSSSVSSAPPPLPGAAAPPPPFSPPPPPASSAPSLPPAPPPPPPALAPRPPPTPARSQPPPPPPSTSHMGFSQSVLAAQAAIRGSAAVSSSLAAAPPPPPPPPPSNYPPRSAAPSPPHSAPAPPPPPPPSAPPPSLSHTPSTASTWSRSALLDPSSFTLAPNGSGAKTPSPTRNVSNPPPPSLAGGARYVVQDPRWKFIGEDKFPKPRDFVGGPRRYRAGRGSSVPLDLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7L7</accession>
    <name>A0AAE0P7L7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_491957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7L7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="513"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114382" checksum="04FC4B6740D78269" modified="2024-05-29" version="1">MLRSRSQQAYVCWRCLGPSSRKALLPMPMPVPAVLPRRVRSAPTPNMSLAACNWYSASRESSTRQALRLWNAENPPPYKIALEEYASKNAAHILNAGVQSADDLLLELEQSRDASRGPQIYGRDFVDLSSEFNTLQAGDLFEIRSTIWGKSFMAICLGTFNGFDHYYTDGGRWFASKNVDTRFVVRGFISDPVMLKPLIHALPSTSGDPEIMNLLNRTKAGPLRSIGAPLIRKIAAFQLAARQYRQTYGAELATAISKLPADDALLTLSEIAHRLIPSYTKRGKANYPDEILYAVHTALQSDDLRFSPVGQGGRNHVSYLFNVRSPSSRVIYDNVEIMVRNFYEFKPKISPIPQQDNEVVRSNAALFQKFVSEAQEAIDANRSIRTWSPHGMIGINEQKSAVPPSTEFSEPSFRIIKFIEMWAASDAFPRGSPGHALGAAVLRAIDRYEDAPFLDTTTGWTFLQEIGWVTPWDVQSRHSLRLPGIELDRRGGLVVPKDPKPVELAPDLLAPLRQDFAESTIYCIDAESATDIDDGVSIESAGDGEHWIHVHVADPASRIRPSTELADRAARLSQTTYLPGHHERMFSDDVIRDTFSLAPNRPSLVFSTRVSESGDVTGYKITPAVIRNVVYITPENVSAICGEADKLTQVPLDSFEVGTPPMQRTPLNRKMAKAEELSEQQLAELQTLSRLSKVLQQTRLKNGAMPVYMPRPRVEVSLEHVEVETAANGFLSCRGDPYIRISYQDSMGSDMVSSLMQTAGQVAARWCFDRDIPIPYRIQPLAKQNHDALRELTQTVLYPQLLEGKHPPMDQVRTLNMLCGGHDISTSPSIHFTMGMDMYTKATSPLRRYCDLLVHWQIEAALLEEHRRESSLASEKEEVEMATATPPYSLFTKSELENSFPQLRVRERHSKMLDNVNGNTEYILQALVRAWRFGENSEKLPSTFRFTVSEVARKAASGRLNWFGQFAQLSQSHLDCLGTIGDVNVGDVFEVELVDVIVPSRTIFVRALKKIDPRDEVGGGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7T4</accession>
    <name>A0AAE0P7T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta subunit of citrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_50753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="35367" checksum="4ED254299B644A81" modified="2024-05-29" version="1">MSLRSLGRNSSPIVRRALLYVPASSEKMIRKSFNLTCDNVTYDLEDSVTDGNKEHARERLVNILGERNSLAGASQSVGELAVRINPPLTQNGLWDLTSVAKIGCVSTIVVSKVNQASDLAYVAQVAQQARPAQFPPLKLIALIESARGIMELSSICSRTDSLDGLIIGLEDLALDLSVTRTPDLSEFLYARSAIVTAARAFGVQSVIDMVCTDYMNDKVLREECQNGKRMGFNGKQVINPRQIDIVQDMFSPSEVEIEWATRVSIASEKAKRDGRGAWTLDGEMIDAPVEKRAQRLLDLAKQCRISIENLREKWKGQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7W8</accession>
    <name>A0AAE0P7W8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B0H63DRAFT_518079</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042286641" description="chitinase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="134"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK3395013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="517" mass="56698" checksum="8D9CA14E0FA4E877" modified="2024-05-29" version="1">MAFISSIRRVSALCFGGLLLLQIFLIVQPVHAADEDYTCSATKHCSLGCCGSVDPTTGIGTCGMGPDFCGDGCISECDAKSECNPGWGLEWSQAQNCPLNVCCSKFGFCGTSAEFCNGHTVPSPQCPGGKSADKKTIGYYEGWNLGRPCGQMPPEEIPLGWYTHINFAFALVNPTTFHIDDMGPDTAALYSRVTALKQRDPDLEVWIAIGGWSMNDPGPTRTTFSDLAKSTSAQDAFFESLITFMQRHNFDGVDLDWEYPVAPDRGGIQEDFDNYVTLLQRLRARLNLTGKRYGLSITLPAAYWYLRGFNLPELEPHIDWFNIMTYDIHGTWDRTVNAIGPYAYAHTNLTEIQQGLELLWRNNINPERVVLGLGFYGRSFTMKDPGCMHAGCEFTDGAHGGQCTGTPGVLSAAEIVQIIANGATVTLDPVAAVKIVTWNSDQWVSWDDAQTLKMKMDYANLRCLGGTMVWAIDLDDGTLLDALGSNLSRNKKTVLGEIPRYLPDFETPWSALGGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8D4</accession>
    <name>A0AAE0P8D4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_445241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8D4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3395195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="291" mass="32438" checksum="E8FCFFF1EB510505" modified="2024-05-29" version="1">MGLGLALPKAAFFVTGTAAVGPFIAFNINIFQNPRAPIGHDLVTGDLRMFTMSYGYRWRAHRTIMHRLLAPKPTLEFVPSQEFEVKQLLHQLAFENGDDHAGFFYHVRRMSFRLSRRPRTAAAWTRWATLISPGAFIEDDIPPLAQILPKFLQPSRRQAAEYAKIVLRGEMRAWNQIKDEVSAGIAAPSFGRDLAESDFREQGLTDEDATWITGGLVEAGAEITAVVIYNLLLYLAATPAAQTKAHAELERVIGRKGGMDTSDRAFEVQSAFRGPKPFLLQLVPRSEAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVF8</accession>
    <name>A0AAE0TVF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="7">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_415824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="925"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1381"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1476"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1511"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3381069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1549" mass="171167" checksum="EDC59CAF4EB6FE1E" modified="2024-05-29" version="1">MRERKSINDVLYANMPSVDEMKSVTNLDALNATEHDLLAVALGAPARQVMIRAEEIGSATGWKDGYLSAEHGFCPVDYNESPGALSNSPGRIWTDLADRMPGCVARGKVRESIANLTIVEGTEDVIPDRALWAAIVVLGMLCSIYRWEDKHDGSEGVAITATKYKPNCEMGDDLGDELIGIPRSIALPYFQVSRRMGRSIPHLTFVDQSSYNMKIKDPSSTYPYVGRFDNMEMRWPMFGESAETSFLRGCADTSASFQHGPDAIASCQEHVMNRNVEGLLREMIRLKEILERMPNAFHTINTNPNSGENYVSAHRWVRWAKFSAPLGKRCPASSGLQFPPYLVMDAFLGRKNYDSFLGREGLHLRAWLPSNHRAFIASIEYHYRIPEFVKQSGDPRLMGVLDGIVEAYTGERGFMGAHRYKVFGILEVAGKTGRSETNGMSGAPDANTRPWEETHKQFSEAMKERLEPYRGKLSVEPHEMRGTFEECRYKSRVLSRSFVDADPSRSIAMVTLDIQNTGITFQPGDRLAVMPLNSWTECAKVAAALGLADYLDYQVPLSPKWQRFAQHLGSVSRTSTPQLTVKDILRRGHLAPITKDLALKIHDMLRASSNTVLQVLATEEWPIRGSLGDLLQSAVTDTNPHIWDRAFDLISNLSWLSELITVEIPRTYSISNFSQELLPSTVDLSVSRAEYKLCTTFAGNNDVTCAGVGSGFLNPFVSSSDEMIETDEEILIGVSRPLNFQLPFDPATPCAYFAGGSGIAPFRSFWQARLASRNNTAGKDLLYLGVQSREKFCYEEELQEYVEAGLMEVHLAFSRDTRGLVYDQTTNDLVEKEMSPRYIDALIVEQGAAISELVMSKKQGGLGGYLYVCGSVAVFDSVMKGIRKAIYNHCSATMETSDMIISKAFAERRFMLDVFMTPKPLPCNLPTIPLSQLARHTGHRPDGRIWIGVHGGVYDVTEFTPMHPGGTLIIKSNAGVDCSKSFDNLGHTNNSEVSSLLTKYFVGQLTPKPDFPGCPELGGLYNLWAAYLKTTVETLVAHQFEMHEIMGASDDRSSDKFALGAAALWSREHLMNPGLGVRTFYQYQSRLLQTGFAALFGPKLQELVLKLSFTLADASHGSDTRLPDVLGMISRAKTSPDAVATSQEVALVGQYVCDKGSNVRFAERGIFSYAAKSVELDIELLEDIREEACHGMDSFGSVMAMDAENDDQRLLVLSTFLIQTLERMAKRLDVFYSKLAQHKVYQPEIEHNPARTRWSLVRRKIKDGSFFILTTETVLGAAPAYVSAQNKGSDISFDGVMNRIQASIRSAALKMAPAPQTLNAMHIARAAPPVVETNGMTTYENNHAVRAMSTFIDANMRSIRRLSRMPPSSMTFEQIQAAVEQQDGISMRRPPTPPPGKGLAPGQERNTSRGTSLERMMASHTRRILNTRSSAPTISTFGIGSPATSQHHYGIRSPPTPPLDATAALNAMMGKLNVRTKGSSTPPSPAMSAASSTASINGGSMVRGRRAMSVRSVSRNQGPHTHSKQLSTNSLRTLRMGTERPVFKMAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVI5</accession>
    <name>A0AAE0TVI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_450513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVI5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="33048" checksum="2003DB4B7E52B313" modified="2024-05-29" version="1">MADSDNERYHEWSPAEYMKYSNFRTQAAQGLIRRLADQFGEDYLPNVNTVIELGSGPGNSTAELARSCPNARIICVDRSDNMLVAAMEANLGPNVEFVQGDLEHYILEAGADLIFSTNALHWLRKDTRIEILQRMFKSLCPGGVLAVHMPDNVRQPAHDEMRATARITFMEWSDDFHDRELRFFREKLDVDPVGEAFIYHLALKKLEDAPIMSFQHWIDFPQYRFASTRDIVDWMKGAELRPYLDEISNDNIREAYLSEYESRLKAHYPTNTLLSTQKSFVAVREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVK0</accession>
    <name>A0AAE0TVK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_197295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVK0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="483" mass="54884" checksum="31F0A3815A33BCCE" modified="2024-05-29" version="1">MPISRKKACESCRSSKARCNRALPCSRCLERHLECAYERPQPFRYRQGQSLRAITCHVAPEFEELEENDLVDDGVLVSPRLTNWALNTVDMPTPATLDFSLFDSTPLWYETLPPMNPDAPSSVTPVTNAPESDISQEPPSHTQPRQWMKSLASLSMRQSMELTQSLSPETPKSLVLCRRKLANMEQYLTSKILFGQMTSYPIMMINKKGVLPPFIHPQCVLEGKSAQECIARGNGNHTCLSQPLAICASLLHMFFTRTPTSSPFVWQSIYQHQQQLFRESKSYGVQELIELLQTAVIYILIQTLDPESIQVNDTISLIRTTSGIGKRLHGLGGYQGYWIERPNDMSRQEWALRESARRTICLLYGIELVFDVMIGRTTSYCGGYTEVPLPSVRSLWDPVEDSTLWKNRYDADSLADSITGQQPHSIDLTIGDLMTLVPRHGMSTNSQGDHERGLRLVRLEKWCEELDDFGSLMWMAVMMRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVR9</accession>
    <name>A0AAE0TVR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_475013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVR9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="527" mass="59691" checksum="F3543836F8D9A1CC" modified="2024-05-29" version="1">MPKSQDTALQKRCWNCRSRKTACDRAVPACSNCRKRGQECQGYGLKLSWPRINDERRAVTAQEHLILPVRAKTLEFVNASSRDIEIWKGENELEHSEGKQGGKSMSLSLTQSSREFQLPRLYEPYMMGFAELDPFLDTKKFSAVSRIITTACDEMGDLYQLLVRISLGNETPPAIATRHAIAALSYQHLDQPATAYFHQTKALSALQVSINCLTQSADSTVAFQAMAASMLINIFETLIFDASSSSNSWDMFFSGAKKIANLIHRPDMTYDGDPALILDWIFYHDTLYKFSIRHWAKREEDQVMLAAQEKIVSKAVFSPMRQLILTSAGCSLELLCLMCQVTDAVLDRDDPRHLTPEHLGMIRNLELRLGRIQQIPRVVPYNPDHDEAIYGPQGTFASRLAELYRLASYIYLERMARCLPRSDEKVSSLVDQAMYILRGLGFCERPWPLFVVALEARNDEERMIVLNVLARSKNKKPLGNIPLVKRLIHSAWVQQDLQAGEEGNNEADPMLVYNTVVSGNRFPPSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW79</accession>
    <name>A0AAE0TW79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bud-site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_546318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW79"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="278"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="509" mass="56142" checksum="29E98FF7ABC92C83" modified="2024-05-29" version="1">MPKRKREEDNVQEIFQKLRTELHHALKSAKGFERQRQSKRLRDAKSTPDKKRRIESEILVLKSLDLQQTAHAHICSSLLRIKSIAESPKLPVEIKAGVAKPELTEEEKVALHNVTSGLYNHKDVRAVIDQAIKQICKALGVPLTEKKGKGGMKPAADDGKKGKEAEPVLVSVEKEDDDAKASSKKEKKAKTIKDPKLVLAEIQDLSDGEPENEEEAEKAIRQLDDLLGSSSDEEDPSRIALVKRSKPRRQAAPKELDPMEITDDEYGGVGDELDPMEITDDEGAEETDSADEEDDEFEGFSDSGLDAKDDDDSSSGDDSDSEDNSEDSEDDSDAESSSSSPSDAIPRPAKKAKATKKKAQAQPDSATTGSMFLPSLMMHGYVSGSESASDLDEKPRKNRRGQRARQAIWEKKFKTEAKHLKNQAANAARDSGWDSKRGAVDGENKPWKRGIRNPLLGSGRADAVPAPRKEVVKKRDDEGPLHPSWEAKRKAKALQKDTAPFEGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW97</accession>
    <name>A0AAE0TW97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_214348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW97"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3381831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="510" mass="56697" checksum="C10E0042E39EE049" modified="2024-05-29" version="1">MLPPVPVLADYGISPTHGFLPEVLPLTRLPDPYYNKWEAIVANLPALILSKRLRGVVDRLPVLSTIGLEHDAEWRRAYSLLSFMAHGYIWGGDSPSDRLPPSITVPLLKVSQHLEVPPVATYAALCLWNFKPLFMDEDIDNLENLATLNTFTGSIDESWFYLVSVAMEARGAPIMQLGLTAIAAARQNDAATVTRCLGTFAERVDDLTTLLQRMHESCDPTIFYNRIRPFLAGSKNMAEAGLPNGVVYEDGSGTETYRQYAGGSNAQSSLIQFFDIVLGVEHRPTGEKRGRPDQQEPREGRPPAPKHNFLMEMRRYMPGPHARFLGDVQAVANIREFVEANRDHRPLCIAYDACLSMLRNLRDKHIAIVTRYIVVPSREVRARSRSRSPEVVRRKLDLATASRQPQGIAYDARGIAQKQQQDDKKNSNLKGTGGTALMSFLKQARDETGEPAVDEWTRRFMSRQGRIEGQGDFFAGKTEGGVGLPTEEVEVAGLAGTWTIDDDVGGICNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWF3</accession>
    <name>A0AAE0TWF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_216888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="78"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2170"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2254" mass="242448" checksum="13B732BFA11E163F" modified="2024-05-29" version="1">MAPIALTPESSTASSSSENLNGYFHVPNGGGATNGHSNGAANGFSNGSNGNGVRLNGTSNGHANGNGATGAFSSSHKIEPIAIVGMACRMPGNVSTPAEFWELCTRARTGWTEIPKERFNSSRFHHPNPGKGGGLNPVGGNFLNVDLAAFDAPFFGLTEKEAISMDPQQRLLLECTFEALENAGIPKHTIVGKDVGVFVGGSFPEYESHLFRDSDTIPMHQATGCAYAMQSNRISHFFDLRGPSFTSDTACSSSMVAIHLACQSLRTGESTAALVGGCHLNMLPEFWVSFSTCRLLSDTGRSFSFDNRGTGFGRGEGCGMIVLKPLSQAIKDNDPIRAVIAGTGLNQDGKTPGITMPNGAAQEDLMRKVYANAGLDPNACGFVEAHGTGTRVGDPIEATAIHNVLGLDRSLRDPLWIGSVKSNIGHLEGASGIAGVIKAALMLERGFILPNYDFKQPNPKIPWKAWNLKVPVTQRPWPRGKKYISVNNFGFGGTNGHVVLEAAPFRGQKAAVAGDDTPDGKAGQGRKLYVLTANDKTALSQLMKNIVIYLEQRPEIFQMDLTSNMAYTLGQRRSLLQWRVAIPAANSFELIEAINGEKATPGKEIEPLRLGFIFTGQGAQWHAMGRELFEQYPTFNKSISNADKYLSKIGAEWSLIEELSRDTKTSKISEAHISQPSCTAIQLALVDLLTTWGIRPTAVAGHSSGEIAAAYAAGIIDFESAVAIAYHRGRLIPILKQKHPELRGRMMAVGGSKEEFLPIIEGLAEKEARIACYNSPSSLTISGDEPAIAELEKACEEKQLFNRRLVVDVAYHSHHMNLVAKEYRASIADLQPPVPTDVRFHSSLHGTLVDGTELQSNYWVDNLTCAVRFSEALQSMLEPVGEHKHGVNMLVELGPHSGLQGPIKQVLKEVGGAAPKIPYASALIRKRDAVETAMELAGSLFTKGANLDFGAINFPKSTKPPVLLTDLPRYPWNYSSKYWQESRMTQMHKNAAGSRNDIIGTLANYSNDLEPTWRNIVRLDDLPWLQHHKIQSLTVFPMSGFISMAIEAAAQRAAAKDSQFDKFELKNVSVTKPLVVPDKDVEMTITLRTLKEDTHSSSDNWDEFRICSWSQGQGWTEHCVGLVATNVSDTNDVDSARQAQDSAALVESTFSAIEKAGAAKIVSENMYETLAEAGVAYGPTFQGVNNCQACDTHAVGDIIAQDIAKEMPNGYLSDAVIQPAFLESLIEMYWPILGAGRQAVDTIYLPSSVDHISISSRITQLTKEPGSILRAVCRGTFAPGIPKPTKVHMTAVAGEDALETLISLDGLMVSPILDGDAQVQLNAPRELCYRLEWDSAPDVQDTQVNLAADTKIVIIHEDSNFQSLVAMDLANALEQITGGLPEVGTLQTVDASGKICVFLNELHQPFLATLTPEQFSALQKLLTSVQGVLWAVRGAYDKSANPDANMITGLSRTIRSETAIKFATLDLDAETSLSEADTTNAILRVFKTAFGSDSSATSELEFMERAGSFFTPRIVGDSEMNEYVHKQTNPSAIEPTPFGDDGRALKMEMSTPGAGDSIHFVDDPTVEEPLEPDQIEIEVNAIGVNFRDTMVAKGQIPIGDSGIEASGVVTAVGAGVSAFQAGDRVAALTQGAFATRTRTKAAFAFKIPTEVSFEASATLPLAYTTAYYSLIEVGRLSEGETVLIHLAASAVGQAAVSLAHMVGAEVFVTAASADEKELLRNEYGIPADHIFYSRSTSFGDAIRRATDGQGVDVILNSLTGEGLRESWSCLNKFGRFIEIGRRDQTKTRLEISNANSNATFTSVDLLALIAERPKVIKRLVADLSRLLKYGKIRPVTPVASFSISEVDAALKTEQTSKTIGKVVVLLNATDIVKAAPSKKVKHLLRADATYILVGGTGGLGRSMARWMAAKGAKNIVLVSRSGSVTGKVKELVDELAAVDVNVVVRPCNVVNKADVDELINSGLQGLPPVRGVVHGTMVLRDVLFEKMTWEDYTQVIEGKVQGGWNFHNALASSPLDFFVAISSAAGAVGNRGQAAYSAANCFLNALVQHRISKGLPASSLDLTAVSDSGYLAEDLEKAAEVARNLGSDSICEAEVLALLCAAIDGTMASTCNSHTITGMRITATLRPFWTEDAKFKAMRIAAEEAAAKDASLNAVISFNAALKSAKSRAEAEEVVCKGLVDKISSVLMLDAEDMDVTRSLSHYPLDSLVAIEIRNFITREFEANLQVLELLSSGSIQTLAKGVCSKSKIVSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZ15</accession>
    <name>A0AAE0TZ15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_559599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZ15"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3384878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="384" mass="38524" checksum="90127640F6B841AC" modified="2024-05-29" version="1">MSGPNIFVSNGTCYTAPGKELDKSFIPCGNAAFGHKTCCGGGDNCLADGSCFGVHGSGYGSYLTYMAGCTDSEYKDASCPNKHIDQPWVALTLCKANDGVWAVCSQIGNPSTLQPGASCSCTSAATATVAFTDANVLTSSCSLPQSTGQSIQFFTGHIPTSPPPPAATTAPGASPSTGSSPGSATAPPQTGSPPSSSGPAAGTTAPPTSGGSIPISSSPQQSGTSSPSSNDNNNNNNNSSDPSSGGLSSSAKAGIIGGVVGGVILLAALAVLFFLRRRRQRPSGSASGKLETGASGGKKQKKHQQRFSDISTPTNASEADGQAVSEADGKAARPWSMRSELEGSQVSSNMSEHQQRLSSSSGGDAHGWRPRKSGELSPVAELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC2</accession>
    <name>A0AAE0TZC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_501250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41007" checksum="588C7CD209D31460" modified="2024-05-29" version="1">MRPAAIDATEPCAPGLVLQIHRHISPDTYGFGDTYRESPRPKVNWGDDESFSMGAEQFACKYPPIETDPPNPDTHTFTINSNKTIRRRFSSSNGGGGAHVVAGFYDGDKSRACLAKIYDGVSYPRRDPDEEVHDCMTLADIDCFIEARAYGVMDPAPEVAGKLVPKYFGSWTFLVIARLDRRGATRTRWVRMILLELVPGESVRDKIDKATIDGKLQYDLLPDELTRLRVLQNTIEAEIAIWWHAQIGHQDLAPRNVIVKDGNTVVIVDFNQCFIYSDMGWPDPKEKSPFPPSPITRSWGSLTWLYGKKGLVRAHLWMLKTWANPPSRKYAALHRSFLERETHEDIPPEILEILESLGRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZE3</accession>
    <name>A0AAE0TZE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_432919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="12"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="950"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2413"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3546"/>
            <end position="3629"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2499"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3514"/>
            <end position="3543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3647"/>
            <end position="3666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2533"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2575"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="3654"/>
            <end position="3664"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3385176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3992" mass="435681" checksum="BA7DDB258B945F7A" modified="2024-05-29" version="1">MTSRPEYTAYPNEPIAIIGSACRFPGDSSSPSKLWELLREPRDVLREIPVSRFNPAAFYHEDALHHGTSNVKHSYLLDDDIGVFDAQFFGIKPVEANSVDPQQRILLETVYEGLERAGLPLETLQGSRTSVYVGVMSADYTELLARDINTFPTYFASGTARSILSNRISYFFDWHGPSMTIDTACSSSLFALHLAVQSLRAGESPAAIVAGANLVLGPDQFVAESKLKMLSPDGRSRMWDKDANGYARGDGVAALVLKTLSAAIADGDTIECIIRETGINQDGRTKGITMPSPSAQADLIRSTYRKAGLDLSKQEDRPQYFEAHGTGTPAGDPVEAEAISTAFFGPTSGFKRSQSDEPLYVGSIKTVIGHTEGTAGVAGVIKASLALQHGIVPPNLLLNELSSTVKPFYGNLEILKDAKKWPTLPGGVPRRVSVNSFGFGGANGHVVLESYNSTTSALPSPARSLQLSPFLFSAASENALTGTLAALASHLRANDNVDLRDLSWTLNSRRSTLPVRLSITAATTEGLISKLEELSKTPSGVVTVSNSNSSDSYPRLLGIFTGQGAQWASMGAQLLAQSKLASDRIQLLQEALDSLPAEHAPAWSLFDELSKDKNSSRVGEAAFSQPLCTAVQIVLVDHLRAANVRLAAVVGHSSGEIAAAYAAGYISAQDAIRIAYYRGYLLHLSASGGAMMAVGTTLEDAQALCELDDFVGRVVVAASNSPESQTLSGDSDAMEGVKIILEDENKFARFLKVDKAYHSHHMIPCTGPYVEALKNIAVKVQSRQEGEHYPSWISSVYGEDIETVGTDSLGAEYWSRNMANQVLFTQAVEYAVGAKGPFDLALEVGPHPALKGPALQTIQAAAGLAIPYTGTLRRGANDIEAFAEALGSLWTFLGSKAVDFTALDKVSCGGGDFPPRLLKDLPTYAWDHERVYWHESRYSKAFRTNSQPPHQLLGTRVPDGTEKNNEVRWKNQLHPREVPWVLHHQVERQIVFPAAGYLSAALEAVVQLYGIESVQLLDIQQVTIGQALVLEENSDPVETLFSLRAIESTADWVDAVFTFYSASGAKGSTELVKNASGQIRIALGAREATHDENALPAPYAPERHQFLEVEPERFYSTISEIGLGYTGPFRKLAETSRRMHEATGLIQTPEIEDEAGEKPLLLHPGTLDCAIQAIILAHSYPGDGRVRSIHLPTGIDRIRIDPWAISKLKGPAGSKLPFFASVTSDKVIDLSGDVEIHSQDGSAVLVQLQGLRTTPLTRPAASNDVQLFFETSWEAESPTSNLSMFTECKAELSEEYALSFSLERVAYFYVNHLYKAVAKAEREELEWHFKIFFEYIDHVVSRVADGTHPYAKTEWNGDSREDILSIIKRYPDSIDLQIMQAVGENLEAAMRNEINILEPMIKDNKLTNFYAYALGMERYLFDLNRMVGQISRRFPHISVLEIGAGTGGATEATLKQLGGSFSSYTYTDISSGFFEKAQERFEQHRSRMVFKVLDIEKDIEEQGYAPQSFDLVIASLVLHATRNLEYTLKNVRKLLKPGGRLLLLELTDNDPIRFGFIFGGLPGWWLGSEDGRKLSPCVSAEEWEAVFKKTGFSTIEAITPHNTTFPLPLSVICTQAVDDRVTFLRDPLSTEVQSLGIESLLTIVGGTEFAKGIEQTVRRHYQHPVQHINSLEAISHKDLPFLGTVVSLVDLDDEPTFQNLTTEKVASLKDVFRQSKKVIWVTRGALADSPTRNMYRGLQRTIVKESQHLQVQFLDFDTADEIDSAAISSRILQLEAGNIWEQESGRPELLWYQEPEVLVQSDGKALVPRVRPSTTRNDRYNSGRRLITQQVSLDDAVVTVRPQHGGFAVQQQHTSIRDSVAAIGRIEIQLSHSLLRAIAFPDGSFLHLSTGYDIKKGLRVVLVSEDLNSRVRVPQDWTVPIAVDSDEEETRTLLCVHTQLVADSVLSGTKVGEAVAVLDPGYALGAVVAQRAAEKGVQVVLLSSKGQTLADPWVSIHPRATGRSLERALPRRNLTRFFNVGGSRDLVDAFASHLPRNTLTSSESRLAVDFFSTVPTAASNHLRLALAQSSRAISAGGERERVARITLSELATQPTPLGQQAILSWRSSSHVPVHIQPATELVRFRKDRTYWMVGLTGSLGLSLCEWMARRGAGYIVLSSRNPKVDQGWLQGLADQGCTVKVFANDITNRDDVQALYKRISQNFPPIAGVSQGAMVLHDSLFPDVDLERVHKVLRPKVSGSIYLDEIFSDDKTLDFFVFFSSVAYVTGNAGQSIYGAANAFMASLAAQRRRRGLAASVINIGAILGTGYVSRELSQQQQEYLRKVGHVWMSEQDAHEIFAEGVLASSPGSTDAAEFETGFRTDKNRVKDLEAEPPMFQHLRLSNEVNNVDDGKSSKHTVKTKARLLEATDHAQVFEILKEGFLLKLQIALQADPSKPMLEISLDELGADSLVAVDIRSWFLKELGVDLPVLKILNAPSVRDLLVSAQELLSESAIPNVSSNRSVQVDGGAEDTAKQAQTPSTPAPAVVIPVSEPSPTSSTRSDFDASSESPGTPRTSAAVSETDEIDSSLEVGNGKKTNAEASRGRNTTELMAQRSLPMSFGQSRFWFLKHYVQDQTAFNISTVIKLRGKLEFDALEKAVVAVGQRHEALRTFFYTDDKTKKPTQAVLPAPVFRLERATITDEDKELQIAVQELKNHVFDLEQGEALRVQLLSVAGTNRHYLLLGYHHIYLDGIGYVIFISDLDKAYSGALNTKPAASEVLQYPDFTARQIREYETGAWADELSFWRKQFSPDLPKPLPLLPLAGASARPVNSAKLGLSGTHTSSFRIPKDLAERITQVSRQFKVTPFHLYVAVFHLTLYRYYANSQEEDGGEDDTCIGVADGNRKDADVLQSLGMFLNVLPLRLKRSPRHTFADTLRDVRTAAQGAFANSRVPFDVLLNELGVPREPSHSPLFQAFVNYRQNTTEARRILGCDGELDIVSAGQTDYDISLDILDLGASGPIRPNQYPTIVHRIDAIAAKYPDRTALKELNGRHLTYGDLTKRVAAIAEKLSEHGISRGAVVSVFQTATADWTASLLAILRLGGVYVPLDLKTGVERLSVIARDARPTAIVVDAQTSKTDDLAVLVNQGGILTIDVSQIPSAPKGDINIPIQATSTDLATILYSSGSTGVPKGVELTHSNFSHYGDSAPVEWGMREGQEVFLHQASYMFDASLLQTIIPLGVGSTIIVAGSEVRGDPAALSDVVARENITFVGATPTEYLAWARHWNHDVLRKSAWRVAFTWGEPMSKRELCEFQRLGKSDLKLVDAYGPVETTISVGHGEVPLTDAFDDDDKPGNPRFPLALVPNVSVRIVNEALQTVPAGVVGEIVIGGAGVGKGYLKDDDLTAAKFIPDGQTKAYRSGDRGWLTRDGRLVLQGRIEGSTQIKLAGIRIDLQDVEAVIAQVHPQRVRQVIVSTRKSSDSTASFLAAFVELLDDGDASPEEQARFLFDLPRTLPLPQYMRPAVVVGVPQLPTNSSGKLDRRTVDSWPLPDSSEGTGQTRTLEETNGELSELETTLSSLWAEALPQGLIQDVGRSAITSESDFFHLGGSSLALINLQALIKERLDLKVPMFQLFQTSTLGALAAVLEQLTSSEEEQNVDWENEIALPSDPLDLNTHGSKSPTQRGPPTIVALTGSTGFIGREILRQLLDNSQITKVYLLAVRKKPADIVAAYPDIFGHDKVVILTGDLGLPRLGLSEAEAASVFEVVNTIIHSGADVSFLKTYQSLRLVNVASTRELIRLAAPRHIPLHFVSSAAVARLAAASAGSDSFGSESAAAYYPPPPNTNIESDGYAVAKLVSEVLLERAAEILHLPVHIHRPSSVTGDGAGELDLMANMARYAREIGAVPDTRGWEGRFDFVRVETVAREIISSVLDAESNAEGGGAVRFSYQSGEVTIDGDDVQKSATIGGGPPLGVLPFDEWVGRAEGAGLNSLLGLYLRRAAKGGLLLPRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZE7</accession>
    <name>A0AAE0TZE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_522534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZE7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="459" mass="50937" checksum="4DA1F89A1E937D58" modified="2024-05-29" version="1">MGNILKFLCCGGKADEGAALATRPRPDFDPNAELGDEKTSILKLPAAGSFKIVVSEDANRQRYAGQPPSYDLSATALLFLLLGRALDVDMEFFFMSRSNTESHQLTNAERKKAEALDMLWYTQNWSEAKALVETNTILQNMGLVEWINANSPAEEEIQRTGPGAEGGWMASQRTGGYRQPQAGAQAVNSQGATTTETAKERFTRLLNHVRDLKVPLWQGFDQRDITLARLQKEHKSAVQKSKKQPKSLNNVRFTFEREIGRYRRLMAGNEAVPTTVLLLTGSPLQPTEADNIIKFQENNSIKKDRGGNADGVRGQGSQFCIQTMAWTEHMDEEGKDCLRRIDDAFKGDDDINDLTEVNDTLLLRKGPAAKLLLKVLNSHNKAVDSMQLKKQEDMYGRTELVRPNEHLTMPTFKEVAKILGQDDDDSDEGEEDGMVQERVQGAALVVDGGVFGNDSKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U012</accession>
    <name>A0AAE0U012_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_449971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U012"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042103005" description="asparaginase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="257"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="384" mass="40759" checksum="DD8BB1FD60737679" modified="2024-05-29" version="1">MLFSCFTTALALGLSTFVAHVKCDPELTWISENSTLPKVVIFNAKGTILSASNYSRLDNINYGSGPPLSVEHIIGNVSEALKMAQIAIINFPVVGGSAGVNSSLYLNISQHANRLLCAEDSDIAGGVMFHGTNTLEETAFGVDVTLNCSKPFVATGSMRPDTYVSPDGRSNFFQAVAAAISPAARNRGGLIAFNDRITSIFYSTKTNANTPDTFKALEQGNVGVFLGGQPFFYNTPSFPSHRPYFNISDVTTELPSVVILYGHQGFDAALMYAAVSNGAKGIVHMGSGAASLSPSARAAAVELFAKGIPVVTVPRSVTGTGMPTPQPGPVFYASYVGAPQARIMLQLALSTGQTLDEIRDLFEAPLRKAIYATVPNNQWYYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U030</accession>
    <name>A0AAE0U030_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_449894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U030"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="194" mass="21663" checksum="435744C2FEB17728" modified="2024-05-29" version="1">MFGLAHGILMAASSDNVQPLAILACQAFGATIAMSQETCLRIEMSVIKKPKPAVIKFLQVTVGYAANDCCQHFGQTKAGVQFLALAVMLTSIMDPFEGSWVLDLLLSRSAQDKTLLPRRLQRKIFWLNLNLDAMLLGLRTSLLATSFSYTRIWDLKMTLLTTSIRQRRALQSLSTRFANYVGSETIRWQASRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U074</accession>
    <name>A0AAE0U074_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_187575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U074"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="250" mass="27287" checksum="02938A1841A30C9B" modified="2024-05-29" version="1">MTSRPDSPPTTAASQDLLIDCLDIVATQGAYLVPRAGTPVSQESYDDHAAALEQHLDAVITEQICRSAMYHGAADEWPMGHTPQEVKDKRNAELKAQEELEGATSDDGSDNDDDKDKGGNGINARVGPGNPVAPRPRRPVRQADWLPTPPLSAESPLATTNRRRRWRISEEDDEEKERPAKKHVSFAQKVSAAAQDAVPNTAQQEGRKRRRTLDVGDEEEEDKERPSKVRKSPPLAPAAAAETTTTAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1H2</accession>
    <name>A0AAE0U1H2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_508963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1H2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3387069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="81062" checksum="73E1407302374D8B" modified="2024-05-29" version="1">MARLNELPASTTDNFEILRRKFLRQNRDIARINSNQSLRIRALENECARLLSENLDLRGQILRLEKEAENNSSQRIADHALEIKARLEAQLADWGSMLATLGVEPPSKRRSPKGRRFARPRENASRSPTQRRIRLDTITDAEALALREGRLPPIQENKSYPRATMNSEEIMALCSEAADSSNSPDLGPPPVSRFVEDEPSKPESPSNKTGIQWLQSEAEEISKASENRPIPRLDYGQKAASNTEAKQETQAVVVKETKPETEATPIPKPPPLISTVKAGAKRKFGDENDRPKAAVVPAGKENEISAESGKALPARDLQKKRNIKDISARLEKAAGTRTPLSVKSTNEDISSPRKVASKAQAQIPDASKPATSTRGHHDPKNALATEGRIKAEKSLPRIDVQISATADTGPLPETTDIVISEPNTPLPAEPPLISPATPGSRSGPVHDTPPPADISLTGEISRPSRRARAAISYAEPNLRDKMRRPTKELFDAVAGEGKFSHRASTSAAPVPASTGKVPGSADSSHPLTSAGELHRDSIMMSPLAQKDRSPETLPNSVVLERRKRPSVTDSSNRESLAPAPDGPGDLSSSHPARSKNSGPARAEKHNTDISSVPDIYDFGSSSIISEPPADDAESTTKAANTSTTTTTNARSSSSSRNGRRVSTATRDDKTSSSSSSSVTTEVMPPTTKSKLSSSTNSRKRASMLPPRKTPMILDDDGDAEDESAADTSSEIISKESSSARDRVSRRRSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1S4</accession>
    <name>A0AAE0U1S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_470000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16519" checksum="019A2DF382460760" modified="2024-05-29" version="1">MSESLLPETMSCRDAFDYAWHCHTVGSQWNAIYRYGEVRSCSDLWDDFWMCMRTRTFSPEQKAAAIKEHFRAREEAKYGGGKPSSEDVWQSRDKPLPPGTAFSAKFDPPIQSDLEYQKMQVERRRRIRAEMEIADNKPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3E9</accession>
    <name>A0AAE0U3E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_98342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3E9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30027" checksum="F8D5D64332C97C08" modified="2024-05-29" version="1">MFEFETVTPPGSVQCFGNPAFIPGFTCPTSSTCQLLAGNTTLLCCPQGANCRSIQPISCDLQQQTLADAPVKTTAVLGTMVQCDNGCCPFGYSCSANTTCERNSNQEIPPVQRGQSLSSSSLSTLPATPTPSVPPSSSTTTSPPLQSTTPVDSPASSGSIDTKVLLPVIIISILALVAIVGFCVWFRLKALALRAAAANPPRASTGRFDKAELDAETGIRRQTIKCEMPGTREHVELPGVSNTVPSGSFWSWSTRSGIFHAVELPATPVMDRLGAEHANSCYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3H9</accession>
    <name>A0AAE0U3H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="339" mass="38551" checksum="2281123606C47CE0" modified="2024-05-29" version="1">MTRSRVARIFSDPTSAVTQKVRRVAKYLKRKTPRTLVPPDRGPSIPTLPNRVLPSPQPSTEHPGSRLEPPDADPAAIELSVDFSYKRRGSDLFRIQVHDSHQNPSADAYTADSSGCHMFDDLTARKCPLNCDCRVVGRSHVFTAKIYPSSVFVEILSSELSETLDRVIGLENLTSTDSPHNPNHVDGFALLRHYKSLQRFLDACSETRCEKLRLLVDGFLKVGEIWARHGWARLSESGVIDDDLLKKFCRQRLVGDILKLDHGFRSADMIAPTDDDYYRYEPTDNNHFEFELTDNNHFESEPTGNDYFEDELADDFFEPSGDIWLSELLSRHPFSEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3X9</accession>
    <name>A0AAE0U3X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3X9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="374" mass="42578" checksum="2372C7665494956A" modified="2024-05-29" version="1">MHDDAALTTKLAQIVVQKLEDEVIPCCVTGTGALHYYGVPRLVDTVEICVPDDFFGVAKDLFDSNSAFEKGPAGPEPTRQKPLTHTYPSYVHCELKKLFRLMPCSEFNFKSDLAERIVRDKHGVPFPALDTFARSLVDNQQFADLEDLIDGMDLDDAWAEVFLDLDRVDAAYFQARNKAIELAFAGTEHDAALFKLFEAPLLLPKRQLLKQRWHSIVWDKQKRLDHWQSPALWATKYKARSLADLMDAKTLRGDQRELQEFTARDLVDAIDILMGVTPKKVKTLMKENIPWRVKVECAPIIKEEEECNTPTKKGGSPKKKDDSPKKKDATPKKKENMPRKEDSPAKKNDDSPKTGEIKIHNVVNQTTERYLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3Y1</accession>
    <name>A0AAE0U3Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_428256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3Y1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="85"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3389725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="521" mass="57301" checksum="0954695F6647E1FF" modified="2024-05-29" version="1">MVVDKKKSRIPPPPTDPGIEGKRTGKDESQSPTDTSSGMSDQDDDIPIPPDNTPTVTEELNTLQRAWRWKPKPARYDPENPPKFTVWMNMLFGFAACFTVSNLYYNQAILNRIAESFQVSFEKASSVATLMQAGYASGLLLICPLGDLFPRRPFIVGLIGFTAMMWIGLCLTTSFEAFSAISFICGATTVTPQLMLPLVGDLAPAHRRASSLAIVVSGLSLGVLVARILGGIMANYTDWRNVYWFGLGVQFLVLILLYIWMPDYPSKNPDGLNYFKMMWTIVHLLFTEPLLFQASLVAFLMSAVFQSYWTTLSFLLSTPPYNYSNLVIGLFGLIGVIVIVTAPIYSRLVIDKVVPLFSAILGLTIELAGIIVGTCIGSFHVAGPVIQAITVDVGAQFTQIALRSDVYRIQPNARNRVNTAYMVMAFAGQLTGTSVGNRLYAQGGWVYSGSLGIGFIGFAIIVCLARGPRETRWFGWSGGWAIRRDDLPPRKDQNVPPTEKALEEAAGAVDDSSDTRQERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U533</accession>
    <name>A0AAE0U533_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_466762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U533"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="370"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3390910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="503" mass="54095" checksum="B3B1C147D3E6E48B" modified="2024-05-29" version="1">MMNRPGAVPQSLRGITGGFGGQQQQQPQQTGRAVSNRLTNGKLAQAQVSNGSGWGFGSMPMGGGASVPPGSARQLGGNVSFAQSLSGSQPATPLDLSEFPSLSNTSQLAASNQSSMWSSAGSRGLGGAVHRGSGTPLSSQQSQQEDIFAPSRLPTVQSSFRFGNQGSSAQAPQARSSTAEEFPPLNQNANGELGGQDRAASLMSSLGFGPQVTTSTSAIHANRAGNGLLNAISANTRAVEARSPTSITRPQDLRSPVGEDEARHKPPGYREDSMASHSSVSDAPSHQLGARNPLGAIGNDPPTGKVKDEDKGRPSEVQDPLEGMAPNDKWGLKGLRTLMNNFPDYNALTCGIDPSVLGLDLSSTEMFSNQIYSLFDETPPRPAVPKFRLPECYQVKNVQPVEAKIQAFNEETLMWIFYSCPGDIKQQMAAVELTNRNWRWHKKMQVWLTKDDMMVPQALSPTHERGYYIIWDTVSWRKERREFTLHYADLDTNPASQVPGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6J6</accession>
    <name>A0AAE0U6J6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_2100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6J6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3392811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="570" mass="63947" checksum="6C3BC4BE08F0F082" modified="2024-05-29" version="1">MSTSLPETYPDPAYEQAHLDTYERKPRHPIKPVFPPGVREADFAEAIQEFIAVVGKDAVFVNEGLSDYIDPYDINEAQDGKRKVPSAAVCPQSTDQLKEVLKVANKYAIPLWTFSRGKNLGYGGPAPRVNGSVALDLHRMNKIIEVSDEFHYAVVEPGVTFIDLYNYCVEHKKKVWPSTASLGWGSVLGNTVDRGMGFGANFAHHQAMAGIEVMLADGDIVRTGQFGISNSPSAFLSKFTYGPSVEGLFLQSNLGVVTKMSIWLTPQPQAFMSCTFSMPAFNDIEVMVDSFGELRRNGTINNVVWFTSLIETLCISGRREDYWKGEGPVPDWRLEELRVETGFGHWYARWGLYGPKRVVQAQFDEIKDVMAKRAPTGEISGTLYANDDGVDAAAVPPEHGSMFVGVPQLWSLPLINWPIPKDRVGKAAHGDYAPVIPSSGKLILEWMKVSKPICEANGVELMADFFMHERHVVLMNMFTWDQTDPKQKENVNKLYYGLYEEAKKRGYGMYRAHVNHMDLIANLNDFNGHAYNRFVEKIKDALDPNGILAPGKQGIWPNRFRHLRETQEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U892</accession>
    <name>A0AAE0U892_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_506302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U892"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="226"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="477" mass="55005" checksum="2B2E860FFBCFA93E" modified="2024-05-29" version="1">MDYINKGCCREAERAEIVALGLDQLRLALPVSFHTHLIALTEEIRSSSRLLRDLADRSQVHISRVPIVLNHLGVLLPCLCKTLRDITTYYEDKTLSREIRWRKMYNKMTEEAGGLPLPNRFVLYNNFLSLLKQLLTRSPNFDLNSLEALRTRLLALREQRGIPPPPVQSGPLIRQDLMSLAVVQEPNAHWAEQIFSLPLPSRTALKHPRSSKSYGPFFPWGHLNIPAEPKILFRRPFDNDKISIVVFLNSVDQSPYILMRTIQGGNPWFSMYGVHELCIGREGSALQLKRWSRSEQASKLWAALYFLTWEEMVLFYCTFVALKARNMLTVQIHPNEFKLQREKRLFQAQIIDDGYKHSLIVYEDLQTRGIRLHAAVWEGELRQCPVWTAFVTHQSQSPTWLSRRSRHRVWLKDVQLYVFCKTYRQESMRQNKSGAFELYFVSEEGAKRFREVFSITTTSPGTSGASGVSEPAAGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8F8</accession>
    <name>A0AAE0U8F8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_460634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8F8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3394329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="133" mass="14556" checksum="86CD047C1B65D0F2" modified="2024-05-29" version="1">MGRWRIGISAVLPVPVCVSIASPGRKHWLASCQQAATRDKIFHQTRCLNVNPITLPYIRIPYGNMYRERMGRCGVRGNIDSTPGCQLASAANQHLMRIEEGGDAASFCVSQIAHLRTSTTTATRATVCDLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8M4</accession>
    <name>A0AAE0U8M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_59963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8M4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="154"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="246" mass="27469" checksum="A34C2F92D54AB9D7" modified="2024-05-29" version="1">MYSHAPPAPPPKPPGNHEASRLSRPAGARQSPRRPPSPEANASDGDLHAMGSTSATHRTRRGQLPDPGEQWLPKFLEDKSKQDLAEILSNPALLSALTHSPQTIHPSLGASHETLQSVLAENMERAAHLLDLESRLSHQRSSVQAQLLSTHALERAWRAKQADMDHALAPFVPASLYQRLSQGLLEQEGVCYALEESFLEGEGDGALATERETVDWARRYREAKKLYYLRQERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYQ6</accession>
    <name>A0AAE0JYQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_498182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYQ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041956521" evidence="1">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3366470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="502" mass="56203" checksum="1E1C1FD66BEEB251" modified="2024-05-29" version="1">MNMHTCSSAAFFQLRRLFLFVHVPRPVVTDLTTELCLYTSQQSAWLYVARANEEELAAEDLLVPPPNPSSGHSWESRLGGIWVLRSKFSGMIDQAVTEVDVLFGMDAPKVPVARLSVLHGRAKPRPNARAALRVREDSKFKIVQISNTHIVTGVGVCKDTIDVHRKYLPESEADPLTVNFIGRILDVEKPDLVILTGDQLHHDILDSKSTLFKVAAPIIERSIPFAAVFGNHDSEGIRALSHSYAFSNKLGTAQMSILQNLPFSLCESGPEHVDGIGNFYLQVLAPALSQLPFSTLYFLDWHGQKPSKIHNPDYVPIKQSQIDWFTETSQAQRSAREKVDNGNRFHLSLAFLHIPLPELGDRHLSIRNGHRREPTESPSFNSHFYDALVKEGISALGCGHDHVNDFCALLPQQTQQDGDKTPQPSLWLCYGGGSGFGEYCSYDGMRFHRRARVWELDTSTGSLKTWKRVEYAMDRVDELVLVESGAVVNPREDDEDRSYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYS6</accession>
    <name>A0AAE0JYS6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_529865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYS6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3366482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="461" mass="51408" checksum="D1A186ED8FDD0B4C" modified="2024-05-29" version="1">MVLMVAKNLLVAREKSAFARTCRRFYDLLTQEFWRDHWNQAFQWGIQHGSLHTVRQILEDSSLNVDLDKTIIESSFRAWEPLHGAVAFGHEELVKYLLSRKADVAHSSSKGLCRCATFKGTVQMLPLHTAICLGFDSIARVLLMESEADPALTVIASAGTGVLDLDMDMDMDMDMDMDMDFDNGDADSLLNLSAFINPYYHPTALHTAAHRGRLGLIDIIADRGVPMDFVPDGYSETLTPLLCAILSPRGVPVIRRLANLGANLEARIPLLDYSPLAIACLGRRYRAALELLALGASVHDWGTHSRSCNLLHLINGLSGFQVMETVQDAKAEAEALPKLVVALRMRGVDIEQMSRMALRTPLSYAFRSQNYEVMEALLQGGADPDTDYSWDIPKPLLAYFEPRHSRRSNCPKDKFIWLLLDYGAEPSHLNRTVSKRLCLSSPSLPGGASNSRKRRRVRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JZZ7</accession>
    <name>A0AAE0JZZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_535507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="387"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1674"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1305"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1465"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1628"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1755"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1628"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3367533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2641" mass="287745" checksum="47ADBCCCAAB49629" modified="2024-05-29" version="1">MATPNASGTAAGGSALLLFGSQALSFDDAAFKKLRSSFWNTSNQEWVTEAVGSLPAVWADFVKAFPKYGAVVGDQIALAHLIECFQTGEIPPAETTTEKTRQLPNIVLSPLVVISQLVEYLRYLDTAESTDKPRGALGFCTGMLSAFAVASSKDTAELRENGTKAIRLAMIIGGMVDAQEVLDPSGNARALATAWGSAQVEAKLDGILERFPDSYVSVSYDEKRATVTTAASTSSQLQSELQAAGITAHEIGLYGRFHHAWFSDDIDAVIEYCDAHPSLLKLADASSLVLPTWSNSTPPTLTSGSLHAYAIKGLLVERSNWHKTFQTAYTSLAGAGLVSVVSFGPEKNIPPSELRKIGSRVTYMTDIPIQPSAGGAVDDGRPVPRKDDDIAVVGMSIKVAGADDTDEFWSKLCSGTSQHTEVPANRVSFEDVWREKDTSRKWYGNFIKDHDAFDHRFFKKSALEMSSTDPQHRQMLQAAYQAVEQSGYFDNAAPKRKKIGCYIGICNGDYENIMACYRPNAFTAVGNLKAFIAGKISHWFGWEGPSLAIDSACSSSLVAIHYACRAVLNGECTAALAGGANMMNDSLWFENLAGGQFLSKTGQCKPFDAKADGYCRGEGFAAVYLKKMSQAIADGDQILGTIAATGVLQNQNCTPVFVPNSPSLSDLFRDVLDQAKLTPNQVTVAEAHGTGTQVGDPAEYAGLVEVLGGKQRTSPVALGSAKGAFGHTESASGAVSLLKTILMIQNKTIPPQASFESLNPAIHTTPHDNVEIATKAKPWVVPNGQLYAALINNYGASGSNASLAVTEAPKIPRNELAVSEGTGNSNVEFPIRIFGNEERALKAYASRLRQFLTSSSGATNKAAQSIANLAFNLSRQGNPTLDKSLVLGAKTIDQLVQKLGSFELGDSGSGLTVLSASKKPPRPVILCFGGQVSTFVGLDRDVYNGAKILRTHLNACDAVCRSLSSDVGSIFPAIFQRTPITDPVKLQTVLFSMQYASAKSWIDSGIQPAALVGHSFGELVALSVSGILSLQDALKMVAGRATVIRESWGSEKGSMMAVEGDLEVVNKLLVEAGGKATIACFNGPRSFTLAGTSAEIDEVVETLTKPAFSGMRAKRLNVTNAFHSTLVEALIPQLVGVGKTLTFRQATIPLERSTEVHATETELSAQYVADHMRQPVYFSQAVGRLARQYPQAIFLEAGSNSTITVMASRALGMPKESHFQALNITGDNSNGLQGLASATLTLWKEGLRTTFWPHHRTQTYEYVPVLLPPYQFEKSRHWLDMKPPPKTTITVTEAAPTNVQPETPLGLFSFLEFKGKGTGAPRFRVNTSIEKYKTMVAGHIIARTAALCPATLIIDIAIEALLSVWTPPATWQPQVHQVINMVPICIDDSRSLFLEFEVADNDNSVWDWKMVSNGPKGADVLHVTGQLVFVSTDDARAQAEFKRYERLTGYHQRCVEVLNTPNPDDIIHGARNIYRAFTEVVDYAEPYRGLQRLVGTEGKLSAGRVVKKFSGETWLDTLLSDCFAQVGGIWVNCMTDCSPEDMFIATGIERWVRSSEMATRAYDARPETWDVLARHEKVSDKSYLTDIFVFDPSNGNLTEVVLGINYHRVSKASMGKTLARLTPGLSVSAPAAAPTAKPSSAEVPMEAPVTAPKKTLEAPAPKKEAPKKEPKKATPSVDVEGEIRVIIAEISGLEPEEITMDSGLAELGIDSLMGMELGREMEAVFKTPLMSDELAAVTTFLELVTHVAGVLGVSGAEEASEDEDETASSAYSTSTPETRSSTPPAVDAQELEKPTPVPRGDDFKPTGDLKLTPEIIFEAFEETKRLTDDMIAEYHLEGYMDNVLPRQTQLCVALTVEAFAQLGCNLREAKAGDVLQRIPHEREHTRLTDCLYRLLEQEARLVDVSPTGVITRTFVAVPSKSSAILLAELLEQFPNHTVDNRLTYFAGSRLAEVLRGDLDGIKLIFGTDEGRELVTALYGDLLLNKYSNAQMQEMLRRLISKIPRWDGPLKIMELGAGTGGTTKGMVPLLASLGVPIEYTFTDLSGSMVAGARKRFGKQYPFMKFKLHDIEQPPSDDLLGTQHIVIAHNAVHATRSLVNSVTNIRKALRPDGFLMILEMTQPIYWVDLIFGLFEGWWLFEDGRTHAISHQTRWQADLQSSGYGRVDWTDGWRPEIEFERVIVAQASVHEGFSIEPTPMKFVPPPPPPAEAKLTDAQLGVQLDEFVRKYTQGFNIPIINTEATTNVLKSTAICGETDGVCVAVTGATGSLGSHLIAHLSSLSVVKTVFCLNRRSNTAGPTERQNAAFTTRGIQISAEASSKIKVMAVESSRPRLGLDEATYKHLVANITHIVHNAWPMTEKRPVTGFEERFKVLRTLIDLSGDIALYRSTVSKQAAVPFKVTFQFVSSIGVMGHHSLLPGNGRFAPEERASIDQLLPNGYSRAKWVCERMLDETLHRYPSLFRTTSVRPGQIAGNSASGYWNEQEHLSFLLKSSRTLRALPGLQGDMCWTPVDVVAATMADLLLLDPHTQMYPVYHIDNPVRQPWSSVLPVLAAELDVPTENILPFKEWVRRVRTFTGSVEDNPAARLIDFLDDNFIRMSCGGMLLETKRACEHSPSLKNQGPVSDETIKKYLGWWKQKGFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0V5</accession>
    <name>A0AAE0K0V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_88103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0V5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="250" mass="27249" checksum="186EE12189E38928" modified="2024-05-29" version="1">MQAFGGCPIAHRSCLPVGAFLPLTTAIFGSFAAVTILPPPPAVLNPACPLSYSSWTRSQQKSWTSSFPTVSRLEPPRARYAPISVAWQCAIERETFRSVTIHVFKFTYFNAVLASPLAEPRRRTLLREVTCHIPCNTWPCTYSAATIVNLFAVLSQTGSAASLTLEFLITHARGCYNHTSGTIKCAPPTRLGEAELEAFGCLPSIPIISKLRFPVYDQRVLFLTACPILSMSPGGLIRPTCHFSSTPCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2N4</accession>
    <name>A0AAE0K2N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_455308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2N4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="7">
        <location>
            <begin position="284"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3368537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="500" mass="56604" checksum="78BD455DAE6BB0C2" modified="2024-05-29" version="1">MPPLTPFISPLITANAINNQMPDPAASATTPIVPWVGSRPNPLDILPFILFYLALLFACAPPPFRGRGILFFALIATLQWRCIVSPWPPNESDTRPLRYGIGNSWIFALPAVERLLVNTPERDFWHVDGDDPVQWQIRQKPTPKEFTWKKVWWAMTIWATPRGVGWNFGWKRLNAQRARIRAARLDANRKTNDCVEGTPTGGRAEFVAVHLARIFVAYLCWDAVTLAEQKAIVPTAWAWDPLTIGRIMLLEVMMVIVVYAGMVMQFGIGAVAGVGLFLSDPEDWPPLFGSLFDCYKISNVWGRFWHQYLRQPCLGFSHYLVQKLHIPPRSLLAYFTHLMTAFAIADLVHVLSIGSVIPGYMSLRDLISDMSIFFLLQPLATIAEAIVIMLWNKYMQPKLIPTFNPETQVPMKPAAATEGDSAQSSQASSSTQVENMPLRDWKQKSMPVLVTAMCRLVGYIWVLCWFTFTGWWFIKAYADVGMADWKMPFSILEKLLIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4G2</accession>
    <name>A0AAE0K4G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_497164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4G2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3369948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="292" mass="32702" checksum="01C27D60E882BF6C" modified="2024-05-29" version="1">MTAVSTSLPVPVSERTHTSLSAKRGREIKIAKDASIVARIIGFVLSNGITLPYYRFYRQNTLLPMLSIARSLKDREQPDVISRRLQHWREKKASEFQFIQVASTLLSAAVIGCFSWQPRETQHWLGPAAWYASLVLSLSALFLSSSFSFVFSTIKNSPTRPALSNEVAMVARLSRLVLYLQLLAVVPQGKMVASSIVPPPTQALRVAIRWKMVFTWQAPMMLMAYSVIGFLMGLLIYVCTPLYDGRDFDGESKVRLFYAILFLSWATVAGATFIFCSFWTYGFVSLDGDTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4L4</accession>
    <name>A0AAE0K4L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_305759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4L4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="272" mass="30778" checksum="A109AA8D562F6825" modified="2024-05-29" version="1">MAGTVTGIELLPITSEERLAKPWKYIGYRDFVRFAASDDDFITLRRFDELHTRILLSLQDNLSELEAQLKEIDDRLSRRDAPDTDNGCIRKDQAERLNLIASIHKKIDQYDKTLCRYIQLKGRPTVHKTNVRNIKTWLSNRNEPIHPSEVEFVNAGDLISLAKVERASLRRLFEQRILAPSKGLFGLLRNRTRENDLKTTVQGHEGPVSAIGTVTIFVAAIVMLIAPLWALALMGERIVKLVVITVFIVVFLAMLNWGTVSTQFEILAATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K509</accession>
    <name>A0AAE0K509_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_551977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K509"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33201" checksum="22DB15A994D561F0" modified="2024-05-29" version="1">MRDTAAALADASVPQGLSAHPMAWTPESFHDIDGHPAYVVQLNGHHVAEVDRAVKALHGRELRGDAVSRDAFLLPTLQVVLDQACRDVHRGTGFVVVRRLDSKKYTVEENMNMFLGVASYIGDQRGMQDKKGSMIIGSYPDALRALMEPSWPIQVVDPGRLGLHPATVKAGFGLEPSVPNLTSSQLEALGVMFELATKHRLRLQAMHGDMIFINNWGLLHCRDSYCRSSKLGWDVPEPFCAPWEAAFGPNGDGCPDIAPNSKEHAIERKYPTAPAREYVPPKYMAGSAASIIDDDDAVNGEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5N5</accession>
    <name>A0AAE0K5N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_454704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5N5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041973888" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="130" mass="14730" checksum="BCE7188F3F35DABD" modified="2024-05-29" version="1">MLRQCILLALSVFGTTELPALSLFTRAGPLVSTSGDSGNSVLRSFLVIDKSKGSSYLPVQRSEEALDPDRWDIASIGLYKRQAETEQAKKMEHMILKFESEKYLSEFTNKFKQVHELARIRLARYMARDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5V0</accession>
    <name>A0AAE0K5V0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_527954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5V0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="122" mass="13184" checksum="907C5334B8E53A4C" modified="2024-05-29" version="1">MAGKFEPKTPVVLPPPKDDIIPVDVLAQANGADSSKCYVAIKGLVYDVTGNKAYQPGGSYNAFAGKDASHALAKTSTKAEDVKPEWQHLDDKEKSTLNDWVTFFSKRYPVVGRVEGATNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K642</accession>
    <name>A0AAE0K642_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_486883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K642"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="592" mass="67065" checksum="A5130CCB5656C2DF" modified="2024-05-29" version="1">MLGVARRRTWAYIFAVIVIFFIVSLRRNLDTHGFPPLSALNPADGLSHSRWSRMKPKYPVKSMRQLPTQKPQALPKVQKSFPEEADPARIKRLKRQKAVKEAFQRCWGSYRTKAWMSDELTPISGGRRDTFGGWGATLVDSLDTLWIMGMKKEFKEAVDAASNINFDGTTLEDVNIFETNIRYLGGFLSAYDLSGDKRLLEKAREVGEMLYAAFDTPNRMPLTRWKLHSAIQGQAQVAEDNVLLAEIGSFSLEFIRLSLLTGDPKWFDAAQRIAEVMHEQQASTRLPGMWPVVVSARQQAFNKHSEHTLGAMADSMYEYLPKTHALVGGLLPIYREMYEASMDTAIKYALYRPMLPDEKDVLLSGMVVTQGKDDPKLQPEGQHLVCFAGGMLALGGRLVENQTHVDKGEKLMEGCVWAYKAMPNGIMPETFSMLPCASPDECPWNETMWKQAVLGRTSMDGDPELTLADKIITSKRLPKGFTDIRDTRYILRPEAIESVFILYRITGRADLLESAWDMWTAIDDATRTELANSAVNDITVTDEKPPQSDSMESFWLGETLKYFYLIFSEPDHISLDEYVFNTEAHPFKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K738</accession>
    <name>A0AAE0K738_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_487214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K738"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6510" checksum="6CED9894E6982446" modified="2024-05-29" version="1" fragment="single">GRTPLSWAAESGHEAVVRLLLATGQVDIDSKSEDGCTPFSWAARRGHKVIIQLMSEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8W8</accession>
    <name>A0AAE0K8W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_484268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="10288" checksum="83E0A29C056A0152" modified="2024-05-29" version="1">MHLSSGDQFDLLRQPSSSTQREYPNGTIPESVGVGRCLLGRPISFVVLKALLVVLVTPVLPPMKGGNVVDMVAVFSMHVALVSCSNVGMFHGGILGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K994</accession>
    <name>A0AAE0K994_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterigmatocystin biosynthesis monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_484966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K994"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65823" checksum="4DBCE4A1818E5751" modified="2024-05-29" version="1">MVLKVNGDFAGGLMAGVPQPTGVVPEYQVREQPLGATRHIRIVGIGAGASGLNMIRTLRLNLTDYELAVYEKNADVGGTWFENMYPGCRCDVPSHSYQYSWRPKHDWTNFFAPASEIKDYLNRVCDDEGMRDSIKTSHQVISAQWNEIDGGWGLVVRNLQTGNDFADYAHFLIDGTGILNNWKWPNVEGIDSFQGELVHTARWPKNFDHSNKVIAVIGNGATGVQVLPALQPGAKKAYHIIRTPAWVTPPRIQTWKIMGQATEILSQIKIDEQENFSQETIERFKSDPDFYRTFVKTIEGEVNNVFPVVLRNGPVQAFARAKVTEYMTAMLGGNEKLSKALIPTYPLGVKRMTIGHTYLQALTKPNVEIRLEGIKRFVPEGIELESGEILLIDVIICATGFETSFCPRFPLEGRDGNLQNRWKKEVPKAYMSCAVAGLPNYFTFLGPNAPIGHGSVFTLSEHIAKYITGVIKKCQTEGIKAIAPSSAAVDDYFEHISTFMPRTAWAAPEARSWFKRDQTDGPVTALHPGSRIHFFHMLERFRGEDWEYVYDNPKQNRFAYLGNGFSSKELNPKGDSTWYLDSPSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9Z8</accession>
    <name>A0AAE0K9Z8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_291464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9Z8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="472" mass="52277" checksum="FA1DE784B73892B9" modified="2024-05-29" version="1">MEQPRPTSTPKFPAGLAGVLNSPDDHRDSAYYSSTDASSKHNSAASGMGVLTPNGSSYQASPIDKTPSPTATSNLVPHPLVSPINSNMSVASMVSPTTPGSADPRRYDRESAPNSATFLNGDAPDAFPRRESVDSRINQGFNEMRLGNSPYASHNHSTTSIHNTLQQQRHPRPGLESLAVHRISNGYQPSAERNPEGHPKTMRVAPAITGPATSQIARAAEPTKGQAWAFPEEEIQRLPSAGHSLIDSRRSSIADSLASSQYTTESRLPPGQRRLDDSYAEFQRLSSASGEFATVHHHSLQNKHLSDLQSEEGSHSGQQPYSRTPELRVSHKLAERKRRTEMKELFEQLRDMMPQERGSKASKWEILTKAISEHQRQRDHIQGLQNQMSRQQGEIELLKRELHAYRAGAHRPPQPMADQYPADQYNRQHPAELPPLRDHLQPPPASSAPESMTGVQYESSRNGFRPTEQARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KA55</accession>
    <name>A0AAE0KA55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_401255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KA55"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042077696" description="PNPLA domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="16"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1210" mass="136192" checksum="DE6C393869E86C8E" modified="2024-05-29" version="1" fragment="single">MHYLWFFLLLRAEANGSLDGGGVRGVSSLLILHDIMAKIKERHGLAEIPKPCEFFHMIGGTSTGGLIAIMLGRLRMSTEEALQEYDLCSGKIFSSSNKKWTNATEKFKATTLERIIKEIVARRGLGEMMRDPENPPKGKTFVCTVSEREIAVPRLICSFPRDDSWDEDFEIWEAARATTAASRFFKHMKLKSGSKDEGFIDAAIGCNNPIEQLLSEAVRTLGTGRRLGCIVSIGTGTRAIEMQRASTGLRSITGFLPILKGTVMTLKNTATDGEARALAIQSRLAGFSGAFVRFVVPRAAEKVGLAEYEKIQTLKDMTAEYIDTVASSINETADALEKDNLEHGLTLGLIFDLDKDQLVLSTKRAQPMGRASRHFTGRADIVSRICSFFSPRGPGGGSQREFLLYGMGGAGKSEIALKVAEMLTDQHVLPPPLSYSCLRFKLRNIFFVHGTEEVTINQSYAEIARDLNLLGAPDADTQRKLVLQALAESDEDWLMIFDNCAVENPDRYIPRAKGNILYTARSKEKLLDLADECAQKVDPLEEPDAIKLLLTASGVAASHELSDEKRSALALEIVNELGRLPLAIAQVAAHIRETKCRLENFPEEYRAKKKRILSQKFKGASREDRAVFATFEMSYSAIAAIKRREGRTAKGITADMALRALDLMCFCHYDRIHVIFPTFALAEWELWSTPRSLVKILTGGALTSERDFFVGPPSDFANIVSIVEAVRLLEKYSLLKKASTASESLVTMHVLVHDWIRSRMDPKRERERALIALVTVLESIPISRSDVLHGSTLDTYFLQTVLPHALEVQKHYRIEDIRDEEYVGRLHLKFGYLLRSEKKFGRAEEEYLKAIRILKYELGGYHGHVAFCLRHLAELYLEMGRLGEAELAALEALDRAWIGTLAETTSDSREDESRQQHVAPEESIVSSDGPSSKGKGKDVGVDSRSHEQQLPDETTPKGLVGKGNDQGINRPHEEEMLKGAPLEGSSRESEPCVDSLDGEEELLPPQDGIREAQDSLLYFDFLMAVSDIEEAISRIYWEQDRFGASRKLLACALRRRKKFLKPAHLAIRRLEDELKSIDNPWDHQYWSRRYAEIEQSDPESRAKHYNSLHARAFMEYCAASQQKFAKTHNIPFNEEQYIISSMHYRFMHKSYTNVVGAYDRETLRAMRRRALFYLDHDVGDEAEEIARDCYERALKAYGESHRETIESLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDH8</accession>
    <name>A0AAE0KDH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_252867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDH8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3374541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="491" mass="54711" checksum="44F4EC5C6133F215" modified="2024-05-29" version="1">MKEPMADLTTGSADIIHTEKAIGTVAWDENPELNKRLNRKFDLHILPWLFGIWLFSFIDRSNIGNAKLAGLPEQLGIDTGTSFNLALLVFYIPYILVDVPSNLLLKRVRAGVFLPSLITAWGVVCTCIGFTKSFAGLIVCRLLLGLFEGGILGGVIVYLAMFYRRHQMLYRSGLFYCAAPLSGAFGGLLASALGQIEYGGYDKWPWIFFIEGAITVVFGIVCFFFMPDTPAMARFLNDEEREWALRRMRMDASGSTTIDVDHEELNWHWVRMALRAPQMYFCAAIWFFLLVPLYSFSLFLPSIIAGMGYKSTIAQLFTVPPNMAGFLVVILAAHFSDKTKNRGYFIVAGTIVGICGYIMLLASDKNSVRYAGTFLVAGGVFQASPMLMGWVANNLAPHYVRAVGVGIVISIANCSAFIGTFIYLQRDSPKYVLGHSISLGALGLTLILTVAQMVYLKWENRKRDAGERDIRLVQENAMKLGHRHPSFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KGC9</accession>
    <name>A0AAE0KGC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_280479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KGC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="184" mass="20485" checksum="FFA806FAC3E366FD" modified="2024-05-29" version="1">MVIYSFYIFDRHTECIYSKIWLPPTPNPPPPPPPSTNTPTLAPPAAAHDGTAPLPPAAPSRTGTHVDRRSVSAKAGDDAKLIFGTVFSLRNMVRKLGGEDDAFINYRTAQYKLHYYETASNLRFVMLTDTATLSMRSVLHQIYINLWVEFVVKNPLSPVEHKGGVGVKNELFELGLDQFVRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK94</accession>
    <name>A0AAE0KK94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_227307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK94"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="552" mass="57958" checksum="4E52C35111A2B65C" modified="2024-05-29" version="1">MDSFKLLKRRTTDLLHSLPQSLPAMPAMPTMPTLPDMPTIKNPMAGRTAAQMKATWEKIAVPPVPRSSPSANVVAGTVYIFGGETGSAHGPDNAMHAVTLASSGAQADYFAIKAKAAVPSSTTAAASSATSKEDTKGKSPATQPELAADQLGSIPATRVGHASAVIGHRIFLFGGRQGGGGDGSMAPLDEGGRVWVFDTRTHLWSFLDPVFSPGAAATTVAVPPPRSHHAAVATDKPRDFNTAAAQHRQAQKKDQTWREWATGADAEDEIVGTVAERATDADAEGYGTLIIHGGCLADGSRASDVWAFDVHSRAWQRLPDAPGTPLGAPALALSRSRLFRFGGSTSINEDEDEEGGQLDYLDLGVDSFDDEFSAGEVSITARGGWQSLIRGKENVGYKEVDTATNPLTRGDGDSWPGARTAAALEAITVGGGREFLVLMFGERVDTTTSTSNKFWDDVWAFQVPAQGLSPASVADTVLSAVGRKSGEGRWVRVATTPYDDEDDASLDGPGARGYMASATLGDLEESGIVIWGGLSAEGGNQRLGEGWILRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKN1</accession>
    <name>A0AAE0KKN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_525728</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKN1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="17">
        <location>
            <begin position="227"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3378503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="460" mass="52798" checksum="7B9FDF8612BF1628" modified="2024-05-29" version="1">MDVLKRLARFLDRPLFPWKKLIIGFSVAQYLFEGFLGLRQYQVLQQKKPPKVLELEVSKEVFDKSQAYGRAKAKYAMFNGLYGQIQNIAFYQYDVLPKLWAWTGKLLLSFAPARFTGEISHSIIFILSFIVLHQVLSLPSSIYHTFVLEEKFGFNKQTPQLFVTDMIKSNLLAVTLVPPILSAFLAIIQKTGNNFFYYLWLFGAGLQVFMITIYPIAILPLFNKLSPLEEGKLKTNVEDLAKKLEFPLHELYVIDGSKRSAHSNAYFFGLPWKKHIVIYDTLIEKSETQEVVAVLAHELGHWKLGHTTRLFGISQIHFFYLFSLFSVFVNNSSLYADFGFTKTHPIIVGFLLFSDVLGPMDTVIKLLMNILSRKYEFQADAFADKLGYNAELARSLIKLQIQNLSTMDADWMFASYHFSHPILSERLKALNWKPTQKVEETNKAGDKSYAEAVTTGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0Q3</accession>
    <name>A0AAE0N0Q3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_405488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0Q3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3366417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="767" mass="87453" checksum="2DE994DC02A50C44" modified="2024-05-29" version="1">MSGKSPPPPLLPPLPPPRASGPLQVIPLGPPPVPPSHRYSTRRLRPLLPSDVATPSSSTTRAPLPPPPRRRAVLAACIACRKRKSKANHGGRPKCVECTRRETDCAYDTGGDETPGRALKRRFADLENQASVFENIYRILRTRPQPEADAVLNRIRAGEDPETILRHVQHGDLLLQLSVIPESRYRYEFPFMITLPLRLQTPTNNYLSSLIYEWDRQSPPKDPQEDGLEPLNSMVSADQASNAGLHGPYLRPYHAAEVIDPLIDSAEPAEWTMVSSDNALMRTLLRAYFLHEHHWYTILHKDCFLADMSSGRSRFCSSLLVNALLAMACFCHRALPKRAEFWNPYTLGYQFHAEAKRLWESEQNRNRLTTVQAAILLNLVYSLNGADRLGQIYTSQAIAISKELGLFEKPADWESMSPKVRIVRTITAWGLYGYECEYVYHFLREPLLEMPPDLELPDVDNHPEWYSEVWLKYPLQQTLYPMHFGHSFKALCEFRAIMKDVSVGYYFGRPAPRPMPSLEIIVKLYSRLGAWYNKLPEPLTARKIIFPGQMKLHMHYCHVVANMFQPLVEPPLGSRGANRTISLFPPSDAFIFNGRSAQGVLLDAQIHYETVLRLYYLRHGFEGMDSFLLLLLSTIAFKSIQEIKLSKNGDDHQGSNDLSHLNTLRSTLILCAKGLYDQGRSWFLPQSIFRLVRDAMLDAEANLLQQFANIPDEVKENEDNRLRHIQSHWPVNIVDIRMSNPEEQQLTNLLRAYADLNLETASDYADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2F4</accession>
    <name>A0AAE0N2F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4045 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_488084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="2"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1586" mass="171709" checksum="F672C326D8DE603C" modified="2024-05-29" version="1">MSDEVSDFLRSVELLKGRREEEDEARSRDLEEKILQEKRERQARRAERARSISPQKSSPANTPSPSAQRTTRATAVTSDTTLPSPGLESSGSPRARAPRSSDAMESAPDYSHSSSKENDSPFDSDSKRTSSTSSTGGPPPSRTPLSWQRRPTSQASDRPKSRPLSVVAAENAAARSSPNPPEPTTPTPTPALAPADDQSLTRDQIAQSLAGKDPTWFRQTADRGQNSPAYRRNQVEDLDVVVMSSSRVQLAGMSRGSPSVEPTKDAAASLHESPALYSKAGSPLNLTNTPRLNPPTGGDASEGDEAPSVERQPTGRISPNRPISPTKGMGGFVQSAMMKRSDSVKRWSVTSPGGLQRADSSVTRSGAESSQRSNPSKHNSRPGSMLRDGSTTPSSRPTSSHEREPEQDPVKAYPTTPAIETPPAEVQDEADEALPTSPSKTMDPRRWSPTKSSSWLEAALNKPDSPKPKQSSPAVNQPAWMVELNKAKAQKANTGSGSAEPLRSPSIPRKPEIKTTGLLKSTPMGAATVKSAGLGGFPRISPSDKVAPGGFRGTLTPSSRRGSEDPDSGSPGAGTESTLGAKTKPTTPPKKDFRAILKPRAPPLESSTGQPDEFKDVFGKLRRAKTQNYVAPDELRSNILRGKAALNETGGPKKNERKDEFKEAILKKKDEFKKTQQEGRGVPKGPGSSSSIEEKPIPEGLAKRLEISRTGTISKQSLITPGSASPSETPRTLSEFARPSHLTASQARELANSPTSSLSSRLSSESEKEPVFKLRAPPVVQKETGIASRLQTKPSSGGGLADRFNPALAGLLARGQSPAGPTKTSSPPASVGSGAANTEEPAGPGPQLAHLTKNRARGPRRKAPTSAPKSAQNLTESEKPREPVKPVEPAKVEATSPQQKKHRVTSPKPEKFTSPKPGKFVTSPRPERPITTPKPEIISLVDSRRSMVQEKPQVVGSVVPLIDPSKRKSEDETKSTGQPITLVDSSSFKTRPRSPTKVHEQVAALAAKTQHTSKPVEDDQPLSQPSSPRKLDLKRMSRFLDEQGQPTRTPEPEKSHPPSPVKAQTFPDLASTPRRQLFSDKSESGPPVPAKNNAGPFGDMGPPVPAKSNPALLGGVSLGLSHATARIEPAVDSELDQRARVPPRGARPLPPPPKTSRTPPRVESPTRSPTRSPVRSPTRSPTKSGVEVTNMLSEFFGPDRPKRRYTADAAEILMKRPATGSRVQTQRAQLFRVFGDGKKIPVPAHYERVLFEREMYLCPHSFTDGAGKKVNEVYFWAGDEVPLSTVEDTEIFARREARSFGGKLVRLSQGKETAEFLQALGGIVIVRRGSSNKYDSLASNMLCGRRYLRQVAFDEVEFSPASLCSGFPYLITQQGKCYLWKGKGSDVDELGCARLVGMDLALMGELLEIEEDNEPESFWDIFGGGARAPSADHWRLKPNYDRYCGRLFCSNSADTHQITELFPFKQTDLVPSNIYILDAFFEMYIIVGARSQHQYAAFHNALDFAQEYAILAAGMEDRPFVPISTVVLEGIPRDLKSVFRKWQDSHSPTVMNPPSYQQPATSLRRGRSLRIVPLNQALQAVQADKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2J1</accession>
    <name>A0AAE0N2J1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_535885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2J1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="322" mass="36810" checksum="A19CF69DF2CC2363" modified="2024-05-29" version="1" fragment="single">RSLSQPYIYSNNVRPLTLLFVLARTTTKSYCPFSPSLYRQLKEDNTIVSAHNKRYDGQLSIKQQLRSLFVKSRPAAQTTTAAFTTHYPGGSSSEARSSYNSPKTSHTILPPVTIMYSSSNDNAASGPKKPVGFKRKYVKAPRSLWESQHDAEADIRSQIEFAQPAAAEEPANWVEEVEEELLATQRQEESVIPASYYQGWGAGTCYSNPALTRKILKLPPLKPWHYVSPELIPDHTSAEYHEIMKRHARFQQAFAHIRAMEASPELKSRLSQDELKDVYLVRTNQLFKDLPVVCNYNMEKAVSYHVKDRQFQPWEMHNGKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2Q1</accession>
    <name>A0AAE0N2Q1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2Q1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="328" mass="37729" checksum="85A4846928FBA4E5" modified="2024-05-29" version="1">MDYNALIDIDYQVQGKLWIDRVSTFRGGLPYHLEGTFHNGAFNAGVKMGLAADNPLGLGPFIMMDFVDGVTLNDFLKDLKAERLTRLTREDITRRDHPNTTEQLVHQPDSVTGPNGAKKSYVAFKTLQALVPEMINPKYDRGNKDDFTVVGILFGSAPWWLQDRPVNDQWDYDFRDDNGTPPEVATRYFHYLEIYKRVLKEEEAKMPGYEEKELSNLVQWSQDSGAMWLHMLMSSGFNDTYSFPWTQLCPQLGEADWARREKEFEGDADELEAFAAKKVRGLDEYDTALEKRQVEKELMDSGKMTKEEFLAMQESPTPEYVILLAHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N342</accession>
    <name>A0AAE0N342_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_528752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N342"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042173635" evidence="2">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="28677" checksum="6650C7B80212ECDB" modified="2024-05-29" version="1">MHFSIVLTALVSVLATSVAASPNPNTHAGGVVEGTCTTGGNGNCAVREYHNGKWNNKNVPCSPDKRARVRERRQQHNVDDAGGAGKAGDDADGEDADSFNWIPFLLYEAYGDGGQLWEKLPDSMEGLLRGTKIEAALTEHMATRTMEFSDANEMEGYMSIKPEEIVFLKHQHQKMPEMEQAYADRFLAVMKKQAQYDRGSKEWNDIQNEERKLAFQDLRIAEHVVRVLPAIVMRAEEMYKEIGKRLKKLHERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N390</accession>
    <name>A0AAE0N390_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">deuterolysin</fullName>
            <ecNumber evidence="4">3.4.24.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_442494</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N390"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF5">
        <property type="entry name" value="DEUTEROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041987260" description="deuterolysin" evidence="16">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="17">
        <location>
            <begin position="212"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3367799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="356" mass="37456" checksum="A4DB27126CD87232" modified="2024-05-29" version="1">MVSTILTVAAIAGTAMASCPLSVKLAGVAGHVAQVSVTNTGAEAVTVFKGNTVFSDHATKDLIVSDASGKEIPFEGVYVNYKKTGLAPSHFQTIQAGETITVSVNAARSHKLAKIKSAKVQAIQGFRYALGATAPDSLKDLLSCSDIITDAVDITPDQAIAAEEHITKRAGVSVVPRSRIAKRSITYHSCSTSQTSSLQTSVSHTISMASAAYTAANTALYYYTTWFKATSTETKVRSIYNKVTGVQTTSPTISCTDTYSDCTDGSALLYTVPSANYIVPCPNNGFWGFPEYATTCADDDYDRAGSILHEVTHLYGTGDYAYGQTAAKQLSATQAAANADTYEIYAGSVRLGGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N407</accession>
    <name>A0AAE0N407_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_305427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N407"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3370001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="663" mass="70410" checksum="8A865F8FE06CF30C" modified="2024-05-29" version="1">MVSVNVVLNRDFEGAGESAVSSPASVASSSYACTPTSSTSLNTPGPQITIRPSTANRPPAINTSAAAAGRIAMSAAASPGATTPLTMTTKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEELLDDEREDHERTVRELQERVAHLETETQTLQSRCQWLEALLEKERQGREGPMAGSWESNSQQQHQQQQQPECMMIPLPRQHLQPLVPKNQPESILIPEPRPMGQSFSISQIISPPDEADGSLDLSCGNCQSNGPCACANEVLRNTDIIMGCGGCTIDTRCACLEESMRATIDLKRPLPPGSPSPSMTSGEKRQRSDNTGAPELMDMETDFTAMFGSRRNKEPLPSVVPMPDVHLHTQPQQPMMSVEARDNCGFCKDGSYCVCADSMGLASMSSFSAPGLSSGPQQLQQQQQQQQHITQQTHTPPPSEDDVVPMPMEVTATGAIKLPRFNGLGQSQQRAAATLTRPAATKAGGCGPNGPGTCTQCLSDPKSGLFCRSLAANFERNNRQQQAGEPASTSGGGGCCGNGGPGGCCMSGGDKPAEVVSGSINSAASGRPTTNNSVAKGGLGLSLSCAEAYKTLASHHHFNEAADDIGSWLPKLRAVPVPPELNHNGRGHLAGGGRAPIEVEAASIMSVLKDFDIRFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N523</accession>
    <name>A0AAE0N523_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_564688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N523"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="119" mass="13113" checksum="10AFA2B188F3FB37" modified="2024-05-29" version="1">MWPAKVSLCTLSSLPPRLTIVCTRTSHTSRDCTRSICHTSPSRLFSTLSITPPIGRSAVLRGFDGCQGIVPLHIGLLQVFLTGRKKGGRSLHEITTVWPKVIRVPRAHSAVKQILYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5X7</accession>
    <name>A0AAE0N5X7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_526778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5X7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042291583" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3371906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="73" mass="8045" checksum="9AE817B74A6F8B23" modified="2024-05-29" version="1">MAILAKAIARLPLTLAIALNMQNIDQLESLIGEMFAKNMSVVKKEAQRKENPGREKPPMPPGPFPLVVSTEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6D6</accession>
    <name>A0AAE0N6D6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_484579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6D6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="19525" checksum="575BF14B0282C4F7" modified="2024-05-29" version="1">MSQSLRPYLQAVRSSLTAALCLSNFPSQTAERHNVPEIEAQTSPEVLLTPLTIARNANESVFIEPSVNSVRISIKIKQADEIENILVHKFTRFLTQRAEQFFILRRKPIKGYDISFLITNFHTEEMIVKKLVDFIIEFMEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6E4</accession>
    <name>A0AAE0N6E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_485047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6E4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="510" mass="56631" checksum="971E1AEC17E64653" modified="2024-05-29" version="1">MTGPKNDTETRPEVEILVHRSAPATAAADARYRALAAAYLAFEPARRTLVYSTAEHHAQLAETEEPIPKADSIPSSVQEHREAECIPSSVPQPAVLSSPQCSFEGASDNLASPRLRVTEVETNTQDSLSSWKTPPSVIPDSFPENNLTILEYCSPTRILEHYLRGLGSSESNSVGGEEVDRPLNGVQESAQKPIAELPSTINDSWVRSRSDKLAVASTELPQVDAPDFNGLPVSSLPSIEYDSWVVEAVDRSQQKEMRPTVISLSPTVNLKRRRPDGAPVSTPQEYIKSTYPYPRDTYDAEVGTSSRADSEPPPLKRFRPSPGPPDAGKPLTRSTSDIGPRHNEKQRKLEQDPSSQISQDELSTEIIAPDPMTSTSGLCEADMVTEAMKQAANDLKLEKRFRPKSQTRELRPFERGYWLVDSTSWSDELKKTAWRFLTTYVGEGCAGWGVNCRRDPTFTWIRLYSFGCVVGHMWLLLYLASNRETNFTGMTWISGNGKPIIAMEPKPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6X2</accession>
    <name>A0AAE0N6X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_298809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3372495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="542" mass="59482" checksum="D1CB3C2B7A27F7A2" modified="2024-05-29" version="1">MPPRRSHKKSRAGCRRCKSRKIKCDEVHPRCGNCLKHGVACDFEHPEVLVEIQAADAASPHSPSALSRAPSTPAASVDFRSPIDRASVPISAATFASIPGASRVATPLCRPPSTPSISSTTPASHRLLELRLMHQYTAMTCKTFTFTAPVTEEIWGITVPNLAFSGFQHLADAILAVAALHLRSMNPNDKELVRASHGYMAASLAEYSAALTRGIDHTNAESLFLTSALIAFQSTATRVFMKDELSIGGGAGSRADGESKERGAAAGCYAIPFSWFHSFQGVKAITAASWQYLRVSPVVTQVINSQAVLQLDFSTGPNTFFGHLLDGLEEELAELNASSASSKNNHANTPSGHAASSEQQHDQNNPELIASTRQAYQHAVAVLNWAHKIPHKGAPLAFPATVSRRYIELLEERRPRALAILACFFALLKSMDRVWWLQGMARREVLGVMSLFNSDFFGPDAYRKWWPHLEWAMRIALYEHTGNGPIPAEIWGADWYAEEQALAEGQEHGNYFRHIELLSQMVSPVHSVPVVPDVYNQLNHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7H3</accession>
    <name>A0AAE0N7H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_291619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7H3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="505"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3372299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="625" mass="69750" checksum="2FF5C1FE7071A801" modified="2024-05-29" version="1">MASQSMSIPGASPSTNPLDILRLAIAKELAHATGLDAGFIFASLDRSATIDKGDLILAVPRLRIKGKPPAAQAEKLALQFRTDECPTVKQPVAEGISLQFHANPSELLGDVLPFVLEKGDQYGLDPSIGLREPSASGGERKKIIVEFSSPNIAKEFHVGHLRSTIIGAFISNLYEGAGYDVVRINYLGDWGRQFGLLACGWERYGVQEEFERDPIRHLFKVYVQISGDFKPEEELYKAAKKRGEDTSVLESQGLLGASKAFFKKMEDNEPEAIALWERFRALSVERYKPTYARLNIRFDEYSGESTVKKATMTNALEVLEQRGVAVPDQGALVVDFAKHGPAYKKMDLAILRNRNGTSNYLLRDIGAVIQRHEQYHFDEMIYVVMHEQEAHLRSLFKTLELGGPPYDGISEKLKHISFGKVKGMSTRKGTVVFLDDVINDVSSYMHEQMRSNEAKYAEIPDPARTSELLGISAIMVQDMMGKRANNYEFDLKRMTSFEGDTGPYLQYAHARLCSIARKTGFTREELLKADFSLLTDAPLAVGLVRVIARYPDMVKQTLKTLEPTTILTYLFALAHQLSSSYDVLRVVNAPEGPEVTRVRAALYEAARQTLRNGMVLLGLTPVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7M4</accession>
    <name>A0AAE0N7M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_550999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7M4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3372434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="430" mass="48010" checksum="2FD484D3E7E892BD" modified="2024-05-29" version="1">MTSRYRVEYALKTHRRDQFIEWIKGLLAVPFVLYSQPQGVFDGQGTASTSLVQAREEAHRRYSEILRDIELMIDDHIVHQNDAENPFPSKLKLLVPSIGLFFTRLPLEAAFKFQDRKRYISSRRFVSPSFNDVRLILNSAQIMAVTTYGTLQLATFDGDVTLYDDGQSLEPSSPVIPRLLDLLRKNVKIGIVTAAGYTTADRYYARLHGLLDAMANSADLTPTQKQSLVVMGGEANYLFEFSPSAPHLLAPVPLSRWLTPEMATWDEREIAELLDVAEVALRDCIKSLNLPATVMRKDRAVGIIPLTPDVRIPRESLEETVLVVQKILELSTAGRRRRVPFCAFNGGRDVFVDIGDKSWGVTVCQRWFGGHSPGGIIKGENTLHVGDQFLSAGANDFRARSVGTTSWIASPAETVELLDELAELMGKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7N3</accession>
    <name>A0AAE0N7N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_527306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="296"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="687" mass="76795" checksum="689834BA4BB2B0C7" modified="2024-05-29" version="1">MAPRAEGSHLKRARISGSPSNDGQESFKKIRRSERLSQRVDNNDGRKTPISTRQQLPSPVTNDPSEGTVELFKEATATPPEGRPSQVSHRNPDDNFSQGLAFSSPPQDTQAFPSQHVDPNAPLSDEVEDEVKEGVWGYLFPMDTRYGGRCVVMRKRATCPLPDTVSESLPSGPSRRGGRRGPRALIKDQEALDKQNIGGLPSGGYLIGRHSECDIVVDDPIISNRHCLIFTENKGNDTVAVLEDLSSNGTFVNEALVGRNQRRELKEQDEIAVLDKARFIFRYPKSRHTSAFLQQYTPQEKLGKGHFAEVYLCVEKSTGQRYAVKIFSKTPGVEERSKNEGLQQEIAVLMGVSHPNVLCLKDTFNEPNAVYLVLELAPEGELFNFIVQKQKLTENESRKLFTQLFQGVKYLHDRNIVHRDIKPENILLVDKDLHVKIADFGLAKIIGEESFTTTLCGTPSYVAPEILADNRRRKYTKAVDVWSLGVVLYICLCGFPPFSDELTSPDFPYTLSEQIRKGRFDYPSPYWDPVDDLALDLIDSMLVVDPERRFTIDQCLAHPWMTKKMIGVNDSTNGLVSGIAGLEVNRRGVARERTLLSSINQVQVANRVPMGDNKPDLKIYSKNKGKAPVPKETRPADQRDPRNFMAMGGKGDPELFGNDGDSRYSKNEILEAQANAGPKSKRKEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N927</accession>
    <name>A0AAE0N927_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_275680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N927"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="797"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3375312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="865" mass="93927" checksum="E4E40911C28434D7" modified="2024-05-29" version="1">MASADVERPSTDEAVSPHQQNVPPPVMERAIRSVGSLNNPLNSLDMRADPDAQATVTDFLDFTEYLPSDMMRSLTIIGKLDQTYINESASLNDLTRLWSNQPAVPAAERKPIELRAQISETLHHTMSSRVYAHAEAVRMSENLNRHCNRASTILTKLETMLENYPATDETKSPVVTAKSPQISRAPKVTPRLDVSHRARRPRVPRITVPGEVLAPYELNYDAYTSEGESSSDDDDDDDELLPTNRLTPAPQPRIKVVKPTPKTPKPTRTPKPAQPAMSSSLALALLAPPPENAVIGSIDAPWGQLTPWELARLRKRMKKNVAWTPSDTMVARELNELGRGVEAFRAAKQKAEEEGKDFDGKMPVPIKDPDTGEKHMPLGSLPLDAMDSDDKNFSNRGMKLNEAKKIKRELMAKQAADEAEESARKFDAIARELMLHAPKPMAQDQTPKAPAPSSKAKAPKKRKRESVAEAEAEKPELAVEAHAPQRPQFKRTKTETPVPPPHLTVVSSQINQETPVPPPHRTPAPAAMLHSTTPIPLPVHGQDQSITAKSGTSVASGASPTPSSAAGPSSTIAPVKLPPAETPIPPPLHSPKKSTTPILPPVRETRKMQATRMQESQKEPPKEYLAPLPANPPSRASSPEPLHPKPDPDAESADAAYPDINPNNSASISTPATRRPTSRGKAASQEPQPSLAADRPRRASTARNTPAPEKPEPTVRPSSKRGVKRPAPGVISRTVSGGNSAVGTRKAAPKKKPARAGANNRPSTSKDSKSTADAAGGGEMLEVEVDDEGNVIEDDEPRYCLCNRVSFGTMIQCDNVEHCKQEWFHLECVNMAAIPARTTKWYCPDCRISLNIGEKGEVNARGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBM6</accession>
    <name>A0AAE0NBM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_235563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBM6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="479" mass="53381" checksum="1FAFA33DB2587E91" modified="2024-05-29" version="1">MPPPKISIGDLPAWAHLNSIAFSNIKVAKSEGKGYGVICERDLTSPQDSLDTPALLTVPHDLILNAAAVEEYAKEDRTFRQLLDAVGPRSSRRVLLFLLVQTALASRGSYHSSAGVLNPWTEYIQFLPETVLVPSLWTEDERFLLRGTSLESAVNAKLSALVAEFDTIREISSDIPCWNEILWESETLSFRDWILLDALYRSRCLELPKSGESMVPCIDMINHSACPTAYYDENSEDEVTLLLRPGASISKGEEIFISYGEAKSAAEMLFSYGFIDLESTIESLVLPLDPFPDDPLAKAKLFAFGEAPRVHVSRQNGSIVWKSPFAYLMCLNEEDGLEFLILQETRQLNVLWQQEEVTNRMAEFETLIQSHPLCSIFKLRTITVVHGCLQSQLERAQSNMIDALPAPKADSSPRQECVQAALLLRRIEIGILEAGIEALEDEKTTLLTDEHVVSYLGSMETAESDLVDEEASNEADDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBM8</accession>
    <name>A0AAE0NBM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_477943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="697" mass="78153" checksum="BABFF0318D4ECB0E" modified="2024-05-29" version="1">MAVLASHLQGTSNLATRQYGDLTALDSENASTKIQLQKVPAPNQVSKWLFDQEQHLIDGTMEDVSKPRSNRGSPPVIIDLSAMDLDDDDEQPGHNDSRERASHRHHKGHPASLYSSQSKGPVWLPLTGARPHKRKHSYGGHRDEEVKIVETLPSDWRRGLYVAPKRRADGHMASPSKKLKQSQVQVQPQPQPQKPRRHHAQLEPVAEEISDVLETIKPNSIFGMIAPEIRDKIYRHLLVSKKPIQVKGLWTELVRCTTRRSDRRRRLAGEMVDADADADNTIDTKILRVCRLTAAEGTRILYSENSFLYLLRDPECCNKMMVSLPIRGMSGRAANTNSMDGVDVGNNGTRSRCTIGSRSRRIARVVESTITHDRTINIHKFGHLFRHMGIELEPNRTGAEYERLMQLALDILANGTENKVFLDTLAITVSPVFEGNRRTVLDENGNEVEVHGGRYLSVVNLFSRGSKVLKALQQIDTNFIRINVHIPPAPAADSASDDGNDSDESDDEEHQDRGGRAKQDGGGRRHLETTLDLRFLSRHLETVRREGPIGELWSNDHLICEHRKALGEAAETALSGLRHRIEKACTATESAITQGLWEDHAVAERRRIQRRARDDAKLDGYNDATDKKKRTRRQRVMMGDDASVENGDMESDDDGMSDQDETNSEDDDNSAGPSWAGRKSLILSIDRVGGQWKAYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBU7</accession>
    <name>A0AAE0NBU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_561744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBU7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="346" mass="37652" checksum="C590F6AA4A5054F4" modified="2024-05-29" version="1">MPPPKKQRWLAPDLEPDRVWKNPEVLIDDDMAFPGCSSEANLTGKATSSLAHQVVSPKTQHLTPRNTINTTRHGTPVTFEITPLKCIACAIGGNFRYGKAPSDILPTTSFDQLRQKKHLGNGTDRCVWKGKTCVSKRIEFDEDIEIIEREVRTRESLIRAAAATSSPSPSPPKPPVAPPSSAATKATGRRHTKSPSPPPPPSTQILERRFHVIPLLAVVHKHAQTDEALGVLMPHAGTDLETLAGGCKYGMGLLEGEKPPRRPWPVIPVTQEQLADLVLGFVLFDLGTVAPDYKGDAYALGEVMLWVLDRVEWKGGKGSDAARVREAARLLKGKGDFEGALKVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC80</accession>
    <name>A0AAE0NC80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_478945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC80"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="24990" checksum="94F67AF79CA80A94" modified="2024-05-29" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRATVDDFPLCIHMVSNEYEQLSSEALEAARICANKYLVKTAGKEGFHLRVRVHPYHVVRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQIIMSVRTRDSSRPLALEALRRSQYKFPGRQKIIISKNWGFTPLRREEYLEKKAAGGLLIDGAYVQFLSNKGSLKQNMKRFPDAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCP0</accession>
    <name>A0AAE0NCP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_250919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCP0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042080766" description="Protein BIG1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3378555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="274" mass="30229" checksum="C3B62FB8EEC0A767" modified="2024-05-29" version="1">MQLSIAATVLACTGAAQAFSDSSPFYMFSSSELPTSLNHKQLQTSNSVLAQAQKYLSTCPTQYYILVSQPNVHADDIHDVEFRCTMPNLCRAIGSETTHGRFSVREVIGKVLSQPLADHITVSCAEKGKAVKVEEVALPRLPSTKEAKRAETLADNDHELGQRLETLGDDYTVIFFSDPNEFKAYEPDFAEAVHMNLKRQSKSPVLIHSRLGNSTRTLPLFEKYQFFTPGIFMVFVALVVMLSILTVGLKALVSLEVSYGAFDKDMGPAAQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NDB9</accession>
    <name>A0AAE0NDB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_250615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NDB9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="37009" checksum="9CCF821D6EF13C69" modified="2024-05-29" version="1">MTASMDDETTMMGHNSNDKANQDAEIENEIAELERRLAEAKTKRRQRGMNTRSEDECIIKQPLNDTPSRPLLNANNSNNSSAQHFLLLLSDSALPLGSFAFSSGLESYLAHSKAGLSPSPLPGAAPGGSFSTFLPLSISSYASTTLPFLLAAHRDPSFASIVDLDDALDATIICTVGRRASIAQGRALLSIWDRSFAAGFATTDEKKYNANPVAAATLKPFVALLKTSSSSDSTTGNGGAAMPPPVAAHLAPLFGAICNLVGLSLEQTAYVFMLGHVKALVSAAVRAGMFGPYQAQMTLAGGTVQGLITAMIEREWDTPIKKAGQRLPVMDLWFGRHEVLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG36</accession>
    <name>A0AAE0NG36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_523617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG36"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3380878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="194" mass="21451" checksum="7D2D6139F5EDC08E" modified="2024-05-29" version="1">MGNCSSCLGNRRADEFDEDDEAQRLFDDSANLQYGSFDQQQMMGQEDPLEVQREIEALQRVVNRTSEYIRPPLLFLFCPPLPGAHAHAHVCTTRGHGLGTNMVDIYDIVPQENKVVQPAPAPYAYAGQDARMARYQTLLSKLSSHGDLTTAVARVDWGIPEDDTIEMQQSPLPIKLEGGEALVGNFADAADAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG57</accession>
    <name>A0AAE0NG57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_560722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG57"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042242745" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3380908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56060" checksum="67EE5ADB29D49B65" modified="2024-05-29" version="1">MSFLRLLVFSTAASMAMAASSTPCDATISVSLGPCNISIDGQQTAYSWGALLVVNRAEICAAPSSFVASPLIEHQDVCSEQQRDGMTAEQCRSRRGNYVTSQDINSTASPPDLLALNPNLKFLRPDRVTNDPIQFQIGTSVSTLSGLITSGDQHTNSHLPLNNASTVLENLKSKGQIGARSFALDVGSQQYLSPRKGRLTLGSYQPAMVKGSFWEYKIDNNRSALNDRLCPFQVQIQEISLRIANLATPVVLVSTDSNSWACIEPYDRQFRLPSTGLTLLKNNLTASGFSEAAEESGTPVGRFGELLDIEPGLVFRKASYKPNSPLLADLISSMQIILRGGTVRGLDTPLTVELPGNELVQPLRGLNKQGAPVWNTSYEELLVYRNSSSLGSAPVLGRAFLEKLYMFVDYENSVFKLGHIDPDGQVQLPISSNLACDTSSSSQQSSNDDKSPWHIGLLGGLIGGICVVLLLGAGLAYFFRRKLEALQERVNKLERGVGNTPGGHHTTPQNAPSPVNTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGE6</accession>
    <name>A0AAE0NGE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress responsive A/B barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_523740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGE6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="100" mass="10884" checksum="D448486E99F61D12" modified="2024-05-29" version="1">MKADAKPEDVKADCDRFLALKDTCIHPTAQTPYIKSVTGGKDNSPEGFQNGITHGFVVEFALAEDRDYYVSTDPSHLAFVASIGELVEKAIVVDYNAGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGP6</accession>
    <name>A0AAE0NGP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_197445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGP6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="302" mass="32727" checksum="F2D7C7334A4F3826" modified="2024-05-29" version="1">MDRSFRKRWANWREARREGARDGLKTHSSVASTATSATPSTASPTSPNGAASLALPIKQPLGILRPSAKLQAFSGRTFSTEVQRPEQGSADYRPVTPSGTTTGHVTPTPAFGDHDHAQRSNIDARATGHHQPAAVSQAPPSPPSIEPRAEPKAIESTEQPTSALSVTLKDPSQRQAHMRKLVEEGQAKVSTLSKITQGVGNAVQFVLSAKAMVDLAIQNIPQAALPWVGVCIGLQILLNPVQAIESNLVGIAHVISRMDWYCALTEHILSQNNIVVRKESFKSVQFRLENRIVELYKALLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH38</accession>
    <name>A0AAE0NH38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_204661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH38"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF20">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="599"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="762" mass="81168" checksum="5EBC6753A711F237" modified="2024-05-29" version="1">MPARYYPRHRGGVTAPRRAMVTAISLVSFFILAIVALAQLREGGSRHSAKFASRAEHVALGKEARAAATGDKYLIGVGKADITGPVVEVNMAGYANTDQVGSGLRQRLYSRAFIVGEVGKPANRFIYLILDTQSGDTAVRFGILEGVAALGSSYSVYGQSNVAVTGTHSHSGPGGWFNYLLPQITSLGFDKQGYQAIVDGAVLSIKRAHESLQEGYLDVGATNITDANLSRSLYAYLANPATERAQYSDSVDKTLTMLKFKRASDMKNIGVLTWYPVHGTSMLGNNTHISGDNKGLSAYLFEQSVKGESTTAVGFVAGFSQANVGDTTPNTLGAWCDDGSGTMCSFETSTCADGKSQSCHGRGPEFQKLDLGVSSCYEIARRQFAGAKSLYTALGSSSTAVVGPTVKSFHYYNDMRYFKFPLDNGTIVQSCPAALGHSFAAGTSDWPGAFDFTQGDSGAPNNPLWSVVGGLLRVPSPEQVACQSPKPVLLDVGEMETPYAWSPNIVDVQTLRVGQFIIIVSPSEATTMAGRRWRDAVKASATSLSLTNGVEPIVVLGGPANTYAHYVATPEEYGIQRYEGASTLYGPWQLPAYVNLTLQALPYLAPTATGSPPPGPSPPDNRKSSLSFITGVMVDNAPIGTSFGACSAQPKASYTRGAVVNATFVGANPRNNLRLEGTYAAIEKLAADGTTWSQVRSDEDWSLVYTWTRTNFVLGYSSVVISWETSGSDAAGTYRVKYYGDSKPLIGSIKAFFGTSNSFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHG2</accession>
    <name>A0AAE0NHG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_476005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHG2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="315" mass="36937" checksum="57AD561F3690C9A6" modified="2024-05-29" version="1">MAPTINYTMEEMSRNAFEYLFQRHLGNIPSPTQFPQQLQNCRIQLENTVNECCERFYTKCLKAGVTQDAYRSALHFLVQDFLGSLSAHSKFPQELLSEQIDLKRYIGACDAEIREKCLISSKSLPWLPCHRCAFSSHHSDTWWNHLLTHERVHEEEWHVDNSVFRLEPRWFKSHWPGCIECRGWDNSQCHRPCRNQQQVTDCSRCRCARMVYKTMTVRHACGFCTANQVFTRWNNYRGHLREHYKTGASTSEWSNLRVMYALICGDNVLYDALSKDLYLSERDGPLPKDWKADKNTLWSQVELKGLLSLQDSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NIA1</accession>
    <name>A0AAE0NIA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_477132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NIA1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3382016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12464" checksum="5861B6DA672A1429" modified="2024-05-29" version="1">MQRSTDMDTRTLHPRTRDVGDGRMRTCFVPYSGQPILLTCSVAQLFFCFFLSSVWLRFLVVPSNAVLLALEVGFNCRCAARWKECGGKGRRKGRCGLLCIFVFSYLFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNG3</accession>
    <name>A0AAE0NNG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_169192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNG3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3384739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="606" mass="67198" checksum="ED69954659EEB9DF" modified="2024-05-29" version="1">MPRFSIGESIPPDTAHAVSVSLPTWESNVGYEEGQEWVVSRMTTGYPRFFIHKSIEAFAIDVVAKVGAKGLRVMLFPTRQIALRCANFIRSNAPPALVTNLDVVHLVLDTVNPSSAALEPVFPTISAVLFSQETFPYAKQYWQHTGDGVSSRRAEFCHGLFKDGLLRLDDGSNSPTATQSQKLCRGPRRYRRMSSLDAGKKSSLLGNGSPVRPAAGMGDVQETSRFLEERFGRNLDVSFVEPAKSAIRRRIAGALRSDHELSTSPLPEMESNSRGILNLKEEDVYLMPCGMNAIFNVHRALLGSRGSLKSISFGFPYVDTLKILEKFGPGCIFYGHASESDLDDLESRLKGGEKFLALFCEFPGNPLLTCPNLVRISQLADQYDFAVVVDETIGTFANINVLQFSDVVVSSLTKIFSGDCNVMGGSAIFNPNSRYYTKFKAFARREFEDAYWSEDVIFMERNSRDFASRIERINTNAEAICDVLRNHPLIKTLYFPRYNESRPNYEVCKLPGGGYGGLLSIVFHHRAQAIAFFDAVDTAKGPSLGTNFTLTSPYVLLAHYQELDWAASFNVDPDLIRISVGLEETDEIVNVFQSALKAAESVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ54</accession>
    <name>A0AAE0NQ54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_185447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ54"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="456" mass="48978" checksum="21F662C0484339DC" modified="2024-05-29" version="1">MNTPASNKRYACDRCRDQKLRCPRTDQNTSEPCARCQRAGAICVTSSTRPLGRPRNARSSRNLHLDPSARIRRPSPATTTTSRAVTKASDAATSSLPSVAPSPSSISTPPTPWPGSTNGDIDLSYPDIFGNDPNTTLFPDPAESWDAGMNSLFDLQSPHGNINNDGNLLFPSPTPPGIMMGMQDALAPSTCLHRRHPTPPPITSNSSSLTVVNSTYPNIAPPVSPTDTLLSLSRLNGDITQQISLINTFPWSSASSVSDSECAKVIQSMGGNPLAQAQQSAARFVDILRSLLATPPPPLPTESSAVSEQPTTTLLSTPTYLLVLSSYVQLMHLYDTMFVHVCQILKDLPRSTIEDYLPVGADFAGLPAMPGSLYAKIVIQIVEHQLESVEALMGLPAEHRICGRASRSRGIFSGHQDAEGLLGAVLGSQESTTAMDKVPMESLRENMKKARELIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQJ2</accession>
    <name>A0AAE0NQJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_494646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQJ2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="40190" checksum="56FA74B64B8FFF5D" modified="2024-05-29" version="1">MAQTASPTATMRSLGVRKYGVPSEYEVLELPIPAISNPTDVLIRVHAAGIQTGDTQMAGGSFKLVAKAKFPFKISLGGAGVVSAIGPAVTAFKPGDPVYGAYFKHGHVFPPPAPGFASDYVVCPADVLLPKPSSLSFEEAAALAGSVVTAAQCIQRYFELTGQPRDTASLEGKTVFVPGALSACGSVFVQVVKNVFGAEGVISTVSTAKMGLVKELLPEGVVDMVLDYKTQNVVKEVGKGKVDLVLNTQWDMVGTFPLVEPTRGAVVSIASVPSERTVRKMVGESEKVPFLWLVVWVLRAAHWWYAWKLRGTNVKQDFVSGNMGDRETVEKSGEWVAAGKIKAVMTVVDLDDIEAVRKHCQMVATGKGGLGKLVVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRN3</accession>
    <name>A0AAE0NRN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_558151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRN3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041980476" evidence="3">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="37969" checksum="94E4E62650C65F5A" modified="2024-05-29" version="1">MHLSLSLAVIAAAIVAPSVAETIAVPAAPDTVVSPDATVVVPIGIPATEVFSAPSVVFASSVRIPDDVIASPVREPDGAVAPLVGSAPAGIAATLVGSAPAGVVATLVGGPDGILATPIRELDDVIATPVRVTEAGSVVTASALLATNAGTAPLAANTIRIMAGKSPYFGPREIIAAVGDVLEFHFAVNSEMDVVMGDVNSPCAPAKKGGFYSGPFVQPDGAPNPNVFRVTINSTDPIIFYSSVGNQCLHGAFGVVNPTCASEMLKQYKQNVDAVLPSATRPSGDAFGGQIVSVPLQETVLVRANPDWSTPGTYVCNVAYLPTLTGAGNVPRVTAGPGKSNNTGTTRDTTTSGANALTLGTVSFFGMVAAIGAVFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRS4</accession>
    <name>A0AAE0NRS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_137159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRS4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="320"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3386523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="746" mass="82495" checksum="82D7F85C68AA2141" modified="2024-05-29" version="1" fragment="single">EASSFYSSSVNTAVQSNIKVSHQEIQPHLGQLQARPSPAMMKPPLAFWLACQLLSAATPAFSALVGFGLDPYSTYCARACLWSLLPYQLSCSAKSNYGFGWSVTTPECKGNDTSYLTTLAWCMHVKCTAYRTSELEDFWEHSATADLLKFMDTSYPPPPKWGYSESLAHISQPPTRELTAADLVLNFTALVPERSYRVQLNTAFSVSQEQILGNSYAIAILVTGFGLPVLLTWLGYLPFMTRLIDKVSPYLIYPSTIGTYQVRPLPYLLGNAPTCGQALYVALFFALNVILVSVNYQSMQPHAYYKTESEEIKALIFKRTGIVGYALVPLLILFSSRNNILLLWLTNWSHATYLLLHRWVARIFLLHALVHSFLALPLFLANRTTTASEYWAWGAVATVLPVLIFVGSVLPIRRWSYEIFLVCHIVLSVLTLVAMWYHVIKWAGFVWGYETWIYAASAVWFFDRAARVGRVLKHGLNRSKVTDLGNGYVRVDVPGVAFANDGPGMHVYAHWPTLSLWRPWESHPFSFVPTALLLPKQEKVADSRISRSSSSREEGAIGGAGGESSPTAKETVVVADVEKYASPVSQSRVNLGITLIIKKSTGITKYFQADEGLLTLLDGPYQNTPARDVRRCDRLVLIGGGIGITSLLPWVANHPNVKLYWSVKEAARCLVEQVEGALSRVERDVRVGTRLDFAGVLAQEAEVGYKKVGVVVSGPGGFCDDARAAVVAAGKKGVAVFELEVDAYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRT3</accession>
    <name>A0AAE0NRT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_137429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRT3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="647" mass="71099" checksum="E6732ECDAB0DC244" modified="2024-05-29" version="1">MLLYTRRAPPKEPKKRSRAGCINCKEKKKKCDEGRPHCSRCAERGAECAYETVRPRQRKKRDSVVSGGMSPIIPKGHDPFRKFSLVSLESHDTDGSFWEDEDSERVLLSYLDDTFGTGLPDSTYSGIPLVAFSNVDFTGVSRNMTPTTIPVEGDDAEDVATEHSQESYGTVSIVPRSKALHSDLAMIAPCPVGSPLLNFCPSAFSEFSTRPNRRALVDHFCNVLSHLIVFREETGNPFQQLVLPLTQESSPVTNAIYALASAHLEYRGCQNTERSLYFHNRAIQGVAHLIEQNGNVNKNEILAAIMLLVYYEVLVQKGRSNIVAGHLKGALTIMCTNPEPSDPTSVFLERAFRFYDVIAALSNGTAPLSAPPTPGCLLPFPPLGAPAASPLCNVDTLLGMATTLWPVIHRLSNLLSLKTELESAVRGNAAAAKIAVLRTELETSAEAIEGALTRWEPLLPPNFSPDETVEEGRENKEPTIMRNLRGNICQDSPALSPTMTPTERGGMHSILNNALAYRHSAFVYLYRTIYGHPRSHVAVQAHAHISLTHCVSTVRHAGPMGALLWPLFVAACEAVSAEDRALAETAFELVTKRQGMRNIERAWAIVQEVWRRADLAELWNIGGHGKCAGADLWRQVSRDMGVNIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRU1</accession>
    <name>A0AAE0NRU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_136865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRU1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="150" mass="16544" checksum="5A3AD683C999C9D0" modified="2024-05-29" version="1">MATATASSFKTKDYLSLVGQFPENVPVVVIHFLRFHPVAIYPPDSPFASLEPISGRDAFYKRYAPAGTAAAKEVGIAPGESRFFSASVTSLLLHSDVPWDIVTARKFASFADYAKYQASKQYQENAVPHRDAALQDWSLVACIEEEPPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS09</accession>
    <name>A0AAE0NS09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_139165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS09"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602:SF2">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042055502" description="Small secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16793" checksum="1F0677C00FB4F1C9" modified="2024-05-29" version="1">MQLTSLMLTGLVSALALAAPRSTGTRFARLEEDSKQWIFQRMTRTCDSVDVFCDWDFKISRNISWLAPVPCKFTVRSANGTKASQTSSKGNVCGQYRVSMGWNGQFGTGNGFTVMAVNDIQYKKVAYPAYADSELVNGQPVVPDKFSPAESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSE9</accession>
    <name>A0AAE0NSE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_430575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSE9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="356" mass="38319" checksum="CEC11F147AB7659D" modified="2024-05-29" version="1">MTNKTLIFKKAPANALQIPVAGEHLVIEDRPWDATAPPPPGGITIEILWASYDLYLRAKMRDPEVESFVPAYPLNGPVTNDAVARVLKSDSPDYKAGDLIQGYFPLAEYATLDKDALTSFLSSGGGKIQNPHGLKDLGLFLGPLGMPGLSAWCGLYELGKPKAGETILISSASGAVGQVVGQVAKLEGLKVIGSVGGDDKLDFILNELKFDGGFNYKKEKPADALKRLAPKGIDIYFDNVGGEHIDAALESMNQWGRVVLCGMASQYKLEPEERYGVKNLLLALAKRISLRPFLVFDEGFGPAYTKDHQAKMQKWLADGSIQAKLAVTDGIDNAANGLIAAFQGKNFGKAVLKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF1</accession>
    <name>A0AAE0NSF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_468512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="176" mass="19342" checksum="DE5F1CE30A654913" modified="2024-05-29" version="1">MALNSFAGLANLSAPAVTLSIPTLSKDFHLECDLNPKISLGSGPGNTLYNWISFTGGVWNATWGNGTIESGGHDYQYVLPELAAKLDTRYLLMTSDTTPAYIEIKTDGWRTGPLDVLQALNDPVRADDVDPSTYKFRLFISMNTGDPRYNHVNTTMWLASGMRKGAKVIYDAYRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSX8</accession>
    <name>A0AAE0NSX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_447797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSX8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="11903" checksum="2984C80D3482EDBC" modified="2024-05-29" version="1">MNANEILEAERKYSIVGILQVGTAMEWFIDATKSITIAIMTFRVMWGPLPRHAGNKDFEGFDFYSALAALVIIGVLSPLKAVFAVGFAGAVNLVVDFAVASIRLTMSGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTF1</accession>
    <name>A0AAE0NTF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_469954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTF1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="295"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="655"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="969" mass="109309" checksum="AB7FBF73A2B6F5AF" modified="2024-05-29" version="1">MASPDDSDDGDELQDAPGISQGPGRRYVSIRTIFISWAVDQGTEYVDEVRKAARKMVRVGELDEIQAGPKEGQFHRDVKARLSASNAAFDLIVVVYLGGIQYLGGISARHSTVAHIRPLKSTTLLWGAKAGSMYWDMQDFLDTEADVLFITNFASRDFRRCLSRAATRSASDGVKQHCLQLLTFNSNDPKRFAESLSRFTRGQSRLERSSPLLGCSIADACHDFDERDSDSDRDGSSDWLTKIFAVKTARAKSKPSLVRRDILSGAVDIWLARPYPIFGPEHVKLSEPDGYHRRARQMKIKPTGSHAQIWIMALDYRPNPSDPGTFNTVFVVVKRFLPPPDVNNTVETRAFERVFELERRNLIEMMKRPHPNILAILGSFELPHRESFNLIFPYARGRDLFTFMRLSKETQNGKARLYPSAPLACNDYGPLEHGVLEECIGLLDAVSYLHDPGNFDGKIILHRDIKPANIFIHDRKFKLADFGIARIKSSVTASKTQGWIGTEEYSPPELFDPSAAAEGMSDKFGRTRDVWGLGCVLLELAVMLAATSRNDHIPSVERFEHLRVRSSEHRGNQRHNGDDEDSHGEPGTKTFAKTMDCVRSTARLVTDLGDSHLTCLVETAMAMLEVDCKKRPVASRAHEHMKASHATLLREEFHSSLPDDPDASPPTTHSGVPGSRTNTHQVPSSADPNNPGYQSFPPAPPDNLAQFWYMAFWHNDPVRSYYDVVYLANVILSVVIIPVIVGIYSITSMLADMDTWKPDQSTFIGTILMMWSIIQVPLSGFVWYFLSHIIFIVVPCYLLKRFIMWEAERYVSSYPCTISSTATSNNCLGEDYAELTDYEFDPYRATTITEAEGTTRNISSLLPEIEDVEVDDRESDSLHELRWRQRRRQRRNFADGWRAVRTNARAGTRAGKAAAAWAQKRVFKSLWQSLVFIQTQIDQVANYSARMERERGQRRRNQGQVLRTGAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTG6</accession>
    <name>A0AAE0NTG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_521378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTG6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="716" mass="79050" checksum="8C1B47786944D3C6" modified="2024-05-29" version="1">MEKRSSPNGALPQLTCELCRERKVKCDKLVPCTNCLSAGVVCVPVQRLRMARGRHVRNRDRSSVLDEDLKRRVRRLEALIKAGGGASLPEQLAPNPTSSGAEAPLNAAGNHQPEKRAILMQQPAHFWADLAEEIHGLRDVLESAPNNETDAEDDAGLALEPEQVETTMFNSVHRGISVLGLSEPSSHIFQQAARVHPTTAQKLCQVYLQQVDPIIKILHRPSLGNFMLHGGGYLGYQEGHPSTQVLSAAVSYAAAGSMTENQCQKNLHTGKSSIVADCRRACEAALERSGLLYTRDVTVLQAFVLYLVARHCEERSRAVWTLFAVAVRIAKALSLNLDPRKVPSQRRETFFEQETRKRLWLTICMLDVQVSIGMTSQPLIAVDEAMAGFKDPPRHVNDADFDQTTTHPVAEREGLTDTTYAIIKYKLQLLGRLTLFGAQDSPQSETKKSWDNNDHAVKSDMQSRQQHVECFEQEILGLMRLCDPESSTYAWFTLHSAQCFLAGARAIVLRPLQRLREGSQPPPPRVRGNTELLQLTAKVLEKAVLAHTDARGEGFRWSVTIPWHVLAITIAECYICADDASGDTDVADIIRRVWPTVEGTYRIHEDAVAVAIGSTSCDRLQGPMRRLIKRTREKLATILEMRPNNSSQSGATSSNAPGMASSASMTGLDANSVPSFEVPTSMLEDPAWGIWEEFVSGISFDDFGGPDPLFFSGENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTN7</accession>
    <name>A0AAE0NTN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_521372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="196"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3387314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124988" checksum="9E8944F645300D29" modified="2024-05-29" version="1">MPRNRARKRTASPASEGPAAKKPKPFTVEFADEKINKLEDRLSQTQEEMLRLKVQQGRIEAEQASAADKGKHANEKKKGLEEEAAAIEFISFGADVCIGIVHYYKKLAAYHEDIKDMIVESSKVMVKLQKSITDLQKKLGEITGSNISLGLSGKISSQMRRLLYPLRKSTIPRLQEVVEDSVEDIHDLMTKASHAAIVDDLEATTLLSEAVIAEHFFDATSRRTTSMMSLLASITYQICCGLGDDAAAIILAEIKDKRGRAHQQYEATAGDLYRAFGVAKAQATKCNRRIYIIVDGLNECDDIETLRIWLQVEVGRPAETAMWLLSNRKDSLLDQDSMLKHYTIPLVVGEAEVLSDLRLFIQHHLRVLSENISEEKKQELSEHLVRKSERLSVRCVDCFFDFLRDQQVYSNAEIDDALEMMPKGIFALYDRIMDRIKDVHPKKTQALLEWLIVAQRPLRLEEIADALAVETYSAVFELSPELCQGHVTECCALFIQEQAKLSMGSSDSLRGVIRGWESDISPESMEEHASDKTTFTYQAKVHLGFTRRDVFDEFPILSYIAQNWPVHVGECIKTDGFPLPLTRAPFYSVVDARRPESSPSDEYQKYKDTCVRYVSAYSIDIGKVPPLYAAVYFRWEAAVFWMLDNGLLYDGNRFDPIISSPLQLAVLRRFPNIVKALVDAGCRGNENIIRMLAKPLESSPEELYKAWSAPGAYLLAGEKGCVNKAAIEAVLSTLSLPFNAQWLQQVLQEKLWFTSSEDEMVDFLIEKAKELVEDGASIISFWGVAFAAKNVPLLERLLPRECDDIDTKSFNIALQESAVQLGRRMAPRDKFMAGTASILLFMSRRTAAIIQRDSLGVLAIHGYHQIILLPMRMALQKSSNPELTAELAAFSNRVQGTTLLHPGLIDFYYDKYPTISQLLFSAISRLPFRGELACYLADWLVLRHTAGDIKPPILVLDPPAIVLWQASPDWKALHGDKTEEPRPWGLGLVPHGPGDGRMEVTGPPGVLKIDDIEAPLWKFVRNVVHTHGGGADMTILPLFEERAWWPAGSGQLSDVWLFKLDEGGLIELRILQEATVAKRRNRDGMQLYKGVREGIIPIPDVETWRRERQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTP2</accession>
    <name>A0AAE0NTP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_159356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTP2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43505" checksum="ADA8FE8B415E3836" modified="2024-05-29" version="1">MSVRGKPIVPATPRVISPSPTPSEKDAAARESYFGPTTRSAARRRLTTPQLVEEDLEDESPDLRRARTRSRSPIDTRKVGRLTSAKPTAKPVANGHTPIASAPLTNGHGLEKSATTKSNGHLLPPTPSIYTGWSWRDFSRSPSPLGLIPIHRHWRTFVHKHEVPRKALHVSIGFFVVWLYLSGTQTLSVCPYLMAALVPIAAVDLARHHYAPFNRFYVKVFGALMRESEFDGYNGVIFYLLGAWTVLYCFPKDVGVMGTLLLSWCDTAASTFGRLYGRFTPRLRRGKSLAGSLAAFLVGVGTAAWFWGWLVPTMGPYPGDEHFMFKGTLSLPSTLAEAVGLTSAQATISGGTALGIMSLWSGFVASASELVDIFGWDDNLTIPVLSGLGIWGFLKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTT2</accession>
    <name>A0AAE0NTT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_470490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTT2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53130" checksum="EDE2E8BC5572B98A" modified="2024-05-29" version="1">MDDSAASQDADLADDSAKAQLDIIEVVPEGDLLLDVTFETSKATLKAARKAARPRPGRPIAQPALRPKVRLSYRVDLATLKGHSRYFSNLLGDTRFSEARSIAEALEKLSIRKVKPSEADAKELPVVKIHEDDEAARTAGRETAFEDLLRILHGKDAVTKPTMQYLATLAVLADRFDCTAPVSRYLTHGFKYKWPATQARLSKEDGHALSRPAEETLRQKILVAWLLDQPLKMHTATRELILYGSRKWSVSFDEEEASTAGELIWDLPDDLERELQYRRECILNTIASIQRHFLQLYTSRTRQCKLGYESSSSCDSYQLGEMVKFLVGRDLLQLVDFSTNSFGEIKDHSTVEIGQIIVTLRQCSGYQIDKNHTNCGLRIRLLPILDYIQSMLSSNIISISRPTWKKDRDSVSWFPSEEVDDHSEPTVFRFTRSTAMDQRFRFEGAMATDRLARTLFTADQWDWTPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NU33</accession>
    <name>A0AAE0NU33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_509325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NU33"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="2">
        <location>
            <begin position="172"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="456" mass="48507" checksum="5F06A865174F576C" modified="2024-05-29" version="1">MAASTVQNPPAQTESKSAKKKKAKAERTESPAPAASAPSKAASVTANDKEDDLSENQYIRELQKNIRNVNKKITNSAKIENVIAENLGKSLDDLVSLKLINADQKSSHLKKPALHAQLAQLEEQLAQHKKIDAENRARITKHEKILTEKFEKEKADLVSELNKKADAQASDKLNESLLILSQFLRLAAARRVEPTDSGSDENLALEGVLLHIYSGDENAVATMLKLVQGVDEPTRSTADEVLNTTFAQVKELSVAQASGIVAESTVEATDSEVVESKEPEAAVDPTVVNASLTEIEEGSAAALTNGHSQEAPSTSVPSNADVADSAANLAGESQWDTGNDLAMSQEWVDVKVPNKEPSEPEAAAVPAPTPAPANTQSWADDHPEPAAAPTDSQDGFQNVQGRRGNRDGGYRGRGGDRGGYRGRGGFRGDGRGRGRGGPRGGNANRGPRRGGEEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUP6</accession>
    <name>A0AAE0NUP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_448667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUP6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="536"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="768" mass="85872" checksum="8AF1193278B56133" modified="2024-05-29" version="1">MLNRDEVSENLWKWRYKLLHLGKSDEKTLSDFSSADTTADEKAAAGKTGKKSRSSLAGASSTAANTELGSSPSIKTLYEGPNSHDTSYEWVDYPPKQLSKSAAKAQDRVAIKVFKIKDTDKPVISGRASLRYHMIEIQNPLLVAALAEILKKQEMHLDVNENATFRHPFPELFFGYDDIVTAYQALEKDGTSDPLRPFLLLLIKLLDDMFAETRAKLENLRASGLVSFKLAWAYFPRNTTMITWGNNCELLAKVTDTSYHCAGGLHFMVIEGKVLRFNGRGFQWEDYQVKLRSFGGNKPITELPAYPLEFHDGAEDVKARLTERGRKVLEYQGLAYVNYSGIAIHHEGKNVQKHNVDGRVLIDVVGYNKHHLAQGVREGNDPQTKRQQLIVGDDDADGEDNAEEDDNIVSNRNTNLREQAGASASAAAAKAKSATKRLGLAAQKRNEKALLALEKQEPHFMYMLPLIEGYALKNKVWVSFFVEDISPLAWNDAAYDHLVYDEQQKDLVMSFVENHGADAARKRPKAMQDVIAGKGEGLIMLLSGPPGTGKTLMAEAVADRTHRPLFYLQAEDLGINAAILGANIKKVFEMATEWNAVILLDEADVFMAERHPQDIARNELVSIFLRELEYYRGIIFLTTNLYSTIDSAFRSRVSLHLLFNSLTPEARTMVWRKFLDRLPPHPTESAGEVGDEGEAVSAAVEISDDDLKELAAWQLNGREIKTAVKMVRSWCDHKGYAMTLSRIENGIRVTSPHASKSSNEKDTSLYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX74</accession>
    <name>A0AAE0NX74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_537075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX74"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="180" mass="20490" checksum="6B956AB8526983F9" modified="2024-05-29" version="1">MKASQICVWALELASRPTRGIGIILNELLGRSITGSRIEHVQHFQALMEDLPVPPNFVEHHGARSPTRKLAGMLAPHALTRRASEYPGQLPLNYLGNNEEKPALATKCRWALTRKFDRSFEDISGRVRAMENQHSFLHNHNICFESKKWQLIEVHTESRGTCLKQSAFPVSEELEELIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZC6</accession>
    <name>A0AAE0NZC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_446608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="576"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="808"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112776" checksum="BB527CDFCBF9CE7B" modified="2024-05-29" version="1">MLSGTRPSAFADKRGSGAVADRATLTSAASSSRPPRLSAQQQQPTAGGSFRNDPSNQRTDPNSDRDRDRERERERDARRQAQAQAQAKVQAQSPQLGGFAAASSSTAHKRTASGNPRQASSRSVDERRTERVQVTTRETLVSRTRSPERRSASSRTSDAPRPRPPEPKPREAAKADSFSQAPPVPWDPEATLLPHTSAPLASRISIPPLASSAPQSLQPTPLTELTLDAQEAVIIEDLLFVFMGFEGQYIRFAKGYNPNEERDRLSGPPWRILPGLDPSLQDLTMSMLRMATHYIALEMFVDVQSREEFGAVNHALCASIRKLLHDYLVMIAQLETQFLTSDTFTLHVLNVHILPTSHMMFQIYALAHDLLKRNALLDDETDESSDSGADDFDHILEQLRDHGDLVPGNMTGKKICKGGVVLGLITKRLESMSGDPAARTLLTALLRDASRPYMAMLNEWLHHGGINDPHSEFLIKEQRSIRRERLEQDYTDEYWERRYTIRDHDVPPQLEGVKDKVLLAGKYLNVVRECGGVDVSLQVRDVPTSFDDNRFLDNVNNAYAHANESLMQLLLTTHALPARLRSLKHYFFLDPSDYFSYFLELGSSELRKPVKSVNTGKLQSLLDLVLRQPGSIVSLDPFKEDVKVEMNEITLTKSLQRVVNITGIEQGESLRPLENQPVDNDKNASGFTSLQLDYIVPFPVSLVISRKTVWRYQALFRYLLSLRYLESQLSTTWQTHTSGFVWAHRSSSRNLEIWKRRVWTLRARMLVFVQQLLYFCTAEVIEPNWQSLMSRLREREKANENDKDKDCGSGGGGPDVPLGGTSGAGATKTGGPGAKGLTRTVDELMQDHVDFLDTCLKECMLTNSKLLRIHSKLMQTCTAFVTHSNWLSREVEKADPDLSGSAKPPNMTDDQWKHFQAVRAHPAPSSGDTLAASASNPDTDAARIHELFEVIKKWEAHFSRHLQILLDALNHYAATETVVLLSLCARLSTANQGTEYAGMRNDDDALAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZJ3</accession>
    <name>A0AAE0NZJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_120735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZJ3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="224" mass="25715" checksum="8BBA37D32D9E8551" modified="2024-05-29" version="1">MEAIDLIEARTSDIVSELNADNTIRSHPIGYSCGMHTAGDYLLFLYQAGGYFTKRFVLLQMLVVHLSMIFKRRFVVVLNKAIGWYIIADFEFIVRKIALNDQHELQYIPTMMYLDEEVANGTHIPRPRNSWVLYRQLQQVVILLENPGLTAADISGLVASMWLIERPSIKAHFGRIADREEAEHRAMYPEYRFEAVRAPRLPPSHAHLTVDPMAVAERLITEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZM8</accession>
    <name>A0AAE0NZM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_466092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZM8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223803" description="Secreted protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11494" checksum="E23D1C58E3711758" modified="2024-05-29" version="1">MPWLSSCLPAWIALATRWAMRKKAASLSSFSSSSPSPLPSSSAPALSRTGLTFSSGWPKRAVRNSSRSGEGKLASRNYGLEPRHTTLGGWSRCMTGRCCRPRYLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0E2</accession>
    <name>A0AAE0P0E2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_128554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0E2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="892" mass="100528" checksum="80E348754D1A88C1" modified="2024-05-29" version="1">MATERLPQRERRPSVGAPIVDITGAVSPAGISRPKHKRTFTGFGAGEIKSVEASIPEPQREAWLKHQVDGFKDKDGFERDVVRHVETTLARSMFNCDESAAYSACSLAFRDRLILEWNRTQQRQTFTDSKRLYYLSLEFLMGRALDNAMLNIGQKDLAKAGLADLGFRIEDIIEQEHDAALGNGGLGRLAACFLDSLASLNYPAWGYGLRYRYGIFKQEIIDGYQVEVPDYWLDFNPWEFPRHDVTVDIQFYGHVNKSTDESGKTIAHWEGGETVKAVAYDVPIPGYATPSTNNLRLWSSKAASGEFDFQKFNSGEYESSVADQQRAETISAVLYPNDNLERGKELRLKQQYFWVAASLYDIVRRFKKSKRAWKEFPDQVAIQLNDTHPTLAIVELQRILVDLEGLEWDEAWNIVVNTFGYTNHTVLPEALEKWSVGLIQHLLPRHLQIIYDINLFFLQTVERAFPGDRDLLRRVSIIEEGQSKMIRMAFLAIVGSHKVNGVAELHSDLIKTTIFKDFVTVFGPDKFTNVTNGITPRRWLHQANPRLSELIASKVGSNDFLTDLTLLNKIELSVNDPAFRKEWAEIKLANKLRLAKHIKASTGVTVSPDALFDVQVKRIHEYKRQQLNIFGVIHRYLTLKALSPEERKKALPRVSIFGGKAAPGYWMAKQIIHLINSVGNVINNDADIGDLLKVVFLEDYNVSKAEIITPASDISEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGEDNIFLFGNLAEDVEDLRHSHTYGSHTINPDLAKVFETIEKGTFGDTQDFSGMITAVRDHGDFYLVSDDFQSYVETQGVIDEAYRDQEGWITKCITSVARMGFFSSDRCINEYAEGIWNIEPLAVDKSDGVKKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5S5</accession>
    <name>A0AAE0P5S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="316" mass="34912" checksum="C95E308C41521477" modified="2024-05-29" version="1">MATPTTSDGSVRKVTVKTENYSSQVQIPQSYIPMAPKRQVNQQFGFPPAQQPANQNYTASFAQRDISHGLGCDQSRPELNMVPTRSELVMAPAKLSAECQKRRFNPVWKESSRPVRGTCYYVCNVIIDGHLVTGIECLSAREAKEWVANKALVIIRNMPIKSRPLGIPTGRHSGPATKRETLFDAYRHMIGARGQDARRDRLGSVGRGDRRPSPDMTEAQIRPEKPNLARLIDDAVKEGPKVAKALLDGIALGLGTQFTGMTADVRRSRTLEAGGRSSGARAHVRGRTPPRDRSRIRQRSPLRHSRYIGGGGSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P695</accession>
    <name>A0AAE0P695_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP11 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_460143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P695"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="333" mass="36476" checksum="D24DEAD0B10D0089" modified="2024-05-29" version="1">MATSRMSSVLRHLTTTGCCQLRTLRASNQRRWAQVHDVRFLTTEQPARAVLEKYREKLDRKAREEGLPDIDALKKAYADKIEAARKQQAIEDAALAATAAASAAGPAPPPPATGAASPIATTTQQRSKLASSSRNGGGVKPLDAILDLPKVRALPVKELTAIWRLRHAEKPNSLCAVIPADTYAAMEATARLHPQFVVPVPHPGQGAEIHFLQWTWDPAANGASTVLFTQLAEYKARGEFTTPHTTVTHYKDLAAEKGVVLMQGHVADDKGVTADHAQWLVMCLQRFYGGWDGVGDDAARERAEERKRLLSWFAKGDSRFSVEKLLEEAERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6I2</accession>
    <name>A0AAE0P6I2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_491719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6I2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3394189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="411" mass="46260" checksum="759A20662CA2395A" modified="2024-05-29" version="1">MLSRLQGQPESYDKKAKYRFGRTLGAGTYGIVREADGPDGRVAIKIILKKNVRGNERMVMDELEMLQRLKHPHIVKFVDWFESRDKYYIVTQLATGGELFDRICEQGKFTEKDASQTIKQVLGAVDYLHRNNVVHRDLKPENLLYLTKAADSDLVLADFGIAKMLDSKDEVLTTMAGSFGYAAPEVMLKQGHGKPVDMWSMGVITYTLLCGYSPFRSENLQDLIDECSAAQVVFHERYWKDVSDDAKDFIHKLLQPRPEDRWTSERALAHPWLSGENATDHNLLPEIKAYLTRARLRRGIEMVKLANRIEALKMEEDDPENSDMPKDSTLAADQSLSTPAPQANEASSGSGGAPSASASGSGEKRSLSKTIKGAIFREVVLAKVREMKEQEQTLKLTEEVEKEARRKSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6X8</accession>
    <name>A0AAE0P6X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_491697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="108"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3394125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="635" mass="68977" checksum="B0AF919C60DFEB82" modified="2024-05-29" version="1">MSTLGHKEEWLAQGSTWSMREPAPYDKPHRRRPVARFFDSFRRDPNRSVLPRPITNSIDDPERVAAALGGGLDDMATREHHGIHYFDISAANFRTANTHLARELKGRHLQMIAIGGSIGTGLFVASGKSLNAGGPASLLIAYAFIGVMLYCTVQALGELAVTFPISGSFSAYATRFLDPAWGFAMGWNYALQWLVVLPLEIVAASITVGYWNSQLHRSIFVTIFLVTIIIINLFGVKGYGEAEFVFAIIKITAVIGFILLGIVINIGGFPDEGYLGGRYWQDPGAFHNGFKGLCSVFVTAAFAFTGTELVGLAAAETVNPRKSLPTAIKQVFWRITIFYIVALTCVGLLVPYNHPKLLGAKSMADASASPFVIAIESAGIDVLPGVMNSVILVAVISVGNSAVFGSSRTLAALADQGQAPRFLGYVDRRGRPLAAIIMASLVGLLSYLADLDQQSDVLNWLLAVSGLSSIFTWGSICLAHIRFRRAWFVKGHSLSELPFRSQAGVAGSWLGVIFNVVVLIAQFWIAAWPIPTAPAGASSSSAPPDTLGASSSSAPALDAPTPTAVQNFFLQYLCVPIVAVFYLGYKLWFRTSIVRIEDIDIDTGRRDFNLPILVAREIDEMQSWPLWKKAYKFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVF5</accession>
    <name>A0AAE0TVF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_194590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVF5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="51369" checksum="52F7CFFE00AC98C2" modified="2024-05-29" version="1">MAFPFILHARQRCQKWQPGCKDDNDRDDRRDDRNDRDAKNWPGGWWPPGWDNTPKSSTTSTHVATTAKTSAATTTAKTPTTTTPAANPPKATTVASPDPSPTAPQNPVLPNSPDTAQPQQAPQPQQGSPDVNTPVGDTASTPASPNGNTPTSTGKPPNPIVAAPGVAPTSAPEVGSGSGSESESGSVVPPSDVNSPAPSGGGQSSPAVPNHASGSSGVGGTGGSSANPSGAAAGTGTTSSVGTGSKPGSGTSNGGGSGTGTNTGTSAFNSIDKPPASSGLPSAAIAGIVVGLLVLLALLTLLFKFRKSALVQRMMTPSTWLKGPPPPYTESGSAGDGMGSTLLGAGAAAGVGAAAATQAARSQPAPPPMREAGASPPSLLVPTAAAAAAGARPDRNNRISSPSPTSPAFSPSPVSPLSSTSFLAPAATYSSHPQSTAVPDTRYAPGNYARSSLESVSAASGVFSPGLNAFPMPPVTPPISSPNTSYGGGGIKGQYINFQQSSETVVRIPNARRSGNWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVR7</accession>
    <name>A0AAE0TVR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_200786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVR7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3381336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="25485" checksum="5F3C35F7309C4739" modified="2024-05-29" version="1">MPSSPSSESRIHSSQFDSIPDTVEAFRNGEFVVVLDDPGRENEADLIIAAESVTTQQMAFMIRHSSGLICAPILPSRTIELELPQMVESNQDLRGTAYTLSVDASDPSVTTGISAHDRALACRVLASESATPASFRRPGHVFPLRAKHGGVRQRRGHTEAGIDLCRLAGKKPAAAICELVEDGVEVPGQALREEPGMMRGEACVAFARRWGLKVCTIEAMVQFLEKTEGKLEVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZA8</accession>
    <name>A0AAE0TZA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_509935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZA8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="281"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3384997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="732" mass="80639" checksum="A8EF49740796A17B" modified="2024-05-29" version="1">MTANDAGEATAKRAASVAQTTSTPAVKDTSSAPSAIPPPIRGRNHPLGPLSGAEITQSSGLIQASWPESTRFQFRVITLYEPPKEELVPYLAAERAGEALPAVDRRAFVVYYFKGTDALHEAIVNLTKGAVERNVRLGPFTHPNADGEEIIAVEKAALAHPDVQAEIAKLQLPEGTVLVLDPWIYGSDGLKDGMFYDDKRVMQCFLYMRDPKNSSEADSCHYSFPLPISPVIDPATMELIRIDILPTGHDEKVKPLSPWQPVEANEYIPEAQTLRTDLKPLHVSQPQGASFTVENFSELGRRIKWQKWDFRVGFNQREGMVLYDVHYDNKPLFYRLSLSDMSIPYADPRSPFHRKAAFDLGDAGAGTMANNLQLGCDCLGSIYYISGVLSDSEGKPVNMPNVICVHEQDAGILWKHTNYRTNRAVVARNRELVLQTILTVSNYEYILSFVFNVAGDMTYEARATGILSTSPVDLELTKVPHPFGTVVHPGVLAVHHQHFFSLRIDPMVAGHGNTIMYDEAYAIPRDPKLNPHGVGYTVRKTEIETSGGYDLDPSKNRVFKIINQGVHNTVNGATVGYKVMVPPMQGILADIDSYHNKRAEFADRSIYVTRYAGDELYSGGLYTNQSRGGTGVRAWANRKDTLKGGDPVLWVQFGINHVPRVEDFPVMPAEVLRVMLRPVNFFDKNPALDVPPSTQDFNRSVGLNDSLEFKAAGLTLGGEGGKLSACCGSHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZI5</accession>
    <name>A0AAE0TZI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_449323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZI5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="260" mass="28717" checksum="B75E95D0971C59DA" modified="2024-05-29" version="1">MAVDSSEQDLATNVDGQYPPSSPYGPAQSRLVTPTTSLTPLVPSGDGPSLSSADWYDSYHQEAPSASQAIPEPDQRYHFNQPSECNQPGQFKQLDQFNHPVPSFDSCNGWSTTQVPPQWTMNQTLTGGLYYNAQPGPLNMSQSLQSVPDVAAGSSALTQQLNEQNNTGTSTRIKCNICNKEFRNQSNKDRHFESKHNPNVPKYHCVCGYTQPGPRKDNYTRHLQKCKSTQICPPATYSCRCGNETEDKAVHSTHVNFCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZX2</accession>
    <name>A0AAE0TZX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_501483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041933843" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1892"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1918"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1953"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1985"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2026"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2070"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2107"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2138"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2178"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2218"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2261"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="68"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1638"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1796"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1664"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1801"/>
            <end position="1814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2289" mass="254870" checksum="078D0A21EB10E5F2" modified="2024-05-29" version="1">MIPGVLTQTFFTFVFFAVFSLSLPHLPEYEAYNLNQNQSATNPMQYWGEWADHEFHHSPENWRMPFYSLFLDRFVNGDPSNDNSNGTAFEVDILSTQLRVGGDISGLIDSLDYLQGMGIKALYVAGSPFINQPWSADSFSPLDLTLLDQHFGTIATWRRAIDEIHRRGMYIVLENTISTMGDLIGFEGYLNTTTPFSFTEHKAIWKSSRRYWDFPIGDDTVSDCQYPRFWDERGEKVGSNVTSLMTSCLSSDFDQYGDKQLSKFGFVQDRLREWRPSVLDKIKLFSCMTIASLDIDGFRIDKALTITVDAQAEWSDHIRDCARRYNKTNFFIPGEIVGGNALGALYFGRGKEPDMALDTTNTSLYIRTSHALDSACFHYSAYRALTRFLGIDGVYGAEMDTRVNWAEGWEDMLQTTDFINANNGKFDPRHMFGVSNQDKYLVGAFITSLLLPGIPIINWGEEQAFYVLENIAGNYLYGRQPMTSTVSWELHGCYKVGSEKYFNFPLDAALYGCDDPNVSLDHRDPSHPVRGIVKRFLELRTTYPVLNDGFEMHQLSNHTHWIFLPGSEGTGTELGLWSNVRMRHAGLQDFSSVDHGNDMVWLLFGNEDTATSYSFNCSGITALISPFASGSTVKNLFYPYEEYTLEVSTQSLGAGSPGLFHGCLSRLQQFPAWGFKAFVVKDSWVNPAPTITKFLPGHDYRLESSQNGSTSVEIQLQFSREMDCESVFNSIEITSNTQNGSTAALIKDSLKCWVLDHDQNPPRFAGEVPSVWALAVTIFPIPDGIHRITVRNATDSTKTHTTGSVDHFLLRVGKLSNPMVFPRHANYSQELLYSQGSDIFVRHNAAGATQFRCSQSWSSSWTDWQNYTGMDFKLPPKNWTGTKLQEWSGEHVACQYYSNLAGSSHHQQEGDLDSSYLPRRFPHLFINGHFNAFGFDSGIPNQMLQRSGNGTWSIDLMAEWPTALQFNVWGLNPDGLPDQTWIFGDVNFDFVLDRLPPGSLRQNVVNITMSPPSPFVGWRFTIDDATMKYGVFPAGSRARQITIFSLLWAVPILSGCVVVFIFTGSFYKVKHNLSGAAKDSGLSEKFRQAFDLKVRNKAALSSRQPPNNGDNRPGTSHTTTQGTGGEILGMELGAPRKKVLIATMEYDIEDWAIKIKIGGLGVMAQLMGKALGHLDIIWVVPCVGELPSDYPVDQPAEPMLITIFGSQYSVNVQYHQLRNITYVLLDAPVFRLQSPSRPYPDRMDDLDSAIYYSAWNQCIADAIRRFNPAIYHVNDFHGALAPLYLLPRVIPCCLSLHNAEFQGMWGLGTRDEKKEVCSVFNLDQKVVERFVQFGEVFNLLHAGASYLREFQSGFGAVGVSKKYGKRSFARYPIFWGLSKIGSLPNPDPSDTGEWSLDMEAASQAQEVEVDAAFEAGRGELRKQAQLWAGIDQRADAELFVFVGRWSQQKGVDLIADCFPSILEKYPNTQLIAVGPVIDLYGKLAAIKLQRLMEQYPGRVYSKPEFTQLPPYIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGARVGGLGNMPGWYYTVESTSAKHLISQFKEAIQGALSSNSTTRAKMRAASAKQRFPVARWVEEIEALHSTSILKSQKYRDKPAHLPLTSLSRLTLSSRPPSPGLSDVHDSRPITPRSFLSPGSSAATNTNHDLGAWPLVPPDRKRLSTISISSITKGRTDFALQKVDPFFTDADGEYTEEFQRKLAQLDAKNSETDLCIEQHLVRSEKKWFDDYKSIKFGLGTSSRNSSRLNLTELSPAVAVPDTSRFLDVPTRSHSPYSPSISSSSIYSEDGQDEEPEALPSPFISTFETDENPVPNLAFASPLQKFMLRKIFDWPVYTLILAFGQILAANSYQISLLNGEQGQTASMLYTIASIYAGTSVLWWIAFRQFKSVWVLSTPFAVYGAAFVFAGCAPFSSSVFARGWLQNIGSGFYAAASSSGSMYFALNFGDEGGAPVKTWVIRACAVQGIQQIYISGLWYWGSLLAGYDNNGIPMARATNTIISAVCLPVAGFLFLLSIITYFGLPEYYRQTPGSIPSFFKSIFRRKLILCFLVSVIVQNYWLSSVYGRSWRFLWTTSHASAWQILILVVFFFGIVWVALFIQLAHFSREHSWLFPVLAIGLGAPRWAQIFWAVSGVGTSLPWAFGGSGGSVSIAGGALVARALWLWLGVLDALQGTGVGMMLLMTTTRIHNNFALVAAQVLGSIATAVGRATAPDAVGPGPVFPNLALSLDGLGNAWFWVCLIMQIGICVAFGTFFRKEQLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZY4</accession>
    <name>A0AAE0TZY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZY4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="256" mass="28089" checksum="FCDF9C313EAFCA96" modified="2024-05-29" version="1">MNPSQYLPNRYAMNPYGQQFNPSQQQFQPYPGQIPSGQLMSFPPYGSSQGSPGMQMQQGQQLPPGAMWASGFPTGPIIEDLCAPNPMSMQGGSPPINSMPARMSMASMHPSSMPQVQDVFGLRQPAYGTYPQGISPHQAAQMQQAQRQQQRMMGPYPPTSGFGAQQQQLQLQQQQQQHHQQQQQQQVQRAVQQQQQQQQQHMDSSSLMPRSRIDVATGFPAAVSPNGLTQMSSPGGNPQAGLPMTPENGYSSFMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U028</accession>
    <name>A0AAE0U028_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_544077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U028"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="636" mass="68859" checksum="7BED005A8376575A" modified="2024-05-29" version="1">MANRSLSPVSSPETLSNTLLPRPSTESTAELLFLSVAASVTILVLARASRAGSGFVQLGTPPSFLADNPDLFRAVWLQGLHYTTLPAFLMTLYRTGWDAVVEALAERQPFVELKRKDGGGGTAEKTILLDYRAESLLTAPYVALRNKHYFLAACLATSVLLALFTVPGTAFLFTPQMSSFAYPVPVRFTSQLNMSSVFQPPPDGPSVRVPLRWAVASSLMNAPPLPWTDGRNAFQVFDPLLPGGLPPQVSGGDDDTGGQSFLSVDNGTMYLTQSDCVVLREGVDFRFEIWTPPIPGLGAVSVHFDGSDRRCSFQYDLVIKIGESYGVKFTPMCVKAFLRNGCGGGDAGRSRFLLFAANYTGDRTSTHSVSNVSVVSCKPRYWSVPVLVNATIAWSFQNKTPPPPPPPPPPPPRINGFQADWSRAVEELGDATTFLEAALLAPVAVDDPMMKIQVTGEFASGVFDIADSKSRDSPLDSELLRHSMTDLFEKAYAALAATVFSETLPQPITGTTGLATVDQTRLIVVEPVAYFIVACLMLVALLLVGIGVAVCKQEAALFEEPVGLLAAVGIAQRSHHLTKAVEKLGQEQGFAGQFQRSALKSTGFNLKGTRWWFNPIEGHIVETTRDWDGYITDRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U033</accession>
    <name>A0AAE0U033_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_473365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U033"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042160879" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15854" checksum="9A120BF5BB58EE3E" modified="2024-05-29" version="1">MVQLNALVATFAAILSMASASPVSARQDDTLYPEPITIGRLSIPHGYVLYAYTPTKTTLQQACSDSPSRTMVQSVQTGRPDRPLCNNPFSLDGYSGLEFLCADGTGPAASQVTAIATNGTQTHLCTNVPLTVYPLYCGGGASISQQYICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0N3</accession>
    <name>A0AAE0U0N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="582" mass="67686" checksum="9C8E4ACB59D3B3A7" modified="2024-05-29" version="1">MEEVKPAFKGEPKRMPQDENRPPKRPEKIPIDDTENKAGAIPMEKMRKHYNHEVKRTERRASDSFVVIEIDSAEVKMGQERERSERKQDQRSAMCSNQWPAGYWPQSPPQFQSHHSHFPPAPPPHAYHSRDFASRLVQSSDDIDVDRRTAPRGGKEDQSFRQEIERLRGQLRDANSRAEQAERAAEELQKRLRSRSQEAKPNNGRSTDAIESLRSENKDLRAELDDARSHIFSLQPYRRDLTPEEVGRDFDDLVNNITDWVTKFMEPILDDDSKADEVLTHSRKRPAEAQRLRKCITLHGDLINGCQFPDTDIDLIVAIVMRFLLDNIFQKTLFGVMPQAVELINFIEASMRNNVEPKRDLFALRTWQAEALNALICTPEYRVGCTERTRELTIELATMFKPFRKEKDHSQFCCAWQDNVVIPAVRLNEKLLISTHHFYLDLNPFMVWNSSQTLETSPDFVNNLHRLRCENILQNRKPFNVDRLDPRPDEEELHKDLLHVVNVVPALYMRQIGRGDVIKAPMVIRKQQVLVAWGSQERKEKFMENSQRTLIHRLYYTPLSREKQERGFDGGGLRAALGAWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U121</accession>
    <name>A0AAE0U121_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_148561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U121"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="93"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3387083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="484" mass="52396" checksum="F42EBF4A1ED89842" modified="2024-05-29" version="1">MADSDGEFVGDVSDDELADHGAGGAHGTRSKGKDGAKGKSGNRKARWEDIQRSWEEVGEAADGSISLGALLEAEKRRRLLRDTTPLQRGIIRHLMLVLDMSFAMADKDLLPTRYLLTITYAVEFVREYFEQNPISQMGIVGMRDGIAVRVSDMSGNPAEHIERLRVWAEEQEPQGNPSLQNALEMCRGALFHTPTHGTREVLIIYGALLSSDPGDIHDTITSLIADHIRVSVVGLSAQVAICKELCSRTNDGDEGNYAVALHEQHFRELFLAVTTPPVTRTAEQNNASLLMMGFPSRVLASKDHVSLCACHNRPSREGYSCTRCRTKVCRLPAECPVCGLTLILSTHLARSYHHLFPLRGWVEVPWAEAARSTSCFSCQAAFPAVPSKASRLKGKGSSIGVGGEDGQVVPPLLPDATKGVSESGRYACQVCGNHFCIDCDVYAHEIIHNCPGCQSDTRALNASMGEGPDVAAAIANGSAMEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1X2</accession>
    <name>A0AAE0U1X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_159952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1X2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1097" mass="119193" checksum="CBD839E665F24BFC" modified="2024-05-29" version="1">MAVFCCCTAPRSSKAWSSLHKAHPVLPTPPPPVRLPGPLTLNPVSPNTSPESLSSLRVSVPASIAPIEPVELGMLVVDDSESEEEVDPSVPGKNSSTLQLVRTRIRRHLSQDSLSRRKARSAIGCSQEEIDRRAELKRLMHKRIQEELRNEGGQDTTQSEVSSSNRPRGTSIDNLPGGGPRDNLEFFVSEDDSNLGKQCVTNAGSTNNSQGKNLLPSFSADDSPARRTSCPESHPQSVIQALVRERSSLPLMPASPNLRPRRLPSTHDTSSLGSWRLSYSGSQLDEFLGYSGNGDSSNETGSVHKLQASPKKLPIPGHSHSLSRSHSSPARHGTPRKETSPAIDQSPLSTWLRSQGLRSRSQSPSISCLRTSEQGLEQEGSVKEAEVVYIRRWSSVQNCAVTESDITRPEVVHLYDMDIHRQLVTQALTTPVDSRNHSVGSHSHPVDSRSHPGSERHSSLKSSGSRRSSSSAKVGAPKAEYQKTTSGLGGEYVEVGAGSQIADARTTNSSSVYPSTMNSPSPSPGTCSPLLPDQSARRRVSSLGFQWLDNSGNPHLSNRSQMTIEESPSSGPVCTQGKTDCHLPLSETPGKTRRAPPPEISEKSLGLFHLGHGAPAIIAGRFRKDANPPSTPSPDSTKPSLLARLHLTIPRRARLAPRGFDGSSPSSEEHHIMSPISKTGLVVSTPTRSRSRGYETDRLSPYSQDPSGLSECEDSTAELWQRAVREEAKARKESSTRHSGHRSRRLSFPEDTYKKHKDGESALSLYGSYVHASSKFPDAWPRCPDAWAKFPLYSREERNGPAGCADEVAPKDFARRSVVSCKGMPEYSSEPSALPAEQTPKYGTQSIPGRFSRAVKSGFSKLVPPRSSPSRESPKSTRSHRKGGEKNKGNLEYPEFELLPKEGGYQELKALEHEIQHLKGTPQLRCPIPLQDIPSDRTKVTLSAKMATILHTDGASETVQEKVSAQLLLTPATPVSVIKHRRESTTTTDKFATPLSSMSINNDSSSYHSYPQSRPRSRAMATSSEVVAGTDCDIVSVKSDTTPMQIRPATAFGPGSEFGVPGSKFWVDTSKTGKCNTWSGRSKTHPPSTLEGVERID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3L3</accession>
    <name>A0AAE0U3L3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_492483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3L3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="524" mass="57900" checksum="BD372D78F17E8FA6" modified="2024-05-29" version="1">MTSLTVYAAAALVLGSVYFLFVKKPKSQLPLPPGPPTLPILGNVHQAPKSHPWLQYFEWNKTYGPVVHLNMAGQPVIVLGTSKAAHDLLAKKGATFSDRPHFVVAYELALQGMHMLLRPYDERFKLHQRLEAPLLSEKAAKAYLAIEGLESKQLLFDLLKDSGRTINPHGHLERMTASIIYSLFYGHRVRTENDAILVQAHAVNHEFGQLVQVGKYLVDSFPVLNKLPAFLAPWKAEAAAHWKNQCSLHVGNLERGLATPSWNVAKQMQKAVDTQGIAMSVEELALNVGIMADAALDATSETLSWFVLACITEGNRGGNWIAKAQKDLDTVVGRYRLPSLDDQPALPYIEAIVEELLRWRPAGAAGVPHFTKIESTYEGFRIPANSVVIANHWSITREEAVFGPDVEAFVPERWLGDGKHLPTAGFGYGRRICPGRHIARNVLWLNVSRILWAFNVEPELTKGGEPVKVDTKGADGLVTHPLPFKACFTARGDWVGDIVTTGCDTWSVNCDEMLDDIQSTGVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3Q5</accession>
    <name>A0AAE0U3Q5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_389779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3Q5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="504" mass="56003" checksum="9C0A78A9C2D83F0D" modified="2024-05-29" version="1">MQHVSAFGYPTPPASPAFEQQCAIQGQHSSVNQYSCPPRFPPVAPEERLGSFITGSLQLTSILGTGAYGVVYSAVDIKDNVRYAVKFLSKFNADGTPLDRRQVAFQTQEIRLHYLASAHPNVVSMLKIIDNPDCIYVILEYCPEGDLFYNITECGQYVGKDELAKSVFLQILDAVEHCHSLGIYHRDLKPENILVSDRGETVKLADFGLATSSDRSEDYGCGSTFYMSPECLDHSSRRPFYYCAPNDVWSLGVILVNLTCGRNPWKQASNEDSTYRAYAESQEFLKTILPLSDELNDILGRIFTRNPDQRITLPELRARILSCSRFTEQPAPLLPSPPASPEHTPEYVDCEESIIDNEFDSDAPLSPASSGSMSDGGSTCSSDEGSLTSTCSSIEDLDDDDFLDDLPEAKTPPPPASQGEPSIYEPEEPRVLAYSQEYLHPYAATTQELIQAMPVPVLPACGPKFHLQQYVWDMLKYAQPAPQLHHPVPFHHQVPLFTHLQGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3X6</accession>
    <name>A0AAE0U3X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_103002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3X6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="67"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="462" mass="51648" checksum="4C0477E9A0A17A70" modified="2024-05-29" version="1">MSLNADKIVNLDFYALPAGVQKFLLAGSAATPPQGVTANFSNPSNQNALGTTVIVTGVVLVATTGLVRLYSRFLTKTWKIEDLLGLIAFMCYVVMLYCIVTLMRLVGFFVDQWNVRLQTFVDCAVVVYIYPMVYSASMLFAKNAILFEWSRIFVPAGTRNAFFWFTRVLIVANTMLYFAGIIAGVFMCKPIAKSWDFFIHGECLDRRQVHGSMVCFNLAIDLFILILPQKVIWSLQMTRSRRLGVSIIFSIGLMGLACAAGHTYSNMLGYGYKGSNTTMMVSNTFLWSFSEVSCTLMVFFVPAMPKVFRSTDHGFFSKIASNLRSWGRGSSSRLRTPKESKASDTQASWGNVYTGHQASFGGGTQMAAETPSEWAYPVASHTSDPAMSQTDVELVHSKAVELDYQNPIIQPPWNAGIVKTTEFRRNEEEREAAPYQPPQELGVGIDRHRPWMDRNWDGSPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U457</accession>
    <name>A0AAE0U457_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_556995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U457"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="507" mass="56331" checksum="301148F6090B1580" modified="2024-05-29" version="1">MSAHEQGHRALKAQSGGINKTRDYHVICFSARPSKAQPGKKRTKFTPHRQQEVAAVRRRGACLRCRLLKITCSGDDPCKTCLDLASKKQENKVLSFTFCVRTKFGDVDIFAQGIEQTDTTAQKAALLDARNTALEFAFNWSIPDLVGIVSNWFEHPADVSLSLAGTFSSRQMSDLLRPHLDDQITSQHRMLVYASTLAYVHSDYGLREAWEGQLGQSDLHQVAYVAGHNLIRELDRILSPTWIAKASKETVEALFLLTFGTMLAIGYSQPMSIGQDIPPSTLWIAMQGHLSQMLAHYLVFLGAKLGICFNTETEKQITSSPETKWKRRGRFTWKTKIFIEEETVYEENLCPSWDPNKPVLIIPNIQHDTALLKLSDAGLGSYGNACPGNLLGFINSLPQDQPVDIEHGDGSRNPQRDMTVDRYCFRADPEPPMSSMSQPSQLGVRYLEVVKRGNQTRVRVQNGPEGSSPIDVDFGIFFGAEQTSCSGEPSPGNICVPFGPAEARLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4J0</accession>
    <name>A0AAE0U4J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_446494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4J0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="550"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="653"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="783" mass="86217" checksum="521ABFA4040C5C44" modified="2024-05-29" version="1">MSTGLHDNRYDSIHWVKDAAREQLRRKSRRKRNAGLFDTGRFDWRHRLWESYDAAQGWIVVTIIGAAIGVNAAFINIVTEWLADIKLGHCTTGFYLNENFCCWGEDNGCADWHRWTGFEPVNYLIYILYAIIFALTSATLVKSYAPYAAGSGISEIKCIIAGFVMKGFLGRWTLVIKSIALPLAIGSGLSVGKEGPSVHYAVCTGNVISRLFDKYRRNASKTREILSACAAAGVAVAFGSPIGGVLFSLEEMSSHFPLKTMWRSYFCALVATAVLAAMNPFRTGQLVMFQVRYDRSWHFFEVVFYIIIGIFGGLYGAFVMKWNLKAQAFRKKYLTKYAILEATLLAAATAIVCYPNVFLRIDMTESMEILFLECEGGEDYHGLCEKEHRVGNVISLLVATVIRVFFVIISYGCKVPAGIFVPSMAIGASFGRSVGIIVQALYEANPGSVFFSSCKPDVPCITPGTYAFLGAAAALSGIMHITVSVVVIMFELTGALTYILPTMIVVGVTKAVSELFGKGGIADRMIWFSGFPFLDNKEDHNFGVPVSQAMIPDVISIPTTGMTIKAVERLLSNDSYQGFPIVEDETSQILVGYIGRTELQYAVDRIKSERSPSPLAGCTFAASPGGPDTPISRTASASFDSGSSTSVDFSPYVDTTPVTVHPRLPLETVMELFRKIGPRVILIEYRGRLMGLVTVKDCLRYQFKAEAAENPRNGDPHPEEEGQERLWGFIQRAAGWVSDKVSSASGGRIRLRDSLERRRGAPDSILDGTEELDEEGVELTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4T5</accession>
    <name>A0AAE0U4T5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_116966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4T5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="235" mass="25586" checksum="3FA82C485B168EE6" modified="2024-05-29" version="1">MVNQTLAPYKADFLRASIEGGILKFGSFELKSKRISPYFFNAGNFYTGKLLREIGVAFAKTIIDAHKSGVLEFDIIFGPAYKGIPLATATTDKLAQLKPETYDQLCYSFDRKEAKDHGEGGNIVGAPLKGKRVLIVDDVVTAGTAKREAIDKIRREGGIVAGIVVALDRQEKLPAADGDDSKPNSSAIGELRKEYGIPIISILTLDDIIEGLKALGSADDVKRTEEYRAKYRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4Z9</accession>
    <name>A0AAE0U4Z9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_121494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4Z9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="17487" checksum="F7FF195DE27D64D7" modified="2024-05-29" version="1">MGEKGCTHLRGPIPVLQKTHLGDSRWCRGSGGCLIRNQSFRKCTSQPDARSAIEGRLRMYNTNLNGTLGSTRAGTAHNGTRLFSNMPQDKAAIETKTTPPATSTASTLSDSSFKKWVAVMERQNKGWQDFVLKLVALGFAAMLLAFIIHDFFASFYNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U560</accession>
    <name>A0AAE0U560_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_557871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U560"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041988062" evidence="2">
        <location>
            <begin position="25"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="792" mass="79183" checksum="C6AA5B385EEFFFD2" modified="2024-05-29" version="1">MFPGRQVLLSAAVLSGFALDTVSGGLVGHRDVSLNNTLQTTSAESVASALSLSSAVPSLAAPVQLTVSVASAPTASPASVDVVVVTKSGGSLGAAVIRTASPPGSDDDYVYPGVYDSGGTLTTDVNAPTRTVVPTRISVVPNPKSPILGPPPMDMPVEIPESTFNFEPVASSVATAPPANPGWTFGPGEAGTLAPATTTTAASTTAAAAGAVTTTPPRVPPLLPPKISSISIFVSSSGQIGLGDTSSPSPLSGTDLAWQAGPSSGGSGQSFSLSGSPSRTTLVTSTRYSNQTWISSAPYSSSITYCQASDSALTVFTSWSIVHTSTITWYGNPSDYTQPFAPIETPTPPAPCVEPLSPPRMTISVCSSTGTNSKYVTCTVTTSTASFGYGIQTSETVRPLPTNTITFLTTDKNPAVIFKTIETPNYGVTEEPKTRDNHASPTSGPGPITTPAYNSPVSSLAAHAAPPTSPVTVVVQPTAVVINGNTITDNPIVKTQVVVISSQTFTIDPTRVIGAGATVDRPAATGGYYTPLPPPPPTTTSLAGLAVVVSSSAAVIAGTTFKIEDKPATVTVSGQTFTIGPSGIAAAGQTLAIPAASPSPTEVVVVGGELITAIGQSVVVIKGTTITYGNSGASTATVIDQDTITLGPGGITAHDTTIGGTTAKSTETQFAVVGGATITKIGPSVVVINNVTYTVGPGTGTTTTVIGNETITIQPSGVSVSTLSFDFPFGPGSGPTTTIVPSAAGAASSSQPTVTSTSAAAVQDAAADVRPNRAMLIFSALLSIAIGVMALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U748</accession>
    <name>A0AAE0U748_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_8220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U748"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="277" mass="29590" checksum="A3EA12EEAF633659" modified="2024-05-29" version="1">MASQGESSDNTSSVRTTVVVEAEPQQPCMEEGDSTSAAVKSGQPEVDSQIQAYVRPKAFRKLSNASSIISEIFHHPDVAEDKIRGKIKRDNDRETSRDLIDFLNNTPPPTGNNLSVPAAGEGNPGETEKTKRPIFWTLRKKLKASKATKVGGPTTAGGLKRPTSAIPGRTSNGKPYLAIVPHEYMGGLNATPGAVFFPELSNLGRSVATFPNQVPEIHKPVNDSAIPASPPIHNGQIVGGSLLSPDQNLESWSDDASREAQSVHPRIADTSDLALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7P3</accession>
    <name>A0AAE0U7P3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_444252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7P3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="246" mass="26606" checksum="3EC5472FCDF93C87" modified="2024-05-29" version="1">MATAQPLYVLPGDTIDPSLIPTHKKLPLRLGPGLRHIPPSAIVPTVAGQLVADHKKNSMWVEYNGGRYIPAPNDLVIGQIQRSAADFYFMNLTPFTSNATLPQLAFEGATKKNRPQLASGALVYARVVLANRHMDPELECVSSSTGKAEGLGPLTGGMAFDVSLGLARRLLMARSREEGKVEILELLGAEGLAFETAVGRNGKVWVGSDSAKTIILVGRALRETDDGKLDVDQQKKLAKRLIREMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8M6</accession>
    <name>A0AAE0U8M6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_518148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8M6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="329" mass="35841" checksum="4896A8C033A67771" modified="2024-05-29" version="1">MAVLATVSDEATNFSLALCHAYPFCPEIYFWFELALWAVDSDTANSSPFPADGQDQTLEMESWPIVEGIPHVDGFFAALFHPALQQQQHDFDLNMTQMTPEQALHNNTRLLRGIVGLYRRYTSQVANREMRTTALPSSPSSSSGIDGTQTHTIQGAWSNARRAIVKQALTSKIIIQVLLGIMCASGVGAYYILRWGCGRGGGDKGSSGTNVFLRNPCSIAGTASLLAGSVMGRCNDVDGVATGTASGREDKGQEEEKEENVAAWAEKRLKSWESCVFTLGRWGDRGLASILHHLRLPLLLPLLKTWLPVMLLLGQKIGPTRRHHTAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8S4</accession>
    <name>A0AAE0U8S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insecticide toxin TcdB middle/N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_533430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8S4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022045">
        <property type="entry name" value="TcdB_toxin_mid/N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12256">
        <property type="entry name" value="TcdB_toxin_midN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insecticide toxin TcdB middle/N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="275" mass="30907" checksum="458937684248F6A8" modified="2024-05-29" version="1">MKYSYHDGYFDPYEREFCGFGMVETSQRELLHLAPVAEPSTTTTVPCRPYKTPMHYTKRWYHSGAAGARLVPSDNFGEVRIKTSLLGDGGWSMPANIRRKAFRALRDPATPSWSQNYKYQSSSLLKPSRTGNRLTATELPGKSSTPYFYDKSGNMTAMPGFAHLEWDAFGRLRSVSRQVVNEGKQQQSRAAPETTLFVYDMDDVRVRNVTDAFSSSRKMKETLYLVSTVEQHSTSGGMYHCARGTTCRGWTSGPRQTPSTRQTAQTSMRTAATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Y3</accession>
    <name>A0AAE0U8Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Y3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="141" mass="15473" checksum="C3440732A2B646FB" modified="2024-05-29" version="1">MTLSSLRTLTITQKYISMAERYEIVFVFSPFAGPTIELRNFPKAGGVGTDDDYEDTNNSMRFIVTNPPTSGPLLLLPDLSTVPSTLRTVPFPPHSTPAIVNHSFLFHRQTPSGKSTGWVSPNPKTASLQTCRTTRSRSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JY07</accession>
    <name>A0AAE0JY07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JY07"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="384" mass="42777" checksum="01C3F0F6FABD23F1" modified="2024-05-29" version="1">MRDESAGVMIELEANVNAFRQFFQIHSSSRIIFSCHYKAGASSYRAHARQAGYKHVHGGSAASFCFGVVNGVPQNGHHYTRRHIICRIRACVSRIFDSSAFPEFLEQSASSREPYAQGRRLLYISSLPLPNCRGPASWTTRSFSTSSRTLDCSMVSTVANTPRPPPAPSTGSRLRPSHPDGPTTQDDWSGGTKGKQPRLQDLTNQEDDAAATPYRAQTPNGNKQAYGFNQSNNQFDQPSPPFGRVIRSKSALPSSDTFEPAQEHHEAPDTQFAMLAANSIEETSPLRTKFPSHNKLMSYVYADHLKRAWPGRQRKDRSRSPIDEHPPPVEPDRSTFESDSTPTAFHGDTSNPMDLSHVIEPQAKDVDPMMSTRRRNRHGLEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0P7</accession>
    <name>A0AAE0K0P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_536029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3367898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="184" mass="21241" checksum="C42B96A5F478B7FA" modified="2024-05-29" version="1" fragment="single">RYLEVSEFFYRSVTFTFSTFQELHAFVDRVPAVPLSRVRSMAFIAHMPPMNPQACQRFLDGEYFVTEAGENDALLFTRVPNLEVLHVTFFPSIILAMSQKLYEVVEPLRQLPEKLDITLRIPRMEYGNTSVVSLPISSRLPEGEGRGRFTIKRPSMRANDRVVMGDCREHMFAGPGFPYDVMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K164</accession>
    <name>A0AAE0K164_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_528520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K164"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="101" mass="10908" checksum="79A99D3CBE292EA5" modified="2024-05-29" version="1">MNSKSRASAPAPLKLSTSRSMTSPVFTSPRSADSTASRSFSEDDYAGLISSPPNSRKASGSNKAKSPHNINVHSYCGRHSDQYLFGGHSFGELWRSVTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K188</accession>
    <name>A0AAE0K188_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_71605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K188"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27187" checksum="963AADBC37AA4EBD" modified="2024-05-29" version="1">MILREKTESERIPIAFVAHDLGGIIVKKALVIARNITMYHSISWECTQLVFFGTPHRVSNSSSWEDLLSNALLASPLPSHIKGSMATRLRSLSTFLENLSARFISQHARRCIINVHQNIDGTNDTDLVINPDSATLGLVHETIVPGASTHHGICKFSPDGPVSAAILSAFEAETKSEYRTFLSRLFDVSPSQYQTINKTCICQSQVFIFKKAMKTGWYRLHHASLRRPGTEALEKAPMHALCSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2D2</accession>
    <name>A0AAE0K2D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_488352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2D2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="33065" checksum="31AACE80EC7E8176" modified="2024-05-29" version="1">MSVSATHPWSTLNIPIDHKAAVEGSHICIHSNVFFRSKSEFNDLSQLWWRLYHAGFNFFSVPANNQNNCAMEHFVQTLPRDKVVIQMEYDGYHYDEDGHPESGDPDVPRNELTQKLGQCRAVGFVDIFLVRGPLDHPETFSQLAAGLARCVGDGLADSVGVSNFQDPGHVQQLYDALNQEGVQLSTFQGDLNNFRRRQPRCQRDGRVIFQSIAQSSGNRTELRGHLGRGQTFHALCRIANRRQVSALTVALNYMVVKGFVPVVDVRTDDEVEQVIEATGWRLSQREIEEIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2U8</accession>
    <name>A0AAE0K2U8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_497690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2U8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="593" mass="64982" checksum="D13C2BFC235248CA" modified="2024-05-29" version="1">MALRFTNMPAEKLPLPPPGVHPREVIANTILREYLGKKSGPNGGHLAILVDKWRDDSGVTDSGPYTGKVRIVGAGAAGLYIAMTLNFLGIDFDIVEASDNVGGRCATKSFKDVGPDCAHNYYDMGATRIPNIDSMNSTLNLIRNPFLLNIKNKLVDYVYRVYTVDSEGVTTYYEPFCYWYQNEAKFNADKYEAAIGDVLALFQQPIDKTNPLVQPYFTGGNDKYSTRDYLMMGPMKLPIQNLTYAETKAGELADSYNFNDFIAASKKNWFRVEGGMSVVTDTMAACVKSTEWPPKTGGPSIDVTLSTPVLAMSLTPDGESIQVTTGGKALSTNSYDMVFNTTALGPLQHMDLSGLHLGRDILDGIRVLSYDRATKVAVKFNTRCDLPLGYTVYRSWDDGDGTNVLIVSYTWAQDAARMAALVPDYTNPSTPAPKFTDPIAALCLEGLVKLWQGKKGAPTLSELQGYYATHHAWAWSHDPYTCGAFALFGPGQFENVWPPLKLLHADSRLAICGEASSVYHAGISGALDSAYFAVTTFLAERATKFPDMIDKAKKLVDSAFNLGPKPFENGGRILHPERDDVLARWCAPVSAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2Y8</accession>
    <name>A0AAE0K2Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2Y8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042071937" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="154" mass="16678" checksum="798B8A9C3344D880" modified="2024-05-29" version="1">MMGIANVVLFLLCTFGARAGDPLGVVPLPALSGSTSLIGLLSAAPTPSTATHPDGPDRIFADFPGIEFDVKVEKPAKVDICCKEGCKYCFDQSCPCERFDDTLRPIQQYNVCCPGRIVGRDENGTMVGAYHYTESGKVETLFFLNLKKFPHVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5N1</accession>
    <name>A0AAE0K5N1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_454716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5N1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="414" mass="45810" checksum="9CB91BC1AE17AE89" modified="2024-05-29" version="1">MGDAVVSGASRMGLTLQGYDQVISLSQTNINQTLKRYFNIDSAALASFEAVLGPETDPDYTLIGNIQPPTIELIDADKADKADQAIYTIEFKKDSWYTYWGADPNNRRGAPEIETVSRRLTLAFFVNFGLEKCKRMPAELQETVRKTGSYSIDQLVIIFGTAALIEFNWTDSRFPGLDDLTAQLDAKTKMSDFISKWLMSLKTAAPGKSHNVLGYSVKLDVEGNPSREQLLAKIGNVPPSFPLTNVQFQTIANKLSAGANGALKIPTMHSSSRKCVASPASPLRGRCRKSISNGAPDHVEHHFLREFVGKLVEPIHKECSAFADTLAKRQTWDAEYRINRVKNNVKFLGTWVDGLWLAVGNQWVLESTATSSHAEIPWEDNNRSFTVQVIVQANMTSALKPVPGTGNFHIKQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5N8</accession>
    <name>A0AAE0K5N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_303061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5N8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="53"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3369815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="406" mass="45309" checksum="81B2D4652AA87A5D" modified="2024-05-29" version="1">MTPLLSERDITFSPYMRPEELAKYDFSDKSTLAPAIWRVNLVFIVLVGIVISLRIFTRAYMTKHYFVDDVLAVFAAVFTLVSASTALVATQYGLGQHVWNLPLPLSSILDNITHCVKLLYVAHIFYAAASAFTKLSIITSYLRIFPHETLRRILYGTAVMVAGIGVSAIFATIFQCKPIEAAWDYSVPDGQCFPFLDFLYANAAISIATDFILVAAPLPYFWSLNLPLRQRVVICILFGVGFIAFAASVVRIVSLRDMQGIDVTYFLVSPLNWTVIECSLGIICVSIPPMRPLFSRIAPEFLTNYVTRFTTTSGTANNTGAGARSRAIDHNSQVMSQPRSYRDIMDEQNREMDRQLMKFEMAEHNRRLEKGEELVTSTSDCVSSTASDLSIHGEKAYEHTGGRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5S6</accession>
    <name>A0AAE0K5S6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_564718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5S6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="43083" checksum="3A2439CFB561CB15" modified="2024-05-29" version="1">MAVKLTPLAFQSQDIALPEWISLLTLCLAPVFAHVVAGVPTPTHLTPKKLRWHDMLAHYNPASIAWRYAAIADRRLRARDWTCADVAAANALFWTAEGWNGSETMVAASAPYVIHLPEKPRATFLSWDTVKTLVVTVQGFQVLYVCFVVSTRLKTMPTSFPVNELFFPVAVLGLQRLWAALWLTDDFAYTPRDISQPSADVGPLHSTANAPLKMLPTNRYHPPSFWPSRIFRALYVVPLLATWASCVEAFMPRSAGSPPSSPTPATVFMCLAAGLIYLPLTIAIFTYYTARHGCRSTIIPCIGSTWYKILTMLNFVAALAVMVVSAMETRRAPCGKYTTTGLESDFRICPGLVDVAPGGVFVLGSRVGFNNSTTAVQQEFQISNFTGVCQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5W8</accession>
    <name>A0AAE0K5W8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTAFII28-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_318919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5W8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="170"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3370641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="333" mass="35334" checksum="F7C33E24A674D328" modified="2024-05-29" version="1">MTSKKRPTDGGGGTPSSASKRRKPSAISTTSGLGSAHPLRQTSFPPDEAGTPYDMRSPSIDFDNMSLVSGSQVSIAAPPKGKKRGRKSKAEKTRETTPSVAGGSFTKAASGVSDGGTGSGKGGGGKSSARGGAGDGDDADADDDGPTEVAATADIQTKEQKEEEHRVRGMLMSAFSPEQFDRYEHWRAGNLGKAGVRRLINATISQSVAENIVIGVRSIAKVFIGDIIEGARRVQTEWIEKTGEKQTDLPTPPPSAKASPNPAGEGQETQPDKSVDMQFGPGPLRPDHLREAMRRYKRSLEGGGVGMQAIWHQHQQNGIERFPSRTGGRRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K662</accession>
    <name>A0AAE0K662_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_315194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K662"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="221" mass="24709" checksum="9F754331A426249E" modified="2024-05-29" version="1">MDGHQGRQKVTIQTMNAPPAADPVQYTISQDQGAGNSAQAESNYALLIRKDFDLASLAAGENEPRRTNTSTHALQDYQMQLMLLEQQNKKRLMMARQGFETEVKATSDEETDEETAEEIDEKFDSGQRTVKEVDEEPNEIESHGESSPQVGKKRNYDGFGDDLDEPVVEGRTLLIEEHATATGEKETNFKRVKSSKDDPSTMMSPARKITVSHFTFFSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K712</accession>
    <name>A0AAE0K712_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_552783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K712"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3370651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="891" mass="96178" checksum="15CF27E34B5DD231" modified="2024-05-29" version="1" fragment="single">FHPSGASYTVYKNAITDCGAKGDGVTDDTKVIQDCIAAQNRCGGESLTCASTSVMPLVIYFPPGNYLVSSSIEMYFQTLLIGDPLDRPRIIAAKSFQGLGVLSSDFYIPGSGGKTWYINQSNFFRQLRNFIIDIRNCPDNPKNTPPPGPAALHWQVAQATSIQNVEIYMKESSRGHVGIFMENGSGGLLTGITFHGGYVGLRAGNQQFTIKNLTFDKCRTAIQAIWDWTFLWTNIKITGADIGIDLINQDLKNERKPQQTFAYLLIDSTISAKTGIRSNPFMATDGYAQITLDNVNFAGSETAIKETTGATVLAGAPKVDSWMWGIVASQESPTGRQVKGEAAKPVRNRPGGLLGGPNGGYFDKAKPQYENVPVGSFKNALSNGCRGDGAADDTACLQNLFGSPGYVFLPAGVYRVTDTVKIVSGVKLVGEAWSAITASGDKFKDMSKPRVMIQVGEKGQTGDVEISDILFQVEGPMAGAILVEWNIRASSPGSAGMWDAHFRIGGNAGSKLTAKECPRLSGTINTNCIAVNLMMHITTWGSGYFENMWGWTADHDLEMLDGTQIDIYTGRGILIESVNPTWLYGTGFEHAVMYQYMVHGANNLFMGLIQTETPYFQSLPPAPKPFDKAVGLFKGDPNFSKCNPAKPSSCMAWGLMIESSSNVLIYGAGIYSWFQKYAQDCLNTFDCQSEIVHLSNDKNIYIYNLATVGTVDMISSPGAKLMGSVHQSPRSNVSSINGWLGDADGSEADGNEPGATITLKSTIWLWPATQSDNKGTMTVACTPPCIFKFPPLTFPPLQPPPMTTTWDGKPYTVTPPVVKNATAAWNPVTYNNSGVVTTTPTLNVTTIPVPPWDCGAACGGHEATFPPISFPIPTPKDAPCWIYCDGAKPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8B9</accession>
    <name>A0AAE0K8B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_285963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8B9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="25237" checksum="9C0F6A85447A7E9F" modified="2024-05-29" version="1">MHRDRRVCQGVATWFPCFYPSFPPLFSSHRQVSLSSMIGRCRVVAEHPAPKRGIKRKLAQHAQQARQADEREPSQPRTRPASHESERACGFSSGVVDPLITKGKSARNIVLIGRAWSDYCPRQATFAFGFQTRNMGKQGKKECNDEIKKLLCPFPPPSSESHSAAGPPSRDSVVEEARGGGISGPEHREKRFAISQTRGLDRQLHLMTPSRRAAPLILYLRICPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9C4</accession>
    <name>A0AAE0K9C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_551101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9C4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042070407" evidence="2">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="37173" checksum="6F09FED259725345" modified="2024-05-29" version="1">MKATTFIQMSCLLGSALAAQESRQGRNSQQNQQTQKAQQAQNSQQNQQGHNTQQNQQDQQAQQNHQAQNGQQSQNSADFILPPIKFDIPFLSAIFPNPTATASYIKPAFTSILIPIPAYTLTQSAKTSGSLKMSPNWLLLIPSTQLNKEEYQSRAADQKMEFQNLAASIKSPVEHTNSVVRAQGHQNADDLSAMIAAPMKQLEGDFNKVAHFNIAGLRNGITTDSLGLGSVVDIVCSLLDSVIGLVEGLLGPNGLLGPSGVLGQILGQSGLSGILASLSGTSAESPTSWPISSTACSRPWAAWFQVGFPLYSRLRLVVFLLFLTLSVFKGLKNIIPGVTPTTTSLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9P5</accession>
    <name>A0AAE0K9P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_401547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9P5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="672" mass="75472" checksum="B0374BA48618A46B" modified="2024-05-29" version="1">MLPFYQASPLRCLPLRGSSPSQGSDKCVRNSEKKIDHFETRLAGIEQMLRDLTTSINRQTPSTSTPGTNESGPDPHLFRASYSSVSGDVPSGSGFCDDEVNDQADSEFEGHSSMAAQTVFASEFLEQAVAKTSLRELNPTMESALASLQQIVSMQNRTSAHESRFLHAKPLPRGGIRELPMPPMHLVIALLREIKEKPPITFTLICGFIAIENFTARCQKVYFATEDYSLATFGIVNALLYFLIQEKAEEPSMAELRKYHTLCRDNLETALANMPLLMAPRKENVETLLSGVTYAVEISKLTLAWQLNTAASIMCQTLGYHRQPVGQPIDETKASLFWFVYMFDKALSLRFGRASTIQDYDISIPRAFGVGVRVPDEAWKVVLNQWILHAECMGKVYEQLYSPMALTKPVEHRAEAARQIILRVDELARDREILVLHMRGKGLISGDMRNPYSMDMCFMSDEVMHYASLSLIYRALPAPPGVPGTFNTECITSARKAFKKHHECMQLISKNTGMTAGYIHWTLFYVPFVPIIVIFCHIIETCDMEDLRRLGEFVDSLQPICNISEAVDRFYRVGQVLNNVARLYVEAKAQQQQDQDMIHLNDGINTYLSQLGFFPDTPFINNTNDGDGDTGMDINQASQLGNWFSGNRHILGLVEEDPSEFEPRVWAAMVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE37</accession>
    <name>A0AAE0KE37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_261494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE37"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3374949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="604" mass="65917" checksum="91F3B12C8F2DE9F9" modified="2024-05-29" version="1">MAGRFVRASKYRHVFGKNTRKEFCYDNLHISRNAWDTNLVKANPEYLAVNWESSGGGAFAVIPLNERGKLPDQIPLFRGHTAAVLDTDWNPFNDRVIASASDDGKVFIWEVPQGFSLYTDAEEPASVAPVLKLSGHSRKVGHVLFNPAAENILASASGDLALKMWDITTGQANIVLKHPDIVQSLSWSANGAMLVTTSRDKKLRVWDVRQQSPVHEYEGHAGAKNSRAVWMGEHNRIATTGFSRMSERQLGLWEPGRKDPIGGLTSLDSISGVCMPFWDDGSNCLYLAGKGDGNIRYFEYENDKFEFLSEYKSPDPQRGLAFLPRRGVNLHENEIMRAFKTVNDSYIEPISFTVPRRAETFQSDIYPPAVGTKPAMSAKEWLDGKTAFPPKIDLESIYEGNAPIEVAASAQPSAPISTPAPAPVAAPVAKKAPEPAPVAPRSPPVAADQKASLSAAADKFQDAEESSDDDSSFEEVARPPPRAPAQVRSKPPSPIATTPAAQAKPPSPIKSPQPSAPLASRAPPPAASPSIAASVEQSLEQIKYLLEQQSKIIGVQSEKINAQSDIIMQLTTEVETLKKKVSPISQDQNERIRQLELELESARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KES5</accession>
    <name>A0AAE0KES5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-dehydroquinate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_562828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KES5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="4">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42425" checksum="41F7AA3F6A8A9734" modified="2024-05-29" version="1">MSDMKATVELTNKGFSVCGYEKIVYDFEFVDGVFDTKNRQLADCYTRWQRCLAVLKTHKTMVGEKAKSMETLLEIVDSMSAFGIYRKEPVLVIGGGLVTDVAGFACAAYRGNTNYIRIPTTGKCSTCCTSTARRSSRQHLGGLIVPAWRSERRRTGYAARGIYEMLKLETPNLHELMLDRIIAYGHTWSPLHELVPDTPLRHGHAISIDMAYSTTLALQRSVLSPQDHDRLLTLFSRAGLSMDHHQFDEPLLKSATAAILRTRDGKLRAAVPISPMGKCIFLNDVSHEEMCAALAEHKKRMKSFPRAGEGIDAYVDASDTGYTVGGGSPGVGAGDASAPRSMAGVRNSSECDIQGILNGSSSAPRGGALLEGPLKGQPAVVAETVIVPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEU8</accession>
    <name>A0AAE0KEU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_258632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="30459" checksum="08E62035882D234C" modified="2024-05-29" version="1">MGDQRSRGQPSRPVGRQCSFAPTQQEPASRRIRKIPIIQRKEEKDQKASASQHGNPSSRAAKKGTHFTILESVRHPPYPGRHSRLESYFVSCQLVFVFPTVRFPLCFRSAMRGAISHTSCSPQQSLSQHMLCFLCCMIYVQTPPCPAPYLTHHRHHHQDHLQVRRLLVSLFFRQKRERRILLHVLCTIPSHLTPTQLPKLGLYGGWYIEPLFSQPSLAKSDPGFRFLKHGYGQLFPYPFSHFPSSHHRTILLMPTLPKGPELACLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEW4</accession>
    <name>A0AAE0KEW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12 15">Catalase</fullName>
            <ecNumber evidence="4 12 15">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_399373</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="2 12">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 15">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 15">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4 12 15"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEW4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 12 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 12 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042230101" description="Catalase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="18">
        <location>
            <begin position="59"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3375231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="730" mass="79309" checksum="EFABEBA9C7A4AFB4" modified="2024-05-29" version="1">MYSATALLSWGSLLGAALAACPFADPSFLKEKRDEPAPAAPSGQFLTEFEVDDNKGFLTSDVGGPIEDQNSLRAGARGSTLLEDFIFRQKIQHFDHERVPERAVHARGAGAFGTFKSYGDWSNITAASFLSAPGKETPVFVRFSTVTGSRGSADTARDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAIQFPDLIHAVKPSPDNEIPQAATAHDSAWDFFSQQASTMHTLFWAMAGSGIPRSYRHMDGFGVHAFRFVRDDGSTKLIKWHWKTQQGKASLVWEEAQVLAGKNADAHRQDLFDAIESGNGPSWELAVQVVDEDKALAFGFDLLDPTKLIPEELAPLQKLGVMTLTANPTNYFAETEQIMFQPGHIVRGIDFTEDPLLQGRIFSYLDTQLNRHGGPNFEQLPINRPVNTPIHNNNRDGAGQNFIHKNKFPYTPNSLNNGFPAQANQTTGRGFFTAPGRATTGNLVRALSPTFDDHWTQPRLFYNSLTPVEQQFLINAMRFEASHLTSDQVKQKVLAQLNRVSNDVAKRVAVALGLPAPVPDPTFYHDNVTQGISIFNSTLPTVATLRVGVLASTKSADSLQQAAALKQRLAQDKVVVTVVGETIAEGVDMTYSSADATAFDGIVVAAGAEALFGAQAKASPLFPTGRPGQILLDGFRWGKPVGALGSASKALEDVGVPTANATGVFTGTEVDGFAKDLDGGLAVFKVRLFLSRDCFGCFRERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEW8</accession>
    <name>A0AAE0KEW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA splicing factor ini1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEW8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="108" mass="12202" checksum="9BA6B0154B01B77C" modified="2024-05-29" version="1">MSRHHPDLVMCRKQAGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKTNRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFW2</accession>
    <name>A0AAE0KFW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_419552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="892"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="106"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="431"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1102"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3375110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1346" mass="147369" checksum="C9F61ACDC0FC3EEF" modified="2024-05-29" version="1">MAGSVSEKTREAAVAAPSAAASSHGDSATEDGPLATQKQQKSPVDLEKADTRVVVPKQALSEDEAFKHLPEREAKLLKDQVFTPNAKVGIATLYRYASRNDLIIMAVSAVAAIASGAALPLMTVVFGNLQGTFQDYFSFKMTYDEFTDELARLVLYFVYLAIGEFITTYVATVGWIYTGEHVSAKIREHYLESCMKQNMGFFDKLGAGEVTTRITADTNMIQDGISEKVSLTLAAVATFVAAFVISFVSYWKLTLILLSTVVALLLSMGSASRFIVKYSKQNISAYAEGGSVAEEVISSVRNAVAFGTQDRLAKQYDTHLVRAELFGFKVKSAVAIMVASMMMILYLNYGLAFWMGSRFLVDGAVPLSKILTVMMSVMIGAFNLGNVAPNIQAFTTALGAAAKIYSTIDRMSPIDPSSEEGIKLEQVRGTIRLEHIKHIYPSRPEVVVMDDVSLEIPAGKTTALVGASGSGKSTIVGLVERFYSPIEGSIFLDDVDISALNLRWLRQQISLVSQEPTLFGTTIFENIRHGLIGTKWEHESPEKQQELIEDAAKKANAHDFVVSLPEGYQTNVGERGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDVASEGRTTITIAHRLSTIRDAHNIVVMSQGRIVEQGTHDDLLEKRGAYYNLVTAQAIAAVNALTAEEEEALDQETEKILIRKASTQNKQSDSKGGYIEDPEDDIAAKLNRTTTQKSASSMALANRKTEKPIKYSLWTLIRLIASFNKAEWKLMIGGMFFSAIGGLGNPTQAVFFAKLIGALSVPITPETIPQIQSDASFWCLMYLMLAFVQFISFATQGILFAKCSERLIHRVRDRSFRTMLRQDVEFFDLDENSAGALTSFLSTETTHVAGLSGVTLGTLIMVFTTLISACTVSLVFGWKLALVCISTMPVVIGCGFFRFWMLAHYQRRSKRAYSGSASYASEAITGIRTVASLTREVDVLQQYRESLAIQQRSSLISVSKSSLLYAAAQSLMFLAFALGFWYGGTLIAKYEYDMFQFFIVFSTVIFGAQSAGSVFSFAPDMGKAAESSRELKTLFDRKPLIDTWSTDGSKVKAIDGSIEFRDVHFRYPTRPEQPVLRGLNLSIQPGQYVALVGASGCGKSTTIALLERFYDPLAGGIYVDGKEISSLNINDYRRYIALVSQEPTLYQGTIRENILLGAPHEVSDDQIEFACKEANIYDFILSMPDGFNTVVGSKGALLSGGQKQRIAIARALVRDPKILLLDEATSALDSESEHVVQAALDKAAKGRTTIAVAHRLSTIQKADVIYVFDQGRIVESGTHPELMRKNGRYAELVNLQSLEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJU3</accession>
    <name>A0AAE0KJU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_237070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJU3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="806"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128995" checksum="DDAFF51234226811" modified="2024-05-29" version="1">MSYSNGSGGTLTLPSPTHVHRVDVSSAVRSLRRSLSRSPSKFRLSPGPASPNTDPTANYRHSPTPSSSARFEITPILATVSTTPVGPNSQTSFFTPQPSVVTPFRSNAKLSMRPARTKPATSRPLSRTRLSPKSPLKRVFGLAQDSGNPIPSSVSGPEARGQENPTFSDFALALSPSSRRNLEKPSRHSMHLDVSGSSKHGLTTRFIEANNEPFPSTSVSPLKRSDATMSLDQSNPGSPVAKRRSLHGISSLGSEFDIFNYHPPVMQKGFDIHDEANHEYQLTSTTASISAPQFREPLPSPTPSAVPKRTSSLRKSTLQQRHGDSRTSWGRRAGEKQLAQLSANETTTPGTRSRPRLSLDQYLPPDERGSPFSPQAPLPNPSIHPVGPRQANQPHPLSRTLTQSSSGSSLPDESPTHIPVHLGEKPRVPMNFSKSLPPGAPRPMNDSDPVATPEYKRAKPFQAAFHSTGLISKMNRNPELGMPQRPGAKVAMPDTPCKKQPYNSATYPPQFGSGRRGSRVSFGSPSTPFGSTPFNPPSGPIRGNPFAVQDKPNGLIFHGVRPNHARKSSLLSLDGDDQTAAVDDFPPTPTKNLFFKSFSTPAQGAQPRSTTPTLPVVTSMFGLGDDRPGSNSSCKSQTSQDAWRTGGQKGNDRPFDAVFRPSTPNPRGSPRLSLSLSSLSGHRAKQRLFATPVPPVRTTPTIYAVESTRLFGTIKTDTPTTASPLNPAEFAVTSSPQTPQDLMAPPDASRLSISNSQDEGGKSRPPATPTTHTRQVFLGFGDRRLSITPQNGHGPKDIDEALVTRFDTSEIIGEGEFSQVYRVVKSSVPTSLSSVFAATPSKRTPSTPVCEIVYAVKKIRLPAYGAKERESKLREVNILKSLTHSNKIVHYFDSWEQNSHLYIQTEYCTEGSLDGFLRTAGRDGRLDDFRIWKILFEISQGLAAVHDAGFIHLDIKPANIFVNFDGYLKIGDFGMAAQWPAARGIDGEGDREYIAPEILLGQFDKPADIFALGLIVLEIACNVFLPDNGPLWQGLRNGDLSAVPSLTCGEAGAIVRDANGVPIELDSAGTPNVHESASKVGFATSGKRRGFPFEAMTHDPSNLFGGHKRSELLDPPTFMTDPKDANSLDNIVAQMIKPNPADRPTAQQLLMLDPVIWVLNRRRAGASVYEGNWGPQNGPSVAEIVDTEMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKH8</accession>
    <name>A0AAE0KKH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial LSU ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_525661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKH8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17362" checksum="9D5F8371E4E4E99A" modified="2024-05-29" version="1">MSRLAISSSPLLQAALQPSRSQLLQRCLAKPKMKTTQITRSFSHLPSLRPTTLSSSSSSSSSSIFRQTQTPLARLPATATNSMSAEGEVLDLVPKSSISAHPAFGGIASQIRCGPRPTMSGHSRLVQKRRHGFLSRIKTKNGRKTLQRRKEKGRKRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL02</accession>
    <name>A0AAE0KL02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_478664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL02"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3378031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="360" mass="40080" checksum="F786D7185F055A11" modified="2024-05-29" version="1">MCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAIARLDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGSESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1Z7</accession>
    <name>A0AAE0N1Z7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_455970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1Z7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="38067" checksum="0E755A81A3B541D6" modified="2024-05-29" version="1">MALPPLASRNPTKDDVGDYRLIKQVADVEVGIPTVCMQNSKFLSRDGQTIDNVLLKANLKLDGTSYRLGFGSSFLLEDTLVLGLDVTHPPPVSADTEKSVAGMVANVDRDLPQWPATLTVQPVSRNEIVGPDAYEELFDPHFDRWFKHVGDKVPRNILLYRDDVSEGQYDHIIFREYRYLRAACVKKYRSATRKLSYQASLSSLLTRAAIQGTVRPAHYVVVVDQIFRQPDLAASKIHNAAEVPEDLTLALCYALGRCTMAIGICAPARLADLACNRTQPYTPSGPKLYEGVKKGSRFPDPDSPKKKKEKKNNKTLEKKQLIQEESKPEEVSELQGDCLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2M3</accession>
    <name>A0AAE0N2M3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_423982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2M3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000014">
        <property type="entry name" value="Oxidoreductase, FAD dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF281">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="551"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3367873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="650" mass="71665" checksum="D9B1DF5105FC61D2" modified="2024-05-29" version="1">MALYTVFSRNIRSFFGRQTSALTPLRVVGAARSGDVIRIQSAASSPLFNGRLQTAKRGISQLSQKPMEKLSQDNRSRFPLSLSQSRQASTATSSSTANMGSTDPQHTYHTSGTQDPVWVHKLPFSSIPQFPALDRDIEADVCIIGAGIAGISTAYELIRRGGKKVALLEARDVLSGETGRTSGHLTNDLDDGYLEIAKKHGDAGAKHAAESHAWARDRIGEIAKELGIDCEYRRLPAYDVSQYSVGDPKHEEELKELQDEAEYQKKLGIETRFDENLKVEGWTGPIDQRGGLIADNQATFHPTKYLAGVLDWLKQQPDFSCYTRTRVMSVDEKGIELLGLGHKSVAVTTESGHTVKAENAVEATCVPLQKLSVITQLEFYRSYCIAVKVPRGSVEDCLLYDNAEEYKYVRLTACDEKNDYLVVGGCDHKVGQEETTPRFAELEKWTRERFPQAGKVDYQWSGQIFEPVDFMAFIGKNQGCQKIYIVTGDSGDGLTHGVLAGKLIADEIDDIPNEWASLYSPKRLGSIIKSLPSMVAHDLQINTQYKRFLQSDITDIEDLVPGSGGVLNKGVSKPLAIYKDENGKVHKYSALCPHMKGVVCWNHAEKSFDCPVHGSRFSKEGVCVIGPAKANLNPEDEQGKTQQEEVVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N393</accession>
    <name>A0AAE0N393_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_488830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N393"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="254" mass="28031" checksum="88E560AF19A6A902" modified="2024-05-29" version="1">MSSSVNHDGPIEITARGTDLQLDKEEPVTESNDSADEEGVDQPAADSAALRELFRAVVDAICDGTREAFPSSPAPVTPSPPAEVDPQFQEYWHGVFTRVLESAASPDSAMPRYLTAPAPAKKFSIKLFDNKHPGQCPCCLPDGEPSITIEDEGGARSEDLIRTLRDYMYCPDAAPWVHVMDERDDVTVPLSNALVYSVDWMSNWSDENPEIYMYCCPWDQYKVMTKPRSEVVVVNGENEEQEGETLQNGDAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3D1</accession>
    <name>A0AAE0N3D1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_529015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3D1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF1">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="215"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="926" mass="102634" checksum="876EA21009783B48" modified="2024-05-29" version="1">MASPTNRDASDWPANAMSNLQLAPRTTRPRSMSDGSQTWKSKGFSDLMEGFVPETPTVKRWDGIERTCTIWNNLERDPELWYRTGNCFVHLYGKGQSHRGPAFKVSYDGLLTAKCHPLIARFITHDALNPAAAYIEQGQLDLLGKNDSNGKIDLYIPPPLMATKLEIKRFHLGVRNFFAWVFGKPVVGDYLGTALIRLLLTMAEFRCPSADNIDALMGYLNGQGYLEMGNQPIHALAMLHVAENFQFRELYVDSFAHCVGMSDKLFTAPEYQAGIITSVTRKLIRQVRAEMDVKLAHAGVMLRNFLEDDLSEAHIGLTESGRAHLEHFRTFLFAFFSSRLGYYPPVSIDNRSLIFERNTYHLMREDVEALYEYLVDRSFTVSKNMPVLAQGGICTLQSVHGFDLRNKYTPLPHPLPLLPEIAPSSHSRRMSISWLNKPDKLKPDQRLIAHAALVQATNSQEPDLLMNPLVLAYRKFEEESLFSPFKTDRHEKLSQVDARKIRWILVYSIYQVLRSCTDDPPECQDTDGIRYNITINMSYLPPWREGRRQVSIRSRDSPHRNHSFSSPNPILPVPITPALTPESEHASSASAIQPDVDYFSLTRQKNTPAPGRRSRLGSPPVIPPRVRRLNTTLRRSLCLSIPSPSSGMTPNTTSSNTPSSSSTAIGSAPDTGQRMPPYQEIIVQGYGNGTNSVRSGIVELLSVATPTATDTNSTTVGNRLQEPCEDLKPQPLAVRSKSTASTSSTNSIASSTISRFSNLSTVSTVSTAPTATSPVEWIIPPPWETKDADPSANTGDNITIPEIIPVIPLRRRSAPKHNIMGGLKLDEASPPPALPRKNSRRKLNELMQPNPLNIYKGPELTSYDAGGCQPVDVSSIDHTSSDGEGPIDDTVSEVDSFTVPGRGEGKIGDVLDQFSDVGGMRDMSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3P7</accession>
    <name>A0AAE0N3P7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_534405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="43"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3368264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="473" mass="52518" checksum="127852F80736E763" modified="2024-05-29" version="1">MALQYLQRSESWILAIKFFEDASKVTFGRPNTGFKTTAKAAMAIGSIDSIYPQTNLQKALSTYFFEDTPLFAASASGHSQNTTRVAVTTAKDGPDGGDTATLIANYNRPSGDWSLFEREDNPASDMKIWEAGLATSAAPIFLPQFAKRTTNYRDGALYANCPAKVALDERERLWPDQGASLDVLLSLGTGLQTRQWKLPKALRFSFFNPILKSFQDQMNSTSMWDSIESTSPFRARLHRLNPPVTAANGDYVDLDSYEEIPFLRQTVATWAATPEIATKLQRIADILITNLFYFEPASGEPADQHHHHHHHHHHHHHPHPPPLGSPLLGGDFSLQGSIRCRLQHESRPLTTLLREKVEAFRYTTATRNEAVAVGTIPTRRWHLLCNTAGQTKPNKMIVDEGEGSIKKFRLEFHHLSGNGGGGGGSNAAPTQHDVSHPHYVIALQLRGNNEMFPISGFPATLEELKARSQSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6Y5</accession>
    <name>A0AAE0N6Y5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase/enolpyruvate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_402125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6Y5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="210"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3372525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="406" mass="42441" checksum="A8EE5667D17F7D4D" modified="2024-05-29" version="1">MSDPKPEFLRFTGHRAFAQRLVLSTLTGRPVHISKIRSSSPTHPGLAPHEVSFLRLIEAVTNGSAIDVSYSGTTVAYQPGLITGTVAGAGASVGDVIEHILPANCNRGITYFLLPLAILAPFSKSHVNVRFSGPGVITAATHGTGDISVDTFRTAVLPLYALFGIPPTRIELRVLARSCAGPGGRGGGGIVELRFASQVRLPKTLHLNRKPGRIRRIRGVAYCTGVSASHNARMIQAARAVLNALVSDVHIAAQYDPSPLVADKNAPAKKRKIGIGFGLSLVAESSAMGVLYAADEVAPPEGGVVPEDIGTRCAYQLLEIIAQGGCVTGASSSTLLTLMAMGSEDVGRLRLGRDVVGREETIGLARDLKTFGASSWGVRDVDDDDSGDVIVSVKGTGVGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N745</accession>
    <name>A0AAE0N745_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_282930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N745"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="225" mass="25527" checksum="FD09FE4A5067DB4F" modified="2024-05-29" version="1">MAAAGGKQPPVTPSPSQSAAFGIELAITQIEGSTRNPGQRWLKEQCLRRDENRCVLSGLIDSGVFKDMSPGERRGNKRTDTECAHILPFALSKLEEKNATQTKNKTTTWWALHQYFPALKNKIRADTVHQPGNAITLRSVLHGEFNRFSFGFRPTNEEHKYYIEILDGDFYEAAQLPTTVTFAQHDTRVPRTDPDILDVHLRISHVLKKVGHRYKCLVKELEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7U0</accession>
    <name>A0AAE0N7U0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_551405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7U0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="170" mass="19068" checksum="A6ED6A93471BF4AE" modified="2024-05-29" version="1" fragment="single">LSSYAASSLCLAGSLRTFHARRYDAVEGPRNMRASAVRTEGPKKQFRRPHNTQVSTMATETMLRRSLRLRRPNEAQSRTTTHGDIKPVNPVYASKHRSDLDSVCDHPNTPVTSITTISTSARHKHQDGNLDCPRHQCLDDIDPVPGKHQVAGLNYPRSKHTIDDLDCPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NA34</accession>
    <name>A0AAE0NA34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_481580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NA34"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="326"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="467" mass="52000" checksum="1D21691B15BEDD41" modified="2024-05-29" version="1">MSPPPDTILVKRKRGTEDGPVDFLRVEGNKRHRLVSGDANWVYQRKQIDVDRADHAVQPTVPSIQPTQEGDENRPVLPLRQAKATSTAASKAPATTTTHELALPSFPTRRFHLSRSISPLLTPGGVKKRTAAAVFVEREVKEAKKQRDAKVAAASVLISQTTLSQSSQSALSHESFIRDDATDEHLAVPPADAQHQQLPYHVKQKRPSARSRPNTSNATKPTLPPSLVNREGVDMDQLARDMDAYTVSQINTNLDRMDKSSAAAAPTGLASGSSPARKSKFKPKAPALRYAERHPEHLSEVEREKAAKKAAEAMDIDEGDSVVDDEDYVMETYERVPASRMRDQAVPAHRIGLLVFDTEPDRIDFFYGEEGDSEDEFPEDDEDENAENYYTADYPDEDLDWDDEFDRNPYHFVNHSASDTEEYDVTAFVDADEDDTWGPEADEPKDLTSEPLELVAIITQIIAETIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBE5</accession>
    <name>A0AAE0NBE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_417041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBE5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="274"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="887" mass="99092" checksum="19510C813AC60C72" modified="2024-05-29" version="1">MALLNTNEILQLNNNVHTFVLVRPNQVDIEDVDLFVVQPPAAPLDPAHRLPTKSMTHLCDTCRSALEYFSFCLNSGPQKDDDTKLPASCLLHEGATTLQEGEDERCHLCILLMANLRIKRLAMQSIDQSNIEMCWQQAGRGENPKPARLHFALTHRGHDRSTNNYWNILKLHLWTDDEFDESLLWPGDWKPSEGRPALERHPSTESVQTRDNALAWLARCEADEDGKHDQCNRQVSGEWMPTRLLDVTTAIQTETLKLIAPDENPEELVSDRRYVTLSHCWGAWGGGGELPVLTTDNLAERLTTGIPLLELPQTFQDAVQIAHWFKVRWLWIDSLCILQDSADDWSREAIMMYDVYKNALLNISADDSPDARFGCFRNRDPLAVLPMQSDDNNDSGNPVTTTTTTNCWIVPDTNAAFEGVIDSPLAKRGWVFQERQLSRRVLHFTSTELIWECCASSPYFASEMFPGASATVTTKPVYKTVFGGKPKFQTQTTNLSSTSTPDKLYATWSTLCREYSAKKFTYPHDKLVALSGLAQEFQASLFPDDTYMAGLWRSTLPSSLLWQSSNTSSRIDHTEEWEGKYIAPSWSWLSINGAISPGPFSSSSQRTFSLVNILNVDIVPSIPSKPTASLQSASIKLACYLRRVEVRPDYEKKPWYLMAIGGGKSHKLIIMDDEYGQEETGGVIDNFHSDAFDHSFDVASDGDSGPEVVAGFFLPLCVSLPDETSGLCLSGLLVEPVGGEDGDGNGETFRRVGVLRVYGLHCRWIKYKAAVQLGGAATEEGDWESLAKVLTPSHESWDKLKKDDEDDVEEAGSESVVDDEIVGVLSDKKPKELEAADNKKGNQKAVELDLTPLDALERLYALDKTLLDGSELEARFEKMVPQRITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBL6</accession>
    <name>A0AAE0NBL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_234288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="306" mass="34161" checksum="5F6CA846E8333CB2" modified="2024-05-29" version="1">MLRISYWVFPIVAGMVWLGTLLGLLLFWIIDDNRTHYPSMADSQLIAYISDVGASRLKPLFVTGCVVTSVFLDISFLADLWLRHRGRLVPNTTRGEKILSALTIVFAILGTVGLILLSVFDTAHHPRLHDVFLLLFIAGFVLSAIFICWEYQRLGIRYREHRVLRISFWIKLAFVVVEILLAIAFVSCTFTAHYNAGAVLEWVIAFIFSFYVFSFYVDLYPAVRTKNGTTGGYRTTGAIKSRYSAAQRGGGVGARDMAMAMEEGDTSDRHLTSHSPNHTTAAAAPYHHQPRTTTGYPATNGVPSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBS1</accession>
    <name>A0AAE0NBS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_221341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBS1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3377625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="131" mass="14551" checksum="20BD2DB1735385F4" modified="2024-05-29" version="1">MFCGNFNTGSKRDVEKCLKGMSDVPNWQCVTPAKTCRRHMCVNTTGITVCNDNDHDITLRCDTIVREMALNPAILCCTYGQGWKGISGQQFTNEGWNVIISYANCNHPTDERPSMGPPDEPWGPNGECKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBW3</accession>
    <name>A0AAE0NBW3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_221667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBW3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="153" mass="17826" checksum="F776AD4CE39C0C84" modified="2024-05-29" version="1">MDTYEVPLLEPAEKPQNDDGVSWTAVSSCLGILSLHVQLRDVSSSSTEGEHTKYTVDKFQRRLGPPLTSFTDLARLLPTVRSGWRLTQATKRRLKEQAIHEEANQLFKRVCKAYENNIIDKSDYDDWKGWIMAATEQKNLFFIFWIRSYLQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NC32</accession>
    <name>A0AAE0NC32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_478147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NC32"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="594" mass="62805" checksum="CF1B9685C48678B4" modified="2024-05-29" version="1">MAVDAESRRRGDDDGNLSDSVTVGEDTPLLRSETASSLTARDGSPAILPGRRQPVPVNLDSNGLEQPLGRGQAVSIVLSLWALIFLQAANMSGISTTQSDIAADLNAYEYAMWFTSSYMITMSSVAPLMGRLAMIFSPGVMVLISSFFLSVGAFVTSQARTFVVFIIGRVLVGVGAGGIMTLSLILVIQLTSKRRRGLWIGITNAGFTIGVSTGAVVFGALLPVIGWRALFWVQSPIGILAGFGVFFSLPKLAMHSASKNKTTREKLAGLDYAGAASLTLTIVLFLFGLSGKIQLLPIILSLFTLPIFLAVEHYVARDPIIPLSVLKDRGILFSCFSQLGFMASRWTVLFYAPVFVLAVRGLSPAVAGSVLIPTNLGFGLGGLVVGWLHIRRAGSFWLPSALSLILFGASLFALSFVSNAASPGGLYVLVVFVNGLCTGAALNYSLAHLLHLSHPDLHFITTGLLATFRGFAGSFGTAIGGGVFMRNLRDALTAGFIRLDGGSVLSEAREKLITVLIGSPAAVSDADFLTPPEREVAVAGYERALKVLYTAAALVCVLACVLQAGTGWAPPPVTDEEEEEIEEAIAEHDGVMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFZ6</accession>
    <name>A0AAE0NFZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_544849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFZ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3380779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="395" mass="45015" checksum="8D1EA6382BBC51EB" modified="2024-05-29" version="1">MSQPNETSAREDVVIAVMGATGSGKSTFIKLVTQRQDIKIGDTLSSETDCVCSYNFTHEGVKYVLVDTPGYDDSSRPDSEITNSILTWCRDSLVSGQKLNGIIYTHRISDTRMGGSALRNLRMFRKLVGTSAFQNVVLATTFLEAISGAVRDAREKELQDNPDYWGAMRAKGARMVQLERANRATGLAVLQDIATNGKIILHAQDQIVNQGKAIAETDAAKEQTAQLDELAKKLEALRIAKEDELAEAERQQSLRAAEARQQAELEMKRKLEEERRLTEAARIRVQQEAQAEFERQRWQLLMQQQREEQYREQLRELERQQAVEIQRQQAVETERKRQAEVARREKYQREYCCRGYRPKWPCDDCGKDVTRMTHYYRISSAEDAATIAGRTSILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGS1</accession>
    <name>A0AAE0NGS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_198832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGS1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041947482" evidence="1">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="157" mass="16935" checksum="DB4465F54ECAE68D" modified="2024-05-29" version="1">MRSAFDLGLRFSLRAASLVGLSQVSAQPQESEQLQLAIAIDCRFVVGRSAGNWAQGEMDAVLPIMRLQSGINPAQWGILDEHRAERDQRCGSAWRIEFVIALPCPARAYPQSESLGCAKWSSCTAHSGKRRGKGPQKSLVRPSCLGIAASHCCTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGY9</accession>
    <name>A0AAE0NGY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H63DRAFT_396355</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="156"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3381378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="365" mass="38601" checksum="6499DDE23F0C7681" modified="2024-05-29" version="1">MAAARQVNIAIIGAGGVGKCFLAQLEQLAQRRPNPKLVLCYISTSRKAVYSNEYSPIGLDIAVSALASSSQTPLALPSLAEYLSESDAKTVLIDNTSSQDVANAYPLFLSLGVSIVTPNKKAFSGSYKLWKDIFSASAQPGGGRVFHESSVGAGLPVISTLKDLVETGDEVTKIEGVFSGTMSFLFNSFAPTSGSGGKWSAEVKKAKELGYTEPDPRDDLNGLDVARKLTILARLAGLEVESPTSFPVQSLIPKELESVASGDEFLERLPEFDAQMEETKAAAEKEGKVVRFVGGIDVAAKQVKVGLEKFDRSHPIASLKGSDNIISFYTKRYGSNPLIIQGAGAGGDVTAMGVTSDLLKVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHD4</accession>
    <name>A0AAE0NHD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_475921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHD4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="434" mass="47995" checksum="8713BD54C7234CAD" modified="2024-05-29" version="1">MASVFGFVHRAWQIIRPPLQPAKAPDALKFGILGAANVAPYALFLQAKQHPDVVIHAVAARDKNKADAYAKKHGIPVVFGSYQELLDDPSIDAVYIPLPNGLHFEWALKALAGGKHVLLEKPSVSNATEAEALFRSPLLLQGDAPPVILEAFHYKFHPAWLLFMSLLDQPNVARAEAHLAIGGFSDTKDIRFNYELAGGALMDLTYTPSVVRAIFGAEPTQCTRCDVQTLVNVGGSEEIDAKFDAEYTFPNGGTGVARGNLRAPMREMLRPLPFATAVHKPEVISNHPPSGGGVSLPDGQEELRTRTVTLHNFIASSLWHRIDIIDEHVIRKTDGTNEPLKKWTVRESKKAYTLRDAGNNIVDSERWESKEYWLSYKYQLDAFVDRVRGRVPVAWVDGEDSIAQMRAVDMAYLKAGLKVRPTSRYYSPPVAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHD8</accession>
    <name>A0AAE0NHD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_546087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="33914" checksum="5D2730A5DD2390B7" modified="2024-05-29" version="1">MANTFTVLRSDLKIQTVPRKKALTTPQRPQTYRETTKPPMQTDNEDKYSPQTQLRIRLALRLPGRYSATSLRLRPCGRNNRNGRPCSRARPRPAPVGKWLLWRYRTKKYNLPRGSCGGRTRRRSVAQIEALEYMRQGIGRLTTALDELRDFERTCKIYDTPNTSRLHWKLDQIDWKIRQERRRAGKDRRVGTLLNPNRIMIGADVFSLRVRDAVLKGQCTKSNWPAQSEINAYKRRKYRGEFICTKKKKKKKKKKKKKKKKKKKKKKKKKKKKKTKYSQKTNEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI82</accession>
    <name>A0AAE0NI82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SIP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_217222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI82"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="96234" checksum="6BEDFFB93D3D9057" modified="2024-05-29" version="1">MGNASTKESRGGDQPHRGHHATLVPGFESGATAAVPSDRSSNRRNRVSRGDLGGLLGLGSPAGSSAHPDPPYERRETKQEREARRLERERVARLEERARSMREESVDGGYLVTMGTYTGPEEFNKQIVRQLQIERKIAPFWRGLNDVDDQWTEPQIIAAARGLPVPPAGQTPPDELIPRPPSPDSPMASTQNLNNLTVPMGGRTQSMTSEHSQSNAGSALPSPVSNPPQRTSSPFKPRGKALAAVLGGASRNGSTTEIVPREINLPNDPFVNGQPLEVFLYKEATECPICFLSYPPYLNHTRCCDQQICSECFVQIKRPDPHFPEGHNENDPNHNPEEAAGLLISEPACCPYCTQPDFGVTYEPPPFRRGLAYTVSPIAVGTLNTAMSSSSSLNSATLSPGLASPGSGANRRRTQSLSAHASNVILTDKIRPEWATKLQAARAHQARRAAAATALHTAAFLMGNAETRVFRTRFGRRNTGGSGSASAAASPGGAGNAEGAPGENGPGTPSQVTLEPGPRGSSGRAEPRRSRMEDLEDMMFMEAIRLSLAAEEERKRKVDKEEKKEAKKREKEERKATKLAAKHGGPYEGHDGRSGHSSASGSTLSLPGLGFGRKRGNSGASNLRVEASVASAMANASTSASSVLDPNSKDKGKAIDRGSPAEGAQTNVAESATGSSTTTTSPRPIPSPHQSAGPSHLRQMSNASSISSSLLDSQPGSYASPSHLHDPRASGISLGSRSGASEDGGDQDRDRDPSTSTEPMFNFRSLAAVVGVSLEGENAGRRLSRIEDDDKEIEAEMLDEPKDVQPRQVSSNNSATPILLTKPEEATDSAEAERVEVVSATTHESQKENVKLGSGTASADKGRLPPPKVTVTPTTPLPVDDDIGEDSKQLGYETTVEHPREVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NIB5</accession>
    <name>A0AAE0NIB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_451295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3382017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NIB5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3382017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="438" mass="47478" checksum="C0719FEBF1FE4457" modified="2024-05-29" version="1">MYTSSTRRTQQTDESSARKMTSEIPLPLTDEEQMAVDHPITAEAGRSPVTALPLRLCLASFLSARRPLWDAALSKMAPMALALLMPTALTAITASMVVANSVALAHTELTRDHLHVANIVDHVVMLADRIVGTENRIADAEENQGRRPAPAGPNASSPLGDGYAQLARPPRIRNPNYRGLRASLYEPVLEELEAVQERLEPYHSEPGSSTVVQSPVYQADRPANAMPWSNSIEPSIQAAIANAAMRRDAPPAHVPAAPVHEESVYGSSPPSQPSRELSYATGRFSPPVGRESARGSVPPSFPATQNSAHGSASSAASSQETLHGRRRKRSESSSPERRPCLLSPPSICDRGHRRRCLYRSRQIVDDETEEDTPESQTEGDPSPFQWRESGQGIASLPISSPLAWSGYWGLAGRPLTFEDGGENGSGSALAWFIIYFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNM2</accession>
    <name>A0AAE0NNM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_172386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNM2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="19578" checksum="0308D2A98BF71FD6" modified="2024-05-29" version="1">MGLVKSEERCNDLWYGGPWPCPWYYSRCTFHGRGTGRASNKVRGEGKARHPDNGAARRGEDKDIVKYVRRIQFVPVLGIYCPLTLLVLGDEVTRQAGWRYRYGLALPLLQLGGDNETGRRFDLWFCFYPDFRKSGRKFIYLPVETTTSGPIDYGSLYVICRVRPRRECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP64</accession>
    <name>A0AAE0NP64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_472444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP64"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31530" checksum="B62BB60353948CFC" modified="2024-05-29" version="1">MSKLSAAVKGLINAPFARGGQMPAPARIREVYERIANEAREKQYGRRTWLTASAAATFTLNSPESLLVLHKVATTAAPSVAHTPLAAAELIREVGLKCISFNGIPRTINCLNAFRADTLDEPWAAQLETRSSRSVADEKTLAAVRKRGSALWESVYTPLDEKLYEKLALAHPDLPVYILGSHYGPLLADPERNADSKLAATGRCLTSIIAISCLRAQTGVGPQVLSHVYGLRKGISQGAHEQEAEASERDALVRVSEDEGLLWLLKSVDTISKAIGSNFVAHDGGPERLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPE6</accession>
    <name>A0AAE0NPE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_543508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPE6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="104" mass="11408" checksum="01CF025697379F36" modified="2024-05-29" version="1">MASLTSPPYRNSVLLIPKARRISFGSSNHSSTRTICAWFSEPDAARIKARIQTDPAQNLIHLQSLLGHLSPSGRTLGLDDSGNPNTSCFNNENFEQYINTSVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPN5</accession>
    <name>A0AAE0NPN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_181938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPN5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042168688" description="WSC domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="308" mass="31785" checksum="9D0BE93E2C27DAE4" modified="2024-05-29" version="1">MKSITLLATAVVAATSTVADLSMGLLGPRIISRAAVGTAPTEPQPAPEPAQLNVITYAGCFSSPGELKFNTTIKFNSLGKCAQETCLAGDFTVAASTGGNICYCGTKLPPKSTQVKETFCNLKCPGIDKEACGGATTDGQYYYTLYNTGKTIMLVNSADDTTNSGSTGTTTGPGTTGTGKPTASTTSQGNSAVTVTATNSATPSGGSNTVAIAVGVVVSVVVLAAAAIGIFLFLRRRRNKEIEEEHRRNAAVSAFSPSTGGTSISDARLDPVMAQRRMSDGSIADNHDYSRKILRVCFVSPSSPHCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPX9</accession>
    <name>A0AAE0NPX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_473043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="266"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="784" mass="88116" checksum="D38DA66EF046FBB2" modified="2024-05-29" version="1">MGRITSARKAAEKHGRRPNLSKVQTPSRRKDTAASGIQNPRTSTTRPRRQENSEILCLDCDQMDLEKAFTDADAFFSANWDLVLGLRAWSEPRFKFDGLLVTSLGGRLARLSSSCPLCRFMSTFSLDGSSEGPFELRAFPSFWALPFIKLKASVFRNRYRQLQEAILMVVPVGTKAPAASDAFSQAKCIFRAPTSAANATRGKEINEFIDLDQVLAWINFCTTHHGRGCPKPRKRRNIEVSQSIQGFCLINCDTENVIRSSIEEDFVALSYVWGDTTHEAVSSESAWPRVIQDAVTVTKMLGMRYLWVDRYCIDQSNNDEKHQQIAHMNLIYQSAQITIIAAAGKDANHGLPGVSMPRKKTPRVTVGKAKLVGLPDDAHNSVRASAWWSRGWTYQEGVLSKRRLVFTHDQAYYECEGMVCYECFHYPAGELHTQLKLNQESFVKAGLFNGVESNNANSFRLAASKDPGRQQERLFFHIKNYCHRMLSFNSDSLDAFRGILTAHKQKSFYGLSVSNIFPHPKANTETTKHLLSMKKCSQELSPELVSWWHCAGPKPPQRVPAFPSWSWAGWRGHVETHKQNFTPPLPISRHSIHPLDQKSPEFEGPYILLEMRGSGHYLRVDTALSKLESIEGDFSPILEPVLWVHGARLLDLQAADDLTCNATRVPANHCNPPSHWNGQITVSIIGGPHSLEIDLHMHMSVDITPSNLVKHLKQKTYIPLLMSRTADCLLFVVLALHPAPKDTQYWERVGLCHSRTTPIRQAILHGVAILSSVAKEGLEVMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ67</accession>
    <name>A0AAE0NQ67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_473276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ67"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="122" mass="13684" checksum="F8C1A8ED040E8F91" modified="2024-05-29" version="1">MASQENDEDFLKGMPPIPEDEFCVYGTVYAFPEHADALEAVYAETTRLAQSEPGSIYYSISRDSDDLAIFYFFEQYTGKKAFDEHNAQPIIQKLLNEDKYIRGVKATFAKPIKAAAALKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSN5</accession>
    <name>A0AAE0NSN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_144390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSN5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="39658" checksum="7C30463146737A6D" modified="2024-05-29" version="1">MTSRGEILDSEDEGSDFSPPKLKVEDDFVQLIDADADMTASHLQPTSQAVRSTDSVEFDSTNPSDLENMHQAYEEHAAAAQGEKDAASQPARSLKSTAKSASSTDVSVVERVRNEQLSAALAKKRAKPEKKPEENADVWDVPSSPLRRPTSSSKRATKTYGKRRRTGQQSSPPQHGNTNDIPPTQNPHSTVYDLTESSPVAPVKRQKTRATRSSASMEKDSDTPVAIPIFQAPSDSNQRSSRSGHGKKESSSYNFDSSLPEMPSASIYIAPSALTASQKREYKTISLSSFQSELGHGSPASPLPNLNFDVGEGMQHRSSGATVSTIANTPGRYAPSRLTAVLSDDLTHDEPGSSTGPPGRYLLQISYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NST0</accession>
    <name>A0AAE0NST0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_141634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NST0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF161">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="59350" checksum="877CEADFA51908E7" modified="2024-05-29" version="1">MASFSTVYEAIKAPLVLTGNPWTTPVVALVILTCAYSVSRIVYNLFFHPLAKFPGPKFAAFSNAPFSYWFNSGRQPYKILDLHRKYGPVVRVAPNELSFNSAQSWQDIYNYREDNKVFMKGSFYEGGSFATRGYTSIVTEPNPKKHHEMRRLLSHSFSQQSLSEQESLIAKTIDKLVLDVVGTRGKQQSGFDISRSFAMMTFDIIGDLSFGETFGCIENDKFHPWIEIILGALTQLAVFDTFKRFPIAGGVVALLLFGKIKKLLAETWQNEEMAIDSVNRRIARKTTRKDLMTRVLEKRNPAEVSDTQLAAHAADIVLAGSDTSSTALATTTYYLLQNSKTMSRLQHEIRSTFHAYDEICDKSTVPLPYLKAVILEGLRLVPPLPLGLPRNVWKGGAAIGGHFVPGGTIVSTNPLAATLDPANFTDPMAFKPERWMGQANGDNLEAAQPFSVGPRSCLGKTLAWMEMRTTLAKIIWMYDLELVDSSIDWHRDSEMRTLWHFPKLMVRATKRAGKDDQNGGDIIAGHYGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NST1</accession>
    <name>A0AAE0NST1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_469031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NST1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="97" mass="11502" checksum="FA80C10053DA1B8A" modified="2024-05-29" version="1">MRRWGRFGHLYPWILTIFQPVHFFGLYSLQFTSSSMCSVCLQLRRHFLRADGGRPASRSVLTPSVLNEHRRVPYSLKKQVYLISLFQHIKIWERPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT10</accession>
    <name>A0AAE0NT10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gastric mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_151075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT10"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111620" checksum="F215B246C8F85A03" modified="2024-05-29" version="1">MAKSPRDHGNIIAFEGPAELVSAQLRLLPTSPQIMILPNLQHYLLGDSNQQPFSVRHLIYQIHKASKTRHAAALEFLRPSRADKKRIIFLDGGTVGAHSLCLSAISKHYTNGDVEKAGSIFNKLASNGVAGLVRGRPTTLSSANDASPQLEKEPRSSKDPDTQATGTRGSSGKKRKSVEEALLESEHDEVDDPIIRAMRAADALYLETECLQPPNHDVDLTSRSTSSSRTRSRRSLSLSALHFAEFLQSSRSSSRSRLTQSYPLTTADNCLAAILQVSATVRPLRTKIPLNSLSWVDEASDVGSSMVSPSSESHSSRPQTPDRLTRREIRVTGVRLLPKQKRTRSKSLERSFLDSEDERSLADLILQLPAERTSRSGSRGGKYQTSCRSSVATTKSGSQPKSTDSNSPDAGAEKAPTTPSNRTSSQPSGEPRSPDTSSDKLVDATDIVHEVLPNAGLSAQQQQQQQQRLFEPVLPLLEDLVVHFSGEAPDELFEMVLQGFRNGANASRTSAMETPGSGGGLGDSESTLKAPNDTAAHRNTILSIETPSELSSYYGVTPPIQTDFIQAAPTLDQRFYNLSVGSQAAVAVQNSLRLVLKSRFPLDNWAYCPSQFSAHMEKESLWKPVFLDAVPRAASKSNRKTDLILAIGAEMGVKREYISTVMGQIEKLGAKTTGLSRTGRLDLRYLIANAMQAFTSQPLTRQARENPFTDSTLLAALIVPHLETYLTLHANVCFLIIEYPVEHLATVLALQKLIGVEMFKVACILNGENPETHDRPLSAPPGLEHERYAAAAGAGALSLPQSPNPESFSGARLFSKANYLLTYLATGSETSGFVAAIRETLASISNYYVPEVPPRKGSLLHNSYMLTDVDLAAKVSKAVRLQTPPPPLHPKTSLSSGILDTPPSSPLEYFSTGKPRSATRPLSPTLSTKSRASLKTPVARGGGSGEEADGSRHVRTPSDSPKDHRLRLVKVNSAPNNYYSRYDGLVADDEDEGDSDAEERRLMPLFLRRQAERGNSQKAMKWLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT66</accession>
    <name>A0AAE0NT66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_469628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT66"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3387253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="102" mass="11192" checksum="581A0E7742D8EB18" modified="2024-05-29" version="1" fragment="single">MVEQQQPPSLTAVYTSGTSGNAPFTITTALPPVPTTTTDDNKSKTQYLLSVREAVIKLQEHVNKELTARMEEDNKKAQAAGAKPIADEKEEKNYGEEVVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTF4</accession>
    <name>A0AAE0NTF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_541715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTF4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="652"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="957" mass="107987" checksum="0260DA6E1B059B0E" modified="2024-05-29" version="1">MTSTISKLEALRDQLSGTMAKNFEGKVFLPDLTCRNIISAADIEGCLREAELGPATLRDEVVSAIQNGGQKLFAILALMQGNHVGLLVNFLSVDHLNTGTLDARLPFQLGQLMEMFGDPVQAASFYQTQWALTSPLFREDRSDRKFNNDTVLPFMTRTLKGSGVSGKVYEVVFHNSHHAFGFAAAHKEGQVRLACKELSTDDVSSEKEILILLRQLRHANMIQLLASYSMRGTRCLLFPLADMSLQTFMAPGDDAGHLIPQYFPSYEEYLDQVLGLSSALESLHNYMDATDGVRMKGCHFDLAPRNILLQKGKLLLADFGASRLRSESSDSATRFKGGAGDFLAPECTVVGFGSDVGGHLVGRKSDVWSFGGLLAVLVVLQASGRQGLAAFRAARRHEGLDLTTWRFHASGRENIQMWDWLKTCNFSPTQQATLGLARWMLTPTPNLRPAMSQATTYLRLVSQRARFRAIDAQFAKLLKARPALKLQIEQERFFCWSCAAGLHVERSEYSPPLELEGEEQQEASWLVKPKHRAEFHTISGILREMQEENSFLITGLDQDNPIAPIYDRLNDLNSKLWGLAPANERVRMLAQLEAAIDRILDARGMESRHVISNLSPSWERQALLLAAMRYMSKKLQDSRRLTPDLSVNPNQIRLAQKVGKANIVYVGNDAHQPLFCEWISYDIHMIDQVADPLVERVEAIARRFAFKPEERPADFNVLHCRGWYHDLPKSRFGLVFDFPPPLEVRLRGNRRPPVSLRELLKQQPRPSLERLFDLVQTLVKSIHYFHRANWVHKNISSHNVVFFPDEDDWSLGESGFPTPYLVGFNHSRPNNPKDFTKGPEGIDKSYMHPEYAQPPEPRFRLGYDYYSAGLLLLEIGLWEPISRSSLLLKKDIEKFTPAELQALWMERAVPLLGPLMGATYKKAVTLCLNDHFLAMSAVQSIEEFNQQVVQRLGHCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTY3</accession>
    <name>A0AAE0NTY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_470713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTY3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="110" mass="12343" checksum="D14B9431E3D33C85" modified="2024-05-29" version="1">MQAAQPSSTCSGLRGGSLWTIYGVLSSILFRLPALAIAFMAPAHRGYLRTPTYSYLLGSCPRLPDRRLLLWSICRQVLFPPPEAYLAKLSDDGHFRLVIVCPRCMCEPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUC9</accession>
    <name>A0AAE0NUC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_166271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF4">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042014684" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="347" mass="37423" checksum="EAF4192C18A42892" modified="2024-05-29" version="1">MHSWATVAAVGLLASGAAAQNMLRFACSQLVVDRIDPLVNPGQRYTPHLHQIVGGNSFNLTMDINNHDLAAKSTCTSCSFVQDLSNYWTAVMFFKAKNGTYKRVPQVGNGGPQGQLINKGGLDIYYIPSGKVTAFKPGFRMLAGNAANTDNSKVTKGNICHRCWTSTNDNTFVGGAPCTGSDTVDIPQDTKCKMIRQTIIFPTCWDGKNLDSPDHKSHVAYSGTGASGGGSCPSSHPVKLPQIMYELMWNVSSFMDKSIWPDSGNALMYSMNLGGAAAHGDYVFGWKGDSLQKAMDKNCNLNKDCPAAGLTYQAPEKYNACNVKQQAPEDVEGWLKALPMGEMAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUN0</accession>
    <name>A0AAE0NUN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_471347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUN0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3388017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="308" mass="33146" checksum="B2BDADC13959E99D" modified="2024-05-29" version="1">MGFDPKTETPHLSGKVILVTGGTGGLGAQSVIKLAQWNPSTIYLTGRNAKGAEATITEAAAASDSATSVRFLECDLDSLASVKSAANRVLAEQSRLDILIANAGVMNHPPALTKDGYEYQFGVNYLSHALLIKLLMPLLESTAARTEADVRIVQLTSTGFRGAPSGGIQFDSLKTVQKFAVFGGFVRYGQSKLADLLLASELAKRYPQFTSVSVTPGIVGTDLVKRQSGFHRAHICLAAKVGGQGGLIKPEDAAWSTLWCVGAPRDEIKNGAFYEPVGVLSKVETKFTKDAELSRKLWEWTEKELEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXA3</accession>
    <name>A0AAE0NXA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_556466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXA3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46833" checksum="4D3E82052CDD3058" modified="2024-05-29" version="1">MAPTARLVVMDPDGDLLLRVGLSSTPDNKGADEGGSEKSPSDVKQEKNSKQDADKDKTADSTQETKKKQKTRKNKKLIASRRPTMELSCSKSALPPCGEGEWEVSFPEDNPEAFIILLNIIHSRFALVPKSPSLSQLYDLLVLIDKYDAAHIVRPWVDDWMNAASAPIGPDLDIYKAAYVAYELGNEKRLSSLIQHVVLNIKPMGSFSRKSTWDESKGILHPILEYSYERPLDLLRTAKMLKKDLLDRILSKFHKYMNQLALNTAGCVGTPGSGFGASSESYSGYHSGLSRRLSSSAKCNAEEMNACKHAILGALCADMMVSRGGILPPSSSGCTDTALKLMASIEKAVRSVRGLPGHEKCAQLDVERFTKDVQNDFCAKQSMFTEAQKKHMEMQRQKTGLKQFPEEVSVGCAWVQQPPSTGGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYA2</accession>
    <name>A0AAE0NYA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxidase</fullName>
            <ecNumber evidence="5">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_492636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYA2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041771596" description="Peroxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="6">
        <location>
            <begin position="126"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="430" mass="46727" checksum="6B5AB1D9E9C65613" modified="2024-05-29" version="1">MSTLKLTLFSSIFLLVSSRINTYTWPDPKTDILEAIYYQQSGYDGRRFGFFVRSCDIGAGNIGPGRTNSAEWVRTAYHDMATADVEAGTGGMDASIGFERDRPENVGRAFTDTLLFFEDFMSVHSSMADLIALGAVMSITACTASASQRPIYLSFRGGRIDATGPGPLGVPEPHQDLATHINSFKKQGFNVTEMIALVACGHSLGGVNGRDFPEIVSVKNDSTNIESKRNFDTTQTVLDNNIALFQRMIDTVPKTVQLSGVIAPISVKPNNIFIAVKQDGNMTITGDIRTTTGWHPYSPAFECHVLSSFTVEVIDDGQSTVYTNGGAGFPIQTDIIPQAGLSCGTIFLGTSYSLNLTVAVRDDFQLQQVILTIPIPIQQAGSIVPRFELYIQTMQRTKTLNGTGYSFRGGLKDIGMPFQLWKGLGSCSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYS8</accession>
    <name>A0AAE0NYS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_519453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYS8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042105921" evidence="2">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="350" mass="38742" checksum="070BC6AEFA57AA93" modified="2024-05-29" version="1">MKLSLVLAGASAAVAAKVRCRDVDAAFDTLVTFGDSYTDNGRLGYYINNGGKAPPPGQYQSVTTKTASGGLSWAQFAAQGANASLLDYAISGATCSNKIVERNFAYIKRSFPAVLDDEIPSFVADVAYETLYPNRTADNTVYALWIGTNDLGFDAFLSDSQAPETTITDFVNCIWTVFDSIYKTGGRRFVLLNEAPLELAPLYALPQNGGTLDSQFWGTKSQYNISEYSNKIKEYSTSVNTIFEYGVPFQVKIKSRWPQATFDIFDVHSLLTDIYYEPQQYLDAPYNTSGYFRHCQATDNSKCTDLTNLGPRSGFMWYDELHPSDKTDSVIAKHFLDVVAGKSTYGTRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ55</accession>
    <name>A0AAE0NZ55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_113119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="287"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="610"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="898"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="166551" checksum="F3C4A99AA6FB03A9" modified="2024-05-29" version="1">MEEALPWAWALTKPGVRQIGLPFVAFTSSGVKWIDDVSRLAKSGFVQVVLAATLLLWAIAEIIKHVTRPGVGSPTTKAPRLRLPFEICSQATRGAALAFIVVTACSDQRHWPNVLLVGYAFVLGLGRLAVNSKWRHLTLHQVNILLSLSLVLLVASDLLPSLALGSAQEATKAEVGAMASLGVAILVALLTPRDWVPPNLETTASCGAPEATPSQEDTCSWFSYFVSFEWVTSLIWQGWRNPIEIGDLPKLPWYDEPLVLLSRIIETRKKHPGTLWTVLNFQRTTIIMMAVWIVMSYLIELVAPFAMYQLLQYISAPEDAILHPAIWLFLLFAGPLVKSITFQRFLFTYSRISVRLKSAMTAELYHVALSSLELEDDVLNQIATTGSKEPASKSTSAGRLANLMASDVDAVAESMYSFGAIVGVPISLIATMAGLYKIVGWTSLVGTAFMFLCSPFPTWLAKTMGGSQQRVKQAQDSRISLVSEYLESVRAIKYFGWEDDMAKHVQEARAKEQKEMWKISILEALFGVSVSAIPVVSLLIIFGLYAGVLKQPLTASVAFTTLSLINTMTGNLAMTSHITRNATEALVSVGRLDRYFSSTSPLARFPEGPLRIEKATFRRGRESSFLLKDISINFVQGGLNAISGQSGSGKTSLLLSILGELILESGSATRPADIAFASQTPWLQSESLRNNILFHAPLEQARYDRVIKACCLGPDFSELPKGDQTEVGENGTALSGGQKSRVAVARALYSKAPLILLDDIFSALDTKTAASLWKLCFCSDMLKGRTVVLVTQMPWVAAQSDLAITMEGGTVISAEQHLGVTRKPVTIELGQARADDTGLETIAIDTTAPILDTKPVGPTGEGQENGDGISDEMKASGESARLSIFKYMIYFGGLLFVFFALLTTILDSTLRVLTTYWLSVWVGAYDKKEPVSVGFYAGIYAAVTFSWVLMSGANFLAYTRGAWLAARRLHGRLITAVLNAPLSWWKNVPAGRVVNRLSRDMASLDTSLGQWLMWTVDQFASILFQIGAVSTILPVFLLPALFAILLGVTCGEIYTRTAVRVKRLVASSQSPVFSQFGDSMAGLAVIRAREGMPETFGSLLAERLRSFERARNANYDCNRWVGFRIDLIAALITLCAGVIAVSKSNTLAAGLVGFSLTSASGMSDSILHLVRCMNMLEVELQSFNRVEEYSKLEPEEKSVEIPSGDAGLLPPPHWPQTGSIEFRNVTIRYDKDGADILKNVSLKFKAGERVAIVGRTGSGKSTLVLSLLRFTEIVSGQIFYDGVDIATIPRKKLRQALTIIPQDAVLFNGTVGSNLDPSGNVAVDVLEDALASCNGIASFHRVRNNNSAEETQSIILVPAADGNTEEVTENTPLLQSNDGSDHTADSATSTLISQAAAGDLSLSTAVLAKGENFSHGQRQVLSLCRALVRKQSKLMLLDEATASMDYETDREIQAVLRKALDHANSERTLVTIAHRLRTIVDYDKIVVMGAGKVLEVGSPKELYRTGEGGHFFEMVKHSGEGEDLTRALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZJ8</accession>
    <name>A0AAE0NZJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_117256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZJ8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30288" checksum="F5AF1D89707FF2A3" modified="2024-05-29" version="1">MRVLRCVPSRISLIPTRTRHPSTNLWFGSTRATTFIQRNFCDALERTQNSNKTDDHDAAPAGAAALAALIYPNAITSSHHDLSSFLKYTEQSGLHKESTLFVGTHFEYTVENVLRSYGFSLRRVGGASDSGIDLLGTWCLPSAFSDGGKEQQPLKVLLQCKASKRPGPHLIRELEGTFVGAPAGWRGSRVMGFLVTDRPATKGIRDALGRSRWPMGFISCSRTGLVQQILWNRRAEEEGLEGLGIGVRHSQSSAQEGVPAEQKLLLTFNGNHQPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0F0</accession>
    <name>A0AAE0P0F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_130242</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0F0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3391021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="444" mass="47925" checksum="2D59E4E7A2BBAFB5" modified="2024-05-29" version="1">MAAPNSIGPALLAANKSLARLDLDGHDLPPSPAPSSPHAGRRRYALATELVYTETKDQYGSSSIPIYQSATFKQTSSSGGNEYDYTRSGNPTRTHLERHLAKIMNATRALAVGSGMGALDVITRLLRPGDEVITGDDLYGGTNRLLTYLKNNQGVVVHHVDTTNVDSVRAVLSPKTTMVLLETPTNPLIKIVDIPTIARAAHEASEKVLVIVDNTMLSPMLLNPLDLGADIVYESGTKYLSGHHDIMAGVIACNDPELGDKMYFTINATGCGLSPNDSFLLMRGVKTLAIRMERQQTNAQRIAEFLESHGFKVRYPGLKSHPQYDLHWSMARGAGAVLSFETGDVSLSERIVEAARLWGISVSFGCVNSLISMPCRMSHASIDAKTRKERQMPEDIIRLCVGIEDADDLIDDLSRALVQAGAVTLTIDGFHANDADSDSAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0V9</accession>
    <name>A0AAE0P0V9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_389646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0V9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="232" mass="24960" checksum="547CFD8032DAB626" modified="2024-05-29" version="1" fragment="single">HPSDVADFEEYHQHLPEQWCPMVSVIGSVPSCEGNSTDPSEACHFIVETSVYDASKAAPIQFSVVCFLENTKRWQKVKTPASGASLSVTAKLAGRTTDTNHLALRVLDLAYLPRLNSGAALLTPATTPPSKRSRWDGRAPSSTPSEKPRTLEPVNGITTLSDRDTTPPKPAQAESNLPPSGDMAGSPFVTSSPSTAANQEDFSVDSIPPLSSDSATRPHRSRHPPKKYTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3J3</accession>
    <name>A0AAE0P3J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_405822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3J3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3392758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="985" mass="109987" checksum="6910996455A7C4F7" modified="2024-05-29" version="1">MTGDDTSSMDGAAPGESPNGGPSTSALGSQDGYDVQQIQDLARHPPPGASVYSPSAPVSNILNPRSCVTCRRRKVRCDKHMPCSNCRRAHIPCIFPAPGRAPRRPRPKHPSAPSKQPSSERELELVKRLRKLEGIVEELSGQIELETVRHPMSNSNSPEAVAESHDVDHHDAGGRYGAGDSAVSVNGSNNSQDSPIPSASVALRPARPAARVEHGQNSHPGPQRAISSDVQKQFGRLVLNQKGGTRYVSSGFWSSITDELDEIRRQADNYTDESHESDEDVIPEPTSQDTRALHDHQSFILGYRSADVDLRPLHPLPSQIPFIWQVYQENVDPILKVLHVPTVTKLIRGLRDNMDTLTPATEALMFSIYYASLTSLDEDEVRMNFGADKDDLAKKYRFALEQALAKANFLTTPDLMVCQAFLLFLVIVRRHDDTRFAWTLTGLLIRMSQALGLHRDGSHFSNLTPFEVEMRRRLFWSVLVLDLRSAEDQGTDLTLVDTTFDTKLPLNINDSDISPDSKELPASKDGPTDMTFSLIRYEICSLARRLHTASSASAPVCPRDAASSLEEREALLLEKYDQVHSKYLNFNYDDNPMYWVAKNVTSVILAKMRLVIYQPVLFPGPGNGWLSPETRARLFVSATEIFEYNHLLNTDPRSKQWRWLFQTYTQWQAVAYALIEVSHREWSASVERAWAALNLVFSTPKPLELEKIADHMTVWLPLRKLYLKAKKHRDAEIVRLRANPQDAEELDLEDRRNAPPQSLSALPASMKCSIANDRWRKLINAPPRPPQPIQPPKPKDSEVSPPIRRTDTSGTDQGRPNTGMVETPEFMDYVDAAILDPAFNPQNFANLWNRDAVMHLGGPSMFAFAEGDMSQHMNAAPAESTSLYGASTTMAGPLRTMTAGSSTSFHHQHQHQQPSPAFSRDDLPPWLWSSNTGADDAIRVPNLNHVEMDVNMDEGFDWQNWQESLGRFEMEANGGAASGAWMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3S5</accession>
    <name>A0AAE0P3S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_530207</name>
        <name evidence="6" type="ORF">B0H63DRAFT_540073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000020">
        <property type="protein sequence ID" value="KAK3365439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="100"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="518"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3365439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3392761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="136377" checksum="775E427100EC6F59" modified="2024-05-29" version="1">MARSMFPSRHQPRNKSHPTMAISTPKTPETLPAAAEALSECHGQKLLDLGQTLWAMFSNTAIKFPDRDAIVSMWQTHDPPHDSLNGVPPSQDSTPSKPQYLRWSYKDLHQRSEVLAAWLESRGCQPQTRFAAFLWNSVEWGLFFWVSARLGMAYAPLDPRAVASDGDFFVKAIGPAVVVAQDADAAAALEKKMSRSHEGSIIRIQCSGEQVSGWTLLSQIWETSTASSLDPGNEMAGPASQGANSSSPEDVALVIFTSGTTSNPKGCVHTHSNLVAQTNQYDPNPDPSVPDRWLVHTPVSHIFAVNNGIRSWRLGDAVVFASKAFDVQSTLRALIDEQVTIMSAVPTLVKALLANPLFPGKQALSLSLVTIGGTLIGPADIRLCKDGLGARHAVQAFGMSEGAPVISWTRPDPLLNYHDGYHPGVGKTLPGANIRICVPGTRDVVARNEVGELHIGGPPVISQYLGGVGTDSIYTDKVGNWLATGDQARMDDDGVVYIIGRYKDLIIRGGENISPARLEAAIGEIPGVLAQVVGVPDKFAGQVPVAVVKMPETVSKKDVMAKCRELGPMFALSGVYLLSDLGMEAFPLTSIGKVKKEVLKKAILDLRSPNTTAEPRPENGCLVAEKVMPTVDTILAKKPIKTNGSANGVKDTLADRLALLWKELIGEVPLPDDSISLFADSITLLRYCDRVLTSLGQRLHLQDFKDNDTVAKLAAVLEERSRATASFQIPGLSEGTTSHNMINLLTNGATRKPGQNTAYKIRDGTVSREIDLYRTAAQAVTEAGFQPGDIEDVLRIKDSFHSLAIGAAPQSNQDRMIFRVLGDVGVAQVRRGLEVGLASRPILRTILAQLSDDTPFHVILRPGQRLLDSVIQEIETTDDDGLDKINQSASNPPYPFMAWFQIIMVKQTGEIFLSATYNRSVFDSRSILPWHLDLARFIERPTAAVPPMTPFKMFAELIHLYQSSVPAQMAVEHSVARLRGISRLTDAFWPIQRAPGWMISDDSGHPLVEERALARKDVWKGEWDEARAEEFRFARMGRLLPLYGLDNLLAKLKVVNVALVMKAAIALFNVLRTGAQHAVFNSLQAGRSWPFLPPWMEKGLMLPPPISIDGPTSEWTLELCEVVRRGETVAELLLRMRNEQELLEKHAHAPWFQVLDGLGDEAEAAVDASLRQSFSWELGNGMPKGGLAWNAFMTDRLYIFFSASWDTAQMNVGEVEEHCETVASILRRLVAEENLDRKVVDVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4S5</accession>
    <name>A0AAE0P4S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_13815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3393227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="376" mass="42007" checksum="32CB33148623584B" modified="2024-05-29" version="1">MGLAGAKNKRKLGLDPNNTKWSRNTDTFGQKLLRAHGWEPGQYLGAKDAPHAERYTEASNKHIHVVLKEDNLGLGAKRNAGDECVGLDAFQTLLGRLNGKAEDVLESEQKEREAMKINAYLHRKLGTIRFVRGGFLVGDEMKPTKESVETIPTPSAGASKDSASEGTGKSESTDRKSKKRKASEDTDSSDSDSDIDSEKEAKKARKKEKKSKKRRAETDAETDAEAARARKKEKKEKKEKKEKKRKTEEDGDDVDSSLSDAKKAKKERKERRKERRERKEKRREKGWKEKASSDSESEADDSISREKKRRKSKGDKSAASTPLECSTFTPGGSGTSTPVPTSIRFLSRQKYIAQKRMAFADPAALNEIFMIKSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4X0</accession>
    <name>A0AAE0P4X0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_406424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042194692" evidence="3">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="36336" checksum="5564BC3B304C555A" modified="2024-05-29" version="1">MKNLSVIFPIAASIAAFVLVLLALLAGQNPGFMEDYDVISFNTSALGKNLVLNAAKDDEPTPTGGGFCSDLPGFLGKGCATATAAIGSIESAIVSEVNDIANDIADHLSAELGIHQFYSLHALSICEGSFSPNATANGATRNVTRCIKGATEGYNISAIIDHQLQIGPFELGIDDLGFDDELQSAMDTLNSAIKAFVILLSISVALTGLSLLTSIAGFIRYTRPVLIVNVVIASLAFIMLLACSLVITIGARKAATEVTEKGDDIGLYATAGSKYTAITWAAVGLMFVTFAYWLWQVIRFKNGKTDLHRQTKRSPRDSEEAGAEKPNLHGIRFSKGRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P586</accession>
    <name>A0AAE0P586_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF1640-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_498652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P586"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3393482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="293" mass="32859" checksum="62E5553986C4DD91" modified="2024-05-29" version="1">MNATQSVPRFLLPRLSWTGPRSTVAATATSAATATSLPRLSAAFFQQQSKDHRLGAWQAAGRPLHTSASNSRPRTHTPRCADNSSSQQPARSLSNAARSPSLRRAFHASAVRSRDHHFDTLKFVQRLEEDGFTEEQSVAMMKVLNDVIEESIQNLTRTMVLREDAAKATYTQKVDFAKLRSELLSADSTESNTTRAAHERLTNEIAKLNSKLRDEIGRNQASVRLDLNLEKGRIREEAVSQELKIKETETKIEQEVAALRQQLEQVKFQTLQWLMGVCTGFAALLLGFWRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5Z8</accession>
    <name>A0AAE0P5Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_459623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5Z8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="161" mass="17158" checksum="BCDA70CCF5A91825" modified="2024-05-29" version="1">MSTNPMNRKGHQPGHNQHSSDAPEFHAQTLPAGTAPKEHLFRPPHAQNPEIDPSFHPGPVDFPGATSKDVYADSAFGRPMEGQTGREIFHAGGTDGKKIRSGLEGRGSSGDSRETVEAKARATRTDIPEEIGPGIRGQKTAGATERIPVSASELASERAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6L2</accession>
    <name>A0AAE0P6L2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_460502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="423" mass="45948" checksum="B29FF32C88B7FB72" modified="2024-05-29" version="1">MATRLIRAATAAANAADRKSGALAAGSIVSKAASASKSSFQPRQTFEVSDSITRSYFLGHHHAALGRMRQTLNHIGLIIECRDFRVPLSSWNPLLERSLAASPSERVRIIVYTKRDLGPHSRAETSNSRRKLGIAPSGAPRQSGPEVVEILTQFHKEKQHAAAVTFLGTDRWDTHAAGDKLLLEAIKKVAREKDSLTGLRAMVVGMPNAGKSSLLNRMRMAGMNLPKAAKTGAEPGVTRKLGTPVRIVPGESPEDPETHGFGEGVFVMDTPGVFVPYVSCAEDMLKLSLVGCVKDGVVGGVTVADYLLYHLNLVDPTLYRRFCPEPTNDVYEFLRGVARRTGKLRRGGEFSLENAADWVVQEWRRGALGHFLLDTVTPETLGLAVEAAKEPAVSLSQARKKEKVDRKIKNEAKRASQADPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P710</accession>
    <name>A0AAE0P710_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LETM1-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_47754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P710"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="253"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3394499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="551" mass="60682" checksum="BF81292EB6052DA3" modified="2024-05-29" version="1">MSASASVARRAMVVNPFVGAVSSSGRVLPRSALLTTSIHLARHSQNLVFNNQITALLIPLRSLTTGTSTHSTGPPSGPPPGFNPEEAKKPLQRDSAGAVKAAVKPKGTEGEVKEEDEKAGSSADDATSLAQLDAQKASVLEKTEEKKGEKKLTIGQKIKKEIQHYWDGTKLLATEVKISTRLATKMAAGYELTRRENRQLQRTVQDLGRLVPFSVFVIVPFAELLLPVALKLFPNMLPSTYEAQKSRDAKASTLRATRKEVSDFLRQTMKETGLPLTPATAQKEEFANFFRKVRATGEKPTAEDVIKVCKIFKDDLTLDNLSRPQLVSMCRYLNLNTFGTDMMLRYQIRHRMRQIKADDRAISYEGVDSLSVAELQMACAGRGIKTHGVSPARLREDLQTWLDLRLREGVPSTLLVLSSAYGYGQAQKEGEVSSQIEALTGVLSSIPEELFHEIELEVHNAEGAATNKQRLEVIKEQQELIQEELEQDQENQATGFATPRDTDDIDDKEERQMHAEADGVSKAQVSEAVDAEQDRVNAANADKADSTKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P814</accession>
    <name>A0AAE0P814_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_533600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1774"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2822" mass="318626" checksum="3DFBE48E55E5118F" modified="2024-05-29" version="1">MASFLQPPTSGDPVIVACNNSNTTSHHWQVYCNRLLAPEERLKTPLQYFTLVFAVTCLVLPVGFSFITSAYRFIGRITRDKHLPPCSNKHTPHSSSPIDCKAINSAHSFRFLDEDASAPSILDDLSDQTLYITPLPSLAHAELDHISISACARPPGRVFGLLETNHLTRTTSAALINILSNLVHNNDILGVVVRDDGFQEDIGEPYPLLELLWQLHEREVPVLLNFNHDDDGLSDHVNFGLLAGIIINNACVLRTGERRDYFQSKRLREVMTKCVAERAQRAAFFVGFHDVWDTLPSAAVVCRAEKLARHFEAVFEHGPSKDKIPDMEPRYRSAMSRSTSGFEFLRKPETCDLQTAWLQERRKVHVGPYTKTQEGEIACLDLDELRSVFPDIESLLDPLPLSGDFEALRTETKPDISPPQYVNRAPPRVDFWEVTAHGEQISMAGCVPLCSTATAVQYQAISECQTHLRDLNMLHRFDEAENNKLLEQLRQFQSTSHQQYLIGSLIDGLVQQKVVVYKGLGTGFTLPDNAAEVWGVSTATYAETGGFIDIFISRRCQSDVGTILHTWMAHHGVARVQRFEEELRLEKVTDPAAHNALPASIRTAIDRATPTETLSLLQQLQVAQFEHPFKDAIMHYCKTVLLDETSLASWNDAHCRQYLDGSVTMRDLLERRLMDFIHMGATNLPLLERLVSMSNDVETLINRSLFNGDSDAINTITNALLHAFDPLIAWNDCMFVDVNSNLVALMFFCSLRKAALEDVYFEATDHCPLFSQLDQAAVFSELWVLGSQCELYFGMKPRSLGKIVYEKHRAFLIAHPPPELSSQKTGLMTVYAKPEPSTGSSEMDPDGPSRQGFKVYNAIQRLREKTHEFGALSIFCLPAILDLLLLTFLGRGMFMTAFMGDEYLSAACYGLLLSLLLSAGVTGWVGSVGNYYLCNYAYNSMIYFHVQRLSGGFALSLVVGIVGGVVFGLKVSVGSALTFFAYLLLISTYLYLLGIMATMHQQGSPLRSGRTVLWRTIPVLFLSPIISTFINGHDLKIYLSVGYGFLITILAQYRYLCHEWINWTDNIPKFNDKDIVEWYSLRLDRQQLSDDSTAESITGVSKESPEVFKRLALQAFRQSVDSRQKGLFNLRGRILVPDPLVRRIESGLPYIDWLFKKEAEGSGPTELFSVSWFAQLSQALKKQEQMAQGLKEHSILMLFRYARFDIGQNIGLFIICLMDRWVNITMAATFPSPSVFSHFTSRYAICLSILYFCGSVMTLDNTLRNYWTVSYELSDEKLSSCEEALLVAEKWERNRRRQYVSAFLKLGRHLMFIAGSATIFVWVLVDSALMQQLYYAYILGYSAVIIFQFNRCFTTNVRFHVASIFISAAVGFVTGCVLHAASENGALFFADVIALDAAAIIGAILTSIWAFNDFKVAKNTASNSNPDIPRVWKQFKLTARSASLTHSDARLESLQGNLLEGDATSFSQGISELLQLSHDQPSEHAATAPWAVRVLQTTLSLWMDNRIRVSTMSRSEFLEAGLEDLVSFATYENEILHVTVGLLGEDELGSLLWQEVSIRIATECILFHMSRTILGLNLNQATQAEFILHATGELSANLELQIATQDVAELSSIQGETNQKLLQHLCFGLDVDLEWDHLPLAPRAAILQRVIGEPISMSGDLCRWFKRRSVDLQAGDFHVNLCLLIHGKAEERLNTSDTEVSPAHFQRPISARALARTGTCGDTSGLIAFVRRRLFKVPVISSKWVAIISGGGANIERELWYSLRHCRQIRGISLWLLLLVLQLCWHMKNAWIYAMLVYRHNALVNISRLAKKGTSRTLHKNRIVVEFRRRTLTGFATDTEQGALGLEIFDGHLDERPTGTDSRHNPIAMAVYDDRFRLISRVEDKKECQVKMTYTYTENSKSRLPSSKQILNSDGEIKETCFYDKKGRVTHGTAKFAATEYSYNYFYKSNPKGSQEVLKAEFQLANVASSSSLTVFWGTPLREDLSEKCNWVPSDRVCRVVRMQGVKRYTTTSDYQHRRDPVMMTVMEEAGSRVVVPGPPRLFEHEESLQIRPSDVSFEIDDLFLHHRVDHIKRIERMGKGKKSWSSLFNPLAWQHWQRKVVYRPLPTWWLRTELWNHWRNSGTLDAIAACWMDELILREEPLLRGYWRARSAGQLSKAIAVLDSQIEQIVSAIEIEKDVSEVCLLPIKSSDLYTMGLGRDGNQLTTRPRDCFKDTTDRISVIFNDIGCWPDAPGGVSNCRRDLVNGHNTIRNHVLAETANEYGIPRFQVEKSVQSLKMLPLWGLDNRTPNHGVIDNLLETQVDDKISNTDPGKDIESTFVPLLRLFVKGARSRHISRQDMIKYSDAMLAMFAYFERKDYNETWNSREVLSAWADAWLTRHDDPDIVDPGDYFEIEKPSMSDFRGALSIYSSYFFIFSVQTPEDCPKVFQSTHHGISSLFGMLLKYRRGATFGIWDHAILWRECCLNISPAQSALPLPVQSMLLAGIGLAMKLAYFHADVVLPCTPVFNPIWEAELGTDSNRLGHRKGFTRKIDPIVNGVSNMDAFKPVDEVRTETPTVVMLSNVQFIKDIKTAILAADVIVNKFGFSDYRLFVYGARDREPSYDIDMTKLIESCNLTDRVVLKGFGKPHEALKDAWLFMNSSLSEGLPLAIAEAALAGVPIVATAVGATALVLTNPENPSVRYGEVVPPNDPMALARAQIAMLAMAGPWAKFAGDVDKRGSVLPHLLMPDTLTEQDVKWLSKRMLEKTEARRQLGMLGREMVLRGFHGKRYLREHEQMYWIQWHLAYMRMNPDLQPYIPPGEVRRRDLVQNNARASLTEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P815</accession>
    <name>A0AAE0P815_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_63899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P815"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="37997" checksum="25EDDA88CDA8C4B3" modified="2024-05-29" version="1">MGLVEDFPQDPFFPSLRYAATCQAPVRLPWAKESIMLGTSLSVSRQDAVKSSFLDKSLSALSKESLEQSQLVYSCVSRGSVVTAETKTEASSHEHSDYSISASIGGSFLGASGRVRYERAAASDENRIRGSFRTRYENGMVSFQDEPRLSPAAVALLRGKDGQAAQQAFRDKYGEYYVAGYILGGANATMVGVSTLESAESKDMKATITIKVLFIKKSIHIEKSDSATRALGAASLAAYDTLAGIELTVAASAQEETNKREVDPNALASIAGLIDTALDNQDRGWNLVERVEAKTGQMGLDTSGVVAAAGRLPISREQCDQLCREGLVVELLLLPYAGLRHYVQTYYSVTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW18</accession>
    <name>A0AAE0TW18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_524283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW18"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3381578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="61" mass="6984" checksum="38AEAD1339F6A3D1" modified="2024-05-29" version="1">MPIPFETLIPYGIIMAMFGVTGAGMSKFRHMQNGGKRQRRSIDQWDRELPIEGMPITKMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TYZ7</accession>
    <name>A0AAE0TYZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha/beta knot methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_494012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TYZ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3384741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="260" mass="28751" checksum="D944833F00155B69" modified="2024-05-29" version="1">MSSSPEYRAGKRPRTQSLPPPALPQLVAEQHMAIPPTDKDTKRLIVVLSNASLETYKASHGASRMGVQREDKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPINKAGKLQIYIQTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIKGANSQEKLLKVIQNPITDHLPPNCRKITLSFDAPVVRVREYIDTLGPNESICVFVGAMAKGADNFADGFVDEKISISNYSLSASVACSKFCHAAEDSWDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZN2</accession>
    <name>A0AAE0TZN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZN2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="84" mass="8780" checksum="1003109776DEECB9" modified="2024-05-29" version="1">MAEEERIVQKVEGALDGQATANETANDPSGKEAKVDALVDSALDEVAIKDGVSAVLTPELNNLVNDEVNKAVSEVINDGETDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZU4</accession>
    <name>A0AAE0TZU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZU4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="368" mass="41895" checksum="6527946BB425E2F5" modified="2024-05-29" version="1">MVELGLAILKSQRGLKSMSPSALHTYQKREFPESKLGSEMTERAERFVDGLRSDFPKTYKPNNACVLHINEQNVSNYVTAKEKKDSTNEYRYLFLIAVKVAHQVCHMCMRCHTASSPVPAGQPKEVEHGDIWERFMLGGRLVMFEDLDDFPKKQAGIPFIIMPLRSKYCPDYTKEAKEVSHDFVSRVTSRPLEAIPVPGPEVYNPQHFEPYYAIDKSKESTTLEKLYRYRRNCCDFRTLNQIPRRRSGESSSRDPICDAYGRPKHGPEPKCIRSRYNAKVSEPRPDAITRTPSMSGSTTGAFTDGLLGDETGLTKSDRDLIVSTHKLPTSNHAASEDDHRETWRGDDFARDRSEARSLPRAQSRSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZW8</accession>
    <name>A0AAE0TZW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_395282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZW8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="280" mass="32249" checksum="D04FFA908663BB4C" modified="2024-05-29" version="1" fragment="single">MPPRKCCTEEPLTIQDVDWLFDREFKEAWNKRYVDHQQSLWRKNHNNRAIEIVDHHSRDEVPLPIKIRDGDDGKEASTYQTPFESQGEPSNRPGSFDWRATQKDQTGYQEPPALSPLPSFLDKSSRNKAACTSDPDEESETANITTTPLPTIVDGLFNLPYVCQFSDCTAAFQTQYLLSCHANIHSSARPYYCHVPGCPRSEGGKGFKRKDEMIRHGLVHDSPGYVCPFCPDREHKYPRPDNLQRHVRVHHIDKDKDDPMLRDVLSQRPKVPGGRNKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U052</accession>
    <name>A0AAE0U052_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_433959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U052"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="37"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3386108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="50223" checksum="CB4E7360819E6330" modified="2024-05-29" version="1">MASSIMPLDKLLGEKLIDRAQRHQYRELTQIKPGTLTDFSSNSYLSLSTHPTVRADFMRRIMHRYQQSTRSPWPANRLLGSGGSRLLDGNSPLAESMEKDLATYHRAPAALFFNSAMEANTGLISTIPQREDVFIYDEFIHASMFHGMKLSKATLALSFAHNVARKPKEDEYKDLGIEETSFSSLEEALQHLLTGHGCDWFKKGNRNVFIIVEAVYSMNGDVAPLRKIVDVVEEYLPRRNGYIIVDEAHSTGLFDRGAGLVCHLGLEKHIYARVLGFGKAIDCAGGLVLCSRVVRAFLINYSRSFIYTTAMAIPSLISIQAAYTFLVGKPEEAKELIQQVQKTTLFHVSPDEPQAPIVPIFTCRPRSLARHCRASGYSVRAIVAPTVPRGTERVRVCVHASNSLDEVKGLCTAIEAWILSQLGLDEDDPDEFNSDDSYSDGGGSNGPAKKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0C9</accession>
    <name>A0AAE0U0C9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_434083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0C9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="234" mass="25804" checksum="AEAE3C4BC92FD3D3" modified="2024-05-29" version="1">MSKEPVSPLANERLKLTPFLAERHADSYFAQTAAHPKLYAHMPLGPFESKADFVSQFLDGMIGQKPGWAAFAIIDKTRPASAEDDEGELAGMISFINTSDTHLFTEIGGVLIFPKYQRTHVNTNAVGLMLQRALGSPQEGGMGLRRVQWLANSMNAPSIRVAERFGFRHEAVLRWHYVFVDGLKKGKVGNGRPLPPGSPEGSLGRDSVVLSLCWDDWQEGGAREKVEGLMARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U147</accession>
    <name>A0AAE0U147_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_541355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U147"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="358" mass="41609" checksum="092A0842798D5421" modified="2024-05-29" version="1">MSFNPLACVIVGTWFGQLGCHAKQDSILDGVGSNRPLIIAFRKSTFINSVIGQERLKIGQDIKSCTQTVDMVDIKVEDCVIRLIDTPGFDDTNLTNAEVLERIVVELGIQYKTKTKFADILYLKDITEYKMKGPDVKNLQMFRALCGTDGLEGVTLVTTKWNTMKEDNMAVAERREKEMLSEHFDTMMELGATYARDYGTAGSARRIIRDVLQKRKESHLPFQWEIMDQGKTLEEIDAGCILMKELHDERAKHRKELQELQESLITEHDEKLRKKMEYEAVKLEKRLRNWEEDRQRLLNNQAEQMDKMEKMAEKKLEQLRKQNEETIRRLGKEKTEELEKQQKIIDETLKKKKEGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1J5</accession>
    <name>A0AAE0U1J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_158613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1J5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="477" mass="51586" checksum="378836A9B3822FFF" modified="2024-05-29" version="1">MQPQFFNVINDELRGSEKTHAVTDPRTEEALWPCPIATTDDFQDAVTAAQEAFTTWSRTTVAERQELLVKLAKVLEDHAGELTEILARETGKSQILASIDVHASVSQCLYYSKTALEDEVQYEDENTRVVATHLPLGVVGAICPWNFPLILSNIKVVSSLITGNCVIVKPSPFTPYAVMKWVELSRGVLPPGVFQVLNGGADLGALMTLHPGIAKISFTGTIATGKRVMASCAKTLKKVTLELAGNDACIVCPDADLDKTVPSVASGGFFNAGQVCVASKRIYVHESIYDDFLSRLVKEVEGTYSIQEDHKAPSVFGPVSNKMQYDVVKGIIEDCKANGYNIVTGGGGDDKTAAAASKGFWLAPTIVSKPPEDSMLVKEEQFGPILPVLSWSDEEDVIKRSNLSNAGLGASVYSTDLAQAERIARRLEAGSVWINQSERPNFGAFFSGMKDSGFGGEMGKQGLLSYAYTQCLHFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U288</accession>
    <name>A0AAE0U288_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U288"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="313" mass="33930" checksum="1BE08134CAA13EB0" modified="2024-05-29" version="1">MRQTNANAEAASANTSSVLTLTPFAINMGNDRRNGLYQFLYPSVKSQKSRAKSLSTSSRQPAYYNISDNVGANIFMTIPESGESSSHARRSSSSQRAHKDNEAASSAEDVARLMPQPPPLPAIWPGFPLVYNNNHSSAVNSPTPTSHQTAVTPPQLPRSLSQRPALPPELRNYHSGVGLLRGGQPFDSTGLFMTFHQYLALSDEGLHCFVPAKPEADLEPSLFLSDAVTERLATQFRIVDRTAAGADGAGFTVVCPGCDVQRMIEKFAPPLGQKRALVHYGRYSEGPPEVIPGILGRGQRFWVEIVDIPATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U374</accession>
    <name>A0AAE0U374_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_95202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U374"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3389181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="182" mass="19418" checksum="82C01329BF9D6A1A" modified="2024-05-29" version="1">MASQKRMARELAQCTATPPDGMTVALANDSDIHNWHITLDGPAGTAYAGGKFGIILRLPDDYPFKPPVVTFATRIYHPNVTNDNAGSICLGMLKPDAWKPATKLFAVLAAVRQLLEEPQPDDPLETRIADEYRQDRKEFEKNARAYVLRYAKGPVKFDAAPAAGAGGGKESSGASGGASGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3K4</accession>
    <name>A0AAE0U3K4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyoverdine/dityrosine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_492469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3K4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="485"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="647" mass="72831" checksum="C3255FAA23B35B33" modified="2024-05-29" version="1">MPAIIESMEPLQPPVVLDKTQSLIQKACDILGIISRYRLKRSDTSSGKYHLAGLKFVALIYDQIKSSQPVRMCLPAFPFKSPNTQSKVLGRLPDMAEEFALAHINGLCAAIGDIYPAGAELTIISDGLVYNDLLGVPDKEVWAYGQGLRALAVEKRFKNIKFSRLDDLLHTNLADDLSEMAYVANATDFRRLLLNNYGKPNWDSSQEISNNEDTCLTYRGYLRFLETDLEHVYPVGPDRSKSRYKNGIKYISKQMLARGDAFARAVREHFPTHIRLSIHPSSTSQSKLSISLLPTTSVWTTPWHCSMATMMDGTVVTAPREQFDNKPDRFELVHNEHGRPSYYREKSDLLSWGDDNNNAANKIISEPLYPCGLLIRPAAGPLALSIEDVDAKRLRALSELNSPVVLRDFARTDDRELFEKTAGDLGTPLPWWFGLVLEVKDQGQDSPQGLGSTLSMEKMPFHYDGVFRTEKRVAADGMEEVVPVPPPKFQFFTAVTPSPQDTGYTMFASSSLIFRYLPPTQSLDVLKQLTFTVSTHAFQANTLSGLPLVLSHPTTGKPCLRFHEPWPRSKTNFETMDVTIKGGGIASEEESLRVSEEIVALLYDRRVTYWHSWKKGDLVVNDNVSMMHTRSEFISGSDRELWRIHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3T4</accession>
    <name>A0AAE0U3T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_464414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3T4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="455" mass="48485" checksum="3633DEC658E2B315" modified="2024-05-29" version="1">MMGRFRGGSALFRKREGLGSRPKIHRAMVKERGSGSENRLNRRQPPFIPPGLTEAPPGGKGKFFTEPPPFLRTPPFLTTPTTSTGVISSSAPVETFSSSTSATLTASSATAETFSSSTSTTSSTSSEIGSSTTLASNTSRAESAAASILIPTTRSVVADVQSTITSFTTETAASRAASVLNSEANAPQGGLSSNQTAGIAVSSILSFILIVALIFFFWRRRFVDSARRRQLGRRYDLGKRLSSSLDGLVEDPPFIGSQAGLIPVFNNNASTHSASQTVQVEKPKPTLSRWVTQLKRIAPQSLSTMLEEEEKVSRRDRIRTMKPSGWPLRSIFSASGLGSSPTPASSSHSKDFPSAAIWGAPESVVSDISSVWTTPASPATHDSDDGFFPTTALRHPKPPAIKPVPTEMVEETTTPKFLAFDPFVDRLAPSSPAAQSTISERSSFDVRPAKASSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3W1</accession>
    <name>A0AAE0U3W1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_445832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3W1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="511" mass="55234" checksum="C95A16C1617311E0" modified="2024-05-29" version="1">MGLSITVDFKGIEKIEDLMTLQTSRIQLSIEGLAVAFEKPPTTRLSGAFYRFSDKGFHGYMGAIEVSMGAWSAIAQGMYEQSDSVESLFVFGMAKGPLFTIGCAEVVGLTGGFGFNSHLTLSGVEQVPDFPFVAMNTNRKNPAEGGVLGPLLETTGRGIVTTMADSLWFIAGLGLRAFQSVDAQAIFALDLSSEPKFSIIAQATAVFPKNPTAKASEVDKAFLVLELGLTPRCLILHPSCRLTGGFALAIFFDGSGHDDFVLTVAMGGAWLDIVLNKSWVRAMFRAYADFMRFHPFEFEADLHATLNLHGPPIAGTAHLHLWRWDVTLCFGAPRTKEAELNLDQIIRMVKNLQDGQSDDLVPNHVLSLKEGVVLAPSTKPPSPDEPIQARGAGFRFEVATRVLVTAVQIGGGDVSFVEKEVEGGQKVRPQLLAAPMQLDSAVVRSGLRIQMPPALWGAHTNSAADAVKAWGKFKRHTSNGGKHRDETDAPMGGGGRQSMKYSKSRTTGDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4U3</accession>
    <name>A0AAE0U4U3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_519863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4U3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3390655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="460" mass="50157" checksum="E9845FDBEBFFA8D1" modified="2024-05-29" version="1">MEQVARRNAGPGGVKAKTPRPRAARRPACLACQRNKLRCSGGPHECDRCQDRDIDCVFAPTARRGSPRTAAVVHAESRRSQSLGPVADDTPAQPSSSRASHPEETAASDQVQGDFVGSDSDFSGFGWLLPASPRQSSSGLCTTVPMVEGGPTGSLGLDESLGCQVNRRQFSPTDSLGSYIAAALGESHTLPQGQPHHDNQETPIQTETPSTGSTSQTKPYTPNCSCLEDLMRIIQQFADDRFHLTSLSLDQVLQIKKWVVFQCCAPLDCSRCICPNSVHTMLLIICDRLTEMFECIHKRIKRSTSAMTGLPLGDLSIQPATTPSTDSLARSPVPVLTSTPFFSSADDGLPPRPPQIFCANSKGPAYLASCSSRLFSDEFRSQYSDEEQVHIIRVLLKLQVRNFRQLLVRVERSTQTQESLARKYTVESMMGRIAKSSADIDEAMHQVLQAISATPMLDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U528</accession>
    <name>A0AAE0U528_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">B0H63DRAFT_389990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U528"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3390895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="135" mass="13974" checksum="A1B0FFFDA355337C" modified="2024-05-29" version="1" fragment="single">LPLGLLNAAQGQAMMVELKNGDALNGHLVLCDTWMNLTLREVVKTSGNGDKFMRLPEVYVKGNNIKYLRVNEATLEIAKEQQQSQGGGYRGGRGGGQSRGDHGGRGVGDRGRGGRGGQGRGAGRGGGAGRGGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U546</accession>
    <name>A0AAE0U546_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_134917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U546"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="58452" checksum="700316079E5B4100" modified="2024-05-29" version="1">MDSSPTRTATTSTVPEPSLPSTTSLKRPAPSLLPPFEPLSSSPGLPRPSKRQATSNAFLKYPTPVPTSSTGILSSSPPRVGPRPSLQRTVSAVSERAPLSDVRSVELNENGETLLMGRSSNSSHYQLSANRLISRVHVRARYIPATEAFEPNKVEIVCNGWNGLKLHCQGQTWELAKGDTFTSETEGAELMIDVQDARVLLQWPRQNKERDASGNLSDSSWDESPRPRVVRSGGNGSASERLQGSPLRRTTRIASPVSPTRGTMSTSNTRLGDLMPDSLDLGATVEIYEDASADEQELPKLTAGNGEASFMTQIAESFSSDLSDLQSDEENDPDEENDPIVHSFGPFGANLNSRLASISTIMSPKPARAPPFQTLSTAPSLAAAALLEPLRPLDTNSAGAITPTAPKSGSTTPTASVVPANPLSEAETAAVSNHVANQLAFSRLSSTPLSTIMNNLPADVKKDMLKEHLRAVIESMVCIGTIPRQGKDAAGKPLESEYYYVPEADTDEHRRLAVTDGLRKPSLRNCRKQHKQYYWKRPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U572</accession>
    <name>A0AAE0U572_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_467670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U572"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3391282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17360" checksum="8C46C13FE2642ADB" modified="2024-05-29" version="1">MASKPIATTNEVRESVVIPAPLSHVWHFIKLQTFDQFWPNITKSEHVKGVSSDTDVVKWTFKDGSVIEVKQDEHSNLDHFITFSIINAEPELSYSSVVNTIRCWPVTAGDCANSTFVQWTSKFSSDADIGVIEDAKYKRRDALKGLGEAVKKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7G3</accession>
    <name>A0AAE0U7G3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_457808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7G3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="206" mass="22843" checksum="F8507E8F0B34A642" modified="2024-05-29" version="1">MNAVESNFMERRCTINTGGVGWLETLHILGRDRRTRTREFFYAESACLPGWNGKAGCMWFFLWQCPGAGRQGGRVGLLTYTHLCTSVTWPPTLPTSPTLFSVRTCVTRKVHGIHHSFGGLPCSRVTIGSKTELTKMCLSFTGWMGVKSEPLFGPKNKVLFALSTCQPSESGRPYANLEQAPAEATAAEVHMEIKKGKRLTNSRPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U824</accession>
    <name>A0AAE0U824_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_30521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U824"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3393909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="530" mass="59736" checksum="BDF2E3DF9F5836F8" modified="2024-05-29" version="1">MTTAPDLPQLQLARSIHCFRATDPPRPPQPRARAKLSQQEKQKVREVRRQGACLRCRVLKIQCSNQNPCQPCLQSAVKGSERKVLSFCYCVRTRFADVNIFQSAWAETPTMQLETVMARMGGLLARIATPANFSLHSDTIVFNETLVSWLTNPQFNLPNGSIVGLCCSNLLSLQFQDETVSGDNLATEFRRFLLATSLVHSGWRGDKDVTQRDLCAAGHISGYRLMKQLDRVLTPQFLAKCGRDSCQVLFLLVLGVVLGVGYSSQNLTDSPSFPTQLLGAEFQKSPTLWLAMKEHLCQMLAHHLIFLGSLLGIKLDTGLERRIIDTAISRWNKMEAFVWADATGLNHQYQHQHQQPQPLPSPPPLRQLSMPSVPIRSGKDAEVVPMKVAEDDQNPPYWEDPPPPPAATAASASHAPLIPIPFPEVAQFRLDHFDQWCENPRSYLDMETEEPKIMYTEPSLPEQRIRIMGPVPRANTEPVLRQDEHAPRKDVRRRSMWVVRSFDAGPEHGHINVHARLRDRREVGSFGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8U2</accession>
    <name>A0AAE0U8U2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_556158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8U2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042199749" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3395062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="312" mass="34456" checksum="8DDDA5E68B0E5410" modified="2024-05-29" version="1">MKSTTLASVLSLGTLAFAAPTANAQRWTKPNDTTPQTWGNSTTSTNLTQTGTTTTSSSPYSVTQTVLPSLQVKWDSKHPDAPGRDSTYGHLLTTPSERVDTAVSFVLTEEQAAGKTCKLVFRLGQNDWAVPSPSGGDAKLSVYRVNANCLNDDYTWNNRPPVGALAGIITPAKGKDGEWEKVDMSADTWEPKMGAAPIWSCSAGDIARLTWKLFDKLKSDQTLSDTKFCRSHFDGEYDDTTGTRPKYKLKVPPLEGSRADWESVSSPEKWESYVEEFLEKRKDDINSRPIAMFSSKKVWLINKSSQIDELEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U966</accession>
    <name>A0AAE0U966_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_386959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U966"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="164" mass="19444" checksum="D87A288F11C34021" modified="2024-05-29" version="1" fragment="single">GPSDPRDMQVMKHFAKTMAIGMKGKLDEEDELPTPHSVRVVMRRFYNAWERHYNLEIPLNQINGPLAQELGLKNLRQDQVFLTIEDYVILQEQLWFRDHYDCVHEGYRIDNANLLNMHCFSSARLQELCQARFKDFVLVGWKDGEPELRLKVRRRECKGKDINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K030</accession>
    <name>A0AAE0K030_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_489466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K030"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="3">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3367593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="626" mass="72454" checksum="3E53DC507E7AE169" modified="2024-05-29" version="1">MSSMDDRFKDVWGTTADYPKTMLRSVRPHEYHERNSRAEKLRNERDDLFDDEEEKLELWETGVENKFSESTFHVVEAMREHLEKDQPEPQIRHAFLESKNSQSPLKCSPEMLKTVFTYHQVEPSFLDAVHTFGDQADPKDLCLMSFRSHDTLTTPKNRLAAIPKLDRSGREIDVSYLLRAPEIKKDNDWPWQIRQAAVYNSFDVITKRSFWCTIKGNDEFNRRIKQSSPYLDIPSDPTDKTRASSYFNASLATHMVYLSWCDENWRQYINDIEDNIQGILKLARKAPIDDDLEDKGSILAAYPKSLRETKTRNSTMRSNKENASKAQSKTNTGLSARPSMRKQSTLEVIAGAQKSLMGYLHLGGAKQKIGDLEKNQGGPAASTMFVENADENSSSEDLVDKRRVLNEFRFSDVQILYTFSDRIRRAILTLTLNISVLQEMHAYYNRLLTVDIESFRHIKEGSKENLAEFLYEIQSLSKRLETRRTQLECLGTLLTEGNALYDGILQYRQLDISQRFQETAQDSAEQMHIMANKTRLETASMHVITVVTMIFLPATFVATFFQSGIFLWNNDVPEDMSETYRYRGDSFNLFVWISVPMMVATVSVWLGVFLWMKKNMLRGVRRPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0J5</accession>
    <name>A0AAE0K0J5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_87070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0J5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="663"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137542" checksum="A4D5682B5AF5B48C" modified="2024-05-29" version="1">MSENKSNSAASDGKKTALSSSVASLQEQVQDYHRRITALEEKLSPNFESAGQRMQRAFSSTQDQDNRTEPTDDGSLDAHEYIFLEHKNTIPEVRECAFAEFKNRFNPSGEDGRYAVDVLVSGLYLHQEIQEEHTLRDRLFEHRGLTPSREIIGKQNRALARAVKMAKKATDAIARSQGDDKWPRRVRIQSPALLRILAKVNGEKWTDRQRTYYRPFNSLVYQHANVKAELAKLEKKLASAQHADEVNMSDHESGSVGSSGGEDDDTIEESPLALECLRAYVEFIDKRVMPDYHRFETMDYTSNAKVRFSDLWYLFRTGEFVYRQVNGERPDRRDFRTGKRIWKTYFLDSVPERLLPTASDDAEIRDAAIKNDEAAFTLACYYVDYTGDEFCVVKDSITIDQFFGEVLVTALPIYPMRFCPDWESHLAFAKETGESLLEFIETKHCSYNGWTLMRDSSGNPTVDQNGNKMTQSEHVNSEIMVDFNEAFQSCPAWRPQRGIMREKTTEGLTILEDFRICWWSGPGRTNLFGETTELIPVKSGVNFKQRNQHLNEDPFVRAIRKNAKGLRPTTKEFLTDDAKILLAGRVFGYVFQERKFAQLAVNKLRKLSQTGLALDALKISPVAKKAIRGAIEGHFIQRDIERKMEKELCMDVTSLDLFQGKGTGLFILLHGVPGVGKTATAEAIAQANGKALFKITVGDLGTTPERLESALRDIFRLASLWDCILLLDEVDTFFSQRTRSEAADKNAMVSVFLRVLDYYDGILFLTTNRAGVLDEAFKSRIHYKILYNDLILEQTLDIWKLNIKRLRKIEDELASAEKRATMEIDEKELLAFARQLFQRAEETGTGPGRWNGRQIRNAFQVARSLAYYERELRAEEIRQRQAEKQSRKRSGPEEDPYKFNPPVLDVRFFKTTHTITASFDDYCTAMRGGTNDAQLALEGETRYDDYQDWFTGYMRRQYIKEHNKNKTGAPAAVAAAATAAAQPFDEQDDGGTGDDNSDDAGPIHPPRKRPRLQVDPGFSSDNNRPPQRKHRGSFKSRPRSGSQLSTGIAASPPSPIDYTTRPQRPAHASRSSGNLELPVAHRAGAARSRNSWEPRSYSPYDEQDDENTDTRGGASRTLRSVSPLDPEDVPRSVRAGNLGGGRQRRLSNSPRPDRFPVGENYEEREWIGSSGGVGGSGGSGRGGYHGSHHYHPYRATTGGKGGGRPVSDIEALEEDHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1P9</accession>
    <name>A0AAE0K1P9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_565734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1P9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="152" mass="17038" checksum="D7FB653F18F9D8AE" modified="2024-05-29" version="1">MSSTMKLETNSKTFKDVNIPFMTVSPWSAPVVHTQGREHPVSRRSPHGLPRFCVPFTWETRAGLRSASYYYFRIGHYGSTMKLGADSKTLKASKRSSHGSPILQLRLLYANASMFRAPDGFKGRVGFTGSGPAMREDPTRSRHVYQPNEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K2A4</accession>
    <name>A0AAE0K2A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K2A4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3368706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="309" mass="31912" checksum="66D69D23D1390373" modified="2024-05-29" version="1">MSDNTNNTGRGPRDSQWANAEPSSSAAPAAQTPLSLGQAQLAQSQLSQSRHAGESGPRGGSRPQGQTRGGSSFQGAPRAPRGHSSARGGASQLGGAPRGNSSTRGGSSRGGGGGGARPQGSPAPPRRNLSDRGGDSSSSTRGRRSTTRGARTQPPSRPNNPNNRGGSSRSQARTPPQGQGPVTEPCCGGTHNTNACTMSNAHRPPADGEVNYFVDIPRCEGGLGDDDPNAPPRPSSRLGFYGPPYPQVEYPDSDSDSGSHYGDSDASEPAQQREAHRVLFPSQYLHRNPDPVSVSVSVCTIPSIFDDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K382</accession>
    <name>A0AAE0K382_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_81466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K382"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3368782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="320" mass="36117" checksum="EC895EE8306BF447" modified="2024-05-29" version="1">MIPKQAPEHPLRAIAPLSIFPEPSIHPDHKEIDREVIDYLVRTWEWPSEKHKRGFVSWKLSDVVLFMFSTGDTYRVKLACELLLLGFLMDDWFDHHTLSQITAVVSRLDTLLASPATFTPRSNIEQMHFSLFTRILAVANTPYEPAILSTYMSMLSCHCDAARDTTTSLRKYLASREADVGMPICVELLYWTDSSLASTTPSERAVLRGLDRVASDHVSILNDVFSFEREWAASADDGAPLVNGVCILANEVGVEVGAAKLLCLALVRAWEVEFRRRAKEVLALAKAEGMDLVRMERAVKGVERRMSGAEAFSWRTRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K3E7</accession>
    <name>A0AAE0K3E7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_565359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K3E7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113944" checksum="559792D426087029" modified="2024-05-29" version="1">MDPKEPDPGSWPQREASDTQVSHVEDCAQLPNTNNRPAMRDYPFATDAKGTAAMQQGSLQQQRELTAAMARISHFQGRKDGFPDDMICRDSVPLSPSSIDGDTSHGRPPHESFAMRVVSQESCSTSSQHREFEELFSRSSISTARPLSPDIDEEAPVSRPTRYSVQSSSKDSGVIMDSEDMPATTNSRPRPHKYDVSYFDTDDESEAEISDAGSIADRCRSDFDYGQSSFYRTPYLNHTHQAPTPSASSQSSHTFDVEQDDSHRLTKILGVGNDSDDVFSWERPDDDQVVQGMFLALMERRGWHNLPDVAKRQMLAYSPEKKWTLIYQDGFAEWKARKKDDMGHRQLLDGHIGKSMDDNHPDTEALSNLQMARLSLNDSPRRVSIPDFDSDDQATITEDVSDAQVDKILNFSLRTVLGVGLADLGSARRELGRSLTLRFAETLAGLVESIAIPEDFDQYPTSSNTRTSSGEDFRGEEPRRPEKSAGKRKRASDPEGNLQQGSGDGCEIATASASATKRQRPTLRIRCPYRARNPHRFNVRDHQGCAMTYFSYMSDLRQHVVKKHVRDDTSTFSCPRCNDIFETKSEQDTHIKRPEGCPSRDLDPEDGVDGETIMRILDRHRQTTKSGGEILVEKQWAELWMLIFHHDDPNDIPSYKYHAVMEDCEFALEWKSLSAFLAAELQLKFGLTGDAPEELRKMLLEHLDLVVETVRAKARDIRYDNRPRPQNANRPGQRRSEVISSVLQNIVGQFSPRDSAIGTETSSNRASDYWQLSFGNNNNNMGHMSMSTPLRPSSQLHHSSSFPEMSRSSISTPPNHQSIVPLTPENLARNEAVVSTAAQDQFLMRPGLHLDVGMSSSQNISTQFSSDEFLPHLASSQQLYQATGPHSAGSYGQSASAMLQTPVSMSGGGHHHHHSMLDESQLSGVGMGILNNNNSNNTYGNGHVRMQSLPHHHHLQQQHPNSAYNNTNNTISYQQQHGVGFGQQFQVNGQQIPPPSVHHQLSDSSFIVDPGVDSSGNPNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4D0</accession>
    <name>A0AAE0K4D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_303673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4D0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3369849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="113" mass="12190" checksum="3EBA8C9A17B67BFE" modified="2024-05-29" version="1">MPLTHKPAAQSGTLPLLFPNTPNAFLGDSVGTTSAAPIAAGFFRMEKGEPLVYEYTYDEAKLIVEGEVTITDETGESVVGRPGDVFLFPKGTTITFEAKDYALAFYVGQRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4Y8</accession>
    <name>A0AAE0K4Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_527955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4Y8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="84" mass="9815" checksum="CD77262C4BEE7C48" modified="2024-05-29" version="1">MCDFEEFIFTCSHSTIRLKSYCHFARNDPNHQCFGVKKLRNVWDQDYECGDCMERNRRNAWAQAQAQRYNGGFGYGSNGYQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5H1</accession>
    <name>A0AAE0K5H1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_305584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5H1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="598" mass="66775" checksum="28B67C177D36F432" modified="2024-05-29" version="1">MAALTRSVKESPRKKRTNTGCLTCRERRVKCNEATPVCFHCVRLSLKCEWGVHIPLKDRKEQKATEARRRRPLPLLSKTSTSTPTPDASSSGPFVLAQIGFGSSPDNGPSMFGSVVGDGVADTSGFLPVASNLFEALAPSFLFYPSPTADMEIATTGLLSSLPSLRPFTNEDHQALDYYQKEIVFGFGSKSPAWSTHAILMKTACKSSAVLHLLLAACLAEMGWLSNDCRPMLDTAGEHYRIGRQLLEGEIADSWADPLVIMASFWFLYLQQRRRSAKTRIVYRELSRLMCDYFSNNHLCRILSSSPPERHQQQSGGNDFICSADRKALLARLAVWLFWADAQSCFQGDGGSMARLLAGQGSSQGILDLYDVSRETLQLHWEGQYPDEELIDDVKNAGALELVHLTWVLVQEINEATETSIPMNPGISREIKSRMDAVRRKYPISSVFRFANSTARVRDRLMANSDWAVANYYALCIYHFRCSLAAEDEDGGAVSMIEGTTETSEALLMLIQKTLETDDRGQTDRMQWPLFWAGVEMTDPFKQNWILAKLKTEGLHEALQMVLLKQLGGRRIGIGIIRQICQEACADIFETGLDMYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K654</accession>
    <name>A0AAE0K654_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_485955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K654"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="130" mass="12348" checksum="1FD191EF76FDFB1A" modified="2024-05-29" version="1">MVSVSNPGVGSGSILREGGRNGVTLGKTLPTLCAVVVSVAVVVVVFFFLKVGPGTIQGGGGGGAIIGTLGKGVSTLYVCVVVEVVFFFLKVGPGTFQGGGAGGVLGGMVGAGVATLAEGPSLSGTEPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8P0</accession>
    <name>A0AAE0K8P0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_527080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8P0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3372228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="361" mass="40103" checksum="B93134FCBF1CA3B3" modified="2024-05-29" version="1">MSASRSSKSGGPYVANNQPRDGRGTSRARSPTPVSEYSCSGGSQNGNAGHDSRGRSRTTKQHSLTPSRSVSRSLTRSPTRSRERSYSRGYDSRSPSRSRSRPQARSRSYEPTPAHKHTKVVVERLSKNVNADHVHEIFEKFGTIVDLDVPLNRSTGYNRGTAYLLFSDEAAAEAAVTHMHEAHLDGNIINVSIVLPRRKISPAPPIASHGANFDPRGPPPNPRRGGAAGGHPSTSRNTYRPRSADRLSRSRSPERSRSRSRSPVVDRSRSRSRSPGVNHRRYRSRSRSPAVGSRRHRSRSRSYSRSSSYTPPPTRGGRGGRGNRRGRGGGRDRRRSPSYDSYDSYDRRSRSRSRTPRRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9H9</accession>
    <name>A0AAE0K9H9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_563603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9H9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF23">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="176" mass="19196" checksum="793431A8830EB999" modified="2024-05-29" version="1">MSNNPTPPILPEGYTLHPGFPSITNYCHLRAASGLTPKTEAQAAPIPKGSWYGCFITFSPPAVIITEASTPEAEKTVTVAMGRIIGDGGWYYHIVDMAVLPEHQRKGLGDAVLKHLLAYIQANSAEGLPYVNLFADPPGRKLYERNGFVDALPGQLGMKLPRTWVVKREAVEEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KD85</accession>
    <name>A0AAE0KD85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_253142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KD85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="19527" checksum="76707F81526DF053" modified="2024-05-29" version="1">MGLTVDSDRLPVISAIAAQLHKSQPDDTHYLAGFWSGNFFEQSLLWMALELPPECPGRPNSLPPPTWSWASVKVPIQIPWPYEYTPLFEVLSASCEYVDPNNPFGAVVRGRLVIRGRLLTARFGYSTGGLLQGPATIERAWHGEKFLSLREDVDLGPRRDESDPLPFEPRRPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDH5</accession>
    <name>A0AAE0KDH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_562741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDH5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="123" mass="13740" checksum="69B6E8CB24BB7BC4" modified="2024-05-29" version="1">MAMLRIWAVDASCPGANASNAQPAGLLVLQRICRPSKIITTMILRQHPQPTRLSLGIPRTVEQPDHASACLFPPPNIRQPLDDASPQARRCRQDPPYRGPPEGRYSAICDTFTHMGWRRSCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KE85</accession>
    <name>A0AAE0KE85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_481874</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KE85"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="280"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3375108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="722" mass="81789" checksum="496A545D676D0F6F" modified="2024-05-29" version="1">MPIATSPSVLHPATFAKMEDRKRPATGAVDDCAPPSKRQAVNGSGKSKDDSGDMKEEAWIEDFQKGAIYRQMLEYKREKATLENRLQELEKKSVYHDDHIRIADAWLLQLVEEIELAVEGTVSSRGSLDTTPISALSFKDSKDFQRHLGDKSKTIKSKTDSLFKRLSSARGDIKPETAQLEAQVKSLLANQKDLAVKIERLETENASLSEQYDTATLKAIKAERKLDRVRSLQVQKLEQQALANATTRPSSHDDNGSGTTMTNGDSDELKLQYQEAVAVVAKQKEQIQSALSELKSLQEENATFKAKRDVITDEDYARTEVFKQFKGQNEDLIKRINHLQATNKQLLEEAEKCKAERTAVQVQLKHEADSLTLDLEDQIQQKDQDLTRIRSARDELLAELQMRRASQEQEKTASSHLHELIEAKQDRIEQLESELERLRPSEDVAISDSRPDLEALSLDELRSKYTKLEKDFQEINKELPLLERSYKKSQGLAHKKVMDFSALEERIAVLTAEKGKADQKYFAARKDMDIRAAEIRTLRAQNGKSSEIISQLKDVETQNRALISSLEKQIADLKQSNSSILAENKKLESISAEVTRRADSVKAQISDLTSLVKSKDAANASLKEQLMNHETELEKVKVRLREATKDCDKWRHKCQSNSTEEEEMLRNLVLCVCKSNFKNTILKGCGHVFCNVCVESRLTNRMRKCPTCNKAFDRSDAMSVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF66</accession>
    <name>A0AAE0KF66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_278301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF66"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="935"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="843"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3375394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1196" mass="130681" checksum="20F1B05B52453280" modified="2024-05-29" version="1">MLGIYGANLENGDETRHNGEDRGRTALSPSLQIPKNKSTSNLTVIGDSSEKARVRFSFDAGAAAAEYDTITRSSLVTDHDHGLGLSGLRRIRQQHNPMRAPTLPSPSSRTPSLSALTRSSSLTTMIEPPLSPGPGSPTFVEDLSRFPSESLHSFSFAHQSEDLIHNRQNVLKRSIEFMKDRMGWSAGSNAGIASAQARVTGDVDMQNMLDLLAKAQLVGAGNIPNGDPLIALSTGPLSGPAMVSGENVFDKQFAPRSASPEAIEDTPLMSPTAKRSVEAGLAGDVSAARLKARPQVSPSSQGAESENSSRTPTNESGTTAKTSPPPSRRPSTLKRTLTDTFHASMQQKLLDAMATPYHVGEPQMGSPTITSQSFSSAITQQSAVSSSLHHSTRWVPAAQAIFTTEAKAPWTILAANDLACLLFGVTKAEVRKMGILEVVQEERRAWLERKLRKGSHEDTGDGSESEISQPTPVVPTSSLLGGRGGGITAKLLSKPNSRSQTPKNGGRRPATIHSGDPKPPKPGHSHHNADKSRGVLLCGDVVPIQKRNGATGAASLWVKEKRVGLIWVLEEIHEDVANVVLGDEGSVVKMTGALGPIWGDDSLVPGMDIGTLIPRIPRQGIDPRYGEIDYMEVAKRKYFTCRNCDRINIPATVEQVRGAAELRVSSFPHIAGIIVVCTKTLSIKSSNSVFCGALFGHERPNGMSINNLVPDFDKVLRILTEEDGIRLVDGIVIPEHSFRKAAAFLALREGRPDAANGFLRPEGLPARHRDGSELKIDIQMRVVKSEKQPMVLDEAVIETSDDESASDGSEAKFTAPQSEMVYALWITYSRHLHATRTNLGASSPLLSGTATPLHQPSPGQTPAHTPLEMQSDSEEPQKERSAASMLARQLRDAALLAAAKLTGSPKAPAAPEAPEDQVSTTKPDESSHKKTIDDFVILEEMGQGAYGQVKLVRYRNTGKKCVLKYVTKRRILVDTWTRDRRLGTVPLEIHVLDYLRRDGFRHPNIVEMEDFFEDSTNYYIEMVPHGLPGMDLFDYIELRTNMDEQESRSIFVQVARAIHHLHTKALVVHRDIKDENVILDGEGRIKLIDFGSAAYIKSGPFDVFVGTIDYAAPEVLAGKPYGGKEQDVWALGILLYTIIYKENPFYSIDEIMDRDLRVPYTISDDSIDLIRHMLERNVTQRYDIEQVLAHPWCDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJL2</accession>
    <name>A0AAE0KJL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_398732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJL2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="304" mass="32834" checksum="8ED32E6DDB644818" modified="2024-05-29" version="1">MATSSPLLKKSVKIACVQLASGADKPANLTHAADKVREAASNGAQIVVLPECFNSPYGCDFFPSYAEPLLPSPPSPEQSPSFHALAAMARDNGVYLVGGSIPELVAPDFSSSPPFKPKYCNTSLTFSPAGTLLATHRKIHLFDIDIPGKIKFKESDVLSAGNDLTIVDLAEYGKIAVAICYDIRFPELAMIAARRGCFALVYPGAFNTTTGPLHWRLQGQARAMDNQIYVALCSPARDVKAGYHAYGHSLVVDPMAQVMVEAKEDEAIVYADLNSAKIEEARSGIPLQDQRRFDVYVDVSKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJY1</accession>
    <name>A0AAE0KJY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin-like [2Fe-2S] ferredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_227306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJY1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3377838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="261" mass="28798" checksum="8B0E7514EBCEE28E" modified="2024-05-29" version="1">MASKFTPLFLRTAVRSACRVSRPQQTRAFSLSAQRPSDTLMVHRNTPDNNPSIPFKFTEQNEAIITEILKRYPPQYKKAAVMPILDLGQRQHGFTSISVMNEVARILEMPPMRVYEVASFYTMYNRTPVGKFHVQACTTTPCQLGGCGSDVIVKAIKEQLGINQGETTPDGLFTFLEVECLGACVNAPMVQINDDYYEDLTPETIKSLLSALKESVTDVGKSAKKVPAPGPLSGRDTCENSAGLTNLTSEPWGTETTRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKD2</accession>
    <name>A0AAE0KKD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_219439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKD2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3377480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34777" checksum="2EE09AFBA6DDD0D0" modified="2024-05-29" version="1">MDTILKLVGAATLAVLSYKFIDAASLWLLPPISLSRYQQRSSAGKPTSWALITGASAGIGLGCAVELALRGFSVILLGHKPSELEEAKASILAEASVEVKLLVLDATRASASEIDAALDSISHLPLGVLVNNLGGMVVDPKKGWLHAVDEFSGQELDDSLALSARFMMQASRKLIPSLKQHALEGTRTRSLIINISSFAHVGMPLLATYSGCKGFINAFTTSMARDFISKGVNVDAIVIVPGDVRSQSNTTAPPSAPDGRQFAKAIMNKVSRAVDKGWIELAPIWSQAAGVWVIKAVLPETLGRRALYGAISEKRDIFLRSLTKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLF4</accession>
    <name>A0AAE0KLF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">B0H63DRAFT_236287</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLF4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000295">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5041757319" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041757318" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="556"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3378095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1171" mass="128949" checksum="2A261D6F32E818A0" modified="2024-05-29" version="1">MVRIIPNRLKPGYSSHSTSNSTANSRSASPMRSKGDSASPEGRKETGLVLNVVILKARDLAAKDRGGTSDPYLVLTLGDSRHITHSVPKTLNPEWNEQCQLPVNGVQSLLFDVCAWDKDRFGKDYLGEFDLALEEIFSADDKTEQPPMWFPLKSKRPGKKDGVVSGEVLLQFSLFDASNKEATPKQIYEKFAAIAKSVPVTESSSRNPTPTRTPILTPTTGRGKAQSLSPPLSGRQGDNDDDDEYEMYEDETPEDEDPSKPEAIEKRKRRLRIKGLKRKKRENPYEFINGGSDVVGIIFLEICNITDLPPESNLTKTSFDMDPFVVASLGKKTYRTKMIRHNLNPVFNEKMIFQLLGHEQQYSFAFTVIDHDKYSGNDFIASVNLAVKDIVDKSPKADPETGLYNLKDVPEYTPVQRPRFMRLGMSRTASSQSLSKLARPPLSKNPSTITTASAAVSTATSTPAVTPGVAPSSKAPFDGTGESAQQALAAPGLLQPGGDAVAAAANSLGETTPPDGDDPDFVPVTLPLKMKNLEKWEDKHNPQLYIRVKYMPYPALRQQFWRAMLKQYDTDESGRISKVELTTMLDTLGSTLRESTIDSFFQRFPHKAGDSDDSQDLTIDEAVICLEDQLEAKTRPAQSMTDRVKNFLPDADKVKNLLSVPGVTSSSGTESHVVDGSATPTESQLADASTISIPELATPGEEGELLDKDDLNIGSSEEHVVEIRECPICHQPRLNKRSDADIITHIATCASQDWRQVNNLMMGGFVTSSQAQRKWYSKVITKISYGGYKLGANSANILVQDRMTGQINEEKMSVYVRLGIRLLYKGLKSNSMEKKRIRKLLKSLSVKQGKKFEDPASKAEIPKFIEFHGLDLSEVAKPLSEFKNFNEFFYRALKPDARPCSAPNNPKIVVSPADCRSVVFNRIDIATKVWIKGREFSVKRLLGDAYPEDVSRYGNGGALGIFRLAPQDYHRFHIPVDGIMGKPKTIAGEYYTVNPMAIRSALDVYGENVRVLVPIDSSEFGRVMVICIGAMMVGSTEITRKEGEEVKRAEELGYFKFGGSTLVVLFEPGKMVFDDDLVDNSNGALETLIRVGMSVGHSPTENAWKPDMPKNEDQITEADKKEAKRRIQGSVMSEGGLESPDDSDEISPAAAKANAKVIPPGDTATAATAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1W2</accession>
    <name>A0AAE0N1W2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_456110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12457" checksum="1CABA7F746D31EA4" modified="2024-05-29" version="1">MTIPVAVPLRSRLPIWKPSWPTLSQAALGRFQKTTKLEASEKHQKGLHWGVEVLRASRDPKGVWYLVRWKGGEWKDDWVLEKNIHRELIQKLRPRQKAKRKKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1Y6</accession>
    <name>A0AAE0N1Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_455822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1Y6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="260"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="638" mass="71451" checksum="CECAC4253861093C" modified="2024-05-29" version="1">MQSLSPILQLRWGAAGLIGLLQGKGKSSPPTPMLPGIEFTPNDCQHHTILNLHVVDNIIRNLASTTRLYATVNPLSAASSIAGLVSIAESLFRLVFKYVKSVQAAKNEIVELADEMKTIAGILHSLSLLPRRTMSRIKQPLVKAERDIESSSRFDAFQRRLKWPSSSSETKDLLAELSRHKETISLALAADSVSAIAKCLSRQDEIVRRMSNIQGLIDQNLDITTRIALDSNHSKVLDSFLTVNPQHNLEMSLKLRHPLTGLRLTEGETFQQWLESSPSENASRLWLSGIPGIGKTFLAGAMIESVMRSSHDTATILGALASQIARQNDEAFALLQEYYDQLHPTDKLPRSPDIKELVSLLKLMSCEFFKTFIIVDALDEYGDKLQMANVVHTLKSLVLPVGHMQKDDTPLTGMINLTLVSRDKDPIRNQLENNFMQMKVEAHAEDLQIYTAAEVDNRIRNQLLRINKPGHKDEIIDYLVSPCRWNIRMFRWVSCQIDELCKFPTDKARIKAPRELPPSLNDTYERILKRLCEAISISDDGLMDSKAPVVLDPEETVDEREIAFSCGSLIRKSSTGEHFEFAHFTVKEFLETLDTTKPHLALFPGPWSLAATMLIRDGQCIATSCSVKLLLVSQILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N3E0</accession>
    <name>A0AAE0N3E0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_455437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N3E0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="68"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3368683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="469" mass="50994" checksum="81BD554654AD25AE" modified="2024-05-29" version="1">MSWQASSPRGDLPWTQIGGPSFNKPKVKVDGSGGGGGGSNHQEVDTVSHKIFVSLWVMVGISLIIFALRFYTRKVLIKKIGWDDFAFCASFALMIVYVGLLTVGYKDPANGGTGGGEAEPLGAHIARMAARAKFGIAAQGVVTLALTLAKMSFGLTMLRIVTAATSRARYVIWFATTIILFSGATTSLLAYVECLPPFLKKDVMFESFRGCSTAVTWMYGFGGVCTLAALAFATIPWVVIGQNANLQMKEKYVISVGMLITAAASLTGVYRTVALKDAMAQMSSSNHQELVIKVDEYTMDAMRVNAWCTADITFTLICATIPILRPLWRQWFPCWNDKLLISDNNETNGSGPASDRRATRLSENLPFGMRLFESSVSANISDDRLHGNRTPGSPMSDSPGMRDDYGRVGNDTTENYRLVTSISRTDFNEPEIQVPNAIHVRTDLEIRVETVIGPTVAGPTVMGATSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N449</accession>
    <name>A0AAE0N449_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_486124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N449"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="302"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3370092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="58354" checksum="CDF08A187169B239" modified="2024-05-29" version="1">MIRQDFNRIEPKRRNVLDHRKRQFADPTYKEAQYPHRLNLYATPPTADITLEQFEQWAIDRLRILAELEACSFRNKSLQDTAAHMKPLLDKYLPLDANSASSTQRITQRQKDHYSHFILRLAFSSTEDLRRRFTRVETMLFRIRLGADDMRERAEFVKGLNLDWDPVTEDELRRYATELAATAAFGSGKKAQQARDEESWCKVDWMRVPELVESRRVFVKAGQAFVPFREQQSMVVTEFTSRLERALELTARALPRLDEDDRLTPILNHLSKNFVAPDAGYSGGDSAVDGAEITAANIDKLSQHFPMCMANLHRTLKRDAHLKHYGRFQYTLFLKGIGLNLEECLVFWRQSFSKITEDKFNKDYKYNVRHVYGDVGGDANRRGTGYSPLSCQKILTEHAPGTGEAHGCPYRHFSAENLSALLQATGVSDRSVLQGVIEDKANTKYHMACNRVFEHIHKNEIKRARDDGVMSAAQLETIVHPNEYFKRSYLLKNMGKQQAGGGDVKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4K1</accession>
    <name>A0AAE0N4K1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_421632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4K1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000165">
        <property type="entry name" value="Serine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041904948" evidence="6">
        <location>
            <begin position="26"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3369928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="562" mass="61791" checksum="5757F24BE9605CDF" modified="2024-05-29" version="1">MGGSILTSLLLSIVLGLLQAQLAQSLFPDALLRPPPVKVTLSGPHGGNATFQQLINHTNPSLGTFSQLYYWNTTYWKGPGSPVVFFTPGESAAAGYSLFLTTESLTGLYAEALGAAIIIFEHRYYGKSSPFEVLDTRNLQYLTLANAIADSVHFAKAVKLPFDKSGKSNAPSAPWIFVGGSYPGALAAWTEKVSPGTFWAYHASSAPVQAIYDFWSYYLPVQEGMPRNCSSDFSKISMHVDDIIESKNYKQIASLKKSFGLHALKHDDDFASAVASPVNMWQGIQLVGNDSTFFQMCDTIEGVHPVDLNGTGNGNSTIAATVVGPSGVGTVKALANYASWFKHEWLPMFCYWSSGAKYDATYKDYKDPMSVGCLDSYNTSSPVFSDLRVNNTANRQWMWLLCNEPFFWWAAAALEEDGILSLLPRAVSTDYQQRLCGVFFPKEGNATFGSHGGKTAHDVNRLTDGWNLTNTTRVLWVNGEFDPWRSASVSSELRPGGPLKSTKKAPVILIKGARHCNDMFTVTGKVNADVGRAQNLSIWQMKTWVEDFYLPAEQRRAKEWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4K7</accession>
    <name>A0AAE0N4K7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_564687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4K7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13418" checksum="A35275AFCB42045F" modified="2024-05-29" version="1">MAARMGDINFINFLLLQPGVDINATTRDGSAPLSFACFPPRHYASYRNIEKETHQRAFSTVRMLAKRRGRLGHDNIVHNLVNEYPCAIPYVVRLIDLGVDLSLPTDPEDKEALLAARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N4Q6</accession>
    <name>A0AAE0N4Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_319638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N4Q6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042163478" evidence="1">
        <location>
            <begin position="21"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="497" mass="51561" checksum="2D08BD63FDA41454" modified="2024-05-29" version="1">MRWPWAPTALAALLPALVSSVQITDTLRDADPAQSGYLPCHNVDPSKVSQYTRIWQSIAQANEFYLAKPLVYTPAGSSNELVIVASNFNIIRVIDGATGVVQNNRTVMAPFAAYDADCGDIQTSIGITGTPVIDPATDIMYFFAKGYKDGKGPGDPNNPGSTVLNGVYKMYAVRVPSLVDVPGFPVVIDGNFASNDPTRYFTGGTLLQRPSLAVIGNNIVAGFGAHCDNFNYTGMIVSVSKTAGVGVTGVQAMVASPGAPSPIPLDPKDGNGGRAGIWMSGSGLAHDGGNRVFFSTGNGRGPGVNSGTIPMSGKTYLSTLEQAAVAFSVDSGSGALTQSDWFETANFDMFNGGDRDIGSSAVALLDPTVFNGAGVNRIAVMGSKAGNVYVMDADNLGGFRMGAGGTDAIIQSWSIAGSFFGGITSYPLEGGYLYLVATSGPIIAYSFSRDANGRPVFTQAGKTAQTFEAHNTPAVTSLHGTPGTGVVCQPLEDPDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5G7</accession>
    <name>A0AAE0N5G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_309189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5G7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042243718" evidence="1">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="262" mass="27242" checksum="65064DE975312760" modified="2024-05-29" version="1">MRTSTLLLSALGATVFAAPTLPVLNPDAALPGSIDTVSEYFNMLASKVQASKLMSLAPVCDLSKAQLPVLTGATTLPPPTAGFVLKHVALGRGTQNYTCDVNNATAVPAANGAIATLFNASCIAATYPDLAKQLSKVALQFNLTGDETKMSPSNLAVTGSHWFPNLTTPFFNLDVSRDLKLGQAACAKNNSAPAPADAAKGQQGEPAVPWLKLVTKAGTTGDLQEVYRVETAGGSAPATCKGMPASFTVQYAAEYWFYAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N6B3</accession>
    <name>A0AAE0N6B3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_294900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N6B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="1">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="514" mass="57546" checksum="3ED36FBC358614CB" modified="2024-05-29" version="1">MATEADFDLNQLEPSQQETLQQFMEVTGQEMQDAVPLLQRSRWDIQTAISRFFGDEERDPEIQRLLAEADAAQGYMPRPEARLENLQESLYAADSVPLRAARPTTDPAPRVVPPPPVTYRLPFLLTVIFAPFRLGYALLRGVWGILSYPLSFLPQSLWPFAVNSSIRMGLRGTSSARRVVLPKETAERFRREFEEEYGAHGLTFFEGGHAQALDAAKRDLNFLLIVLISPEHDDTSSFVRDTLLAPEVVAFISNPAHNIILWGGNVLDPEAYQVATEYMCNKYPFSCLACLTPKEGSSRMGIVKRLIGPMEPDTYIAGLHSAISKYSPDLDGVRAERAAQAVARNLRSEQDSAYERSLALDQERSRKKREAAAAAAAAEKKALEAAQAAARQEELRQQWRKWRAAKVPAQPAAGVRIALHMPLSAGGHRVMRFFAAESTLEDIYAFVECYDLLQEDVVDEKKDKPESYEHKYRFQISNFVPREKLEPSTTTTLGEAIGRGGNLIAEDLDDEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N777</accession>
    <name>A0AAE0N777_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_453388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N777"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="785" mass="87036" checksum="0AFE5E7EE658CE63" modified="2024-05-29" version="1">MAPYLEPLNTNAATAGNRDLNLLSPSDYDGDAVSIRSDQDSDSDDDERQLRARNSRELRAHDRLVLMEEEELDQLVTETRRRQQRRGSNLPIPNPLRLFARRMSDVSISRSRSPTGQTPVEFAVETPISEKRSLRRARRKAKRDRLLADAQEGEDGELMYEMEEGGIKSGSSTGESSDRGDSDEVDRKGLLQLADAKAKRSRNWCRWLLIYALIAVAFAILVLLAWKLSMERKRGPVRTLISNGTAMFAPTTILISLDGFRADFLNRGLTPRLSAFVKEGVSPLYMLPSFPSVTFPNHYTLATGLYPESHGVVGNTFWDPALREEFYYTDPLRSLDPKWWKGEPFWITAQQQGLKTAIHMWPGSEAHVLGIEPTYMDKYKGNEKLSKKVSRVLEFLDMPDSERPQIIAAYVPNVDSDGHEYGPNSTEIRSTIQMVDSMLDKIFQGLEDRHLTNIVNVIVVSDHGMATTDINRLIQLEDLVDMNKIEHTDGWPLVGLRPKNPDDLQGIYNGLVEKTKTNPSIDVYLRDVNMPERYHFSNNERIAPLWIVPKTGWALVKMQEMNIKEAKAQGLVYHPRGLHGYDHEHPLMRAIFVARGPAFPHQPNSQVEVFQNTEVYNLLCDSVGIAPFPNNGTLRLPLKPIGLHSDPGTELESPADPVTTSSAAAASDSPIVSSSAIGSVAAPEVTKSAADDHAVQISSSSSYTATAPSGAPAPSNSIGVNLPEPPQPTEQPSGDQDGGDTVETGVKNFWDWFTGKIDKWWGKIKGGISGEKGEENPGSSSGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8Q2</accession>
    <name>A0AAE0N8Q2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_262062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8Q2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="247" mass="27500" checksum="6669F256363A7917" modified="2024-05-29" version="1">MHAPTFAQFLVGVIVTSSAVAFQVTTLARVGSALAIAAPASALALPSFFGTGAPEIEARHHKGKKTKNARDELEARHHKGKKTKNARDVEEDDDDDHDHTDVEARDIEARHHKGKKTKAVNARDTSEIEARHHKGKKTKNARDVEEEGDDDEDDDEPDVEARDIEARHHKGKKTKNARDLSELGARHHKGKKTKNARDVDEEDDDHSDIEERDVLEARHHKGKKTKNARDVLDARHHKGKKTKAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N991</accession>
    <name>A0AAE0N991_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">MIDAS-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_549328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="4756"/>
            <end position="4959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4100"/>
            <end position="4669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2949"/>
            <end position="2976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4102"/>
            <end position="4112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4124"/>
            <end position="4140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4148"/>
            <end position="4161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4178"/>
            <end position="4208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4237"/>
            <end position="4260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4261"/>
            <end position="4291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4314"/>
            <end position="4344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4372"/>
            <end position="4412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4493"/>
            <end position="4514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4521"/>
            <end position="4550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4591"/>
            <end position="4613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4615"/>
            <end position="4625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4632"/>
            <end position="4658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3374940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="4969" mass="552697" checksum="8D10B9B85CC037D5" modified="2024-05-29" version="1" fragment="single">[encoded data, 4969 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NB46</accession>
    <name>A0AAE0NB46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_502250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NB46"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042214243" evidence="2">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="401" mass="42460" checksum="892061061FAF6B6B" modified="2024-05-29" version="1">MGPFQTFVTALAAGSVLFGVAIAHPGEEHSVGHIKKSLAARDLAVAHAKEASKCAGSASHAALRERAVARRALTAQLLREKRNVVDKTMVHRRDQASADKWLNTCHDQSGQYNFDLSTAEATIFASKNATSALTPETIIGPYFVAGEYIRRNVTEGQAGIPIHLDIQFVDVTTCEPVPKMLVDIWHCNATGVYSGVSAEGQGGLNSTFLRGVQVTDADGVTQFDSIFPGHYTGRTNHIHVASRLGGAILPNGTYVGGSVNHVGQLYFDQELISAVETMHPYTSNQVALQLNKADFLVGDEATTEYDPFIEYILLSDDANDGLLMWITIGVNTTANYDSTALPAATYHEGGGKAEGNGAGGPPPSGGGFPGFPMPTPTPAAGPKPWGPCLSPKKGKKGTKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCC3</accession>
    <name>A0AAE0NCC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_495431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCC3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3377429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="307" mass="33840" checksum="11AFD8A11405C3C2" modified="2024-05-29" version="1">MGPQITPLRVGYVPEHFSTPIFFAKKHYGLDAKLIPFPSGTGHMITALRAGEIDIGIGLTEGWIAGLGKDTADIGDGGYKIVGTYVETPLCWAISTGAKRPEITSVDSLKGGKIGVSRIGSGSYVMGYVLADQRGWLVPTTEVGTASESASPFSEFVVLNTFENLRKAVNAGDADFFMWEHFTSKRYYDSGEIRRVGEIYTPWSSWKIVASTKLDSQDARVEDLLEKLNLGIKHFNENKEEAIKYISTELDYSEEDAREWLKTVRFPELTQGVDPKVVKDTVEILCKAGVLVKGKGMQPDAMITKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG44</accession>
    <name>A0AAE0NG44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_523595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG44"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF15">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64172" checksum="4D65C2216729BBA4" modified="2024-05-29" version="1">MTSPAQEPSVQQLPTKGLCEVCATAFGSCIIDTWADDPPTPELAPWGAWTHRFVLHHSLAAFCDAVDKKCFICCSAILALERHHQDLLTTIAESEHLTTSGNDGCAVSDFLVCPDSHAPDDLRMFPFLYIIVSSNLRYFDELGLIKLDEKPEPPSSTFEWVTSNITSNSTASDEAYDHMAKWLRDCESQHEHCQNRASDDIWHPTRLLDIGITSKVDIKMVTKIKSQPRADMSPSATAGTALSQPSPLTHWQAGLKKSLLNLSERFPEQTPYLGRCRNTRFKDFPNDSLQLLASSAAHGIEKASEKNSNTNHQACTVLPSPTATACYHTWVVIIHTYVRCQLTFASDKLVAITSVARYLKGFCDNDLYIMGLWNFNIAGQNTASDLPPAFHIPGQNDSVLYRALSFSWASVNAVCTFPKVNQPGILVTATCIQYRSSGADQDLPIEEDIIDSLPTGPTVELKVVGRLIRAKLLHVGEQSLIIWPQDLLPGTTNNGLTADKKNPPPPTDNSGVWKAAELDFDIGPDPDVVPSIAKRQFYYMPWQEDFRDNPRQDLHGFQCLVLELVDQSMGRFRRVGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGB2</accession>
    <name>A0AAE0NGB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_474763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGB2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31775" checksum="CAA65D4B3D2AC6E9" modified="2024-05-29" version="1">MTSSPSSSNNNNPIVFYDIAQRPPVEKTCCAPNPWKSRLALNFKNIPYKTTWVPLPDVAKVRSSLNVPACRKFADGTDFYTLPIIHDPATGALVGDSFDIAVYLQKTYPNASAGDDLLPPQPALDDYRYAPDPVLLIPLSDCSAAGEFSEYARFNSNVDMAFTMHVQLTLEGFPWDPATAEISKAEFVRRAGVSCYEDLALVGEAREKTKESFRNMLGGLSRVFLKDTSGPFVLGKKACYADLIVGAWLRMMYVTLPESEWEEVRGWHEGIFGELHDALEVYAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGR3</accession>
    <name>A0AAE0NGR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_475184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1374"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1579"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3381256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1590" mass="176930" checksum="93026A377B57DBBA" modified="2024-05-29" version="1">MSDSIAPMGDGSGSTPRFSTTDAGVEPSVVPKIEVTPSTRAKVEEVTDVRKPTDRGKPTESPKPAPTVPQGHAGGSVAQDTPRQHSEPEELGVLSQLRAATRRKSRGHGGSQEPTEEKGKKKATETPQPSEETKAALTEPPYKECHSVAPPKDPEPGYSMEILHFPKAMQSHYLDIVVVHDHDETTDSWAYRDAEQVLRKEIDNIKMKVKPKPADPKASNHLSVAETGLGATELESSRASSPARFATGSNWLSDAGMLPKMLPGARVLAFSYPKLRPKEGGQAGYFKRAAAELLSELAKARRSENAHIVVPVVFIGAGFGGLVIQIAIALAAPAAAERAKSTTKENTAEPDKGVSLGLDQVADVIFLDTPFPDGSGHERLKRFFPANSNLRMCAIVQVMEKMEAQWKGLTVEKIWNEFWESLGRLAPETRVTWFYQSQRPANVASVRLPSAALGPISQTITLNPIIQQRLRRLTNFPNSSDKAYTRIVTCLRNHLMFKAAIDSRLKQLQSDLMKGSDIPVNLNTTDERGRTPLHLATMAVNPAGVNLLLGNHADTQARDPSGQTPLHHAIRIFCEGADLEAARQDQVKDVISQLLDYTRKTELHTNRDKSGLSPKDLIHDSREPCSSFPAPCRHAAIRELLESHQPIVRRRSEEQVEDPWRGWGPPHNELARRACTQARAILAEFYESTAGDATETGQLLADLDAPNILDLIYRKEQGPVRILSKLTERHVISKGDVCCRWIHVPANNEQWIHDLFIRLRLRDGSMTGQRHSAHAVYNRYMATQVRRYRQGKFPPAIEVEASPTAPSLAMTAVSEHPPTTDAKAADSTGFLEILKAEGGGWPSVSIPKELSGASEAVVLFMPVLAFENHRGRKVMSRAINRILKPQNTPDVPPLGSPDSATAPDAAGSKKSAKNMNIDTSLIEAYLQSEKPLHCRRTLDQYSYYMLESTESRDMDQVVYKWARNQQDKQKQASIKSAGADLFLNEYGGSEEGSRGIPGVLEANIEVVGADKDRSHKVLRRPKHRPIIMVDQLWLWVLPDGTVITSLPNTADAGEPYNLKRWLEEALFEDSIEAPTQSVDDLVGTIINICVDFFQREGPCGVKFQHCFQYSISAIAEDEVDMYTTYKNMVEFLENLGSAASSSSKLIDGFSQITRETNRLVEIMDIQDELGIVDSILATQKDVLQKLMQHIPKKGRGERKAKPQKTEGPTPAKETTVTQTAALRDSSRIQEAIHIVEDNIRAVAEMIGSAKRVQEDLKQLLDFKQQQSSAWETRFSRKLAEQGQKQNNIMLVFTLVTIVFLPMSFITSFLALGIRDFPKDDNGNTAWPLDRVSGYLFGISIAVSLPLIITAFYVNPISRMVTGKRKQDLRHLKKFSQAEGGDSDSSDSSDDDDSSKNTIKAKKKRRGADDATDASSLTIVDDNDDDDSNYAPLFGKPELTWHTKIPYVRRLWEWKTYRLHELEDLNAGLENLDWDYPLSHWRKKVADPVRLMMVRLGLHRLSEAYGRHEETYQQNRQSDELVRNYLGAKRELRGQEIMAERKQRRARGEARALDATDPQPPMPGLGPKLASSVRGSLMRRGTERRVPDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH66</accession>
    <name>A0AAE0NH66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_203996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH66"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="327" mass="37230" checksum="0770155413D52E85" modified="2024-05-29" version="1">MTDVSETRLYLGNLPRSATKADVEAHFATHGTGEITEIKLMNGFGFIEYKDAMDARDVVPAFHGSDFMGERLTVQFARGARRHEAGATLSGHERSAAPRPRRTAHRMQITGLPNDTSWQDLKDFARQSGLDVVYSETGRNSNGEGFVEFETASDLRTAVEKLDNREFKGHRVTCVSNTQADVPRGSVNGGGRNGRSRSPRPPRYPGPGDDYDRDRRVRAYSPRRESRDYRADYRDRPSPPPRRGEYYDDRRPYRSPPRRAPIDDYPPPPRRYADDPYRGAPARDYPPEPYMNGRGGGYDRPRPPPEFPPRDGYPRDGGFREFDRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHC3</accession>
    <name>A0AAE0NHC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_206181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHC3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042038190" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11731" checksum="ACB02A10B7103055" modified="2024-05-29" version="1">MAYLPVFLLSLLACSSSVKAWSRPGCTTPSLRALCNQEAVTRLFSGDRWKQMVKEIHRIYIAGPFCRFLSQLRVNQCSPDSSPDSQLSPVLVTVFLFFRIHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHQ6</accession>
    <name>A0AAE0NHQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_211416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHQ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="251" mass="24265" checksum="CDE2F781376CAF62" modified="2024-05-29" version="1">MRDEGGGQGGPVIRAGAASEHACTVCGGGVPLSQPAIYLSLAANERTTFSVPSSSLFPLISICDSASSLSHQEQSAAIDFRPSYRYNLVNQKLLPNTANMPGIPFGALDNLKAKLKAALKKKTKTTESKPAETPAATPATAAAPAAAGAAVAAPEAAKTETAPAAEPAAAPASAKPTPVAPAKDEAPAAAPAAAPAAETPAAAPAATAEIPAPAKAVEAPAAAEPTPAPPVAEAAPAAPAAAASPPATTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHX8</accession>
    <name>A0AAE0NHX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_511499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHX8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="526" mass="56471" checksum="DFE5A1A13464A6FA" modified="2024-05-29" version="1">MDAGTLGAFPVEASLITLLLAITSAVANILIHVLSQGAAVTWWFLSMDQRESQVQDLHCRWAAADGFVDAMKSIMIRGPSKTAISCSLATIAAINSPLLQRALMVATDADLSTVPIDSIYAARRLPSGFTVQITGTTSILTILTADFGAVMREYVSKTLILNSSSLPNENYTTQLEAAGYSFSCTESAIIFRVLNNTDIFVNSITYSEVDSKPTISTVLSPRFQSLSNFWEDDRRLNIFKLGRLFAYDAVWKEQAGCINDTHGAVLRSRRCSIEPATVRYPVVIVDGTLALDSPYSYLDAEEEILSDTASGSSSTHGGMALVHDARFAASYIIKSDEQMLDIGGLWDKVTVGLFAHEMVTTTGEDTVGGDAQCQSWTFHDPGPFVFGALRELALRSALRAGNASNPAHRQDVEALYKTTVAVYVANVGYVVGAMVVTLLAALSVIPLFHGFSQLGRKVSMSPVEIAKVFEPVQLQGAPSNATARVLLKRVGKRPIKYGVLDGGDSLGMGDPSETATPAKQSESGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNR2</accession>
    <name>A0AAE0NNR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex non catalytic subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NNR2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112836" checksum="6B1245B263663703" modified="2024-05-29" version="1">MSSYARYGRPTLKNSVDLQLQNAFSDGNWSTVIRLADKRAKTLKDPYYEAIKISAESQLDGAADKCAVLVALDDLVRQKAVPDADTLELYEWAAQDFLRIDLQYAEAIGPLRARWVKANPKNPFALQCLQACLEFWDLVSAQQIAATLDKAYAKSSDRKYMFWSITLTFLLSISTQCTDASRKIYCMLVLKQLERAADITENSSKVEPQDRGLLTEEEICLYYRVLLVHGTKSDFITRMQSPRLGAISQLREGHKLLLWETLDTLEGWAEWDHIYDLCREALNLGIDGVTHPFLVCDWRVWKRFATAASKARDSEAALGEVQSILKKFIAMSTGAPAMYKKNISLALLETTFRIPAALLSPNSDQRGLSPRVIQIGLFLDQYFDKLSAFDDVKDYVAELTIEEVKSFLEHVLPKILDEKPGKLSQITLKSLEIKLRYLLTTCPQTLSHHPTVVDGQEQHKPYQCRLCSNLTSFPCEHCLNKIIISAADTYGKMADSDLGDAIPHLDKDPRLDLALVMGLSLLKLAGLQPRTSGLAWPPLQGVKPGLFFQAVLLLDTQLQATPSDSALRLLLVQLYLLLGCTSYAYQLWQPMDVKRTIQDALSPLFFDRISTLSPGLFQGTRPLMDPLRSYYGGNLRDNCPVRIWDAFSSGSYTSIIDISEYDSKLRRSCTLMMTMVEERRATRCFGGKLDYDIDDHPLAASISDSTTLTNKTDYGSFPHLESLHGAPIQEFVRLGPELSNTRSHLSFLSEQYLDLLSFKPPKDYRPAKANEAALRDRTYIDERLAQLNSSLADYLHQPSTPSLLTGAELSYYTLTSMLAAVLLTSLTIAKTDSAAKTPLSLLSSSIRSALTGLRTSYFSSPNPAMSPTCFSLTNMHILAQLREAAVAAKHTAAFALTFHDKELARDRSGKSGLHRDAVAEMKALEMVAGKMLQEVKTHVQKLKESLGRGGWLDRMLDWIFGGDESGEDDQVKKAVQEVVNSGPGAEDWVGRVLESWRETVKGWGMVRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNR3</accession>
    <name>A0AAE0NNR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_173494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="287"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="739"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3384916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1574" mass="172432" checksum="D56AB628623A74DD" modified="2024-05-29" version="1">MEQPSSSSKVTVEYYDPHDVYKLLAPGLIPRLPLRDLHWQSHAGPVRSIHTLHVEIVPAGLDYSSYLTPLTPNPPPSAGATATRAESAAIITTRDDGFQTAAVGGRPGDTEHVEPAAATLRPPGPAAAAKERRHQIPGLRRTPYLKVLLVRCDDNDTYKATARAEIREWIKTHTPPAQGKLVNNAENHDAFEWMIIHVVIPNTVAATQPRVTGSKAQDSSSDASIKASAASRWRGGSSSLLEKLRADFNGSSKSSVDRVRQIRIGINDVPYDLLPRVVPAVPTGYHETEQDSDNAWADLIGKFKELILSSFDTRVTQYEEDIKERDGQRGLPGWNFCTFFILKEGLARGFESVGLVEDALVVYDELSVGLDAIIQEQAIAGSAEAHGGALLPYTDELKMAAEKALNQIARGNMEFDYEEAVDLQSAGKGHADYFDKIPIGATKKPYRELILANNVSLFDFRCYIFARQISLLLRLGNAWSTREELLAKLREQQELVPRGVAPRAPPPKPTDESENLSQLAEICRRTLEFVPAVSHVSRQDIVSALLSAKSGKGDYEKASIDPVMSEVVDNLVAAFAFSVAQQILAQTSTKALPIPPSVFPERGGQEPKTVLPEPKTMIHPARSTSLSIRPGPQTPQSPVRFFSGFGQRLGASDGLVSSPYLKAGFEELAARRAELYALSRNILEECGKKRGWTDGWSSAPVVGESGVTELQDVSLDDDDNATETDQVSKENIRLQTSIAGVESELLRTALDNKDDFYRLYETLTDKSLRHYSVAGHEHSVKANRADLAVLKFQLGEYGEAADYFHDVIPFFATSGWSLLELSMLVMYARCLKELRKMDDYVNNALRQLLSKAAFAEGDRLQQKSLLRNGSKSAGAFPETSAISGFLADFLSVSTSLDQAVQVPLTNFFGEVELAAPPVYDDGMDSYSLFFTLQSLLVDEFEADVVSVRMSGLAVGGNKEIWLQTKGPAPIKPGLNKVQVMSTVMMAGSYEVDQIRLSSKNVVLFYDRVLKQPVDKITPIMTNPRIVLYQRSSSLDVRLAATKDLQLDKNNSLDLEVLTGWNDVISCEVKIKAATAGLRLLMGEATAPGPIQPSKRSEGGSFTFGAVSAKSPVKIRFPFTVEQDLLNVSVKAEVAYSTENGSFSFSKILSVPIALELAVNVQDVFKHDALFSRFTVSTASASPLRLFKSELVESEIFESHFGMPPSHPIMVFPKQPASLLYKIKRKTGTKPVAKAKRSLYLRLYYSVLQHEIEALFERLISEGLTGTPLQEYSKLVVSRVLIWVQNKLSGYELEKAALLGELETGFLKDIKWERQFREVEPTARARRGGPSAELAKFVLDWSTAHPKLLLPHPEPGSIQPHSIIIPVDIPPITIVHTADIRIQESLQSIDVTDGYPTVCTNQLLPATLHLRWTRRWDTAGVDAQGKAVPTARSRDLEFGYEITAPSDTWLLGGRRKGHFVIPAMENPDGEADMTSTADTEADIPLMLVPLREGWLPFPSVEIREVKSSGGADADSSGAALGHGHCETDYRNLGETIHVIADRARVTLSLDASGPGGGPLVLESESAGLAGGRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPE0</accession>
    <name>A0AAE0NPE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase/beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_522606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPE0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="658" mass="74634" checksum="DE0E4765C0D03430" modified="2024-05-29" version="1">MSTGHSDHLKGDPYDLQLGDPIPRREPHALSVHLPTWKDTLGWASRQADVVGKMTTGYPRFFIHHSVVRLTKRIILEVNNAKRHPNDDEWNYWYSLYRNGPLEPSEQSGYLERMSQWPLVSGSTSSDNEYDSKDMVQSYWHGLLFSTTRHAQMCCRFLKRQKRQPTEIQAWKVFWNLARPQPVAMDEENTGSVSNVQKTGSDSDSKRGASGEKQEVPDPEPGSNLYLVMFPASCLELVAASNSFWQHTGFGISSRRASHWLKFAPFLSPPQLDFHRISEFHEFRHWNAKTTIKQRISSALLCENHHQNIWLFPSGMAAIAEAAAAVQLARRSPCAIAVFGFAYVDTLKILQKVFGFKVVLYKYSESEIDRLEDVLRSGTTRIGALFTEFPGNPLLQCPNLPRLRTLSEKHDFLLIVDDTIGTSANVHILSHCDVVCTSLSKMFSGKGNVMGGSLAVSLNYLDPTNRYIKLKAFVSALNKLQNTSREHGDNNGWFFEDVITMEHNSADYWDRVHEASATAEYIADKIRHVPCIARLYYPKGGDSQRMYDAFRITNVRNMYRDDRKGGYGFLMSIRFTRPAYARTFYDALTCAKGPSLGTNFTLCCAYTLLAHYNELEVAKEHGVVEDLVRISFGLEDKDRLLGAVVKALRIAYHSQSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPY3</accession>
    <name>A0AAE0NPY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPY3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="25489" checksum="AB2299383C8EDA4F" modified="2024-05-29" version="1">MLDVLAIARRAMQVVEPEPDPRHRKPEPSLYHMELEQQRAREHEYQRLKKLEQYREEYELRRQRELQQEQQRVQQLELERQQQEQQRQERLRQLSDIHHVSLNDPNNPKKKRWGPPWTLSEDQTLLALRVGGWVWLHIQHDAFPTKTLDACRKRHRNLVDMRSVEIFEKSETYGKVAQEYMSSRRPCGSHWPAGAERDGRMSKPSQGLEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ16</accession>
    <name>A0AAE0NQ16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_393639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ16"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3385454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="88032" checksum="705E7789372716A3" modified="2024-05-29" version="1">MASPKADAPQVGLKFVGHDAIGLPVKRKQVHQACSACKRRKVTANALAFESSSTCKKRRLTDNDVNPEKPVPPTRRANGAKRHSTTLDRDASDAASQLLQFRSQSIDILPITPSTAGLQPQPDSAAPFLGDLNPEGILIEGTMTSTSITKPAVQPGKTGPGIWFEAAAAGTTLPWINAPHYPDVPVTTSIDDDTRRAYLSLPHSGDTRIEVPVANIGNFLKLGRTAFVQELAYVVRPSETSWRALKRIYMLKIHPIFPIFEESSLMISQSDSIIDDLVKAAVCLAAANDPEAAKHLFLNTIPKDPGEGPGQPSRIPVLTAYPQYSKTVVKFIKEGLPHLQSSSPSENVFSYIRIAAVTCLFWQPEPQCRFAPLDLFAVVVRMVHTYGIHIDPAVQQAYSEPGSEGIDHGKIRLFKCLYALDRLVSALSGRPVMFHNYDLLTVPQPEEKDEPSFKLFMSLIALLDKVIELYRPKPEFNHIDVPVLERLILEAGAQHQPVYILATLEVLYHAICVLSVRMPRDRFKTSPDDDAQLDEIYPHLPPSVLNARRSHSSDRIFDGITGHDIGPMPWVPYALALSLSVEYRKWRFSRTPMFRTRAGETFKKMLPVLKKLSKIWTSARINSDLGDAVITNLSRAEHNMRRNKGQASTSRTQEQESTHTDVEPTHGVAIAHQFDVTINPADGGVFDTFNKNQMPDPATDSGIPSGPQPGLSTGDTSSTAASFFASSNGLGSELWDDQGSGTSFGSVPEIPDETLFQSLDQNLMNTVDWSFGSNLDPGWPLSWSEYSTGGPDYSTGGFFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQC1</accession>
    <name>A0AAE0NQC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_433374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQC1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="468" mass="52516" checksum="8F6A35F350252205" modified="2024-05-29" version="1">MASQDKPSASMLWGGRFTGGLDPLMVHYNESIYFDKVLYKQDILGSIAFARANAKSGIISQDEFKKLEQGLHAVMKEWEDDKFVIVPGVDEDIHTANERRLGEIIGKDVAGKLHTGRSRNEQVATDMRMWLRDELRIIEQHLREFLNVIAARAEKEIDVVMPGYTHLQRAQPIRWSHWMLSYGFAFASDLERLGEVIKRVNRSALGCGALAGNPFNIDREMMSEELGFDSLLWNSMGGVADRDFVTETLQWGAMLMQHISRWAEDLIIYSTGEFGFVRLADAYSTGSSLMPQKKNPDSLELLRGKSGRAFGHMAGFMMTQKGLPSTYNKDLQESVEPMLDHVKTVSDSIQIANGVLATLAIQPAKMEASLDPFMLATDLADYLVRKGVPFRETHHISGRCVALSEQTGTPMNELTYEQLKGVDARFDKDISEVFDYEKSVEMRSAKGGTSKSSVLEQIKVLREMIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQK3</accession>
    <name>A0AAE0NQK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_449691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQK3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="45"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3385665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="441" mass="48077" checksum="37AB994A7722BF14" modified="2024-05-29" version="1">MKTTMMMAARAADPPPADIMNENRGGVMIGLSVAFIVLTSIVVPLRFYARAFRSTSFGLDDGLIIAAYFVNLALCGVGIALVLVGGVGQHVAAVQLRDPHALTNWAKFVLLFEFVYFTAVALPKLSILCLYLRVFNWTEGPMRRATQVMFGLVLATWFSMMVTASFQCQPLAYWWDPTIKGGRCIDVQAFYHAQSVPGFVLDIFIMALPIRTIWSLKMPTVKKVALVLVFLVASLGVIASIIRAATFFNNAALQDRTWASVLLCGWSVVESGCYIIANCLSHLRPLISRFAPQWIKNAFQSTFKSISHSTSSHPASKVRSHTTKKAAIAGNAHQEEDTLELRSMRYKEGGYSTPSMAHEESFPPVGGGHSGTGIYVHIDSPAGGTYAQPVPRTSATDGSGAETPGWVGQEMGGGIQVTTEVTTRICRQKSLGYMERSGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQS8</accession>
    <name>A0AAE0NQS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQS8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="202" mass="21674" checksum="7EB46ADB424AD1EB" modified="2024-05-29" version="1">MNRAARGPVIARHILRPVTNAEHTSGGPAAQMSDVGGSHMACVPLLVTTPQREDTIAGGATNDQISHESGNTATAATVGENRPARQPADDMTLAEDDWDEDLGDLSLEGLFTLFEWDTPNDWRWHNHPSDGQAEEYPGIAGGSAPQLETAPQIVESNGSPSNGGQVSCEYTDAGENGMEHLEWDTPDVLSLDLLDMLHTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRU9</accession>
    <name>A0AAE0NRU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_365588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRU9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3386480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="80" mass="8916" checksum="F379A9CD85477335" modified="2024-05-29" version="1" fragment="single">EESKRTPLHQAVIMGRIEVVEELLRHSECARFIDLGDINDRAAIHEAAARGHIDTLQMLLHSGAQVDVHDKMGMTPLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NS30</accession>
    <name>A0AAE0NS30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_139771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NS30"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3386698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="508" mass="56327" checksum="1E55549849E81D2C" modified="2024-05-29" version="1">MDRKDRIMDPEKEIAQQVEVLGHSSKDGASSDGSVLPGDLVWTEEEETAIRRRIDWHTVPLVTLLYMLCFLDRANIGNARIQGMEADLNLGGPGYKFNWALSIFYIIYLLVEVPSNILLKHIGPRFFLPLLVCGFGLIAMCTAFADSFPTLLGLRSLLGVFEGGAMPGMAFFLSCFYKRNELLFRIGIYVSAASIAGAFGGLLATGLSRIPAWGAPSMLIHTWRNIFFFEGLITLIVGLLSPIWMPTTPSDAYFLNPRERMIAAERLNRENRADPNAKVTWNDFKRGIFCIHNYTCALGFFLINITVQGLSVFMPTILLDLGWTQTQAQLYSVPPYVCACLVAVGVAYASDKTKVRGIWLAAFHTLAAVGFAILRWVDNPNIRYMAVFFVTIGAFPGGPGFLSWAMNNSAGPSVRAVTSGYVVSLGTMGGIVATWTYINTDAPRYKNGHTVNLAGNLVVVFLALFGIAYCTWENKQRAAGKRDHRLEGLSQEEQDQLGSRHPRFHYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSA6</accession>
    <name>A0AAE0NSA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_138990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSA6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="169" mass="18867" checksum="E562505239F73443" modified="2024-05-29" version="1">MVSLGRGSKEGKKHQASSPNHIVNLFSFIGLSIIAFFRSRPAPSCRIFCHDKSVRQTLLFQRDSNKSPPKENSSENTRTPECLVHVILFFPPAKTGTAQFVMDALTCRFCLRVRGNAGHSEFSPCNQLSMREIEASTRPRSVILTSPPPIPRKGRHTVFFGRVHCISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT75</accession>
    <name>A0AAE0NT75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_469714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT75"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="542" mass="59607" checksum="ACF51238607F2E2B" modified="2024-05-29" version="1">MMRRRRIPTIAVHNNLIIPQIAPSRRAQSIVAIAIIPLGAAFLLLQFGDSMRWLSVAGLLVPLFISGIEGAIDLDWHPPDQTLINNITAVISGPGVYGFIYNSSDSPRYGTYNWCNMPHVRRDEYVPAPSEYELVYVELIHRHHKRTPYASNSFPVEPYRWDCDDEAVFSYASPLLQEEQQQQQQRSAVPIYWNFQASSSQNPFSPGTGGWTGSCQFPQITSGGLDDSFQHGVDLYGVYHSLLGLLPSHSDPPESWRQKTSFRVTTNTITSQVAGMLLGGLVGPAVPKISVTVQPAAIDSLEPRYPCPRAAALMSIAKSSAAWKAHLRAAQPLFDTLDAISGVNPSDVSFHESVDHYYDNLSARQCHAKPLPCHPNAVSERGNCVNQDMADAVYRLGHWEYSYMYRDAGPEALAAAVAGYGVWVAELASHLRDVVAHDTKPDTVWRHNIAHDGSLSRLLAVLQVDEMVWPGMGAEVVFELFRKKEKGDGSGYFVRVLFGGRVLTSSSPALGRMNLLLVETLLGYFDGLVGVDAGLVKGKCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT81</accession>
    <name>A0AAE0NT81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_469731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT81"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="226" mass="25782" checksum="82AF4BD3E9ED15A1" modified="2024-05-29" version="1">MRGQRLASKELFCQRTCACKKWGLGCSSTCGCGRADGKCLKFFDKPDTLSLLRGIFEPLDPPRLMSPCFVTYLQQHEFLHSGDYGDTIAEEMLSKVLRTLKYDHDDKRSSTAWLKAWEQVKARPVDDLERMKLRRIILVAALSYNPPQTPYVFQGWFSLCAHSQGWGNYWHCPDCKRCALAKSWHVLLARRRGKCVTCALFREPNVIYSGSREAGGNIHRALSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUZ9</accession>
    <name>A0AAE0NUZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_471387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="303"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3388049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="590" mass="64710" checksum="B4FE75B58DC5D95F" modified="2024-05-29" version="1">MSDPVSPGLSSRLSKLNLFKGSRRRNAEDNEDKGEEVDAGTVAGGGHSTRPTDITEHKLRVSEALQLFLDKQGVVSRSDEASLHALLEKPHVSVPQHVTDRSHPLPEYFISSSHNTYLMAHQLFGVSSAGAYETALVAGARCIEIDAWDNPDNHDEPKVTHGYTLVSNIPFRAVCETVRDVVDRERAQAPCDQGYQAAPVVISLENHCDAYGQLRLVDIMKQVWGDRLLAEAINHDMPDEHVPLEKLGSSIVVIVEYHLPNEVDSSSSSSSDDSSDDEEEKKAREDYKAKKKAAGPTIIVPELAALGVYAQSVKPVNNSWYDASTDGTLKDGPHHHLINVSEAGLAAHLSAPHAPDIARHNARHLMRVFPKGTRISSRNLPPVAFWGLGAQICALNWQTFGASMQLNEALFAGTAGYVLKPPVLRADGSGVITSSRHNKILRLQVAGATDLPLPEGRKDDGSDAKPYLTCSLYYPSPTDPSGVVIEKRKTGAYRQHKALSFLHGGDEKNPPQSDPLWDETLEWEFDDTSELVFLRMLIKSDDSFSANPVFAVAAVRLLYVVPGWSFIRMLDLKGRETKCSLLVKFEIGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWP8</accession>
    <name>A0AAE0NWP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_445421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWP8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53609" checksum="87A8A9AB2146B063" modified="2024-05-29" version="1">MSQPTKAEIDINIIPNEDLKTVDWQQKAGLVSELDRDAAISNWAGLDKSSSSSQLPMPSFQEKSTLGTLNTTRRVTIDLNPIYAPMGMAKKPVSVWGVTYLDINTSKLKDGVLKLVHPDGDPERSLQEAKREHGQMWLVWTKIRLVSPQAKVLPMASPADTALVMLDKNQFKDIKHPVFSQNPKFQQQPLYGIFMPRYGRDLQNAKQPKFSKWPEAEVLKVLSSVGSALQAFHLAGRVHGDVKDVNVVLDNDNYLLIDYGDAKASGSVDVAQSTDYIPTADKNPEWRMASEIFYSPQVDRMMLLFMCCAMLAGIDPRGVDARPLGIAKAVADVKDSGLKKGLVQLILDKGETTLSDSFLQARICNIISSVASGKDMAPFEAVINVLPPSGNTKPIDFTVRGIPIRMQAEGLKNIATAMSNSRGVATEYELALHLGLTTRFALDFLKTRRSITVKKDGQSKTFLVQGKPGIRAENVKEIGIFIAKSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWQ7</accession>
    <name>A0AAE0NWQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_463062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWQ7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="437" mass="47746" checksum="AC3B26E3A113E38B" modified="2024-05-29" version="1">MPSAVRPDTASGGLRVAIIGAGITGINLALGLQARNVSYTVYERAPGFREIGAGIGFSPNAERAMGSVNPEVLQAFRRVANPNGEDYFQWVDGHDTAELLFRLHVGKDGFQGCRRCDILEEWAKLIPPERVEFGKEIDCVTEDAKGLVIQFKDGTADTADVVIGCDGIRSRIRQLVLSNPKDKNAAQPHYSSKYCFRALVPMPAAVAAIGEYRSGTRFMYNGPKAHVITYPIGNNSVLNMLAVLSDNAPWPDQTKHTLSGSKSEATAAFEGWHPTVRKIVDLFPEQMDKWAIFDMAEHPASTYVRGRICVAGDAAHAAGPHLGAGGGMGIEDALVLSELLAKVDNLEEEAFRGSAGAALIEAALKVYNDVRYRRTQDVVQSTRAAVDLFQWQDRAIGSDGTKFGQQISRTFHHVWDYDVDDMVREALAKLDETVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX55</accession>
    <name>A0AAE0NX55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_556587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX55"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="66154" checksum="960F45305E5FBD93" modified="2024-05-29" version="1">MSHFHARDMRGPGGRSKELLKDTHPARRLRDRDETIENMKQTVDAAPGDRSWAEHLNLLAYQASDRYDKTGRNSRTGATTDLEEAVRLGRQAVDQTPVSDPWRPTYLTQLVDSLRHRYVGGKGAMGDLEEAIQLAEQAIEITAEDRSTDLASRMQHLVMLLCHRYQSTHVDADLERATELARRTVDTTPSDHPERAAHLHSLGAQLGERYSMYSRKGANVAANLQGAIYYFRSAVGQPNSATMEQIKAGAAALKLFTAADSGPEPAYEIASSAVGKGALVTLELREQGRGIVGTSLQEMRTDVSDLGDRYLELADRSSRLREELDAMVRDAGRRLLDDSDPSQSESWKVRTNRRYEVGNEFDRVVDDIRRLPGLGEFLRPPSEADRCAAASCSPIAIINVSQRRDAILVEQHQTRALALTGLFTADIEEKLQGGIPGSPGVLQWLWDTVAGSVLNALGIDRPRTGGNWPRIWWVPTGPRTKFPIHAAGHYVRRSLETVLDRVMSPYSPSIKAIIYGRRRRAPLADILASAPALLIAMEGTPGHTRLPHATTEITALRGICTSMGLRAVEPRRRKQDVLSHLRESGCAHLSLCWSWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXS9</accession>
    <name>A0AAE0NXS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_427846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXS9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="130" mass="14244" checksum="A4FA364BD3507DF1" modified="2024-05-29" version="1">MATVTAKYQLVFHVPPRALEACKQLVFEAGAGRQQPGSGSNNYTECCWITRGVGQSRPNGTVDAPVQHEEESTVETYCFGEDVARRAVAALKTAHPYDEPSYSVVKMEDVGCRLAHRHGAPIIGFYEMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYA8</accession>
    <name>A0AAE0NYA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYA8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="165" mass="18434" checksum="DD9FF4CDECA22DF0" modified="2024-05-29" version="1">MSEPEQDYFLPDEWDGKVVLLFNEATGTLMDLGGGQSWNGNPVIGWEYHGSSNQQWRLQKVESGVWGAWVLRNVASGTVLDLNFGDANDGARIQGWENGGGSGNPNQEWLIITKEYNNPSRCILQNTGTYTVCDMAHGRRDNGNPIIGQHRLGWNGNQLWRMQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P035</accession>
    <name>A0AAE0P035_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI/SNF and RSC complexes subunit arp9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_429567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P035"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="73945" checksum="53BEE557C1840D02" modified="2024-05-29" version="1">MSGQTGKWREEQILVICPGSQTTMAQLGCGELTPPAHRFPTRMFKDEENSNWRPYHTYKRKKETAAATTNGAARGDDEWEYVEDTESVEGAVYPIQAGRIANMDAFLAFLDHVHSMLTTTYHNTPIMLMASPQWTRPDTETIARYIFEKTRTPALCLINSGIATQYGLKWPNMTVVDVGYEKVDVTCIYDSRVVSHKDVGSYPGDERDISGGEVFTRKLESLLKGKGFDHEMAEQLKKNPICEVLPFAPDSPDLMELPVEAAAAPAAAAAEAPKFVTSVVDVDDGLIDQEIEDDGVLDVANLVVSGQTREFLAKKEREKAEKAKAGRKGKEKEAAEAAAAKAARLPNSKRPRNIFHLEELVTEDVPIIPTATTSTTATDAAAQPVPSAPAEGTTSAPEAPASDIAKPEQDADRKQLPTMTSDDTKPEAPLTVPPAAAAPEPAQQLTERQTKRVRRDIEIGLERFLFADRAEIDRIVTAIYRAVQGIEDMYMRPSCWENIVFVGNGARIRGLKDNILQTLQARHLISPSSATMFTSELPSNMGTPSGTGSQTPTGSFTGQLPTTSSVNPLLQAATTASLGIPGGPNAAAAAASNAGDAGGPSHHFHSQTPTNIKLAALPTYLSEWTKNGFEEAMFLGAQVAARLAFCIHNLDAQGVESQRLMSLNRVDYNELGPKGIRSHSMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P088</accession>
    <name>A0AAE0P088_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_124411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P088"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="450"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3390859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="995" mass="110243" checksum="D1610B6F2EA24548" modified="2024-05-29" version="1">MTGAPRFRFLAIAVIFHLVYIFSIFDIYFISPIVSGMRLFQIERPETAKAPADRLVLFVGDGLRADKAFQSHPEPYPKSNEDLVPRPLAPFLRSKVLEDGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKMNPVDFDSLFNRSRHTWSWGSPDILPMFEHGAVPGRVDAFTYGAELEDFSQDALVLDYWVFDHVKELFAEARTNKTLHDALKQDKVVFFLHLLGLDTTGHSYRPYSKEYLHNIKVVDQGVREITELIGSFYNDDRTAFVFTADHGMSDWGSHGDGHPDNTRTPLIAWGSGVAKPQLYPGEIAPGHDEYSSDWALDHVRRHDVDQADVAALMSYLAGVEFPVNSVGELPLSFLTADVKEKAEASLVNAQSILEQYRVKEEKKKTAELRYRPYQALSDNDLSPENRVAGIRQLIDAGHYEEAIEESAALMKIGLGGLRYLQTYDWLFLRALITIGYLGWIAFALTTVIDLHVLHGRLRPSRTLVGSLVFSSLLAALYASFVISKSPITYYAYAFFPVFFWEEVYARRNSLVAGRKQLFGHVTSGGGIASLLFNGALYVGILESLALGYIHREILTILFILGAFWPAAHGLSFLQKHASLSTTWFLSCLAMSTFTLLPALKTEDVNLILIGGGLMVVVGILYLILEDFVLADFSWTEKPASRQHHLSRTLVGIQIGLTLLSMAITRSSALSLQAKQGLPYGNQVMGWVVLVVSLLMPLAHRLQPNNHYMHRLLVIFLTCAPTFVILTISYEGLFYLAFSALLVSWVRLEHVVQNFSPVAPAINKEANGPITESGAGVKLPAPFRPLTLYDARVALFFFVLLQAAFFSTGNVASVSSFSLESVNRLIPVFDPFSQGAMLILKLMIPFALISANLGILNKRLGVAPSALFMIVMAISDILTLYFFWVVKDEGSWLEIGSTISHFVIASLLCVFVAALESVSAMFITGVEVNNPVARVITNGAVAEMLLEKTNEAVDQISATVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0D0</accession>
    <name>A0AAE0P0D0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_126601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0D0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="326" mass="35598" checksum="F462518C0D0415BC" modified="2024-05-29" version="1">MSKRTVFTTISPLPPNIPRQLVIEFLHDHEEMIDLNPLVIERHPIKPPAHCPPDEMDCAWYSLTDKISYLPGGLMSGDVTYTCAFHDIPTGVQTHCYAPAGLNIQGKWTLNGSLPGEPVQPVELGIGAPATGLYLREDVNMKCNVIMTSFVKRTLKKSHATLVDRLKSKAQLAASDPAPIIGGGSTANSQPGFGGQAAPAPPSSSANDAQNHWNPTAIGNSPPRQAYGQQSQQYYQPPPPQHGSNQQHMQQYPPHPHPNPTPQPQQLYQNPPPQGGHDELFPQPLRLSHSRNPSRQQEIHEDSPTLPPTNNKAARAPSKSFVAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0J6</accession>
    <name>A0AAE0P0J6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_467369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0J6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="64"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="290"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3391151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="439" mass="48368" checksum="DE73598D1445935A" modified="2024-05-29" version="1">MRAPRCVSLRLSPRTFILSRGHNGVVIGTISTPTLTAHRCRALSSWGAPPDDAPRHESSPDDTIYILGVGRLGQLVAHALAQSKPQLPVALLFHRRERVDEFKAAGHAIECTTPPPHPTTDKQTGFRFENLQPPPLEDPFIKPWKTQRDRPLPAPPKVPRNLDPIKYLVVATKAVDLQHALGLGPIRDRLNHDSTILFLPHGMGITDLVSTHDFPDPKLRPTYWAAICSASVYSTAPFSIVHAKRGPLTVGRVMTPDDDAGRHAQENNHLIRQLLQAKALETTVVSADELKEAQLLNLVVEAVVSSLTAIHRCSDGELLDDPSRLTTITKLLEEVGPIVRALLPTSLDDRRRRKFSDAGLMDLVRAAASSTAKNTSPLLRELREGERPDIDAVCGYLVKQGRIHGLPTTLIRLVYKMICGEWFGNIPRGIPGLKPKLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0R7</accession>
    <name>A0AAE0P0R7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_467599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0R7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3391259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="537" mass="60742" checksum="7116A777B0232D63" modified="2024-05-29" version="1">MRLINATNYQLQEFYGDQIPEYVILSHTWGRDEVSLQDLQGGNAPNGIGFQKIRYCCGQAIADGFQWAWVDTCCIDKTNSVELSEAINSMFQWYRDSSICYVYLEDVDSLSDDPDFSNDFMGSRWFTRGWTLQELIAPPTVEFYNHNWDEIGTKSSLRERISSTTGIKTRVLQGDDLSMYSAAEKLSWASDRTTTRVEDIAYSLMGLFGINMPMLYGEGNKAFIRLQEEIVKSHFDQSIFAWTAPHPHPGYLARSPADFRDFREHPDRLPPRGANPNFFDVNTNQPPPTVSSRGLKATLLLRSADNVPRRCLAVLYWIGEPPRTPITAPPTTFTAASLICILIEQNAHDSMTFTRLSPESIRLVPVTEISSFRWTPIYLEKSESYERRQGGEGLEAIQLGMRGAADSDSILGVYPLDLWALEREPTYVVRRPAGPPESQDGALLIYLGPTRYFLVYFGMCEGAPWCVVERIPEGVAQAAFGTDQIVRRFLRTEGMANARSDRHIEPTRREVSAALRRVPAASDGTIRYRLQMSFRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0U6</accession>
    <name>A0AAE0P0U6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_520381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0U6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="326" mass="36527" checksum="EF0A79FFBD2D285B" modified="2024-05-29" version="1">MTSAWIQAVLATIFALLAAWEWFLRQKHTVPGKKLHLVFYAFNQALDVFVNGALILSLCINVAAFALMLQRKDVSDGTQLALAHDMVVFSFSACLFPTIMHEQVHGDSGRTGSRYLILFIDIILYLVVGNMVPIVSNKFESTDSWEVYCFWDIIPTERRFTSLIVWVTGILFWAWVLKIMDVYIIGVYGFLAWYILITITVIRQLLLQRSGFGSEDLRWSFGQILSLGTWLPVLIELYYLFKKGPPETGEDGIPNGQAASNDPSSLPTSNSPFIATDQQSQEASEEDTGLLLENMQRPGMSSQSVSNASLLSLESGSRQTPRSTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P411</accession>
    <name>A0AAE0P411_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_387730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P411"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="358"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3392807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="61665" checksum="52600453A9268506" modified="2024-05-29" version="1">MRVNYDRERKAFLALRQQSGVIQSFGCYESRVDPKCHTYNIILEYADFDLYEMMMNEAPPVSPNEIKSFWESMLELATTLKQIHQVDIHGNKYNLWHGDIKPENILRVQDQFKLADPGEARIQQAAPEDGTRPPKAEAYGGTRTYAAPEKAEWLDGYATDPSKILQNSDVWSLGCVFSVAATYVVLGSQGVIIYNRIRQHSRPQTKTEKGTLVQDAFHDGRNALALVRLWHKYLCNAVRGTDGFTARVLEMVDSKMLVMPPEERWGAEEVSQQLSALVHDPDVNPLPVPEDIEQILQELDLEAELTFESSNNVSRADSEPAAQHLQRRGERSINSIIATPFKSGAALFSTQIMPTAQRSIYLVDNGSSMERHWREATHLLRILVWRSLGYDDDGMELYFTNPDTRVLVKAAKNQDVMDFVSAMNKARPNQPGQRGSKTNLDTKLQEIISHYTTAKRSSAKEKRKTIIILTDGIWEGMSDDELQTRMLETLRRLADLHREDVTKTLEDIRPITFQFVAFGDNQKALDRMRRLDDDMEKLGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4B3</accession>
    <name>A0AAE0P4B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_554243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4B3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3392745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="166" mass="18931" checksum="76C2E5F108369C94" modified="2024-05-29" version="1">MATCPASREKFEIAVVCALPREYGAISCLIDWFWDEDGDPYGRAEGDLNIKTVVQYDLGRLYPDTFITKDSVEDSLGRPNKNIRNLVAMFETELERERLRHRTAFFLQEMQSSSAAQGRREASYQYPGAAQDKLFQPSYQHKPLQSLSGALGWLTQWLSQARTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4I0</accession>
    <name>A0AAE0P4I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_443456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4I0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042254411" evidence="10">
        <location>
            <begin position="24"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="53"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="46778" checksum="FBA13049BC3A485C" modified="2024-05-29" version="1">MCFTAFLLPLLVAILLPATGSNASVLLPTGGNITSLARRGVESTLFNVSTTSYLIQLAIGTPGQSVKVAIDTGSDELWVDPNCRDRTLELDQMQECSSDGTYTPKTSSSSNQNVTTAETNTIHYGKGAVKIVYFRDNIALSDTGSAAGGSSVTNAQFGVASASTELNEGILGLGFGRGANLNYSNFIDELADQQVTNSRAFSVALGSADASNGGVIIFGGVDTKKFTGKLQSNPLLPPQFTGDIHRYYVQMNSTQLRDGTTGSTKTYSNGNPNNKPIAVVLDSGSSLSYLPLTMLTAMAADFDGVVDVKDGIVVVPCSNRSLNSTLVFNFGSGTISVPARDFVVPVDSENCILGAGPSDPSSGLTALLGDTFMRSAYVVFDQTTKTISLAQYANCGQNPQTIPATGAGNFVGECDASAAASAHNNAAAAVPGHRAGLCAVLVAFAAGIVAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6P7</accession>
    <name>A0AAE0P6P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_42785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6P7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="11196" checksum="E6181E852830E06C" modified="2024-05-29" version="1">MMNHETHLSLAYVIFWLEFFFFFFFFFSHIFGALDKFRPLFSFGRANLHYTRAAGRPHSTCLSVSGKKGSSFRTVRESVCIIDWGKGEEAVASVTAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S5</accession>
    <name>A0AAE0P6S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec61beta family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_460881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="112" mass="11444" checksum="0F55859996764EF7" modified="2024-05-29" version="1">MSSPRASSPVGASATSGASTGRPLSPPPPGGARTAIRRRAAADQKEKIASARPNSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVLVLSLVFIFSVVALHIIAKITRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6T8</accession>
    <name>A0AAE0P6T8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_43663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6T8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000024">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3394354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="578" mass="62773" checksum="D1B4FF1B19FCFCD8" modified="2024-05-29" version="1">MAWSKSTRIKVMLVIDVLFFFLELIVGFAVSSLALMADAFHMLNDVISLLVGLWAVSVASKATTDRFSYGWLRAEILGAFFNAVFLIALCVSIVLEAITRFFKPPEIGNPELILIVGCLGLASNLGGFFVLGGHGHSHGPGEHSHGEGEHDHADTHAHSDGGYNDLDDAEAGRAGLSGHAHNTAEDENGRVADVLPEAAVARYTSASARTETPSRHIRFDREGGVRSEPVQRCGSRASVRSKGADRRTPVGTRHGRLTSIDDISIHPASFRQDIIDASRTRDESSSDSSEDETVTQGDTEAVEDTPLLKDHGHSHAHGYGSRSSSKRPRRNSEIHHTHNHNKPKKSAKGHGHSHGDMGMNAMILHVIGDALGNVGVIVTALVIWLTEWKYRFYADPTVSLFITLIILRSAIPLTIAASKILLQATPENIDLNDVREDIQNLPGVISCHHVHIWQLSDTKVVASMHIQVEFPISEAGGERYMELAKSARRCLHAYGIHSATIQPEFCLDSAHDHGEDAAMRLDGTALAKCGMVERDVCLLECIDECEMQGCCSVAGSSRPESSHSAGSHSHDHSSHSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P791</accession>
    <name>A0AAE0P791_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_461648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P791"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3394683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="310" mass="33551" checksum="0FA9FE16F34E7790" modified="2024-05-29" version="1">MDQDATSTSGAAPSPALAPPSPSIEAQTYLQERRGSLTLQLKRKKSAQERIDDILEGARERAEGQQSGHSSPRLQPLLAGSPRGGIYSLSSSPRAGGGPAIPEEGAEEDGVVTRQPERHHTLNYHSTAQTSHSPRRRSATPSRRTSSQACTQANGGGEEDSGEDEAAPESGRSQWRERLRYFQSIELENKGSVARDHLALERTFLAWLRTSLAFASIGIAITQLFRLNTSLAGDSKEADTLRHLGKPLGATFLSISIFILFLGYKRYLSAQYWVIKGKFPASRGTIMMVSFIAFAVTVASLAVVLAAQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7A7</accession>
    <name>A0AAE0P7A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_50755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7A7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="103" mass="11426" checksum="A553E345D738A1AD" modified="2024-05-29" version="1">MIFGGRGAVQSRECLVVRVVITRFLFSPMVCMHGSVLFPPIIPWIVVVVAVGKRMWAMASTSSLCLFLGVLPFASSPVREQILYLYQLYLWFNSANAVPVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P803</accession>
    <name>A0AAE0P803_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_533554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P803"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="627" mass="72533" checksum="6DD3C2F38B3313B8" modified="2024-05-29" version="1">MCILLRRHYWCKEMHVVPYILRCSMPFRPTVGLLDDNEVRHPCFAEFDHYDEYYPNKACFECTGGMAEIAKEGPAIRVWTTPYPRPMTEAMTAEVDRKLSDLNEFYVLALLKFLWVFLDVNFYKFSPPIQPHGIYSELPLRYVHEREPDDVADSAAHAIWELTCPLEERHGATAMLYYDENDEGQPDGEAWLDRYEAYEEDGNVECGCLSTNKPMLYNFAKHLRAVISTDCLNKIVTSDSTGQRTNADYVEIKKAQDLSLRVFDNFQHNLRKLRARQPADQVPRTLHFHHPLTPTTLNGRNRIAFQRFAAAEAELRARSQAATTADELLYTRRREARVALFNIFYAFLIMDHGISVYRIPDIANMLYEMLVVDRGPWPVSNVQPQTPHQALLDPRQPQRAWFTNPDRDPNFYVGKIRYLADWGGPSVMRWAVQFLRTHLNVYQWTAQTRKTWRVWVEREEGYRLREVTDGLVAFADTLPTKDEWAAMKAEDCPICGDTFQVHIDRQGVGLGGPVQAKLCHFKGADHWVGRSCLLSRVLGRSGADLTPEKRTCPICRREICDIMIGENPYPWNLLTSDGITELRPIRHEIIGTNEVVRVREIWARGVEDTRPIDQEFVTPIDPVYSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8B7</accession>
    <name>A0AAE0P8B7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_533895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8B7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="285" mass="31460" checksum="2DC82AB50ED41C94" modified="2024-05-29" version="1">MAINNLHLGQWGSAGDMPCIYKVTICSKDKLLVRKVEGINEWADLGLCVVKEFELSNEQSTFELQKREAMKEAKLLSQARHRHVIKLCGTYSIGPDESSDSGESPWYGIIMEEANSSLSTYLKGIVDVPKSWFGCLVDTLAHIHGLGIRHRDIKPENILVVRGGKKGIPIIKLSDFGISQAGLGRTTPTTIPALARGRSESFCAPEVQHGSTRGRAADVFSLGAVLLEILIATSCADERTKLARIINQEGSQHYAANVEMVQQWMEEELKGKLDADWQRQILSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8I8</accession>
    <name>A0AAE0P8I8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate Esterase Family 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_534007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8I8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042271813" description="Carbohydrate Esterase Family 3" evidence="1">
        <location>
            <begin position="28"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3395278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85279" checksum="1197B5A2EB7F67E4" modified="2024-05-29" version="1">MVVLTRLGGAVVAAIAAGLFQAGGVAAQGCVQAHTLLNYDAYSADQMKVYVNGQTVCKGGDSVGYSASDTQFCLRNHDGKATVPGCAPGYVLCTAGNGRRGTLYYYQNSILVWSKDLNMISDSLSHFQRFECYHTLGTRIWCQYALPIMNLLYYIESCIAAPDLTCSASQQKCKLCDYTGYCDQDTNNPPNPFPFAPNAAPQPSMFKAMFVDGSFTHGANGDYTWRYRLWEWPKTQNVTPEFVGLYVGTSGPALPRSAMPKPLHVLEDPAEPDSGVNDSGAYSEAVNPTFSWGHAASWGRQVAKSMNTIYGWVQTYQPDYLLGTITSMNRFVSKARRAKPNIKILLANVVHRTFIRDDLITDTNDYNSRLVTAIQGWNNAASPVNLVDVVYNYNCEPDNCQDEYDSLHPNKQGEFKFARAFSRVLVSYANISWRTPITPTGLTVWSQPEGLSASWTPNNQARGYEIRSRYGGLSEWSEPSHIGTWMSLRSWVLDGQTWEYQVRSSINVTTKPGWSGMVSGVAHLNTSTDPTTITSPLATGIRAQWSAVCAPYSLNRYEVLIYNLDVPGSWLQSYATRGTDLSITPILPLQKWAAYVVAWVSLSNGVVGGGVPKGATNVMPGSTRVPQISAGLTAVNVDATTVKLSWNTVVLALAGISSSLTTSITYLFPGAWNFEFCVSAFNGDTLQSAKLTCVLPAVYPGYETPAPPIGVAISNLSPTSIQLTWNAAPRATSYRVRVHNWETNTGLHGRWFDDRDDERIERQLSVADVVFLTTGCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8L8</accession>
    <name>A0AAE0P8L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_518361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8L8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3395299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="155" mass="16408" checksum="E938F1DC68DE8DAC" modified="2024-05-29" version="1">MVGCTPWSNSNVTTPSRIFGAVGSPAADVVSRKVLELSLSAGVGPVSAVPEPGMQGVEIESLDHGQRSNNTAEKCNCHDATPKSTMQLAICNPLAQLMVDGISRVDTANADIVAKNPDWTVTVTASEVAYNNIFHPKTRANWHIAQAANDALRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVW8</accession>
    <name>A0AAE0TVW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_206204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVW8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="121"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="407" mass="44839" checksum="CE1813C1C1FBA0CE" modified="2024-05-29" version="1">MGKSSKDKRDAYYRLAKEQGWRARSAFKLLQLDEEFNLFEDVTRVVDLCAAPGSWSQVLSRVIIKGETFGRSAWQDREAKFRQRMLNVFGSDNQPAAGEVAEIDTDTEAASMTENKPRRDVKIVAIDLQPISPLPGIITLRADITHPATVPLLLKALDPEYVHEEAVKHPQASHQVDLVISDGAPDVTGLHDLDIYVQSQLLFAALNLALCVLKPGGKFVAKIFRGRNVDLLYAQLKIFFEKVYVAKPRSSRASSVEAFIVCINFQPPAGYKASLEEPLGVGNRLPEILAERQSLLPVTAPVAPLQNSDSGAWDSAPARPQTADKDGIFEVEVEDLAPVDRYQDIRWVAPFVACGDLSAFDSDASYKLPDDHVSLDPIQPPTAPPYKRALELRRAHGGAYGRKATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW01</accession>
    <name>A0AAE0TW01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">B0H63DRAFT_396315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW01"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3381592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="271" mass="30100" checksum="9FED942717E9172A" modified="2024-05-29" version="1">MDSDHEGDEVSTGGLFADPEGFYPASPPPTTQEYVRKTNGAVITLHLVGSSPSLEANHLWNGSRVMAEHFEDHPEEVRGRTVLEIGAGAGLPSIVAAALDARKVVVTDYPDPEIVATMWKNIRGCPDLISDDETGELKPIVADGYIWGADAAPLLAHLDDSVGEEKKFDVVILADLLFRHSGHTSMVNTIEKTLSKRRGSKAFVVFSSYRPWLRHKDLVFFDIAREHGFVVEKILERKMDRPLFKDDPGDVEVLKTVTGWEIRWPEEVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW63</accession>
    <name>A0AAE0TW63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_561371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW63"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="443"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3381741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="512" mass="56201" checksum="33E6878B55877BA8" modified="2024-05-29" version="1">MSGTQSYQLSDYLEKLPATTFRKLYQQPSTAFAIFRRMLPPLAKVFVQALLYMPSPLLLSQLDDVWVKSEGRQQRDRALAILRSLHIVQITPSGKDKPQEMQLTTNFKNSMRLALEGGGSHLSFGVPSALPVDPSIDIPFLDKYSRKKWEDILHYVVNSVSVYGDIGGGGSSGGSAAGPRPSVKDLLLAGHLVERRPDSKSGIVITQAGFTFLLQESNAQVWTLLLLWLEASDHAKGAANGGRGGAMMDSIDMLSFLFMLASLELGRAYDTESLTETRRNMLPDLVDFGLIFVPRENPRQYFPTRLATTLTSSASALRSVSAGFAAATANASGDAASLGAVAGANSAAAAESKGSIIVETNYRIYAYTSSPLQIAVLALFTQLNMRFAGMVTGRLTRDSIRRAISYGITADQIISYLAAHAHEQMSRTAAATGRPILPPTVVDQIRLWQLENERMRTTAGYLFRDFESPAEFAALTAYAEEIGVLVWKNEKKNLFFVSKYEQLRDYLKSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWA8</accession>
    <name>A0AAE0TWA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit FTA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_476574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWA8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="32803" checksum="4B29AE5786AF3F2F" modified="2024-05-29" version="1">MGSVVKANRQLLKSKELPPCEGPKIAMFAHSRAPIEWLELLEKSTPESENSSQGFVFKVEILSKIYALKVFKFYDPSTERHIMSEMDGQTVTDELLAFHTDPFYAECRAYGCIKKVESERRRQIAARCHGFMSLRRKDELALEEMGIDLWENYPEDHEYRAQAEGSPVRAIVKDFIETAPDHDDNSLDLRTLKVILKNVRALNKHGILHRDIRAPNFKAGLLVDFGSAWTKPHCIMAVVPASVSEEWEWDDLADFDEMVEEEGFSLASVRALPNTSYLKRLRSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZB4</accession>
    <name>A0AAE0TZB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_432625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZB4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3385012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="47197" checksum="E52E114A2116869D" modified="2024-05-29" version="1">MGDVLIENPANNVLPHKKTVPSTIPSIEHFEGVPIEGGDDYATLKRLQRQLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGVDEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTANVKVIMATNRADTLDPALLRPGRLDRKIEFPNLRDRRERRLIFTTIASKMSLAPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQVDLEDAYSSQVKGTSDENKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZH8</accession>
    <name>A0AAE0TZH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_472301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="777"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1298"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1338"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3385074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1704" mass="182041" checksum="759EDA5B34EE63A7" modified="2024-05-29" version="1">MYNANGQRDVTRPYQVPPPPPPMSPPINNNINNNMISLPPPPPRYPGAPGMLPPPPPPPNSSLPASALGGAPWTGAWGRAYINIPPPPPGGAGGGLQAYNPKLHAQAIAAAAAMAASPSPGASLGMIPPPPPPSEQMSATYIPQGGDTYGEGVGIPGLGLADDNGMGGWSTGSQFEGGAGTPLDDAPGRDRLWAAPMSNMSNISNRGSSTTSNSATVSAIPPELAAQWPMDKVQMWLQANQFSRDWQETFKALHLHGAQFLELGSGHGGRGNFGMMHQQVYPRLAEQCSKSGAGWDQPKEREEGKRMRRLIRGIVTGRPADPSRASMGHSRRESAIASVASSAGPDSADSPNTPIKAPGPGFGGRRFSQSRSTTMPMLGKAMSSDSNHRTIMKNIDIDSTRRHSPSASESGEAGTFRGQTPLGRDSPSGSPNPSSALFPSSTMGNLSASPHSSRFGHRSRNSTDSVSSNAAIYGSGVPADAAAMLKSGMAEMINGTHLSNGRRYGQDGGRPSPHDGDRSAGTDPPGSAKGSTSFLSFLSRKKRKEEGGLGSPEDQESPTSPAVSFKPNSLGSRAGNASETSLERPGSSFSTQEYSYASSLRPKRAGGARAFVLATADHWNYRMVDVTDVETAAELRQVVCINLGLPVEGAHIYQTELGRFEHEEPLDDTKLTTVKKEKADAVGSLKWFVRLGDAQQPNAYQSKAQNNLSASFMPPGMAMDEEAYARLNGQRQRSSSSPPTSRQNTISAKDRDEKMLTIEANEYRAEQLRKQQEYLAKRKQAMKETSPSIDPSYGIVGRNVDFDQPRHSPFEDKKLDNLFPQRKAPAPPGDPSATLIKANSLSKKTGQGMRLSQGSMDGGHQKRTSSDLRDETLFEKQRRRPPGPSPSGGIHGLLVGMAGRMGGIGHPAAGGQRGLSPSRVASTPVTNSELSERGKGAMSTVDFGQRSRSGSGSGSPRTGGVPGSPGSTTWSLKNVPFLVPDYSPGGTPLPPRRLDGDSFDGAVSGPNLPQHGTVAKMRQVARVPSPGGVSPSSRRRPSEAFASQQSGRRKSHGPDADFQENEVSFSQSSTLMSKQSAANGSGDDSDDGLFAVPISARGATGDKGKTAAASRFGGGGGDSDGNGKRPSLRLNTDRSKKSLSVAFTSPQSQSSIGAKTPAEEEDGGASARSGPSSHRRTPGTPGSEGWDSEDRDMKLSRRKSFIEKDVWANRPPTDALINNLEDFFPNLDVDQPVLEEGEEPPSPIAEADEGQADRDLANDAPPPLPGLPTSLTSNRISSIYNDMDTLGSDESTLKALESRPVSMQSLAHRSVRRSGGGLGRMKSIREVARGAHEANKRFTTSGHVSAQPPLPGVSSSTNLMRRKSTKMFHANIVQIRPERGSLHLPMGLTTIPQDSLPTPDERDTIPKRQTTFRWFKGQLIGKGTFGRVYLGMNATTGEFLAVKEVEVNPKAAQGDKKKMQELVAALDQEIDTMQHLDHVNIVQYLGCERKETSISIFLEYISGGSIGSCLRKHGKFEEPVVASLTRQTLSGLAYLHREGILHRDLKADNILLDVDGTCKISDFGISKKTDNIYGNDKTNSMQGSVFWMAPEVIRSQGEGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAVGAIYKIANGETPPIPEEIREEISPIAIAFMLDCFTVNPSERPTADVLLSQHPFCELDPNYSFLDTELRAKIRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZX9</accession>
    <name>A0AAE0TZX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_510470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZX9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041925494" evidence="2">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="241" mass="24866" checksum="8B76F9BDC69EEECA" modified="2024-05-29" version="1">MRATIILLSATAASALSDFSDGTRLFSRVHGGSLEARQAFDPGETTGRGSTCVEAFGAGYIECVPKSATRTRPLCYNPTQGQSCCDNLWGCPRNSFCLVQDLCCPNGLDAKTCAIKNSVTLPPDFGVSKTSTTKKPSTTAPSSSPSAYTDDPTLSTTESEAAPTSTDYDYDSTTTISKNTVISYPSTTTNPGTGGNYSSTSKTPSSTSSTSSTSAVATAGAVREEVAFVAAILGFAAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U092</accession>
    <name>A0AAE0U092_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_192330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U092"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="184" mass="19381" checksum="AF626A24D93DE08F" modified="2024-05-29" version="1">MSTASRLRLSILSSAALGQFEPGLPSTLPSLSLSRLPRGWGFGPGRFPEIRHARQTNEGHTNNTHTRFWPVLDLCGTLDAVATRERHRAEGKHLAGRTRDTGAYGMKPVPFGGRSVGSGLGRAETSAGSGAAGAWILSFPAQCGSHPASQPTQPALTVAPNKPLFLLSAPQSGSNKPPPMVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0F5</accession>
    <name>A0AAE0U0F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_450054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0F5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="783" mass="89009" checksum="742D325BC157238B" modified="2024-05-29" version="1">MEQPSTWRRYKQAEAQFTACVSGQHQEENVFDQDQKAPQLKSRRQKKKKMAAATAAAADIGSPPAQTIEDDDKLKVYAEKLEQLAQRVADNATPRDIPDAALNVHRDVISLRKRSHNFFTGMAEITTDPKMKDELKRSNARHAYLIRVLEGILAKLAAVVATAGGRPVEKTPSSSGIHIPDFINMFEHLDSSTGESDNKTDLFWVEQFDFFSTPETPPETAPETPHELTDDDIRMMVYLFFEDFNHVRNHLQERWCYYWFDKVGSLNVLAALTSHAMDTFYQMENTLISDLGPKQRDCAKMLRFVRQLSQMKGGGAPYFPIPDRPVNYRRNDMNEDHKQMFCMLMTLVNQASLLSGITAHLGAQPAIISAVPALLLGIEAFLTKFEITILLVFCLQVWFDIRYIVEHEAVHPFDQLQTNAKRLVEVFMSYDPNILFKGTTSGVVAQYKGNCVSLMARQMVHVFQAKDFCLADHSLEYRKRRAHQMKLKASPEPLVLLKNEPVFAGLLDLRVRLSLSYCSFLYVNTTAIVDSAVHVYQAALAADPGLPAWYLMRQHAATFPEDAPFRLGLQEGLRPLEIFGHFDNVKAARTVESEKSMYGAEVVLRRFFYKRYAGAIHKGLTKFDRAHIARLVHKVPTSWKYKDMGGDKSSWRPEANLLWMDSVLTGLIEKSRILELDYFLLHDQAVALLKDLMEAFGPDMRERVGYQEGQPLARLESVLTCVRVDLAAATENGDKDREAEILELLVRVCRESGFDKPTGPELRLCPWGLEVPALPHDRVWEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U0J0</accession>
    <name>A0AAE0U0J0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U0J0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="189" mass="21263" checksum="596F7ED480655005" modified="2024-05-29" version="1">MGWRQMTLDDLKSVMEIADKVHPNLPESEHVFAERVTTFPEGCLVLLDNEKETLIVGYTISHPIRHRQPPALDGPMLKGRLDPLAVDQYYIHDLAILRDWRGFGFATEGLAVIAKVADRYPTTCLISVYGTEPFWRLFGFQQPPGGIDAALSDKVKGYGEDAVFLEGRAFGEASMTSSIFNINNKKYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U146</accession>
    <name>A0AAE0U146_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_521084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U146"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="68"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3387006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="471" mass="51350" checksum="B7955058ECC3975B" modified="2024-05-29" version="1">MAAQVVTVGETKELRGINLIAAHSHIRGLGVDPDTLEPKTSSQGLVGQAKARKAAAVILEMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGADVPFTTLAASEIFSLEMSKTEALTQAFRKSIGVRIKEESEIMEGEVVEIQIDRSVTGGAKQGKLTIKTTDMEAIYDMGSKMIDAMTKERVMAGDIISIDKSSGKITRLGRSYARSRDYDAMGVDTKFLQCPDGELQKRKEVVHTVTLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVGEWKEEGKAEIVPGVLFIDEVHMLDIECFSYVNRALESDLAPIVIMASNRGVSRIRGTDYKSPHGLPLDFLDRVSIINTHSYNPEEIKQILTIRAQEEEVDLSADALALLTKIGQEAGLRYGSNLITTSQLISAKRRAKQVSVDDVQRSFKLFYDPARSVKFVTDSEQRLIGNDGAVDFVTNGHASLESMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U183</accession>
    <name>A0AAE0U183_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_141610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U183"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047348" description="DOMON domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="504" mass="55042" checksum="CE435FBB058615F9" modified="2024-05-29" version="1">MASGLSAALLLLALLITSPLLAVAKHVQYCRFGYSNGAADFCMAATNYQNATSATHDLYLTLTVTRSSFAGWTAIGTGPQMGGSLMFIVYGDPTSGRDPILSIRTVEGHHQPKPIDPANTGGASIRILKSKWELLNSPPRAAREITRRHDDSEHPHVAPQGPATHVARIAVVCYSCNLWRGSSISASSTSQPWIWAWNDWQQVFPGGDLNARLNMHRHSSHDGGWGKFYVDMTAAVKTSSDNLIPTLAPGVERLGTSDEPLGAGGYITSLWERPLKMAHWFIMGTAFLVLFPLGVMLMRTSSGNPFQRHWIVQLAATGLAWTGAVVGLAMTQFRLPHTLHQWVGIIIVLGLGVQAVLGWRHHVVFLQLRRRTWISHVHIWLGRSAVLAGWLNVIAGLLLSGQNTFNVVCAAIVIALESVIVSVWVYMKGRTAAKGGDQQTEAHSLMPKGEGGVNEYFALELDDLSSDDDADDIGDVKHEMQRLRRESDDEGTPRRNVDPSVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U191</accession>
    <name>A0AAE0U191_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_508773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U191"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="531" mass="59112" checksum="C283CF94F3498705" modified="2024-05-29" version="1">MDPKPDHVEGSDPEIEGAHSEKKPHHQTQIEDFQTKEERLHEFHETEGYIIDVDSASNDVAGLKLAKDGHTRLIPQPSDDPNDPLNWTRARKHLILFVISFASFLPDYGSATGAVTLLPQAVEWNMTPDEVNKSQAGNVFMLGAGGVLVVILSAYFGRLPVVFWFLIAATATAGWCAGATTFDSFMGARILNGFFSTVTQAGGLMFIQDMFFFHERARKINIWASFVVMSPYVGPLLAAFITETKPWPVPFWVYFAMSVLGLVLVIAFLQETYYDRSIPPPPRGSRIARLTGSAQWKSRHLRNTFPQAVMRTVRVVMKPTIAISCVFYIFTFAWAVGINTTLAIFVTPLYGFGPKQVGYFYFTPVVAVALGEAVGHFLFDALAKQYIRSHKGHFEPEVRLRATFFSMPLVIIGLVLIGQCFENKWHFMATSICWGLYVFGMMITTVSLSSYCLDSYPEASGEVSAWLNMSRTLGGFIISYLQVRWAEAQGTKTSFGVQAAVCAAAFVFVLILLRWGKAMRVWAGPLNFATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1H0</accession>
    <name>A0AAE0U1H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_157345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="38581" checksum="D96B30FF9B90DCAC" modified="2024-05-29" version="1">MTMQDPTVHAATEVASLYLPPEILLMIIECLGVSFFQENIGRLALFKRWYSLSLATFFTNIRYTPRVLSRLVNCKGKKLDRSRAMLKKTLRSVNIVLEGIGPGSDPSVRCFDTASNLCCFGLMLMAFPELRSVSYSAKWANRGWKGDPLQFDYLPLRSIKPYLILPHLKFLDLDLCGTAIKNQEGGLVHFCPFIQPLLSKLEGLRLKMRRICMDAVSINEDQTVTVKDLTINLYLGEVSNENPKLNSAMCCFSPKPWYWSSPIDELRHELKALAIRMPQPQCARIIHLTPSGWVHTWNSREDRCVTERTERKRSFPLLENWDKGECFSRRTGASSCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U208</accession>
    <name>A0AAE0U208_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_471293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U208"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="271" mass="28504" checksum="294296CAB71B315F" modified="2024-05-29" version="1">MDPFSITAGVVGIVAPTLHCVRLMVKDLQNIADAPGAVKSLTNDLQSVGLTLASVQALTDSQWKSLGDAVTAQSKAAITSCKTSCERFRTSLDRWTRHSTDGTLTWRDRATLGVFRQGHIKSMSEQLQNCNITLTSVASIATLHSSLRQTQAAEEIKTMISTAETEVNDAIAATNDQSAEVGAKLGALTLAEPDEGETDADQTAATKQIAMEKKALGESRMVFEGLLSVIQIAAANARVGQGPTVTFGSHNQGQQVGVNSGTISATFGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U339</accession>
    <name>A0AAE0U339_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_463208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U339"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3389228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="721" mass="78734" checksum="3669F982F76A198B" modified="2024-05-29" version="1">MGAAPALRAAGCSACRFSALRLFVGGGSAAPKGLQSSAARSLPTSAAAHARYSTFRATPRLLSGPSIEGRLTEEHADVAEAQEPLNGSDVPWYLEVEPPRHPTLLHEPAPLPEIPEGSPRLMEPLLKFVAEELGFDELTLLDLRAMDPAPAFGSELLMLFGSARSERHLHVSADRLVRWLRGRGIMAKADGLLGRNELKTKLRRKARKAKLLGNSGVARGGDDGISTGWVCINLGTIGRAESEEVIVDESGSTVGFGVPQLGTTLVVQMMTEERRQELDLERLWNGQLKRSLARHAEPAAQVQMPEETDFFETTSTLPSKGRRPKTAGRRSNGRRAGANVAGGSSDTFSSAFAPASKDTIPSGSHFYSTSSRRLNATPIPLNALAELMMTGFRGEESIPEASELLATNGESKAHILGLLRAYLESLPKTDIIKKLTISEDGKTPPFLSVANRVTENIPPAQAWEFRLWLERTARSAGHPDYDMAGVRSLVKDMHTSSSLSRQNYLDLIQVIYTFPVVDQPTVQERAVLALEVVETMFARSEKVIESHVIVPLIESLVQFGGEGAVTARLLSRFEAILTEASMPCPPEHLLIRLLDVYANKANWGRFWDVWRIPSTLGTARSLLMYGCLYQRLAQDGHQLRGTDALRRCVEEMVNEDPPVVPRGRVVEALKACIRVADPEAAAMAEATVPSGLPAPFRPTRQDFMKLFSNLRVSPTEIARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4E8</accession>
    <name>A0AAE0U4E8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Necrosis inducing protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_446724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4E8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042223836" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="262" mass="28549" checksum="C4BFFA0B180A5C2E" modified="2024-05-29" version="1">MYFFAAVALLLGSALTTVSATPVANAERPFSTPSFIGLANDPEAHKFQPVLDFDNDGCYYTSAIDSGGSTNPGLNYAQGVPPNCLRATCRDANRLQNSNVYSRSRCNNGWCAIMYEYYFEKDQVVCGSWGAGHRHDWEHIIVFTQGETVRRVAPSCHNGYGGATNSPRLQGQRAKVVYHKDGGQTHCFRMANAADDSIENYTGQWFLGSLIGWTGWPSTWLRDTAMNANFGAASPKLRGDRFGSALNSAAGGQTGSFNPWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6X5</accession>
    <name>A0AAE0U6X5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_424442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6X5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042052830" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3392694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="392" mass="42391" checksum="1176AC8FD8DFA994" modified="2024-05-29" version="1">MRLLAGIAVAALSGLAVASQDTAEVLVLRAKEDSSTQYDHPRVSKEVARHVLLQRTSRYSYGTDLRDIPNTIDTDTAVDFIATYGKYTAPLFSQPETTDTAQLVIILEGTTAPQRDQLKEVLPKYPRFAINDPPSATANNRLMTLFGNLGIAPSSQCDLASAINPFDTSCWRGPSSAVKYDLHKSPDTLQTLLDNLDRLNKFVAAGDLEAMLVMMPESSRLSKLNNWSDLAAGAGASDLRRRNLETVIVDETITLPTEAAGDAAFGATSRQQEEESFALRPKGRIPHCFNSFNSCIAGTDNCSGHGKCFNKNTQNDTRACFSCLCERTVVNKTTTFWAGGACQKEDISVQFWLITGFTIAIIGAVTFSIGLLYSVGSETLPGVIGAGVSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7T9</accession>
    <name>A0AAE0U7T9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_31762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7T9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62065" checksum="1C5D3E9B757BE42A" modified="2024-05-29" version="1">MSAVPGTRVEGTSGVGRGRCLRATRAFRAGEIIETYPKPLLALPAARASRTTCHYCLRYTSKRGRYASVKLKACTGCDQVMYCGQACQKAHWKTVHRSECTMFQHIKSTVGKEMPTPVRALAQVLVLLKKGDPATVAAFGDNGSLASNIEAFKANEKRWEDIQLQSVGAAMYALPGLTSPTPTAAAAEWAERAMRALCMIHTNSFDRLDPDQGMTGVFLDPRLAMINHSCIPNAFVDFQERTGVLKAQVDIKAGDEIEISYIDFTYPKTLRQECLSMYHFQCRCPRCKDDLDVYEICQMSPAIPLNSISLMPDLDKLRNPAVNRSGVPKGTIDKIYREWLLHKDGIYEVPEEQSLSVWHAVTPLMRACMWAVEPLPMALSAQCTSFVQTGGIYYALPLACFIATECEPYRYVTPFIAWRLKGVMMIVMLMAETARRTASGEMAKVCSHKKLADILASIDQVTICEALLRLIVYQGSVSSSEDSEVLFDAKDRLQDIESLEGREIESALTKKWANDPQDPQGGAFFQNVVLKAVNDLAALATEILELELMYNDHLVRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U852</accession>
    <name>A0AAE0U852_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_444509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U852"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="272" mass="30969" checksum="8AF133AC30096173" modified="2024-05-29" version="1">MSSLRNSVQRRSHRERAQPVERQRLGLLEKKKDYQKRAKDYNKKKAVLKSLREKAADRNEDEFYFGMMSRKGPGSRLSRGKAFTGAVDGDRGNKAMDVDMVRLLKTQDLGYLRTMRNVAAKEVKLLQERFILAGGSEFDDEADDDDDDDMYGSSIKVRNNKQPKPKKIVFCDDIEERNEAVERLEDRLDEEEAGGDADSDNDGGDDKTKEAERKARNLDKLGQSLRNAKKKLRTLSAAEFELEVTQAKMAKTATSGGVTKMGKRIKVKERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8B7</accession>
    <name>A0AAE0U8B7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like f-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_517844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8B7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042025113" description="Cyclin-like f-box protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="36021" checksum="88CA9FF5596D19E4" modified="2024-05-29" version="1">MLTIQNLLLVALTAFTGISDAAPQNRSNRNGKGKATAAANTPQQQAAALPQGVSQATDGSTILDTTARVSGLNLRFKVSGPADQFTTRANVTGGTQDIGATGTLGLNVLLHGDGGQSFFDFPNQAVQGDLMGVVILAPSEQLLWGQHAGQPAGLSRVDGVADAQAVNDLIQKILPQVVAFDPSKVFFSGVSGGALTLSGFFIPAHLQNFAGNGVLLMCGALEPQVAIANASAFIANTKIHFQSTQDELALLQPAIPAAIQAFEDAAAAAGLSAQEIGQLQTVDNTPVGGHCEFDEQGFVSGIQLIADNFANIMQGGDGAVQGIDAATVLTSVVGNEDLQFAGVTKRDTLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8R2</accession>
    <name>A0AAE0U8R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_387983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8R2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="923" mass="102528" checksum="C85592C68442950A" modified="2024-05-29" version="1" fragment="single">MQATIYEEAGIIAEGSIQSARSSQNPQSQDASASIAETEYSLALSVFPERVGQYISAMARLLQSSMPPGPLDDSTLQGLEQELPDMLKTFALKMGHFGSTPEDREIMYFVYKYRDSDGDFDKEEEEGSRPVIGHAQPMTQDDIVSRYLANLDTRIGPELEPSSRDDDVNEEHGVVSHEPESSEMPDIGKYQDCIVKSAAYEWLQRTLSAAANRANAFPDVRKEIRETVIRSLCAARGERTLSRSRPPELYRVTAEMDWDPRSFVAKQEYEENRGDAIARAVTLTGSTQDCQAMTTRQYLSQTWSSSGSQTMQLLQRVLAGEPGDVQSTTWPDRTTVTAWTSGSTFFVTAIGLAPSIAEIIEQVAWLGAALRPSPREQGVCYCTPSVKPLRVRDNPSPTPPEYQCYYQISFEFGGGGRGDHANGQCWHGMFRNPVVVRGYPLARRTATQTGLEMPLNMMACMVRATHVVPFASSWYIKGFSSMLALAELRDDIFLWHHVYDRDGGRVSYFDHKSPNPPLGIITASALQNARHVVGWCSDVKLYAGALSNTNLNISDSGLDRPRATCVLEKVSISGGKFITGGASVAIGVRESPIHLSRDSYLDKMRWVSGQYAILWDEGDDRGWLVNGASALLHLVCAAVEDDLKWMRKCGLQSDQILFKREDVEGSALPHTPGSALNVLVNPRNRELKVVVNDTTYTRFKHLVEKQYRALEQIMDHQFQIEDRSGLDLKCRARKWLEGWDFRDLAVTIKTGPIYARLKTLQTIARGWVDFAREIKAITIFGKGFGEIIRPTNATSMCAHWARVPAGRYYLAACVSDLKAIMRLEDGDGRSKNPIRICNGLHWHVREGLFQPCRCGKASIGRTKVTHSEDVAQVLAPSRMIFGRSPTSASSSVELKDAGAVVFGYSPFLGLIWPDVGSPEEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0JYR3</accession>
    <name>A0AAE0JYR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_529902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0JYR3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3366517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="12147" checksum="13017CA2AA16379A" modified="2024-05-29" version="1">MATLNYGSESTIAIPTAAPVLECLQHLHRADQETRWSTHARVSRDWQGFAEEANFRRLTLRASDALLPSVGAVTTLMVRRQYYRAFSIADALAPLLLSLTSLEGIVYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K091</accession>
    <name>A0AAE0K091_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_455723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K091"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="268" mass="29901" checksum="87605F21B68B80A9" modified="2024-05-29" version="1">MEPSYDTIKFGSPESQIPGSGYVLNFESVGEDLAPQPANDRSIPTLSRAEENFMFFGDSESDAIVLPDSIRTFLNYDSTQLREQAPCTKSDCGELLERTTQQRNEAQMQISSLRNALYAAQQVEKRLRAERDEAREQVAFHIRRRTASRQTEQRLRRERNEARLALLTLSGKEGAYGTGLSLRPHVHTAAQSQMLPLQQQTRARMISPEPAAGDISRGRDVNEWQAKIDVAIPPKGQDGTGLCSPDGYLDFDLGGGYIGNEQQPQELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0E9</accession>
    <name>A0AAE0K0E9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_423791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0E9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3367701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="515" mass="58023" checksum="9662EDE3E11C9B77" modified="2024-05-29" version="1">MPNIYHVTATQVNSFASANPRLLIATGIAVSLITWLVVSNIRQWLRLRHFPGPPIAGFSKWWLLRHELGGNMISDLADVTNKYGSFVRIAPNLVITDDPKFWKQHVLNVRTTYQRSNWYYGMRFDPKRDNILSTRDDALHNQLRSKMAAGYSGREVENLQPKLDQVVLAFMKLLENKYIAANKPFDLATKAQYFTMDAISQIAYGQPFGFLTKDADVYEYIHTLHTNIASVIWGSVYPWIIDVAGSPIFRGLVPSAKDVVGFGKIMGIVKETAAERFGPNKKVQKDMLGSFIAHGLNQTEAESEIILQILAGSDTTATAIRSTMLYAITNPRVVSSIRAELDAAGILTPTDTASDEQIISDAASRALPYMQAVIKEGLRIHPPIAPLMSKVVPPGGDNWNGVHFPAGTEVGYSGFSMMRRRDVFGEDADEFRPERWLDSEPEKIKEMEGTTDLIFGHGRWQCLGRSIAFIELNKVFVELFRRFEFTLVDPSHPWKSDNMGIFRQSDLWIRGYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0H0</accession>
    <name>A0AAE0K0H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_515550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0H0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="285" mass="31437" checksum="7E52B2A640B054AF" modified="2024-05-29" version="1">MVDSQKHNAEQGEQAGQRGNDSMPADSAFQTTKSSKRIRSVMAHAKWNFEKLQLPSIFLFPHLHPSAPPNCLQQHSSLSHTSLSDIISIYAVSHLYQQAMSSYYYPDETGWACFLDERNEPQYLYGDSGNLVPSASSPPQRSDSGKPCSEFSNKSESDSGVSSNTPAHTGWRCWWCRAINYTDHQNIPFLNPRTDVHGNLILDANGQVTCEDYPDIHCVGCNGKCNPLGTPLIDPQWDKNVMDCSVVEGSQAGDERIFPNSCRGSDGQKCSSCTLLQVHASHPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K227</accession>
    <name>A0AAE0K227_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">B0H63DRAFT_441815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K227"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3368571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="352" mass="38394" checksum="1C83C190AFE756B6" modified="2024-05-29" version="1">MDTPPRSGSQRRHMTPSQIAAQASSTSPLAGSPSSKIHISSSETMTLRTRQRNTPYLPTPTEAALLAGYPLLLAFGALFSLLSPETRAAPYDTIRQAHSQDPALSPSYFARKDNLFNVLFVKRGWAWITAAFFAFVFTHPGVALPAQRVRATVRWALVTTWWVFVTQWFFGPAIIDRGFRWSGGKCDTASDALESGTADAGDVFTAAACKAAGGRWAGGHDISGHVFLLVLGSFFLLQEVGWVTVRRARSLVEERSVVMHDGAVKGAGVEVEFKDREMVVKQSVIEGLGYGGRLAAVVIGLSGWMLLMTAIYFHTWFEKLTGLLVALAGLYITYILPRWVPAIRSFVGLPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K241</accession>
    <name>A0AAE0K241_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_489039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K241"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3368724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="131" mass="14137" checksum="93E8BBC1A41D9A68" modified="2024-05-29" version="1">MIQLKTLLNCIDNSGAAIVECVQVVGQKRHASIGDRIVAVVQKQRGAQAAGMAASSAATKVKRGDIRHAIVVRTKYKVQRRDGSVVRFDDNACVLINKAGDPIGTRINGIVGQELRTKKWSKILSMAPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K267</accession>
    <name>A0AAE0K267_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_536249</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3368026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K267"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3368026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="467" mass="51862" checksum="89204273EE342DC3" modified="2024-05-29" version="1">MSSATPIPQPPGVPILGNVFDVDPSNTWWSLKTLAEKYGEIFQIKVLGHTIVFVASAALAEEICDEKRFQKYVGGPVVEIRALVHDSLFTAYDHEESWGIHHRLIAPQLTPEAVNSHFSELLACTDELITKWKTLGAATKIQPLEDLNRLNLEATTLTLFGKKLNGVNGSAEDIRKADAVLKAMEDSTSEAIKRPTRPIKLLNTLVYGSKFKKAISTYRAWAVDIVDYRKKNPTDRKDLLYTLMNQTDPETGAKLTDAQVIDEIDTMPIGSSTAPCAVTCAILFLLQNPQVITKAREEIDTVAGTSPLTAEHIPRLQYVAGIVRETLRLSFAAPGFNIEPIPKKDDKSPVLLAGGKYQIAHNQTMIIVLAGVNRDPAVFDDPLAFRPERMTGEAFERLPAGAKKWFGNGKRECIGKHWAWQFLVVVTARLIRELDFEAVNPSYQFKQDGWFNVRPVGFEVKVKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4T7</accession>
    <name>A0AAE0K4T7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_514296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4T7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3370104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="340" mass="36805" checksum="82FD95DBD7DA6D65" modified="2024-05-29" version="1">MSSRRVLGLVAEHALPQLPPSRNGAALIMTVRLPAVATAQQLCLASTSLPGRIMGVYRESSFSPRCFHTSSSRPRLFKLSSRQQSSPRPQPTPSSSPADATTAPPMSEQVRKLMRHVAHSVVVCTSMSPASGSEPATPRAMTMSSFTSLGLKPTPVVSFNMQTPSRTFDSVERSRRFNIHILADGPSGASVADWFTRGNADGIKLFEKLADECHCEVVAQQQQEYGEEAPILRGPGVLYVLRCRLLTELAESRGLIRMRDHVIVLGEVLEIIEGEQEVAREAEEPQGSSSGLVYANGTYRRLGISITPVKDGAHDHTDGRPIRGAGASPIPHLLKKKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5D9</accession>
    <name>A0AAE0K5D9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_403053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5D9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="877" mass="98487" checksum="0CA150EEDC56158D" modified="2024-05-29" version="1">MDYEWPDFEWLADLSKWQCFTTCELSRPAKSLDFGSDGFTASLTDWHELLQLTRPDATCGLVFLRGRFPDKAGSILSRAQRRDDTGSKGTFGTRLLPPDSDFPSDVELGERKAQGWVNFRWPYTQYELLRKDPVSKVITGTGSCETISFASKGTVYQVNRLKWGYGTSLGENEEGNVATARFRVGGTVRFGCPCSNTNGTLDSDVFTVTESTRSPGPGICCMSAKYQTSLEIGLVENGVPQRVTLYATPDGSTAQPWIDLSSEHRVELSVGEAVYLISTYALRNDTEDDAATEDGSLPKDLLDYLGISRGSVHMTDRLWTALCATNYEAVEAVEFCVVGRCVEQILNITSIPVRQPPRTSPANGPEKLERMPESALIGNIMTGGFVDVQSAFYQIRLLAKIYDFIRTRKFERDFLYQYRSLDEIRGAYLVRLRDAMRSALTWLFVTDLKPGRLLLAVHSEPTEVNAQGEPVNPANAARLGKCALDREQVVSTDGSYNRGCYATMAAWYVTRLCPEAMADQRFVDEIVVPNLPVAYQVGNDRANRNKQPSAKSNVLQWLHFSCILLLCEWLGWEENYHSEDDGLDLQQAAETQERFEKHVSRLKTSQADGWSMEHEELDRVLMLAEEMGLDRLKSLKKSHSWAITRARQTRRLIRDRKRTTKFNTGPTKQWMMARSISNGPWELLCSNHEAYLRVADEANVLPARDRLLEFLLSDYSFMASWDRAEADTQMLGRWWDVEPVAMICSTLLDLKLEGKLQAAAAISPPLSSGDDPLAQSITNARAETMNSDSADNPVRTAGGRPDPAQAELVAALVQQLRLSMDESIRIQLYEMRQMLGQEGDGTGSVKAFEWVTLKPSPAYYPVRLLPKCQPLSRFYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K630</accession>
    <name>A0AAE0K630_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_314881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K630"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3370345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="611" mass="66950" checksum="6C09AB610E4EAADA" modified="2024-05-29" version="1">MADVIKHEETLAPPSLAASVSPSSSHAPPPTPGSAGKNSQTPSPSTPASNSQSSASRRPPRKSTLTQQQKNQKRQRATQDQLTTLEQEFNKNPTPTATVRERIADEINMTERSVQIWFQNRRAKIKMMAKKSLETGEECDSIPESMRQYLALQAMESGKSIGGFFGRAGMMSYGHQGLLGADQGGQGKVLIHHLTCRSLSIGKWTRVGQNTMDLIIFYSPDKCTMTYYINNEQAGYKIEYPFAAIQNIFLNNAESDHLGGITIELLHPPNFYMDSAATSTGFFQVGDFTEEQQASRVMTHHLGGNPKVLSGQLAKLVSLEAFIHRHSPSPMFDQLHHPLSMSAPVSPTARPSSQPNFAQPHVGMFQETQWGIAAHHGMMMRGGPGHKRQRSRSVPGPIDFHTMQMLQNPPSFHITQHENQHHNHNPHLFSPIPQQPNMLGPIGPNLRIDTQAGFGSLDMRNYPMSATTAPSPSDYSSPNFFASQAPDSNSIQAASYTPYSGTFSPLINPSNLGIPPSISPLSFNHQDPAIVGESPPMSMPAICEGSAMSDDGSGLNEMYQNGKHTMTLPLHPHSPFADTNQADLELNQFMDLKHFDVDPASLSPESIHHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K645</accession>
    <name>A0AAE0K645_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_305521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K645"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3370010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="94" mass="11050" checksum="8E82DAEAE1B384C0" modified="2024-05-29" version="1">MKLWRDPIRNFLLVRRRWGRMLLLSLTAPSPDIAKNRFAVVWFLDAALQPQLPLHFSSHHRCRPRPVPLLRQSQCLNPGRFTFSASSSRFAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K898</accession>
    <name>A0AAE0K898_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_483209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="332"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3371901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1692" mass="186042" checksum="01FD97A01BE0F7EA" modified="2024-05-29" version="1">MDAWHVKVVSIDSEVRQISDALRNYINNGDTGTRKVKAPGTKAGRDLLQHLLGRLDQVSTQLGDVRDHSSNLSPPLAHGPDTPLSYSSPVANQHALHALPPDGLPEQHQRPQPDVNADTDAQAGPAASLPITPERSSPSSSSASTASESARLAQGTPQTVDQNLQHGHNHHAHPPLLNTQTAPPATSPEQIAASTAPEASPPVKAPPQNTQTAIQKAASPTSTVSRRVTESKDTSPLFDCTYLDIHLLNEDFFESCSRHPVVRDRGYFKLQVNQLPPVHVQKVSRPSRDHATSFMYKADRQGLIKVDSGKRPRFSSPRLPLPSSAKLNWSIEEQRDLWNSTAQDPPKGTMPYIIGNPLFEDVELSPGEKLKQRGRTILEGINTQYVYFNLKGKTITTMHREDAHVRSENLLRSGENKFWCFVKPAHAKLLEQKMKVAYREMRGCSQAVRHLSRHIPPARLDEWGVEYTLDYCIPGQAIVTEPGTYHQVLNLGPNYALAVNLEYLSSPDDPPNYTFCDDDCPDKFSISAEDFRIYRKPGERIEDELLDAADPASSHLTQTEEQSVANQRVGKSMHKVGKSMHKVGKSMHKVGKSMHKTAQNPIEEPDLEPSDRAASEDQVLKPLRVSIEHTEKSVLEKVSEPVSEPVLEPVLEPVAKPITEPVAEPAILPLGHAAVSVPEPIVEAVLEPIPVPELLMFSSEHAALSPAGEPQLSHFELAAPIQILPSPSCHGNTEQPESPRFSPSATDISATDNQGLVSQPARFAPVSSSPCLDSSNEELVVPQTRAAISPSEESVPPPMPSPTATSEAVLQYHSPEKLQRTSEHSKLPGLPPTPPATSPHERNLLERVVPAGTVAQLPSSLQPRLSPHSLSSLQPPIPPRPQSRDVHLVGPEVRPNPVGSHSSSQHLLCRFEPRPINDYPPQSPLPPLSAQPSHPWSAHHQPSSALQQFNSTYSSMVTAPPQAEVNPFSLPRRPSNHMELDAGFRGATPNMNARKPATPQPKRRAEKQPATKPAKKQKVVKALALALTAALAPASAQAPALTQASSPTPILAPASAPAPAPAPAPSPARKPRNVSATVRSPQRRLLPRPFEPNGHFPGTYRSNSSPHENPESCLASGHPGQVYSGPQPPPVEVLSTQRPPIYITYELAAPRIEKLGLIGGFASPHRPPIITQYEPSAPQVENPGPLMAPLHSPLTPEVGSPALHRPLTAPDVEPLTPEAESPSAQRLLSMPPVQPTPSQDELSSNQPRLNGVVSSMVSTPSRAAFLSVQEPAYVAGLEGLASRALDRSWIDSITVTPEQISSRSAFDVFADLVRQWRANPMLRPTPYGPGGGFEFVKHAEALPCESDKRFRTADDRLDLTSFLQRFSRMKLARWYENAVRLRGNFPASRDITDELLGILHWDVKWRTHLQDILREGSCWRAICRNTEALLPLLPPAPKYSSFGLLKDKVAHLHSRLGTEIVGKMFDMVNIFMESIWDDKELNDFIWEGACIEGLSLEQLIPLMGPFHLIESNIFNLDYFWPRPASWRSEWPMDPTLVAPEDNTDCDMCSERSCDCFAKHILPVPRIMEDGRRGPGVRAVGTHYMGSLLGELVGELAPIGTHREPWQWTIEFRRPDMGNEVVAEIYPLEKGNWVRKVNHNTNPSADFKMLKISGRWRQMLVAGRDIYDGEEITARFGRGHMRAQPYHVVEGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9L2</accession>
    <name>A0AAE0K9L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_526837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9L2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3371975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="187" mass="21738" checksum="B703F0690828E910" modified="2024-05-29" version="1">MAGYFFDGEVPEKPCRTCASEIHRGPASLCVSNTGPGRNAREFLDNSCTNYYYSAGSKSCSAREYMENPRPSPWGRGDHPEPEDMPPDDIWYNITHASEEELDLWGSHFIWKSWACLEHSSNRLSHRFSNGRHLRHRYPRVYRYAEVQTFELAYITFKAPNLHNFAISSERWEEDTADRLETLADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KAL1</accession>
    <name>A0AAE0KAL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_485517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KAL1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="229" mass="25392" checksum="9B7EE7A8F96A0E70" modified="2024-05-29" version="1">MPLQLRQATEADAPACGRIATAAFVDTLSPTLFPPHLNPGPDDEVTWRTQRTARRIREGVPTLVVVETDPDSGKEIAVAGFAQWQKPYPPAGSEEEEKEEVLDAAAKAKKEAEKDPGPPSLDVTVFELAVQIMDEETEKAFGERGYKDMWYLMMLAVDPQFNRRGVGKMLLRWGVDQATADKKDVFLVATPAGRFLYLSAGFKDIWHRTLINVPHTGMLWELPGKEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDU4</accession>
    <name>A0AAE0KDU4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_481603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDU4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3375023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="653" mass="73525" checksum="0A1AD67A90373138" modified="2024-05-29" version="1">MVFMAKDLRTDQTVAVKCLTKRAAASNDSFYDFAIDDKSEELVLHRRLGSHPHIVNLLDSYETDNHVYLILEFCPRGDLYEAIRIGHGPLETEHVRRFMLELVDAVAYMHSKGIYHRDIKPENVFLTQSGSMKLGDFGLATTEQWTYETTVGSDRYMSPEQYDSAGAGYSPAQADIWAIGVCLLNILFSRNPFSTPTEADPLFLDFSRDKQSLFDVFPSMSQDTYEVIVQCMNLDPRKRSLSGAREALLRVVSFTTLDEALDDFCSAERRVIASSNREPLRTPSVQSPQVDAGAFPWAKALQSSPHKPIRQLSVIADDEYYSEDLFSKSGATADWMSGSAQTPSMSSMHDSSLGASMQSFNISSRPKPIRTNARITPMAGSLPIHMTKNRNQSSMSMIFGRKDAVSKSWSDLWDEEIEEEEQARQLETLKEMNSRTWSQESKTTPLPAAVDDDYTPRLGLSPAPKSATLHVEHDIPSIDMTLESHMDDDLATDGLFFYEPPTVKEQPATVREEVHTHQHGSLSSKRGDMDKWLVLGERRRACTGSTPSKAPKAALRDIGFESSLDNGHGVFDFYGTTLPNTYLVSGTQHHPQTHITTPTKWANAHTPTKERAKECPRSKGRDRDWNWNFDWRKEKRNAIGGVEWDGAWQETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KEN4</accession>
    <name>A0AAE0KEN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_482620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KEN4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="781" mass="83428" checksum="42B399FEE441A0B4" modified="2024-05-29" version="1">MMDTATLQTPKSGRSRFSKALPTPPGGSSYLSFATRGSSFPHQQEQQLPQLPQLPPQLPQLQLQSQLPPLPPSASTPTTAVTRKQLPPIQTGPPLPPPKELEREIEESKQRVRDREREWEVTMALASPLNSPLPPLPLTSSARTAGLPPMAIPRRPVGGGGSASVVASPPSYSALPLVSVVSPAPPVLPSVSPQSELSPVGSLSSLLSAYSNHTSESTPRSSTNSANDINAKASYTTAPSGQPVRLDGPAATLPALPFEHNAQNQEYSTGGPWTSGAGDRELPPPPPLKDIQRRPTPPVLETSHQSQVGQSPTAGHTAYSPASYSPQQPGQLWRRRSQRSDKSLAVPELKLVSTNGSTAESTQNPSQSGLGNLDSQSQPRSLDQLASSRPAAKARVPLPRSSNANLPGRNIRPVASRQQIVSEEEKEENAETMGQKASKLDKGTKESSKHDETQTVPTYDGASQAPHKPLPIPTPSLPRLPTPEYETSDFKHPVLETIVSPLSPASSPELGVEAKSAEHQVRHVPSSSSLVPKRVPVGLPSSPAVNRDRAAKPRGQFSARSSSRPGDTSPAAIRRDLAGPGNMQGPNQREQPSLPQGIRAVSENGSTASVETLKPKPHLGNGNTSAPRVLPTGESATDETELTDHPGAALFPRNWYKPLPSDVVMDAQPLSDKNLRCLTNHRYMTSNRQRYNPIACRTCGHKDRNAECFICSACHLNVCVSCNHGLRMSKGDLKRLVHQIEEKKRTAAEKDGTAIKGRPDSDTVTPKAAEELALAIASDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KF72</accession>
    <name>A0AAE0KF72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_526177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KF72"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3374881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="119" mass="12968" checksum="A2370B0EE2BBE057" modified="2024-05-29" version="1">MPSTTAPQDPNSVLPSGEFQANPTLKYTWAFVLRTKYTLSELDNIAAGRAVQYPEQIPAYQPTSNGAPQPAKARELMREVFSRSQMADLMAMMGLAPVEFGDQIKNGSKAVMTAFGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KFJ6</accession>
    <name>A0AAE0KFJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_481647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KFJ6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001401">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016441">
        <property type="entry name" value="Tti1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005250">
        <property type="entry name" value="UCP005250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="834"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3375046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1186" mass="128084" checksum="0FC3CCC01EE69F6F" modified="2024-05-29" version="1">MAAVAPSAQRTAFFQQLKPLCVPLSQLAIRSTDKAADAHEIRSLLESISRIWTAQVSRDASILDDRLADYVFFPVSHIVRSQAQYPVRVIEATIRLLGVLIQHGWKAKIPRQLSQQLLVFLAFIIGGDPAGQDKKREIPEETALESYRTLAALVAAVELSPLASPSPSPPPSSAEDGQTIPALGHSVTVMLDGVTGGTTPAIQLEALNCVRIVFTAVKDNSVLAQFLPGTVSAVSKVLSLPLQRRTQNRVLVACLEALKLILINVLGDLKVRTLLKQREVLRELEPLGTLKEPEGTGTTEQYLASQEAPGDKDAKYRVAMTPAWLKATSSQVKIALSSVLRLRNHDSEDVQSALGRLCISLLDECHSSLSECQSILVETAMMLEDESTKSTLETSLQDLAGVFPELGDSIKLGLYNWITGLPRVMQSSDERVKQLAIRNILRGIKLAAALQMDSSTLNDSLGDALRDSIAALIRNSKPSRMLDDVGAIGDSIMLANANMVVGPHTELTELYRPVLFDLESQKTTRDEINTLIANIGSAEQQTKLATAMLGYLRDSDGVDQIASYWLVFELLKSTYGCSSDVDDMMDLSSLDETKYQDAAFQELYEFSASVLSSHSDSLDETDWRLEATALEVTAFAASRMKSDFRPELIDVLYPITTFLGSQVPQLRRHAITTLNMMAASCGYESVPELIVDNADYMVNSVSLRLNTFDISPSSIKVLTMMVRLTGPKLIPFLDDVVAAIFAALDNFHGYPAFVESLFSVLSEVVTQGVKSDMLLLEDSTTKPVDHRKRKPESDGIPGILETLEKRAKRARIAMDEESEAREINGHPKEPWGPEKSQAKSILDSLEPGQDGVDSEDNGDQSSSAVEKPKQPNTATYNLLTRVLSLTQHYLTSPTPTLRKSLLDLVATVSPALAPDENAFLPLVNAVWPVVISRLHDSEPFVAIAASKALAALCGAAGDFLATRFKTEWDNGLGKWFAKTRAEALKARGAAKAATRKGGPASHHTNNISLLGPSPGPLGVSSDIIIPGLTTGASTGSRDTTSASTKQLFSQSSMMTADSSSIYSTPTTTTTTTSGVVGLGRFSQASQVWEAAVGLLGAIVTYVRIDDNMFDEILDLVADDVLALPQHAAVREALDAVNADAVWLALYARGAVASVPSPMVDGFEFVQMERRVGGVIKSAAVVGVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJK1</accession>
    <name>A0AAE0KJK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_502417</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJK1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3377874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="356" mass="38368" checksum="08D1F25A52863DAA" modified="2024-05-29" version="1">MATESFIIKTPCSSANIGPGFDVIGLALSMYLELHVTIDRSKTASQHPLNCRITYEGEGEDSGDISLDPEVNLITRVALYVLRCHDQRAFPAETHVHIKNPIPLGRGLGSSGAAVVAGVLLGKECGGLHHLTPERLFDYCLMIERHPDNVGAALFGGFVGTYLKPLTPEDVARKEIPLSEVLPAPAGGIDTGVKPPGPPHGIGHHIKFHWAPEIKAVAIIPEFEVATAKAREVLPSHYPRPDVTFNLQRIALLPVALGQSPPDPELIYLAMQDKLHQPYRQTLIPGLTEIVESMTPATQPGLLGVCLSGAGPTILALATSNFEEIADKIISKFKEQDIACNWKLLQPADGTQVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK31</accession>
    <name>A0AAE0KK31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_222488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KK31"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="100"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="435" mass="46834" checksum="8A379C74CC19C506" modified="2024-05-29" version="1">MVEQRPVHNSEVYLLRQTPYQNVPPLSPPSPITPAEDDYCTPIEPLSLSQPAIAACDEKLALEERLVSAVHVLHTETTALQRITQLYSSDRVARDGFNRAVEAITRRQGDQGKNGKVVVVGVGKSGHIAKKLVATFNSLAIQAVFLHPTEALHGDLGQIGRNDTLLLITFSGKTQELLLLLPHLDKTLPLILLTSHTRPETCELIRLRPDTILLPAPIHEAETVSFGVSAPTTSTTVALTVGDALAIVASQELHSTTGVASVFARNHPGGAIGAALRRPREDVVRNLVVPLDAIGHLDSNSPITGADVLRAGYASPSGWVRLSNGAVIAPPRIRCLAAADLARHVCDDLTWLVTPQTAFVPMAADATVRHAAEWLRELMRRRQQNLPPSASEVLAQESERDADQDGSIVAVMEKGICIGLVEAAKVLHQEAESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKC9</accession>
    <name>A0AAE0KKC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_236952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="194"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="844" mass="91201" checksum="554A7F5B345C9E68" modified="2024-05-29" version="1">MEIVIPPRDHGPSTFRYTWDENGEVSQITRVVDDSSSSIAAAIPPNIARGRQTVQWPFQSIVTETDLSSPSISTFLPTRVATWQPKPTRDYEYDTDSIATEKDIIPDYVVNYLRGETPETVAQRRLNGGKLGHRGPVDLERQEGAHQSRVADFEGFYFDSTSRLGSGEEERQILPSSRRGSGSSNRWGQFTVGWRAGLALNVLLWFLILVAGFVCFILAISRVSLFAGRSVIFAGSCAMASSINWGLHAALSAFGVVLVAGANYVFQVLSSPTRNELDVAHEKRKWLDLGIPSLRNLRHVEGTRTMLAIIILLSAVFTQTVYNAVIFNTQAAPDFKLVLATEAFLKGAPFSNGTSNNRGMLSRFDLLTLQQQAIRGDLVNISTPECFRTFEGAFETDFKAALLITNLDSQSTSLLQTSSKASPALASVITTESIADLTLDQFSVQYCLAQPVGDASQTTCEVDLNGSLLGAVALLNLITVVSVAMVLLFIHTPSSFQPLATLGDAIASFLRCPDPTTQGACLLSETDVWQGRWGSAVPKYWIPDGDHYWFRTPSLSRWLFASISWCVCVGLTVAALVISVMREPSSSLSPFGIASPHNSLILVPSLSMSAAAILASLPHLGLAVLYFSLNGIMTAYYLSHESSLFATTNKPARPLRVSADPEGAQTASLYLTLPRPASWFLIVAFISLSFVLSQSFFAVTIQLVDMPISQPTAVTPNFVPPPTATVIALSFSGVGLLILLALLVVLAVIVVGLGFRRAPPAGLVNGQLVGNPMALPDGSCSAVISSRCHGNGTSNAREAHRERLWAKELVWGVIREGEGMDVSHCGFATEEKRIGVVGVARCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKD7</accession>
    <name>A0AAE0KKD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_226944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKD7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF122">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3377827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="424" mass="46431" checksum="69C3CE44EF2DE95B" modified="2024-05-29" version="1">MATAALMSPSGPYHSHHSSFSGYPHSAPATSIPGMISPVDSRRTSDGSETNHRQSLPSISEIISGTKSYAPPVQAPMSSSQGLPSPFASSAPSRPYGDVVADTNPSPRTLHPTTGYPRTDTLTAFSDPARPAIASRPIPAPLNTFTGQHPSPPVKMEQADAENRRLDVSPYSAGHHHPSSQPNSAHYSQSGRLPPGQLPLGYPISPQQSRSAPALPSPFETRTPVYGDEAELARGNEHKPSMDESNETWGHDRGYEELMQSISSTARTLVAFSDGYTAAAREQHGSQPILSRLPTDNELDIFINNSLLITRKLEKIRQVVRQQNRLNTERTRENGGRKVIDDDDVPMYEGLKNPYGSDGKKRRGRAAPPGRCHSCNRVDTPEWRRGPDGARTLCNACGLHYAKLERKRQLDQRSLRAKQMDDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKP3</accession>
    <name>A0AAE0KKP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_479388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKP3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="154" mass="17519" checksum="AFA8516E7971365C" modified="2024-05-29" version="1">MPNAWAKALFSGTSLTAYLGGLAFLSRFCFGCVNGTLLIWVKDQRRHFSLWDKRAFVGDRSKLGGQGYCTTPQKSHFKRETERRMRLFGERKWILDRGLLEFSIMTNSQHTAHLAPAPLAEASRLYQQIACLMMWRPDLLDCALSALSTRICEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKX0</accession>
    <name>A0AAE0KKX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_547797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKX0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3378097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="758" mass="86157" checksum="001369EA4179BF60" modified="2024-05-29" version="1">MWKKYLESGYAAMEKRTFIESNRVSRGGVRRILKTASTSALSLFLSLLASAGLLLKAHGRRVLARPKTFFPVIFFLILFCIVLQKRDGYHVGPFGSHPKPEVPSGPPPVPGEHREEKLLRQLKDKFDIEKNALEKAPGAMAIYGNTLDTLAEKENRLRAQEDNLTPTNNVTSYSTDAPFIFNPYPKYNSPSWKQQHAEYVPCMGPTGAPVEDILVFKGRPKAFPEPGFGTYDDLGIDQNLCYERETRLGQYGVTPVTKKDGSTLDWDNVDWGKLQRECREKNQARFATSGPPNNFIDPDDVKADLKYEKFEPSGKMKIPKRHAAHVRRQHVPGVGPAVTNTSMVASEPRTALLLRSYTGKEYTDNDKQAIRSLITELSLRTGGEYEVFLFVHVRDESDIWSSDEAYEKIVQSTAPKEFWNITILWNQQSIDKLYTKLPDKARRVHNGQFLPVQIFMQQHRQFDYVWNWEMDSRVMGHHYDVINKLGEFAKKQPRKGLWERNERFYVPSFYGDFNTRFRATVERLTAGSSIWGAPDIPVVKPMGPKPPVPSPDQDRYEWGVGEEADLITLAPMFNVINSGWVMRNQVWGYRNDNFPWGKLPRRATIITQVRVSRKLLDIMHAEDLRGNHVASEMVTQTTALLHGLKAVYAPMPVFFDRPWDGAQLARWFNGGPKSASGGFGSAMGWGQEARFQGSSWYYRALPPQRLYNNWMGYEDTGIGGAGWEKNNGRPCLPAMILHPIKEVKPTEPGTSSISNLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKZ9</accession>
    <name>A0AAE0KKZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitogen activated protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_496020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KKZ9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="519" mass="56797" checksum="7DCD5EB89C59D6B8" modified="2024-05-29" version="1">MADGFAPRSMKRKNVKGLALTPAAPKPPPTAENANNFGSSQGGKGDDNAAQLEIGIEFNLDLRPEDLEIIKDLGAGNGGTVSKVRHIPTNTVMARKIIHVEARRDMRKRIVRELQIMHGCHSDYIVTFYGAFLNDNNDVIMCMEYMDVGSLDRVSRVFGPIRVDVLGKIAEATLGGLTYLYSKHHIMHRDIKPSNILVNSRGSIKLCDFGVSGELINSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLSIMELAIGKFPFAASEQLSDAESAPAGILDLLQQIVHEPAPRLPKSDAFPQILDDMIQKCLYKTPEQRPTPQELFDRDPFVQAAKRTPVDLREWACGLMDRDNRKSHLAPQLSPATQELLRSSDSPTFLTTTDSTMQQTPTSGEIPILGTMVSPRDQYGSVSNRSPTRSGPGSLGRPSGSTVHPGLGSRVVTTNSIPRLGQQAPAEERFSGSSGSQSASRAVFALPMRPNVPTGPLPPPPPRRQPTLEDPRREIRRQAPTGLPLERTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N0M6</accession>
    <name>A0AAE0N0M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator Blm10 middle HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N0M6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="146" mass="16241" checksum="D87EDBEE8ED13F0E" modified="2024-05-29" version="1">MPLPAAVLQDPDACLAIFVPELIDIETQTRGPKIIISWYTQLLSRCLRLDGESNILYLRQPALDLVQTIEDSSILRALTVSARWTAQLLTSLNTTYAARYNVVSVDHGFDGSPSTGCWGWDRVNTKIIWHVLSSKALSAAYDVFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N2C6</accession>
    <name>A0AAE0N2C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_489621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N2C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="264"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3367680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="851" mass="97075" checksum="6C9D54841A2DCE41" modified="2024-05-29" version="1">MANAREWAAEQDIANISVLAITNIVLAAIHAAGTRTFMYLLSHAASWYYQSPREWIVDLYIRMAVISHIKFFLDLETTKEWWRRFWALISRDRPPEGLPGQEIADVITKGLIIVIYIVFSYMFHRLDAVVIFLYGYGIWIVTLAAVLFAAFSLSSKMVGWWNGEPQAVPSPFPFLRMLARIGLALYNTPFLVVEILRTLRGRASKMFRSSFERWHIRRPMLLYDYKPLEKEKGEIRLIHLGRKWPGCEISCSLVAVPFDKAPPYEAISYTWGSSIQDHIVFFDGRWLPTTKNVHRILNDRASYSQARWIWIDAVCINQKDLEEKKTQVDMMGAIYRTAERVIVWLDDKELTHTQVTEATYLLEVINFNSVDPSANEHNYAKEIVGHRSHWQSLNSLLKHDYWTRAWIVQEVALAKEIHIVCSRKYIGWTHLVRMMLPLLIYPGNVVVATATREYDLADSHIVKGASRILFIAAIRGSFHDAETRQSLSDCLQKTYNCAATDPRDRIFSLMHLVKWPSDGAPEIQVDYKMAVADVFTNAARYLLLKDLRYVLMAAGIGHQRLTKSLPTWVPDFAGSTFLYMFEHTIDPDLRYRAGGVMKDNATGISLKHGGSGPSSATQLTAEIIIVSEVSHITSSIMVIDPLSGTAGPSIHAMADEMREFFREARNLAVQTLPFRYPGNKTQTTQEALWRTLIEDRQITDNELEETKYKRPASQELELCFLACLELYMSPPDAHAEDIHIARHPELRAMQTASSKFAATYRYTRLFGRTCRGRRFALMASGLMGLAPPRTKVGDVLCVMPGFEMPLLLRRCQNNQNEYEFVGVCYVHGIMDGEASSKTNGSSENAREVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N380</accession>
    <name>A0AAE0N380_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_489753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N380"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3367769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="479" mass="51304" checksum="D3B6C935F6AC0BA4" modified="2024-05-29" version="1">MSARNVDDDDEPSYIDYETFLDPNFSPSSFANTLVLATNNPNDAPLDLSTPLSRVLFDIQEIDSHIDILTTRSAIPLLTHTKEQTDASARIVADIDTQIRALNDSYKQLEKEVIQKHAEADEVRHVASRLWETLRLGRAVGRCLQLGRQLEVQHSELAGPSSSSTGPAAAAAASRNKEDHRALVRCTHTLLSLREMFSSALTPGAEGFGIEKVVAVRSLRDTIVTPTERSVRETAERIIREFSVGTAAGSATFAQSEETKARTISALTTLYLLSPTNLAKGEKWAPTLMLQALEVYLRSALQSSIAGLSRALATLPSLDRALAEVSARCQNVVALEAVLEATKAPTHPLLQSSTPFQAGVKPSVVGAVSEKGNMLQPLLAYLETGSLASYFWRTMASSMASRVQEIVAKGGVSGRTLRTNRQGVADAIRDCVIKGSQLPSTVAAGAKSKGKGAADGESAGGWEREVAVMVGSVVNNIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N534</accession>
    <name>A0AAE0N534_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_514614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N534"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="143" mass="14985" checksum="C9980942F54F273F" modified="2024-05-29" version="1">MSPSSDHKPLRQLAAEKLHGEGANPSQLGDPISLKAETSDYDARGEGADGQSSSPDEMPIPVRTPPESSDGSHEEKKLRGGHHVRGMLTDEIRQGNAPKPKKTLEGDATSMKAETVDRDPVDHENGSNGNGGGGAGRARGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N650</accession>
    <name>A0AAE0N650_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_550551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N650"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041926220" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="18065" checksum="C60E0907C9DF4F03" modified="2024-05-29" version="1">MYPRSPLFVTAVLALSSVVSAAIGTICRNQDPYISCTVAIVQAVTPPCEANPDKAAATSCLCSTLSLHKSCYERLCTTSDTFIDIFNTMFNSKTCPNAPPLKTPVYTTAVPTNAAGGGGGGGGGGGNPATTTPPATGAGQGSTGAAGAASTTTSKGGAAPQGSGGDMMLLSVAGVVGGAALFGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N724</accession>
    <name>A0AAE0N724_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_485094</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N724"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="231"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3372523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="516" mass="58225" checksum="08B5D2BA450A9FAE" modified="2024-05-29" version="1">MATTDGVPQDLSIQTLHALDKASGPILSAEAFPKSTFTEIKAALDRLASREMVTYETQERDEYLLEPEGEQIATNGSHEARVFEALRQAVEGLTVQEIEKAIGDKTVSKLGQSKAFKEKWISRTKDGKFKAATDSIKDVTLEQVQTVKATRTHPDPKILAELKKRKLVRVQKIISFKISKGPKFALEIAKEETDLTADMIASGAWKTATFKPYNFKALGADQNSGALHPLNKVRSEFRQIFFEMGFEEMPTNKFVESGFWNFDALFVPQQHPARDLQDTFYISDPLIAGKPGESSSGEEKKSYEEYWENVRQVHENGKFGSIGYRYPWAAEESLRLVLRTHTTSISTAMLHKLASKKGPDGRPPPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYNLTLGGLMEFMDIFFGKMGITDLRYKPAYNPYTEPSLEIFSYHKGLGKLVEIGNSGMFRPEMLQSMGLPADMRVYGWGLSLERPTMIKYGISNIRELLGHKVDLNFIQRNPAVRLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8M9</accession>
    <name>A0AAE0N8M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_549154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8M9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3374846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57443" checksum="9142820DD70698DB" modified="2024-05-29" version="1">MSSDTSSPVNQDPRFGVGRTVAVIGAGISGVCAAAHLLKHGLQVTVFERSSFAGGVWHFDELVPNDPPYPNNLPSSGDYNVSKPGEFAYSTPPPEPHDDGGDGGALSSATGSKDIVELEVSFSPPGPAYAGLKNNIPTNILVSSLGPWPEGTEPIVGQSVVEEYIQTLARNNGVDNITHFHARVEEARKTPTGVWEIRSVSLEKGESGPRLVERLSYFDLLVVASGHYGMPRVPDIPGLKEWKSAFPSRVSHSKQYRRPNKYQGRNLLVVGAGVSSLDICKELSSFANKIYQSVRGGTYDTPASMLPPNALRVGPPARFDLQEKRREGQQTLGSVVLADGQVLDDITDVILATGYVTSYPFLPQFHSDTASITEAGESLIVTSGGDMAHNLHRDIFYINDPTLAFVGVPYYVSTFSLFDYQSQALARAFAGKARLPSREEMRAEYEDRVKQKGLGRTFHALNQPGHEYQYVKNLVDWVNEDGDKLGETPMYVPTEGWISDFDEFKAKIFKARAAGTSAPEADSTVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9N1</accession>
    <name>A0AAE0N9N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_480491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9N1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24187" checksum="379CAA8251257CC8" modified="2024-05-29" version="1">MPSGLGLDHNAIITLRPPSALNDNEWLPPTLNWLDGRWHITHSTLPHRTTQRNTRIELTISAAANGKQSFHIESSHQALEASKPKTESVSSPSQTPLDFSASKGTASRFGSWQILAWGKEGQLDDWMIEDGDGWISDSSGERRADWRNSYVVVHVEGDGEDEKEKGDGPGIEVWSRRGWWKPLYPETVGKIKDALKGAGLEYLAEKLVGVALDDTRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBE0</accession>
    <name>A0AAE0NBE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_546907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBE0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3377486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="362" mass="39533" checksum="7553E61E6E9FED1C" modified="2024-05-29" version="1">MGAISELNLPVGVLYGDDVLKLFQHARKNGYAIPACNVTSSSTVVAALEAARDQKAPIILQTSQGGAAYFAGKGIKDSAEKREASVAGAVAAAHYIRAIAPIYGVPVVLHTDHCAKKLLPWFDGMLDADEEEFKKSGKPLFSSHMLDLSEESIEENIETCVNYFKRMAPMKQWLEMEIGITGGEEDGVDNSEVDNASLYTQPEDIWQIEQALSPISPYFSIAAGFGNVHGVYAPGNVKLHPELLGKHQAFVAEKLGSKEDKPVFFVFHGGSGSTKKEYTDAISHGVVKVNVDTDLQYAYLTGIRDYVTSNIDYLKTQVGNPDGPNKPNKKKYDPRVWVREGEKTMKARVEEALKDFNASGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCL2</accession>
    <name>A0AAE0NCL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ef-hand superfamily Ca2+-modulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_248236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCL2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3378463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="198" mass="21090" checksum="7CE01D1B207CC247" modified="2024-05-29" version="1">MPAKRRPAAESAGASTSGAAAPPKARQSKLAKENNITAQEEAEIKEAFGLFAEAMAGEKEGVIQIGDVRRAMIALGIPPRDKAEMVQFTAVLDPEDEGFATYPAFVAVCALKLHGQERTSEAHARELDEAFALFAGAANAPAIMMADLKRVAAILREDDISDDLLRDMILEANGGAGVGRGVKKDEFDGVLRRAGVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NFY5</accession>
    <name>A0AAE0NFY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_474376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NFY5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="188" mass="20356" checksum="2926547BC29C4E95" modified="2024-05-29" version="1">MGNIRRESTYGSGGGPPPVIGGRESWTTPSSPPPASEMEHRAATRSPGLQEMDEGRSTNRGSELDGATGTQAWSVSNTNRGSELEGSVGWTPPPPAAQQQQQGYFPPPAPPPHQQQDYPSGYPQGPPQGGYQQGPPQGYHQQPHDGWHPQQQLQQQPMQQIYDADGPYPTGLQHPPRAYQGPPDNAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGH9</accession>
    <name>A0AAE0NGH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_196098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGH9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="645" mass="71546" checksum="5A4777AC5CC0A440" modified="2024-05-29" version="1">MGAYISIDTCARQYGTNPNCSITFFDIGRTNATSLGGATPGNFEPDADIAGIGVLGAFLAVTLFSLLMSIGSTLWWCSKNILHFKSMVKRDEKSVKKKWQISIAGILETLILTCSDQQIFTGGAYAITLRYFKGCTISAYHYNIVANMLLVTCATHLMAVTVSRHYWEHVYVGFLRVAVTALVYLVTGVLLSNQGGGNAFPTEVPPASAQYSEILMPAACFQNAKFSFGDNFKGSFASSNDFFRARIPGWTQFLVMFIFYALAVLINLGRLIRRGTGHNGKRRKFVNWLKTYFAILFRAKRLLYILFSFYLFAGIGIASWTVATSAMYVLELRSWVDKSIWMDKNNGKNPENDPATFGQLVPVLLITLVIFTFLQILSERMHARKKYHKNRGNESPSGQRSPNNTVVKFNPKGSSDSPPESRWIDKSVIGVAISDPEELDRIAAIDAGATAAHARSQSRGSDARGRSTTPLSRPPPVTTTSLTSTAKPPPMYTVFPSPTMNQSPMGSPNIGSSSSDMPPPVPKKSRSREFSRSRSGSISPPDPPRPLPQKELRPSRSRDFILNGGANQQQQQQQQHDRMPSYSREAPSPSMQQHELRPSRSRDVTSPTYFSQQQHELRPSRSRDFRRNGVASPSLDQIQFADGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGL1</accession>
    <name>A0AAE0NGL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_545606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGL1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="94"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="631" mass="66231" checksum="5BDE294BF8F2EA5A" modified="2024-05-29" version="1">MAKRHSLGIYSVHEDDSAVVEMRNSPTESTESAILPPSGLVMPESKSPPTLETSSPTSQSGSAETVVPASLPDSPNNKSPDAPRYITGFRLAGLVTAMTVAVFLIYLDNSIISTATPVITADLHETADIGWYAGAYTLVSGTLQPLAGKFYTFFRKKFVFLAFLFVFLVGSLICALAKTSPMLIAGRAVAGAGSSGLMNGAWTIVGSSVPLQKQPVYTGTMMGVGQMALIVGPLVGGALTQYASWRWCFYINLPIGACVAVLVVFITIPSDAATTKKGAGQRQDGATALSLGRKIRKLVSSLDLGGFALLAPAMAMFLAALQFGSDTTRYTWGSPLIIGLFSGAGAAAVLFVIWEWNIGDSTALIPGSVVRRREVWSSCGHIFSMAFVVFIANYFLPVWFQAVKGVGPTLSGLYLLPGILGQLSFVLLSGAAVSKLGYFMPWCLFGGVMISVGAGLTTMFGPDTTTAQWVGYQLIQGIGRGAAMTMSITAIQSGGLGGDVVAITMSLLIFCQNLAGSLAVVIATTIFTQSLLKDLPVLAPSVSPEAVISAGTGAAAVRGLLPEESPELDGLLRAYSYAFDKTFYVVTAFAVVSIPLSLFMGWNVDVRKGRAKASNADEEKTAGENEAVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NH50</accession>
    <name>A0AAE0NH50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_204665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NH50"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="159" mass="17502" checksum="3615173540D19E34" modified="2024-05-29" version="1">MLSFYEQMQHGYQCFPWVDVALGSRQHPREQGLLREYVTLTPSITGHCSVSTLLFPFKLQLHAFVSGDPIATSNSPAKCRIAAIISVLLLCWLALARCQSRITWLVAAAEGLLIGLAAPGVIPRLDIGGCEPEGLQCGERWDDVDRQGTRPAHWTLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2024-10-02" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHD9</accession>
    <name>A0AAE0NHD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gryzun, putative trafficking through golgi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_208618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="336"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="632"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1300" mass="144594" checksum="217B6832583AEA6F" modified="2024-05-29" version="1">MDEYPTGSLDQNIPLLLTLGTSARSTYDPKLSPALKDQAILIRSELPALDTVQAHALLSYVENRDASFLPANGRDGARRYRFRVKTAERSFLLPPRRARLPDGIEASPLPAVLHSPYSPLSPVSPLYPDGLMDTQWILKHQDFIPSVLLCFYDLVSEPSLATLCDNKIKTDVNNLRGLLSQSGYRTRLAVVLLSDQALPSVDGVQERLENIRRVCGLDPKALFLVPPNESQEELERMAENMLTTLYGVAVEYFRDLGRHSRKKRGRNMAPQPTVPPTSGTSQTLSLAGWNVRYDFKSAMFAEYRLEMDNALRSFEQAYENLLGVELFETIPSWSPRWNDARFLADVIAVRCLRCLLWNGQHSAAARRWQAHRDRVAEFVDRRGRGTNNYGWEAWEARWATVMANLIEKAEISDFAPSTLRIYLQPEKNVMGERLQPWELLHHPGYWYHLAAKHLCARRDLAHAMSEDDRMPPSFSPASHVASTAFTYDTYMCPQPHEEYPINSVQGVDHSHKIIECLMRARSEFLKRQQLRFAAELSLECARELTLAKSWRNVVELLRSLWQDLSFRAEGWLTIAEDLSWALRSAATVVGDASLVIAIDWELLSRSFTRRTNWHYDITRSLEGMAPQPRPKVCIKDGQLLPFVATSFSFGDEEGKAGQSTLGQLVIKSNAHQGSAPITLSNIEVKLGGSVSRIVLKHEAASKTTQHKHGAVKLSAVPLLDGAEGAEKAEPGHPDKADRKVTLHGAADLTLLPGQTLVFVMEIPLREPGETRAVSLTLGVESDAFELEHSLNFGEGSGVANIWYISASATKRIARASPNSVRVLPRPPKMKIKNPSWREQYYTDEPIELEFDLINEEVVEAIAKLDVDLFGEDTPAFSAEIDGHDVDESSSTSIVENDESRLQGVSLGSIESSHSLTVRLRLPPIQRSSRYDLTLRVAYHLSTDIGTPIMQTAVFQLNIVNPFEANYELLPRVHPDPWPSLFDYEGVADVSGDNDGAVASSHLTHKGLSQAWYLITRYASFASEDLRVMDVDIRLQTARTVRCFASKRDTAPGSPPEDAGGGGRVMLPNTIVEAGFDIIAQKSTLDDRSPATLDVSLVIKWSRCPNPSSASRNSPPINTTILLVPRFSLFGTEPRVLATVSYGLPTPVAVKVSPSPVPPSLLPRQPQLIILHVVIENASNHFLTFGLAMEPSEDFAFSGPKQTTLHLLPVSRRSVTYRLLPLGNKALPPSTPTTNVFGGAVLSNWIKPSLVVRDKYFQKVLRVIPAADGMKLDKDGGVLLWVPPDVEEDPEEEDESSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHY1</accession>
    <name>A0AAE0NHY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_495330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHY1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="600" mass="62928" checksum="1880E18E5B7F458E" modified="2024-05-29" version="1">MSGSYPSDHGGFASFPSRRSVVHSTKGIVGTISPLANEAGLRILREGGNAADAAVACAAVLNLVDPSMTGIGGDVFALFFDAKDKKVLALNGSGHSAANATLDDVCRDLNITDRVYGTIPVTSALSVTVPGAAAAWADIVELFGSGVLSLGQVLAPAIELAENGCPISEIASYYWVATEQELRSKPNGLELLKPDPAASQGHRAPLAGEIYRNSLLAGTFRRLAEYGRLGFYEGPVAEAIVDIVKSLGGYLTLEDLQAHGRQGSEVTQPTSIRFQPHAFTESGGEDGIDLWEHPPNGQGVVAQMALGILQALEKGGRIPKFKQQDHNSPGYLHALVEALRIAFADGSWFITDPHATALDTDSLISEEYLGKRAKLYHPDKAATGLGPGSPAYKTSDTVYLAVTDAEGNACSFVNSVADTFGSRIVPQGVGFVLQNRGAGFHLNPSHPNVYAPSKRPYNTIIPALATNASDGSLHTVLGVMGGAMQPQGHVQVLLNMVVFGMNPQVALDAPRICIGVSLPGKSTDPTKKVDQTVYLEEGIGSGVAEALQEMGHDVKTVTGMGRSLFGRGQVIRVLHDAVDGRRVHSAGSDMRGDGAAAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NNU7</accession>
    <name>A0AAE0NNU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_175518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3384971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1423" mass="158299" checksum="9FC98C9B0ABDB684" modified="2024-05-29" version="1">MSNTKALLRQVGDAIKQQKWNSAIETVNGVLEKDPKSYQGHIFLAFALDKKNRLDEAETTYLTATAIKPTDAQAWQGLIKLYQRQGSKKLKQYQHAALKLAELYRDADDMNKCQEVVDKFIDQARDQGEPLQYVEALDLILPGSPIYEALEGRVLRPPRAYEIQAQVVETDEKKRINTLIGERRTRIGARIGDVKLEVKREIYSQSRLGYLYGQLVNWVTDDEVRRTYEEKLLQYCYDRLLAWPPGEQKQKEAEIVRKLANDMVIIRHPFKFAWDIAINWQDHKEIQDWDIAVLRQYCLFFPDSDLNRVIMGFLSSAVSPFPKEKSEQDKPPTTDATEDDSEDDEDGGVQTSYVPITEEDRLLMMTEGISTADSLFAYRLMGEYQQYLEEHESNVELMRKALEQLKAERSRTDLSFRYTEDALSLYLGTALVFYQSPRHHQEAKNLFDGVLAHEPSSTPAMIGVGLIYEEEEEYDEAVDFLERAMLRDPENLRVRTESAWVKALKGDFESSRQELEVCIPLLVKKGQPAKELLAQTQYRVGYCIWNLDASKAARKSRTGAYAYFLEALKSNLNYAPAYTSLGVYYADYAKDKKRARRCFQKAVELSPSEVVSAERLAKSFADDGDWDRVELVAQRVVDSGKVKPPPGSKRRGISWPLAALGVAELNKQDYHKAIVSFQAALRITPNDYHSWVGLGESYHGSGRFIAATKAIMNAQKLEDAAGTEISGETWFTKFILAEIKGELGDFDDAIALYREVIVDHPDEDGVAISLMQALVMNALDSLGKGFFGKSISLATETLKFATQAPAAIKETFNFWKTVADACSVFSSIQSHVSDFPVNLIRLLIGQDDDAVEYQAVRDIDGVGTGIVTTDGIFPHDEALGVDLTRCLQATILAHKRAIHVSASDVHAQAVAYYNLGWAEYRAHGCLPVSLREKATRYLKAAMACFKRAIELEAGNSEFWNAFGAVTSSIDPVVAQHSFVRSLHLNERSADTWTNMGTLALLESDLQLASEAFNRAQSADPDHAHAWLGQGLVALLLGDPKKARGLLTHALEISESSSVATRRHYSVSMFDYIKESPAGVAISFLIQPILALSQLQGLQPQDLAYGHLSALFQERTNENERASATLEQICSTAEAEYEVTESAQALKRFALAKTDVARSYLAAGSFPKAIEAGELAIELSSIHSDSELTGEERLKLRLSGHVTMGLAQYYSGNLDEAVTCFDTALEESKCNPDTTCVLAQVLWATGQEEAKERARDILFEVIEREPHHVQSVCLLGVIALLDNDEESLEAVTLELQSLRASDEGVTPSEQSQLGEVLRAIAALDKGLSAEQQAAGQAQVDVMLHPYLPHGWSEIAEVGGEESEGASDMALRVALKGIPPWGHLEGEDLARAYAGTRRAADAQIAVMVAPWDKFGWLALGDVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NP47</accession>
    <name>A0AAE0NP47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_509989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NP47"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3385063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="550" mass="62146" checksum="E95DE6A615AD273F" modified="2024-05-29" version="1">MPHSLSPSSKAMPPSAIPEGEPAAPAIPSGQPADEDVTMADAVTVDVDMGSETVADDNTDAPVPAKIEPPEVKLEDLFAGVNSDDDDEEFPSSHNLPDKTSPSSPGSPSSPSDGGPSLQGSNPALMRTFYQRLFPWRYLFQWLNHSPTPTDDFKHREFAFTLQNDAYLRYQAFVSSDTFVYPVLHHLPYANPKFRLRKDVLRLMPSRFEIGPVYSANPRDRKTFRSSTAFRPLSKELCFDIDLTDYDDVRTCCDKANICNKCWQFITMAVKVVDVALRDDFGFKHILWVYSGRRGAHAWVCDKKARTMDDIKRKAIAGYLEVVRGGAQSGKKVNVRRPLHPHLTRSLDILKNHFQEDVLEAQDPWKSPEQADKLLQLLPDRELADALRKKWDSSPGRASTSKWADIDTIAKTSASKNLDPKVLLDAKQDVVLEYTYPRLDIEVSKKLNHLLKSPFVVHPGTGRVCVPIDTRLLEEFNPLNVPTVQGLIQEIDTWTEPEEAPAHPSQQDWEKTSLKPYIEYFRGFVVALMKDERDVKVKREREEQADSLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPS2</accession>
    <name>A0AAE0NPS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPS2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126922" checksum="D45548BF6FC50E15" modified="2024-05-29" version="1">MMKSLKFWRWRTPSEDTASPKKQDKEQPARLGGRSGESNDERRTDKQRQRWIREQEKRDKELIKASENNLNPAISADSDLFRDKLRHFGNLLRSQTTTIERILRTEFTPLQRTLLIPADKKRNPVMFEIQARNKQAYSELLRSGRFSSMAGQADLAFKFTLAWFGVSVSPMTINFNQRWKGWEDSDDSVDEMAPDPEGGLLRFMNCYQTRAFEKDVIRKPDPQLEAYYTIEQRRRPGGYYFDSMVGLRGGGADEDHDDGDMSSSPASDWEPSALDSASQARSDVKPSFGCQDPGPFSLRGGGGIGGVGEVFKEVFENAQPSIKSDFSRTEKLADREVLLGGEMGGANPSWIPLYGNQGIVWFRLDSFYSFIDAVDRVLGLDTRAGVNYTLHIRRKDKKSVKGWERFHVICAGVGDYSGDHPGWKWVQGQLGQLGQDAVTDRVIFISPRADQSPDEWEPSSASNVLKVLLRWPAIPELNRPDVAYIRMAENFVPQTNLYAEWVASACRLLAAGRIPNRPGQPAIPDASIGLLEDNTSSYGGLLLDPRSWQDMENGWQNDHSKPVVLMARARWNQGGTRDHLPIFLPSGTRDHSLQLIDNGITEEALSRAIVAYTKECLGLAEAERLWSVQVYVIGQHIYPSYETKDWENAGIFTLPVNGKTNQKYQNEEQVLQEIRAFLETTVNWLRSRVGSPPNDGLHLFPQFTTIVPRFRTYLAVDPRPPGKQKTSFEWDLDTTLEEFRDRVSTRLYKNRYDPTRDVITIREQARISSYMSSSTFVISPRTTDAQWEVIRRFITKREVNVTLEGEEPRFSSRAFGYMDIYTAPGVHRRPTDGPTPHRNFDHQLWSYIDPNAKVAGSKPLMPWDKQPPPRPPAAQGRKPAKPGQGGRVGPAGQGGRTNQGTAATKPDREMSDIEKGMFMRQYSYAHPLDVQMQGGIPINAPPIDTLLNLGYDNLPTVALSVLTPTETRRLQRDYHNIRNILLSRAQQCPHAGCDVVIPVSESGRMQQHLWERHAATKCPFCIEPLFEHWSLEQRAAHCSGAHYQEFVKFIGTGAKTGEEKQQQQQQQEKGKKQEQTPGKKRKADDEDESTAAGRPRPEPITPPRRTRVPPRKDKTTTLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQ39</accession>
    <name>A0AAE0NQ39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_544004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQ39"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="639" mass="69894" checksum="7A91E8870B64AF3D" modified="2024-05-29" version="1">MNAPIAPAPSSARRVPLPVISLESIREEHPQTLRPAVAEGSETAARTIPQRTRTASVDSNGVSPVFSTIENPFTNINFSTATAAAERTPSPQRPDEGEVLLPSQRGWWWWEIGAVALSAISLVCLVVFLVKIDETALESWSQPVEPSFLIAILTTTIKMAILVPIASCINQLKWRYLWRGESTTVEGLQRMEDASRGVWGSVLMLTRITSPRRQTIFIWFFCVVTILAIGIDPSAQQMLGISSRRVVMGSVVPGMARADSYAVAPHNDKKNPAQIDKDLLAFQAAYLQGMSGIVAPPDFRCPSPATECVWPNFDTLGVCGTLTVVNETYTSCEFTIEPSPILNCTYNFPGRIAPKPKGIYITYKVGQPATQTNISVEADGWGEATSAALAFIRAANPRTVVSNSTPPAIETFYITWTWCAKHFSNVTATPDRISSQSFTSAAVKLVPESLFHKETNAISHLDTTTGKVYRISYDAYNSLWVSLEDLSSSARIHNSLNGLMSRTQDLNSVAQNVAEALTNRIRGTVSIPTMALGRAYKKELYYTVRWLWFILPLAEIILTIFLLALCIVINMDTPILKNSINGYFALGILRSRSEEDLTLAGTGGGAVKVGIKAAAEDVVRMTVQRNGRNGLLETVRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQA7</accession>
    <name>A0AAE0NQA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_394050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQA7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="602" mass="67529" checksum="03DD912ABDF44714" modified="2024-05-29" version="1">MCTFDYTPYTGCGDGQQHFYLQWMKCRKAKENNNMFCPLEQSIEMEELRKLSGNILSCPIHNPICVEQHEFQIVHIEVNRLSPKRSVARRSRAGTLTTRPCSTTPRREKAMRDFEEHIHAEERRRRKAPHNSSADSDHSQDSNSHPMRPSTSGGERASNELPRNDDEHESIRRGRSHRRVSSADIPQLPARSLTRRDKRHPSLPRTAEHPANKEEEAQETEPPPKVSPRPVSTLGLPRGSLIGLGLPASPDIHRRASVAYRSRSEAALRQPSEDGSPPNYPEQSWDPLPPRPAHRRRGAGEPVASQGKGDDGVMGRIEEHVPANDAGNQEHGAPNIPKLHTHEASDHGSRDTIRLQSGTLHDRRRRSRSRRMESRERSDHQASDQRASSTRDPSPGITAVSTQGSKGDRPPQRRNSVRPDAAASHKNDQTTRGRRYEEQVAEGWKWVAAREYMPIANSMATVVAAYDMPRSFHQSQRSLSKRESDDSGYGSAHLQQQLHQQNSLAEPSVLPIRTGPERSATPSADDKSSRAVLQKPPPARPDRPTPLELSKSPLALPFVVVSPRSDPQQQVKTKLLHRMGLRRKFSGLWERNGQPGAGELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQK6</accession>
    <name>A0AAE0NQK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_449906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQK6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="132" mass="15303" checksum="8DFE456AFD541208" modified="2024-05-29" version="1">MSSPQSSPSNWASQPYTLVPDLYIPDPTADEVDLSGHPWMVATVIEDDDLMFGGKSLSAWYEEERRVSTGGSTTEEEEPRGRSRERPRMESSRHHNHHHHHHHHTQIFLHPQQQQQQQQPSHRCKPSKDVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRS2</accession>
    <name>A0AAE0NRS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_558213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRS2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054586">
        <property type="entry name" value="MACPF_1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22693">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF-like" evidence="1">
        <location>
            <begin position="243"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="589" mass="64456" checksum="48388F372352425E" modified="2024-05-29" version="1">MATTSFHVAIDSPPGMTFPSFPSSALEGGDPKKITLDMIRNKCSISNKLFFTIDGKSRVEDTTTLEYYMSLTPEGQKLLQPASTGTTTATETPAAAPGVQTFVVKVGDSTVQRDLVNLPGNNEALTKLLDSISKNTLERGTLPTFADRQLASLVTNYATNVVTGRIYSYTEPQELTELQWDAVLKNNRALHGYWYDFTLSTFVTAPKPAFRLRGAAPVGKPPTTATDSAPKQQYLPPLPPFYIHDSATVKVTEVRTQQQSTWIKEGFNSLAVGGSLGGGPSSVPVSVQASWEQEHSYANQRREATDVDSLAVTYSFPRAVIEFDTDTLELTDQCRRDALNVTTTAARDRFYREYGSVFVTRLTLGGFLYSTRNVTTTETATLDQVKDKTRIAVGISVQTPKVSGGINFAKVDATSTENSRASLLQEVSLTWDAQGGDTLLCTNPPAWANTVKDHRLWRLMNKERFVSLEHLVKALDTEAWRKLDNPSAVSNVGKDVVTDDDFNSYVRITLMDALKDGASDDSVIARKMLEYYEADTATKVTASNAFMKTNFPDETDAIIGAGKLFPGLSVDQKVGFGLYMTSKGALSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF3</accession>
    <name>A0AAE0NSF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_558319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="82985" checksum="AD09B1C01777698B" modified="2024-05-29" version="1">MEYAVAGIRLLSPLFQACQKIYTTIQDSKTFGERFQREKRWLDAEYAVFVDLGERERDHLAQPIDEHDTREGSRVLAIHGLLENARDIMESCEKLIQEVEQKSKELKKLQKPRPVTATTSSPSQTAVPADESTRPSLQLPDSELQSDRWTTESMDMTDATPSGTATPLQMETSLNTSISELSGPSKASSPAPAEADTKTKQKLSKDKGKKKEKKTTGFRSSVSSFFHGKKKQQDGAGKEAEVLVPQPEPAPEPEPVAGPSNAASSPPPSQAPPRPLAAEVRKTLDRDLVVSVTGPDGAVVTTPAPPSPPTIHPERGRMDELIEEIKGSADKLKGYHNDFTMNNKKLKKLLELKDGKGLAHPTPEAVEQTTALIKKVAPTQDSLKRLHQAIRSNNPMDAPKRVTLRLVADFEKAVEAARVELDYLPLRTEGEYFYFGLRIHDRSPDNPNSPEASEYVVETRMTYDKNDKNDKQSPIAPQNHKALELKRSSASTSAALKPQPATTGGKFELWGDAVYLQSDYARDLHRLFRNKDQVWKTVQTLQSFMQPDGYGGGAPTQMKLWQRVELMKLAVAAQLHLANLRPICRPLTLGRFVYYTTTTTPVPHASWWGADAPLVLKPFLDIGFGQRNEGLSEYPLNYIVELGIVLFQIAGCVAIGINTGDKQKEAMDWADEQFDRLNAEALVPLAQVARDCVRFAGEDDRTKEGEFLANKFLRLEELWRTKYNRSSAAGRIVPPRGGAAVVVRPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSK1</accession>
    <name>A0AAE0NSK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H63DRAFT_392638</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSK1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3386943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="926" mass="100647" checksum="FDABE1D3EE9E47D9" modified="2024-05-29" version="1">MAEHSTSGAPALSTNIASGKFDDEKETRTLNPAPIKKQKVEEEEEEDEDIDALIEDLESHDGHGEDEEEEEQVVGAGRVIPEDMLQTDTRHGLTTEEVNQRRKKYGLNQMKEEKENLILKFFSYFVGPIQFVMEAAAVLAAGLEDWVDFGVICGLLLLNAAVGFVQEFQAGSIVEELKKTLALKAVVLRDGTLKEIEAPEVVPGDILQVEEGTIIPADGRIVTEDAYLQVDQSAITGESLAVDKHKGDQCYASSAVKRGEAFVVVTATGDNTFVGRAAALVNAASAGTGHFTEVLNGIGTVLLVLVIFTNLVVWVSSFYRSNDIVKILEFTLAITIIGVPVGLPAVVTTTMAVGAAYLARKKAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLAEPYTVAGVEPEDLMLTACLAASRKKKGMDAIDKAFLKSLKFYPRAKSVLSKYKVIDFHPFDPVSKKVVAIVESPQGERITCVKGAPLFVLKTVEEDHPIPDEVDQAYKNKVAEFATRGFRSLGVARKRGEGSWEILGIMPCSDPPRHDTARTINEAKNLGLSIKMLTGDAVGIARETSRQLGLGTNVYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIYLGLWIAILNRSLNIELVVFIAIFADVATLAIAYDNAPYSKSPVKWNLPKLWGMSVLLGVVLAIGTWITVTTMYAHSSNGGIVQNFGNMDEVVFLEISLTENWLIFITRANGPFWSSIPSWQLTGAILVVDALATLFTIFGWFEGQQQTSIVAVVRIWIFSFGVFCIMGGVYYILQDSVGFDNLMHGKSPKGNQKQRSLEDFVVSLQRVSTQHEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSP7</accession>
    <name>A0AAE0NSP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSP7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="73" mass="7901" checksum="D780A71D50F318FB" modified="2024-05-29" version="1">MSIKKSLAIAAVVGFGIFNGIYTFQPSFEEIKARREGTHLDLNQNSKSQQPGAATEADSEGGPESQQSKKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSU8</accession>
    <name>A0AAE0NSU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_147960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSU8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="802" mass="87537" checksum="B7943F2E3F47FCDF" modified="2024-05-29" version="1">MDDDIVGHVYGMGPRIPAVKAREALKKMGTSTLGYRIPTRVLAARAAATTTECTDKQLCEKPAGSSSMGLAIGLGVAIPVVVGLAVLLYLHRRVVKKQRHEDLNDPHKSLDFGLDENVGGKPKRKSFLTREKDLSQSSRFQRQQMSMDMDVPSPYLLPPALNTSQDSLHSLARTLRDDDPYRHVANYPGSDAGSIRSMPRGVDGGSTYTRSSSRQQGSRLSGSMNANGQYQPPPRQNSLPRPHVVSPEPVHMKSPQQMPLDDASLPYPTSRVSPPYPTSKDMGLAHTGPTGLATQREDDENMLTTSPIQEPPSVAQRITRKSMGSPFEASPADSGVEMGFAESDFPKHHSQDVFVAPGPTLTGLGLVDHIEPTQPSIHMSTVDSLPVSPVPQRGQVGSTAAPIIESPFEFYEYDDDTTTADHSPIGPGSMGQLDADEGRGRNMHRQSSLYEPSLPQGGLTLPQQDNRRLSVGFRPLPPDEIMESEDPEYRANRIRSFYKEYFEDGKGEGAPPVPPMPPAQRMAQYQQQGGAYYEDYQGNYQEDAPYFDPETNAFVMPYAQPVSRRAMTPPPTGQRFQGARQPRAFHGSMADMRIPQGPGPHGPFRPGSGASRSMGPRPGSSASNAYRPRAESSASFGGRNAGHKKPMAPLMDLSTLPNPSKLKDDSFAILNAADFAPPDTYADRVRGRSQSPSGERRPYRPTVPAHSPLVNAFEELPTLPSPHLLRTENTFTGLDFAPPRKFIEADSRSETGSIRSNRSGISAVNVAAIRKGAGRVSRLPEDTIFTQNAMQQKLKPSWTMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSX6</accession>
    <name>A0AAE0NSX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSX6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="25182" checksum="A6BBBB2C24807C38" modified="2024-05-29" version="1">MSNFLTTVNQRTKNQFRPRAAGKGGATSYQLRQYAEATLGGGSLRKVVKLPEGEDENEWLAVNLVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMPAPAYIEQLMSWVQANIDNESVLPSRIGVPFPKSFPALVRQIFKRMYRVYAHIYCHHYPVIRELGLEPHLNTSFKQYVLFIDEHNLASGKDFWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NTU2</accession>
    <name>A0AAE0NTU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_493793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NTU2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3387626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="305" mass="33511" checksum="70A1459087D74213" modified="2024-05-29" version="1">MATKTSQTGQKKPIHYPFWFGGSASSMAACVTHPLDLVKVRLQMRTGDMPKSMSGTFVHIVKHGGVRGLYKGLSASLLRQLTYSTTRFGIYEELKQRHEATQELNNNGIKKAPSLPVLIAMASASGFVGGIAGNAADVLNVRMQHDAALPRAERRNYAHAFDGLVRMVRTEGVGSMFRGVWPNSLRAAAMTASQLASYDVFKRTLIQQTPMEDNLATHFTASFLAGVVAATVTSPIDVIKTRVMSGTGKSSIPKLLGDIYAAEGLRWMFKGWVPSFLRLGPQTICTFLFLESHRKVYRKIKDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUA0</accession>
    <name>A0AAE0NUA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_392798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUA0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08621">
        <property type="entry name" value="PI-PLCXDc_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3387857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="469" mass="51746" checksum="F84691BCF9B9CB0A" modified="2024-05-29" version="1">MTVRSSDGDALDELLEERASSGAYFLLINATPWALIKSYSHSYQMKTWDCPQNISPGTSTRIFMEGTGRPDDGAECRYTINDLNPAAFEIRYHQKFGATPFIPGVHVVFMGLETLHNPDGTTLTLEWRRDNNMPFVLASSELHPSNPSAQIVSSNPPQDWMHATYSRISCLSLCELSMPGTHDSGMSVFSGGSGLGLPINTLTQELNIREQLQFGARWFDIRPVIAGGNWKTGHYSFHDGTDAWHGGNGEEIRSIVDGINDFTANNKELVILKLSHGLNTDTFAGDKDNHLSQAEWARLLTFLEGINNRVINRGSTPDLSRLRVSDFISDNRAAVVIVVDDVVDSRGTRVQISAAAADKGFFQPGQLPLYDSYANTNNQDGMISDQLGKMARQRPNPTADMFLLSWTLTQSGLSIIDNAKGANYALEEKLWPAMSPSSYPNVIDVDAYPRRGDVAALSMAINYHFARTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUI5</accession>
    <name>A0AAE0NUI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_559372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NUI5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3387942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="230" mass="26252" checksum="4B58F04F9E9E289D" modified="2024-05-29" version="1">MSPNDNLRQKASFEDSVRSSDDESGMTLLGEHMQLSSPKKRSRFHIILRLLLAATALVCGVSIVYTAFAVHSISLSSTTDFGDCGTQGSVEEARAKGCKFDPMSWIWVRPECYNADLIADFMNRTEFSWHTEPKLKPESRVPLDVVFRGDHPKLFTQKQYHLVHCAYMSKKLLKSIIDHTPIDDYLVSWKHEGHCEMVLLNDYLHEDVVCEAPKICPTHVQATWTTCKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NWL0</accession>
    <name>A0AAE0NWL0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_388971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NWL0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3389163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="501" mass="57209" checksum="C8C77E3B5282CC55" modified="2024-05-29" version="1">MDWTTTLLVAGLLSVVIGGVRRVWFSPLSGFPGSKFAALTLWNEFYWDVVKRGTFMWRIEEMHKKYGPIVRINPYEIHIMDPDFYHELYASNRALDKYRWWTNLAGADGSGFSTVPHSLHRLRRSAMDPFFSARSVTQLEPVLRSKVEKLSARFQGLADTKEILRLDAAFMALTMDIICDYAFAKDRKYLDEPDFQLRWKETIIGAFEGGALGRQFPWMLPLMKKLPLSVVSAMNPAVGYLFQWQAGVKEGVKPILEHADEVSKTGEASRTIFHTLRDSDLPAEEKTLQRLCDEGEILTGAGSETTAMAITRIFFYLKHVPETLATLRREVDHAIPDASDIPTWAELQSLPYLNAVVREGLRLSYGVTTRLPRIAHEDIKYKDYIIPAGTPVSETPYFVLMDPSVFPDPTVFRPERWLEAENAGQRLDKYLVSFGRGTRQCLGKNLAYAEMYLAVATVVRRFDWELYETRLDDVICKHDFFVAVGDLNSKGVRARLQVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX06</accession>
    <name>A0AAE0NX06_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_408971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX06"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="815" mass="89906" checksum="E4BEFD7AFE970704" modified="2024-05-29" version="1">MATMASPPQTQLGSSSSAAGSAAHSEPLTPGTAQSSSAMMPQKRILACVLCQRRKVKCNRKFPCSGCLRAKVPCVPASRAPRQVRRRFTERELLDCIRSHEAILSHNRIAFQPLRKDLQSAASEMEVSTPEHLDHDAGFDSEADERSAERDVSSSSPSVVANTYRGERNYEAKSYWRAMTQGFRDPNDPSYDSDDEELEAAHVHIVNSAWQRSYESSDHLLFGSTPACIDLSTLHPDPVQIFRLWQIYLNNVDPMLKVTHNSTLQNRIIEAIGNLKAIGPALEALMFSIYSIAVFSLEPVECQTMFGLPKEDIAVAYRFGCRQALSNSAFLQTNDRDCLTAFFLHLVSLGKDTHPQSFSAMFGVLIRIAQRMGIHSEATLAQHPPVEAEVRRRLWWTIVMFDHRVGEMSDYKTATLLLPTWDCKIPLNVADSELRPELSELPAPAARFSPTEAIFTVVRAELGDHIRFAEFNLDFTCPVLKPLARDDVGGLGALSQTIEDKYLRLCDPNVPLHYFTIWMARYYLAKNRLVEHYSRQASMRGQPPEVLDKQRDLALSHALDMLTCNAKIRGSPLTARFSWLVHFFFPFASYMHILQDIKTRPLSRQAGQAWEVMNENFEAQSVEAVPARQEAIFQVFCHGLVEAWSVCEAAIIATTAPADGEAAASPSSPPPKPPKLIASIRLALERLAAQQAERQRRQQQQYAQSETSSSRSDQIPPGVAMDSFAAMSAMGSSMPMGMVGGSSSTPGSSGVMDAFLADGSLHGMMWMQQSSDAGGAFGGQPAGSPSDVSGGSGGSQFPFQLDFDQLTMNWGGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXB2</accession>
    <name>A0AAE0NXB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_463407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXB2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF28">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3389330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="513" mass="55503" checksum="4E05A504986D5441" modified="2024-05-29" version="1">MDEKKDVGLGGIEARAGESHEVDFINVLGYKPELRKNRSMFTLLFQSLAIAAIPYGFGGPLISAIYGGGQLPMFLGWIMVLLVDECVALSLGELASRYPTSAGPYYWSFQLAPHNVRTLLSFITGWTWLIGNWTITLSVNFGFASLIAACIAMFHPDFLIESYQLLLIFYAICIITFLVCAYANALLPLADTLCAGFTAVAIIITLICLSVKADVGRNSPSDTLGHYDTSLSGWDSFSFFIGILPAAYTFSAIGMVSSMAEECEDPTVKLPKAIALCVPVGGIAGLFFIIPICATMPPLEDIITAPVAQALPYIFQRVMGSAAGGMGLTALVLIITFFCSVSITVAASRCTWAFARDGAIPVSRLWKKVDPKHETPIYALALVTIVQMLLGLINLGSSSAFLAFVSVGVISLAVSYAIPIVISMWHRRREVNAARWTMGPTIGWPVNLIAVLWIAFETILFSMPTVLPVTEVTMNYAIVVFAGFMALSGLWYAVYAHKVYKGPPESDGLVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXI1</accession>
    <name>A0AAE0NXI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_463812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXI1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3389501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="318" mass="32993" checksum="419492F97B1D1EE9" modified="2024-05-29" version="1">MSFPPRSEYLSAVWADGIFANRVLFITGGAGSIGSAQTRAFVRLGGNACIIGRNVQKTEAAAKEIAKIRDGARVLGLGGVDVRSFDALKAAADRCVKELGSIDFVIAGAAGNFIAPISGLSPNAFKAVIEIDTIGTFNTIKATIPYLIESASQNPNPNSSGTTGGRFLSVSATFHYTGMPLQAHVSAAKAAIDSLMGSVALEYGPYGITANSVAPGGIEGTEGMERLASSAISREDQTKSVPSGRWGSLRDIADATVFLFSDAGNYVNGTTLVVDGAAWRRQGGAGVGLDPSMTYPGFLLSGEVSKHVKSGRKEKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NY84</accession>
    <name>A0AAE0NY84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_492579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NY84"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="275" mass="30291" checksum="51C48C99BE05D9BE" modified="2024-05-29" version="1">MSNANDSEPESELFHLSINPAAPTTIVFIHGVLSCHLEWAHVTPFLASDYHLLVVDANGHSGSAAIQPTDISSSADRVAALIRKHAKNEKAHLVGLSMGGFIALDLARRYPDLVQSIFVTGAHPFRGLFKWMAEHPSVVWYIMGAFEALPDSLYFGLARWRGMVRHEELRKETTENRRWETVRDVYGSLLAFGWDEVSGVNVPAAVVAGGKQDDVEATRMMGPLLRGEGGSERSKAFVVRKAVHAWDLQFPELFAAGLRAWIEGGDMPGAFEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYE8</accession>
    <name>A0AAE0NYE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_104777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYE8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3389839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="330" mass="36647" checksum="3C134A22A0035492" modified="2024-05-29" version="1">MAPRTDFPPVRACLFDMDGLLLDTEDIYSLCVNIILQRYGKPGGLPWSIKAKLQGRPGPAANKLFHDWAQLPISQDQYQKEYYELQAQHFPATQPLPGVEKLLGDLGRTRYWDLKKEQHTSTNGNGASHNDADAAVTPKNRVHIALATSSHEANFRLKTNHLTELFSVFEGHRRVLGDDKRIPAGRGKPLPDIYLVALKTLNDSLPPGEKPITPEECLVFEDSVPGVEAGRRAGMRVIWCPHPMLLKEYKGREAEVLAGRTGEAGDVDLHQVGEIDDGWAEFLPTMVDFPFDRYKITVPPVSVEDEPCMKESGIIDNGEVMQVVDGATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ62</accession>
    <name>A0AAE0NZ62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_113106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ62"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042277964" description="glucan endo-1,3-beta-D-glucosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3390388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="462" mass="46499" checksum="86212E844031FDF5" modified="2024-05-29" version="1">MRAVSALVALATVISSVSAAGPYQGFNYGNELAPGVGKKQADWEKEFRLAQALPGAPGNGFTSARLFTSIQMGSASDPIEAIPAAIATKTSLLLTLWISGGNFLNELQAVKTAAAKYGDKLAPYIAGISVGSEDLYRISKVGMENPNAGPGVEPSKIAGYIRQVREAIKDTPLKSAPIGHVDTWTAWVDGSNRAVIDACDWIGMDAYPYWQNTSGSNAIENSKALFEEAVANTKAAVGSKDVWITETGFPISGIPWGQAKPGPVNAKSYWDQVGCPRFGKTSIWWFSLQYTPKNADDQDWGVVSNAGKLNYDISCKKDAAVSSAAPSSTPASSTPSRPSSTTAAGSGGGSGTGSGSGSSTVGTSGPVSSATTTVINSNPGGGAGSSSSQLSGGVSSATSSASRSLGTGPSASVSVPGSGSNSTAAPSGTPTPSIVPGSAGVRAISGSIGAAFAAVIIAVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ68</accession>
    <name>A0AAE0NZ68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YL1 nuclear protein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_507753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ68"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3390403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="207" mass="21897" checksum="2CAD55DF02AF00D5" modified="2024-05-29" version="1">MSTNPEVLAAQAAHLAVIEQLDIHSIHKTFRNPHWRPNQRRNKNIKTILGDASRKEASVIATPLDNSGAATPAMDDGLSTSGTSTPAVPSSANGNGNSLQPNLAQASRSLSKLVLEKSLNPSRSVANGLGGGSSTGAPTATYTNIESAPSLAPLRHYCDVTGLPAPYLDPKTRLRYHNREVFGTIRSLPPGVGEQYLEARGAQTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZ92</accession>
    <name>A0AAE0NZ92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_114313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZ92"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15868">
        <property type="entry name" value="R-SNARE_VAMP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3390419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="237" mass="26195" checksum="49F459184177548B" modified="2024-05-29" version="1">MASSSTPATPLLYSCIAHNSTILTECTTSASSQTSSLASLILPKIDHSSPQKLTYTHGAHHIHYMAESPSEHEPSTSAGGLTFLVVADSALGRRISFGFLVEARRRFFAQFPETTTNFDDMPNYGTGGFNAELKKLMVEYGTTGQGRDDALSNVQREIDDVRGIMTRNIEGLLERGERIDLLVDKTDRLGGSAREFRVRSRGLKRKMWWKNVKLMSLLGLVLVLIILTIVISVKNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P024</accession>
    <name>A0AAE0P024_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' exoribonuclease family, domain 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_124834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P024"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="41"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3390868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="30622" checksum="9CE5EB75C778C22A" modified="2024-05-29" version="1">MTDRRRINGPVGATIPLVFEDVEDYEQVATKAARSRAPNAVRKMYLKTGVTPSASGSAYLEIETSGKGGVSGLKLSCTVYGPRSLPRSSPFSPHIILSTHVKYAPFATKQRRGYLRDPAERDLGSHLEAALRGAIIADRWPKSGVDIIVSIIEGDQDRETSKTQGDEAWDIMNALSGCITVASAALADAGIDCVDTVAGGVAALVRDTADSSPSIVVDPIPSEHEKILASCCVAYLPTRNEVTNLWYKGDLPASDMELYTKLVEKGIQASTNANRVLLECLGETVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P034</accession>
    <name>A0AAE0P034_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_123173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P034"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="145" mass="16336" checksum="678637A74FFABC83" modified="2024-05-29" version="1">MQCMQMLCSLCVRTPHVWLYSGFFWVVSRKEGSLWHRRCMYVPYLLPCSCSFLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDDLLSLDVNLQSLPFGTAVSPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P478</accession>
    <name>A0AAE0P478_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_554369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P478"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="299" mass="33072" checksum="A0DD52A218F62A8B" modified="2024-05-29" version="1">MASSTRSRPMQHIDRKSLYTSLEARIRYLHSFLDFGTNDVEALLSGSKYIQALIPAVVNIVYKKLLQYDITARAFQTRSTAFEGPMDDVPDEESPQILHRKMFLRAYLKKLCSDPTQMEFWEYLDKVGMMHTGIGRQYPLHIEYVHIGACLAVIQDILTEAILSHPRLPLARKVAIVKALGKVIWIQNDLFTKWYVHDGEEFTDGMDFGEIEKEGWLHGKKVLHEEVEGDAASEAASDDTAVGTSPASPTRSTGSKIPVKGVCPFTGVSASMEKLKVSPGSKSGAGEVEADAAGPNEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P4W5</accession>
    <name>A0AAE0P4W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_406551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P4W5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="343" mass="37893" checksum="26AE46294BE6C52F" modified="2024-05-29" version="1">MPSLPLQAKIAIRDKWENGDALQSSLKNLAAIIGLPVVIEPEWHLLLAELDTFYGGDRALLVTSIVNCVVDWTTAISEIIEDDSLESWTELLLEAVSGRVLIFLEVSDKNTSKMSTSWSEARQGFIITLPKKQLDRSDELLPTFRGNLLACFGGGGVKDESALEQSHTTEAEAEDDWANVVKVEASGKVVEEPTRAVQEATATTTRVKTKTLPKLESLPRPDELFKKAPYYLTIGGSSDEIHVEGSHSPSLKLLADYLTRWCRVNHQDSRKPPAVQVILKQSAFALGEWYDLVVLTTKETRYSLSSHVSVATVAAFVEGVLEYDRISTQGGSLMFRRDVAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5V0</accession>
    <name>A0AAE0P5V0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dockerin type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_30756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5V0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15892">
        <property type="entry name" value="BNR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3393911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49900" checksum="413A61E9706DEE43" modified="2024-05-29" version="1">MLLPEPSVTVLGADPAHRRCILNGNAFQQDAITSFNGWQYAAFYSFLADAAPEPLYVHLARRQLPHGAWEVLVLDDYPQTVDDGHNTVQMGICPGDGTIHLSYDHHCDVLRYRYSVRKLAKYPAHFSWTSALFTPTLDYLPGLPSTHPHFSYVTYPRFGAMGNNDMFCSFRDGKAGLGNDHLYRYSASTGLFTFVGTPLTGIQSNPYVHGLDFRGGRLHVTWVYRGFVHYDGWDDLLDEKHKQQAGPNGAENNHDICYAYSDDTGSTWKNGEGKVIADLRSVGGTVDNTAEGIVAFKIPKGKGLMNQEAQAVDQDGGVHVLNRDTMDGGKHLWKHYYRSPAGGEWTQRALAPIQPGSRRGRLAVSKDGNLYIILPDITTLPGRIRILKAAKADGYAVYEEVWAGLGFTGEPLVDATRLEHDNVLSVFLRRDVVDGAELGEKDVVILDFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5W4</accession>
    <name>A0AAE0P5W4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_516741</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5W4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="294" mass="31841" checksum="AA314AC5BE1E6440" modified="2024-05-29" version="1">MLLRNPDPDVFRTMDPAHDDEDMPPPPPQGYHEGHTDNNANDEGDDLDDIWEGDANTHDDNGQPTAAAVIPPSNTHRHHQQHNHPSDVPRLQQEHTTAGYRDGIATAKGASAQSGFDEGFGLGATIGAQAGQLLGMLEGLLGAVASSSASKSHSYDEKEISRLQDLLAEARRELSVQSVFGEAYWAMDGTWNYDIPEPAVSTATPEEDDDGEEPVVVFVDVAAAHPLLAKWDGIIRAEADRYGINWDVIPPADDASRRDEDERENDAETRRKDAKAAAAPATAGERDARGVLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P610</accession>
    <name>A0AAE0P610_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_31298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P610"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042269574" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="106" mass="11739" checksum="C2AD1DA118D2B11A" modified="2024-05-29" version="1">MWFIAHLIGLWPTSSSMANSDPYSAVGRIKYALNRPQTAPPASKSPRTIAWLLLHCRSRQLSEIRVPLQTSRVSRVRRPSLAWALGRENPRGILDPALGPAQGQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P641</accession>
    <name>A0AAE0P641_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER protein Pkr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_32425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P641"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="18575" checksum="ADF7982CE99FEA3B" modified="2024-05-29" version="1">MAAFLTELFESIFTPGPTPTLLVATNVTFAALQVVLAALLVATYSVHFLILSVLSGGLWTAINWFARELGEHQQQEEEKARRAAQAAVPAALTSDDSETEVEGTGSTGSIGKEGRPGPPKPVFAAVATEVEPLEQHGELKHRVVAEEAASSQGTRSSASTEDEWEKVSENEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6P2</accession>
    <name>A0AAE0P6P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_555610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6P2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3394383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="507" mass="56066" checksum="A54238D18A8E1994" modified="2024-05-29" version="1">MNCSICHRSHSAKKLPFLCAVDARNQLYDGRVEFAQALIQSEEVERQVNEALATQADGTRQPASLSRAQIDRLKSEEEAVADRTRQIIAQADRLREEIVAAREEIEAKKDAIERKRSDLEILSSGSPAKRNRLREETERSLQRTRYKWNRSTDTMAATRAFLCEEAARLYGLRQVKKGNVKRYEIGGVEIAELHAMNNVTPEVLSTSLAHIAHILVLASHYLAIRLPSEITLPHRDYPRPTIFSLPSSYRHGEVPFPDPALPSPLPGGEVDSKQRGPTPRPLFLDKPLATLAKENPPAYSLFLEGVSLLAYDIAWACCSQGFSFGEKDPYEDICNMGQNLWRLLIGNQLHRRSVEPAFPSSLTPPTGSSPIKVEDEATKPKSMIGRWSHGTTHTFLGSAEGSEFVRNFKIMTPLKLVDRLKKRLLRDVPMVEWEKIEGDEIEEAFDDGVFVRGHGSSAGGAGEMLGAASIMTIRGASVGASAAGFEDSNAASAGKGTNGWTKLKNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P702</accession>
    <name>A0AAE0P702_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_499022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P702"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96479" checksum="05E77AAB4EC7CD50" modified="2024-05-29" version="1">MLCSFHFPLQSHLLPSPLLITYTYVSLHQPLWSHACRILPLTGPNNNTKKRRPYCHEDAPAEQVLQDLSRFPSTGPDSLPLLSAKHQHYILGQLPSTLRVTLGLPVFKLLALDPAELQLQFFKQASKSTGISLQVLVDASRQRQQPPHKKPRPNPSIHMSVPYSDDPEDQNVLEKSHIGRQPGSHSANAARRGISTLHNGAVESASNCWTGERSAGCFGGFSLCAPCPTYDQQQNSAYDPLPVTASFDFNSVRPAFDEDVLSIQPQGSSPLGSTTMATNETSFFSCDDPALIQYQYIPNYPPLQPSRALDGMQSPLLREEMVYPDTSSAATFPSETNNSRNSGLHSRNPPHVLNRLLLPNTMPSSYTAEVDSPAFNRNNSFVDASRYPSSQGVDVKCEPGGMDVRTVSYNSQRTFPAKRGPFTDNDKREKTARTRKIGSCIRCRMQRIRCNEDEEEEHGPCLSCKKILANISTNIKVYRLGCLRWKITDVKLFKPGQVKGYEWTKRWDNNVVDDIGNWASAELKNIQVTYVTPEGVPTTRVALRVREFRPQPGDKEERTWFSGGVKRTVKIPTFAIVDMESAKKDFAGFIEHGILECRNLLLSGKELLWKTYEFVIKMVMNPATSDAEQQLLTSTLNLWMSVRLTTKSFEIVGDERLGMEQNIIDDQGNPLYGKLPLPPVMGAQIDSILIHQIQPNLRRKTLEDLQKMTQDKKQKTWLTTYLVTFMLLHNLALITDHDAQYAKKHEMQRRWAREQNVKEYNLGANTLLAYFHYCNKGVYPFSSECKDHELQGLAELDLNAINLIKETRRVALNHKRYWETLWREEKYEDEYYYVSQLFEENWQPRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P724</accession>
    <name>A0AAE0P724_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_47069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P724"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="385"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3394472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="489" mass="53095" checksum="84488CA6E36F8471" modified="2024-05-29" version="1">MSLLPVALYGLEVPPGDIMVPAAIEFPATIRITMAALDPTAPAEADENGEIPSVPRATLKIIKASNQHDDDDDEEEDDYLESLLNGDDDSDDEEANGGPSDQSKSKKAKTEAAIKKLMAATQEAESDDEMADAPKAKKGKAKATEDEEEDDEEESDDEDDLNLEDYVICTLDTERNYQQTLDITVTEGEQVFFSVTGTHTIYLTGNYVIPEGEEEDSDEDSDDDDYDLPPGIEDMADEASDDESDDLDDLEAVQRIKEIDTDEEDAPKLVKAKKGKNKRVAEDEAEGLDDMISKEDTKEEKKLSKKQQKKLKNNQGEPVAAEVKAAAKESPASKSDKKVQFAKNLEQGPTGPAKEQAEKKSSVKVIQGVTIDDRKVGTGRTVKSGDKVGMRYIGKLQNGKVFDCKSNSAPTQPFSTNESTLANKKGAPFTFKVGKGEVIKGWDIGIVGMSVGGERRLTIPASAAYGSRSMPGIPANSTLIFDVKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7J0</accession>
    <name>A0AAE0P7J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_533062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7J0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="382" mass="42245" checksum="304CC3E283A745ED" modified="2024-05-29" version="1" fragment="single">RRTSNFCVFPRFPIRPRESQQQQHHQQQDSFSGDPFIPRTLPPLYTGQVRLLPPLQPGSYSSHAGRPQHQRPSSPPPPPQQQQQRRPDTETPPKQSPQHVRSRSQTVFSASAKPRPLRLVEKNHKRKPPVFFASHTHSLLQSLTYITINPQNNNNNNNNNNNNMASNPALMPKVVSPPLPSLPSGPRPSAAGAGAVSKEDLLADLRRQLDDSASSAGSSVDSRGNRRRRRNRGNRSNNALASASRNDGLAGPAIMPRLAETKPVRLQLGLNLDVELELKARLQGDVSLTLLVEKKHPAPRPASSTELRLSPNVNGTIGGGCEELFYVRIGRLQFRQRWIQREVSESLTVAMGMALVAGGFVAGVVIGRWWDDVLLFAAAGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7J2</accession>
    <name>A0AAE0P7J2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 2/VPS13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_56790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7J2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3394744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31707" checksum="F0C0E4AECA4ADE44" modified="2024-05-29" version="1">MLITRCKPCPIVESQVLSLETKSRSTFIPISSVTAAAMLRAGIQSAGYMRPHQYQKYDFANSLGSAVFGSLLERIPGINGRAKEGPNSSRQNLDPFAPRTPKNVPSLLDMSASAAMSTVRGIGSVVAATLKAPIVMTEKLARGLHNVPRLYGDSTVRSEQEVEDWRSGLAAANQGLSQGFYDGIAGLVTQPIAGAREEGMMGFVKGMGKGIGGLILKPAAGACEVPSYTLMGLFKEWEKLGRVDIDRQIVMGREAQGEEEYERLSEGEKSEILKAWHACEKAAELANSTSGRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8C6</accession>
    <name>A0AAE0P8C6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_492153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="94"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3395189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="539" mass="58308" checksum="37F36115F2F94290" modified="2024-05-29" version="1">MAFLPAAAGFLNATSMEWKGVDSKSPTASTLSVGSSGCSDEKHQGCSTAASSTTCFVARPGDYSDDTTINIVSWDGPDDPANPKNWSVRRKWTASLIVSGFAFLGPVSSSIAAPALDKIGEDLHITPGISLQLVLSIYLLTSALGPFVLAPCSEIWGRVPILRIGNVMFVLFTALCGFATSGPQITAFRFLAGVGGSASLGMGSGVLTDCWRSEERGRGIAIYQLAPVLGPAIGPIAGAYLCQYGSWRWAFWGNALFCLCLQAIAQFFLHETYPPRLLHVKAQRLRDATGDVSLRTQWEADNRTLPKLLRISLSRPWVLLGTQPIIQLFALYQAFNFGMLYLFISGFPALWEGRYGMPKGLASLNYISIAAGSLLGVNICGPLTDAIYRRLKKRHGFTEQQPGLPEFRIPLMIPASLVMPFGIFLFAWSAEAKLHPIVPNVGVFLYAASSIICYQCIAAYIADTYTLYSASASAACSFLRSFAAFIFPLFVPYLFGSMGYGAAGSMLGCLAIAIGIPTPILFWAYGQRLREWSRFAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P8D5</accession>
    <name>A0AAE0P8D5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_499275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P8D5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3395102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="337" mass="36383" checksum="AEB2A77E83DAC80F" modified="2024-05-29" version="1">MSLQGEHYFQVLEPRPYVYIGLRFADACKHHFGIRYGIRQHVPWPDVLEVAADLCDLKADLIVTLGAGSRTDGAKVAALAVANEAFTLDALDGLHTAASPLPKDVKACTISIINIPTSLSGGEYMAPGAATDLRSNRKLGFRHPSMGSQLVILDPVLTVSTPDRVWLSSGMRAVDHCVEGLCSVFFRTPSGEEGTDDDNTNKLKEETEEALAKALSLLLPGLLITRHFPSDLPARLEAMAGVVEANGPAVRQEERSCVMLPSVLRWNRAYGDAWVEERQRKERGLRRDTVSAGDVVAGFVAALGLPTSVGEVGVGRDKLDALAESSEQVLEIVEMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVI3</accession>
    <name>A0AAE0TVI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_523844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="255" mass="27495" checksum="7F257F193490D9F9" modified="2024-05-29" version="1">MNETVSAILGLTGGEACEVLLCLAAFPDSRRSIDDALASIGARNTAPKLLRPETPPLSDAGEAETPPSPPPPVPPIRTTSRHPKPGTATQTADPPPYSGPVLAIPSRRLFTLFSRTNNNFQSLLRPSDLQRAQTTSLPTTSTAAAVARTPSDRPLSLPCQGGLDLLGQLDLAAARAGTPWTSTPQHEQQQAIQQSLLGQHHTIEERPKIATNTNSDLVRICKRCHRLFRPGEQNYCFFHTGMSTLSLISSLYFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW47</accession>
    <name>A0AAE0TW47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_213152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW47"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3381727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="572" mass="62558" checksum="AD01B672E4113D8C" modified="2024-05-29" version="1">MSIMAEPGHTKFNLTYPPLPYSGSPVVEDPSSEGNADSIIPGILFGILVPHIVCTVIILARAWSRLFLLRKWFLDDTLILLAWIFSTAVCIVYSIAAKSPGIHATMTNDYNYASDDSNTAGEHEQAALRPYMLRTYIGLIFYQLCLCLTKLSILTFYLRIFSSRPVEKRLAWATVILVLLYGCPLLFISVFQCHPTTGHFFGTPMKCFTFVPMLIASTSLHTATDAWLIVLIIPCIIRLADLPPRQKAALALVLSLGIFVIAASLTRLQLSLRANYRPEVGDDGDADGVQVVAANTLAFFVMTVLELDLALICASAPTLRPVLARFWPRLMGLGEPDVASSGDGGAGQRRWVSDEDGRSVDLTSVVSYHGYPWTQPSTPLPQLATSPSRSKNPSMINIPSAPPSSAPSVLVPPVPPLAVFRTPTTLSLRSFMSSIAPRSRGHTTSSGRPAEDRTGLLDGQSPLDEVERKRRSSVGFEGYYDQYMGYNNGVDDNQSKRRSRNMKRYSGTGSAGRYSGRWGDSQESFVLGMNDPNSPTRLSPILSADSGLRGGLFVGRPLTERGLESRGKDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW56</accession>
    <name>A0AAE0TW56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_561445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW56"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="111" mass="12218" checksum="4B4D273FCDD33CBE" modified="2024-05-29" version="1">MPAPQRVIVERQGASSRSSKPQGFVASTYETLTSPDNASVVRSLALFGAAVTFLTSSWSEIIMSAINNKSILSLAPRTLDVEPRGSEDPVHHHSLYNIDSMRWLLGRMDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TWA2</accession>
    <name>A0AAE0TWA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_396977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TWA2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="176"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3381818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="793" mass="91103" checksum="C724B180FBAA8E22" modified="2024-05-29" version="1">MQSYSDTSLEADDVTECLVEWNLDGPHVDDAQKFVNVSRRLRISWTRKPTTNEGSPSRRDKKEEVYFIYTPPAPAPTTQRPHLVGHDIGPSAASTAETPPSPVRSLDTYEKSERLILNWLDTCEHKHAGMQPLSLGERLGRFRALLASTYFGVIDVVSKRLCPLPIDETTGKPARFAALSYVWGSGSESERKHAALWTTRKNVLSRAKNYGLADDWERFPRTIRDAMKLVKDLGEQQDPNKPQLRYIWVDLLCIVQDSKRSWRDNADNMDLIYGNAYFTICAADGDSSDAGLLSLDPSEMDRPRRATITPDLRLLVSKESESIIEASEWNRRAWTFQERILSRRCIVFVGRRVYFQCRQTNWSQDDNPGETGNGMSSAWRISLHRVHEELEKRPIRFYMTSVAAYTGRSLSQPQDILNAFSGVTQLLEWHLCADMHFGLPTSHFDVALLWKPLAGKHRRKPENLSTETNKDWGDLEFPSWSWSGWMHSTADPGKGVDVVYDADFLFGCLTDFRDWLLNHTWIVWYVRDKKGDLRPLWEGPTVPPASSSRAGHVAHRWRGYKSRPRKGAQWVRYLDTDENRAAGGCVTDDYGRHVESSGRRHVKGEQHKFYRLLPDNPFGLRGPDLDDARSYMFFTGSNSYMSFGEVSQEYRPYQPILQFWTLRGEFHIVRDDGGEGTSESAQNGLQRFHVADAQRDRCGTVVLDKTWAEKNKKDGKMCTFIALSEARSFTKEEWDGWTHYIPSACDDSEWCLFYVMLIARDEERLVWERVGLGKVFQAAFWNDGWSWEEILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC5</accession>
    <name>A0AAE0TZC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_472198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="64"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3385030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="195" mass="22226" checksum="4D42B861785DC143" modified="2024-05-29" version="1">MQRLTCVLGSLLPQTYLPNRGLFSLSLRFARYEAFDAAYDQEHLADARKWHRSFRLNSLPRGNTSFSRSSGPGGQHVNKTESKATTTWPVSQLLVSLPRILHPAVRSSKYYSKSSDSINIQAQTQRGRTTNTEENHKKLFEELQRLYEKAVPGETSEEKATKYEALKKNASETRLRMKKIQGSKKLSRKGYGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZC9</accession>
    <name>A0AAE0TZC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_449035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZC9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3384939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="11941" checksum="D70106B234DDE49B" modified="2024-05-29" version="1">MTSGPWWCREQKFILISKPWAEDVSAPGDSAELDATPILLEISQNCPASVSESRLGANAMECPTCRAGGPTAKYLDPRTMTATLRVNVPSLTYRNSRYVPDDHSRAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZI3</accession>
    <name>A0AAE0TZI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein het-e-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_472679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZI3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="216"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="418" mass="47446" checksum="CE61AD8AA8E0A01B" modified="2024-05-29" version="1">MADPISIGASILAFISLADKIIRASRHYLATIQDAPTDIEMILGEVSSLKAIIASIGDLAQQQRQENASPRLVSSIFSRGGPVEACRRCLVALQALLPEVGGGDKPHRLIISQLAWPLKESKARKLLAEISHHKATLLLAISGDVSHGLQDIKAELQKLQDSMSDSERREVIHWLERINPSPLHNMAFAKHEPHTSIWLPRLPEWKSWLDCNAPNRFLWIHGLPGAGKTVLASFIIEELRQFCQNSPEGCIYVYYYCHYSHNQDEAKPFLSWVLGQVCRQTRWVPRQLEDLYDRGWEASIPELENILEIVLERLDVLYIVIDAVDESCPREDLLGLIATMVLDKRFRKIRMLATSRPYYDIERLFSGISASISMSNTLVDADIRSFVHTKIAASRRLKRWRHLHAEIEEVLVKKAEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U104</accession>
    <name>A0AAE0U104_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_430714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U104"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3386917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="551" mass="60363" checksum="7BDD48778812BD71" modified="2024-05-29" version="1">MSLFKKRQPSPETSVSQKSHSPQKDPVAPLISEQRVTLLACFLGAVASIGGFMFGYVSGQISGFFDMVDFGERFGQGFDPVTGTYIFSAARQGAIVGLLPAGCLIGSLIAGKIADSLGRRLAISVSALFNCIGIIIEISSEHSWAQYAVGRLVTGFSIGSLSVLVPMYQSESSPAIIRGVLISMYQLFITLGIWTAEMINYGTHHMEGSGSWRIPSGIAFLWALFLGGGIMFLPESPRYAYRMGREEEARNTIARLAGLAPDAPSVNFQIDEIREKLDEERQGAEAVWYEIFTAPKMLYRTILGITLQAGQQLTGANFFFYYGTTIFRATGLSDSYVTQIILGSVNVGCTIAGLWIVKVCRRRDALMAGALWMMMCFLVYSFVGHFKLDPINPANTPQAGNVLIVFSCLFIAAFATTWGPLVWTVVAELYPARHRAPAMAVATASNWLWNFLMSFFTRFITDAIGYLYGLVFAGCCFVLVLIVFFFMIESKDRTLEEIDTMYLLGVNPITSHKWDANSANLEKPNGNKGVEASPSTSGDEHPAGHEEKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1A0</accession>
    <name>A0AAE0U1A0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_469407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1A0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="132"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="368"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3387171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="500" mass="55515" checksum="12F6AC166B0C2906" modified="2024-05-29" version="1">MSDPRESSSYSVTPRIRYNTVGGVNGPLVILDNVKFPRYNEIVTITLPDGTQRSGQVFEGTTGIDVKKTRVEFTGESLKLGVSEDMLGRIFDGSGRAIDKGPKVLAEEYLDINGSPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVQRQGITNKGVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSLERTTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSAYCDALREVSAAREEVPGRRGFPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFIDRALHNRGIYPPINVLPSLSRLMKSAIGAKRTRNDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSPEDKLSLEFLEKFERTFISQGAYESRTIYESLDLAWSLLRIYRKDMLNRIPANILAEYFSRSAAQKEKRNAAENAATSTKGTRDTEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1X0</accession>
    <name>A0AAE0U1X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_470419</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1X0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="107"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3387580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="546" mass="60696" checksum="0891C23CA9CC1375" modified="2024-05-29" version="1">MSNGTAPNGDAPHPTHTPSQRYLSTRGEDADLSFEEVVLKGLATDGGLYIPEEIPETPQWQAWKDLPFIDLAYNVLSLYISPSEVPADDLKDIIRRSYSTFRAPEITPLVKLQGNVHLLELFHGPTFAFKDVALQFLGNLFEYFLVRKNEGKTGRDRYHLTVVGATSGDTGSAAIYGLRGKKDVSVFMLHPKGRVSPIQELQMTTVLDANVHNLAVTGNFDNCQDIVKALFADPDINSTLKLGAVNSINWARILAQIVYYFHSYFALARQSESFNVGDKVRFVVPSGNFGDVLAGYFAKQMGLPIDKLVIATNENDILDRFWKTGRYEKKATHGAAAEGGIESDGVKAHEDGVKETLSPAMDILVSSNFERLLWFLAYHFAGSAGMDDEWNKKQAGQEVSAWLKDLKTKGGFGPVYKDVLETARRDFDSERVTDQETLDTIKRLYKEADYILDPHSAVGVEAARRSVERAGDVPHIALSTAHPAKFAGAVTVALQDEPGFKFDEKVLPTEFVGLDQKEKRVKDVENDWKVVRGLVKKEVEEELSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U258</accession>
    <name>A0AAE0U258_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome-b5 reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_542317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U258"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="217"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3387850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50164" checksum="92DF6993B58C6AD8" modified="2024-05-29" version="1" fragment="single">MGSPLVEYTAAEIATHNSPSDSWLVIHGEVYDVSKYAHDHPGGIDVLLEAAGTDATQGYEDAGHSEDALEIMQTLRVGILKGYKKPAPKMRSQTLAPRLTPATTKSNASSSSATAVVQTAALTAVAAVSLAEARLFVQNILRASPMPTHTHTGTTGGFTSGFLAASAIASVLGGVAVKQLSKATHIKHGFAQFAPHKKSVRPPQPDVNALRGFLDPKTYQSLPLVRKDEVAPNVFRLLFALPTPQTVLGLPTGQHVAIRATVKGQVVTRSYTPVSMNVDQGVLELLIRCYPDGLLTGQYLAHLKVGDEVEFRGPRGSMRYWRGLASRIGMLAGGTGITPMFQLIRAICEDPRDTTQVSLVYANRSPADMLLREELEGLARRHPKNLQLWYMIDRKPEEGEWEYGVGYVTREVLEKRFPKASDEAKIMLCGPPGMVGAAKKMLAEMGFMTPGASPKMDDQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3F7</accession>
    <name>A0AAE0U3F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_507012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3F7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042048418" evidence="1">
        <location>
            <begin position="25"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="166"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="358"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3389421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="767" mass="80961" checksum="2E421A923798F124" modified="2024-05-29" version="1">MGLSRRRIAAILLFGIFSVYGVNAAPAPQAGAPNAVNPNACAAIASATNSLLAASPLATPTVAATLALECLQTVPNKIEPAQRLVKSLKAFVQWQSSLAFLRDPPQSYGFPAVDIQSGLDSISAKAAAGGFANEFDFQLAIVQLITSAHDGHFSFRPDVFKAFGFRNKFATDIVSISVDGVQVPKLYHYAELMANSTAGALPRSIILINGEDAATVIERRNLVFSGYQDRDSQWNAAMQSYALPTGTNFVAASLDFNGAALTIMYDTGETRTEDNFAIIRPGVNFTGISTGEDFYNRFCNPDTATVAAADATSTSPATPTVNAAPEPTINGYPFPFIRDSGANITSGYFLNGTGYDDVAVLAVSAFSAGGGISAVEYLTNFQDTVATFLAQSKLQNKKRLVIDVTANGGGFVVAGYELFAQIFPDAPDFQANNLRESDSLKLMAETSGRFLDQIINFNGNTDANSTDIGADAGASTQAQAFSILQQSSVVSNLVPGGVFTPDGGNLTSVAEILGPVTLKGDRFTAYQFTPLNMTNSDFNLTGTGSRSNPPPAVFAPEDVVLLTDGTCGSTCTIFSYLMILQLGVRTTVVGGRPQNGPMQSVGGVEGAQVFFFEDISAAASAVLVLSPADNVTDSEIALLDEGYALRRAANPARPGAVNGKNAFMRADAQTPLQFLYQPANCRFFYTKDMIYGPEEVWKRTVDATWTDPARFCVEGSRVEVNMSLAPTDARFSVNARLAGESAAAQGANSSLVFAVMLSALVVALLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U454</accession>
    <name>A0AAE0U454_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_111366</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="289"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="513"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="866"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1200"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1013"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="868"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3390323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1471" mass="161644" checksum="22623F586A970C5F" modified="2024-05-29" version="1">MPPPLAPASASASQGPAQQALKSSRRSSRRHSRRESSNSEAWTEEVGFLKGYQTMSEQVVGAGSSSMPVPYSPRDFAIEPNHADIEELEGTPRLGSSAVSHDEAQHRYLPEPAILSGRSSVSDAEAASHRVSTGSIYSLASVRGVPSSAASANGSDNNSITGSGPPHRAASGLIASSGGGTKGPATAQAEAGVSNMTVTTASHGSHQLAPRDSHAQHLNDMIKKPVQPQQAGVTATAAAPRPQPTRSRSRAKRRFSGSTAASSHSPSSDRAMTHRAEKEEVKPAPWGVIGVCALDVKARSKPSRNILNRLIQNREFDVCVFGDKVILDEDIENWPICDYLISFYSDGFPLEKAIAYVKARKPFCVNDVPMQKILWDRRLCLRLLDRIGVPTPQRIEVNRDGGPSLLTPEIAKHIKDVSGITFEPTDPDPANAKAMSPRKVELLDGGDILSVDGTLIKKPFVEKPTSGEDHNIVIYFPSSAGGGARKLFRKIGNKSSEYIEDLTVPRAITQPDESFIYERFMQVDNAEDVKAYTVGPTYCHAETRKSPVVDGVVRRNTHGKEVRYVTALSSDEKEIASKISTTFGQRVCGFDFLRAGGKSYVIDVNGWSFVKDNDDYYDHCATILKDMFIKERLRREGLTPSIPSPVPSDLDSMAARSIMANKDKDLSALVAAQARTSLDKQASALQKAPETRDSPVEAIAIVKSDGTLIPNPKLASLPASPLASQFSTSVADSVPSTAPSTISVTPSLLPDLLLASGEVQDEPPPPPPPKPSWKLKGVVSVIRHADRTPKQKYKFTFHTEPFIELLRGHQEEVLLIGEPALASVLEAVDVAMRAGIEDRGKLKSLRNVLVKKGGWAGTKVQIKPMFRNKSDAKKSEEKTATLKKENLKDGVEEAKADSSETTEKERTPRIPPRRQDSLSGVTMSKFTAAEESLVLDKLQLIVKWGGEPTHSARYQSQELGESMRSDLGLMNREVLEEVHVFSSSERRVVTSAQIWAASFLNKKDVPEDLITIRKDLLDDSNAAKDEMDKVKKKLKGLLRKGNERPPQFAWPPNMPEPAEVQTRVVQLMNFHRKVMQHNYSKLYSGAVNSLNAINNPSTDKVNIDGGSGASLSSLGSLGSLSQVNAVNSIQSRWCCGEDAELFKERWEKLFAEFCDAEKVDPSKISELYDTMKFDALHNRQFLEWVFTPPKTMLEEEYGVPANGKEGKQASPPSKSPEEGNTEPKVSEDSKSERSSSTVTVKPEKEGTKTAVKRIFRRRSFLHGLRPGSGADAELPEKYFHLHRGNSQTKAKTDARFEPLRELYQLAKVLFDFICPQEYGISDSEKLEIGLLTSLPLLKEIVQDLEDMQASEEAKCFIYFTKESHIYTLLNCILEGGLETKIKRATIPELDYLSQISFELYEMPANPPIDADGNPAFMYSIKITISPGCHVFDPLDVQLDSRHCIGCAPRRSLTAHADWMVVIETLRAKFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6H3</accession>
    <name>A0AAE0U6H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6H3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3392736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="541" mass="59020" checksum="399B817AE0B4758E" modified="2024-05-29" version="1">MQDHPSWRLLPVAVPGIPNLLVSTAFTAESYVVHLSDLANVWVEAMDRKPIVKRGLVEDTSIDPTDGPDQIRRMLELLRAAFDVDDPEHANTTLSLTKDSDDDSLALHVTCILPKPLKPFRWPMCFKKCLPSTLTTELVLPFVQAHEARAQEISSLIAALREKDSVITRLVDKLEATGMGLEHVFSSLSGKRKVSRATAEAKIKGLAPFVEADFRNTSAEKQYTAGPADMPALLSSVFGVTGGLKYKTDLDLEASTSLNNWWTKLSQGKQLMLVDRPKEEITKDPLPPKSTEPKGDGDDDDDDFQVQATPPRLSAARKRDIDTRPQTIDDDETSDGEDAPDALESVPLPLKTVVTGKPSNSRIGAIGRHKKPSSSPPRQVAPPPAKPTKRHSYGDDSDTASDTASEILSVGSKASPPPSSHKALQRRGGLGRIGGKAKEMTLEAEPHRCPSPAGSKGQLSPIPTRHRLGVIGKKAPSQTIDTRAESTSDDERGRSKTPAATQSKERPRETSQERADRKRAELQRDLEWKAAAGPAKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6T0</accession>
    <name>A0AAE0U6T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_386383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6T0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="66"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="462" mass="49447" checksum="2B77A4AEB805C05B" modified="2024-05-29" version="1">MGISTLLHQQPQQPPTAASVTIPVTNGRVPIPARGVDYRGKVVLAPMVRSGELPSRLMALHYGADLVWSPETVDHSMIGTTRKVNPRTGMIEWTRLSNNASKRGESAEAESVIFRVDPVREAGRLIFQIGTSDPARAVTAAKMVAHDVAGIDVNAGCPKPFSTSGGMGAALLRTPEKLASILEALVQEVTPAAQVGISVKIRLLETATETEALVRRLVRTGITGLTIHCRTTDMRPRERAIRGQLRMIREVCHEAGVACLMNGDVENRDHAAKLMDDFGVDGAMIATAAEKNPSCFRSAAEIGQPLAPWAETVEKYLAYAIETENKLSNTKFMLSQMIPGKSPVYREMQPWKSYTALVEGFKFAGLVEKAAEADRVLALPHATPAKAMPPANNNTTGDSKKRKRQQGDGDNNGRPASRGRKSTAAEPLLIAEDPFAPSATATVTAPATAEAPPPQVAAAVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U792</accession>
    <name>A0AAE0U792_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_387996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U792"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3393160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="131" mass="15125" checksum="2E974C21A9CA6A84" modified="2024-05-29" version="1">MSSEQASAGSSTNVKVPPPEPNALANEPKYAGSTRFELELEFVSMLANPKYLNHLASRKFFEKPEFIAYLKYLQYWTRPPYLKYLQWPGPTLKHLELLQQEKFRQDIISPDLVQALIAEGMKTGVEWHRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U848</accession>
    <name>A0AAE0U848_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_35773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U848"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042182031" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3394105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="354" mass="38921" checksum="663E345C98267159" modified="2024-05-29" version="1">MLLKPLTIAAGLLAAPAAAFLIPTTVSESDIHIANGIDVIAPEIAENRVVKLDCPGCPIVVQGSVKSDKSNHLELAFTIEHQLDFDRLLLNGFELYPHADPFHDILAAPQILDRRSNKHDKSTVPAHHKGPHHRRPVLPLGFGLQVHPATKDAEGVLELVSIDLQIIEVGAVFVDSIPNVEVKLIKAPGNKLLIGNIVTGTPQTAVDKQKECTTLMCKWLAIVQDRIKSLKAHRPCHGNKPAPVNGEKPKWQKIHHEHSWRMLFKNIASHILLPVLIGIVAGVSVSLIGMVVGTLIVSLWRTFFRRRSPHHHRRSHSHHKAAPKEAVVEEEKSGLMSNQAAPPAYEDDDVKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8C3</accession>
    <name>A0AAE0U8C3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_40258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8C3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="376" mass="42123" checksum="1918E7D5EEFB8E4F" modified="2024-05-29" version="1">MAEKPSVLIIGGLGYIGRFLALHIHQNELASEVRIVDKALPQLAWLAPEFDEACAGSKFVQADASREQALARIFDRADGKQWDFVFNCGGETRYSQEDEVYKLRSLGLSLAVGKEAAKRGVKCFVELSTGMVYKPDSSPSKEQDKLKPWSKIGVFKLQAEEELAKIEGLNLVIVRLAHVYGPYASQWVATALCMARVYKALESDMKWLWTKDLRTNTVHIQDVTRALWAITGWYTTGKKANWDEKTMGKVPTFNVVDKGVTTQGAMANIIGQVFGIETSFQGQVISMFAKLNLESVVDDVNDELLGPWADLLSEAGITRPGPLSPFMEKELLKDTDLSMDGSRLEKIVGFKYEKPQISKELVEEVIESYKKMNWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8S6</accession>
    <name>A0AAE0U8S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B0H63DRAFT_461887</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8S6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="889"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK3394765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="986" mass="111018" checksum="B7B7935351EBE3B2" modified="2024-05-29" version="1">MASLKRSIERDPLAANISSKVYVRSTKSGKVQKIVREVYLRQDIPCSSKLCRSCLTTAPKDAAGRTIPFVLSEDPAGTSAFPQGHYLVPDTNALLSAMDLFEQSSAFYDVVILQIVLEELRNRSLPLYNRLIGLTKSEDKRFYVFFNEFRLETHVARGDGESVNDRNDRAVRKAVAWYAEHLGRIKGKKAPAIVMLSNDRDNLRKARQEGLHACSLGGYVKQLKDGDRLLDMIPDTEDREIVKDKRPGDNLYPEYFTISKMMTGVKSGLLHQGIFGVSPYNYLEGSIRVPAFPKALLVLGRENINRAVDGDLVVIEVLPKDQWKEPSTQVIEEEAVTKNENPDTEASEDFISEKERKALQEDVKRTHSKTTEGHAQPTARVVGVAKRNWRQYVGHIDQSSISQSGQQGRKQDSVFVIPMDKKIPKIRLRTRQVAELLGKRILVTIDSWDRSSRHPSGHFVRSLGELETKAAETEALLLEYDVQYRPFPKTVLDCLPKEGHDWKVPASLEDPGWKDREDLRGLLICSIDPIGCQDIDDALHCKPLPNGNLEVGVHIADVSHFVKPGNAMDTEASIRGTTVYLVDKRIDMLPMLLGTDLCSLKPYVERYAFSVLWEMTPDANIVNSRFTKSVIKSREAFSYEQAQLRVDDVSQQDELTLSIRSLLALSRKLKQKRMDAGALSLSSPEVKVQMESETSDPIDVKTKEHLDTMSLVEEFMLLANTSVAAKIYDAFPQTAILRRHAAPPKTNFDELSNQLRVKRGLELSVESSRALADSLDACVDPKEPFFNTLIRVMATRCMMSAEYFCSGTQAYPEFRHYGLASEIYTHFTSPIRRYADLVAHRQLAAAIEYEAVHPSVRSRGRLEAVCKNINVRHRNAQLAGRASIAYYVGQALRGKATEEDGFVMKVFSNGFVVLVPRFGIESLIRLRDLAEQEPQATYDAETYTLTAEGSREIKVELFQKVRVKVTDQKDETTGKRGVKMELVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U8Z8</accession>
    <name>A0AAE0U8Z8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_462513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U8Z8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="258" mass="27811" checksum="C001B157029F2D14" modified="2024-05-29" version="1">MSQSPRPTIVLVPGAWYPVATYDKVAALLQAQDYKTVQVSLPSSASGDRNASFPDDIHAVRSAIFDETSQGHDVVVVAHSYGGLPAHSVLDGFPTAEKDGHVIGYAMLASGFTQTGMSFLDGLGGTPPPTWRVDEETGFVVILAEPRELFFHDLPEEEGKYWVSQLGKQSVKSLVEGGDHAYAGWKDVPVWYLASTEDKALPVQAQRMFVQMAKDAGGDVTLREVESSHSMMLSKPKETADFIMEAAAAFVAYKAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K0M2</accession>
    <name>A0AAE0K0M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_515602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K0M2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3367853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="919" mass="102584" checksum="A01EDAC5EED8183E" modified="2024-05-29" version="1">MTAATLGELPRHLVILVFVLTCATTTFNAEFLSHSTALSSLSGWQDRKIKTWPSPELSVGRYIGKVGKVSCWEAKGPARTAFNEVAPEIKKYLDRSVEPISSWVTWSMYMFGKAPKNANPTIVFCCDVVAHRKQVRKVIKESGLLDAYHGIKTGHMPRAPDYEQLVRLANLPDTEPARITCPWVASPEGMSVFTTSVTGKQSKATIGGVIRIRDKFYYTTAAHAFYQQAILEAPLKDDDGDDDCHFDDDEIDIDGCSDTSEDQESEENEYEQHLTPTSDIASKDIPAPPPYSAHDLGPVVASSMDEPRSDLDYALIEVTDPSHQRLNQFDSPNLSSETQLAVQSVSSLKIRDAKVLSATSRGILTGNMSGTPVYSRAPGGIQSQMVFAVQFDLPLEVGDCGCWVVDAETGELYGHIIAGSPTSGRALAVPFSAIFTEIEWRLGFRPTLPLCGTQSPGKRPDVHHSRTKDTTFPPAGSINWAREFRRQLEERLLCARRFQVTTPAATLDCRLSRAAAAISSGNNNNSSRPPTTTTEAITPTPPAGNDRTSLKFRKLLFSLSNTPLKWENPGLLDEALRSVPMERIYGEAEEEHQVFQAEAESMGDGRCAKWGHEDCVVRALLRWFKRCFFTWVNNPRCSTCFNQSTISTGIVEPSPEERACGALRVELYWCPPSSDRGSESGGCGKYERFPRYTDVWKLMETRRGRAGEWANCFGMLCRAVGAKTRWVWCAEDHVWTGVWSRQQRRWVHVDVCEEAWDKPRLYAEGEFSPAHGLCNYQDGDKANGDNELEWGKRMSYCIAFSTIGATDVTGRYVQDPRHARERTRCSESVLLYILREIKALRRRDFDSAQRYRLDYRDLSEQRELRNYIVARIVDRLCKSVGWAMQTHTSPGKTCNVQDAEENKEGGGGGSITVFTGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K136</accession>
    <name>A0AAE0K136_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_68951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K136"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3368093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="181" mass="20318" checksum="2A4A72762C585BED" modified="2024-05-29" version="1">MRSDLESREENTRSYPHLAIALNFKQKQRETLIKWHKGTGKWLLDSPSFQKGVVGEPNSTLRCPGNAGAGKTVMVSAIIRHLDENTQKPQDAIAFVYCGSEVPETTSEVGILSSISRQLAQQCRHLPVELRALYERQQELSAFRSEAELVSLVENLAKNFEKTCPSPLTMMLIVTEFLITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K163</accession>
    <name>A0AAE0K163_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_535858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K163"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3367760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="336" mass="36137" checksum="AF91D20B185697A4" modified="2024-05-29" version="1">MGSHDAPNHVSPGAFLAAIIIPIVLPAFFVAIRIMNTLSIRKDLYVDDWFSVLGLLFLVVIAFSDPTMSVELIGRFTVAVGFIASFGAYFAKVPILVLYLRIFGVYRWMRLACYGLLTAPFFVLSGSASYSAVMCAPDRRVLDSTFSVGCMRAGLGTCVWNGSIALVADVVIFILPLPAISILRLPTRKKVGLYLVFLSGILGIAASAVALYYRSISLASFGSASTMVGEVLGPVIECSIAIMVGCVPALSCFWQKRIVNLALYSKIRSAFSSTESKESQTTTPDAKVVSNASTGYSFDARAPPPMYPDLGDTKGPDAYVVARPKEVHYYQGSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K1X5</accession>
    <name>A0AAE0K1X5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_403914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000010">
        <property type="protein sequence ID" value="KAK3368065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K1X5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3368065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="557" mass="60592" checksum="A4EAD38C4F23FEBB" modified="2024-05-29" version="1">MVYCGKASQGCQSCRGRRIKCDKVLPQCTQCIRVGKICPGYRDQLSLMFRDESTKVIRKAHAQWGASEAGESSGSSPTSASTGASPASSQSSQSLTPPSGSQSSPTSLHKEIGGTKVDRAIQFYIEHYVIGLPDEPQVGQELRGKSWVHTPETRGIMAAVGLASLSNLTGDKEMQTLANQQYGVALRTIVNSLKNIQGLDLEVSLRAVVNLALFEVVRVQPQVVNPARTHIMGAAALLASLIPISKSPKESLRAQLQLCFSMLGSIQCSLQLHSPEPNVLIPQTSTNSAAPGDEGILPAIFLNWVATSESRATAPDSPSAKLLGIATRLVQLLASVRSHVLFDGRSGTAAMILDALQLNTQLDAWEQGQDGIWNVIEGHADDGFFPPEAVFEGHYHVYSNMWTARVWSHYRCARLSVDQLLLEAVKRYPICGQSLVSAGKQQNLLDCINRLARDTLISIPNHYRHPRLARMHRDYFDKTKGGAGIGAAGIPTLAYHIKTAGSAPGVPLRYRAWALGILDTMWADTGMFHVKALADNLSRIYQEHLQKDDSREILKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K4M0</accession>
    <name>A0AAE0K4M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_454207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K4M0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3369984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="355" mass="40071" checksum="CB1D81A21C6568FC" modified="2024-05-29" version="1">MERAKQDGQARLLVINEHIRRVIRHFFEEFSELVVLDEHSGGFIYCIIEELFECSVMAQTSQSGSLSSIAKGSDVGFMSTKPSLQAQLDFDPKHYLRLRSVIYPGQTPSLDSLAFLKEYFYSTMFRQQLETLPQRPRTPRQNSWDSTTSTLCELEAPNVFLLGHAPKIAQDPLDGIDLPPVAVPPIDLPAFDFPPREALVPLPLDLAGVQQARDHKPTGGLRRSPPFSMSCELCQFYPARGTDQRKKMAKHLLTNKHRVAAGHEWDSGDMFQCRLRSRDGSVCLREFNRRDNFRQHCKKVHGSSSEASEVGDGQSARPWDGLPELPGNGVQRVSSTHHPHPKRRRTILGRAPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5I7</accession>
    <name>A0AAE0K5I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_306161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3370045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5I7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3370045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="236" mass="25621" checksum="07E0000DC8901618" modified="2024-05-29" version="1">MVSRNYCHPGYISKRAIPPSTVQPQLIRDASTSSRMKKEQQQRATRAVRQHNKAFDGPGVAGCIVGYGITETAPRMCLELTTMLPCGHGSIRKEIISCGNGSASGGGKRRSSGNRKESSTSVSTGIERSGSSARASKSKSSPSSKNTSCPGLRQETIQADPAVSPRCPLPDCAYEEKRRCWECCSCGKGWNMTGRCIAVHIWESDPVPCEHVCCEGCKESRHHDPLESWEQGGYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K5N3</accession>
    <name>A0AAE0K5N3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_497134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000009">
        <property type="protein sequence ID" value="KAK3369871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K5N3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="16"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3369871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="397" mass="45098" checksum="6ACC186AC0C54ACE" modified="2024-05-29" version="1">MDVDDDDEWEYEYSETEIETYYLTLDLSVRDFLERRTDDIIHNTRGGYRVWYNPLFNAPEPRATNPELIEDKDADDGELPEREEPDLDTIGMPQPETRTELPIDPLLQQPADKTAPMTSEANNAPADEIQILELHSAEPIVSYRNHIFRGTWAENIGTEMIFTPHDDKAPLPALRNLGHEIDLLAASAARINFKEATLVPRNDSGGVGVHGLDNHVSRDTFERDEDIPERYKRNGGIYVHIGGDKSGQRQPQAHFLEDLISLKRKRGEEDEVTIQSLETRQNRLMMEDEEEERRRSKLQADYNRMIISRQRKRGGGGAQAVPEESYIPRLGPKPAKGRRGGGPGSRPRTRRAVLIRREDNKAGGIGHDLSPGRTLESTPTPARWDDLLKKKNQEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K8Y6</accession>
    <name>A0AAE0K8Y6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_496834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K8Y6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="511" mass="59333" checksum="B832CE90E39697DA" modified="2024-05-29" version="1">MSLPSKPDTPELPPEKPLIPASALDWEAKKDLVFKYYMQQNLILNDVIEIMQRKHNFKATARMYKGMFQKWAWTKYNKSSKNNVDKVVAPKSQKRKSVSDGIAPYQYHHHTHPYHGYHVSKPAPATYHHPHPPSMNLIRMMRFPDEESFYMESTLNQYNIYISTWVRRDAPWTSGFHRSSILQDFRTAKDHFTQEHPVEGGECIQRAFNKIQEVVSAELDIEAIWDCCLAVPQLALSTNWTDILLIYTEFLYKITALKQPNHPISKIAKNLHRLASNDPGNNLPAIQKYIESGWKLWINLVSDLRGKQDRVTIHLKRGYVILMNPEQSIVGTLIDDFNASVQKSLEKEGEANTTNHILELEQLLVRMYIPLFSTESTWRARTFLTGILDRIKAKRSVPRITEIDDAEQQDETTLTFLPSPDWDYLDRYLFFSVHNFLAAIADSIGEYENAADLRRKSLESPRDRFWVQTAENLEEYLKSEGRHEEANEIQRQRYEVVPAMGDLVRLGSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9B4</accession>
    <name>A0AAE0K9B4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B0H63DRAFT_300779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9B4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="139"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="261"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK3372543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="405" mass="44170" checksum="DB9B289601FA80BB" modified="2024-05-29" version="1">MAPNGVNGTNGDANGVSGWKHYNEGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMVMVFGEISTKAKIDYQKVVRNAIKDIGYDDSSKGFDYKTLNLLVAIEEQSPDIAQGLKLDERLENLGAGDQGIMFGYATDETPELFPLTLLFAHQLNAAMSRARRDGSLPWLRPDTKTQVTIEYKHDNGAVIPLRVDTVVVSAQHSESITTELLRKEILEKIIKTTIPAKYLDEKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYLGRWIAKSLVNAGLARRALVQLSYAIGVAEPLSIYVDTYGTSEKNSDELVEIIRANFDMRPGVIVKELDLAKPIYFQTAKNGHFGTNQSFSWEKPKTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9B6</accession>
    <name>A0AAE0K9B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_550267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3371927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9B6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3371927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="448" mass="48623" checksum="742386D40A89DEFD" modified="2024-05-29" version="1">MGASQPSCLAVLHSPLIEIDGRTGEGGGQLVRIACALAAVMTVPIRITNVRGNRGDGPRGGGLKSQHVSSIQWLAKATDADVDGLSVGSHTLEFRPRLKPSQLKKRRIRISADSAAASTLLIFQAVFPFLLFAGTTGDRNAAYAADPIELEISGGTNVSFSLSFEYLDQVLLPTLEDAFVGIRVERQLKARGWSQGKASRGTISFKIHPLRLGETLKPRNETPSFLAEDFEVTEVDVNMIVPSDMHEELPKSLAVDLEDLFPGVEVTFKLIEDSGADSRVYVLLVARSKTLRWGRDILASTPKTSSLKTAKKARDKTAGASDVSKTAFSADVSRQITKDLYEEVSTGGVVDRYLHDQLVVFQALAEGSTSFPRCNDNDEYDGGLDGAMEALDISEESLHEDRMSAPFGEGSLHTTTARWVTAELLPEVAWFNKGRVCQGIGMHMDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9M1</accession>
    <name>A0AAE0K9M1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_564056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9M1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042005051" description="Fe2OG dioxygenase domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3372678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="263" mass="29100" checksum="12319088E06C8521" modified="2024-05-29" version="1">MILFSLPITAAFLGGGGGGAVDTVVGGYACIHPTYRVHKVSSSPLVIYLQNFITADERAHLKKVSESSFRRSVVAGHDGAQQSRIRMSQSTDLRRDAVVKCIERRALDFQGFDTHETQLEPLQLVKYGPGEHYDFHTDWLADPQYSTSFNGGNRMTSFFAYVHVSNDTTGGGTNFPLVSPPRDERWCGFVECDEPYANGVTFRPVEGNAIFWENLLAPGGEGDTRTEHAGLPLTGGEKIGMNIWTRQVPLSDEVRREDLPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0K9W2</accession>
    <name>A0AAE0K9W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_483912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0K9W2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3372125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="18744" checksum="6EF17ACFE66321B6" modified="2024-05-29" version="1">MGISKSTFGTGTVLFTTLLAALFSARFPLCWTSVSQFVSHFVSRTVCHLVRRPIAHVVFHHVDHSVAQLVGHLVGLPVSNPVSRLVVHLVFRLVGRPVTYLVSHAVAHAVAHVVTHLAFHLLFHPVAHPLAHLVARPAAQPRASSIAQPIEQPIANVWSPDTWAPGAVACGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDE9</accession>
    <name>A0AAE0KDE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_399750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDE9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="488" mass="54681" checksum="0AC159DCB4AAFEA5" modified="2024-05-29" version="1">MLMHLIGNPINTIASLLATIHGCQGWVNLLRKRMERLAQNNPKYSPRTRRRAGTLWKPFALLCVSYEEWGVRNWEAFLLNSLDQLLLTPNPEVMEHFEEAASLLAADRSTYALPIFSAQFAFIFAIGAAYWRVIGVKPQPHSWTNVEAYSIAMSAPFLYTVPAVFLSAVVGVAQTETSIPQILNSLRDKLINDGWDAILAERYKEGNNMVDVIPLPANNARHEDDDGAVVEESPEAPATLFQRITSGGLYSWRPGMLATGNLHETWPHIALATSFVVFSVFVAGWISYRVPPEGFDCRNAAQMSLLGVWLLNFSLDFFLTLAMDKLYHLLHAGAGGRRKSWYWYEIMFAKDLIMALAAFTLIMVTQLGIFNRCDCYTLWGTVPLALPQIREVAAVLMDRISFEWPLVTFLWIGIELVLCVAIWGRYSEAFRVYMQKDDRTSNLDWAPGWVRRLFKGKGGGGVEVEMEVIQGFPGGVRRGGGTTRGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KDL6</accession>
    <name>A0AAE0KDL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_548822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KDL6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3374584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="338" mass="38163" checksum="403BC66801FA068B" modified="2024-05-29" version="1">MANSFDQPPPNTILPKLGLPLAIILGIALTAGTTYLVARHVIKLRAKATVDSNPATWKLKARQRVYDACYPGCNGDILADGVECSANKIWNWAERYPDICLAALGETYRVKDLEEERRKPLGRIALVILTVLVGVLDGSAVSWGWKRATARCARYEEATRERARQWPRMRDAAPWRITRRSRNPSNTASTSKRAKLKTLLAGLLASSRGAHAGEYFCNMVLLTNANETITAAVHGWTSVCVNWQECWTVPSWECDPLWNPLKDREQCQWYNREKCEWHWKVKSSPKDRVDGIMGSVKACGFHEVDTLKVPAKLRVAHPGIEKHSFVTIKAYQYPFLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KJY9</accession>
    <name>A0AAE0KJY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_512028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KJY9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="12">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="323"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3377853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="349" mass="36931" checksum="C36C8363E79C47EB" modified="2024-05-29" version="1">MSPISIDFRDDFDPAPSSSSFSNGPSSSQSQSRTLLLAPPSIASREERISSLFSTFSRSTTDLQMLDRLAAGLVTLPAARYDLVLVLTDSDGSRHAEATAFLSGRDVWAHLVPAIKAGGKLRSEDRSLGKNSNTVGAEAAAAAREAVLAGLVSAADGFTKPDYAEEEVVPLRFGLKKKANGTAAAVIPAPAPAPIAPVVSAPSGVGFVDFSDDLDDLDDDDDDDDALIDEDTLLTEEDLRRPVPLAPECQPKPGKKRRACKDCTCGLAQKLEAEDKARREKADKNLNTLKLTSGDLNELELDLTVPGKTGSCGNCALGDAFRCDGCPYVGLPPFKLGEEVMILNNVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KK75</accession>
    <name>A0AAE0KK75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_224905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3377755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1431" mass="155613" checksum="BFAFAE30021DEBC6" modified="2024-05-29" version="1">MPRATTKTSKSKRRKRAPVPKQTTDVLFLIRGIIDEKTVKGRLLYKIDWEDNPTSGEHYEPTWEPAENANETAVADWEEVKRRRQTSSVSSSEHSSVDQSNSRKRQRSTASADKDSRKKQKSSKTTPAIDDEASKATPARDDEASKKTLTRDDEPEIEPGPEPEPEPDWAFAQSEPNKQGTLVLDIKQRAGFDASEYSRIQLSQSQPSQLSQASASGGESAHPTEENGKASQTTIQDSQVFTEPLPSDLTPSAPSPRENQPLGSDFAAAAGSVVISETAQGSTQEDASQFSPQVEDGSIKGLPQNHEGILRSREDSGEGHGGILQSFGGDINSSEEFGRRSQSTHPEGPSSSSDPNIPSGQPETGLRQGLNGSFSLLEGQQGSAEHSSTNTLPGFEIASSQHSGFLTQPDFHSAFSPEDSSATRIVESAINSESLQQLGESSGRSIDTHSRANRLNKATTSPSPWSPHFAEVVLPLSSIPNPFLAQSHHSTDIKEIVLDTVEKQARKEFSPYQLTQALGQLTNRSQAFTSGLQTSGSSSRLLRHKLSPLRTRGNPNRCRPSTPQSASMDTSSVEGTPKTRSAVEEFRALRASVFDQNRDPTPPSPTSFSTSWHATSSNAAVRNLDTGAGPSTLHKEGSLSAAEEIKRAIGLGLGDVSSSGLSILPDRRDSMTKQHIGTDQGQSADVSRFGLGLPADHTAVGGQYVTLDQGRRVDSSAAGLNLSSGHLNPLFGEHMSYKSVPTTVAPSDLTISFNHATSADGALPSDGQNTTVNPMSTVLINTESEIHDDLEEDKSSHHVFNEHIVTLPMAASTRNEYLSIIKENKATMIEFSDVFINLDSMPSDALTSKMDMVFQRLLDLCDLPASADRLHGMAHREMMRHATNSNCKYSFVHEFLKGIRDLNARALILSQEGHPFQYLEAVVSESGLRYTVLGQNKEPIDHIADGLTVILAVSDQDLTSIHGGIDVVVAFDHTARSITLPSTLASNDKPALVLSLLASYSLEHIDFQLGADVVGLERKNALNTATANMKPLLKNPESGQLEPYEAADFFASCMRHPQDDIHWVPLHLCDDVMDFWQSSQSRTHDSQSLTFHDSNGLTSRKRANDDTEGGALKRPRIVDVSQRARNEPPVRMSDLLTTILSSYASPGKIPSQSVEVSVEQLEKMAAKIATLEDRLRAQDSVEARDRGTFQAESTKAKRVADKVTKQLEAKTSELESLKDQIRALQSKPTDPNTALATNSADSEAGGLATLQKSREETQAKANSLEKKLGIAQKELEYTREVYQIASKSFTELQTENQELKTKMGGLEKKAGDNLLKIHQLNSQTEAEAIQKRVDEFQAIIRDLQRDLDRARDELRHYKSGRRETRQASVPRSPRTGVLSPRPSRAVASSTGSRGTSPAPVDGNAAGSTGVPGMTFFSQPPGNNGRWGHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KKA8</accession>
    <name>A0AAE0KKA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_242073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2690"/>
            <end position="3245"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3518"/>
            <end position="3863"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3860"/>
            <end position="3892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2043"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3254"/>
            <end position="3322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3650"/>
            <end position="3669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3378249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3892" mass="442832" checksum="DF5A5F57FA801AF8" modified="2024-05-29" version="1">MASSLIEDVVRKLSTPETELRLKVEAAVTLRDSLDHYITGPTYTVFLKRLMPTFINILRQPCVFQTNTPEQANLQKLRNCVLEILHRLPTTPNPVEPFEPYAEEVTDLLMGLVKTDNEDNAVLCVKIIGDIMRHQHKVLQNKVQSYLGLIQELFEQMERVVREQLDNTASVGVPGTLGAPSTPSSTQTTFAPHQQSPRPGSPIAPGAPDFGTDASQQSGRPLLRGMQSFKVLSECPIIVVSIFQVYRGCVAANVKLFIPLIKSVLCCQAKAQEQAHKDAAARGTIHTGVSANIKNRVVFGEFVTAQVKVMSFLAYLLRQYSQQLTDFLLSLPDIVVRLLKDCPREKSSARKELLVAIRHIINFNYRRIFLPKIDELLDERTLIGDGLTVYETMRPLAYSMLADLIHHVREMLSPEQIRKTVEVYTRNLQDNFPGTSFQTMSAKLLLNMAECIARMPNKVDARHYLMMILNAIGDKFAAMNRQYPNAVKLKAMYERQGTESITETYLADKDHPPEYDEVDIFTAMPIKTSNPRDRAADPVVDNKFLFKNLMNGLKNTFYQLKSCNPTPVTDLANAPAHWTDVAYGFTAEEVQVIVKLFREGAYVFRYYEIEKPASESPYSSTVEYMANFYMISSSKEEKELLETFATVFHCIDPATFHEVFQQEIPRLYDMIHEHTGLLHIPQFFLASEATSPSFCGMLLRFLMERIEDVGSANIKKSSILLRLFKLAFMAVTLFASQNEQVLLPHVVDIVTKSIELSTKAEEPMNYFLLLRSLFRSIGGGKFEHLYKQILPLLEMLLDVLNNLLMAARKSAERDLYVELCLTVPARLSNLLPHLSFLMRPLVVALRAGTELVGQGLRTLELCVDNLTADYLDPIMAPVIDELMTALFDHLKPHPYSHFHAHTTLRILGKLGGRNRKFMTDALPVTFQNYVDDRAGFDVRLIGSKKDRPFPAHLGIDLAIQKLMEVPKPLKGTSTGSSKQQDAFYKRQALNLIKAQVKLRVGFDSLPDDLPRFVRLQAQDLVSRNKDVNISVFETYDRERSIAKRDDEEATLKRLIKALMFAQSIPEFKPEADAFLTGLARHFTIIEVGRTYVDMKRSSGPFNVTSGEGPLAIDTRVLSDAILESLASENPEVREGAETLIKEIYNSAVTIFGSPSHVSRLLFFNNLASTFCHGCYEEEWFTKTGGTLGIKILLTDTDLGDAWVAAKQIELVRALMYVIKDMPQDLPEKTRRSAQITLEILLKRLTSNVKKEDCMPVQPPAQPQPQPGQQGPKQSRLAQICVMLNSELSHMNRHVRDTAKRSLELIAKAAGAEIWELLEPHRKHLLQPIYAKPLRALPFAIQIGFIDAVTYYMSLKPDFVAFDEHLNRLLMESLALADASDESLAGKTLEFRTQDFIVNLRVSCIKILSTAMGFDEFQKGQVNPTRSKIVSVFFKCLYSDSQPTIEAANDALKGVLSHTSKLPKDLLQSGLRPVLASLQDAKRLTVHGLENLARLLRLLTTYFKVEIGSRLLDHISVIAEPNLLQQISFTFFEQHSTMKVIAAVFNIFHLLPEAAKQFKERVIDNVLELEEKLRRTHHSPFRAPLYKYLNRYPPDIWSLLLGKIDEPKYGRFLAQVLRHPDSQALRDYGVSDVEAIIKACNGVIGQGKDTKFSAIVNAINILDALCEFPNALTWMDNKEHIDWLKQVGKELERNLKMNALPPSLRLAADQACEQLMKILTKALERNPRDLEPLFSLVEAVTAEDFRETHALLAYMYKHIISSDSIDFWKTVVLRCLEIYAGRSASQRTKWYLLHNIVNPIVAMDVMRHWTRGEPPRGPRFFDKTIIDSINTKIWKVNLADPHEDLLQPRIDHTRMEVLQLSAMLVKYHHAILQDARKDFIKFGWTYIRLDDVINKHAAYVVIGYFIAHYETPAKIVSQIYFSLLKTNQNEGRALVTQALELMAPVMPKRCNSSPGDRNPVWAVAPRRILAEESQNVQQMTSIFHFLVRHPDLFYDSRDKFAMLIITCLRKVASPPNPSNESKKLALNMMWLIWKWEQRRVEGKRTEQIREISESPNSKKRRLDEQQSMSPAAPRQPDRPDFQIPPQGRQKMVKYLVEFIAAQLNERYELPSAKARDHPLASTGPTPPSPSTELCKKAMTLLYNLLQPQYWGDLDVDLFPNVTEIVLASDKAAGILAADPTDKEKYDDKFVTNIINTLQVVRIIINFKSDEWVIKNVPQIQKILEKVLKSENPELQDCLHVADKSYDGGREIRPIVKRILDTVPEDVPMEDADADTEAEAPMSEIVAFLSGIATESMAAANYVSGINILWSLGRRKPTTIDQHIPAIMKSLQTKLARDHVSHYAALAQAAANGARPPQDPGAPAEMDAYDLEIQTSLILKAVEITAMRMEILGDNRRPFLSVLATLVEKSLHVDLCEKILDMVETWVFRSEGTWPTLKEKTAVLHKMITFEHRHDPAMLMKFLDLVIRIYEDPKITRTELTVRMEHAFLIGTRAQDVEMRNRFMNIFDKSLSKAASARLAYVIISQNWDTLADSYWLSQAAHLLLSGIDMNPLVQLRQDDFRVQPVSQLFGSYAKDAREPSQMADDKFESFMSNHRRFVAEIGDVRVRDILEPLTQLQHIDPTFANELWTVLFPLFWSATAREERAELERGIVTLVTKDYHARQMDKRPNVVQSLLAGAAKSWPQCKIPPHVLKFEAKAYDAWYTALFQLENAAIKPEIDSAAVRESNLDALVDLYASLGEEDLFYGTWRRRCQFVETNAALSYEQNGMWDKAQRMYEAAQIKARTGVIPFSEGEYMLWEDQWVICAQKLQQWEILQDFAKHENLQDLLLECAWRNTEYWQTQENRDQLDTLIKGVMDAPTPRRSFFQAFMSLLKLHNKQETAQDFNRVVDEAIQLSIRKWHQLPRRLTAAHIPVLQNFQQLVELHDASVMCQSLGGTTQNNLDVKSGELKLLLGSWRDRLPNTWDDIVAWQDLVTWRQHIFGLINGTYLQLLPPQGQNAGGASFAYRGYHETAWIINRFAHVARKHSLPEVCINQLSRIYTLPNIEIQEAFLKLREQAKCHYQNPDELNSGLDVINNTNLNYFSAPQKAEFYTLKGMFLEKLKQKDEADAAYGTALYFDITAAKAWAEWGYFNDRKFKDDPTDLSAAKQALTSYLQAASSYKNHKSRKLIARILWLLSLDDANGTIASGFDDFKGDIHIWYWITFIPQLLPGLGHKEAPRLQSILLKIAKSYPQALYFQLRTSREDMLTIKKNQEAKDRMKQRAQNPGGKPTGSPQQFKQDAGAKADGSGSSRPATANGDGAGQVKPEVKAEGNDAPGSGVAAPAAVNGAVQGDQSGAMQKKPPWELTEEIMSVLKTAFPLLALSMETMVDQIQKHFKCPPDEDAYRLIVALLNDALAYVSRMPLSYAKDVKLPSATETNITRFAETILPSHIRGTFEADFVKVKPTMHEYIHKLRKWRDKFEEKLDRRPAHVPLEGYAHYSPHLSEFRYQKFDDVEIPGQYLQHKDKNQDFIRIERFLPNVDLVRTIGVSHRRLKIRGHDGSVHSFAVQHPAPRYCRREERILQLFRQLNQTLSSKKESRRRDLQFTLPLMLPLAPHIRIVQEDTSYITLQGIYEDHCRRNGMSKDEPVLFTMDKLRGLMETKGPVSDAPILPRRIAPPNDEPQKQPEHAVTARLEVLTAIQEKWVGHTIALEYFQAAFPDFAEFWLFRRRFSYQLAALTFMTYVLHIDKRYPQKFNIARGSGNIWGSELVSFLAQNKPLFHNQEPVPFRLTPNLQTLMGPLATEGIFGCSIMAIARCLTEPEFKLEHAITLFVRDEMMFWYTSSHRSLNLTENLLRDTVQANSEMIVKKAVSLAQAPAGNLPAHQTVIDLIAKAVNPSQLALCDALWMPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KL56</accession>
    <name>A0AAE0KL56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_249191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KL56"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3378499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34276" checksum="1EDAC2368EDDFED0" modified="2024-05-29" version="1">MGWLASFSGFLTPAFLVMSPLLSYTDQAYSMYTNKSSAGFSLDIPLIMLVASFFRIFYYPGARFDTALLVQSFVMVFIQVILLKIALDHRPAPASKGGEAALPFARAKEGLWEAPRPYGFWQWRSSKPYWQFILFLFMGLTLAEVVLGPFSSVYPAYSTLIGYIGLSIEATLPLPQIFANSRSRSCKGFRVSVLASWLAGDAMKMFWFFTSTSQIPLAFKICGIFQACCDSFLGVQYWMYGDVSDVGGADMSMMMKKDSKNSFPLADWQPASSDHHHHSIGGAAGVVPPVVATSRDNSLARTTSYTEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KLK4</accession>
    <name>A0AAE0KLK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B0H63DRAFT_398417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KLK4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="814"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="938"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK3378361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127661" checksum="95BF90192DBF9D52" modified="2024-05-29" version="1">MTRPITSDVPGTAAPEPARLQRSRPSQVRTNLPLLSSSQLVAAPPSATSNSSVSLNSQHASPALSPVTAGTSMTLGSSAQDSPDLLLEPFPSTRELDEMDASSPFFQLPDPIAIPSISRRTSTNSLLSHSHSALKSPAMSEAVKSASLIRRGSNSLKKAMSGLPRPRRHSSTNTRSRDGSVAGLMRRRESASNNPNPLIEHASLHYSESDDDCAIEREDDGFFTFGGDGAPRGASPVSATGSHAESTSSSTLTAGPVVPLALRQGTPLNKVTKKKGLKKITLVLDPDSAKIWWDRNRPSKSIYIDDIKEIRTAEDIRQYRLDTGLGEEYESRFFSIHYTPPGESRAKVLHLVADTEDGFRTWTEALDAISKHRQDFATSLMAFNDKAIRTYWRLEMAKQYGDKPHLPEEEHIDFLGVERVCRSLHIHVSSQELRAKLEWVKGRKSSLDDQPPTQMCSSRLSFDEFLEFVRLMKARKDVRAVYSENAADIEGGMTKSEFLNFLRHVQRENVDEDLAAWENVFFRFARKGKPREAEKAANGSAEEGLTMSEAALASFLTSTSNVVIAKEPKGYKLNRPMCEYYISSSHNTYLLGRQVAGVSSVEGYISALMRGCRCVEVDCWDGPDDMPVVMHGHTWTTRISFLEVIKTINKYAFVKSRFPLWISLEVRCGPATQKNMAKIMIEVFGDKLVRTPLDPSSDVLPSPSDLMERILIKVKQAQSQEEPPKNGEWFGRRRGNSQPSPYQRALESLPSATPMPASPLLSATPLTRSSRFINTITEGEVHDAPSSSPSECESECEKDSAVAKRTMSKIHPDLGDLGVYCVGIPFAGFDTQEAKRFNHIFSFKERTFAEKCQTSESKQTLYRHNMRHLMRVYPNGNRFTSSNFDPLIYWKRGVQMAALNWQTFDLGMQLNQAMFDSGTDQSGYVLKPIEGREIQMVPPGQELPRGKRPRKQVSFHIDVISAQQLMRPWNLGEKRTMDPYVEVEVLLADDKRNKQDVPTDPAPQLKYRTSIVRENGFNPVFNGECKFDVTTKYEDLIFVRWSVKLAEKSKLGEKSFSEKTAPFATFTAKLSSLKQGYRTIPLLDQNGDRYLFSTLFCRIIKGPVTMKMVDYQEDTPKNGSILKNFSFGRNGSPKSSVELNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0KM19</accession>
    <name>A0AAE0KM19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit sigma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma1-adaptin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B0H63DRAFT_251713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0KM19"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="105"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK3378586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="242" mass="27811" checksum="937F77D7F283F805" modified="2024-05-29" version="1">MQSGDRSIGTPSPHCARQWWAVAGRRVWGLGLSKHPSRLRLLVENGRKAWQIRGQPSFLSVTSHFWHSRSSARTRPDNVCLALAKEGLHHGHQLSYPPLSPGESAKWFTTLSPKDKAKIVKDVSQLVLARRTRMCNFLEYKDTKIVYRRYASLFFIAGTSSEDNELITLEIIHRYVEQMDKYYGNVCELDIIFSFTKAYYILDELLLAGELQESSKKNVLRCISQQDSLEDMEVEDEVTKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N194</accession>
    <name>A0AAE0N194_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_92157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000012">
        <property type="protein sequence ID" value="KAK3366525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N194"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3366525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="565" mass="63671" checksum="67211DA3063EE04E" modified="2024-05-29" version="1" fragment="single">AVQIEPYITNAPGLCDFEAASPYHAATPLFPFSPFSRLEQQALDLVGESMSSIVEAIKKRTKGEERTPSRRFGDLGGGEGHGSQNGGHMRRRRPSTTNSTTAEHSRASGNSYLSRVPKRRSSGISKPHLSRQPKHVKFVVDPNDDDDDDDDDGAYFDRGRQPTPDLDGQDVQPVPSPKALNDIVRKLAEDTAWLKAQLESYSEQDLAPNDYTQVLNDQKQEISTLWEGLGNIQKRLEGSSEAHAGCDRELKRLEQRLDERYEQLRNPQETDVTELQQLVQQIASRVSRLESKGLLSETELSEVKTRQDGCMAKIEASSEKHTAQLERMLGEFDKKLQAITAASEAKHNEIAAWADNKFRQQQADILHIEEKLQALAEAFETRDEEMQALAAATKTATVKSMAKQKDLLAQFDERMQALVAASDAESARLQESTSREIECRATAMEDNFGRLYVDLKKEAEIKQQEEVDKKLNAMYNHIIAWVNSRYTEAGSQSRQQGLQTLEKHCTASFKQQRGDIQDLRNRNEAIVVNAAQLAGGIRNVEYSVQRVKYDLQRVERLLRNIYKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N1Y1</accession>
    <name>A0AAE0N1Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_529443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N1Y1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="628" mass="70238" checksum="0C4023DFFABA2CD4" modified="2024-05-29" version="1">MNVYQYSQLQSDSNIRLIRFDSSLTPNGSDLLSIELIEARLSDVSGGGFEALSYTWGNPTENERTSIKVKPGDQILTITPNLHSFLRRLREDDCTNGCSKTYWADQICINQKDVPERNSQVAMMASIYRASRRTLVWLGEAGAGDGDSAALELLRGIDLLGCTRADPLRQVLPKVVETIEARLGDTSSPQSGIGAMAEDETEFKPLLDVLNPWVIQEVALAAECTVRVSDNVFRWESMDLAILAFASMAKKRKGTLAGAPILKTMAAAAIRHIQYCRKTWTSKKAQMRQGDFLHLLGRLSPTMDCTDPRDRVYAYLSLQENEPARALSNADYALTVEEVFMRCSAELAAASRCLEIFAYTRYPPIGPGSENSKVPSWAIDWRLPSTMSGLTRSVDSSFRASGSFEYRPIMPLERHELSPQVLPVRGKVIDVIGATATMNELPRTGDPFILMRYLRWSWILEMISTLWTDQPWNLAAAQTTSGAVLHQKVVKVLLCFDSALDNADGLWDEQLEQALRILETHEANVEQRGPGGETAETELLRRFASMTNRTSVRALYATQQRGLLGLSPPLTRTGDLVCVIHGSRTPIILRRSTMLGRYHVLGQAYLEEWMHGEHIWWSEEEANVFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N267</accession>
    <name>A0AAE0N267_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_536193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N267"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042119669" description="NmrA-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3367992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24337" checksum="AC4F40E09F293ABD" modified="2024-05-29" version="1">MFILIAVVCSYTSHAEAILHAQLGLLRAAEAAGISFGEFEHYNAYLSFRRNVQLTSGIKPVYVFTGIFGQYAALALGNGIAHTGNEPDGGKTLAFWGDGDAKWDLTYLRDAARFSIQLITTKESVLAGEGGFFSIHSGEASARELAEVDGSTKGEKVQLRTLGGLSELQERFERARATVDPRQYFMFLTDYIQGANIKGVWKLENPVKVGAPDAVRLCLRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N397</accession>
    <name>A0AAE0N397_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_535929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000011">
        <property type="protein sequence ID" value="KAK3367829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N397"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3367829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="611" mass="65166" checksum="3EC6CE841B4D7AC0" modified="2024-05-29" version="1">MASEFDFIIVGGGCAGLVLATRLTEDPSLSVLVIEAGEDLTADPRVNVPAMWTQLQGTSADWSFKTVPQKELGGRELSLPQGRLLGGSGALNGMNFVVTSKANLDAWSELGNPGWDWESFSKAFNKTYSLTTPSKHGEKGGPIQVTIPDEDSKWPEAWRDTWAGLGFPVDNNPMSGNITGAVTYPDSIDPTTKTRSFSGNAYLPSASSRPNFTLWTATLVNKIVFDTSDGIVATGVQYTKDGATKTVSARKEVILSAGTINSPKILELSGIGDAALLRSLGIDVVVDNPHVGENLQNHPFCAISFETVDDSEEGYDTIDSLSRGDTAALGAAMEAYTTKKTGPFSKTNCNQMAHIPVPGITTPQVRHELTQLLESTKHSQVNIGNKTAPAFAKAHESFVHSLLNSATEASGYYLSLPGWAYYAPDGNLGPIPAGGSERYFTIAVILSHPLSRGSVHITTSSPSDPHLAIDPNYLSHPLDIEILARHAQFLESTLATSGLLGERLKLDGKRSPGAPPGPWAFEGDLDTVQKFLRETATGAMHYTGTCSMMPRGMGGVVDPELKVYSVKRGLRVCDASIMPLTTRGNPMATVYGIAERGAEIIKASLQTQVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N5Z4</accession>
    <name>A0AAE0N5Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_287842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N5Z4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042295307" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3372072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="215" mass="23298" checksum="165F00B254C38809" modified="2024-05-29" version="1">MFWNLWLGLAALLSLAAAADTAIYQDADTGLTFSTAFALYKSDGRGITFRVAIPSSATNYAKYDAVIQVVVPNDVGWAGLAWGGSMTRNPLLAAWRGSNNQVVTTSRWATSHSLPTVYNDSKYTVYKTGTKSNSTHWQFTALCTGCTSWTDSGSARYLNPKGGNRLAFAYSPNKPSNPSSNTSSFPVHDVHGYWSHDFNAGSNTNFETAVARLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N7F3</accession>
    <name>A0AAE0N7F3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_453591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000008">
        <property type="protein sequence ID" value="KAK3372239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N7F3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042222120" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3372239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="109" mass="10948" checksum="11A8D626A8B69DE1" modified="2024-05-29" version="1">MHFSTIITALLVPLLAVAEDPLQTTTCTSYLTLVKTITLSKAGSTTVTYTNNSTASFSATQVPTPLITPPSSITAQAISKPTTTSGASVLGAAHVAVAAIAGVAVAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8S7</accession>
    <name>A0AAE0N8S7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_481473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8S7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3374981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="281" mass="29588" checksum="FAAE184BC2D37BA9" modified="2024-05-29" version="1">MTVPAAAGYKPSPLGYGSPRSSPFRRPESPASPSPLRHTTPSASPSKSGHVNGGSRFVNGATTTPTSDGWTPRGPPATDDTQTPQQRGTPRAAAGTKPMENGNSLSQLQPSQVRTLREGFQILDRDSDGVVNREDVADMLNQLGLPSNPLDLSPFFPPSAPQAMTLAVFLNSLSTSLAALSPSSELLSAFSAFDDDDSGQIDLAELRDALLHTAPEPGERALTALEVDKVMNGFTGRRAFSRTKTVGIGKRGEVFKYYDFVNSVVGGNGAADQASEDAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N8U6</accession>
    <name>A0AAE0N8U6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_266587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N8U6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042023046" description="Secreted protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13320" checksum="6FD2103C0666808D" modified="2024-05-29" version="1">MASSPARSSPMLACSVRAACVLRACCVLPVVCWPVESDSSLSVLSKHTHLHPLVRCRPVLSCPVLSSHRLHRGGRGVACSLVCLALCSSKFPEVPITASSFSRRGSIIVDFTPGFFSFFKPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N901</accession>
    <name>A0AAE0N901_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_496115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N901"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3374685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="437" mass="49609" checksum="A7143A4F2CDA2C34" modified="2024-05-29" version="1">MRQLFNFAPTYMPLNHGSFGTYPTAVLEYRQQLLRDWEARECIYAKWTYPKLLKESRALIAPLLGVDTDEIVLVPNATTGINTVLRNLVFEAGDVVLFPSTTYSANLKTIQSLEETTPVRGHQMSIVYPVEDDQVVELFRTNIEALVKDGKRVRVAIFDTISSRPGVRVPWERLVSLCRQLGVLSMVDAAHAVGHIDMTHTRVVKPDFLVSNCYKWLYVPRGCVVLYVPFANQHFIKTSLPTSNGYLDPKARKAMSSREYFVNLFAEVSTSDTTPFITIPAALQFRNNVCGGEAAIREYCYRLAFDGGNRVAEMLGTEVLENTQRTLRPRCMFANIRLPVTIVPAERGVQHPNDNAIITEDEVERVLAFIYTKLATELDTSLMVFAIAQSIWTRFSAQIYLEMSDFEWGARMLLNLCERIRAGEWKEEEDRVLDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0N9A6</accession>
    <name>A0AAE0N9A6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemolysin-III family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_496298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3374985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0N9A6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3374985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="337" mass="37866" checksum="3F46C45834AAD2ED" modified="2024-05-29" version="1">MDLGLMESVPPAQPPEARKGRGMEPTTGSNTTLKAGKARRRPALLSFNKMPEWFQRESKWVLHGYRPISNSARTSFCSWPYLHNESVNIHSHLISAILFLLGEWYIQRYLTSRYAGVTGADFVAFSIFMLTAATCLSLSATYHTLLNHSQHVEHLCLRLDMLGVIIFILGDLVLGIYMTFWCEPLPRKIYWSLFSGALTIFMTMHPKSQGAKYRTFRVLMFVATGLCGVAPLIHGLIGFGVSQMMRKAFPYTMAKAGCLLSGVTFYATRFPECRWPGKFDMWGSHSIFHVLVVCAAVYYLLLSYEYMDAYTPSMGLLVTGTSWRGSAGNFTSSFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NAH1</accession>
    <name>A0AAE0NAH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_278807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000007">
        <property type="protein sequence ID" value="KAK3375419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NAH1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3375419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="267" mass="30094" checksum="70CF2A92A9D546B3" modified="2024-05-29" version="1">MSTITSTALQSSQPPIIPLAFNGNQPETIRLFPLSNYTFGVKETQPEEDPSVLARLKRLEEHYTAHGMRRTCEGILVCHEHNHPHILMLQIANAFFKLPGDYLRPEDDEIEGFKSRLDERLAPVGSLGEGEKAGDWQVGDCLAQWWRPNFETFMYPFVPAHVTRPKECKKLYFIQLPKSKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHLLSRYNFEFVNDDGEVVAVTPGAGPSEDYVPKTKVLAGGDDVDMKTENGNHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NBG1</accession>
    <name>A0AAE0NBG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_229305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3377892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NBG1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3377892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="377" mass="38865" checksum="CA042DA54D06022E" modified="2024-05-29" version="1">MSLASAAPAQTSQAIPRLAEPFDSETNSGDVTPRAAADADEKKGKKRSLFGFGKKKSSAAEEGVKSPTRSETSPKDIVAPTSRRTATGSPVPNEHPHYIPSSPGRGFGSSPRLASPAGSQIFERDVQESAALIPNSPAIPSHIQTENYIPPVLDASSEAITDDHLNPDSVEIITHTSHQPAALAVTGGNMTGSGFLEPTSSSWADELAASFAMTSSETTGGGNADSASNYGNLDTTDIRRLSFISFADVVQAEQHQQQGLGLTGSRDSIHMAGLTSLSSVGLNNRNRSPSPIRSPVSSAGGPGSSSPPTSKSGSVKGLEMSPARKPLGSPTISMQHHGSIGGPTVTGELSIETMSQALRRTGSGDLSGVRSFPTSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NCN1</accession>
    <name>A0AAE0NCN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_250191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NCN1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3378525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="649" mass="69881" checksum="F7A7D5B3EFE71B64" modified="2024-05-29" version="1">MADTIDASAGDEVKPYTIHVRTKHLDFTKQKLELTRFPHEGSEPKSTDWWEPKPQLEPLLDFWLEKYDWREEEALLNSSLPQFRTSITLPSQDTPLRLHFLHARSAHAHAVPLLLIPPFPLTCLSLGHLLKPLTDPEDAARDQPFHLVIPSLPGLGFSDPLPNNTSPVTTTADMLNTLMGRLSYPYYLATNSGPGHVSPAKIDWRLARRLATHYSSSCLGTHLISPVLAAPTLRNAPLEWAKWNIASLFRAAILGYSADDFSALPPRPRLWPWQTAGNVVDIEQGLNHLSLREPNTLAYALCDSPAGMLAFVLKAIQPNINHLTQEQIVTLTNLAWLPGPENAMRFWAHSTVHDEEDAAASPAKTTGEKIAKPRVAITVFVGGEQEGGGEENTAATTPAAPAPAVEVTTSSTPPPAPPAILPSIAESQPEPPHIEPFPSSTAGPITPRRSEYIPPAWGNTHFDIVHTQRNTSSTPSTTGLLLAFTQPSIIITGVRGLAAAVLARDARLKPAPAPASTAPLEQIIVISSAPSTTPQQSPPEITPPAPALLAPAAPPKRPQPNRGSSSWSWSGPRVSGPTSTSGGKLTKPQQDPKGKGKEIIEQAVPEPARLSPPARDPLLDGESPDTLVDNSPQPLEEEQEPPVLKGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NDC6</accession>
    <name>A0AAE0NDC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_480300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000006">
        <property type="protein sequence ID" value="KAK3378569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NDC6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3378569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="213" mass="22725" checksum="C99C7C655F863D7D" modified="2024-05-29" version="1">MMLASRFRAATQLSCFSRGLSTLASSPSIKVFDHPQRANSYILSYLDTTPPNPELAIGTTTSIPPTTTSFQGNHRFLTLLNEVLAKYAQDDPGLKSQAQAFASPAGSNFLFTRKKRGTGTGAGGASAEGGAGGAGIGGWVHLSDDRNPPDFGRIAWPEDILGSVEVDGHGNVIGNFQPSGTYRIVTNEGILGLSSFLREKLIARLREEEKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NG13</accession>
    <name>A0AAE0NG13_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_560644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NG13"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3380790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13775" checksum="0C9A30E23F98DA12" modified="2024-05-29" version="1">MAVALWIWAGDKRAVQASFFFRGSGLPLQKTEKGVSRTHTDAFDTRLPLAMLQKIRDNREVLQFKFCLFIDGPDEYEGEAETIVEALQILSTSPNIKLCVSSRPWLPFVKAFNREQRTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGE5</accession>
    <name>A0AAE0NGE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_474671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGE5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3380966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="313" mass="34146" checksum="1A5D46B1138DFDA6" modified="2024-05-29" version="1">MAPPTAFVTSATGTQGSAVARHLRSLGWSVHATSRNPSSADAQALTAIGVRVTPGSWDDEPVLESSIAGCQFLFLNLFPDLNDASRELTQAKTILRIAKATTTIQHVVYSGAFHVTALLPDYPSNHWSTPLHQSKQTIPSIIQSSGFQYWTHLQPGYFMANLLDPKVHFHFKSASETGIFAAGYLPSTLLPLIDHEDIASFVVSAFQNPEKFHGKNITFAGQLLPFEKTIELLGKAASRNLRVEYLSDAEIAQAALSGENFMPEIQKFTRRMAELVDVEESKAWGVQLGTFQAFLDREADAVKATFANVPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NGN7</accession>
    <name>A0AAE0NGN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_523874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NGN7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="421" mass="46058" checksum="8F7111485493E6AA" modified="2024-05-29" version="1">MGSTGVSFDATKVELLRAAAELTAAINDYVATPAPEGAEGAVLEQRRRRDIVDATDRVQRLVKDPADQWIDVVYPQTLATTKRLFYDWGVFEAIPPEGSISYADLAAKVDAEEVLLARLGNILVGAEVLGQVGKDAVAHTDSSRIFLKGHVGGQLFNLSWDNCLTVYPAMPKYFETYGRKEPQTSNHIPFSFAYGLPEQGFYDVMSADPAKMATFIPAMAAVESRMPVAGVYDFSWVVSLLADAEKAPAADRPVLVDVGGGKGHAIKAIVNEFPGLPLDRCVLQDRPDTIDAVVALDEPELKGVTKQGIDFFKEQPVKGALLYFIRRCLHNHPEAHCEQILKHLVEAAAVDSKILIFEDVLDTPPHYTGAIFDFMMLGMGGKQRTQEGWEKLLAKVGLKIASISRGQGPWRSQCVIECVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHD1</accession>
    <name>A0AAE0NHD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_206467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHD1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="174" mass="18809" checksum="7331B3A4FDAE962F" modified="2024-05-29" version="1">MSLMVSLDASDLVPILLVLLVACQRSRQFLRNTTPDRCGCRLVNPLLCSILCCSAVGGGMCLIHRAARRFQSPTLSAHRAIAIPETRFPPLHQDPGTGSRALFDCGLTAAPGPNRPLGLLASRRLVLAPAFAGFSFFYDEIMKERPQAIQPANLHLPRPVCVCSEFVHGGGHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHF7</accession>
    <name>A0AAE0NHF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_207327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="239"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="736" mass="81310" checksum="CA9FEE9C75DA9230" modified="2024-05-29" version="1">MSTPSAVPRTAPIAIAPKPPRFPPSRQGSLHLDPYPGLRNGIDSPDSDSPNGLSAAGPCESCLRNRMRDCVMSDDDESCIACLVSGAECSLAESPPPRKRKLNGHAEDSHSKRSSPGRSDNRRRRQQQHSLSSTTASSSLIEEMANFGGPTMLKRTLGLQTDRYSQYIGPTTDFEPSLINLSSFDPHDESLLARGTLRRVSENETFLMLPDNNTPGHEHVLDDVDEIESIVAPHGRKLIDLYFRIVHPGFPIIQKTVFFEKYERSYREFSPPLLAAIYILAINWWDHSEDLAPLTRPNVRELERLVRTTLAEAMYRPKLSTIQAGLLLSQRPEGDQWAPTAQLVAIGQELGLHLDCSNWKIPPWERGLRKRLAWSLYMQDKWGALVHGRPSHIFSSNWGAQPLTQNDFPDVEWDENDEEERLEIERGRMLFGQMVQLSLILAEILEAFYTLQATQAVANAGPQGTQLVLSLAKPIQLKLKDWYAALPAAIRMDSTFQGGSPTGLNGTGRLSSIGYLHLAYFATEITLHRRIIRSIEAGAVAEPYIQHICRSAAKARLISAMDFVNRLNHSHLRAFWYFASKTNFALIGTFGSLLWATSPGREEAEWYRRRLGEYRWTLSVSSKPGETKGLTEFAMGMLDITTGLLKQLPEKPLLSRHGSAVDVDAARRQSILALGGMSGSMSMTAMSGIIETGSYSAGGADGSGMQSPRSPGGSDSSDEGMYGNFSATAGMAGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NHT3</accession>
    <name>A0AAE0NHT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IBR finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_476630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NHT3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3381796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="295" mass="31160" checksum="9C7A620AE0BB5293" modified="2024-05-29" version="1">MGPQKRTILITGCSDGSLGAALALAFHKQGSWRVFASARNTSRLKDAEAAGIETVQLDTLSDASIAASVSRVAELTGGSLDALINNAGAAYSLPLMDVDLDKARGLFDLNVFSVLAVTRACLPLLLKSTAPRGAMVINNTSAASQTAGTVPFQGIYNASKAAAASLTEVLRLELAPFGVRVINLVTGSVKSNFFDNAPKATLPPGSMYNVAKAEIEEAMTGKDTDKNGADQAEWASQVVGDLSRSSPPHWVWRGTYVRLVWLASFLPLGVFDGKVKKMYGLDVLERKVKEEAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI12</accession>
    <name>A0AAE0NI12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_511578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI12"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="286" mass="32016" checksum="C3A43E2ACF81AA8B" modified="2024-05-29" version="1">MIFGPCSIAKVSRIQARQPLHLKAILLWQRTQQQPRGNHPHLCLNMDKDWVLIPNLGIIDVRMPNSKRFLELCVNTGEFQCQLAEIDISDVKDDGQLFCNIQERYVAARSFRVKYFFIKPIDIHFVQFSLEDRYRVGILDKPMAIPCEAEMAAEGYGYHPCPLKPPPFPANIFLHHLSRQTGHRRLIWGNRIPQKLHQSILQGGGGGGNGGVPNDLVLGWGVHIIEGLNKVTILFAMLGAALVSGVMSVAWVVVRDDVQGGFAIGAWLTDLRGIIVILVATKWSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NI13</accession>
    <name>A0AAE0NI13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_524597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NI13"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="562" mass="63246" checksum="ADC07F56F028B798" modified="2024-05-29" version="1">MATNGNRPVDENAKALDDATEYSTQLASLIKDNTHKTKGVDVLSNDKRLEAWAKDADNLATQRTKFELYVAAQGATGASKTSLLNAVLGYKALLPSSSAEAATATICKVAYNHSDDPAKLFRADIFFRTRDDMKKELDDFFDDIKQRNELLGSFDAPIVEEFNANIEDVARKVNAVWGYAMEQVEVMSISELLTKDDPTAKLLSTTKSICGKDPEEFAREVKKYLDSTYAKVTGKAGAITRRMALWPLIDHRTAWSSEICEGRLLTPPSGHGTENRLSEFTATCSSAIKLSEEDLKSKILDPTCDKLLQELHKFGNQLTRKVAACDALKVMEKPLLECAKFSDETAERWILRNPRVRTSIRRLHYLTFGAIIQRGGDTFTSRSEGVSTTYTWMQDILAKTYFQGQEDYLQSRQVTLHEIKEEAKDLVAKALRDISAQSSGIHEDLTEHISSKWRKLFRKAFEIRGSGYMKRRHDSLLEFSQKHGKGIYKDAVADMEARLKENFQELHSTLDKAWKHGLQRFRAQMSLIAGGVIQDEHGKRTKNNSVPCRTGPTCRWAYGICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPC8</accession>
    <name>A0AAE0NPC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_472209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPC8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042288383" description="VanZ-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3385035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="219" mass="23490" checksum="142C57A1A6F99D95" modified="2024-05-29" version="1">MKIRLPFAGVFFLLLFLAGYAGLSSLQVDAHVDDKVLHFATFFALTIAFYWIIDTNRRRTLNLTLVVCTLGLGVGSEFLQALLPNGRDFDLFDLVANVIGSLAGLGLCSWYHKRMLERKRLRKYNAVPGEDGGEDDLELGDGVGLGGDGHEEGVITAGASGVRATSLEDEVDNWDENAVDTWEDDDLGDIGVSTVGAGAGSGKDIEVNGDHGGSKKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NPR0</accession>
    <name>A0AAE0NPR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_559988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NPR0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="242" mass="27674" checksum="465D8C8398791314" modified="2024-05-29" version="1">MVTVLSPSQNGKPWSFAIKSTDIILFRVREELSKSASAKPRKDLEPYKSERYGRMLFGFGILAARGIPRVDFTLTLPEDPYNVRVRQPIQRFYGAPKWTEDNNHSLKEVVPQPELQRCDITNRRGDKCGSIVEAVATENLVKGTGPKRQQFEHDEQVATGQGQLNTTTTTATESEFLAISETKTFTKDEFPDWIYYIPTERVESEWDLFFVLPVEHFPVEGFYRRVALGKVFRAAFAVSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NQT0</accession>
    <name>A0AAE0NQT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_473631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NQT0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042211277" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3385814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="98" mass="10555" checksum="A4F2586E6171D084" modified="2024-05-29" version="1">MKTSFVLAIIASTVGVIADSALLSCGHHLVNSGSWTQSQIAKAACGRTDTCNGEEWNTIFEILLMSSGPSSWVEIKSRGVFCHKGCYGDIDKYNAQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NRY2</accession>
    <name>A0AAE0NRY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_540546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NRY2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64865" checksum="41F7304CE986AFDE" modified="2024-05-29" version="1">MEWEIFWERAALETISSVILSGRPSLPSASMSAFQFYTVGSSTKLIGEELAGIPSESNHKKFGAPTSAKVLASQFIKMLEFSATLDTTDPRDRVFALAALFGAFGINIPKPDYLKPTEMVFQELLGMLKTTSVWPPRQPLAPPSQYPSQGLALLVRNENLDQHPAGNRQNQTENSYSPKAIGTASGASTQQSYHAFFDHILQHHKRLLFSDILHRLAARVPHGPLICLDGEDPATTREDEQASGSQLGAVHGRSAAAKERSVAKRKRQGGPRKRGEEDNEDDEEEGDERQHKKRTADPWNRLACPYFQRDLDCPRLSTSCRGPGEHLYRVHHIHPCLRCGQIFESREALSQHLQSVQPCNLVHWRPTFNPSQGFEDPQKEKLGKKTVRTWQQIFGILFPHYSNTGFVQLLDQFHQHYVLECQRILPQRLANDSSTFHELDQGQQQQGRLEAYVLQLVSEIFDQILGSFRRELVRTPPSGVHEFAPRHARGDEHIPRPAAPLPQEEPVVQATLQSMHQLRPEDAMLDPVLAFGEYLSRVAPAGTFDQVPHNPLGDLQDVENGREGNEWTWEHLGLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSA1</accession>
    <name>A0AAE0NSA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_391881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSA1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3386771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="558" mass="61796" checksum="A8CAF63F970C02FE" modified="2024-05-29" version="1">MEALLANQLAREKKKSRNKNWLIAGITVVAIGAHYFNRPEAASLQVLQQATESTPLSKVSVPKQQAAPTVAPTVSLQDCLNAVCAGRDDCVHYDGHGSFKYFFEWLRPLNLAYLFTPAAVVRPRTAAEVSAVVKCAAQAGVKVQAKSGGHSYGNYGLGGQDGSVSVDLVNFQDVWVNTTGNSWQAHIGAGGKLGDIDEKLVPFKRAFAHGVCPGVGIGGHATIGGLGPMSRMWGSCLDHVEEVEVVVADGRILRANNRENADLFWALKGAGASFGIITKFVMKTHPEPQEVVDYVYNFQYSHMEQMVDFFVAWQKLVADPNLDRRLGTEFMLHPLGARVSATWYGTRDEFRKTGIPNRLPSGNDSFAINENSWIGHLYKAAQKEALKLSDIPNHFYSRSLGFTRNDLLSKASVMELFKWVDEAPKGTLAWFIIFDASGGIISDLPNNATAYAHRDKIHFYQSYGLNILHMSSKTKAFLDNFHQNLLNFLPARDPHGTYPGYVDPYLKNAQEEYWMGNLPTLEAVKSKWDPQDTFHNPQSVRPKTSAKLEFANENLNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSB7</accession>
    <name>A0AAE0NSB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1445 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_468367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSB7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3386776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32475" checksum="81F71C0BACE48E18" modified="2024-05-29" version="1">MALTNATNNGRAVRLAARSNTLSSPTAGLAPSYLQANLIVLPRQYATDFRLLCARNPVPCPLLAESDRPGSFNELKSYIRHPSSSSPVTVASDIDLRTDAPKYRIYKDGTLAGEAADIVDAWQPENHVGFLIGCSYSFDDALSAAGLTPRYVAQGFNVPMYRTTVPLCPAGVFVGGTVVVSMRPYRSSDITKVRDITRAFVTTHGEPIAWGWEAVSRLGIADVGKPEWGDVPLTADGKRVFGCQDTKEEDDYVPVFWGCGVTPQEAVMRANLTGTVMGHAPGHMIVLDVQDRDVFPEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSD8</accession>
    <name>A0AAE0NSD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_520893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSD8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3386817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="216" mass="23603" checksum="2F59A9C037F040F1" modified="2024-05-29" version="1">MESFHCDKIWFGPLPPFKFEDPALRVKDVSLPNLLKSSAKLTNIQPGLGVIVEGVQLNQLDDAAKDELAYLISHRKVMAFAKQDLIDDGPTAQQEFMDYSGKRNYQPVSGSPPGYVMLGLLQGPEIGGDTVFAATDAAYKRLSPALQSLLDKLQAVHTSIKMIGHAKAAGGLVRKDPVETVHLLVRVHPVTGQKCIFINGGFIARIVGLKNQRERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF7</accession>
    <name>A0AAE0NSF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_468510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="668" mass="72367" checksum="5730241387830EFF" modified="2024-05-29" version="1">MAALLLGNKIKTTDSDIELLVPRAHVSSLSLETGFPYPEVDDDYEKLLPTNSLSPGPKTLRQSILGWLPEILACALSLLCVTAIVATLLVYDGQLTPNWPLGITLNSLLALLTSLAKIALLAPVVQGIGQLRWQWFSQRYQRLTDFDLFEEASRSTWGSFKLLVSLKGGIFTALGAFLVVTSFLTSPITQQAIQYPTKLVPTDAQASVSRVTLYNYPIPFSQNSGLDMSIFASSFAGFKKNMLSGAYSTDGTPLEDSPPVCSSGDCTFPDFVSLGFCTKVADVSDRLTVKQADDRDWNLFGLEDNSTWTASLPVSSAVLTIPNLRSLDFFADLTGGSLSFLDAPESNTSSLNVYLIYSNPPATPGGHVTFGAFEILFYWCSKAFSLNVTATTAHWTELGRSTSIKESNLSTLNIFKNARFIECMLGIGVNCDNTSTWGRMALAPPRGFESHRNIVIEERTGVAIAAALELSFMPSPLPPPRPETNESFVNSHDGGIVLIGKGMYRMNGDMSLALGTALWGLAPPGHPLLPSAQLDAAGFVFGNMAKGLENFLRQSAHMYEGNSASVNGTALSPTPYVEIEWPWLVFLMAELLLSVVFLVGTLMLTHSAANMQTIKGSSLATLCSLDESSRQALGGMHSLAHLQERARRAEVKLERNDDGGLWLVSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSF9</accession>
    <name>A0AAE0NSF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_493390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSF9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3386699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="497" mass="54178" checksum="3772581D5BA9A330" modified="2024-05-29" version="1">MWDNSSRSAFRESGLQSVYGTGRDAWLIILSRSCRMFAYGASSLILALFFAELKISDAQIGLFMTLTLVGDVMLSLLLTLIADRVGRRRTLCVGSLLMIGSGITFATCENYWLLLLAAVVGVISATGGDFGPFRAIEESTMAELTTPATRADVLVWYVTAASLGSSIGSEMSGRIIESLRARDGWTLLDAYHGCFWLYVVFGLLNMASCLLLSDRCELKKKPQQQVVETQPLLSEASSSTGQEVVEAESKTATGKSSWVAQISRETRGVMTVLWFLLMVDSLADGMVSMALTTYYMDQKFHLPKSTLGDIFSASYFLSTCSNIFAGPLARHIGLVNTMVFTHVPSSAAVLLFPLPQSVSVSVALLLLRVGLNNMDQAPRAALIAAVVRPEERTAVMGITSMLRTLTMTAGPTITGFLAGDDRFWVAFVAAGALRLFYDLGLFAMFINIKLHKHEPTVDGEEERLPAEESQRAHVHLPYGLLQHDRPTQNPILGGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NSK9</accession>
    <name>A0AAE0NSK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_391371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3386759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NSK9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3386759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39153" checksum="33E2D4BB1CF54546" modified="2024-05-29" version="1">MLPPVDDAILQNNPKFAALYATLTNVILSPDGSTKTDPAAKERDAVRGKLDKHRLKSAKQHLLIHAISTANPTQPEARLTLPASAVNRRAKPQPPSSRQDRGASSSTSELPAPLLDLLLLLPPLLTATPSTLSPESATLLLTSPPLSEFPTHLPQLASLVSSNLHTSAVHLARIANPNTNPSFIHRSLPSLPAYATSLTASLAERKAALTKARLSAATELTSLLQSQSVVLAHLLRALEAKHGPIARSLEFRAREVALAAQKQETEAETALWAARRDTYTPDVVRALTNYAGHLRDAKSRMGEAIRFHQAELEAYGVAVDDQQHEKGAKERTMREMARVYRDMGRQVEEVRGDLERLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NT20</accession>
    <name>A0AAE0NT20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_469507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NT20"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3387206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="283" mass="30657" checksum="CCF2E085B840A31A" modified="2024-05-29" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLADPSSLSKISLITPNIGMVYSGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDEGILPEKEEGEKGKETEESSEEKKKPSGKTGGIHKGGPMLYQVDPSGSYFPWKATAIGKSATTAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGETIEIGIVGPPAHHLLGVEGVEGAQGPRFRKLTPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NUU6</accession>
    <name>A0AAE0NUU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">GPI inositol-deacylase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_542573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3388025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="6">
        <location>
            <begin position="235"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="453"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="7">
        <location>
            <begin position="736"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3388025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1693" mass="189604" checksum="114A8728D8184043" modified="2024-05-29" version="1">MRQARLALGPHAKSRSSCLPPEAMGGSHGGMLEDEAANHGENVEITTHFTRGRAYASPTFGKILKSFRVNRDNNLCHTKELTSPRALRQNDAQQPLPPSPPMSPRTPSGIFNHKFIRRMTMRSTTTTASSESRRQSFTEHRYWEGVGPHGLHCLHNPPEPFVDLVLVHGLNGGSYKTWRKKDERGFFWPGEWLPNDPEFQNVRVHTFGYPADWLAFRANNFNVTDFGSSLYGHLMSSPLLNRGDNLKTSIILVGHSMGGLVIKRACLAASRAKNPSNPNDLATRIKCLVFLGTPHHGSNSAERLDRILRSGANPLRPRDFVGDLRPESLSNQTINDEFRYIAEDYDLLSFWEARPSPGGLGYVVDKDSACIGGPKHEIILPLDGNHRDICKFESEDDPNYRILHDHLVKMVDNLIDISWEPEPDSLENLDVYLDCEESHDETLETTLEQTVPGTCQWIQSRKDFASWMDNKSNSQSVWLYWLHAPPGTGKSFMSASIIKTLQDQNRDVAYFFFVNGDKYHRNVAGLLRSIAFQMSQSQPLVSNAIRELQGAGVHWNEADEKLIWRKLFANCILKLPLTKMQYWVVDALDESVDSAKLWPLLKSMRPKFTVRIFLTSRTLADIRKNFQQTETTPSSKNSSGIRCTEDTIRPEDSHDDIRRLLQDKESEIPMAEDGDQENMVDQLVRKSEGSFLWTRTVLKELETAYCREDIDVILKEVPSDMVHHYHAIFRQIFETAGRKKLLVKAMLAWTVCGVRPLLKAEMQQAMLLDVGMDITNVQRTVEGLCGQVLTVNKQGAVQVAHATVKEFLLDKKNESEYSIRREQGNLRLACACLRYLTSPDMRLEGRLHILMPERESIVERVSKFADYAATAFSVHLVNSPADDEELFSLLVKFLQSPNVLCWMEFVAEKHKSLVHVKEAGTNLKRFMEKRSRSLPPFGPGVELVNSWSTDLLRLVSKFGRNILMAPSKLPLLAPPICPQNSAIHKQFAKRNPGFRVVGIAEDFWADAISYVEHFGPRPTAISLGQRYLAIGKESGEVRLYSNDTFEEFGDLMHGGRIVAMKFGNSGNMLVTSGPKEIKLWDLEPDSPCLVWTKTVNQACTAFLFADDDESLIAVSSSKLLFTFRTDDESSDESDEEECSSDGVKEIQLDSPSPDSSAATEGSVLTTSSISPDGKLVALVFENQPISIWSVSEGAHLGFCRRRGEMDREGQQDSIDRILFNPNPDLECIVVTYRHGGLALVDYNNLKEVQFVETEACALASCPDGHTLATGDTAGKIRLWDFEKLALLYVINYHSSPVRELRFSLDGLRLVDLRETHSVIWEPAALIRTCDEDDSTSASGVSVVGLRPPYEVADYEDPVEISCLCMHPSRPIAIVGKDNGSVDAYDLSTGCKLSTLFSIDEGRITKIAMHENGLLVCACSANKVSVSLVEDVSDDENDVRKAVGLKKTLFTVPDFGEPVMQIVIGSSGNELLIAGKHTTKLWCRTPDDASKFDLIDKSIDELIPRTTVHEVQPLQKGHQPHWKRLHRHNTLPLDGEADAHHTHVRLRTALVDPGTGYWILEYEGAKSMRQLLILEKVSTDSESNGMLSPPLSSPGSGGAEPSSFRILVHLKPYQIKMFLGLHNKQVIYLGPKLWVRTVDLHHLTPGAKPVKRKHFFVPHEYLGGNHHVDAVVGRGGEIIFPRRGELAIVQGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NX65</accession>
    <name>A0AAE0NX65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_98397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NX65"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3389398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="249" mass="26883" checksum="8F1DACE461B73522" modified="2024-05-29" version="1">MDESSSDTKFEAHSQTPKAIAVSLSAKANVNKDVLKSKGSVGKRSRTGCLTCRKRRIKCDEGKPTCKNCLKSKRECEGYHQRLIFKEPQAMNGRSQAGVFSSHSKIPPQAYDPGVEGDLEPIAPRHPIANTSDCAFPLMVPASNPVGRYGFSTAIKPSVAVCDLVNADIEQSEATASPNLITFGSRATRSPRPPRESNDEPAVGRPDAVKQEESLENLLPPPNFVTATGVPLQQNTKEGSNKAHQENMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NXC2</accession>
    <name>A0AAE0NXC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_556574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NXC2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3389411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="487" mass="54307" checksum="DA1BEB40DE2182D1" modified="2024-05-29" version="1">MSFRPSTASRPQDLDGQLSEMERAEVDRQLVRRLDLKLMPWLCLMYCVAFLDRTDVGNAKIANLTADLGTTDRQFGQVLATFFASYSIFEPLANVLMRKFGPRRFLPTIAVIWGVLMAGMGFVHDWRLLFVPRVLLGAAEAGMFPGICFYISCWYRRDEFGVRVAIFFSSAAVSGSVGGLLAAAMQSMDGIAGLAGWRWIFIVEGILTMIVGMASFWMVHNFPEDATFLGEVDRARVIARLAEDRQLPWCRLETFSWKTIWTSLTDWKTWMGMIIFSGALMPVYSISLLMPSVISTLSFTTPESIIRNQLLCVPPYVMAGAVTVIAALASDQHHTRGYFTIALAPIAVVGFSMLLITRAAEVAYIGVFLATIGCYASLPIVVAWIANNAENNYKRALVLGIVIGVGNLNGIVTSKLSLEEAYFFRTYSIIVAYLGIGLFGGSILFRYFLYRENMAKEAGRRDYRLDNRTAYELQVLGDRNPGFRHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NYV3</accession>
    <name>A0AAE0NYV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B0H63DRAFT_106897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NYV3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="190"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK3390079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="536" mass="59624" checksum="18E630147C2DBAA7" modified="2024-05-29" version="1">MASSYALPTSAIPQFHHHASDHIAHSHSHSHSPSSGSLNPSLNPSRHRRDSRATGHGHQRRQTHEHNQSHHQANSTLPMQSHVHLPPPLAPSAHWRTESTPGGKPLVTPTDASFDLAHKYEPPAASDSHDHHDHDHHDHSHDHAHDHAHNDKHDHAHAAERSKFTALVLPYTSRWPLVHTIMTEMDSRRIFYFMMLNLSFMLVQAFYGYVTDSLGLLSDSIHMFFDCVALAVGLFAAVASKWPPSERFPYGFGKIETLSGFGNGVFLILISVEIMFEAFERIIDGRETKRLGELFVVSSLGLAVNLVGMAAFGHHHHGHDHVHSHGHSHGEKSVCNGHGHGDSHDHNHHAEKKHGHDHSHDNENMHGIYLHVLADTLGSAAVIVSTGLTYFWRWAGWDPLASFLIAVLILLSSLPLVKSSARRLLLTIPPEIEYNLRETLSGITGLRGVAGYAVPKFWIDDRNSGEANKLLGVMHVMAVRGADMDDVRDRVHKYLLEHDIDITLQVEREGDTSCWCGVGRSPLSISHKPTKSIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0NZX5</accession>
    <name>A0AAE0NZX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_557616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0NZX5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="78" mass="8695" checksum="0541D70DFF113EF2" modified="2024-05-29" version="1">MPISKKAKIQREHKKAEAAGTRAPVKANGLPVKAAKPTSICAFCRKEVVNTNKVQLEDHAATHDAKNWPKEKCWPNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P014</accession>
    <name>A0AAE0P014_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_124339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P014"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3390853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="151" mass="16397" checksum="0188F862E50884E2" modified="2024-05-29" version="1">MTSRKLISSGSPFEAQIGYSRAVVSGEFVFVSGCTGYDYKTGVIPEDVVAQTEQCMKNIALALSEAGASMADIVRVRYILPDRADFASTWPVLQKWLGDVRPAATMIQAGLMEEVMKIEVEVTAKKGSSGEASSPLLWSAARGIYRQHETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P075</accession>
    <name>A0AAE0P075_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_466771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P075"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3390912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="348" mass="38760" checksum="E1B1A438C6B2352B" modified="2024-05-29" version="1">MSRCVVDDEADYSLHGSLNPASPTYTKGSWVSLYRQQSKTYESVSYVYSALPAAIQSRVRPFGPLRQKVRSPWSSVSSSASTSEEPDLAMISGPMPVPDQSRTMSMADKKGLHPDRAISIAEREAAIFSEPMQLSAALSATPGTSANDNASGVGWKFGGLGLSLILSAGRNSRATQYREPQDCRYERQAYISGLKFILQGLPEDLDGGELRALRDSMPAQLADTLPALDEDNARLGWRRRRSNNGNFIHNSLLFILVYLNAWVRWFMPYIFYWFSELMRYEREHKVLESVIGTGMAAARAGYVAIRKMGDGVPGQFLSELFQYASAGVSGAFKEFAESELRNEKQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0I6</accession>
    <name>A0AAE0P0I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_467381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0I6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="455" mass="50823" checksum="4B23B62C42C00968" modified="2024-05-29" version="1">MALDPGTILSVVDLVQRALAIYNRIDGLPQQMVQLGKRMQSLNVFLLSFEAFVNQKQSAAFATLYPGQKDEMGRLLESIKGHAAKAHDLFDRYEKGIVSRTHDVTFRFGWAAQMWFSLVENSPEKVQAVMDDIEVDRRWLCDWLTFLNAAILVNGVNQESRPKKPAPIAGPAKDSKKGDKAKGGSSASPGKKNNSPTSLKQPNPAARRPSLSPSPAPPKRDYKILFVDPNNEGRSVAAEAFTKLLGELTRRANGDWRIAFAHSAGFFVKARGDCTDVIEGLDYSYKSFKLPFKDGGASPTKAALAALFDNTAYDYPFKKPIRDEITARKSRGLRRDMFAMYDYILVFTSREHDNIIKLKQALLQKYPDLEIPRGKGRVLHLGTFVAREANGRPREIIVPKKSPGWMETREMWNLQMGVIKTAVKKFLEQELKWKRPDNVAVASGSVLAVAKSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0S5</accession>
    <name>A0AAE0P0S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_520354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0S5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3391160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="190" mass="21487" checksum="C9663A6EFF1F9B6C" modified="2024-05-29" version="1">MKQAHKHLPRLHLDHSTPRHEYLWIDSLCIIQSDAQDWAVDGASEGDGECCIDKRSYSAEGVLRMECPGPEGGKNSKNTAVYARRSQRGMYRTLAKLRGGEPVQGGKSAFGQPLDTRAWTFQEELATRILFYTEDELQWRCSQANACECRGTRKPPKGYRNSLRVKLAEAKCLTLMEQISKPLTKWTLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P0Z5</accession>
    <name>A0AAE0P0Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase u61 ld-carboxypeptidase a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_467606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P0Z5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237:SF4">
        <property type="entry name" value="LD-CARBOXYPEPTIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="MURAMOYLTETRAPEPTIDE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LD-carboxypeptidase N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="LD-carboxypeptidase C-terminal" evidence="4">
        <location>
            <begin position="228"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3391265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="378" mass="41242" checksum="581BBC396589D764" modified="2024-05-29" version="1">METPALKPKALKKGDKIAIVSPSARLNVEFHAAISRAKSVLETHGTLKSTVEIFWTDSDPKTTTINHSVRHRVAELVAAFTDPDVRAIICTIGGSTANELTRLLLTNETLAASIVQDPKIFVRMSDITILHWVLAKHGLRTFYGPAALDDLGEASDPSDEEQPLHFSLENLIRAICDRPDKAPIDQVARSRNFATHLPDFWNGNPSSTLPRILSLTPPWTWLRSGKARGNIFGGLLHAVVRLHGVPELVPDWAGKILFVETATMDGNDEKGTPLSRVQQHLVDLTAYGVFDKIAGLIVGRPIGYNTPAELEAYGEVVTNVVVHGGLHSNPVEFPILFNVDIGHAAPMVTIPMFAEVALDSAENRFEIIEPGVKFSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3U5</accession>
    <name>A0AAE0P3U5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B0H63DRAFT_456450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3U5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK3392720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="607" mass="67295" checksum="DE3A79828CD846D2" modified="2024-05-29" version="1">MSTESTRPLLLPQNRKLRHLRGIFLRNLAFSRPRGRTIDDAALNKSPAKLEALRNAPQLHHALSSSDLRPTAGRRRSTNLGNASPVTRQKRIEDAFENRLADAFFSLHVEGEEDPIYISEIAERAANFDFRFFELFELGLPITQSPNVTVRVWTKRQGSWSLLLEDEVDLRALNWLGTLQNVHFPPNSLVFHMIDGIYSLELSNKYPPPKKTAALPTSSYNALMRLATLDNSIQDALATRDSLAQQINEYLEKEPKNEVPQAEDQLALANKYLSQQRRAVEAAKQRNEGLKASIAARRAAIAEGRALQEKAAKDVENATEKLKQSHKSVAETKEHIRGQRRRICEDLSRIYNIVPVPMGPPLSFQICGTPLPNTVYDSTLKSAGEDALSAALGYVAQLTDALQYYLSVPLPYPINPFGSRSSIRDDISQLPDPQREFPLHVPRGGSSAQFRFDYGWFLLNKDIESLCNSQGLKVVDIRHTLPNLKYLLYVCSAGSDELPERKRGGVRGLWAGRVKNWGANATGGTGGDDASSMGGSRRGSDASDTLGQHRDDLRRAIKESASGSNSNNNGNNTGPSKAVPSPRSLPFADTETKLTLRTRGLRENAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P3V6</accession>
    <name>A0AAE0P3V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_443146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P3V6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="420" mass="47480" checksum="05A6CF939E187A62" modified="2024-05-29" version="1">MFHDGRRVSIIGVSTNGKTVFQEGFGCRSKSQRTKFGSEAPDGETIYSIGSITQVLTASLICILVDEGKLEWHTPVSDIIGLKSRSAFHTSHMTAIDLLSHRTSLAGSDYWWTECKSELFIQRSETLFFFNALQPTGSLRSSFKYNNWNFAILGEIIEELTGESYDTVLADRIFKPLGMERTSAAYMCGDNMFDDNFADAYAVLDDRLPFLLAQPAVAGENEAHLVLQNYGSLPGYMDLFSIVPNMDTSIVVLVNSSGLGDPADWIYQLILETIIETKTPNDYVALAKEAALYHAGSIKRIVSNKEKARRNIPLRRPLSDFTGHYRDSNQDFAIVVRQPRQYRSKAQPQILFRGRESQVWDLVHYEADIFRLDATFNDLAKRSMSTLVDSACFTFRFDADTDGRIWRLHWEHEPAVSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P5L0</accession>
    <name>A0AAE0P5L0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B0H63DRAFT_459405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P5L0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK3393858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="677" mass="73743" checksum="2DABA7477FD00CE2" modified="2024-05-29" version="1">MLRTSLRSVRALGSKPAAAAAGRQWQVAAARRAGVSQRSYANDPKPVVKPIVLPSSETLTSPSTPPPPPQETVASSTIEPKDAPLEPPAPGSPVAPIAEAEAPPPPPPPPPKKAGFFRRLRNYFLALTILGALGFGGGVWYSRINDNFHDFFTEYIPYGEQAVLYLEDMDFRKRFPNVARRQREPTEQVRIPAQSGASWRVADGGETGGRQSSAVQKTAASAVAAVKEAVKPKEPEPVVEAKKETAVLPKVESKADLAKDVKKPVPVPAAEEPPVPVAAATVPVVAAKKPFKAPEVNEPSRWPPASPIDPLAVPDATEPVVQDLARMLNDIITVINHDGANERYGSTIGKAKDELNKVGRKIKDIKAAVEKDAAKQVRARVDGFDKAANELVSRIEATLQAQEAQWRVEFEAEMERVRKSYDEKVQLIQQRERQISEEKLNNTLLEQAIALQRQFAGDVKKQVEQERDGRLGKLNDLAAAVADLEKLTTGWNDVVDANLRTQQLHVAVDAVRASLEDAAHPRPFIKELVALKEIASDDPVVDAAIASIHPSAYQRGISTPGELVDRFRRVATEVRKASLLPEDAGVASHASSYVLSKLLFKKQGLASGDDVESILTRTQTYLEEGDLDNAAREMNGLSGWAKTLSRDWLGEVRKVLEVQQALEVIQAEARLQSLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P617</accession>
    <name>A0AAE0P617_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_505767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P617"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="581" mass="62184" checksum="DABA762D50850CCD" modified="2024-05-29" version="1">MKGSQKSDDQKVDLPYSQQEEHTVPPMNEVEHHHHGDHEKRLVVIPIEEEAVQEAKHVSLGWRSWLVVFITCFAIMAQVFVVVAAGSVIAFIIRDVGDPSLAGWIIQISSTASTLAAIPPLIAFVGAVVSAKATSMNMLIGGGILIGTTLSTISIVQAIPSEILPLKYRALSNGFAFVGGCIGGIIGALGAGAVTNIDAGGWRNIFWMQAAFHGATSLGLLLFYWPPKIDRPKLSAREILWAIDPVGSFLFITSCTLMLLALDWTGGAYEWSDPHVVAPLTIGLVLLVAFVLYEWKGRDDGLVAHVFFHRDANFALSVFAFAVEGWIFYSAVNSITPQIVLNLGFENNAWCISVRNLSFSLTSLLFSLVVTWWSTQFKDLKSPLLVTWVLFLVLTVLYAAFQPHWNHEQIGFNVIGGISQSGPLTLLVACVQFTAPHAFLSTATGLAFSARAIGGAFGSAVLDAIINGRLAARYAPAVASAATGAGLPPDSVPALLAALAVGNVGDLTIPGASPAAWDAALVESRLQYTEAYRLAWSSIIPFVVLAIVAVARLKGVEELMTEKVEATVEHVGDKESEKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P675</accession>
    <name>A0AAE0P675_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_32492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P675"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="94227" checksum="32F5FC8B5D464C99" modified="2024-05-29" version="1">MDSPDPTAPSTHEKTNRIVSEYLKGKDQQWKALYERKGRLTLLELPVDILRLIVKEITHTNDLTALALTNSALYNLAVPMIYSRFDIVWPDGNVSSTESKSVDALTYGLSTLCLGSRFARTTRKIFHPNAHPLAKFSGNEYAKYTKKFSLGNGPDEWVTEYMVTKESGKMLGTLVALAAAKMKNLETFVWDMPTGVLSDIFMALSSLGDQDDNECKLSRVWVRWHDNSEHLGTSSPSNPSAMGGVPPAVVPLGSQLTPVGILLPANASHPTPKAPVSYSQHHCEYPTFSVLPPLKSLTVLDIDELAYLDEMAVLIERSKDCLQELRVGISAKAAHKDFVQTWDGAGLKQIDHRARWPGESAIGERRLGGILGVLVGKIYDIRKRGSSRGTQAAEADNQTPTLSNPLSLPVTSAQQAAAAMLTKVQSLTKGVRPNKSSSGGRKRLEGKLKLQTLELERVPLSMQVCGRAIDWTVLTTLTLLDCAQHENLWKMLRRQFQPTPMSSGFGISSSSKPLPPNAPLQYHLALKYIHTDTTTPALISFLKETLAPNALEVLFLQDRRRVSSGPPVPLDAIFKGALKRHRSSLRKLLLDSSAKLPSSGTTTTADNTRWRNWMLSSDVVQYITSGRMINLRELAVSLDYKDWHTFLQRLPNVPELRSINIPHINDYVANAFDPRELAHQIADIITLRPEIHLSYVGIGSKCFEILETRDNGPSTGTTLAGSVESVPDAGGVLNPHLPNGGPSNGFVGDLDSDLEEEDTSEEEDVDEDGLVVDTTSDDDDDDDDDDDDNDNTPTTATSDPDETQSDNEEATVEEDDEDEDDSFVEPDQGGVKLRLREILFYDDKVAIFKARHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6P6</accession>
    <name>A0AAE0P6P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_460460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6P6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="255" mass="28150" checksum="27357BF08615AE7B" modified="2024-05-29" version="1">MSSMPASHGHSEACCNIPPVVSTGYNAKGSYEDLDGLKTYVTGPADATKGIIVIYDIFGFFEQTLQGADILATSDHQKYKVFIPDWFKGEPCPIEWYPPNTDEKKKNLGAFFGKNPPPGVAAKVPDYVKAVEAKYPSIKSWGILGFCWGGKVVSLVTSGDSNPFSVGAVAHPAMVDPTEAEKVRIPFILLASGEEPEDKVKEYEDNLKGSKHVEIFKDQIHGWMAARADLSKDRVKEEYTRGYKTVLEFFSKNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6R1</accession>
    <name>A0AAE0P6R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B0H63DRAFT_43414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6R1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041769741" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="48"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK3394349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="647" mass="68939" checksum="42353B38349423AC" modified="2024-05-29" version="1">MHLLALLPVTLLQAPLVLAEPVNSSPFYNERRAIANSPSGNYAPAIVNCPAVKPSVRVAGSLASEETAWLQLRRKATLDPMIAFLKRVNIAGFDAESYVKKDQPNIALAVSGGGYRALMNGAGFLAAADSRTTGNTDQGISGLLQASTYLAGLSGGGWLVTSIFANNFSSVETLRNGRDGSSLWQFANSIFVGPKQKGISILNTASYWTDVAGQVERKDDAGFQTSLTDYWGRALSYQLIDAPDGGPAYTFSSIAQDDLFSKAQTPLPILVADGRAPNTKIVSLNATVYEFNPFEMGSWDPSIFGFVPTKYLASNFSGGVIPDGGRCVQGFDQAGYVAGTSSTLFNQFLLSNLSTVANVPEFVIKAITGLLKDLDEDNNDIAQYVPNPFLGWNNATNPSAHDIELDLVDGGEDLQNIPLHPLLQPIRKVDVIFAVDSSADTTFNWPNGTALRASYDRQFSSIANGTLFPPVPDASTFINLNLNSRPAFFGCDVKNFSLSGSQSAPPLVVYIPNAPYTAFSNVSTFDPSYTDAERNDIIRNGFDSATQGNGTLDAQWPTCVACAVLSRSLARTGTAVPSACADCFSRYCWNGTLDSVDKGPYKPTFKIRDGTTKAQSGASSSRMLSSILSFPLAVVAALLGGGLLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P6S1</accession>
    <name>A0AAE0P6S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">B0H63DRAFT_407532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P6S1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="653"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3394307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="827" mass="90013" checksum="0610019C876BAD2C" modified="2024-05-29" version="1">MAIPKAPAGDVGYNTAVESVRDEEYPMMKGSIYLDHAGTTPYSKSLMDRFAQDMTSNLFGNPHSFSASSQLSTSRIEDVRLRVLQFFNADPDDFDVVFVANATAGIKLVADAMRSLPDGFDYAYHQMSHTSLVGIREEARNSVCLDDGQVEDWLAGTGPFSAGDTAGRTTLFAYPGQSNMDGQRFPLRWAGQLRRNCGSGANRTYTLLDAAALVCSSPLDLSCVDTAPDFTALSFYKIFGFPDLGALLVRRGAEGVFASRRYFGGGTVDMVVCLKEQWHAPKTQFLHECLEDGTLPIHSIIALDAAMDIHGKLFGSMLNVAAHTSFLSKRLFTGLGALRHGNGEPVCTLYSLDPSSSTNGPVIAFNIRNSLGAWASLAEFEKLATLKGFHIRTGGVCNPGGIASALGLEPWEVKQNFTSGFRCGSENDIMAGKPTGVIRASLGAMSTISDVDSFVDFVGEFYRDESVPSGRPELAPQDENSQLCVRGIFVYPIKSCGGFEVPKDVDWEVKLEGLAWDREWCLVHQGSGQALSQKRHPQMALIRPSLDFERGRLRITYAGHIPRQLPREITVPLSMNPTVFQPLVSLHSRSSRVCGEEILAQTYAAPEVTEFFTGVLGVPCVLARFPPGGQGKSMRHSKAHLQKHQVPQPSIRPRVPGSFPVPPSPPDSDSERVERRILLSNESPILAISLASLNELNKEIEKIGGSQVSPAAFRANVVIGCPPSARGLPGTQHTPYAEDSWSRLCIGDVGLEFTMLGSCRRCHMVCINQETAEKSEEPFVTLSKTRRFDGKVFFGTHMCYAPSAHAAVTKEAQFPTIRVGDVAAPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P762</accession>
    <name>A0AAE0P762_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP10 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_461526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P762"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3394638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="360" mass="39368" checksum="B88B125A29E28DE4" modified="2024-05-29" version="1">MASRTGSKALTCFSCQWRSFSVSYRRLADKIPPPPTTPTPAPASSSSNGTPLPTTTPGAPAAETLSGTPKPSGPLANAPRSYGKALKDFAPTPLGRPIGMSTPPKAGENTGIETRTLKQRRDDFVDYKKHLVRREQLKSKISRPYFRDWRNMQFHKGKTFLSPPRLFKADLSLYFPNLHGRTLNKGPTTDTTPVLEGRASVVTIFSSRWAENQAKSFTSPEANPVLHEALSASGGRAQLVQINVEEDALKSWIQVLFNGSLRRTVGKDNWGRYFLVRKGISDEIKEHIGLLNSKVGYTYLVDYKCRIRWAGSGNSEPEEREGLVKGVQRILDEMAGKTAAVKNSAGDALPAAEAGGKKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P770</accession>
    <name>A0AAE0P770_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B0H63DRAFT_491882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P770"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF199">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK3394591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="518" mass="57899" checksum="361C6DFCA4C782A7" modified="2024-05-29" version="1">MDIFDHKTVCLASVAGVLGLFLAVYSFTCVVYNLFFHPLAQVPGPMLWRASRLLFIRSLLSGNLPIDSKKIHQKYGDIVRIAPDEVSFARHDMWRDIFVGQDGHQPLPKNPTFWKAPPGQPDNLAFTSDPAASTRMRSVAMPAFTERALARQEPIMQAYVSLLVEKLSERASAAKIANQKAVINVMDYFNWLAFDLVGQLALGEDFGCLKETELHQWVAILFSSMRAMALAAATRYYAGLESILMYLIPASVRKAQTDHYSTARDKIHRRMLAEDTKRDDFMTPMLGENNPNFKNMSLPEVESTMVILLLAGSETTATALCGTFNYLTHNPAELRKLEQEIRGVFKREEDMTLRALQNLPFLNAVVSEGLRMCTPVPTGLFRIVPKGSGGATVCGVFLPEGTHVLANFNVMSFSEKSFYRAGDFLPDRFLPDGARPAEFDNDSRYDQKPFGAGSRACPGKGFALAEMRLVLARVVWRFEVSTAPGKQVDWNELKTYILVEKVPIEIVIKERPEASSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P7H8</accession>
    <name>A0AAE0P7H8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B0H63DRAFT_407923</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3394707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0P7H8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK3394707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="396" mass="44751" checksum="94E48FC9239D2F6C" modified="2024-05-29" version="1">MAEKGLEDVPEGQIESNYDETVDSFDEMNLKSELLRGIYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKIDPAVKQCQALILAPTRELAQQIQKVVVAIGDFMNIECHACIGGTSVRDDMKALQDGPQVVVGTPGRVQDMIQRRFLKTDSMKMFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKDELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQAQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTAEDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0P832</accession>
    <name>A0AAE0P832_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B0H63DRAFT_63713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3395044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="388"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1361"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1869"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK3395044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1957" mass="222318" checksum="C8964215DF9D89FC" modified="2024-05-29" version="1">MDESLGAHPSVTAAFAASPAGAPAPFISSLISSLDTISRATSPGIYSEDPHEDDKKRYRPRTFSYFRQLPFDVEDDAQRDVALTGILKNLYTAIMAEDFSPGALHWTRELQGWLNLKFEMTRELRARLVQLYYHLALAPGLDPNSADRFARMVITLTRKKHYLKPGEDLTLDWRPLWKCMKALVFPSEAAAHQGSRMRTQKHLIKLCLHANSYFDPRARRDMLEELLPFFSTSVMTNAYIVVGAINVMIPTGAAPPTEPQSQPSDFVPTFFHLWSLMTRSKSFDVCFIDIFSRMARDYLHCTHIPFTEHGIFTREQSDLIFTAILRLTEIPVGQANSPYASLDYASGLGVFLEKDKKKHPVPYMIARWIAHSLSPLCLNQESSILTSLEGLMESIDTFFHPSNQGAWTSFLAQLTFFLTDIFVSRWNREQSGELDVPPERRITAELKKRFVLALKEVTFMGLFAKSSKVVNYYYSTLQGLTYLEPDLMLPGALQRFYPSLQGLVEVHRTTSSLCGLQMIANLMSKQKGFRCHITALLALALPGIDANDLGKTQYTLNFIQSVAYSIPFVPLVREHDGIHDTSLAMNWVQGEMERMEREGQDVKISYAEELTDEDEASILRSSTAGLGEFVLALLGKVFALLENLPDASHLRTGSPEDNVINTLPAALLPLFASLSPELFDMALDKLATFVSTHVVHQARDAMAWICNALCKVNPEKTLKVFIPMLIVNIRNEIDYNGAASDRSSGSEVLPRDRALVWHVSMLSMCVVHVGGEVLKYKSELFGIAEYMQEKCRGLPTIHISNYIHHLLLNLTLTYPIDNSLYEPHVIARGLDVQDWGATTAPADLSIKWHRPSKPEIVFAVELFESQIRDASERLTQLMSDEPPVSRKGKNKEWSDELSRSLTALRLVISGVSTLFDPNRVSGEPESFSNGNGTLQADGDTVMEEDDDPLAEVADDEELKRQFHYPAGYLLTPKDRIYTHIHDLREEVGVLLSRTHAFLNANQEDDVACFTSLYATYRTFITDVGIERSAHPLERLVRLYKADISPFKISGLRKIYPRPLLIKRADAYQLQRVKYNSAYRKKSELDKRLLLDLAESCTSSYADVRRVAQTAQDSSLKVLIGGRPLVIPVLMDTLRKALDKSDHDRIKGAMYTLLFTTLIKTVMRDWRFAPDLMRLYIETAGVDKQSIQSLGSASLYPLLDFGKAFERLIIFDRSIVNTIRPSEDCSAVIKRRHDFIKERRAKVEEKKAALGLELTQKAKTSHWKIANRCAIFALNLSLRFETLVNSEFVDLVVKGTNDPHPGLRSNYLSAFSAIFTIIDMRAIYSHDYKNYLTEKEVRINKLRISVPSDDPEVTDKFLAQFEDFDSVKYFVDSDHPGWLVWGKEITVHKANPDPFLAYDAVETAVREQIGAILTKDWFKTCFEYLKQEPRDAGSDRFRMQNLVLLMNVFDLMHYGKTAATFEDIIDLIKDIYGDGSDKHQHRATAEIIGSLLSGSIDDPKEYRDKVWAFAAPMLLKVIADDLTPDNLQYWMTCLHLIVDAKDPRRCKELMEALTAFRLDMNSNAAFKESSKVQLVEFIINDAGWHFRHEEPILEDFLRHIDHPYKSVRESIGRVIATIYRTRYHESFPNVTTLLEQNKAASSIGIRAYQPSEEFSDTIHDVFDRLEKWRHERTPGQQTPSSYTSGSKTVLVWLDSMLSSQECIQLVPFFPDPFIDQLLHMMDVKEDPELMRLAYHVYRHLPNIPFRYGEDDAFIAALIRIGKTASSWHQRLRALVNMQVVYFRRLFLTQPEQRQMLFDAVGDMLADPQLEVRDCASATLAGMIRCSPASIRKPIIHQLKDRFERQLKMNPMPKRKLPGTDTPVDVQKQVVRRHAAVLGLGALIEAFPYATPPPSWMPEVLAHLASHAASDPGVVGKATKTILAEFKKTRQDSWGVDQKYFTSDQLEDLEGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVE9</accession>
    <name>A0AAE0TVE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_194397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3380918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVE9"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041950744" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3380918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="127" mass="13616" checksum="EEFE34951266316A" modified="2024-05-29" version="1">MKVSITLPIFLLQLSSTALAASCSGCANNKQCRYPDDLKATARTLCQQACAGDGDYIFTVNGNEGGDTAQFHLQPHTCPSHCVSAMNDIFDQCIGGGCTSGTWELDGQWYWVWAKMQNGANGCEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVP4</accession>
    <name>A0AAE0TVP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_475028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVP4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19513" checksum="E65627EA952720A9" modified="2024-05-29" version="1">MYAASVWAVDIKKGTTTLFAKTPEMAQVHNFTNIGINGVRVFEEHLYWTNSDLKAVYRIPLDACGYPGASPSSELVANLTTTSPVFIDDFTISKDGTLWVTSSGPDNVIVAVRPDGRGGFLEPVVAAGGIDSTAVQGAVGAAFGRGRDDKDILYVTTNGGLWGAGLGLNHTATEPGKVAAVDTTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TVY3</accession>
    <name>A0AAE0TVY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_475964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TVY3"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3381532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28188" checksum="B10FB4327A70D288" modified="2024-05-29" version="1">MSDQFLAEQHTWTLAQNARRAEVNVEDSWVMLTRDGEIVPIPDEKILFTSRARVGLELSTPRELQVAEPFSVKSDSGVAYITNERVIYLPARPTETFKSFFAPVLSFSDTHVQSSWIGPWSWGGVVRPVSGGGIPMNIPRIEAKLIFRDGGHSDFQAKFEWLKERLHHAQELGIIPGQNVEPPPPYDPISPVRSGEPSSGAPGPAAGAGGVTGAAVDQRQPPQPAPDEPPPDYVEAQAQAISMQYEQRTREEAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW04</accession>
    <name>A0AAE0TW04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B0H63DRAFT_546246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW04"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="267"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK3381654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="710" mass="78714" checksum="C7C37E1CCABF5E27" modified="2024-05-29" version="1">MCSEPTEVWEWDSSTKLAPAAPGQSGPLEFSRALVFQLGGDSIKTPRHQSSDWFVARGVDSLATVLDRGLDANSESSENDLIDDPEKRRKEGWYIFTGSDTWADCNTPLHMAMLSNSMDAAALLLSRGADINIHNARGQTPLDSAVSRGRSEWVEFLLSRGADGDAPTVQSSVTSGDSRDPEDGKRPPRKPYGPAADYFSRRFRQSYNLMNGITEVSDDIEPGYRLPSGVHDGPSLDPPRLPTRVIYLGKEEGSPHLMDANDLCAPYCALAYCRGNTKALATTRASLSSHLREIPVDALPKTPKDAIYAARQLGFEYIWIDALSILQDDEEDWGRESEAMQDVYYNARLILCASDSDDCDGGLFRKRGPGLVTPVQLTVPLSATAWPGKSCMYALPAQSANLPKGISPVDQRAWILQEIFLCARILFLGQNMLRWECLSVTAFETDPDGMNASKPPEEMEQHRAYEASLPYAAWEETVSQYSTRAITKQSDRIPALIGLGRRMESILGDQFVAGVWKQTFCLRSMCWQATSPGLGVEHYPSWSWTSTTSPVCYSMLDTDKVGRGIVTWHASVLECEAQILDPSQSTVRGSIKIKSMTRQGIDEYMIGKVEKRWGYNNGTSCALPGFEYGNPMFLDRSDESSSSGCLCLIIASTRKESRFGSPEVVCLLVRPSDDDDETKEAWRRVDICAVKDTEDFWLGVERRDRIISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TW89</accession>
    <name>A0AAE0TW89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_511581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000005">
        <property type="protein sequence ID" value="KAK3381862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TW89"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3381862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="184" mass="20756" checksum="CD785772718474B4" modified="2024-05-29" version="1">MPSTLGYERARFACPYHTLDPSQECIQPGWENCDGAAGSLSHLKGHFLFKHTETWCCGRCSQTFPTPTKRYEHGLMGCVEMPRPSIIQYMSKAREEQLKAVKNTKSGSAGGDEEMWWRWFRLLLPKIANIDGVLLMESYSPARLCCCCCGCSPAIHDQRCQTRIVRGLLNAVVTLRLKPLKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TYY7</accession>
    <name>A0AAE0TYY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_522133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3384788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TYY7"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3384788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="104" mass="11531" checksum="39E018A94413B5E6" modified="2024-05-29" version="1">MAWGRQTKSQAPPSTLSAILPLLITFTVLGALAWVGFQIYLSVMKIQAQAKKQMGDKNVVFTKDGVRVGVHHVETEDYLDKTQSWVVKAWNLGSTSKGGEKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0TZF0</accession>
    <name>A0AAE0TZF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_472413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0TZF0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3385132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="273" mass="29265" checksum="71928579FE1E02A6" modified="2024-05-29" version="1">MTTINSKALTREDASLKERMAAITKPLVLITGANAGIGFAVMENLVNSRKYHVLLGARADHKATAAVAELQQTNPDASSNITPVIIDVTDDASIAGAAEFVSSRFGRLDVLINNAGITISADRPAANRRENLHAVFDTNVFGVASVIDTFLPLLRKSTYPDRRIVNVSTGLSKIAVAYELESDWGARKLPAPEYRSSKAALNMLTAVYAVTLREEGILVVVAAPGYTRTKMTAGEGWKTPAEGARSIVRAATGGDRDELFGTMVADELTECKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U016</accession>
    <name>A0AAE0U016_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">APC1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B0H63DRAFT_433830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000283">
        <property type="entry name" value="Anaphase-promoting complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000531">
        <property type="entry name" value="Negative regulator of mitosis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1992"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1993"/>
            <end position="2015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK3385988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="2071" mass="227623" checksum="0B8E3A3950241B42" modified="2024-05-29" version="1">MASITSLGVHQPTALRHAIEEGILPPNPPPSSYTWEITTDNQGNNEGNGKGEGEASCDYEDELLTTQNCVLWSRGGIFRKSYKFDLENDPVTQALLTYFPASADSPDIITEIGQPQKKSADQLPVLSRALVVFLKTQAHIFFLSGTSHVVHMPFEVESACAAPCGVIIQRKSRTNAAAAPVSLRLPKVPPNSFLSLPPASPTSTRNQRVTEFSIEGLGNPKPLPLRLSSTLENMWQTPMETSESHWPRLVCLIDPLLEIGLVVARPDKPRTAGGGPRTSVSNLFLDPAEEILHVQEIQIPYESEEQRGKLNIAVTVNRETSMYSVWRLSYLQNDDPFIGRQKKKAKPVRRRSSMGPGLASGAATPVHPSARDSFGAPLPGKKSRKSVRIEEKDKDKDKDKALDNALSSLDPDKGTDATRRQSRRVSSLLARADLSASQDRSAFAQYPEARETLHQSLRPGAGGRRVESHGSDRRRVSGGHGGASFSGSFNHNLNSLAEAPVDNLLEELRAGGDFEGFHTMGLDDHDFDGLTHEMLFTKIHSITMDNANVRYSLSNKPARTHSRVFVLVGPPTATDERGRAALLVGIQDPVDKRLQLLTLLVEIKDETPKKSSKKKSPLDPSTVNVTFRDLRRVQSVVDSCKVSDGSEETIMILSEDKSGGRGLSLQSPWGPLTTVSLPLLFFDNLNSLDYSGSHQVNKEVRGRRSVGVGVTGTEVDSICHPKSRGVLDLRDTDGKFHRIRIKLRPSSPQVQLVLKVCRSVLAPSHAERLLVGWWHVMRWLEDFTTIGLEHPPTDTEWSALVILLLGSFLALKHASDASLLKCAAGLLPAAATGNWEAMQLHEMPNSSVCPPWMHNKGWSWLLEEGVLDAPERPDAASPKSVSFMSIHISLTKKYMASSNGVSAFGSNGYLPTGLSKDENSRITAAWSIMHALHLLSQEQKLNILSPEDSSPSQADLKGVLCQLAKWLGWQRFAALYAMDTQAELDDTPDSAPLFNISLDEPSADSCVLTWIQEHLTTEHGTDFPTLSQIYTTATRDEHISRPRQNLWNALTPRTLMFSKFFDLLRTTSSPYEMVVAMHTCGFTPQILETLPEAILTPLQDVIFMCQPNPPPNWPKTLLSLVNRTDISTVLQSKKGGRTLGSEIHPPTHIARWDFKMLCRHLDDFHDHIEETNGSERQAVVRSLFREDRRLNEAQNLLSSVKPRVVQLDPKKEWTESEYMDRVKDLVATVATGTLAVPAGRGLLYYSLRYPLLTQKYHISGFNLTCLVKPNNNAVGVDKTLFTEEKINWAFFHQGVAGGLAISPHAKGIDTSWILYNKPGQDLSNRHAGFLLALGLNGHLKSVAKWVAFKYLTPKHTMTSIGLLLGLAASYIGTMDSLITRLLSVHVTRMLPRGAAELNLSKHTQTTGIMGIGLLYCNSQHRRMSEIMMSEIEYIDDGEEEDPLRDEGYRLAAGFALGFINLGKGNDLKGLRDMRLTEKLLTLATSTKRVELVHVLDRSAAGAAVAIALIFMKSEDHIVARKIDVPDTILQFDYVRPDVLLLRTMAKNIILWKEIDPSFEWIQNGLPIEYRTRSRLTSVTKLLSKDLPFFSILAGLCWALGLRFAGSANSQVRDLLIHYLDEFLRIVRIPAVNFDSEMARGNVRMCLDMVALSCATVMAGTGDLIVLRRLRALHGRDDPNTTYGSHLAAHLAIGALFLGCGTATFGTSNLAIAALIVSFYPLFPASVQDNRSHLQAFRHFWVLATDPRCLVAKDLVTNQPLNVPMLIHLKPGSPSAVAATVEAAGAAKRAQTAATAASAFKDSLPDATSASNGLEVTILRRQTPCLLPPLDDVRRVSTDASALGFWNLVIDLEGAPHLVDDFRKNQSVYLRRRPAHESPFPATLRALGTREGAGADLSGRDPMEWIFGLDALSDLTHSERALVLDRLGSGGGIGEGEGASTAVDAKLVLKSGMDGWSRDRLLGLKLLFEWADRRSSLIPQPAALAGGAVVPDETAARGKEEKGKAPASTKKSETGRKTKKVMVQTSSEEMAAAPARDDTDAVSEAEKKHGWWLKDSAIEELKGMAWFVGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U031</accession>
    <name>A0AAE0U031_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_560502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3386033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U031"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3386033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="91" mass="10061" checksum="47FA4AD41FA27FDB" modified="2024-05-29" version="1" fragment="single">IALTILAHASARLLEAAPTCLTSLLPPRLAQRLSPLLYLIAIPKFETCQTRRYSFSKLFVPEILVESWVKWTNESKIPGPAGAATRALKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U037</accession>
    <name>A0AAE0U037_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B0H63DRAFT_473393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000004">
        <property type="protein sequence ID" value="KAK3385674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U037"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK3385674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20752" checksum="D7969B58B2834125" modified="2024-05-29" version="1">MLKLSKAVQRDQACIKEAFRDLVHVDREWSQDRTALTAEFVWIFEYYMIAEDLAVAPALDYYEGNGGERHPNLCHNYDLVNQELKQLYDLDPTAESWEASARAIWAKLEPLIIEETVTDLEEMESSMSDFAEKQAKKYDDVKKLLQKPYGDQGRPDDRKLLAMLEMPRGDLMAAIGVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U1G0</accession>
    <name>A0AAE0U1G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_148566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000003">
        <property type="protein sequence ID" value="KAK3387085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U1G0"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3387085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="266" mass="29389" checksum="5E3C5A3C18670AB8" modified="2024-05-29" version="1">MAYISLSRRDINVLEKIKDPESDPSSAVQVDPTLPKDPNILDQELYAKISQQEREIILSIQELELQSARHSAKEMAGMGIVGGYRECVARLGRLIQDHPDYASARNNRAQALRRLYGDSMLVTDSPQPLQALLRAVDETERLETAQAALCDLDRAISLLTPKGPHSSLSPQTARTLSMVYTQRATLYLMTSKLMPSKSVSIGVGRREASWTKLDFEENASRDFAMGGKYGNEIAKGLAVATNPTAKLCGQMVQEAMKKEYGPDFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U3V2</accession>
    <name>A0AAE0U3V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_537985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U3V2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3389887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="23335" checksum="2DD718D820A6974B" modified="2024-05-29" version="1">MVTLPSIFSPLTDIISFGESIQPGGSSRHGNQKNLASGASISATTHIPKCISIRQQDVQPRYISRLCLPATLPLVTNPYKRPPLPSHRHLDGKHRQSSLHSPRPKPRGAGIYHAVSLVLSILWSLPISGFRFLINANTLSVRSSPRSQPTPPISHLSFDAIQSALHRRRQQFPRPRPPALLVSTVPLPLGIMGMQSVLRRPCSSSCRHHPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U444</accession>
    <name>A0AAE0U444_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_105439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3389905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U444"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3389905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="453" mass="50597" checksum="E3CA07E03B78C007" modified="2024-05-29" version="1">MPTRNPTPEKDLTRKRKAHTKSRGGCVNCKIRHIKCDEIKPCCRRCYIFGVACSYDRASAHLQPLPAIAFTNTIPSPNTTLSANTQVLGLLNDSVSRQSAKEMAFRFSLHDLEIVNRFHARTILTVGNEKAAGIYQRESVRLAFQHPFLCHLVITLTLMHDRFNISEKQTTAELFHWLEGTSQFNSIISGASRGNLTSSQKDAVWIASIVLGCTTLAQVDSNNPEEIWPMQSTPSDLDWLKISTGKSEIWRLVNLGRSDSALRELCTDFAGGQPLPTATDSESLKVLPPELIELLELGSPTASPATNPYYGSAVVLARLLPLATTADNLIHFLQFIIQMTPRFMLLLEDKDPRALLLLVYYHAKISQDGRWWWRKRAMLEGQSICIFLERYHGNTSHLEMLLEFPKAHFWKGGNGYYGWDPPRSSLPWSSSLAALGEGAMVAGEQATVVQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U474</accession>
    <name>A0AAE0U474_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prp 4 CRoW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U474"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042047350" description="Prp 4 CRoW domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="24142" checksum="325B577814CBC562" modified="2024-05-29" version="1">MLAKSITALAALAFALHAAAEPMPYKPQVMKMSVRQLFGVVRREDVPGYQPEQAVCGTGATCADACGAGFTTCESGDSQVHCFNPAAAQTCCPDNTGNSCDAGYFCAADTVGETWCCPNGMSLTACAAAYSVSGGLVSETAKPTTSSTRVSSVVSTSAPVTTTSSVISFDKNSTTTAFSSGTAAGTGGLVPTASVTGSNITSTVRSIISSPTPTQSKVADNAGSVLAPAGALILLAAGIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4C6</accession>
    <name>A0AAE0U4C6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_111799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4C6"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF6">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G10320)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129407" checksum="17E18B656F3A2B94" modified="2024-05-29" version="1">MTMFKVKALYEYTSPHEDDLAFQAGQIITVTEEEDAEWYAGEYVDDAGTKHEGIFPRNFVEKYEPTAPPRPVRTRTARNTQDTAGASEASSASAPALPPPSPAVPAPEPEEKPEPVRIPEPTLTVSSPPAAPAPAPEPPAPKPAPPVQASVPPPPAPQPAEGPAARSAPPPKPAAPTLPKVSAGPPPPVSEKPAGASSFRDRIAAFNKPAAPPVAPFKPGGFGSGSAAFVKKPFVAPPPARNAYVPPPQQAPTAKVYRRDEDPEVKEQEAEALENAGKAGLVPAVPGAAEGEGEEDQPKPLSLKERLALLQKQQLETAARHADAVAKKEKPKRPPKKRMDSYEPSASATATDEHEPAAAPPPPPPERRDTRDTEEAPPKRSMDESHPPRIPHPPRRKSSKGIEPRDGNEADMSGAGETTEDQEELTEKEDADERPKHIALAAKQDDEEFGEEEEVDEEDEDDDVDPEVRRKEELRARMAKMSGGMGMPGMPGIPLFGGPPPMPKKKKTTDSRQSAEPEEPSSPTMRAPPIPPMMALPGMSRQTHEPEQADSNNDDEDEEEEARLRTPHQETAPSLPSREPGAAPPLPTGRPTLPPVPADSRPPPPPPPASAIKSASEGSVSDDELSERPYDESDRPRGEVAQATRAPPPPPPMLASPPPPLPPTSPRGVPRRQSYMDGASPTSPTIPAAPAPNRRNSRQPPPVPSSAPAPPPPSQTRPPPPPPTAAPPLRSHEDDDDAEEEITEYEGDYDTDIASSVPHKDALKSHQRESSFEDAVSPRSPIVEAPPIPSGIAPRAGPPPIPSQPPPPPNTRKSTDMPRVAPPPPPPPPPKETPRYDDDYDPYSYIAPVPVTSSPAIPAVPSFPMPTPPPHLRQSEDSFFNETPSYSAPHNPRAPPPAPPAGRGPTGAARQSLDVQRPGGGRRSMDVARPSMDSHFVANDIDLAGQSGWWLQPNSLPPQLQGRKDIFFESEESSAANTRRGGKTIVTRDIYVLFQDYSQTVITVRFDPQDASDVQLEQRHEAPPRALRQDQLEQSYERFGRAIGEAVVTKKDTVVGDGTPQGLIYELLRPLKDALLPVGTRAYGALVYSNLANASTTQNDEIRPGDIISIRNAKFQGKHGAMHAKYSMEVGKPDHVAVVGEWDGTKKKVRAWEQGRESKKVKLESFKLDDLRSGEVKIWRVMPRSWIGWEGQGNSSGGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4G0</accession>
    <name>A0AAE0U4G0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B0H63DRAFT_557158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK3390144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1412" mass="160612" checksum="80234FB959C3B226" modified="2024-05-29" version="1">MRPVRSGLWLSHRHSRKLTDDLRGIFARARTSILLHKVATSPPHSTDNMDHNSIETITTRLQHALALVEAHILPGGFAAAETVFQLAREEWQATLDPEHEAIFDIAYLQGFFYERNDHASRAEEVWRALLDECDRLGGRFSKRSIKIATQLGHFFAKRDRVTEYEDMYRRVVQAHKKLRTRSKEAFLDMARLADALQRQQRYGEAEDLWHEAIQGCQGLVGMDNGTMVCDFTNALVWIVFAHFRQLLSGNTPRDSHARLQCVTKAARLVRDLRDSQPSLGRAHTMQMLNMLGKMCLALGDEKNACVVFRFTRLQTILFDHADSPIFPICDVCEKLIHAKPCYVCKTCPDIDVCWDCYHAPCNQRSRTFRGLAECESHSFLEVAHQDTGAFDSPTAENLQEAALDCWLSNFIRLKQSDEDNFLDEFIPEPKVAWKVIRPAAQELECFEESMLQGSREEPVRDPRSLLWRRIFEIQIALPATTQQLFANEGFTLRSLPERQLSGRSTLDQIYEGVADVAGAFIRLAVRHQPHHSSPSDLSAHLGRSDTDSAQQNPIYLKKPLSLTKPMIRLLEILPGTSPQIRTSLFCIDFSQDRAYEALSYVWGLQALSSPAATTLVDVDGISVGVTPNLYSALLTLRHNNTSRLLWVDAICINQADNAEKATQVSMMSDIFMRADRVLVFLGDARPGSDLLFRYFNRDTRQDITLADWANRLETTSESLLREFVDFCDRGWWSRVWIQQEYAVAPQDPIFYLGRHSAEGAKIFSNVKALFDEFLNPEYFASHRAPLSATTNSQSPEDVMSSFTNRVMQVMEVLSRRGIESGRIHTREQASYLLQVDGALCTDPRDIVYGRLSFLEPTMRHIFVPDYSLPVIVVFEKLAAWTLIFDAWLDMFWYYPRKMPSCPSWVPDFTSRQRWLIGDSRPQPRTDMKGENGAITAWPAIYDRILAIHARPIDTVREVFVIDEPEWLSRASNLWHLDSYFATLADKTPSGSFSIRKALPRTFLDSGILQWASFMAQQDDDFGYRWTISASLESFPLMEYKVIIQNVFRPACSELFQMMQALRSETGAGTRSREEVFREAKLESEAAAAPEYMETYDRAVAYTVLAGVYCRLVWLQLKLDDLPWLTCGDLMGGSLFDLQNLRHRLRQVRIPQLGHDPGGSGSGLTMAESNIRSLLETLTTTKPINSDGARAKYPPVQSISDLHRPLYDDLQLVITDCRYQQEVLLRVELILQAAHAIHERLTPGNTTPRGQTTYLPAGETINLRDGQVKQLEEMYEAVAVMGDIGDVQNACFELWTKLTEGEIPQHAENEIRNERGKLVADTQTFSGLAHLYRQRTFFVTNNSFVGVGAPGVMDITVGDMVIMPENSNMPLLARPGGDCHELVGFASVRGLCDGRFHKLKEYQKPERKIFRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4I4</accession>
    <name>A0AAE0U4I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_519893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3390681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4I4"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041952340" description="Secreted protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3390681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="24826" checksum="86F5844629F22324" modified="2024-05-29" version="1">MLSSSSGRTTQPRHADSGWWKFASSLFLLTTTLTPLVASLPQGGGGQSPPAPTVQNMTMWGTGCPIGAGGLVQQMRNNTPVFVFSEWGLSLPDPETTSTSVSKFCTEAISLANGPVGMQLRIATVSVSGWAALDQGTKLAFHVETKLGDVLGGSQTAAISAGDLHANGFDVNLQTQPADLWSACVGADGIVPHILIQTTVSLVGTKLADGKLSGGVLGGDKSNLKKALGLHFDPVWRPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U4X8</accession>
    <name>A0AAE0U4X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_508391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000002">
        <property type="protein sequence ID" value="KAK3391208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U4X8"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3391208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="193" mass="21548" checksum="C4F87F7BC51BAB7D" modified="2024-05-29" version="1">MAYPVATGLPSQDAYGQYLPYATLAGEMTNPYQQYEAGYAQSVAAPITSKSQTYSFVMENLGKTPPRPRRRPDEIDRKYLCGWNGCEKAYGTLNHLNGHVTAQDHGQKRTSQEFSKVREERKARKKEKEAIRKANEERSGPDPNCSPLSSYSQLGQQMHYRLVGAGPASGGAPFTYEHPHLSRYTPERGSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6G2</accession>
    <name>A0AAE0U6G2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3392706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6G2"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042097150" evidence="2">
        <location>
            <begin position="20"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK3392706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="985" mass="103603" checksum="1F728213596498CC" modified="2024-05-29" version="1">MHLTRAALAIALAATTTSALPKCGDVYGSIDEKRSLCGSGFTVRPDQKRSYAPGAASIKNDEPANGGLATPPNSPSHSADEKRDEVRHQPPYEAPVAHFKSGSSGETVEMQPIDSKIGMSSGSSGWKSRSGKRSHHLNVQGWSNGGQGVTEDGLHRIGARGDDDEDDDDEGDTIIMNEEQQHHTGARLYQAAGNRVQARGHYLTEIEDAQRTAGAVAPGKVQAFDKPITLVFPAEDFQRVGGVAPTKAIQARGEGQPAVTIVIPDDDAQRTAGARVYFPNPNNGVPAFLGPKSSPFKAIRDFVKSTLGGQLEGEQSLHAMSMNHGGMSSSSSSSSPDKKYYQGSSKRSTEYAQPYAGLVPPAKKFDTSLPPLFGVDKVKSESNEEEERFSNSGISQPPAQQPVQVRSTSERYTGSGGVETSMEEEMGNLKINARQDVQPASANGMRFSGKPYSCSGQGCLPLSSEEDSHDNQNQPSQHVFRRTEGGVEVQDEENKENPARLKMAKGSNSGVSASGGAINYRSTEGSVEVQDEEIKENPARLKMVKGSNSGVSANGGAINYRSTEGSVEVQDEEIKENPARLKMVKGSNSGVSANGGAINYRSTEGGVEVQDEENKENPARLKMAKGSNSGVSASGGAINYRSTEGGVEVQDEEIKENPARLKMVKGSNSGVSANGGAINYRSTEGGFEVQDEENKENPARLKMVKGSNSGVSANGGAINYRSTEGGFEVQDEENKENPARLKMVTGIISGSNSAGISGSRTLLYRSTEGGVEVQDDENKENSAVLKMTKGGSKLGVVGSAPEVAGAGSGSGGSGGSGSTTSAEKYAIPAADVPQHVEPYNDFSSVGQSSSSWSGGVLQKNNDDSQGTIANSATGTDVHDWAYTKMAMSNSQSTMNGASSGNSNTAEERRRSLQQPPSQEGSMFHQLDGQSDGTVKCSNSNGFGCDGSTGARGRFDSFKPKGARSEPFTPPTGSYSSAGKVDQVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U6X1</accession>
    <name>A0AAE0U6X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B0H63DRAFT_505081</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U6X1"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041901462" description="chitinase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="18">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="17">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="585"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="924"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="620"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="710"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="806"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK3393112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="1163" mass="113948" checksum="C675D867C1C763AB" modified="2024-05-29" version="1">MYNYKKSLAVAVLAAVPALASPSVNVYWGQTGSQTLGEYCEQSNGFEIITVGFVNNSPEKDPSGLNYAGTNFAAHCSADVYQNGNQKSNLLSKCTIIAGDIPKCQALGKKVLLAIGGVFNNTGPIKSDYTVTTVENGNYFAEFVWNAFGPYNPAKSTPRPFDFDGKHVQFDGFDFDIEVKFFDPKGIVAMAKRLRELIDAAPGKYLLTAAPECPLDSANFKMDAIILEARFDALFIQYYNNVGCEATSGNFESNYVAWEQWISNTASKDAKLYVGLPGSSAAAGSGYLSADAAVTLLSKVKNRASFGGASVWDVEYAKEKVNGKTFYEAIHSGIGAVYPTPTASSTTTSPTAQPTACVKYVEVVPGDWCEKIATANGITVDELRALNPGKLNDACAIFPGEELCVKLGYASTSSTVSTTSVSGSASSIAASSTVSSTSSSAAASSSVAASSSAAASSNIAASSSVAASSSVAASSSAAASSSIAASSSVAASSSVAASSSAAASSSVAASSSAAASSNIAASSSVAASSSVAASSTPVVAASSSVAASSSVAASSSAAASSSVAASSSEVASSSIISSTTTDASSTITSAPVSSSPASSVTSTTTTATDDEDDCEDETESSTLASSTATDVSSSASSTASDVSSTASSTVSNVSTTVSSTASDVSSTASSTVSDASSTITSAPVSSASASSTTSSSTATDDDEECEDESSTLASSTAVDSSSAVLSTSASVTTSDVSSTASSTASEISSTPSSTASDISSTVSDVSSTITSAPVPSSAPASSATSTSTATDDDDDDDDTCDEETESSTLPVSTTSTESSSAASSAAPSSTVSASSTGSVTESASSSASLSASETTSSTASASETASSSASASETTSSTASASETASSSASASESVSSTASASEFVSASGSVSASSAASSNVVSSTASQSSAVSSTGPISSTITIGPSSTTPGEEISSTTSTIYSTTTYTVTACPATVTNCPLGHVVTKTIVIGTTVCPVTVTPTGTAAPSSSELPEGWTTSTVYATTTYTITSCAPTVTNCPAKLGQVTTEVIAVSTTVCPVGEGAPAASAPAFSAKATPSAEVPGASQSTTVVKPVANSPVSLSTVVNSAKPTPATPSTVSTGTLAVVAPTASGKLPVTAGAGRNAVALGVPVLAAALFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U763</accession>
    <name>A0AAE0U763_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_18446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U763"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042132814" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11395" checksum="083288C4B7D778F4" modified="2024-05-29" version="1">MFGFGAWLWLFPCLAERCEVNKKEKVGRRRSNDFGYTYVRQETFTKGAFVWFFPFSLSCLLDQARKAVKTDLKNLYDGLLFPVFTVPFWCMRLQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U766</accession>
    <name>A0AAE0U766_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B0H63DRAFT_516306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U766"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK3393100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="341" mass="36763" checksum="B86D882BB7CCD971" modified="2024-05-29" version="1">MGSSNRKKKEKKKDFQKAKLKVGKAAVKAANFTDTSFKSKSIVVNQQTLAGDGTDSVEQFKQTLASAVNAKTDNIRRDALSYLINQLSGKPPNNPVGTAGLLTRLLPLISDSATSVRANLLKLFRVLPPSQVKPHVEKILMYVRGGMAHLSTAVRNDTLDVLEWLLDVAGDETVSCPGGWLKTLNSLSSMLGWNPSVGSALSSQGWTSGSKTTLVGTKKGGEAGARQIHVLARLLQTGFQPESPIPYNPQAYWDNIYRLPATPNPFAYLNLFGSPRDEDNEMYPDRISRQRVFDAKWRSVIVAGMDGAKREGGLVGRAASALKKALNEGADAPITSPGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U797</accession>
    <name>A0AAE0U797_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B0H63DRAFT_458645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U797"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK3393621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="212" mass="23389" checksum="C405A4DC76968BB3" modified="2024-05-29" version="1">MAGFVLFETTESVIELLWDVALAFFIVRLGFIYFALNFASGLLLSTLAYYFPEQLTPLLAYAHLTMIPTTMTALSEFVLVGFVLAGFATLWARFLVVHYEIPRVAGFRLAIGATALVLASFAESIAALVLVEQGKGAWLWSKIIDLKTDAAFGGLLAVFTLMPWLQMGFEQGRSEGEVFRPEAAHGHEKKTLVDAIPTVNMSEKTQETKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U7D5</accession>
    <name>A0AAE0U7D5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic reticulum Oxidoreductin 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B0H63DRAFT_459040</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
            <dbReference type="PubMed" id="37820761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2023-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Lawrence Berkeley National Laboratory"/>
                <person name="Haridas S."/>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yanf M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Thoren M.H."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 232.78</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAULSW010000001">
        <property type="protein sequence ID" value="KAK3393741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAE0U7D5"/>
    <dbReference type="Proteomes" id="UP001285441">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042123849" evidence="20">
        <location>
            <begin position="20"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK3393741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001285441"/>
        </source>
    </evidence>
    <sequence length="629" mass="70984" checksum="37AC00E4988EE8A2" modified="2024-05-29" version="1">MLARYALAAILILNLATTATPVCVQPHDAPAAPAAATAVEFRFNFFSNRSSFQISLKAIVNDACASYSTLERLNRNVKPALDELVQTTDFFSHYRLNLFSKKCPFWDDENGMCGNIACAVETLDNEKDIPEVWRASELGKLEGPRAKHPGKSMQLEEPVKPLHGKLGENVGESCVVEYDDECDDRDYCVPEDERAGSKGDYVSLLRNPERFTGYAGDGARNVWDAVYRENCFQKSSFPHSASLGKVPTPKGPAAMDFKAVIEAAGRQQVLESERQHNPLTPFVAKTGLEHEDECLEKRVFYRVMSGMHASISTHLCWDFLNQTTGKWQPNVACYKSRLHQFPDRISNLYFNYALLTRAVAKLGPYLAQHEDYTFCTGDPGQDAATRAKVLAVTEEAASVPQIFDESLMFKNGEGPSLKEDFRNRFRNVSRLMDCVGCDKCRLWGKLQTAGYGAALKVLFEFDNNHQPEVPVLKRTELVALFNTYARLGSSLNAIQKFRTMLDDAEGPKTETKESVKVIPDWAKKPRHVIPSPKKPEEPATPEPSVLAGEDEPLEGPEEEERERTISDDFNEEFGRFTKAIKLVLRSWISFPGFLWQILTSEFKRFWQFYLGLPVSPRTWQFQRPSLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-05-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAE0U818</accession>
    <name>A0AAE0U818_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B0H63DRAFT_531806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Podospora didyma</name>
        <dbReference type="NCBI Taxonomy" id="330526"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Podosporaceae</taxon>
            <taxon>Podospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="0" last="0">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
        
[file cut: first 33554432 bytes kept]
[document cut: first 30786684 of 33549494 characters kept]
